subject:(Fentanyl)

University of Canterbury

1. Kelly, Helana Ellen. The effect of titrated fentanyl on cough response in healthy participants.

Degree: MS, Speech and Language Sciences, 2014, University of Canterbury

► Background: One population prone to aspiration pneumonia and impaired cough is the postoperative patient. Postoperative pneumonia is the third most common complication among surgical patients… (more)

▼ Background: One population prone to aspiration pneumonia and impaired cough is the postoperative patient. Postoperative pneumonia is the third most common complication among surgical patients after urinary tract and wound infections (Wren, Martin, Yoon, & Bech, 2010). A patient who has their surgical course complicated by aspiration pneumonia has increased morbidity, increased length of hospital stay and places greater demands on the health system. Mortality rates are cited as high as 70% (Wren, et al., 2010). Despite the prevalence of postoperative pneumonia and the high morbidity and mortality rates, little is known about the effect of anaesthesia on swallowing and airway protection. This study investigated the effect of clinical doses of fentanyl on suppressed cough reflex in healthy participants. Materials and Methods: After receiving ethical approval, 14 young, healthy participants gave informed written consent and completed the study protocol. Each participant received a total of 2 mcg/kg of fentanyl in four doses administered at five-minute intervals. Fentanyl effect site concentrations (ESC) were estimated using a standard pharmacokinetic model. During the administration period, suppressed cough response testing (SCR) with nebulised citric acid was performed after each fentanyl dose. Citric acid was presented in increments of 0.2M from each participant’s baseline cough response until a present-strong response was achieved. During the post-administration period, SCR was compared with reducing effect site concentrations to determine the time course for resolution of cough suppression. Results: Suppressed cough threshold increased and decreased in parallel with modeled fentanyl effect site concentrations. Mean citric acid concentration increased from 0.5M at baseline to 0.6M after 0.5 mcg/kg of fentanyl, 0.7 M after 1 mcg/kg of fentanyl, 0.9M after 1.5 mcg/kg of fentanyl and 1.2M after 2 mcg/kg of fentanyl. Predicted effect site concentrations after final doses of fentanyl (2 mcg/kg) were 1.89 ng/mL (1.81-1.96), well within the range seen clinically in the postoperative period. After the final dose of fentanyl, participants had on average 3.4 increments of change in their cough response (at increments of 0.2M). Conclusion: SCR testing with citric acid is sensitive enough to mirror changes in fentanyl ESC in healthy, young participants. The degree of reflex suppression seen has been associated with an 8-fold increase in aspiration risk in the general medical patient with dysphagia (Miles, Moore, McFarlane, Lee, Allen, Huckabee, 2013). Further research into the application of SCR in the postoperative period may help clinical decisions regarding safety to commence oral intake.

Subjects/Keywords: fentanyl; opioid; cough; cough reflex

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kelly, H. E. (2014). The effect of titrated fentanyl on cough response in healthy participants. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/8890

Chicago Manual of Style (16^th Edition):

Kelly, Helana Ellen. “The effect of titrated fentanyl on cough response in healthy participants.” 2014. Masters Thesis, University of Canterbury. Accessed January 22, 2021. http://dx.doi.org/10.26021/8890.

MLA Handbook (7^th Edition):

Kelly, Helana Ellen. “The effect of titrated fentanyl on cough response in healthy participants.” 2014. Web. 22 Jan 2021.

Vancouver:

Kelly HE. The effect of titrated fentanyl on cough response in healthy participants. [Internet] [Masters thesis]. University of Canterbury; 2014. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.26021/8890.

