subject:(Fetus)

University of Manchester

1. Sibley, Colin. The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation.

Degree: Thesis (D.Sc.), 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-nutrient-exchange-phenotype-of-the-placenta-in-fetalgrowth-restriction-characterization-adaptation-and-regulation(35a27da9-ad7c-4e7e-8e91-8742304a5c9c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588114

► An essential function of the placenta is the exchange of nutrients, and wasteproducts of fetal metabolism, between mother and fetus. The placenta thereforeplays a key… (more)

▼ An essential function of the placenta is the exchange of nutrients, and wasteproducts of fetal metabolism, between mother and fetus. The placenta thereforeplays a key role in determining fetal growth and size at birth. Fetal growthrestriction (FGR) is a complication affecting around 5% of pregnancies. Thereare several possible causes of FGR but the most common in the Western world isplacental dysfunction. The FGR baby is at much greater risk of stillbirth andneurodevelopmental morbidities than the normally grown baby. Furthermore, thesmaller baby per se has an increased risk of a range of morbidities as an adult.The thrust of the work covered in this thesis was to improve understanding of theabnormalities in placental exchange physiology associated with FGR. The goalwas (and is) to develop new placental diagnostic biomarkers for the disease andnew treatments based on improving placental function.The first tranche of work described showed that there are specific changes intransporter activities in the placenta in FGR. My colleagues and I showed thatSystem A amino acid transporter activity in the microvillous plasma membrane(MVM) of the syncytiotrophoblast (transporting epithelium of the placenta) isreduced, per mg membrane protein, and that this reduction is related to theseverity of the disease. This contrasted with our observation in normal pregnancythat MVM System A activity, per mg protein, is inversely related to size of the babyat birth, and first suggested the concept of placental adaptation to fetal growthdemand. We, and others, went on to show that a number of other transporters inthe syncytiotrophoblast are altered in FGR. However, not all transporters areaffected and at least one is upregulated. This led me to hypothesise that some ofthese changes are causal to FGR and some are responses, or adaptations, toabnormal fetal growth. The direct causes of transporter activity changes are notknown but our work, and that of others, suggests that glucocorticoids play a role.We also showed that transporter activities in the placenta are affected in othercomplications where fetal growth is aberrant. Furthermore, we provided evidencethat denuded areas of the syncytiotrophoblast might be the morphologicalcorrelate of a route of passive transfer of hydrophilic solutes across the placenta.Our studies in a mouse model of FGR suggest that abnormalities in such aparacellular route may be part of the placental dysfunction in the disease.In the final group of publications of this thesis I describe work showing gestationalchanges in placental transporter activities. I suggest that these are primarilyregulated to maintain fetal growth trajectory, but may also provide for specificnutrient demands at particular times in gestation. This explanation was supportedby work with genetically modified mice showing experimentally that placentaltransporter activity is regulated, or adapted, in relation to fetal growth demand. Itappears from several studies described here that there is a matching of fetalgrowth demand and placental nutrient…

Subjects/Keywords: 612.6; Placenta; Fetus

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APA (6^th Edition):

Sibley, C. (2013). The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-nutrient-exchange-phenotype-of-the-placenta-in-fetalgrowth-restriction-characterization-adaptation-and-regulation(35a27da9-ad7c-4e7e-8e91-8742304a5c9c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588114

Chicago Manual of Style (16^th Edition):

Sibley, Colin. “The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-nutrient-exchange-phenotype-of-the-placenta-in-fetalgrowth-restriction-characterization-adaptation-and-regulation(35a27da9-ad7c-4e7e-8e91-8742304a5c9c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588114.

MLA Handbook (7^th Edition):

Sibley, Colin. “The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation.” 2013. Web. 17 Jan 2021.

Vancouver:

Sibley C. The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 17]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-nutrient-exchange-phenotype-of-the-placenta-in-fetalgrowth-restriction-characterization-adaptation-and-regulation(35a27da9-ad7c-4e7e-8e91-8742304a5c9c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588114.

Council of Science Editors:

Sibley C. The nutrient exchange phenotype of the placenta in fetal growth restriction : characterization, adaptation and regulation. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-nutrient-exchange-phenotype-of-the-placenta-in-fetalgrowth-restriction-characterization-adaptation-and-regulation(35a27da9-ad7c-4e7e-8e91-8742304a5c9c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588114

Texas A&M University

2. Halloran, Katherine Marie. Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit.

Degree: MS, Physiology of Reproduction, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/174048

► In a previous study, administration of progesterone (P4) to ewes during the first 9 to 12 days of pregnancy has been shown to accelerate blastocyst… (more)

▼ In a previous study, administration of progesterone (P4) to ewes during the first 9 to 12 days of pregnancy has been shown to accelerate blastocyst development by Day 12 of pregnancy, likely due to P4-induced upregulation of key genes in uterine epithelia responsible for secretion of histotroph. This study determined if exogenous P4-induced acceleration of blastocyst development during the peri-implantation period affects fetal-placental development on Day 125 of pregnancy. Suffolk ewes (n=40) were mated to fertile rams and assigned randomly to receive daily intramuscular injections of either corn oil vehicle (CO, n=20) or 25 mg progesterone in CO (P4, n =20). After breeding (Day 0), treatments began on Day 1.5 and continued through Day 8 of pregnancy. Ewes from each treatment group were hysterectomized on Day 125 of pregnancy. After separating the endometrium from the chorioallantois, sections of placentomes, caruncles, cotyledons, and endometrium were processed to assess expression of mRNAs and proteins. Plasma from maternal and fetal blood was analyzed for concentrations of P4 by RIA. Samples of allantoic and amniotic fluid were obtained for analysis of glucose, fructose, amino acids, and polyamines. Volumes of the fetal fluids were measured. Fetal parameters recorded included weight, crown-rump length, abdominal and chest circumferences, and sex. Placental measurements included weight, length, and number of placentomes. There was no difference in fetal growth nor placental growth due to treatment; however, placentae of single pregnancies were longer (P<0.0001) and had more placentomes (P<0.0001) than those in twin pregnancies. qPCR analysis showed differential expression of genes between P4 and CO treated ewes in endometrium and placentomes. Low-affinity cationic amino acid transporter SLC7A2 mRNA increased (P=0.0022) in endometria of P4 treated ewes, while VEGFA and TUB were increased (P=0.0242) and decreased (P= 0.0089), respectively, in single pregnancies. In placentomes, expression of SLC2A5 and SLC2A8 mRNAs increased (P=0.0024) and (P=0.0005), respectively, in P4 treated ewes. Expression of both ACTB and TUB mRNAs increased (P=0.0019) and (P<0.0001), respectively, in placentomes of P4 treated ewes. SDHA and GAPDH were used as control genes. There was significantly more fructose than glucose in placental fluids (P > 0.05). Advisors/Committee Members: Bazer, Fuller W (advisor), Wu, Guoyao (advisor), Johnson, Gregory A (committee member), Dunlap, Kathrin A (committee member).

Subjects/Keywords: ovine; placenta; fetus; histotroph; progesterone

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APA (6^th Edition):

Halloran, K. M. (2018). Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174048

Chicago Manual of Style (16^th Edition):

Halloran, Katherine Marie. “Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit.” 2018. Masters Thesis, Texas A&M University. Accessed January 17, 2021. http://hdl.handle.net/1969.1/174048.

MLA Handbook (7^th Edition):

Halloran, Katherine Marie. “Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit.” 2018. Web. 17 Jan 2021.

