subject:(Flavone)

Texas A&M University

1. Taleon Alban, Victor Manuel. Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption.

Degree: PhD, Food Science and Technology, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151146

► Sorghum contains many phenolic compounds which have potential antioxidant, anti-inflammatory, and chemopreventive properties as well as natural colorants in foods. Phenolic compounds of stalks, sheaths,… (more)

Subjects/Keywords: Sorghum; flavone; 3-deoxyanthocyanidins; caco-2

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APA (6^th Edition):

Taleon Alban, V. M. (2013). Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151146

Chicago Manual of Style (16^th Edition):

Taleon Alban, Victor Manuel. “Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption.” 2013. Doctoral Dissertation, Texas A&M University. Accessed January 24, 2021. http://hdl.handle.net/1969.1/151146.

MLA Handbook (7^th Edition):

Taleon Alban, Victor Manuel. “Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption.” 2013. Web. 24 Jan 2021.

Vancouver:

Taleon Alban VM. Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption. [Internet] [Doctoral dissertation]. Texas A&M University; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1969.1/151146.

Council of Science Editors:

Taleon Alban VM. Phenolic Compounds of Sorghum, their Chemopreventive Properties and Absorption. [Doctoral Dissertation]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151146

2. Nardella, Flore. Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization.

Degree: Docteur es, Chimie biologique et thérapeutique, 2017, Université de Strasbourg

URL: http://www.theses.fr/2017STRAF018

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Le paludisme est responsable de plus de 438 000 morts en 2015. L’apparition et la propagation de P. falciparum résistants à l’artémisinine, l’antipaludique le plus… (more)

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Le paludisme est responsable de plus de 438 000 morts en 2015. L’apparition et la propagation de P. falciparum résistants à l’artémisinine, l’antipaludique le plus puissant, est un problème majeur en Asie du Sud-Est. Un besoin impérieux de nouveaux médicaments présentant une action rapide et conservée vis-à-vis de ces parasites résistants se fait sentir pour remplacer l’artémisinine. Cette thèse porte sur le développement d’une nouvelle série chimique inspirée d’un biflavonoïde naturel, la lanaroflavone. Le composé tête-de-série MR27770 présente des propriétés intéressantes : il agit de façon plus rapide que l’artémisinine tout au long du cycle érythrocytaire du parasite, ses propriétés pharmacocinétiques sont prometteuses et il est partiellement actif chez la souris impaludée. De plus, il ne présente pas de résistances croisées avec l’artémisinine ou les autres antipaludiques. Son mécanisme d’action n’est pas connu mais pourrait impliquer un stress osmotique. Ce composé prometteur présente néanmoins une activité moyenne in vitro ce qui a motivé l’étude topologique de sa structure et mené à des dérivés optimisés.

Malaria was responsible for 438.000 deaths in 2015. The increasing proportion of P. falciparum parasites resistant to artemisinin, the most potent antimalarial, is a major concern in Southeast Asia. Fast acting drugs with unaltered activity versus the current multi-drug resistant strains are urgently needed to replace artemisinin. This thesis deals with a new antimalarial series based on the structure of an active natural biflavonoid called lanaroflavone. The lead compound, MR27770, displays interesting properties: it acts throughout the blood cycle faster than artemisinin, its pharmacokinetic properties are promising, and it exhibits a partial in vivo antimalarial activity. Plus, it has no cross-resistance with artemisinin or other antimalarials. Its mode of action is unknown and could imply an osmotic stress. This promising compound has however a mild in vitro activity which motivated the topological study of its structure and led to optimized derivatives.

Advisors/Committee Members: Vonthron-Sénécheau, Catherine (thesis director), Candolfi, Ermanno (thesis director).

Subjects/Keywords: Paludisme; Plasmodium; Médicament; Antipaludique; Flavone; Flavonoides; Composé naturel; Pharmacologie; Malaria; Plasmodium; Drug; Antimalarial; Flavone; 615.19

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APA (6^th Edition):

Nardella, F. (2017). Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2017STRAF018

Chicago Manual of Style (16^th Edition):

Nardella, Flore. “Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization.” 2017. Doctoral Dissertation, Université de Strasbourg. Accessed January 24, 2021. http://www.theses.fr/2017STRAF018.

MLA Handbook (7^th Edition):

Nardella, Flore. “Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization.” 2017. Web. 24 Jan 2021.

Vancouver:

Nardella F. Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2017. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2017STRAF018.

