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You searched for subject:(Fibrinopeptide A ). Showing records 1 – 3 of 3 total matches.

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1. Laura Cristina Lima Diniz. Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae).

Degree: 2016, University of São Paulo

Em Triatoma infestans ainda não há pesquisas de isolamento de Peptídeos Antimicrobianas e como têm contato muitos microrganismos acreditamos que eles produzem esses componentes antimicrobianos. Neste estudo identificamos quatro peptídeos antimicrobianos principais. Os Tin-TK-I e Tin-TK-II que são similares com Taquicininas de insetos, não são hemolíticos e ativos contra três bactérias e três fungos, e são capazes de lisar membranas. Tin-TK-I é degradado por aminopeptidases e tem estrutura randômica. Tin-TK-II é degradado por carboxipeptidases e tem estrutura de hélice 310. A Triastina que é similar a uma proteína cuticular de T. infestans, é ativa contra duas bactérias e três fungos, não hemolítica, forma uma hélice 310, lisa membranas, e sofre ação de carboxi e aminopeptidases. E o Triatogênio que é similar ao fibrinopeptideo-A humano, e possui um análogo. É ativo contra três bactérias e seis fungos, e seu análogo contra três bactérias e três fungos. Não são hemolíticos, formam poros em membranas, formam alfa-hélices e são degradados por aminopeptidases.

Regarding new researches with Antimicrobial Peptides in triatomines, none have been developed with T. infestans, and due to its survival in a highly infectious habitat, we believe that it products antimicrobial molecules. On this study, four main AMPs have been identified. Tin-TK-I and II that were similar to Tachykinin-like proteins from insects, they were not hemolytic, and were active against three bacteria and three fungi on the antimicrobial assay. Tin-TK-I presents a random structure and was degraded by aminopeptidases, as Tin-TK-II presents a helix 310 structure and was affected by carboxipeptidases. Both of them can disrupt negatively charged membranes. Triastin that was similar to a cuticular protein from T. infestans, was active against two bacteria and three fungi, had no hemolytic activity, presents a helix 310 structure and can disrupt negatively charged membranes. Triatogen was similar to the human fibrinopeptide A, and it has an analogue. Triatogen was active against three bacteria and six fungi, and its analogue was active against three bacteria and three fungi. They were not active against human erythrocytes, both were degraded by aminopeptidases. They can generate pores on membranes and both have alfa-helix structure.

Advisors/Committee Members: Pedro Ismael da Silva Junior, Edison Luiz Durigon, Ursula Castro de Oliveira, Karin do Amaral Riske.

Subjects/Keywords: Triatoma infestans; Fibrinopeptídeo A; Peptídeos antimicrobianos; Tachykinin-like; Triastina; Triatoma infestans; Antimicrobial peptides; Fibrinopeptide A; Infestin; Tachykinin-like molecules

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Diniz, L. C. L. (2016). Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae). (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/87/87131/tde-17012017-150239/

Chicago Manual of Style (16th Edition):

Diniz, Laura Cristina Lima. “Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae).” 2016. Masters Thesis, University of São Paulo. Accessed April 13, 2021. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-17012017-150239/.

MLA Handbook (7th Edition):

Diniz, Laura Cristina Lima. “Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae).” 2016. Web. 13 Apr 2021.

Vancouver:

Diniz LCL. Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae). [Internet] [Masters thesis]. University of São Paulo; 2016. [cited 2021 Apr 13]. Available from: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-17012017-150239/.

Council of Science Editors:

Diniz LCL. Identificação e caracterização de peptídeos antimicrobianos da hemolinfa de Triatoma infestans (Hemiptera: Reduviidae). [Masters Thesis]. University of São Paulo; 2016. Available from: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-17012017-150239/