Vancouver:

Halloran KM. Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1969.1/174048.

Council of Science Editors:

Halloran KM. Effects of Progesterone Supplementation on Growth and Development of the Fetal-Placental Unit. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/174048

Montana State University

3. May, Lewis K. The microaerophilic nature of Vibrio Fetus.

Degree: MS, College of Agriculture, 1953, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/5715

Subjects/Keywords: Campylobacter fetus.

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APA (6^th Edition):

May, L. K. (1953). The microaerophilic nature of Vibrio Fetus. (Masters Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/5715

Chicago Manual of Style (16^th Edition):

May, Lewis K. “The microaerophilic nature of Vibrio Fetus.” 1953. Masters Thesis, Montana State University. Accessed January 17, 2021. https://scholarworks.montana.edu/xmlui/handle/1/5715.

MLA Handbook (7^th Edition):

May, Lewis K. “The microaerophilic nature of Vibrio Fetus.” 1953. Web. 17 Jan 2021.

Vancouver:

May LK. The microaerophilic nature of Vibrio Fetus. [Internet] [Masters thesis]. Montana State University; 1953. [cited 2021 Jan 17]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/5715.

Council of Science Editors:

May LK. The microaerophilic nature of Vibrio Fetus. [Masters Thesis]. Montana State University; 1953. Available from: https://scholarworks.montana.edu/xmlui/handle/1/5715

Montana State University

4. Alexander, James Kermott. The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus.

Degree: MS, College of Agriculture, 1954, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/4737

Subjects/Keywords: Campylobacter fetus.

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APA (6^th Edition):

Alexander, J. K. (1954). The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus. (Masters Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/4737

Chicago Manual of Style (16^th Edition):

Alexander, James Kermott. “The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus.” 1954. Masters Thesis, Montana State University. Accessed January 17, 2021. https://scholarworks.montana.edu/xmlui/handle/1/4737.

MLA Handbook (7^th Edition):

Alexander, James Kermott. “The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus.” 1954. Web. 17 Jan 2021.

Vancouver:

Alexander JK. The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus. [Internet] [Masters thesis]. Montana State University; 1954. [cited 2021 Jan 17]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4737.

Council of Science Editors:

Alexander JK. The utilization of carbohydrate intermediates and amino acids by Vibrio Fetus. [Masters Thesis]. Montana State University; 1954. Available from: https://scholarworks.montana.edu/xmlui/handle/1/4737

University of Sydney

5. Walsh, Anna. The Legal Status of Prenatal Life in Australia .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/14310

► This thesis is a doctrinal analysis of the legislation and case law in Australia regulating destruction of the fetus in the contexts of third party… (more)

Subjects/Keywords: fetus; abortion; conscientious objection

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APA (6^th Edition):

Walsh, A. (2015). The Legal Status of Prenatal Life in Australia . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14310

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Walsh, Anna. “The Legal Status of Prenatal Life in Australia .” 2015. Thesis, University of Sydney. Accessed January 17, 2021. http://hdl.handle.net/2123/14310.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Walsh, Anna. “The Legal Status of Prenatal Life in Australia .” 2015. Web. 17 Jan 2021.

Vancouver:

Walsh A. The Legal Status of Prenatal Life in Australia . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2123/14310.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Walsh A. The Legal Status of Prenatal Life in Australia . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/14310

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

6. Sprague, James I., Jr. Growth and development of the swine fetus.

Degree: PhD, 1961, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:37603

Subjects/Keywords: Swine; Fetus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sprague, James I., J. (1961). Growth and development of the swine fetus. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:37603

Chicago Manual of Style (16^th Edition):

Sprague, James I., Jr. “Growth and development of the swine fetus.” 1961. Doctoral Dissertation, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:37603.

MLA Handbook (7^th Edition):

Sprague, James I., Jr. “Growth and development of the swine fetus.” 1961. Web. 17 Jan 2021.

Vancouver:

Sprague, James I. J. Growth and development of the swine fetus. [Internet] [Doctoral dissertation]. Michigan State University; 1961. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:37603.

Council of Science Editors:

Sprague, James I. J. Growth and development of the swine fetus. [Doctoral Dissertation]. Michigan State University; 1961. Available from: http://etd.lib.msu.edu/islandora/object/etd:37603

Universidade Federal de Santa Maria

7. Ana Cláudia Mello Groff. PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA.

Degree: 2005, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1473

►

A campilobacteriose genital bovina, caracterizada principalmente por infertilidade, é uma doença de difícil diagnóstico, devido à natureza microaerófila do seu agente etiológico, o Campylobacter fetus,… (more)

▼

A campilobacteriose genital bovina, caracterizada principalmente por infertilidade, é uma doença de difícil diagnóstico, devido à natureza microaerófila do seu agente etiológico, o Campylobacter fetus, tendo assim sua prevalência subestimada. Este trabalho teve por objetivo avaliar a utilização da técnica de PCR para o diagnóstico da campilobacteriose genital bovina, utilizando amostras de aspirado prepucial, muco cervical e conteúdo abomasal de fetos abortados, coletadas em meio de transporte e enriquecimento; bem como comparar seu desempenho com a técnica do isolamento bacteriano. Foram testados cinco diferentes protocolos de extração de DNA de Campylobacter fetus: termo extração, lise com proteinase K, lise com isotiocianato de guanidina, lise com DNAzol? e lise com brometo de cetiltrimetilamônio (CTAB). Também foram avaliadas a especificidade, a sensibilidade e a aplicação da técnica da PCR em amostras clínicas. Os resultados indicaram que o CTAB foi o protocolo de extração mais eficiente; o par de primers utilizado mostrou-se específico; e o limite de detecção foi 63 unidades formadoras de colônias (UFC) de C. fetus. A PCR encontrou 24% (68/277) das amostras clínicas positivas para C. fetus, enquanto a cultura encontrou 2,8% (8/277). A técnica da PCR é específica e sensível, e mostra-se superior a cultura no diagnóstico da campilobacteriose genital bovina.

Bovine genital campylobacteriosis is a disease of difficult diagnostic because of the microaerophilic nature of its etiologic agent, Campylobacter fetus, thereby causing the prevalence related to this disease to be underestimated. The purpose of this study was to evaluate the utilization of PCR for the diagnosis of genital campylobacteriosis, using samples obtained from bull prepuce aspirate, cow cervical mucus, and abomasum contents obtained from aborted fetuses, collected in transport and enrichment medium. Five different DNA extraction protocols were tested: thermal extraction, lyses with proteinase K, lyses with guanidine isothiocyanate, lyses with DNAzol? , and lyses with CTAB. The specificity, sensitivity and technical application of PCR assay were also evaluated with clinical samples. The PCR performance was compared to the culture technique for bacterial isolation. The CTAB was the most efficient extraction protocol; the pair of primers used was shown to be specific; and the limit of detection was of 63 CFU of Campylobacter fetus. PCR demonstrated that 24% (68/277) of the clinical samples were positive for Campylobacter fetus, while only 2.8% (8/277) of samples were positive by culture techinque. These results indicate that the PCR technique is specific and sensitivy, and is superior to the culture for the diagnosis of bovine genital campylobacteriosis.

Advisors/Committee Members: Rudi Weiblen, Agueda Palmira Castagna de Vargas.