Council of Science Editors:

Nardella F. Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament : Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization. [Doctoral Dissertation]. Université de Strasbourg; 2017. Available from: http://www.theses.fr/2017STRAF018

Université Paris-Sud – Paris XI

3. Thevenin, Marion. Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives.

Degree: Docteur es, Chimie, 2013, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2013PA112173

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Les maladies tropicales provoquées par des parasites protozoaires tels que Trypanosoma brucei, Plasmodium falciparum et Leishmania donovani, infectent des milliards d'individus dans le monde et… (more)

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Les maladies tropicales provoquées par des parasites protozoaires tels que Trypanosoma brucei, Plasmodium falciparum et Leishmania donovani, infectent des milliards d'individus dans le monde et en tuent des millions chaque année. Actuellement, les phénomènes de résistance face aux thérapies actuelles utilisées pour traiter ces maladies dites " négligées " deviennent inquiétants et problématiques. Par conséquent, la découverte de nouvelles classes de molécules bioactives antiparasitaires est primordiale.C'est dans ce contexte que s'inscrit ce travail de thèse. La cissampeloflavone est un dimère chalcone-flavone isolé en 2003 d’une plante vénézuélienne, Cissampelos pareira. Cette molécule a démontré une bonne activité contre T. brucei (CI50 = 1 µM). Par ailleurs, des études de modélisation moléculaire ont prédit que son dérivé 4-désoxycissampeloflavone possèderait une bonne affinité pour une enzyme essentielle à la survie du parasite. Pour ces raisons, nous avons entrepris la synthèse totale de ces deux molécules originales jamais réalisée à ce jour.Des analogues simplifiés ont d’abord été synthétisés afin de mettre au point le schéma réactionnel pour former la cissampeloflavone et la 4-désoxycissampeloflavone. Ces composés ont pour base commune le noyau benzofurane qui porte soit la " partie chalcone " soit la " partie flavone " de ces dimères. Les deux synthèses totales ont ensuite été entreprises.Ce travail de thèse a notamment permis la création d'une librairie d'analogues benzofuranes polysubstitués, la découverte d'une réaction de méthylénation originale et la formation de nouveaux dérivés furanoflavones. La plupart ont été évalués sur T. brucei, P. falciparum et L. donovani. Plusieurs d'entre eux ont présenté une activité trypanocide intéressante et prometteuse.

Tropical diseases caused by protozoan parasites such as Trypanosoma brucei, Plasmodium falciparum and Leishmania donovani, infect billions of people worldwide and kill millions of them every year. Nowadays, resistance phenomena against actual therapies used to treat these " neglected " diseases are becoming worring and problematic. Therefore, discovery of new classes of antiparasitic bioactive molecules is primordial.This is the aim of this PhD work. Cissampeloflavone is a chalcone-flavone dimer isolated in 2003 from a Venezuelan plant, Cissampelos pareira. This molecule has showed a good activity against Trypanosoma brucei (IC50 = 1 µM). Besides, molecular docking studies have predicted that its derivative 4-desoxycissampeloflavone would possess a good affinity for an essential enzyme for parasite survival. For these reasons, we undertook the total synthesis of these two original molecules never carried out to date.Simplified analogues have been prepared in order to elaborate a synthetic pathway to form cissampeloflavone and 4-desoxycissampeloflavone. These compounds possess the benzofuran ring as common core which bears either the "chalcone part" or the "flavone part" of these dimers. The total syntheses were then undertaken.This PhD work has…

Advisors/Committee Members: Dubois, Joëlle (thesis director).

Subjects/Keywords: Cissampeloflavone; Benzofurane; Flavone; Chalcone; Antiparasitaire; Méthylène bis; Synthèse totale; Cissampeloflavone; Benzofuran; Flavone; Chalcone; Antiparasitic; Methylene bis; Total synthesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thevenin, M. (2013). Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2013PA112173

Chicago Manual of Style (16^th Edition):

Thevenin, Marion. “Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives.” 2013. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 24, 2021. http://www.theses.fr/2013PA112173.

MLA Handbook (7^th Edition):

Thevenin, Marion. “Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives.” 2013. Web. 24 Jan 2021.

Vancouver:

Thevenin M. Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2013. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2013PA112173.

