subject:(Gadolinium)

Oregon State University

1. Hartley, Kenneth D. Gadolinium particle depletion in light water reactor fuel rods.

Degree: MS, Nuclear Engineering, 1988, Oregon State University

URL: http://hdl.handle.net/1957/39495

► Gadolinium is an important element to the Nuclear Fuel Industry. Two of the seven naturally occurring isotopes of gadolinium have very large absorption cross sections… (more)

Subjects/Keywords: Gadolinium

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APA (6^th Edition):

Hartley, K. D. (1988). Gadolinium particle depletion in light water reactor fuel rods. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/39495

Chicago Manual of Style (16^th Edition):

Hartley, Kenneth D. “Gadolinium particle depletion in light water reactor fuel rods.” 1988. Masters Thesis, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/39495.

MLA Handbook (7^th Edition):

Hartley, Kenneth D. “Gadolinium particle depletion in light water reactor fuel rods.” 1988. Web. 02 Mar 2021.

Vancouver:

Hartley KD. Gadolinium particle depletion in light water reactor fuel rods. [Internet] [Masters thesis]. Oregon State University; 1988. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/39495.

Council of Science Editors:

Hartley KD. Gadolinium particle depletion in light water reactor fuel rods. [Masters Thesis]. Oregon State University; 1988. Available from: http://hdl.handle.net/1957/39495

Oregon State University

2. Lee, Chungchan. A two-group study on the gadolinium particle depletion in light water reactor fuel rods.

Degree: PhD, Nuclear Engineering, 1989, Oregon State University

URL: http://hdl.handle.net/1957/39435

► The effect of gadolinia particles on the assembly criticality of a light water reactor was investigated using two 2-group models. The particle effect was calculated… (more)

Subjects/Keywords: Gadolinium

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APA (6^th Edition):

Lee, C. (1989). A two-group study on the gadolinium particle depletion in light water reactor fuel rods. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/39435

Chicago Manual of Style (16^th Edition):

Lee, Chungchan. “A two-group study on the gadolinium particle depletion in light water reactor fuel rods.” 1989. Doctoral Dissertation, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/39435.

MLA Handbook (7^th Edition):

Lee, Chungchan. “A two-group study on the gadolinium particle depletion in light water reactor fuel rods.” 1989. Web. 02 Mar 2021.

Vancouver:

Lee C. A two-group study on the gadolinium particle depletion in light water reactor fuel rods. [Internet] [Doctoral dissertation]. Oregon State University; 1989. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/39435.

Council of Science Editors:

Lee C. A two-group study on the gadolinium particle depletion in light water reactor fuel rods. [Doctoral Dissertation]. Oregon State University; 1989. Available from: http://hdl.handle.net/1957/39435

3. Dudeffant, Clémence. Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins.

Degree: Docteur es, Sciences de la vie et de la santé, 2018, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2018SACLS281

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L’imagerie par résonnance magnétique (IRM) est devenue un outil incontournable en recherche biomédicale. Le développement d’outils de neuroimagerie pour le petit animal est primordial pour… (more)

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L’imagerie par résonnance magnétique (IRM) est devenue un outil incontournable en recherche biomédicale. Le développement d’outils de neuroimagerie pour le petit animal est primordial pour valider des hypothèses biologiques et tester l’efficacité de nouvelles thérapies. Dans le contexte de la maladie d’Alzheimer (MA), l’utilisation d’IRM à haut champ magnétique permet l’imagerie des plaques amyloïdes, signature moléculaire de cette pathologie. Cependant, seule une faible proportion de ces lésions sont détectées et aucune méthode de neuroimagerie ne permet actuellement d’imager les dégénérescences neurofibrillaires, deuxième signature microscopique de la MA. Dans cette thèse, deux méthodes complémentaires, utilisant différents agents de contraste à base de Gadolinium (Gd), ont été étudiées pour améliorer la détection des plaques amyloïdes par IRM. La première partie de cette thèse s’est intéressée à la méthode du « Gd- staining ». Une étude comparative réalisée sur différents modèles murins d’amyloïdose et sur des primates non-humains, a permis de mieux comprendre les mécanismes impliqués dans la détection des plaques amyloïdes grâce à cette technique. Également, nous avons montré pour la première fois qu’il est possible d’imager les lésions Aβ humaines, en post mortem, par Gadolinium-staining. La deuxième partie de cette thèse s’est intéressée au développement d’agents de contraste vectorisés, ciblant spécifiquement les lésions de la MA. Ces molécules seraient capables de traverser spontanément la barrière hémato-encéphalique, principale limite au développement de molécules à visée cérébrale, et permettraient de cibler spécifiquement les deux lésions caractéristiques de la MA. Ces propriétés font de ces molécules de outils potentiels intéressants pour l’imagerie cérébrale de la MA.

Magnetic resonance imaging (MRI) has become a key tool for both clinical and preclinical research. Developing innovative neuroimaging techniques specifically designed for small animal models is therefore crucial to validate biological hypotheses and screen new drugs. Amyloid plaques and neurofibrillary tangles are the major lesions characterizing Alzheimer’s disease (AD) and intensive research has been carried out in order to enable the accurate detection of amyloid plaques using high-field MRI. However, only a small portion of plaques are spontaneously detected by MRI and no method is so far available for neurofibrillary tangles imaging. Here, we develop two contrast-enhanced MRI techniques to improve amyloid plaques detection using high-field MRI. The first part of this work focuses on Gadolinium-Staining for amyloid plaques detection by MRI. We performed a comparative study between mice model of amyloi-dosis and non-human primate models, which al-lowed us to gain a better understanding of the origin of the contrast induced by amyloid plaques when performing contrast-enhanced MRI. We also showed for the first time that Gd-stained MRI is able to detect amyloid plaques in human-AD brain tis-sues. The second part of this manuscript…

Advisors/Committee Members: Dhenain, Marc (thesis director).

Subjects/Keywords: Alzheimer; Gadolinium; Microscopie par IRM.; Nanocorps; Vhh; Gadolinium staining; Alzheimer; Gadolinium; Magnetic resonance microscopy; Nanobodies; Vhh; Gadolinium staining

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dudeffant, C. (2018). Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2018SACLS281

Chicago Manual of Style (16^th Edition):

Dudeffant, Clémence. “Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins.” 2018. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 02, 2021. http://www.theses.fr/2018SACLS281.

MLA Handbook (7^th Edition):

Dudeffant, Clémence. “Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins.” 2018. Web. 02 Mar 2021.

Vancouver:

Dudeffant C. Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2018. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2018SACLS281.

Council of Science Editors:

Dudeffant C. Développement et évaluation d'agents de contraste pour détecter la maladie d'Alzheimer par IRM : coloration par le Gadolinium et nanocorps ciblant les protéines Aβ et Tau : Development and Evaluation of Contrast Agents to Detect Alzheimer's Disease by MRI : Gadolinium Staining and Nanobodies Targeting Amyloid β and Tau Proteins. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2018. Available from: http://www.theses.fr/2018SACLS281

Delft University of Technology

4. Garretsen, Astrid (author). Next-generation neutron capture therapy.

Degree: 2018, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b

► Neutron capture therapy (NCT) is a binary form of radiotherapy that utilizes the high cross section of some nonradioactive elements, in particular boron-10 and gadolinium-157,… (more)

Subjects/Keywords: Neutron capture therapy; Boron; gadolinium

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APA (6^th Edition):

Garretsen, A. (. (2018). Next-generation neutron capture therapy. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b

Chicago Manual of Style (16^th Edition):

Garretsen, Astrid (author). “Next-generation neutron capture therapy.” 2018. Masters Thesis, Delft University of Technology. Accessed March 02, 2021. http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b.

MLA Handbook (7^th Edition):

Garretsen, Astrid (author). “Next-generation neutron capture therapy.” 2018. Web. 02 Mar 2021.

Vancouver:

Garretsen A(. Next-generation neutron capture therapy. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Mar 02]. Available from: http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b.

Council of Science Editors:

Garretsen A(. Next-generation neutron capture therapy. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:810ffad9-5f6b-4e52-a0c6-7f4795e3fa7b

University of Sydney

5. Kardashinsky, Mingyue Tang. Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies .

Degree: 2017, University of Sydney

URL: http://hdl.handle.net/2123/17161

► Gadolinium photon activation therapy (GdPAT) is a binary cancer treatment for glioblastoma multiforme. It relies on the release of high linear energy transfer (LET) particles… (more)

Subjects/Keywords: Phosphonium; Gadolinium; Binary; Photon Activation

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APA (6^th Edition):

Kardashinsky, M. T. (2017). Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/17161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kardashinsky, Mingyue Tang. “Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies .” 2017. Thesis, University of Sydney. Accessed March 02, 2021. http://hdl.handle.net/2123/17161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kardashinsky, Mingyue Tang. “Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies .” 2017. Web. 02 Mar 2021.