Subjects/Keywords: diagnóstico; campylobacter fetus; isolamento; MEDICINA VETERINARIA; campylobacter fetus; diagnostic; culture

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Groff, A. C. M. (2005). PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Groff, Ana Cláudia Mello. “PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA.” 2005. Thesis, Universidade Federal de Santa Maria. Accessed January 17, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Groff, Ana Cláudia Mello. “PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA.” 2005. Web. 17 Jan 2021.

Vancouver:

Groff ACM. PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2005. [cited 2021 Jan 17]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Groff ACM. PCR PARA O DIAGNÓSTICO DA CAMPILOBACTERIOSE GENITAL BOVINA. [Thesis]. Universidade Federal de Santa Maria; 2005. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Sibley, Colin. The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation.

Degree: 2013, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:205138

► An essential function of the placenta is the exchange of nutrients, and wasteproducts of fetal metabolism, between mother and fetus. The placenta thereforeplays a key… (more)

▼ An essential function of the placenta is the exchange of nutrients, and wasteproducts of fetal metabolism, between mother and fetus. The placenta thereforeplays a key role in determining fetal growth and size at birth. Fetal growthrestriction (FGR) is a complication affecting around 5% of pregnancies. Thereare several possible causes of FGR but the most common in the Western world isplacental dysfunction. The FGR baby is at much greater risk of stillbirth andneurodevelopmental morbidities than the normally grown baby. Furthermore, thesmaller baby per se has an increased risk of a range of morbidities as an adult.The thrust of the work covered in this thesis was to improve understanding of theabnormalities in placental exchange physiology associated with FGR. The goalwas (and is) to develop new placental diagnostic biomarkers for the disease andnew treatments based on improving placental function.The first tranche of work described showed that there are specific changes intransporter activities in the placenta in FGR. My colleagues and I showed thatSystem A amino acid transporter activity in the microvillous plasma membrane(MVM) of the syncytiotrophoblast (transporting epithelium of the placenta) isreduced, per mg membrane protein, and that this reduction is related to theseverity of the disease. This contrasted with our observation in normal pregnancythat MVM System A activity, per mg protein, is inversely related to size of the babyat birth, and first suggested the concept of placental adaptation to fetal growthdemand. We, and others, went on to show that a number of other transporters inthe syncytiotrophoblast are altered in FGR. However, not all transporters areaffected and at least one is upregulated. This led me to hypothesise that some ofthese changes are causal to FGR and some are responses, or adaptations, toabnormal fetal growth. The direct causes of transporter activity changes are notknown but our work, and that of others, suggests that glucocorticoids play a role.We also showed that transporter activities in the placenta are affected in othercomplications where fetal growth is aberrant. Furthermore, we provided evidencethat denuded areas of the syncytiotrophoblast might be the morphologicalcorrelate of a route of passive transfer of hydrophilic solutes across the placenta.Our studies in a mouse model of FGR suggest that abnormalities in such aparacellular route may be part of the placental dysfunction in the disease.In the final group of publications of this thesis I describe work showing gestationalchanges in placental transporter activities. I suggest that these are primarilyregulated to maintain fetal growth trajectory, but may also provide for specificnutrient demands at particular times in gestation. This explanation was supportedby work with genetically modified mice showing experimentally that placentaltransporter activity is regulated, or adapted, in relation to fetal growth demand. Itappears from several studies described here that there is a matching of fetalgrowth demand and placental nutrient… Advisors/Committee Members: Aplin, John.

Subjects/Keywords: Placenta; Fetus

…own right. Abnormal fetal growth may be defined as the failure of a fetus to reach its… …during early pregnancy, improving blood flow to the fast growing placenta and fetus (… …the interactions between fetus and placenta and, most recently, exploration of methods by… …the greater will be its ability to transport nutrient to the fetus. However, this seemed… …the time) to keep the total number of transporters per placenta and per fetus constant…

13 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sibley, C. (2013). The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:205138

Chicago Manual of Style (16^th Edition):

Sibley, Colin. “The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:205138.

MLA Handbook (7^th Edition):

Sibley, Colin. “The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation.” 2013. Web. 17 Jan 2021.

Vancouver:

Sibley C. The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 17]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:205138.

Council of Science Editors:

Sibley C. The Nutrient Exchange Phenotype of the Placenta in FetalGrowth Restriction: Characterization, Adaptation and Regulation. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:205138

University of Oxford

9. Fore, Ian Michael. The distribution of cardiac output in the fetus.

Degree: PhD, 1982, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:f9a0ac22-2baf-408f-83e5-9eedb5809014 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.345430

Subjects/Keywords: 612; Fetus : Hypertension

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fore, I. M. (1982). The distribution of cardiac output in the fetus. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:f9a0ac22-2baf-408f-83e5-9eedb5809014 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.345430

Chicago Manual of Style (16^th Edition):

Fore, Ian Michael. “The distribution of cardiac output in the fetus.” 1982. Doctoral Dissertation, University of Oxford. Accessed January 17, 2021. http://ora.ox.ac.uk/objects/uuid:f9a0ac22-2baf-408f-83e5-9eedb5809014 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.345430.

MLA Handbook (7^th Edition):

Fore, Ian Michael. “The distribution of cardiac output in the fetus.” 1982. Web. 17 Jan 2021.

Vancouver:

Fore IM. The distribution of cardiac output in the fetus. [Internet] [Doctoral dissertation]. University of Oxford; 1982. [cited 2021 Jan 17]. Available from: http://ora.ox.ac.uk/objects/uuid:f9a0ac22-2baf-408f-83e5-9eedb5809014 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.345430.

Council of Science Editors:

Fore IM. The distribution of cardiac output in the fetus. [Doctoral Dissertation]. University of Oxford; 1982. Available from: http://ora.ox.ac.uk/objects/uuid:f9a0ac22-2baf-408f-83e5-9eedb5809014 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.345430

Uppsala University

10. Lindgren, Karin. Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige.

Degree: Women's and Children's Health, 2012, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175737

► The purpose of this study was to investigate women's experiences of pain, bleeding,to discover the fetus, hospitalization associated with medical abortion at home and… (more)

Subjects/Keywords: Medical abortion; Home; Misoprostol; Bleeding; Pain; Fetus.

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APA (6^th Edition):

Lindgren, K. (2012). Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175737

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lindgren, Karin. “Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige.” 2012. Thesis, Uppsala University. Accessed January 17, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175737.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lindgren, Karin. “Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige.” 2012. Web. 17 Jan 2021.

Vancouver:

Lindgren K. Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige. [Internet] [Thesis]. Uppsala University; 2012. [cited 2021 Jan 17]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175737.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lindgren K. Kvinnors upplevelser av smärta och blödning samt möjlighet att upptäcka fostret i samband med hemabort : En enkätstudie vid två kliniker i Sverige. [Thesis]. Uppsala University; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175737

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

11. Karlsson, Kirsten, 1931-. Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions.

Degree: 1974, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/12192

Subjects/Keywords: Asphyxia; Fetus: physiology

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APA (6^th Edition):

Karlsson, Kirsten, 1. (1974). Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/12192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karlsson, Kirsten, 1931-. “Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions.” 1974. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 17, 2021. http://hdl.handle.net/2077/12192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karlsson, Kirsten, 1931-. “Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions.” 1974. Web. 17 Jan 2021.

Vancouver:

Karlsson, Kirsten 1. Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1974. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2077/12192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karlsson, Kirsten 1. Intrauterine asphyxia : an experimental study in rabbits and sheep with special reference to uterine blood flow and fetal cerebral reactions. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1974. Available from: http://hdl.handle.net/2077/12192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Yunusova, Roza. Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep.