Council of Science Editors:

Thevenin M. Développement de nouveaux agents antiparasitaires : vers la synthèse totale de la cissampeloflavone et de dérivés : Development of novel antiparasitic agents : towards the total synthesis of cissampeloflavone and derivatives. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2013. Available from: http://www.theses.fr/2013PA112173

East Tennessee State University

4. Whitted, Crystal L. Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones.

Degree: PhD, Biomedical Sciences, 2016, East Tennessee State University

URL: https://dc.etsu.edu/etd/3167

► Flavonoids are polyphenolic secondary metabolites found in plants that have bioactive properties including antiviral, antioxidant, and anticancer. Two isomeric flavone were extracted from Gnaphalium… (more)

▼ Flavonoids are polyphenolic secondary metabolites found in plants that have bioactive properties including antiviral, antioxidant, and anticancer. Two isomeric flavone were extracted from Gnaphalium elegans and Achyrocline bogotensis, plants used by the people from the Andean region of South America as remedies for cancer. 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5, 7–dihydroxy- 3, 6, 8 trimethoxy flavone/ flavone A) and 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3, 5–dihydroxy-6, 7, 8–trimethoxy flavone/ flavone B) have shown antineoplastic activity against colon cancer cell lines dependent upon their differentiation status. Pharmacokinetic studies reported herein were used to determine dosing for antitumor assays, as well as determine target tissue concentration. These included the development of methods to extract the flavones from plasma or colon tissue and reverse phase high performance liquid chromatography methods for quantification. Quantification methods were linear (r²≥ 0.99) with plasma calibration curves ranging from 250 - 2,500 ng/mL and 2,500 - 100,000 ng/mL for both flavones and colon calibration curves ranging from 250 – 100,000 ng/g (flavone A) and 1,000-25,000 ng/g (flavone B). Intravenous administration of a 20 mg/kg dose in rats yielded half-lives of 83.68 ± 56.61 and 107.45 ± 53.31 minutes with clearance values of 12.99 ± 13.78 and 80.79 ± 35.06 mL/min/kg for flavones A and B, respectively. Analysis of colon tissue yielded concentrations of 1639 ± 601 ng/g (flavone A) and 5975 ± 2480 ng/g (flavone B), suggesting both may be good candidate for individual or adjunct therapy for colon cancer due to distribution to the target tissue. Preliminary studies in colon cancer cells CaCo 2 and HCT 116 using either flavone in combination with 5-fluorouracil (5-FU) suggested synergistic activity of these compounds. The combination treatment increased induction of apoptosis by enhancing the DNA damaging mechanism of 5-FU. In vivo, preliminary xenograft experiments using HCT 116 cells showed smaller tumors in mice dosed with flavone B as compared to the 5-FU or combination treatment. Further experiments are warranted to confirm these observations.

Subjects/Keywords: flavone A; flavone B; pharmacokinetics; colon cancer; anticancer; Biology; Cancer Biology; Cell and Developmental Biology; Molecular Biology; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whitted, C. L. (2016). Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones. (Doctoral Dissertation). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/3167

Chicago Manual of Style (16^th Edition):

Whitted, Crystal L. “Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones.” 2016. Doctoral Dissertation, East Tennessee State University. Accessed January 24, 2021. https://dc.etsu.edu/etd/3167.

MLA Handbook (7^th Edition):

Whitted, Crystal L. “Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones.” 2016. Web. 24 Jan 2021.

Vancouver:

Whitted CL. Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones. [Internet] [Doctoral dissertation]. East Tennessee State University; 2016. [cited 2021 Jan 24]. Available from: https://dc.etsu.edu/etd/3167.

Council of Science Editors:

Whitted CL. Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones. [Doctoral Dissertation]. East Tennessee State University; 2016. Available from: https://dc.etsu.edu/etd/3167

NSYSU

5. Li, Liang-You. (ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate.

Degree: Master, Chemistry, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0604113-154532

► ä¸ã 1-ï¼o-Methoxyphenylï¼-3-phenylprop-2-en-1-oneï¼35ï¼ã1-ï¼o- allyloxyphenylï¼-3-phenylprop-2-en-1-oneï¼37ï¼ã3-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-oneï¼38ï¼ã3-ï¼o- allyloxyphenylï¼-3-phenylprop-2-en-1-oneï¼39ï¼ã1-ï¼o-methoxyphenylï¼-3-phenylprop-2-yn-1-oneï¼40ï¼have been studied by means of pyrolysis and photolysis. Under pyrolytic conditions, compounds 35ã37 and 40 gave expected product flavoneï¼36ï¼and major product… (more)

Subjects/Keywords: 2-phenylbenzo[b]furan; flash vacuum pyrolysis; photolysis; stilbene; flavone

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APA (6^th Edition):

Li, L. (2013). (ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0604113-154532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Liang-You. “(ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate.” 2013. Thesis, NSYSU. Accessed January 24, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0604113-154532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Liang-You. “(ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate.” 2013. Web. 24 Jan 2021.