Vancouver:

Kardashinsky MT. Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies . [Internet] [Thesis]. University of Sydney; 2017. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2123/17161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kardashinsky MT. Functionalised Phosphonium Salts for Gadolinium Binary Cancer Therapies . [Thesis]. University of Sydney; 2017. Available from: http://hdl.handle.net/2123/17161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

6. Hall, Andrew. Gadolinium(III) Complexes as Potential Theranostics .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/19753

► Neutron capture therapy and photon activation therapy are binary cancer treatments based on the release of high linear energy transfer particles from specific nuclides following… (more)

Subjects/Keywords: gadolinium; phosphonium; theranostic; mitochondria; glioblastoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hall, A. (2018). Gadolinium(III) Complexes as Potential Theranostics . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/19753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hall, Andrew. “Gadolinium(III) Complexes as Potential Theranostics .” 2018. Thesis, University of Sydney. Accessed March 02, 2021. http://hdl.handle.net/2123/19753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hall, Andrew. “Gadolinium(III) Complexes as Potential Theranostics .” 2018. Web. 02 Mar 2021.

Vancouver:

Hall A. Gadolinium(III) Complexes as Potential Theranostics . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2123/19753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hall A. Gadolinium(III) Complexes as Potential Theranostics . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/19753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

7. Ng, Leung-Kai. Re-investigation of the excited states of Gd 154.

Degree: PhD, Physics, 1967, University of British Columbia

URL: http://hdl.handle.net/2429/36849

► The excited states of Gd 154 obtained from the decay of Eu 154 have been investigated. Precise measurements of the energies and intensities of the… (more)

Subjects/Keywords: Gadolinium earths

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APA (6^th Edition):

Ng, L. (1967). Re-investigation of the excited states of Gd 154. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/36849

Chicago Manual of Style (16^th Edition):

Ng, Leung-Kai. “Re-investigation of the excited states of Gd 154.” 1967. Doctoral Dissertation, University of British Columbia. Accessed March 02, 2021. http://hdl.handle.net/2429/36849.

MLA Handbook (7^th Edition):

Ng, Leung-Kai. “Re-investigation of the excited states of Gd 154.” 1967. Web. 02 Mar 2021.

Vancouver:

Ng L. Re-investigation of the excited states of Gd 154. [Internet] [Doctoral dissertation]. University of British Columbia; 1967. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2429/36849.

Council of Science Editors:

Ng L. Re-investigation of the excited states of Gd 154. [Doctoral Dissertation]. University of British Columbia; 1967. Available from: http://hdl.handle.net/2429/36849

The Ohio State University

8. Schehl, Richard Rayner. Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals.

Degree: PhD, Graduate School, 1969, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu148665534455133

Subjects/Keywords: Physics; Gadolinium

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APA (6^th Edition):

Schehl, R. R. (1969). Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu148665534455133

Chicago Manual of Style (16^th Edition):

Schehl, Richard Rayner. “Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals.” 1969. Doctoral Dissertation, The Ohio State University. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu148665534455133.

MLA Handbook (7^th Edition):

Schehl, Richard Rayner. “Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals.” 1969. Web. 02 Mar 2021.

Vancouver:

Schehl RR. Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals. [Internet] [Doctoral dissertation]. The Ohio State University; 1969. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu148665534455133.

Council of Science Editors:

Schehl RR. Electron paramagnetic resonance of gadolinium (III) in cadmium sulfide single crystals. [Doctoral Dissertation]. The Ohio State University; 1969. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu148665534455133

Université de Grenoble

9. Tallec, Gaylord. Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents.

Degree: Docteur es, Chimie, 2011, Université de Grenoble

URL: http://www.theses.fr/2011GRENV051

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L'imagerie par résonance magnétique est une des méthodes de diagnostic les plus utilisées, aussi bien dans le domaine médical que dans les études précliniques. Cependant,… (more)

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L'imagerie par résonance magnétique est une des méthodes de diagnostic les plus utilisées, aussi bien dans le domaine médical que dans les études précliniques. Cependant, la relaxivité des agents de contraste commerciaux ne représente qu'une fraction de la relaxivité prédite par la théorie et il est nécessaire d'optimiser les différents paramètres dont elle dépend pour atteindre des valeurs de relaxivité plus élevées : nombre de molécules d'eau en première sphère de coordination, vitesse d'échange de l'eau, dynamique de rotation du complexe, relaxation électronique, distance Gd(III)-proton. Dans ce travail, nous présentons la synthèse, la stabilité et la relaxivité des complexes de Gd(III) de deux séries de ligands tripodes dérivés de la 8-hydroxyquinoléine, basés l'une sur une plateforme 1,4,7 triazacyclononane, l'autre sur un pivot azote central. Ces complexes ont montré des stabilités comparables à celles des agents commerciaux, des valeurs de relaxivités élevées dans l'eau ainsi qu'en milieu biologique. L'utilisation de la 8-hydroxyquinoléine comme base des ligands a permis de sensibiliser le Nd(III) et l'Yb(III) pour la luminescence proche infrarouge, ouvrant la possibilité pour le développement de nouveaux systèmes bimodaux.

Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice as well as in biological and preclinical research. However, the relaxivity of commercial contrast agents is only a few percent of the theoretically predicted relaxivity. An optimisation of the different parameters who have an impact on the relaxivity (number of gadolinium bound water molecules, water exchange rate, rotation dynamic of the complex, electronic relaxation, Gd(III)-proton distance) is needed to obtain higher relaxivities. In this work, we present the synthesis, the stability and the relaxivity of the Gd(III) complexes of two series of 8-hydroxyquinolinate-based ligands, one using a 1,4,7 triazacyclononane platform, the other one using a central nitrogen architecture. Theses complexes show stabilities comparable to commercial agents, and high relaxivities in both water and serum. The 8-hydroxyquinolinate moiety allows these ligands to sensitize Nd(III) and Yb(III) for Near Infra Red (NIR) luminescence, leading to a new class of potential bimodal systems.

Advisors/Committee Members: Mazzanti, Marinella (thesis director).

Subjects/Keywords: Gadolinium; Agent de contrast; IRM; Luminescence; Gadolinium; Contrast agent; MRI; Luminescence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tallec, G. (2011). Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2011GRENV051

Chicago Manual of Style (16^th Edition):

Tallec, Gaylord. “Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents.” 2011. Doctoral Dissertation, Université de Grenoble. Accessed March 02, 2021. http://www.theses.fr/2011GRENV051.

MLA Handbook (7^th Edition):

Tallec, Gaylord. “Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents.” 2011. Web. 02 Mar 2021.

Vancouver:

Tallec G. Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents. [Internet] [Doctoral dissertation]. Université de Grenoble; 2011. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2011GRENV051.

Council of Science Editors:

Tallec G. Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence : New lanthanides complexes for the development of bimodal MRI/NIR luminescence contrast agents. [Doctoral Dissertation]. Université de Grenoble; 2011. Available from: http://www.theses.fr/2011GRENV051

10. Courant, Thomas. Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging.

Degree: Docteur es, Chimie, 2011, Reims

URL: http://www.theses.fr/2011REIMS005

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L’objectif poursuivi au cours de ce travail est l’encapsulation de complexes métalliques au sein de nanoparticules biocompatibles, et ce pour des visées diagnostiques. Dans ce… (more)

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L’objectif poursuivi au cours de ce travail est l’encapsulation de complexes métalliques au sein de nanoparticules biocompatibles, et ce pour des visées diagnostiques. Dans ce but, un protocole de double émulsion-diffusion de solvant Wi/O/We, n’utilisant que des composés biocompatibles, a été mis au point et optimisé pour obtenir, de façon quantitative et reproductible, des nanoparticules de PLGA de diamètre compatible avec une injection par voie parentérale. Cette formulation a été employée avec succès pour l’encapsulation de complexes modèles de Cu(II). Les formulations optimales permettent d’obtenir des nanoparticules possédant des diamètres hydrodynamiques moyens inférieurs à 200 nm avec des efficacités d’encapsulation entre 20 et 25 %. L’utilisation de cette formulation pour l’encapsulation de chélates de gadolinium ne permet pas d’obtenir des rendements d’encapsulation satisfaisants. La modification du protocole vers une méthodologie Wi/O1/O2ne permet pas d’améliorer l’encapsulation et dénote l’absence d’affinités entre le polymère hydrophobe et les complexes hydrophiles. L’utilisation de nanoparticules composées d’une matrice hydrophile permet d’obtenir des taux de charges nettement supérieurs. Ceci conforte l’hypothèse selon laquelle les interactions entre le complexe et la matrice des nanoparticules jouent un rôle crucial pour l’encapsulation.