Council of Science Editors:

Kelly HE. The effect of titrated fentanyl on cough response in healthy participants. [Masters Thesis]. University of Canterbury; 2014. Available from: http://dx.doi.org/10.26021/8890

Northeastern University

2. Gleba, Jessica. A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine.

Degree: PhD, School of Pharmacy, 2019, Northeastern University

URL: http://hdl.handle.net/2047/D20317948

► Postmortem redistribution (PMR) of drugs and their metabolites refers to the changes that occur in drug concentrations after death. Postmortem drug concentrations are also known… (more)

▼ Postmortem redistribution (PMR) of drugs and their metabolites refers to the changes that occur in drug concentrations after death. Postmortem drug concentrations are also known to show variations depending on sampling site as well as characteristics of the drugs themselves. Similar to antemortem pharmacokinetics, PMR is affected by lipophilicity, degree of ionization (e.g. pka) and volume of distribution (Vd) [1, 2]. While it was originally thought that the primary source of drug redistribution was diffusion from the cardiac tissues, recent research shows that the redistribution from solid organs such as the lungs, liver, and myocardium is a major contributor [3]. One complication in the interpretation of postmortem blood drug concentration is whether the measured drug concentration accurately reflects the concentration at death. It is important for the field of forensics to continue to research commonly used and/or abused drugs to provide further data into postmortem redistribution and establish significant reference literature. This literature is particularly valuable in medicolegal investigations since medical examiners and coroners use this information to determine a cause and manner of death. Heroin is a widely abused substance, involved in a large number of deaths annually. According to the CDC (Center for Disease Control and Prevention), in 2011 there was a 47% increase in heroin-related deaths and a 39% increase was observed between 2012 and 2013. Often morphine (metabolite of heroin), is treated as an indicator for heroin use and concentrations are often used to determine the cause of death [4]. Due to the increased prevalence of opioid use in the United States, establishing a relationship or understanding of postmortem drug concentrations among various samples collected at autopsy is essential. Postmortem distribution patterns of morphine have been established in blood, vitreous humor, brain and other samples from human autopsy material, and previously conducted animal studies. However, there are inconsistencies (e.g. gender, dose, sample site collection) among these studies. My dissertation provides an extensive insight into the postmortem redistribution of morphine, as well as the effect of fentanyl administration on morphine redistribution, that can be used throughout the forensic toxicology and pathology field to aide in the interpretation of toxicological results. My dissertation research not only advances the understanding into the postmortem redistribution of morphine but provides an LC-MS/MS method for the analysis of morphine (MOR), morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), normorphine (NM), fentanyl (Fent) and norfentanyl (NF). This LC-MS/MS method offers a rapid and sensitive analysis with minimal sample preparation, simple mobile phase composition and small sample volume. This method was validated using a fit-for use method validation using SWGTOX guidelines that is suitable for use in forensic, clinical and research laboratories.

Subjects/Keywords: Fentanyl; Morphine; Pharmacokinetics; Postmortem; Toxicology; Pharmacology; Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gleba, J. (2019). A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20317948

Chicago Manual of Style (16^th Edition):

Gleba, Jessica. “A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine.” 2019. Doctoral Dissertation, Northeastern University. Accessed January 22, 2021. http://hdl.handle.net/2047/D20317948.

MLA Handbook (7^th Edition):

Gleba, Jessica. “A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine.” 2019. Web. 22 Jan 2021.

Vancouver:

Gleba J. A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine. [Internet] [Doctoral dissertation]. Northeastern University; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2047/D20317948.

Council of Science Editors:

Gleba J. A Mechanism Based Forensic Investigation Into The Postmortem Redistribution Of Morphine. [Doctoral Dissertation]. Northeastern University; 2019. Available from: http://hdl.handle.net/2047/D20317948

3. Johansson, Herman. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.

Degree: Work Life and Social Welfare, 2015, University of Borås

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

► Inom ambulanssjukvård är en av ambulanssjuksköterskans uppgifter att kunna ge patienten adekvat smärtlindring. Tidigare har det krävts en intravenös infart för detta, men sedan… (more)

Subjects/Keywords: intranasal administrering; Fentanyl; akut smärta; sjuksköterskans erfarenheter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johansson, H. (2015). Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. (Thesis). University of Borås. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Herman. “Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.” 2015. Thesis, University of Borås. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Herman. “Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.” 2015. Web. 22 Jan 2021.