Vancouver:

Li L. (ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Jan 24]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0604113-154532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li L. (ä¸) Pyrolytic and Photolytic Studies of 1-ï¼o-methoxyphenylï¼-3-phenylprop-2-en-1-one and Its Derivatives (äº) Pyrolytic Study of (N-Methyl-2-indolyl)methyl Benzoate. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0604113-154532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Gabriela Lemos de Azevedo Maia. Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.).

Degree: 2011, Universidade Federal da Paraíba

URL: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1788 ; http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1789

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A família Asteraceae é a maior família de angiospermas e representa quase 10% da flora mundial. A família tem sido uma dos mais estudadas, em… (more)

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A família Asteraceae é a maior família de angiospermas e representa quase 10% da flora mundial. A família tem sido uma dos mais estudadas, em grande parte devido aos compostos químicos promissores produzido por este grupo. Visando contribuir para o estudo quimiotaxonômicos da família Asteraceae, Praxelis clematidea e Verbesina macrophylla foram submetidos a um estudo fitoquímico para isolar seus constituintes químicos, através de métodos cromatográficos usuais, e depois para identificá-los por meio de métodos espectroscópicos, tais como RMN de 1H e 13C uni e bidimensionais, além de comparação com dados da literatura. O estudo químico das partes aéreas de V. macrophylla resultou no isolamento de seis compostos (ácido p-cumárico, 6-E-p-cumaroil-4α-hidroxieudesmano, 6-Z-p-cumaroil- 4α-hidroxieudesmano, bornil-p-cis-cumarato, bornil-p-trans-cumarato e ácido phidroxibenzóico). Uma flavona (5,7,3 ,4 -tetrahidroxiflavona) foi isolado do extrato acetato de etila das partes aéreas de P. clematidea e seis flavonas foram isolados a partir de extrato clorofórmico (4,5,7- trihidroxiflavona ; 4,5-dihidroxi-7 metoxiflavona; 5-hidroxi-4,7-dimetoxiflavona; 4,5,7-trimetoxiflavona; 5,4-dihidroxi-6,7 dimetoxiflavona e 4,5,6,7- tetrametoxiflavona), todos os flavonóides estão sendo descritos pela primeira vez na espécie. O flavonas do extrato clorofórmico de P. clematidea foram testadas para a toxicidade contra Staphylococcus aureus SA- 1199B, uma cepa que possuem a bomba de efluxo NorA. O flavonas testadas não mostraram qualquer atividade antibacteriana significativa contra a cepa Staphylococcus aureus usados, mas foram capazes de modular a resistência bacteriana à drogas. Esta propriedade pode estar relacionado com o grau de lipofilicidade do flavonas conferidos pelos grupos metoxila, já que a 4, 5,6,7 tetramethoxyflavone o composto mais metoxilados, reduziu a concentração inibitória mínima do fármaco (Norfloxacina) 16 vezes.

The family Asteraceae is the largest angiosperm family and represents nearly 10% of the world s total flora. The family has been one of the most studied, in large part due to the promising chemical compounds produced by this group. Aiming at contributing to the chemotaxonomic study of the family Asteraceae , Praxelis clematidea e Verbesina macrophylla were submitted to a phytochemical study to isolate its chemical constituents, through usual chromatographic methods, and after identifying them by means of spectroscopic methods such as 1H and 13C NMR, with the add of two-dimensional techniques, besides comparison with literature data. Chemical study of the aerial parts of V. macrophylla resulted in the isolation of six compounds (p-coumaric acid, 6-E-p-cumaroil-4α-hydroxieudesmane, 6-Z-p-cumaroil- 4α-hydroxieudesmane, bornil-p-cis-cumarate, bornil-p-trans- coumarate and phydroxybenzoic acid). One flavone (5,7,3 ,4 -tetrahydroxyflavone) was isolated from ethyl acetate extract of the aerial parts of P. clematidea and six flavones were isolated from chloroform extract (4,5,7- trihydroxyflavone;…

Advisors/Committee Members: José Maria Barbosa Filho, Luis Cezar Rodrigues.

Subjects/Keywords: FARMACOLOGIA; Monoterpeno; Sesquiterpeno; Verbesina macrophylla; Flavona; Praxelis clematidea; Sesquiterpen; Monoterpen; Flavone; Verbesina macrophylla; Praxelis clematidea

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maia, G. L. d. A. (2011). Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.). (Thesis). Universidade Federal da Paraíba. Retrieved from http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1788 ; http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maia, Gabriela Lemos de Azevedo. “Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.).” 2011. Thesis, Universidade Federal da Paraíba. Accessed January 24, 2021. http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1788 ; http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maia, Gabriela Lemos de Azevedo. “Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.).” 2011. Web. 24 Jan 2021.