The goal of this work was to encapsulate metal complexes into biocompatible nanoparticles for diagnostics. To reach this purpose, a double emulsion-solvent diffusion Wi/O/We technique was optimized, using only biocompatible compounds. It allowed the obtention of PLGA nanoparticles that are compatible with parenteral injections in a reproducible and quantitative way. This formulation was successfully applied to encapsulate model Cu(II)complexes. Optimal formulations showed mean diameters below 200 nm with encapsulation yields in the 20-25 % range. The use of this formulation for gadolinium chelates did not lead to satisfactory encapsulation yields. Thereafter, a Wi/O1/O2 methodology was developed but could not allow to raise the encapsulation efficiencies. This point showed the lack of affinity between the hydrophobic polymer and the hydrophilic chelates. The use of nanoparticles made of an hydrophilic matrix showed a ten-fold increase in the drug loading efficiency. This confirms the hypothesis in which interactions between chelates and nanoparticle matrices play a crucial role for encapsulation.

Advisors/Committee Members: Chuburu, Françoise (thesis director), Andry, Marie-Christine (thesis director).

Subjects/Keywords: Encapsulation; Gadolinium; Agents de contraste.; PLGA; Encapsulation; Gadolinium; Contrast agents.; PLGA

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APA (6^th Edition):

Courant, T. (2011). Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging. (Doctoral Dissertation). Reims. Retrieved from http://www.theses.fr/2011REIMS005

Chicago Manual of Style (16^th Edition):

Courant, Thomas. “Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging.” 2011. Doctoral Dissertation, Reims. Accessed March 02, 2021. http://www.theses.fr/2011REIMS005.

MLA Handbook (7^th Edition):

Courant, Thomas. “Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging.” 2011. Web. 02 Mar 2021.

Vancouver:

Courant T. Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging. [Internet] [Doctoral dissertation]. Reims; 2011. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2011REIMS005.

Council of Science Editors:

Courant T. Nanoparticules incorporant des complexes inorganiques à visée diagnostique : Metal complexes-loaded nanoparticles for diagnostic and medical imaging. [Doctoral Dissertation]. Reims; 2011. Available from: http://www.theses.fr/2011REIMS005

11. Beena, S. Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions.

Degree: Applied Chemistry, 2010, Cochin University of Science and Technology

URL: http://dyuthi.cusat.ac.in/purl/2678

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In many fields such as earth science biology, environment and electronics, the knowledge about elemental distributions and chemical speciation is important. The determination of metal… (more)

Subjects/Keywords: Lanthanum; Samarium; Praseodymium; Neodymium; Gadolinium; Potentiometric Sensors

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APA (6^th Edition):

Beena, S. (2010). Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/2678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Beena, S. “Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions.” 2010. Thesis, Cochin University of Science and Technology. Accessed March 02, 2021. http://dyuthi.cusat.ac.in/purl/2678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Beena, S. “Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions.” 2010. Web. 02 Mar 2021.

Vancouver:

Beena S. Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions. [Internet] [Thesis]. Cochin University of Science and Technology; 2010. [cited 2021 Mar 02]. Available from: http://dyuthi.cusat.ac.in/purl/2678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beena S. Fabrication of Potentiometric Sensors for the Determination of Lanthanide Ions. [Thesis]. Cochin University of Science and Technology; 2010. Available from: http://dyuthi.cusat.ac.in/purl/2678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

12. Darrah, Thomas Henry (1981 - ). Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance.

Degree: PhD, 2011, University of Rochester

URL: http://hdl.handle.net/1802/14539

► Research presented in this thesis investigates the trace element, rare earth element, and lead isotope chemistry of cortical and trabecular bone tissues of modern humans.… (more)

▼ Research presented in this thesis investigates the trace element, rare earth element, and lead isotope chemistry of cortical and trabecular bone tissues of modern humans. Samples are of femoral heads discarded following full hip replacement surgeries at the URMC. Chapter 3: Quantification of the existing NIST certified standard reference material for analysis of human bones by inductively coupled plasma mass spectrometry (ICP-MS), for previously unknown quantities of 33 trace elements. Chapter 4: A comparison of trace element concentrations in bone to natural abundance. Relative incorporation of trace elements is shown to be strongly affected by ionic radius and oxidation state. We identify elements affected by metabolic regulation, and non-metabolically regulated elements suitable for geographic provenance studies. Chapter 5: Trace element compositions of a recent immigrant are compared to those of Rochester residents to determine their potential for geographical provenance studies. Biopurification corrected elemental ratios distinguish the immigrant from Rochester residents, reflecting mixing between NMORB, characteristic of previous domicile, and the Rochester UCC-type soils. Chapter 6: Lead isotopic compositions of a recent immigrant are compared to those of Rochester residents to determine the potential for geographical provenance studies. Lead isotopic compositions of Rochester residents cluster similar to Rochester soil and UCC. The immigrant is strongly differentiated from Rochester residents (>5δ from their mean) by lead isotopic compositions of both cortical and trabecular tissues; long term exposure to a lead source distinct from that of Rochester residents is evidenced. Chapter 7: Bone is shown to incorporate anomalously high concentrations of gadolinium (Gd) from the chelated form used in contrast agents for medical imaging (i.e. MRI, MRA), revealing rapid breakdown of medically dosed chelates to toxic free Gd3+ and incorporation into bone tissues. Incorporation and/or retention of Gd differs between osteoarthritis and fracture patients, indicating a bone pathology effect on metal processing. Chapter 8: Potential for trace elements to affect bone health is investigated through comparison of trace element compositions of patients with osteoarthritis and osteoporosis-related fracture. Toxic metals, total metals, and transition metals are all higher in fracture patients, while Ba concentrations are lower.

Subjects/Keywords: Bone; Biominerals; Bone chemistry; Gadolinium; Trace elements

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Darrah, T. H. (. -. ). (2011). Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/14539

Chicago Manual of Style (16^th Edition):

Darrah, Thomas Henry (1981 - ). “Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance.” 2011. Doctoral Dissertation, University of Rochester. Accessed March 02, 2021. http://hdl.handle.net/1802/14539.

MLA Handbook (7^th Edition):

Darrah, Thomas Henry (1981 - ). “Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance.” 2011. Web. 02 Mar 2021.

Vancouver:

Darrah TH(-). Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1802/14539.

Council of Science Editors:

Darrah TH(-). Inorganic trace element composition of modern human bones : relation to bone pathology and geographical provenance. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/14539

Texas A&M University

13. Chen, Chun-Yu. Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds.

Degree: PhD, Chemistry, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/152575

► Reduced rare-earth (Ln, lanthanide elements) compounds with low-dimensional Ln-Ln-bonded structures are promising candidates for magnetic materials because Ln-Ln-bonded molecules and solids have delocalized 5d electrons… (more)

Subjects/Keywords: Lanthanide elements; Rare-Earth Compounds; Gadolinium

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APA (6^th Edition):

Chen, C. (2014). Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152575

Chicago Manual of Style (16^th Edition):

Chen, Chun-Yu. “Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds.” 2014. Doctoral Dissertation, Texas A&M University. Accessed March 02, 2021. http://hdl.handle.net/1969.1/152575.

MLA Handbook (7^th Edition):

Chen, Chun-Yu. “Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds.” 2014. Web. 02 Mar 2021.

Vancouver:

Chen C. Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969.1/152575.

Council of Science Editors:

Chen C. Synthesis, Computations and Characterizations of Low Dimensional Rare-Earth Compounds. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152575

Anna University

14. Senthil kumaran A. Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;.

Degree: Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/43149

►

From the beginning the uses of solid state laser in the field of science newlineand technology had increased rapidly Present scenario needs laser host newlinematerials… (more)

Subjects/Keywords: Non linear optical; Potassium gadolinium tungstate

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APA (6^th Edition):

A, S. k. (2015). Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/43149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

A, Senthil kumaran. “Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;.” 2015. Thesis, Anna University. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/43149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

A, Senthil kumaran. “Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;.” 2015. Web. 02 Mar 2021.

Vancouver:

A Sk. Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;. [Internet] [Thesis]. Anna University; 2015. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/43149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

A Sk. Growth of pure and rare earth nd3 and yb3 doped double tungstates Kgd wo4 2 and ky wo4 2 and their Characterization;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/43149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Fretellier, Nathalie. Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis.