Degree: 2012, North Dakota State University

URL: http://hdl.handle.net/10365/26539

► The placenta and fetal intestines are two key nutrient transport organs that sustain and nurture growing fetus. Insufficient placental development and consequently inadequate fetal nutrient… (more)

Subjects/Keywords: Mothers – Nutrition.; Fetus – Nutrition.; Intestines.; Sheep.; Placenta.

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APA (6^th Edition):

Yunusova, R. (2012). Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep. (Thesis). North Dakota State University. Retrieved from http://hdl.handle.net/10365/26539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yunusova, Roza. “Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep.” 2012. Thesis, North Dakota State University. Accessed January 17, 2021. http://hdl.handle.net/10365/26539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yunusova, Roza. “Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep.” 2012. Web. 17 Jan 2021.

Vancouver:

Yunusova R. Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep. [Internet] [Thesis]. North Dakota State University; 2012. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10365/26539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yunusova R. Effects of Maternal Nutrition, Intrauterine Growth Restriction (IUGR), and Estrogen (E2) Supplementation on Placental and Fetal Intestinal Growth and Development in Sheep. [Thesis]. North Dakota State University; 2012. Available from: http://hdl.handle.net/10365/26539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

13. Stephens, Margaret. The effects of maternal stress on offspring behavior.

Degree: MS, Psychology, 1969, Georgia Tech

URL: http://hdl.handle.net/1853/28734

Subjects/Keywords: Fetus; Prenatal influences

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APA (6^th Edition):

Stephens, M. (1969). The effects of maternal stress on offspring behavior. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/28734

Chicago Manual of Style (16^th Edition):

Stephens, Margaret. “The effects of maternal stress on offspring behavior.” 1969. Masters Thesis, Georgia Tech. Accessed January 17, 2021. http://hdl.handle.net/1853/28734.

MLA Handbook (7^th Edition):

Stephens, Margaret. “The effects of maternal stress on offspring behavior.” 1969. Web. 17 Jan 2021.

Vancouver:

Stephens M. The effects of maternal stress on offspring behavior. [Internet] [Masters thesis]. Georgia Tech; 1969. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1853/28734.

Council of Science Editors:

Stephens M. The effects of maternal stress on offspring behavior. [Masters Thesis]. Georgia Tech; 1969. Available from: http://hdl.handle.net/1853/28734

University of Sydney

14. Eviston, David. Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/18414

► Pre-eclampsia is a systemic disorder unique to human pregnancy and a leading cause of maternal-fetal morbidity and mortality worldwide. While its exact aetiology remains unknown,… (more)

▼ Pre-eclampsia is a systemic disorder unique to human pregnancy and a leading cause of maternal-fetal morbidity and mortality worldwide. While its exact aetiology remains unknown, maternal immune changes in pre-eclampsia, including reduced regulatory T cells (Treg), support a breakdown in maternal-fetal immune tolerance. The current immune theory for pre-eclampsia is likely to be incomplete, however, as fetal immune function is not considered. Although obvious restrictions limit access to the human fetus, the thymus, a primary immune organ, can be readily observed by ultrasound at mid-gestation. Fetal thymus changes observed via ultrasound can therefore offer non-invasive insight into fetal immunity. Beyond its immediate consequences to maternal-fetal wellbeing, pre-eclampsia has been linked to childhood allergy. This suggests fetal programming of allergic disease, a concept also supported by studies linking newborn head size with allergy. A possible explanation for this link centres on altered neurotrophin levels, including BDNF. Neurotrophins are important mediators of brain growth and development, which are also dysregulated in allergic disease. Cord blood BDNF levels are also altered in pre-eclampsia. We therefore hypothesized that pre-eclampsia would be associated with altered fetal head growth. This thesis consists of five publications. Firstly, Chapters 3 and 4, observed a smaller fetal thymus in pre- eclampsia, with a smaller fetal thymus preceding clinical disease. The third study, Chapter 5, included a large prospective study which confirmed the findings of Chapter 4. Chapter 5 also included thymus histopathology, which revealed dramatic apoptosis of thymocytes in pre-eclampsia, especially affecting Treg cells. Adding to our theory of neurotrophin dysregulation as a possible factor in fetal programming, Chapter 6 demonstrated increased fetal head growth in pre-eclampsia. Finally, Chapter 7 found reduced fetal head size at mid-gestation to be associated with childhood allergy. In summary, this research has shown fetal thymus changes to precede clinical disease in pre-eclampsia, possibly reflecting an active role for fetal immunity in disease pathogenesis. Our findings also support the developmental programming of allergic disease.

Subjects/Keywords: fetus; thymus; ultrasound; pre-eclampsia; allergy; developmental

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APA (6^th Edition):

Eviston, D. (2018). Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Eviston, David. “Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease .” 2018. Thesis, University of Sydney. Accessed January 17, 2021. http://hdl.handle.net/2123/18414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Eviston, David. “Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease .” 2018. Web. 17 Jan 2021.

Vancouver:

Eviston D. Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2123/18414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Eviston D. Fetal Thymus Changes in Pre-eclampsia and the Developmental Origins of Allergic Disease . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/18414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

15. Saeki, EIko, 1979-. Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan.

Degree: PhD, Sociology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/55675/

►

This dissertation examines the competing notions of personhood in the late Tokugawa era in Japan (from the mid-eighteenth to the late nineteenth centuries), by investigating… (more)

Subjects/Keywords: Fetus – Moral and ethical aspects – Japan

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APA (6^th Edition):

Saeki, EIko, 1. (2017). Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/55675/

Chicago Manual of Style (16^th Edition):

Saeki, EIko, 1979-. “Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan.” 2017. Doctoral Dissertation, Rutgers University. Accessed January 17, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/55675/.

MLA Handbook (7^th Edition):

Saeki, EIko, 1979-. “Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan.” 2017. Web. 17 Jan 2021.

Vancouver:

Saeki, EIko 1. Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Jan 17]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55675/.

Council of Science Editors:

Saeki, EIko 1. Contested boundaries of personhood: the moral status of the fetus and infant in late Tokugawa Japan. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55675/

Michigan State University

16. Fowler, Edward Herbert. The developmental histology of the integument of fetal pigs.

Degree: MS, 1962, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:9667

Subjects/Keywords: Skin; Swine; Fetus

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APA (6^th Edition):

Fowler, E. H. (1962). The developmental histology of the integument of fetal pigs. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:9667

Chicago Manual of Style (16^th Edition):

Fowler, Edward Herbert. “The developmental histology of the integument of fetal pigs.” 1962. Masters Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:9667.

MLA Handbook (7^th Edition):

Fowler, Edward Herbert. “The developmental histology of the integument of fetal pigs.” 1962. Web. 17 Jan 2021.

Vancouver:

Fowler EH. The developmental histology of the integument of fetal pigs. [Internet] [Masters thesis]. Michigan State University; 1962. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:9667.