Vancouver:

Maia GLdA. Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.). [Internet] [Thesis]. Universidade Federal da Paraíba; 2011. [cited 2021 Jan 24]. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1788 ; http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maia GLdA. Contribuição ao conhecimento químico de espécies da família Asteraceae (Verbesina macrophylla (Cass.) S.F. Blake e Praxelis clematidea R.M. King &Robinson.). [Thesis]. Universidade Federal da Paraíba; 2011. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1788 ; http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Martin Benlloch, Xavier. Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale.

Degree: Docteur es, Chimie, 2015, Université de Strasbourg

URL: http://www.theses.fr/2015STRAF002

►

Le travail de recherche présenté dans ce mémoire de thèse a été centré sur une nouvelle famille de flavones aux propriétés antivirales. Mon travail de… (more)

▼

Le travail de recherche présenté dans ce mémoire de thèse a été centré sur une nouvelle famille de flavones aux propriétés antivirales. Mon travail de thèse avait pour premier objectif d'améliorer la synthèse de la ladanéine (tête de série) et permettre l'accès à d’autres analogues. Un développement méthodologique a permis de mettre au point une synthèse compatible avec les procédés industriels qui permette d'améliorer les rendements et de raccourcir significativement les délais d'obtention. De plus, aucune purification par colonne de silice n’est nécessaire. Une étude physico-chimique détaillée a ensuite été menée. Les propriétés acido-basiques de la série de composés ont d'abord été évaluées avant l'étude des propriétés électrochimiques. Ces données sont déterminantes pour une meilleure compréhension du mécanisme d'action de ces flavones. La complexation au Fe(III) a été également démontrée comme essentielle pour l’activité antivirale de ces composés. Les propriétés de complexation de ce cation ont donc été étudiées et ont apporté des informations importantes. Finalement, dans le but d’améliorer les propriétés pharmacocinétiques de ces agents virucides, des formulations originales avec le Mg(II), cation biocompatible, ont été élaborées et étudiées.

The research work presented in this manuscript was centered on a novel flavone series displaying potent antiviral activities toward enveloped viruses such as HCV. The first goal of my research work was to improve the synthesis of ladanein (the lead antiviral compound) and to allow an easy access to a broad range of analogues. A methodological approach allowed setting up a synthetic route compatible with industrial processes with high yields and significantly shortened preparation time. Furthermore, no silica gel column chromatography was needed throughout the synthetic route. A thorough physico-chemical study was then undertaken. The acido-basic properties of this homogenous series of compounds were first evaluated prior to the investigation of their electrochemical parameters. These data are essential for a deeper understanding of the mechanism of action of these polyphenolic compounds. Fe(III) was shown to be essential for the antiviral activity of these compounds and, hence, the Fe(III) complexation properties of the flavones have been studied and provided important information. Last but not least, in order to improve the pharmacokinetic properties of the flavones, original formulation approaches using the biocompatible Mg(II) cation were undertaken and thoroughly investigated.

Advisors/Committee Members: Davioud-Charvet, Élisabeth (thesis director), Elhabiri, Mourad (thesis director).

Subjects/Keywords: Flavone; Ladanéine; Virus de l'hépatite C; Activité antivirale; Nhibiteurs d'entrée des virions; Coordination; Physico-chimie; Electrochimie; Synthèse totale; Formulation; Flavone; Ladanein; HCV; Antiviral activity; Entry inhibitors of virions; Coordination; Physico-chemistry; Electrochemistry; Total Synthesis; Formulation; 547.2; 579.2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martin Benlloch, X. (2015). Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2015STRAF002

Chicago Manual of Style (16^th Edition):

Martin Benlloch, Xavier. “Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale.” 2015. Doctoral Dissertation, Université de Strasbourg. Accessed January 24, 2021. http://www.theses.fr/2015STRAF002.

MLA Handbook (7^th Edition):

Martin Benlloch, Xavier. “Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale.” 2015. Web. 24 Jan 2021.

Vancouver:

Martin Benlloch X. Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2015. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2015STRAF002.