Degree: Docteur es, Toxicologie, 2013, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2013PA05P609

►

La fibrose systémique néphrogénique (FSN) est une maladie rare et relativement récente, observée uniquement chez des patients souffrant d’insuffisance rénale sévère ou terminale. Elle est… (more)

▼

La fibrose systémique néphrogénique (FSN) est une maladie rare et relativement récente, observée uniquement chez des patients souffrant d’insuffisance rénale sévère ou terminale. Elle est liée à l’administration d’une certaine catégorie de complexes de gadolinium (CG), les CGs thermodynamiquement moins stables, utilisés comme produits de contraste pour l’imagerie par résonance magnétique. L’hypothèse mécanistique la plus couramment citée concerne les effets profibrosants du Gd3+ « libre » après dissociation in vivo des CGs les moins stables mais il n’en existe pas de démonstration formelle. La physiopathologie de cette maladie reste mal connue, notamment par manque de modèles précliniques pertinents. Les travaux de cette thèse répondent donc à la nécessité d’approfondir nos connaissances concernant les relations entre les propriétés physicochimiques des CGs (structure, stabilité) et le risque de toxicité chronique, afin de mieux comprendre leur rôle dans le mécanisme de la FSN. Nous avons mis aux points plusieurs modèles de FSN chez le Rat. Nous avons aussi comparé les effets de toutes les catégories structurales des CGs sur ces modèles. Une toxicité systémique importante et la survenue de lésions cutanées macroscopiques et d’une fibrose du derme sont notées après administration de gadodiamide (un CG linéaire et ionique de faible stabilité), ce qui est cohérent avec le fait que la grande majorité des cas de FSN sont associés à cet agent. Nous avons aussi montré que cette toxicité dépend du degré d’insuffisance rénale et que l’hyperphosphatémie sensibilise les animaux aux effets profibrosants du gadodiamide. Nos données suggèrent donc que ces facteurs associés sont des facteurs de risque de la FSN. Nous avons observé la dissociation progressive in vivo de deux CGs linéaires présentant une faible stabilité, le gadodiamide et l’acide gadopentétique, après administration chez le Rat insuffisant rénal, avec libération de Gd3+ sous forme libre et soluble. Les CGs macrocycliques sont restés stables. Nous avons confirmé cette stabilité sur du sérum de Rat et du sérum humain alors que le gadodiamide se dissocie in vitro. Nos données suggèrent aussi une interaction entre l’ion Gd3+ dissocié à partir du gadodiamide et les protéines sériques. Cette libération de Gd3+ est accélérée en présence d’une forte concentration de phosphate. Globalement, nos résultats suggèrent ainsi un rôle causal du Gd3+ libre dans les lésions cutanées observées chez les animaux insuffisants rénaux. Enfin, nous avons observé l’implication de la voie de signalisation canonique de TGFβ, le marqueur clé de la fibrose, uniquement chez des rats ayant reçu le gadodiamide et dont l’insuffisance rénale est modérée. Nos travaux sont donc en faveur de l’hypothèse mécanistique d’une dissociation des CGs peu stables.

Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing disorder which has been described in patients with severe or end stage renal failure. NSF is associated with prior administration of certain gadolinium complexes (GCs), used as…

Advisors/Committee Members: Massicot, France (thesis director), Idée, Jean-Marc (thesis director).

Subjects/Keywords: Fibrose Systémique Néphrogénique; Gadolinium; Complexes de gadolinium; Dissociation; Relaxométrie; Fibrose; Insuffisance rénale; Nephrogenic systemic fibrosis; Gadolinium; Gadolinium complexes; Dissociation; Relaxometry; Fibrosis; Renal failure; 616.61; 546.416

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fretellier, N. (2013). Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2013PA05P609

Chicago Manual of Style (16^th Edition):

Fretellier, Nathalie. “Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis.” 2013. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed March 02, 2021. http://www.theses.fr/2013PA05P609.

MLA Handbook (7^th Edition):

Fretellier, Nathalie. “Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis.” 2013. Web. 02 Mar 2021.

Vancouver:

Fretellier N. Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2013. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2013PA05P609.

Council of Science Editors:

Fretellier N. Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique : Role of gadolinium complexes in the mechanism of nephrogenic systemic fibrosis. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2013. Available from: http://www.theses.fr/2013PA05P609

16. Haselschwardt, Scott. Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector.

Degree: 2018, University of California – eScholarship, University of California

URL: http://www.escholarship.org/uc/item/8ds7r6x7

► It is now well established that over 80% of the matter in our Universe is comprised of a non-luminous substance known as dark matter. By… (more)

▼ It is now well established that over 80% of the matter in our Universe is comprised of a non-luminous substance known as dark matter. By far the most popular dark matter candidate is the weakly interacting massive particle (WIMP). Attempting to discover the nature of WIMP dark matter through direct detection has been a central activity of experimental physics for at least the last 20 years. To date, no conclusive signal consistent with WIMP interactions has been observed.The LZ (LUX-ZEPLIN) experiment is a second generation direct dark matter detector under construction one mile underground in the Davis Laboratory of the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. LZ will use a 7 tonne central liquid xenon target, arranged in a dual-phase time projection chamber (TPC), to seek evidence for nuclear recoils from a hypothesized galactic flux of WIMPs. Two active detector elements will surround the TPC: a layer of liquid xenon, the xenon skin, optimized to detect γ's, and the outer detector (OD), optimized to detect neutrons. Together, these detectors will tag backgrounds to the sought-after WIMP signal and characterize the background environment around LZ.The OD is comprised of acrylic tanks filled with 17.3 tonnes of LAB-based gadolinium-loaded liquid scintillator (GdLS) that will surround the central cryostat of LZ in a near-hermetic fashion. Its primary function will be to tag neutron single-scatter events in the liquid xenon which could mimic a WIMP dark matter signal. I summarize simulation studies of the OD expected performance as a neutron veto and expected light collection.The rate of single background pulses in the OD is also discussed. The three primary sources of rate in the OD are identified as: LZ detector components, γ-rays from the Davis Laboratory walls, and the radioimpurities in the GdLS. The radioimpurities in the GdLS are particularly troublesome because the OD is sensitive to both the α and β/γ decays of these isotopes. To meet the requirements for the OD, the radioimpurity levels in the GdLS must be kept below ≤ sssim0.07 mBq/kg. This background level corresponds to a rate of \approx50 Hz above an energy threshold of 100 keV.I report on the design and performance of the ``Screener", a small liquid scintillator detector consisting of \approx23 kg of the GdLS to be used in the OD. The Screener was operated in the ultra-low-background environment of the former LUX water shield in the Davis Laboratory at SURF for radioassay of the GdLS. Careful selection of detector materials and use of ultra-low-background PMTs allows the measurement of a variety of radioimpurities. The ¹⁴{C}/¹²{C} ratio in the scintillator is measured to be (2.83±0.06{(stat.)}±0.01{(sys.)}) × 10^-17. Use of pulse shape discrimination allows the concentration of isotopes throughout the ²³⁸{U}, ²³⁵{U}, and ²³²{Th} chains to be measured by fitting the collected spectra from…

Subjects/Keywords: Particle physics; dark matter; gadolinium; liquid scintillator

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APA (6^th Edition):

Haselschwardt, S. (2018). Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector. (Thesis). University of California – eScholarship, University of California. Retrieved from http://www.escholarship.org/uc/item/8ds7r6x7

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haselschwardt, Scott. “Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector.” 2018. Thesis, University of California – eScholarship, University of California. Accessed March 02, 2021. http://www.escholarship.org/uc/item/8ds7r6x7.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haselschwardt, Scott. “Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector.” 2018. Web. 02 Mar 2021.

Vancouver:

Haselschwardt S. Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector. [Internet] [Thesis]. University of California – eScholarship, University of California; 2018. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/8ds7r6x7.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haselschwardt S. Radioassay of Gadolinium-Loaded Liquid Scintillator and Other Studies for the LZ Outer Detector. [Thesis]. University of California – eScholarship, University of California; 2018. Available from: http://www.escholarship.org/uc/item/8ds7r6x7

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

17. Sharples, Joseph William. Cooling rapidly and relaxing slowly with 4f ions.

Degree: PhD, 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/cooling-rapidly-and-relaxing-slowly-with-4f-ions(fab0aa0f-1ab7-4016-9d97-5edf6a629fa8).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607395

► Anisotropic magnetic materials have been proposed over the past twenty years or so as candidates for high density storage, so-called Single-Molecule Magnets (SMMs). These may… (more)

Subjects/Keywords: 546; Magnetocaloric; SMM; Gadolinium; Dysprosium; Lanthanide; Magnetism

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APA (6^th Edition):

Sharples, J. W. (2013). Cooling rapidly and relaxing slowly with 4f ions. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/cooling-rapidly-and-relaxing-slowly-with-4f-ions(fab0aa0f-1ab7-4016-9d97-5edf6a629fa8).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607395

Chicago Manual of Style (16^th Edition):

Sharples, Joseph William. “Cooling rapidly and relaxing slowly with 4f ions.” 2013. Doctoral Dissertation, University of Manchester. Accessed March 02, 2021. https://www.research.manchester.ac.uk/portal/en/theses/cooling-rapidly-and-relaxing-slowly-with-4f-ions(fab0aa0f-1ab7-4016-9d97-5edf6a629fa8).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607395.