University of Illinois – Urbana-Champaign

2. Maki, Agatha. Analyzing peptide release using mass spectrometry.

Degree: PhD, 0323, 2014, University of Illinois – Urbana-Champaign

Neuropeptides are cell-to-cell signaling molecules that act as neurotransmitters, neuromodulators and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While many peptides can be detected in a tissue homogenate, these will include processing intermediates and even protein degradation products. It is of great interest in the field of peptidomics to focus on functional characterization of proteins products such as cell-to-cell signaling peptides that are released from specific neuronal tissues, whether a brain region or specific cell. A variety of analytical techniques have emerged over the years to analyze neuropeptide release, and these methods have enabled scientists to characterize thousands of brain peptides. The focus of this research was on using various sampling approaches coupled to matrix-assisted laser desorption/ionization-mass spectrometry (MALDI MS) to analyze neuropeptide release from rodent brains. Chapter 2 is a general overview of the current state of analytical methods used to characterize neuropeptide release from cells to animals. Chapter 3 highlights two methods demonstrating neuropeptide release in a mouse model of fragile X syndrome. Sampling techniques using synaptoneurosomes and ex vivo brain slices were used to show a neuropeptide release deficit in Fmr1 KO mice. Chapter 4 highlights an approach utilizing in vivo microdialysis coupled to offline MALDI MS. This method was used to characterize extracellular peptide release from the hippocampus of rats in response to saline or morphine injection coupled with a spontaneous alternation task. In particular, fibrinopeptide A, a peptide derived from the fibrinogen α-chain, was significantly upregulated in rats exposed to morphine and spontaneous alternation testing. The functional consequence of fibronopeptide A release is still under investigation. The advancement of such analytical approaches to characterize neuropeptide release from a variety of samples ranging from cells to animals enables new discovery efforts for understanding the physiological and behavioral role of unknown peptides. Advisors/Committee Members: Sweedler, Jonathan V. (advisor), Sweedler, Jonathan V. (Committee Chair), Gillette, Martha U. (committee member), Ceman, Stephanie S. (committee member), Galvez, Roberto (committee member).

Subjects/Keywords: Peptides; Neuropeptides; Peptide Release; Mass Spectrometry; Fragile X Syndrome; Synaptoneurosomes; Brain Slices; Rab3A; Dense-Core Vesicles; Morphine; In Vivo Microdialysis; Hippocampus; Fibrinogen; Fibrinogen-α Chain Peptides; Fibrinopeptide A.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Maki, A. (2014). Analyzing peptide release using mass spectrometry. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/49662

Chicago Manual of Style (16th Edition):

Maki, Agatha. “Analyzing peptide release using mass spectrometry.” 2014. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed April 13, 2021. http://hdl.handle.net/2142/49662.

MLA Handbook (7th Edition):

Maki, Agatha. “Analyzing peptide release using mass spectrometry.” 2014. Web. 13 Apr 2021.

Vancouver:

Maki A. Analyzing peptide release using mass spectrometry. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2014. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2142/49662.

Council of Science Editors:

Maki A. Analyzing peptide release using mass spectrometry. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2014. Available from: http://hdl.handle.net/2142/49662


Queensland University of Technology

3. Rowland, Denise Phi-Phoung. Evaluation of soluble fibrin as an early marker of thrombosis.

Degree: 1997, Queensland University of Technology

Subjects/Keywords: Fibrin Testing; Thrombosis Diagnosis; Enzyme-linked immunosorbent assay; soluble fibrin; enzyme immunoassay; agglutination test; fibrinopeptide A; D dimer; deep vein thrombosis; pulmonary embolism; myocardial infarction; unstable angina; lung cancer; thesis; doctoral

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rowland, D. P. (1997). Evaluation of soluble fibrin as an early marker of thrombosis. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/36956/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rowland, Denise Phi-Phoung. “Evaluation of soluble fibrin as an early marker of thrombosis.” 1997. Thesis, Queensland University of Technology. Accessed April 13, 2021. http://eprints.qut.edu.au/36956/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rowland, Denise Phi-Phoung. “Evaluation of soluble fibrin as an early marker of thrombosis.” 1997. Web. 13 Apr 2021.

Vancouver:

Rowland DP. Evaluation of soluble fibrin as an early marker of thrombosis. [Internet] [Thesis]. Queensland University of Technology; 1997. [cited 2021 Apr 13]. Available from: http://eprints.qut.edu.au/36956/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rowland DP. Evaluation of soluble fibrin as an early marker of thrombosis. [Thesis]. Queensland University of Technology; 1997. Available from: http://eprints.qut.edu.au/36956/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.