Council of Science Editors:

Martin Benlloch X. Synthesis and physico-chemical study of a novel flavone antiviral lead : Synthèse et étude physico-chimique d'une nouvelle tête de série flavonoïde antivirale. [Doctoral Dissertation]. Université de Strasbourg; 2015. Available from: http://www.theses.fr/2015STRAF002

8. Souza Junior, Jaime de. Determinação da estrutura cristalina e molecular de uma flavona.

Degree: Mestrado, Ciência e Engenharia de Materiais, 1996, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-162112/ ;

►

Neste trabalho apresenta-se inicialmente algumas considerações sobre a difração de raios-X, suas principais leis, fatores de correção dos dados experimentais, uma revisão sobre os principais… (more)

▼

Neste trabalho apresenta-se inicialmente algumas considerações sobre a difração de raios-X, suas principais leis, fatores de correção dos dados experimentais, uma revisão sobre os principais Métodos Diretos de resolução da estrutura, e considerações sobre o refinamento da estrutura obtida. A seguir descreve-se a determinação da estrutura cristalina do produto natural 5,4\'-Dihidroxi-3\', 5-́dimetoxi- 6,7 -(2\",2-̈dimetilpirano) flavona de fórmula molecular C22H20O<sub<7, isolado de plantas da espécie Neoraputia paraensis, que cristaliza-se no sistema monoclínico, grupo espacial C2/c, com os seguintes parâmetros de cela unitária: a = 13,651(1), b= 23,428(2),c= 13,725(1) Å β= 119,528(4)°, V=3819,6(5)A⓷ , Dc = 1,366g cm-3 e Z =8 moléculas por cela unitária. A estrutura foi resolvida através da aplicação de Métodos Diretos. Os índices de discordância finais são: R= 0,0509, Rw = 0,0530 para 1743 reflexões com I ≥ 3σ(I) e Ra11=0,157. A estrutura foi refinada fazendo uso dos cálculos de Fourier Diferença e pelo método de mínimos quadrados usando matriz completa. A molécula apresenta duas ligações de hidrogênio intramoleculares, de força média (distâncias O-O 2,558(3) e 2,674(4) β). O empacotamento cristalino apresenta duas outras ligações de hidrogênio intermoleculares, mais fracas, sendo feitas com as moléculas geradas pelo espelho c (distâncias O-O 2,830(3) e 2,992(3) β). O efeito destas ligações intermoleculares é o da formação de cadeias ao longo da direção [101].

Initially, some considerations about X-ray diffraction, its laws, the factors for the correction of experimental data, a revision of the main Direct Methods for structure resolution, and comments on the refinement of the resulting structure are presented. Next, the structure determination of the compound 5,4-́dihydroxy-3\'-5\'- dimethoxy-6,7(2\",2\́')dimethylpyran)flavone is described The compound is isolated from plants of the species Neuroputia paraenesis and has the molecular formula C22H20O<sub<7. It crystallizes in the monoclinic system, space group C2/c, with the following unit cell parameters: a = 13.651(1), b= 23.428(2), c= 13.725(1) Å β= 119,528(4)°, V=3819,6(5)A⓷ , Dc = 1,366g cm-3 e Z =8molecules per unit cell. The structure was solved applying Direct Methods. The final disagreement indices are: R= 0.0509, Rw= 0.0530 for 1743 reflections with ≥ 3σ(I) and Ra11=0,157. The structure was refined applying Fourier difference calculations and full matrix least squares methods. The molecule shows two intramolecular hydrogen bonds of medium strength (distances O-O 2.558(3) and 2.674(4) β). The crystal packing shows also two weaker hydrogen bonds; these are formed between the molecules generated by the c mirror (distances O-O 2.830(3) and 2.992(3) β). The result of these intermolecular hydrogen bonds is the formation of chains in [10 1] direction.

Advisors/Committee Members: Santos, Regina Helena de Almeida.

Subjects/Keywords: Direct methods; Flavona; Flavone; Métodos diretos; Raios-x; X-ray

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APA (6^th Edition):

Souza Junior, J. d. (1996). Determinação da estrutura cristalina e molecular de uma flavona. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-162112/ ;

Chicago Manual of Style (16^th Edition):

Souza Junior, Jaime de. “Determinação da estrutura cristalina e molecular de uma flavona.” 1996. Masters Thesis, University of São Paulo. Accessed January 24, 2021. http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-162112/ ;.

MLA Handbook (7^th Edition):

Souza Junior, Jaime de. “Determinação da estrutura cristalina e molecular de uma flavona.” 1996. Web. 24 Jan 2021.

Vancouver:

Souza Junior Jd. Determinação da estrutura cristalina e molecular de uma flavona. [Internet] [Masters thesis]. University of São Paulo; 1996. [cited 2021 Jan 24]. Available from: http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-162112/ ;.