MLA Handbook (7^th Edition):

Sharples, Joseph William. “Cooling rapidly and relaxing slowly with 4f ions.” 2013. Web. 02 Mar 2021.

Vancouver:

Sharples JW. Cooling rapidly and relaxing slowly with 4f ions. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Mar 02]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/cooling-rapidly-and-relaxing-slowly-with-4f-ions(fab0aa0f-1ab7-4016-9d97-5edf6a629fa8).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607395.

Council of Science Editors:

Sharples JW. Cooling rapidly and relaxing slowly with 4f ions. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/cooling-rapidly-and-relaxing-slowly-with-4f-ions(fab0aa0f-1ab7-4016-9d97-5edf6a629fa8).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607395

18. Börlin, Emma. Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar.

Degree: Nursing, 2015, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103944

► Bakgrund: Inom röntgenverksamhet används kontrastmedel som ett hjälpmedel för att påvisa skillnader mellan vävnader i kroppen. Gadoliniumbaserade kontrastmedel används till större delen vid MR… (more)

Subjects/Keywords: MRT; Biverkningar; Gadolinium; Kontrastmedel; Gadoliniumbaserade kontrastmedel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Börlin, E. (2015). Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Börlin, Emma. “Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar.” 2015. Thesis, Umeå University. Accessed March 02, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Börlin, Emma. “Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar.” 2015. Web. 02 Mar 2021.

Vancouver:

Börlin E. Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar. [Internet] [Thesis]. Umeå University; 2015. [cited 2021 Mar 02]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Börlin E. Biverkningar vid administrering av gadoliniumkontrastmedel vid MRT-undersökningar. [Thesis]. Umeå University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rice University

19. Taheri, Nasim. Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications.

Degree: PhD, Natural Sciences, 2016, Rice University

URL: http://hdl.handle.net/1911/96531

► Of the recent biomedical studies devoted to the development of medical imaging techniques, magnetic resonance imaging (MRI) has been the subject of increased interest. MRI… (more)

▼ Of the recent biomedical studies devoted to the development of medical imaging techniques, magnetic resonance imaging (MRI) has been the subject of increased interest. MRI is a powerful diagnostic tool that offers detailed, high-resolution anatomical information by monitoring the relaxation rate of water protons in the presence of a strong magnetic field. However, two objectives that have yet to be fully achieved with MRI include generating efficient contrast and enhancing imaging sensitivity to a level that enables differentiating healthy tissue from malignant tissue. Developing an effective MRI contrast to enhance image quality has therefore become crucial to improving this promising technique. This thesis examines the performance of surface engineered gadolinium oxide nanocrystals as T1 MRI contrast agents. Gadolinium oxide nanocrystals are formed at high temperatures in organic solvents and phase transferred into biological media using a novel sulfonic acid copolymer. The surface engineered gadolinium oxide nanocrystals were designed to exploit the plate-like geometry of nanocrystals to form surfaces that are both accessible to water and effective at preventing particle-particle aggregation. The crystals’ anisotropic shape suggests that the gadolinium surface atoms on the thin plate edges can remain uncoated and thus available to water. The relaxivities of these materials are one order of magnitude (15 times) larger than commercial T1 contrast agents and other gadolinium-containing nanoparticles. The magnetic field dependence of their relaxation rates and the relatively weak size dependence of their relaxivity suggest that inner-sphere water relaxation at the edges of the nanocrystal are responsible for the high relaxation rates. These surfaces have significant potential as T1 MRI contrast agents, offering a non-invasive imaging alternative with numerous applications, including detection and characterization of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), and tracking of stem cells in embryos. As part of this thesis, we introduced surface functionalized gadolinium oxide nanocrystals with three different surface coatings—each with unique characteristics. These materials were chosen because they are stable in relevant biological conditions while posing distinct responses in different environments. We examined the effect of surface coating, salt, and protein on the performance of gadolinium oxide nanocrystals as MRI contrast agents. We found that their behavior was altered in plasma, implying that surface coating has an important effect on their interactions with proteins. Moreover, we showed that, unlike other studies in deionized water in which relaxivity has a linear dependency, forming strong protein binding enables relaxivity measurement to be dependent on gadolinium concentration. Finally, we studied the possible cytotoxic effects of gadolinium oxide nanocrystals in vitro and in vivo. Since gadolinium ion is a heavy metal, it is important to ensure that it is shielded with… Advisors/Committee Members: Colvin, Vicki L. (advisor).

Subjects/Keywords: Gadolinium Oxide Nanocrystals; MRI; Contrast Agent; Biomedical

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APA (6^th Edition):

Taheri, N. (2016). Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/96531

Chicago Manual of Style (16^th Edition):

Taheri, Nasim. “Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications.” 2016. Doctoral Dissertation, Rice University. Accessed March 02, 2021. http://hdl.handle.net/1911/96531.

MLA Handbook (7^th Edition):

Taheri, Nasim. “Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications.” 2016. Web. 02 Mar 2021.

Vancouver:

Taheri N. Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications. [Internet] [Doctoral dissertation]. Rice University; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1911/96531.

Council of Science Editors:

Taheri N. Gadolinium Oxide Nanocrystals: Synthesis, Characterization, and Applications. [Doctoral Dissertation]. Rice University; 2016. Available from: http://hdl.handle.net/1911/96531

University of Florida

20. Sternberg, James Scott. Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents.

Degree: MS, Chemistry, 2015, University of Florida

URL: https://ufdc.ufl.edu/UFE0049319

Subjects/Keywords: contrast; gadolinium; zirconium

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APA (6^th Edition):

Sternberg, J. S. (2015). Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0049319

Chicago Manual of Style (16^th Edition):

Sternberg, James Scott. “Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents.” 2015. Masters Thesis, University of Florida. Accessed March 02, 2021. https://ufdc.ufl.edu/UFE0049319.

MLA Handbook (7^th Edition):

Sternberg, James Scott. “Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents.” 2015. Web. 02 Mar 2021.

Vancouver:

Sternberg JS. Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents. [Internet] [Masters thesis]. University of Florida; 2015. [cited 2021 Mar 02]. Available from: https://ufdc.ufl.edu/UFE0049319.

Council of Science Editors:

Sternberg JS. Gadolinium Doped Zirconium Phosphate Nanoparticles for Use as Mri Contrast Agents. [Masters Thesis]. University of Florida; 2015. Available from: https://ufdc.ufl.edu/UFE0049319

University of Melbourne

21. Tse, Nicholas Man Kei. Nanostructured nanoparticulate contrast agent for medical imaging.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38262

► Magnetic resonance imaging (MRI) is one of the most common and non-invasive medical diagnostics technique used in modern medicine. The contrast of the MRI image… (more)

▼ Magnetic resonance imaging (MRI) is one of the most common and non-invasive medical diagnostics technique used in modern medicine. The contrast of the MRI image generated may be greatly improved with the use of contrast agents which are entities that facilitates the relaxation of nuclear magnetic resonance energy. Paramagnetic elements such as gadolinium have been traditionally employed to enhance the contrast of longitudinal (T1) weighted MRI images. The performance (relaxivity) of these gadolinium based contrast agents are governed by parameters which include the degree of hydration, the molecular tumbling rate and the localised gadolinium (and dopant) concentration. This thesis examined the postulate of improved MRI contrast ability by including the MRI active species, gadolinium, into a porous nanoparticulate matrix. The porous nanoparticles matrix were predominately mesoporous silicate based frameworks. To investigate this multivariate problem, high throughput combinatorial synthesis and characterisation techniques were employed. Using a robotic setup, a library of porous silicates incorporated with gadolinium were synthesised and subsequently structurally characterised using the small and wide angle X-ray scattering beamline at the Australian Synchrotron. The performance of the materials were subsequently characterised using a clinical MRI scanner at the Royal Melbourne Hospital. The gadolinium doped silicates were found to be better performing than the commercially available gadolinium based contrast agent. The synthetic and characterisation techniques were demonstrated to be applicable in examining the effect of co-dopants (aluminium, europium and terbium) has on the relaxivity. Using this approach, additional libraries of silicate nanoparticles with mixed dopant were synthesised and characterised for their MRI activities. The MRI performance was found to be significantly modified in the presence of the additive dopant. Materials with the additional lanthanides incorporated exhibited luminescence responses, enabling the MRI contrast agents to function as bimodal (MRI and luminescence) medical imaging probes. To further investigate the effect porosity has on the MRI activities of these nanoparticlular frameworks, a range of silicate samples with varying pore sizes and pore orderings were synthesised using a low-throughput methodology. The MRI performance was found to be dependent on pore size and pore ordering of the template silicate framework. The MRI performance was significantly dependent on both the gadolinium loading and the type of porous network for materials with pore-pore connectivity. This may be due to the increased hydration of the pore walls within the porous network. The dependency between the relaxivity and the porosity was not observed for a different type of porous framework. The MRI activity of analogous ordered…

Subjects/Keywords: MRI contrast agents; high-throughput; silicates; gadolinium

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APA (6^th Edition):

Tse, N. M. K. (2013). Nanostructured nanoparticulate contrast agent for medical imaging. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38262

Chicago Manual of Style (16^th Edition):

Tse, Nicholas Man Kei. “Nanostructured nanoparticulate contrast agent for medical imaging.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 02, 2021. http://hdl.handle.net/11343/38262.