Council of Science Editors:

Fowler EH. The developmental histology of the integument of fetal pigs. [Masters Thesis]. Michigan State University; 1962. Available from: http://etd.lib.msu.edu/islandora/object/etd:9667

University of Melbourne

17. Glanville, Elsa Jane. The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/210742

► Reducing reproductive wastage is important for the Australian sheep industry. Campylobacter fetus fetus and C. jejuni infections in ewes contribute to reproductive wastage through abortions,… (more)

▼ Reducing reproductive wastage is important for the Australian sheep industry. Campylobacter fetus fetus and C. jejuni infections in ewes contribute to reproductive wastage through abortions, stillbirths and the birth of small, weak neonates, potentially at greater risk of starvation-mismothering-exposure (SME). A combined vaccine against C. fetus fetus and C. jejuni (Ovilis Campyvax®, MSD Animal Health) is registered in Australia to reduce reproductive wastage due to Campylobacter, but few independent field trials of the vaccine have been conducted in commercial flocks. This study described the effects of Ovilis Campyvax® on maiden ewe reproduction in a randomised controlled field trial on four winter-/spring-lambing Victorian sheep farms. Conception and lamb marking rates were compared amongst nineteen-month-old Merino and Merino-cross ewes randomly allocated to vaccination or control groups at mating on each farm (each n = 211–249/group). Ewes were grazed together from mating until immediately before lambing, when they were set-stocked in treatment groups in matched paddocks. Antibody titres to Campylobacter spp. were measured at mating, mid-gestation pregnancy diagnosis and lamb marking in a subset of ewes. A cross-sectional study of cause of neonatal lamb mortality was also conducted on each farm during lambing. Vaccination had no effect on ewe conception rate (67% to 117% depending on farm). Two of four farms had serological evidence of prior exposure to C. fetus fetus, and variable exposure to this organism occurred during gestation on all farms. Campylobacter jejuni titres were high on all farms at mating, but decreased thereafter. Despite serological evidence of a good response to C. fetus fetus vaccination on all farms, vaccination did not significantly increase lamb marking rates (63% to 100%, depending on farm). The main causes of lamb mortality were dystocia, starvation-mismothering-exposure and predation. There was a suggestion of a difference in the pattern of causes of neonatal lamb mortality between vaccinated and control ewes. The difference was not statistically significant, but corresponded with anecdotal observations made by the flock owners. Additional large scale studies into vaccination and the causes of neonatal lamb mortality are needed to further investigate these observations. Vaccination appeared to prevent Campylobacter-associated neonatal lamb mortality and morbidity on the farm with the greatest exposure to C. fetus fetus. On that farm, 55% of unvaccinated ewes that failed to rear a lamb had ‘high’ (≥ 1:80) C. fetus fetus titres, compared to 0% of ewes that successfully reared a lamb. Additionally, C. fetus fetus was only recovered from necropsied lambs born to unvaccinated ewes. The results demonstrate that ewes can be vaccinated with Ovilis Campyvax® during mating without impacting conception rates. However, the effect of Campylobacter vaccination on reproductive output is complex and multifactorial. Vaccination effects may be obscured by other causes of reproductive…

Subjects/Keywords: ovine campylobacteriosis; Campylobacter fetus fetus; Campylobacter jejuni; sheep; reproductive wastage; abortion; campyvax(R) vaccination

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APA (6^th Edition):

Glanville, E. J. (2017). The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/210742

Chicago Manual of Style (16^th Edition):

Glanville, Elsa Jane. “The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria.” 2017. Masters Thesis, University of Melbourne. Accessed January 17, 2021. http://hdl.handle.net/11343/210742.

MLA Handbook (7^th Edition):

Glanville, Elsa Jane. “The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria.” 2017. Web. 17 Jan 2021.

Vancouver:

Glanville EJ. The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria. [Internet] [Masters thesis]. University of Melbourne; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11343/210742.

Council of Science Editors:

Glanville EJ. The effect of vaccination against Campylobacter on maiden ewe reproduction in Victoria. [Masters Thesis]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/210742

18. Illa Armengol, Míriam. Brain effects of fetal growth restriction and their prevention in an animal model.

Degree: 2017, Universitat de Barcelona

URL: http://hdl.handle.net/10803/565667

► BACKGROUND: Chronic hypoxia due to placental insufficiency and prenatal undernutrition are probably the two major causes worldwide of an adverse intrauterine environment having an impact… (more)

▼ BACKGROUND: Chronic hypoxia due to placental insufficiency and prenatal undernutrition are probably the two major causes worldwide of an adverse intrauterine environment having an impact on neurodevelopment. Clinically, both situations manifest as an intrauterine growth restriction (IUGR), a situation defined as a significant reduction in fetal growth resulting in a birth weight below the 10th percentile. This situation is a well-recognized cause of neurobehavioral and cognitive impairments extending beyond childhood and early adulthood period. Although all these evidence, the structural ground of these functional impairments and the pathophysiological mechanisms are not fully characterized. An improvement in these two aspects would allow us to propose different therapeutic strategies aiming to ameliorate and even revert the long-lasting consequences of the IUGR. HYPOTHESIS: We hypothesized that IUGR produces subtle structural brain changes that underlie the long-term neurobehavioral and cognitive impairments. The severity of the neurodevelopmental consequences might be related to the severity of the prenatal insult (reduction in nutrients with or without a reduction in oxygen). High-resolution brain imaging along with specific histological techniques focused on neuronal connectivity could evidence these structural brain changes. Additionally, we hypothesized that an early postnatal stimulation might ameliorate the structural and functional impairments that persist at the long-term period after IUGR. METHODS: Two animal models of IUGR were used in this thesis: i. A cohort of pregnant rabbits was randomized to reproduce an undernutrition model based on maternal food reduction intake, ii. Another cohort of pregnant rabbits was randomized to the placental insufficiency model based on the surgical ligation of 40-50% of the uteroplacental vessels that irrigate each gestational sac. After the delivery in both models, IUGR and controls animals were followed up to the 70th postnatal days. At the 30th postnatal days, a subgroup of IUGR animals was randomized to an environmental enrichment strategy. In all the groups at the neonatal period, general motor skills, reflexes, and olfactory sensitivity were evaluated. Similarly, at the 70th postnatal days, anxiety, memory, and learning were evaluated. Afterward, animals were sacrificed and brains were fixed and diffusion MRI was then performed. In a subset of animals, changes at the microstructural level and differences in the number of fibers in two specific brain circuits (anxiety and memory circuits) were performed by using a Voxel-Based approach (VBA) and Tractography analysis, respectively. Moreover, brain networks were obtained and evaluated by means of a Connectomics. Finally, a subgroup of animals was also histologically evaluated by means of dendritic spine and perineural nets evaluation in the Hippocampus. RESULTS: IUGR animals showed poorer functional performance in both moments, especially in the model of placental insufficiency. At the long-term… Advisors/Committee Members: Universitat de Barcelona. Facultat de Medicina, [email protected] (authoremail), false (authoremailshow), Gratacós Solsona, Eduard (director), Figueras Retuerta, Francesc (director), true (authorsendemail).

Subjects/Keywords: Fetus; Feto; Neurobiologia del desenvolupament; Neurobiología del desarrollo; Developmental neurobiology; Malalties del fetus; Enfermedades fetales; Fetus diseases; Histologia; Histología; Histology; Ciències de la Salut; 618

10 more images…

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APA (6^th Edition):

Illa Armengol, M. (2017). Brain effects of fetal growth restriction and their prevention in an animal model. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/565667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Illa Armengol, Míriam. “Brain effects of fetal growth restriction and their prevention in an animal model.” 2017. Thesis, Universitat de Barcelona. Accessed January 17, 2021. http://hdl.handle.net/10803/565667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Illa Armengol, Míriam. “Brain effects of fetal growth restriction and their prevention in an animal model.” 2017. Web. 17 Jan 2021.