Council of Science Editors:

Souza Junior Jd. Determinação da estrutura cristalina e molecular de uma flavona. [Masters Thesis]. University of São Paulo; 1996. Available from: http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-162112/ ;

Virginia Commonwealth University

9. Verghese, Jenson. Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development.

Degree: PhD, Pharmaceutical Sciences, 2014, Virginia Commonwealth University

URL: https://doi.org/10.25772/RNMP-WE82 ; https://scholarscompass.vcu.edu/etd/611

► The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research.… (more)

▼ The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets that is quickly rendering our current arsenal of drugs ineffective for these therapies. Unless new drugs with novel mechanisms of action are identified and developed at a faster pace, we face a losing battle in managing these diseases. The first part of this work concerns with the natural product Simocyclinone D8 (SD8). Simocyclinone D8 is an angucyclinone antibiotic that inhibits DNA gyrase with a novel mechanism of action that has been termed competitive inhibition. Simocyclinone D8 was found to inhibit the growth of both Gram-(+ve) and Gram-(–ve) organisms and also inhibit a fluoroquinolone resistant mutant of DNA gyrase. Inspired by the structure and novel mechanism of action that SD8 displays, we synthesized analogues based on the co-crystal structure of SD8 with DNA gyrase. These compounds were found to inhibit DNA gyrase, albeit by a different mechanism of action than that of SD8. We also conducted studies towards the total chemical synthesis of SD8 and made three out of the four fragments in SD8 in decent yields. The second part of this work is focused on the development of a substrate-competitive covalent inhibitor for protein kinase B (AKT). AKT is a valid target for cancer research with two compounds currently in late stage clinical trials. Developing substrate- competitive inhibitors for kinases is a novel approach in targeting them, with very few examples in the literature. This mechanism has been postulated to overcome common resistance mutations that cancer targets harbor. A major drawback in this approach is the low binding affinity for peptide substrates by kinases. We circumvented this problem of affinity by utilizing a covalent mode of binding and synthesized a potent non-peptide active-site directed irreversible compound that inhibits AKT. Further studies on this compound are underway and are expected to yield a compound that can be used as a therapeutic agent or as a probe for AKT. Advisors/Committee Members: Keith Ellis.

Subjects/Keywords: Simocyclinone D8; SD8; Anti-Bacterial agents; Flavone; Total Synthesis; AKT; Protein Kinase B; chloromethyl ketone; kinases; substrate competitive; coumarin; aniline; phenylalanine; electrophiles.; Medicine and Health Sciences; Pharmacy and Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Verghese, J. (2014). Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/RNMP-WE82 ; https://scholarscompass.vcu.edu/etd/611

Chicago Manual of Style (16^th Edition):

Verghese, Jenson. “Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development.” 2014. Doctoral Dissertation, Virginia Commonwealth University. Accessed January 24, 2021. https://doi.org/10.25772/RNMP-WE82 ; https://scholarscompass.vcu.edu/etd/611.

MLA Handbook (7^th Edition):

Verghese, Jenson. “Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development.” 2014. Web. 24 Jan 2021.

Vancouver:

Verghese J. Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2014. [cited 2021 Jan 24]. Available from: https://doi.org/10.25772/RNMP-WE82 ; https://scholarscompass.vcu.edu/etd/611.

Council of Science Editors:

Verghese J. Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development. [Doctoral Dissertation]. Virginia Commonwealth University; 2014. Available from: https://doi.org/10.25772/RNMP-WE82 ; https://scholarscompass.vcu.edu/etd/611

University of Kansas

10. Leighty, Matthew. Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis.

Degree: PhD, Medicinal Chemistry, 2009, University of Kansas

URL: http://hdl.handle.net/1808/5466

► The first total synthesis of boehmeriasin A was achieved in seven steps from readily available materials with an overall yield of 29%. The absolute stereochemistry… (more)

Subjects/Keywords: Organic chemistry; Boehmeriasin a; Flavone; Natural product synthesis; Vinylogous amide; Vinylogous ester

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leighty, M. (2009). Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/5466

Chicago Manual of Style (16^th Edition):

Leighty, Matthew. “Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis.” 2009. Doctoral Dissertation, University of Kansas. Accessed January 24, 2021. http://hdl.handle.net/1808/5466.

MLA Handbook (7^th Edition):

Leighty, Matthew. “Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis.” 2009. Web. 24 Jan 2021.

Vancouver:

Leighty M. Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis. [Internet] [Doctoral dissertation]. University of Kansas; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1808/5466.