MLA Handbook (7^th Edition):

Tse, Nicholas Man Kei. “Nanostructured nanoparticulate contrast agent for medical imaging.” 2013. Web. 02 Mar 2021.

Vancouver:

Tse NMK. Nanostructured nanoparticulate contrast agent for medical imaging. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11343/38262.

Council of Science Editors:

Tse NMK. Nanostructured nanoparticulate contrast agent for medical imaging. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38262

Kansas State University

22. Javier, Abello. Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model.

Degree: PhD, Department of Food, Nutrition, Dietetics and Health, 2018, Kansas State University

URL: http://hdl.handle.net/2097/39343

► Human umbilical cord-derived mesenchymal stromal cells (HUC-MSCs) have an enormous therapeutic potential because of their immunomodulatory and anti-inflammatory properties. However, there are limitations for their… (more)

Subjects/Keywords: Extracellular vesicles; mouse osteosarcoma model; gadolinium nanoparticle

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APA (6^th Edition):

Javier, A. (2018). Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model. (Doctoral Dissertation). Kansas State University. Retrieved from http://hdl.handle.net/2097/39343

Chicago Manual of Style (16^th Edition):

Javier, Abello. “Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model.” 2018. Doctoral Dissertation, Kansas State University. Accessed March 02, 2021. http://hdl.handle.net/2097/39343.

MLA Handbook (7^th Edition):

Javier, Abello. “Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model.” 2018. Web. 02 Mar 2021.

Vancouver:

Javier A. Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model. [Internet] [Doctoral dissertation]. Kansas State University; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2097/39343.

Council of Science Editors:

Javier A. Effect of extracellular vesicles on cancer cell lines in vitro and biodistribution in an ectopic osteosarcoma mouse model. [Doctoral Dissertation]. Kansas State University; 2018. Available from: http://hdl.handle.net/2097/39343

Georgia State University

23. Purser, Corrie N. Protein Modification of Designed MRI Contrast Agents.

Degree: MS, Chemistry, 2015, Georgia State University

URL: https://scholarworks.gsu.edu/chemistry_theses/84

► Protein based contrast agents (ProCAs) developed by the Yang lab exhibit unique capabilities in enabling magnetic resonance imaging (MRI) with significantly improved sensitivity and… (more)

▼ Protein based contrast agents (ProCAs) developed by the Yang lab exhibit unique capabilities in enabling magnetic resonance imaging (MRI) with significantly improved sensitivity and targeting capabilities by utilizing biomarkers which can target various carcinomas in animals. Further clinical in vivo human applications require modifications of these designed contrast agents to further improve organ and tissue biodistribution, biomarker and cell targeting capabilities, and reduction of immunogenicity. The aim of this thesis is to develop a novel protein modification on ProCA by glycosylation to improve liver distribution by targeting liver receptor, asialoglycoprotein receptor (ASGPR). Rat and humanized first generation and humanized third generation ProCA were expressed and purified using either glutathione s-transferase (GST) tagged or taggless methods. Rat ProCA1, rProCA1, was then used to optimize glycan modification with glycosylation achieved at the highest level using a 100:1 molar ratio and three lysine residues. Similar to non-modified rProCA1 and PEGylated rProCA1, metal binding affinity of gadolinium for glycan modified rProCA1, Glyco-rProCA1, was found to be 9.49 x 10^-12 M, and relaxivity was found to be greater than clinically available contrast agents with 34.08 and 42.67 mM^-1s^-1for r₁ and r₂ respectively. Glycosylation of rProCA1 has significantly increased human serum stability, and we have achieved significant liver MRI enhancement via tail vein injection due to high ASGPR expression in the liver altering biodistribution of glycan modified ProCA, and we have also imaged uptake in the secretory glands. These biodistribution changes were noted by immunohistochemistry (IHC) staining which was found to stain liver sinusoid with spaces in between. The distribution to the liver was further confirmed via inductively coupled plasma optical emission spectrometry (ICP-OES) which shows Glyco-rProCA1 has significant uptake of gadolinium in the liver tissue. This study represents the first achievement of in vivo liver imaging by glycosylation using a lactose targeting moiety covalently bonded to protein contrast agents for MRI showing promise for future more specific targeting or whole body imaging capabilities. Advisors/Committee Members: Jenny J. Yang, Peng George Wang, Siming Wang.

Subjects/Keywords: Expression; Glycosylation; Gadolinium; Metal binding; Relaxivity; Humanization

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APA (6^th Edition):

Purser, C. N. (2015). Protein Modification of Designed MRI Contrast Agents. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/chemistry_theses/84

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Purser, Corrie N. “Protein Modification of Designed MRI Contrast Agents.” 2015. Thesis, Georgia State University. Accessed March 02, 2021. https://scholarworks.gsu.edu/chemistry_theses/84.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Purser, Corrie N. “Protein Modification of Designed MRI Contrast Agents.” 2015. Web. 02 Mar 2021.

Vancouver:

Purser CN. Protein Modification of Designed MRI Contrast Agents. [Internet] [Thesis]. Georgia State University; 2015. [cited 2021 Mar 02]. Available from: https://scholarworks.gsu.edu/chemistry_theses/84.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Purser CN. Protein Modification of Designed MRI Contrast Agents. [Thesis]. Georgia State University; 2015. Available from: https://scholarworks.gsu.edu/chemistry_theses/84

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

24. Seidemann, Laura Ruth. An investigation of gadolinium mixed halides.

Degree: 1976, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:12930

Thesis () – Michigan State University. Dept. of Chemistry,

Subjects/Keywords: Gadolinium earths; Halides

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APA (6^th Edition):

Seidemann, L. R. (1976). An investigation of gadolinium mixed halides. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:12930

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seidemann, Laura Ruth. “An investigation of gadolinium mixed halides.” 1976. Thesis, Michigan State University. Accessed March 02, 2021. http://etd.lib.msu.edu/islandora/object/etd:12930.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seidemann, Laura Ruth. “An investigation of gadolinium mixed halides.” 1976. Web. 02 Mar 2021.

Vancouver:

Seidemann LR. An investigation of gadolinium mixed halides. [Internet] [Thesis]. Michigan State University; 1976. [cited 2021 Mar 02]. Available from: http://etd.lib.msu.edu/islandora/object/etd:12930.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seidemann LR. An investigation of gadolinium mixed halides. [Thesis]. Michigan State University; 1976. Available from: http://etd.lib.msu.edu/islandora/object/etd:12930

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

25. Thorsell, David Linden. Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K.

Degree: PhD, Graduate School, 1971, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486730913206205

Subjects/Keywords: Chemistry; Deuterium; Gadolinium

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APA (6^th Edition):

Thorsell, D. L. (1971). Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486730913206205

Chicago Manual of Style (16^th Edition):

Thorsell, David Linden. “Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K.” 1971. Doctoral Dissertation, The Ohio State University. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486730913206205.

MLA Handbook (7^th Edition):

Thorsell, David Linden. “Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K.” 1971. Web. 02 Mar 2021.

Vancouver:

Thorsell DL. Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K. [Internet] [Doctoral dissertation]. The Ohio State University; 1971. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486730913206205.