Vancouver:

Illa Armengol M. Brain effects of fetal growth restriction and their prevention in an animal model. [Internet] [Thesis]. Universitat de Barcelona; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10803/565667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Illa Armengol M. Brain effects of fetal growth restriction and their prevention in an animal model. [Thesis]. Universitat de Barcelona; 2017. Available from: http://hdl.handle.net/10803/565667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

19. 張嘉碧. The use of volumetry by three-dimensional ultrasound in the first trimester.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/57007

Subjects/Keywords: Volume (Cubic content); Fetus - Ultrasonic imaging.; Fetus - Abnormalities.

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APA (6^th Edition):

張嘉碧.. (2009). The use of volumetry by three-dimensional ultrasound in the first trimester. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/57007

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

張嘉碧.. “The use of volumetry by three-dimensional ultrasound in the first trimester.” 2009. Thesis, University of Hong Kong. Accessed January 17, 2021. http://hdl.handle.net/10722/57007.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

張嘉碧.. “The use of volumetry by three-dimensional ultrasound in the first trimester.” 2009. Web. 17 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

張嘉碧.. The use of volumetry by three-dimensional ultrasound in the first trimester. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10722/57007.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

張嘉碧.. The use of volumetry by three-dimensional ultrasound in the first trimester. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/57007

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

20. Lam, Yung-hang. Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy.

Degree: 2001, University of Hong Kong

URL: http://hdl.handle.net/10722/27883

Subjects/Keywords: Thalassemia.; Fetus - Ultrasonic imaging.; Fetus - Diseases - Diagnosis.; Pregnancy - Complications.

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APA (6^th Edition):

Lam, Y. (2001). Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/27883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lam, Yung-hang. “Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy.” 2001. Thesis, University of Hong Kong. Accessed January 17, 2021. http://hdl.handle.net/10722/27883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lam, Yung-hang. “Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy.” 2001. Web. 17 Jan 2021.

Vancouver:

Lam Y. Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy. [Internet] [Thesis]. University of Hong Kong; 2001. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10722/27883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lam Y. Sonographic features of fetuses with homozygous [alpha]-thalassaemia-1during early pregnancy. [Thesis]. University of Hong Kong; 2001. Available from: http://hdl.handle.net/10722/27883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

21. Comas Rovira, Montserrat. Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction.

Degree: Departament d'Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física, 2011, Universitat de Barcelona

URL: http://hdl.handle.net/10803/51517

► SUMMARY 1) Background Fetal growth restriction (FGR) is present in 5-10% of the pregnancies and is associated to high perinatal and long-term cardiovascular morbidity. Subclinical… (more)

Subjects/Keywords: Medicina prenatal; Prenatal Medicine; Malalties del fetus; Enfermedades fetales; Fetus – Diseases; Ciències de la Salut; 618

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Comas Rovira, M. (2011). Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/51517

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Comas Rovira, Montserrat. “Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction.” 2011. Thesis, Universitat de Barcelona. Accessed January 17, 2021. http://hdl.handle.net/10803/51517.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Comas Rovira, Montserrat. “Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction.” 2011. Web. 17 Jan 2021.

Vancouver:

Comas Rovira M. Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction. [Internet] [Thesis]. Universitat de Barcelona; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10803/51517.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Comas Rovira M. Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction. [Thesis]. Universitat de Barcelona; 2011. Available from: http://hdl.handle.net/10803/51517

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Shipp, Darlene. Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment .

Degree: 1992, Drake U

URL: http://hdl.handle.net/2092/539

► The purpose of the study was to examine the effects of perceived fetal movement and/or viewing of the fetus by the pregnant woman via ultrasonography… (more)

Subjects/Keywords: Fetus – Movements; Fetus – Ultrasonic imaging; Attachment behavior

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APA (6^th Edition):

Shipp, D. (1992). Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment . (Thesis). Drake U. Retrieved from http://hdl.handle.net/2092/539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shipp, Darlene. “Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment .” 1992. Thesis, Drake U. Accessed January 17, 2021. http://hdl.handle.net/2092/539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shipp, Darlene. “Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment .” 1992. Web. 17 Jan 2021.

Vancouver:

Shipp D. Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment . [Internet] [Thesis]. Drake U; 1992. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2092/539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shipp D. Effects of Perceived Fetal Movement and Fetal Ultrasound Imagery on Maternal-Fetal Attachment . [Thesis]. Drake U; 1992. Available from: http://hdl.handle.net/2092/539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

23. Kirkpatrick, James R., 1983-. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.

Degree: 2009, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/9679

► My dissertation examines two issues related to disruption of fetal growth: exposure to exogenous estrogenic chemicals and altered nutrition. My first set of studies was… (more)

Subjects/Keywords: Fetus – Growth; Fetus – Nutrition; Estrogen – Toxicology; Mice – Pregnancy

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APA (6^th Edition):

Kirkpatrick, James R., 1. (2009). Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/9679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kirkpatrick, James R., 1983-. “Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.” 2009. Thesis, University of Missouri – Columbia. Accessed January 17, 2021. https://doi.org/10.32469/10355/9679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kirkpatrick, James R., 1983-. “Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.” 2009. Web. 17 Jan 2021.

Vancouver:

Kirkpatrick, James R. 1. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. [Internet] [Thesis]. University of Missouri – Columbia; 2009. [cited 2021 Jan 17]. Available from: https://doi.org/10.32469/10355/9679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kirkpatrick, James R. 1. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. [Thesis]. University of Missouri – Columbia; 2009. Available from: https://doi.org/10.32469/10355/9679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

24. Kirkpatrick, James R., 1983-. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.

Degree: 2009, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/9679

► My dissertation examines two issues related to disruption of fetal growth: exposure to exogenous estrogenic chemicals and altered nutrition. My first set of studies was… (more)

Subjects/Keywords: Fetus – Growth; Fetus – Nutrition; Estrogen – Toxicology; Mice – Pregnancy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kirkpatrick, James R., 1. (2009). Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/9679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kirkpatrick, James R., 1983-. “Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.” 2009. Thesis, University of Missouri – Columbia. Accessed January 17, 2021. http://hdl.handle.net/10355/9679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kirkpatrick, James R., 1983-. “Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus.” 2009. Web. 17 Jan 2021.

Vancouver:

Kirkpatrick, James R. 1. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. [Internet] [Thesis]. University of Missouri – Columbia; 2009. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10355/9679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kirkpatrick, James R. 1. Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus. [Thesis]. University of Missouri – Columbia; 2009. Available from: http://hdl.handle.net/10355/9679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

25. Löbbert, Thorsten. Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero.

Degree: 2003, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-7839

► Problem: Lubeluzole hat sich in tierexperimentellen Modellen als neuroprotektiv erwiesen. Lubeluzole könnte asphyktische Feten vor einem Hirnschaden bewahren, wenn es keine nachteiligen Effekte auf die… (more)

Subjects/Keywords: Neuroprotektivum; Hypoxie; Hirnschädigung; Fetus; Neugeborenes

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APA (6^th Edition):

Löbbert, T. (2003). Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-7839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Löbbert, Thorsten. “Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero.” 2003. Thesis, Ruhr Universität Bochum. Accessed January 17, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-7839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Löbbert, Thorsten. “Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero.” 2003. Web. 17 Jan 2021.