Council of Science Editors:

Leighty M. Vinylogous Esters and Amides: Useful Synthons for Diversity-Oriented and Natural Product Synthesis. [Doctoral Dissertation]. University of Kansas; 2009. Available from: http://hdl.handle.net/1808/5466

University of Gothenburg / Göteborgs Universitet

11. Dahlén, Kristian 1973-. Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions.

Degree: 2006, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/16980

Subjects/Keywords: chromone; flavone; scaffold; Pd-catalyzed chemistry; Stille; Heck; Sonogashira; Suzuki; Mannich reaction; peptidomimetics; beta-turn; fluorescence

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APA (6^th Edition):

Dahlén, K. 1. (2006). Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/16980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dahlén, Kristian 1973-. “Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions.” 2006. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 24, 2021. http://hdl.handle.net/2077/16980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dahlén, Kristian 1973-. “Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions.” 2006. Web. 24 Jan 2021.

Vancouver:

Dahlén K1. Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2006. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2077/16980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dahlén K1. Design and Synthesis of 2,3,6,8- Tetrasubstituted Chromone Derivatives by Pd-catalyzed Coupling Reactions. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2006. Available from: http://hdl.handle.net/2077/16980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Tennessee State University

12. Dean, Jennifer Dawn. Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.

Degree: MS, Biomedical Sciences, 2003, East Tennessee State University

URL: https://dc.etsu.edu/etd/849

► Dietary flavonoids are ubiquitous and are marketed as supplements. Characterized as antioxidants, they offer protection against a number of degenerative diseases. Flavonoid mechanics involve… (more)

Subjects/Keywords: quercetin; antioxidant; oxidative DNA damage; rutin; flavonoids; flavone; Medical Sciences; Medicine and Health Sciences

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APA (6^th Edition):

Dean, J. D. (2003). Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage. (Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dean, Jennifer Dawn. “Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.” 2003. Thesis, East Tennessee State University. Accessed January 24, 2021. https://dc.etsu.edu/etd/849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dean, Jennifer Dawn. “Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.” 2003. Web. 24 Jan 2021.

Vancouver:

Dean JD. Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage. [Internet] [Thesis]. East Tennessee State University; 2003. [cited 2021 Jan 24]. Available from: https://dc.etsu.edu/etd/849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dean JD. Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage. [Thesis]. East Tennessee State University; 2003. Available from: https://dc.etsu.edu/etd/849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

ETH Zürich

13. Geissberger, Heinz. Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure.

Degree: 1939, ETH Zürich

URL: http://hdl.handle.net/20.500.11850/133572

Subjects/Keywords: XANTHONE + FLAVONE (NATÜRLICHE FARBSTOFFE); XANTHONES + FLAVONES (NATURAL DYES); info:eu-repo/classification/ddc/540; Chemistry

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APA (6^th Edition):

Geissberger, H. (1939). Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure. (Doctoral Dissertation). ETH Zürich. Retrieved from http://hdl.handle.net/20.500.11850/133572

Chicago Manual of Style (16^th Edition):

Geissberger, Heinz. “Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure.” 1939. Doctoral Dissertation, ETH Zürich. Accessed January 24, 2021. http://hdl.handle.net/20.500.11850/133572.

MLA Handbook (7^th Edition):

Geissberger, Heinz. “Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure.” 1939. Web. 24 Jan 2021.

Vancouver:

Geissberger H. Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure. [Internet] [Doctoral dissertation]. ETH Zürich; 1939. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/20.500.11850/133572.

Council of Science Editors:

Geissberger H. Ueber Farbstoffe der Xanthonreihe, hergestellt aus 1,4,5,8-Naphthalintetracarbonsäure. [Doctoral Dissertation]. ETH Zürich; 1939. Available from: http://hdl.handle.net/20.500.11850/133572

University of Kansas

14. Amolins, Michael Wayne. Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery.

Degree: MS, Medicinal Chemistry, 2009, University of Kansas

URL: http://hdl.handle.net/1808/5582

► This thesis represents a discussion of the advancements made in the area of Hsp90 therapeutics, and the development of a novel Hsp90 inhibitory scaffold of… (more)

Subjects/Keywords: Pharmaceutical chemistry; Chemistry; Biochemistry; Organic chemistry; Cancer; Flavone; Heat shock proteins; Molecular modeling; Naphthoquinone; Neuroprotection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amolins, M. W. (2009). Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/5582

Chicago Manual of Style (16^th Edition):

Amolins, Michael Wayne. “Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery.” 2009. Masters Thesis, University of Kansas. Accessed January 24, 2021. http://hdl.handle.net/1808/5582.

MLA Handbook (7^th Edition):

Amolins, Michael Wayne. “Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery.” 2009. Web. 24 Jan 2021.

Vancouver:

Amolins MW. Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery. [Internet] [Masters thesis]. University of Kansas; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1808/5582.

Council of Science Editors:

Amolins MW. Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery. [Masters Thesis]. University of Kansas; 2009. Available from: http://hdl.handle.net/1808/5582

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Open Access Theses and Dissertations