Council of Science Editors:

Thorsell DL. Part I. Electron paramagnetic resonance studies of Gd³⁺ in single crystals ; Part II. An EPR investigation of deuterium isotope effects on the zero-field splittings of optically excited triplet molecules in single crystals at 77 K. [Doctoral Dissertation]. The Ohio State University; 1971. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486730913206205

Ryerson University

26. Keldani, Zaid. Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study.

Degree: 2017, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A7036

► Elevated gadolinium levels in patients with healthy renal function exposed to gadolinium based contrast agents (GBCA) have been confirmed by studies in the literature. Though… (more)

▼ Elevated gadolinium levels in patients with healthy renal function exposed to gadolinium based contrast agents (GBCA) have been confirmed by studies in the literature. Though the potential long-term effects of the retained gadolinium are still unknown, symptoms such as bone and joint pain have been reported in some subjects. As detecting the presence of gadolinium in vivo is required to diagnose toxicity related medical conditions, a 109Cd based X-ray fluorescence (XRF) bone gadolinium measurement system has been previously developed. The current method is dependent on geometrical factors and other interpatient factors, such as the size and shape of the bone and the tissue thickness overlying the measurement site, which reduces the robustness of the measurement system and causes the need for correction factors. It was previously shown that the successful use of the coherent normalization procedure can eliminate the need for such corrections and is conditional on four criteria that must be met. When detecting gadolinium two of the four criteria are not satisfied which makes further investigation of the method required. This work investigates the feasibility of the coherent normalization method to correct for the effect of varying overlying tissue thickness of an adult population through Monte Carlo simulations. The coherent normalization method was studied as a function of overlying tissue thickness (OTT) to represent varying body types. The average coherent ratio (Gd K X-ray counts/Coherent counts) was found to be 0.717 ± 0.025 and the normalization resulted in a line with a slope of -0.0053± 0.0040 which is insignificant at the 95% confidence level (p = 0.43) suggesting the validity of the method. Additionally, this thesis provides a theoretical explanation of the feasibility of the method regardless of not fulfilling all four criteria, through introducing the Secondary Fluence Fluorescence Factor (SFFF) and separating fluence components, primary and secondary, contributing to the fluorescence of gadolinium. Advisors/Committee Members: Gräfe, James (Thesis advisor).

Subjects/Keywords: Biomedical engineering; X-ray spectroscopy; Fluorescence spectroscopy; Gadolinium compounds; Gadolinium; Medical technology

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APA (6^th Edition):

Keldani, Z. (2017). Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A7036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keldani, Zaid. “Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study.” 2017. Thesis, Ryerson University. Accessed March 02, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A7036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keldani, Zaid. “Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study.” 2017. Web. 02 Mar 2021.

Vancouver:

Keldani Z. Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study. [Internet] [Thesis]. Ryerson University; 2017. [cited 2021 Mar 02]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A7036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keldani Z. Investigating The Coherent Normalization Method For A Bone Gadolinium X-ray Fluorescence Measurement System: A Monte Carlo Study. [Thesis]. Ryerson University; 2017. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A7036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Law, Frédéric. Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination.

Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2017, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2017SACLS138

►

L’arrivée des nanobiotechnologies en cancérologie apporte un nouveau souffle dans le traitement des cancers. Les travaux réalisés par Olivier Tillement et ses collaborateurs ont permis… (more)

▼

L’arrivée des nanobiotechnologies en cancérologie apporte un nouveau souffle dans le traitement des cancers. Les travaux réalisés par Olivier Tillement et ses collaborateurs ont permis de montrer que les nanoparticules de gadolinium (GdBN) sont capables d’augmenter d’une part la qualité d’imagerie par résonance magnétique (IRM) mais également d’augmenter les effets des rayonnements ionisants (IR) sur les tumeurs. Des études précliniques sur des tumeurs de glioblastome greffées sur des souris C57BL/6 ont permis de révéler la capacité de la combinaison GdBN+IR à favoriser une régression tumorale. Néanmoins, les processus de morts cellulaires impliqués sont partiellement connus. Nos résultats ont permis de démontrer que ce traitement produit un stress oxydatif généré par une NADPH oxydase. Ce stress oxydatif déclenche un arrêt de la prolifération des cellules qui dépend de la protéine p21 et qui déclenche un processus de sénescence cellulaire et le cannibalisme des cellules irradiées. Le cannibalisme cellulaire ainsi déclenché aboutit à l’élimination de cellules internalisées. Ainsi, l’ensemble de ces résultats nous a permis de révéler que la combinaison des GdBN et de l’irradiation contribue à l’élimination de cellules cancéreuses en déclenchant la sénescence des cellules irradiées ainsi qu’un mécanisme original de mort cellulaire, le cannibalisme cellulaire.

The nanotechnology aims to help in the cancer treatment. Olivier Tillement and his colleagues have demonstrated that the Gadolinium-Based Nanoparticle (GdBN) can improve Magnetic Resonance Imaging (MRI) and increase radiotherapy effects. Pre-clinical studies show that the combination of GdBN with ionizing radiation is associated with tumor regression. However, the molecular and cellular processes involved this biological effect remain to be elucidated. Our results show that the combination of GdBN with IR generates oxidative stress through NADPH oxidase-dependent mechanisms, leads to cellular senescence and induces the cannibalistic activity of irradiated cells. Altogether, these results reveal that the combination of GdBN with IR promotes the killing of irradiated cells through the induction of cellular senescence and cellular cannibalism.

Advisors/Committee Members: Perfettini, Jean-Luc (thesis director).

Subjects/Keywords: Nanoparticule; Gadolinium; Radiothérapie; Morts cellulaires; Cancer; Nanoparticle; Gadolinium; Radiotherapy; Cell death; Cancer

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APA (6^th Edition):

Law, F. (2017). Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2017SACLS138

Chicago Manual of Style (16^th Edition):

Law, Frédéric. “Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination.” 2017. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 02, 2021. http://www.theses.fr/2017SACLS138.

MLA Handbook (7^th Edition):

Law, Frédéric. “Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination.” 2017. Web. 02 Mar 2021.

Vancouver:

Law F. Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2017. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2017SACLS138.

Council of Science Editors:

Law F. Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales : Effect of the combination of gadolinium based-nanoparticle and radiotherapy on cell death elimination. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2017. Available from: http://www.theses.fr/2017SACLS138

28. Rigaux, Guillaume. Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI.

Degree: Docteur es, Sciences - STS, 2015, Reims

URL: http://www.theses.fr/2015REIMS026

►

L'objectif poursuivi au cours de ce travail est l'élaboration de nanoparticules biocompatibles à visée diagnostique (IRM) et thérapeutique (PDT). Dans ce but, un protocole de… (more)

▼

L'objectif poursuivi au cours de ce travail est l'élaboration de nanoparticules biocompatibles à visée diagnostique (IRM) et thérapeutique (PDT). Dans ce but, un protocole de nanoprécipitation a été optimisé pour obtenir de façon quantitative et reproductible, des nanoparticules de PLGA de diamètre compatible avec une injection par voie parentérale. Cette formulation a été employée avec succès pour l'encapsulation d'un chélate lipophile de Gd(III), pour l'encapsulation d'un photosensibilisateur (m-THPC) et pour la co-encapsulation de ces deux substances actives. Les formulations optimales permettent d'obtenir des efficacités d'encapsulation de 7 et 46 % en chélate de gadolinium et m-THPC respectivement. La cytotoxicité et la photocytotoxicité des [email protected] ont été testées sur deux lignées cellulaires (C6 et fibroblastes) et les résultats obtenus montrent que les propriétés photocytotoxiques du m-THPC sont maintenues après l'encapsulation. L'efficacité IRM de ces nanoparticules a aussi été évaluée et les mesures NMRD et IRM à 3T montrent que l'encapsulation des chélates de gadolinium améliore leur capacité à générer un contraste en mode T1 et donc la qualité des images.

This work aimed at the synthesis of biocompatible nanoparticles for PDT and MRI applications. To reach this goal, a nanoprecipitation technique was optimized using only biocompatible starting materials. This technique allowed the preparation, in a reproducible and quantitative manner of PLGA nanoparticles, compatible with parenteral injections. This formulation was successfully applied to encapsulate a lipophilic Gd(III) chelate, a photosensitizer (m-THPC) and to co-encapsulate these two substances. Optimal formulations showed encapsulation yields of 7 and 46 % for the gadolinium chelate and m-THPC, respectively. Cytotoxicity and photocytotoxicity experiments performed for two different cell lines (C6 cells and fibroblasts) incubated with [email protected] nanoparticles showed that m-THPC photocytotoxicity was maintained after its encapsulation. MRI efficacy of [email protected] nanoparticles was also evaluated by NMRD measurements and 3T MRI images. The corresponding results indicated that gadolinium chelate encapsulation improved its tendency to generate an efficient T1 contrast and consequently, enhanced the image contrast.

Advisors/Committee Members: Chuburu, Françoise (thesis director).

Subjects/Keywords: Nanoparticules de PLGA; Nanoprécipitation; Photosensibilisateurs; Pdt; Gadolinium; Irm; PLGA nanoparticles; Nanoprecipitation; Photosensitizer; Pdt; Gadolinium; Mri

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APA (6^th Edition):

Rigaux, G. (2015). Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI. (Doctoral Dissertation). Reims. Retrieved from http://www.theses.fr/2015REIMS026

Chicago Manual of Style (16^th Edition):

Rigaux, Guillaume. “Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI.” 2015. Doctoral Dissertation, Reims. Accessed March 02, 2021. http://www.theses.fr/2015REIMS026.

