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1. Panagoulias, Georgiios. Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη.

Degree: 2018, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

Diabetes Mellitus (DM) is a modern plague of humanity. Foot complications are the most serious among DM complications. Diabetic Foot (DF) is the mainstay of foot complications. DF is defined as the foot with ulceration that is associated with neuropathy and/or peripheral arterial disease of the lower limbs in a patient with diabetes.Diabetic neuropathy (DN) is defined as the nerve damage due to DM and may be clinically evident or subclinical. It is characterized as DN after the exclusion of other causes of neuropathy. Clinical studies have repeatedly highlighted the importance of DN as a predisposing factor for ulceration. Recent studies have shown the usefulness and precision of a semi-quantitative method for controlling foot sweating for Diabetic Symmetric Poly-Neuropathy (DSPN) diagnosis. This semi-quantitative method consists of applying an Adhensive Indicator Plaster (AIP) on the plantar surface of each foot, just under at the head of the 1st metatarsal bone. The AIP should be placed on dry skin without callus formation. It contains anhydrous cobalt crystals, which give the plaster a blue color. When the AIP uptakes moisture, it changes its color to pink. When applied to human skin, in case of perspiration loss, the plaster remains blue, in reduced sweat secretion it acquires a picture of a blue-and-pink mosaic, while in normal condition it is fully colored pink.The high degree of reliability and the easiness of use of the IPN suggest that it is proper for self-testing for the identification of peripheral neuropathy in people with DM. The purpose of this study is to examine the predictive value of the above-mentioned semi-quantitative method of sweat excretion in people with DM and its contribution in predicting foot ulceration.221 subjects with DM with and without neuropathy were enrolled in the study. Nobody had any other health problems or was receiving any medication that may altered feet humidity. All patients underwent neurological examination. Neuropathy Disability Score (NDS) was calculated and AIPs were applied on their first visit. Follow-up of the patients was either via telephone or by physical presence. The findings are as follows:1. NDS is the gold standard for prediction of ulceration in the future.2. The AIP has high sensitivity (85%) and extremely high negative predictive value (NPV: 95%) in predicting ulceration as a single method. Its high negative diagnostic value implies that if the result of AIP is normal, then the likelihood of ulceration is extremely low. The result seems to be applicable for up to 7 years.3. If both AIP and NDS are abnormal, then the likelihood of ulceration is 82%. This is attributed to the progressive damage of all the mechanisms of sweating of the legs and nerve degeneration associated with DM.Based on the above, it is proposed that the AIP has to be included in everyday clinical practice as a complementary test to predict foot ulceration in people with diabetes.

Ο Σακχαρώδης Διαβήτης (ΣΔ) αποτελεί σύγχρονη μάστιγα της ανθρωπότητας. Οι επιπλοκές των ποδών είναι…

Subjects/Keywords: Σακχαρώδης διαβήτης; Διαβητικό πόδι; Διαβητικό έλκος; Αυτόνομη διαβητική νευροπάθεια; Διαβητική νευροπάθεια; Ξηροδερμία; Πειφερική Αγγειακή Νόσος των κάτω άκρων; Επίθεμα Neuropad; Αυτοκόλλητο Διαγνωστικό Επίθεμα; Διαβητική Περιφερική Νευροπάθεια; Περιφερική νευροπάθεια; Ιδρώτας; Ιδρωτοποιοί Αδένες; Πόδι; Πους; Εξέλκωση; Δείκτης Νευρολογικής Ανικανότητας; Τηλεφωνική Επικοινωνίας; Τηλεφωνική επανεξέταση; Τηλεφωνική παρακολούθηση; Έλκος; Πέλμα; ΠΟΔΙΑ; Απομυελίνωση; Ιδρωκινητική; Ιδρωκινητική Δυσλειτουργία; Ιδρωκινητική απονεύρωση; Έκκριση ιδρώτα; Ιδρωκινητική λειτουργία; ΔΝΑ; Περιφερική αγγειοπάθεια; Περιφερική αγγειοπάθεια κάτω άκρων; Αυτοκόλλητο Διαγνωστικό Επίθεμα Neuropad; Δυσαυτονομία; Diabetes; Diabetes mellitus; Foot; Ulcer; Ulceration; Foot ulcer; Foot ulceration; Diabetic foot; Diabetic foot ulcer; Diabetic foot ulceration; Feet; Diabetic feet; Peripheral neuropathy; Diabetic peripheral neuropathy; Peripheral arterial disease; Peripheral arterial occlusive disease; Chronic occlusive arterial disease; Indicator plaster test; Indicator plaster test Neuropad; Neuropad; Telephone; Telephone intervention programm; Telephone follow-up; Follow-up; Plantar sweating; Sweat; Sweating; Foot sweat; Xerosis; Xerodermia; Diabetic autonoomic neuropathy; Diabetic neuropathy; Sudomotor; Sudomotor function testing; Sudomotor neuropathy; Sudomotor function; Sudomotor denervation; Neuropathy Disability Score; NDS; Sweat Gland; sweat Glands

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APA (6th Edition):

Panagoulias, G. (2018). Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/42972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Panagoulias, Georgiios. “Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη.” 2018. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed December 14, 2019. http://hdl.handle.net/10442/hedi/42972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Panagoulias, Georgiios. “Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη.” 2018. Web. 14 Dec 2019.

Vancouver:

Panagoulias G. Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10442/hedi/42972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Panagoulias G. Σχέση μεταξύ της ξηροδερμίας των άκρων ποδών με την εμφάνιση ελκών σε άτομα με σακχαρώδη διαβήτη: μια προοπτική μελέτη. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. Available from: http://hdl.handle.net/10442/hedi/42972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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