Vancouver:

Löbbert T. Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero. [Internet] [Thesis]. Ruhr Universität Bochum; 2003. [cited 2021 Jan 17]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-7839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Löbbert T. Der Einfluß von Lubeluzole auf die fetale Kreislaufzentralisation unter Asphyxie : eine Untersuchung an geburtsreifen Schaffeten in utero. [Thesis]. Ruhr Universität Bochum; 2003. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-7839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mississippi State University

26. Greene, Jonathan Michael. Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium.

Degree: PhD, Veterinary Medicine, College of, 2013, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03052013-162917/ ;

► L-arginine is one of the most versatile amino acids due to the fact that it serves as a precursor for many molecules which have… (more)

▼ L-arginine is one of the most versatile amino acids due to the fact that it serves as a precursor for many molecules which have important roles in bodily functions including mammalian reproduction. The current studies sought to further examine the role that L-arginine has in mammalian reproduction utilizing both <i>in vivo</i> and <i>in vitro</i> approaches. In the first study, a novel bioluminescent murine pregnancy model was developed to monitor VEGFR2 transcription activity non-invasively in the fetoplacental unit. Secondly, the effect that dietary L-arginine supplementation has during mouse gestation was examined. L-arginine supplementation increased weight gain during the latter third of gestation, total litter size, number of implantation sites, and litter birth weight. Additionally, L-arginine supplementation increased VEGFR2 transcription activity in the fetoplacental unit which may create a more favorable environment for fetal survival. Moreover, the increased number of implantation sites observed suggests an effect of L-arginine at the level of the endometrium. To this end, the effect that L-arginine has on apoptosis and cell proliferation in an established endometrial cell line was examined. The addition of L-arginine at physiological (200 micromolar) and supra-physiological (800 micromolar) concentrations increased cell proliferation , and this effect was achieved through biosynthesis of polyamines and nitric oxide. L-arginine also decreased the proportion of cells that were experiencing mitochondrial mediated apoptosis, and it was observed that this decrease in mitochondrial mediated apoptosis was concurrent with increased phosphorylation of BAD protein, which induces apoptosis when not phosphorylated. The final study examined the ability of porcine uterine epithelial (PUE) cells to synthesize L-arginine from L-citrulline. L-citrulline was able to support PUE cell proliferation in the absence of L-arginine. Additionally, ASS-1 and ASL, L-arginine synthesizing enzymes, were expressed in PUE cells and were regulated by the presence of L-arginine and L-citrulline, respectively. This data would support the hypothesis that PUE cells may be able to convert L-citrulline to L-arginine. Together, the current findings along with the plethora of relevant literature provide further evidence for the role of L-arginine in mammalian reproduction and allow for new questions to be investigated regarding this particular amino acids role in mammalian reproduction. Advisors/Committee Members: Peter L. Ryan (chair), Jean M. N. Feugang (committee member), Brian J. Rude (committee member), Keun Seok Seo (committee member), Scott T. Willard (committee member).

Subjects/Keywords: L-arginine; fetus; placenta; uterus; endometrium; bioluminescence imaging

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APA (6^th Edition):

Greene, J. M. (2013). Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-03052013-162917/ ;

Chicago Manual of Style (16^th Edition):

Greene, Jonathan Michael. “Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium.” 2013. Doctoral Dissertation, Mississippi State University. Accessed January 17, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-03052013-162917/ ;.

MLA Handbook (7^th Edition):

Greene, Jonathan Michael. “Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium.” 2013. Web. 17 Jan 2021.

Vancouver:

Greene JM. Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium. [Internet] [Doctoral dissertation]. Mississippi State University; 2013. [cited 2021 Jan 17]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03052013-162917/ ;.

Council of Science Editors:

Greene JM. Examining the role of L-arginine in tissues of the fetoplacental unit and endometrium. [Doctoral Dissertation]. Mississippi State University; 2013. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03052013-162917/ ;

University of Rochester

27. England, Samantha Jean. Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus.

Degree: PhD, 2011, University of Rochester

URL: http://hdl.handle.net/1802/15948

► In the hematopoietic hierarchy, only stem cells are thought to be capable of long-term self-renewal. Erythroid progenitors derived from fetal or adult mammalian hematopoietic tissues… (more)

Subjects/Keywords: Erythropoiesis; Proerythroblast; Self-Renewal; Embryo; Fetus; Red Blood Cell

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APA (6^th Edition):

England, S. J. (2011). Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/15948

Chicago Manual of Style (16^th Edition):

England, Samantha Jean. “Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus.” 2011. Doctoral Dissertation, University of Rochester. Accessed January 17, 2021. http://hdl.handle.net/1802/15948.

MLA Handbook (7^th Edition):

England, Samantha Jean. “Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus.” 2011. Web. 17 Jan 2021.

Vancouver:

England SJ. Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1802/15948.

Council of Science Editors:

England SJ. Immature Erythroblasts with Extensive Ex Vivo Self-Renewal Capacity Emerge from the Early Mammalian Fetus. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/15948

28. Bernardes, Lisandra Stein. Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal.

Degree: PhD, Obstetrícia e Ginecologia, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/ ;

► INTRODUÇÃO: Não há, até o momento, método ideal de avaliação da função renal em fetos com dilatação de vias urinárias. A ultrassonografia é utilizada como… (more)

▼ INTRODUÇÃO: Não há, até o momento, método ideal de avaliação da função renal em fetos com dilatação de vias urinárias. A ultrassonografia é utilizada como um método não invasivo e alguns parâmetros, como o índice de líquido amniótico, foram descritos na predição de insuficiência renal. Entretanto, a sensibilidade é baixa e a detecção de alterações, muitas vezes, ocorre tardiamente na gestação. A avaliação bioquímica da urina ou sangue fetais acrescenta risco à gestação e, apesar de melhorar a detecção de insuficiência renal, tem sensibilidade e especificidade baixas. O Power Doppler tridimensional é um método capaz de quantificar fluxo em órgãos parenquimatosos e tem sido utilizado na quantificação de fluxo sanguíneo de órgãos fetais e placenta. Como fetos com obstrução de vias urinárias e insuficiência renal apresentam diminuição no número de glomérulos, a quantificação do fluxo renal ao Power Doppler tridimensional poderia aprimorar a avaliação da função renal desses fetos. OBJETIVOS: quantificar o fluxo renal ao Power Doppler tridimensional em fetos com suspeita de obstrução de vias urinárias e naqueles com morfologia renal normal, avaliar a influência da profundidade nos índices vasculares e comparar os índices nos fetos que evoluíram com e sem insuficiência renal no período pós-natal. MÉTODOS: fetos com hidronefrose bilateral e/ou dilatação vesical foram prospectivamente comparados com fetos sem malformações em relação à quantificação do fluxo renal ao Power Doppler tridimensional. Os parâmetros avaliados foram IV, IVF, IF e a profundidade. Após o nascimento, as crianças foram seguidas por uma equipe de nefrologia e urologia e, de acordo com a função renal, foram classificadas em 2 grupos: insuficiência renal e função renal normal. A vascularização renal foi avaliada em cada grupo e comparada ao grupo controle. RESULTADOS: vinte e três fetos com dilatação de vias urinárias e setenta e três com morfologia renal normal foram considerados para a análise estatística. Cinco crianças (21,7%) apresentaram insuficiência renal após o nascimento. IV e IVF foram significativamente mais baixos nos casos que apresentaram insuficiência renal do que naqueles com função renal normal (p=0,009 e 0,036, respectivamente). Os três índices corrigidos pela profundidade (IVCP, IFCP e IVFCP) variaram com a idade gestacional e a variação inter-observador melhorou quando eles foram utilizados. A porcentagem do IVCP e do IVFCP em relação à controles de mesma idade gestacional foi menor nos casos que desenvolveram insuficiência renal do que naqueles que evoluíram com função renal normal. CONCLUSÕES: IV e IVF foram significativamente mais baixos em fetos que evoluíram com insuficiência renal pósnatal, porém a profundidade foi um fator interferente importante. Desta forma, IVCP e IVFCP são potencialmente melhores na avaliação de fetos com suspeita de obstrução de vias urinárias. Como os índices corrigidos pela profundidade variam de acordo com a idade gestacional, é necessária a construção de curvas de normalidade por idade gestacional para… Advisors/Committee Members: Ruano, Rodrigo.