MLA Handbook (7^th Edition):

Rigaux, Guillaume. “Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI.” 2015. Web. 02 Mar 2021.

Vancouver:

Rigaux G. Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI. [Internet] [Doctoral dissertation]. Reims; 2015. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2015REIMS026.

Council of Science Editors:

Rigaux G. Elaboration, caractérisation et évaluation biologique de nanoparticules biocompatibles pour la thérapie photodynamique et l’imagerie IRM : Elaboration, characterization and biological evaluation of biocompatible nanoparticles for photodynamic therapy and MRI. [Doctoral Dissertation]. Reims; 2015. Available from: http://www.theses.fr/2015REIMS026

University of Vienna

29. Devishvili, Anton. Magnetic properties of Gd3+ based systems.

Degree: 2010, University of Vienna

URL: http://othes.univie.ac.at/11710/

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Aufgrund ihres grossen Spinmoments (S = 7/2) sind gadoliniumhaltige Verbindungen von grossem wissenschaftlichen Interesse. Die halbgefuellte 4f Schale fuehrt zu einer kugelsymmetrischen Ladungsverteilung ohne Orbitalmoment… (more)

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Aufgrund ihres grossen Spinmoments (S = 7/2) sind gadoliniumhaltige Verbindungen von grossem wissenschaftlichen Interesse. Die halbgefuellte 4f Schale fuehrt zu einer kugelsymmetrischen Ladungsverteilung ohne Orbitalmoment (L = 0) und es ist keine magnetokristalline Anisotropie zu erwarten. In einer einfachen Molekularfeldtheorie ist ausschliesslich die Spin-Spin-Wechselwirkung anisotrop. In dieser Arbeit wurde die magnetische Strukturen verschiedener gadoliniumhaltiger Verbindungen mit Neutronen gemessen und modelliert. Suszeptibilitaets- und Magnetisierungsmessungen weisen darauf hin, dass die orthorhombische Verbindung GdCu6 unterhalb Tn = 16 K antiferromagnetisch geordnet ist. Eine inkommensurable magnetische Ordnung konnte in der Tat durch Neutronendiffraktion bestimmt und mittels einer einfachen Molekularfeldtheorie beschrieben werden. Demgegenueber scheitert eine solche Beschreibung im Fall der tetragonalen Verbindung GdRu2Si2. Schon in Suszeptibilitaets- und Magnetisierungsmessungen beobachtet man eine ungewoehnlich hohe Anisotropie und mehrere magnetische Phasen. Die magnetische Struktur konnte mit Neutronen- und magnetische Roentgenstreuung im Detail bestimmt und nur unter Einbeziehung einer isotropen biquadratischen und einer anisotropen bilinearen Wechselwirkung zufriedenstellend modelliert werden. Diesen beiden sowie allen weiteren untersuchten Verbindungen ist eine inkommensurable Struktur mit grosser Periodenlaenge gemeinsam.

Gd3+ based rare earth systems are of particular interest due to their large spin (S=7/2). The 4f shell is half filled, implying spherically symmetric charge density and no orbital moment (L=0). There are no first order crystal field effects present in this type of systems, therefore, no magnetocrystalline anisotropy is expected. The standard model of rare earth magnetism suggests a relatively simple mean field model treatment which predicts only spin-spin interaction magnetism with classical dipolar anisotropy. A magnetic structure study of several Gd compounds is presented in this thesis. The structure investigation has been performed with neutron scattering techniques at the ILL accompanied by bulk measurements and numerical analysis. Magnetic properties of GdCu6 (orthorhombic with spacegroup P n m a) can be described well within this model. Susceptibility and magnetization indicate antiferromagnetic order below the Neel temperature Tn =16 K. Neutron diffraction suggests the presence of a long period possibly incommensurate structure of (h 0 0) type propagation vector (0.16 < h < 0.25). The results of the neutron diffraction are in accordance with the expectations from the mean field model. In contrast to GdCu6, the tetragonal antiferromagnet GdRu2Si2(I 4/m m m) is not well explained within the framework of the standard model of rare earth magnetism. Magnetization and susceptibility measured along the different crystallographic axes show an unusually high anisotropy and some additional unexpected features in the magnetic phase diagram. Neutron and magnetic X-ray…

Subjects/Keywords: 33.75 Magnetische Materialien; 33.61 Festkörperphysik; 33.16 Elektrizität, Magnetismus; Gadolinium / Neutronenstreuung / Antiferromagnet; Gadolinium / Neutron / scattering / Antiferromagnetic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Devishvili, A. (2010). Magnetic properties of Gd3+ based systems. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/11710/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Devishvili, Anton. “Magnetic properties of Gd3+ based systems.” 2010. Thesis, University of Vienna. Accessed March 02, 2021. http://othes.univie.ac.at/11710/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Devishvili, Anton. “Magnetic properties of Gd3+ based systems.” 2010. Web. 02 Mar 2021.

Vancouver:

Devishvili A. Magnetic properties of Gd3+ based systems. [Internet] [Thesis]. University of Vienna; 2010. [cited 2021 Mar 02]. Available from: http://othes.univie.ac.at/11710/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Devishvili A. Magnetic properties of Gd3+ based systems. [Thesis]. University of Vienna; 2010. Available from: http://othes.univie.ac.at/11710/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Letouzey, Vincent. Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse.

Degree: Docteur es, Gynécologie obstétrique, 2011, Université Montpellier I

URL: http://www.theses.fr/2011MON1T030

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Les interventions chirurgicales avec prothèses pour défauts de soutènement ont déjà nécessité l'implantation de plus d'un million de prothèses dans le monde. L'indication des prothèses… (more)

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Les interventions chirurgicales avec prothèses pour défauts de soutènement ont déjà nécessité l'implantation de plus d'un million de prothèses dans le monde. L'indication des prothèses de soutènement synthétiques non résorbables a permis de diminuer les récidives à court terme mais présente une incidence non négligeable de complications postopératoires. Le taux de réinterventions reste encore trop élevé. Cette thèse a pour objectif d'apporter de nouvelles propriétés à ces prothèses de polypropylène, pour à la fois améliorer leur résistance à l'infection et permettre leur visualisation en IRM clinique. Des treillis libérant des antibiotiques de façon contrôlée sont développés par enduction de polymère dégradable et biocompatible contenant des antibiotiques. Cette enduction présente une activité antibactérienne in vivo significative. Une autre enduction de polymères dégradables ou non dégradables, par une technique de pulvérisation par aérographie, permet une visualisation en IRM des treillis in vitro et après implantation. La stabilité du polymère greffé avec l'agent de contraste autorise une visualisation des treillis pendant au moins douze mois.

Surgical procedures with synthetic meshes have yet allowed more than one million operations. Non absorbable synthetic mesh used has permitted to decrease clinical recurrence at short term, but post operative complications still exist. Re operation rate is still too high. This study aims to develop new properties for those polypropylene meshes, such as infection resistance and MRI visualization. Meshes with controlled release of antibiotics were obtained after polymer coating and showed a significant in vivo antibacterial effect. Another mesh coating, with an aerograph procedure, has allowed MRI mesh visualization. To visualize by MRI, meshes after implantation, two new MRI visible polymer (degradable and non degradable) were coated onto meshes using an airbrush system. This coating allows the visualization of meshes in vitro and in vivo with experimental and clinical MR equipments. The stability of the MRI visible polymers permits to in vitro to visualize meshes during at least one year.

Advisors/Committee Members: Tayrac, Renaud de (thesis director).

Subjects/Keywords: Prothèse.; Gadolinium; Irm; Antibiotique; Enduction; Poly(propylène); Poly(propylene); Coating; Antibiotic; Mri; Gadolinium; Mesh

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Letouzey, V. (2011). Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse. (Doctoral Dissertation). Université Montpellier I. Retrieved from http://www.theses.fr/2011MON1T030

Chicago Manual of Style (16^th Edition):

Letouzey, Vincent. “Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse.” 2011. Doctoral Dissertation, Université Montpellier I. Accessed March 02, 2021. http://www.theses.fr/2011MON1T030.

MLA Handbook (7^th Edition):

Letouzey, Vincent. “Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse.” 2011. Web. 02 Mar 2021.

Vancouver:

Letouzey V. Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse. [Internet] [Doctoral dissertation]. Université Montpellier I; 2011. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2011MON1T030.

Council of Science Editors:

Letouzey V. Optimisation des prothèses de renfort pariétal dans la cure de prolapsus des organes pelviens : Development of reinforcement parietal meshes for pelvic organ prolapse. [Doctoral Dissertation]. Université Montpellier I; 2011. Available from: http://www.theses.fr/2011MON1T030

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