Subjects/Keywords: Feto; Fetus; Hidronefrose; Hydronephrosis; Insuficiência renal; Renal insufficiency; Ultrassonografia; Ultrassonography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bernardes, L. S. (2011). Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/ ;

Chicago Manual of Style (16^th Edition):

Bernardes, Lisandra Stein. “Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 17, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/ ;.

MLA Handbook (7^th Edition):

Bernardes, Lisandra Stein. “Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal.” 2011. Web. 17 Jan 2021.

Vancouver:

Bernardes LS. Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 17]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/ ;.

Council of Science Editors:

Bernardes LS. Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/ ;

University of Saskatchewan

29. Yarokhno, Yaroslav. Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers.

Degree: 2015, University of Saskatchewan

URL: http://hdl.handle.net/10388/ETD-2015-10-2318

► Bovine Genital Campylobacteriosis is characterized by early pregnancy loss and temporary infertility in cattle. The purpose of this project was to compare diagnostic approaches to… (more)

▼ Bovine Genital Campylobacteriosis is characterized by early pregnancy loss and temporary infertility in cattle. The purpose of this project was to compare diagnostic approaches to detect Campylobacter fetus subsp. venerealis and evaluate the efficacy of vaccination for Bovine Genital Campylobacteriosis. This thesis describes the results of two studies that compared different sample preparation methods for bovine vaginal mucus for real-time PCR and assessed a commercial vaccine in preventing infection and reproductive loss. The first study compared real-time PCR utilizing different bovine vaginal mucus sample preparation techniques to direct culture. The magnetic bead based protocol demonstrated higher sensitivity (48.4%, P=0.02) and lower specificity (78.9%, P=0.01) than the heat lysis protocol which involved an additional dilution step (Sens=29.4%, Spec=88.2%), but did not differ from the heat lysis protocol without sample dilution (Sens=35.0%, P=0.16; Spec=81.1%, P=0.62). The sample preparation method, designed for bovine preputial samples (Chaban et al. 2012. Can J of Vet Res; 76: 166), did not work well for vaginal mucus. All modifications of that method and magnetic bead based extraction technique had low sensitivity compared to culture probably due to the biophysical properties of vaginal mucus, which could cause loss of targeted DNA during processing, or repeated sample freezing and thawing. Release of DNA directly from vaginal mucus by a modified heat lysis protocol with consequent real-time PCR could be a promising rapid screening approach after validating on fresh samples. The second study compared the risk of infection and reproductive failure in heifers, vaccinated with a commercial multivalent vaccine containing C. fetus antigen, to heifers vaccinated with a comparable product without C. fetus, that were exposed to infected bulls. There was no significant difference between groups either in risk of Campylobacter fetus subsp. venerealis isolation (P>0.17) or in the proportion of heifers that cultured positive at least once (P=0.42), as well as in the median number times of cultured positive samples (P=0.24) and the time to first cultured positive (P=0.67). There was no difference by treatment in the weekly proportions of heifers diagnosed pregnant by either ultrasound (P>0.31) or serum concentration of pragnancy specific protein B (P>0.31) during the study, as well as in the time to first pregnancy for heifers ever diagnosed as pregnant (P=0.30) and those that remained pregnant at the end of the study (P=0.70). Similarly, the difference was not detected by treatment in the proportion of animals, ever detected pregnant during the study (P=0.57) and in pregnancy loss rates (P=0.28). However, heifers that aborted were 4 times more likely to be cultured positive than those that did not abort (P=0.01). Heifers that were not pregnant at the end of the study cultured positive 1.5 times more often than pregnant animals in treatment group (P=0.04), while in control group such difference was 4 times (P=0.01).… Advisors/Committee Members: Hendrick, Steve H., Waldner, Cheryl L., Hill, Janet E..

Subjects/Keywords: Bovine Genital Campylobacteriosis; Campylobacter fetus venerealis; real-time PCR; vaccination

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APA (6^th Edition):

Yarokhno, Y. (2015). Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2015-10-2318

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yarokhno, Yaroslav. “Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers.” 2015. Thesis, University of Saskatchewan. Accessed January 17, 2021. http://hdl.handle.net/10388/ETD-2015-10-2318.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yarokhno, Yaroslav. “Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers.” 2015. Web. 17 Jan 2021.

Vancouver:

Yarokhno Y. Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10388/ETD-2015-10-2318.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yarokhno Y. Diagnosis and vaccination for Bovine Genital Campylobacteriosis in beef heifers. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/ETD-2015-10-2318

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

30. Van Dyk, Barbara. Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/5543

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M.Tech.

It is difficult to manage a pregnancy when fetal age, health status or potential pregnancy risks are not known. The aim of this study… (more)

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M.Tech.

It is difficult to manage a pregnancy when fetal age, health status or potential pregnancy risks are not known. The aim of this study was to assess the impact of routine ultrasound screening as compared to selective use of ultrasound in the mid-trimester of pregnancy, on women using South African government health services. The three objectives investigated included assessment of the availability of reliable menstrual histories in the study population, the influence of ultrasound dating on obstetric management and the effect of ultrasound on pregnancy outcome due to the early detection of high risk pregnancies. A cluster randomised trial of 962 women was performed to test the hypothesis that midtrimester routine ultrasound screening in low risk pregnancies would result in improved antenatal care and perinatal outcome. Groups of eligible pregnant women were randomly selected to have either a routine scan followed by normal antenatal care or routine antenatal care which only allows for the selective use of ultrasound, in line with South African Antenatal Care Policy. Statistical analysis of the results confirmed that ultrasound dating is a more accurate predictor of the expected date of delivery when compared to other dating methods. Improved pregnancy dating resulted in a significant reduction in induction of labour for post-term pregnancy in the ultrasound screening group, suggesting a positive effect of ultrasound screening on obstetric management. No improvement was demonstrated in perinatal morbidity or mortality. The early detection of anomalous fetuses only led to one therapeutic abortion. The study did not possess the statistical power to demonstrate improved outcomes when multiple pregnancies were detected early in pregnancy. Currently there appears to be no urgent need to implement a routine antenatal screening programme in the Gauteng public health sector. In view of the fact that a third of the participants indicated that they were unsure of menstrual dates, and one third of the participants in the ultrasound screening group presented with an unreliable menstrual history, it is proposed that unsure dates be considered as a valid indication for the selective use of ultrasound in mid-trimester pregnancy.

Subjects/Keywords: Fetus - Ultrasonic imaging; Ultrasonics in obstetrics; Ultrasound screening

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Van Dyk, B. (2012). Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/5543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van Dyk, Barbara. “Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng.” 2012. Thesis, University of Johannesburg. Accessed January 17, 2021. http://hdl.handle.net/10210/5543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van Dyk, Barbara. “Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng.” 2012. Web. 17 Jan 2021.

Vancouver:

Van Dyk B. Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10210/5543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van Dyk B. Potential benefits of routine ultrasound screening in the mid-trimester of pregnancy, at primary health care level in Gauteng. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/5543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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