Vancouver:

Johansson H. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. [Internet] [Thesis]. University of Borås; 2015. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson H. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. [Thesis]. University of Borås; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Sklika, Eirini. Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία.

Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/36688

►

Objectives: to investigate comparatively the effect of remifentanil vs fentanyl on stress response and postoperative pain in persons with special needs undergoing day-case dental surgery.Study… (more)

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Objectives: to investigate comparatively the effect of remifentanil vs fentanyl on stress response and postoperative pain in persons with special needs undergoing day-case dental surgery.Study Design: forty-six adult patients with cognitive impairment were enrolled for dental surgery under general anesthesia. Patients in group F (n=23) received fentanyl 50 μg iv bolus and in group R (n=23) continuous infusion of remifentanil 0.5-1 μg/kg/min. The investigated parameters were: intraoperative hemodynamic response, tumor necrosis factor-α, substance-P, melatonin, cortisol and β-endorphin measurements and postoperative pain scores. Results: the two analgesics had similar effects on stress response and postoperative pain scores. However, the use of remifentanil prevented the intraoperative hemodynamic response. Conclusions: the choice of the opioid during dental surgery did not affect stress and inflammatory hormones, although remifentanil may render intraoperative management of hemodynamic responses easier. Both opioids are equally efficient for postoperative pain management following dental surgery in persons with special needs.

ΥΠΟΒΑΘΡΟ ΚΑΙ ΣΚΟΠΟΣ:Τα χειρουργεία ημέρας απαιτούν μια διαφορετική προσέγγιση σε άτομα με ειδικές ανάγκες (ΑΜΕΑ), που χρειάζονται γενική αναισθησία και μη λεκτική αξιολόγηση του πόνου. Συγκρίναμε την επίδραση της ρεμιφεντανύλης προς την φεντανύλη, τόσο στην διεγχειρητική απάντηση στο stress και στους μεσολαβητές της φλεγμονής, όσο και στον μετεγχειρητικό πόνο, κατά την διάρκεια χειρουργείων ημέρας οδοντοθεραπείας, σε ΑΜΕΑ, υπό γενική αναισθησία ΥΛΙΚΟ-ΜΕΘΟΔΟΣ :Σαράντα έξι ενήλικες ασθενείς με έκπτωση των γνωστικών τους λειτουργιών συμμετείχαν στην μελέτη. Οι ασθενείς στην ομάδα της φεντανύλης (Φ) έλαβαν εφάπαξ δόση 50 mcg iv, ενώ στην ομάδα της ρεμιφεντανύλης (Ρ) δόθηκε στάγδην έκχυση της ουσίας με ρυθμό 0,5-1 μg/kg/min iv. Και στις δύο ομάδες η αναισθησία διατηρήθηκε με προποφόλη. Διεγχειρητικά κατεγράφησαν οι αιμοδυναμικές παράμετροι των ασθενών, ενώ στον ορό του μετρήθηκαν μεσολαβητές της φλεγμονής (TNF, ουσία Ρ), ορμόνες του stress (μελατονίνη και κορτιζόλη) και ενδογενή οπιοειδή (β-ενδορφίνη). Ο μετεγχειρητικός πόνος αξιολογήθηκε για τις πρώτες 12 ώρες μετά από την επέμβαση, χρησιμοποιώντας την κλίμακα οπτικού αναλόγου Wong-Baker, από έναν ανεξάρτητο παρατηρητή.ΑΠΟΤΕΛΕΣΜΑΤΑ :Δεν παρατηρήθηκαν σημαντικές διαφορές, μεταξύ των δύο ομάδων, όσον αφορά τους μεσολαβητές της φλεγμονής, τις ορμόνες του stress και τον μετεγχειρητικό πόνο. Όμως σημαντικές διαφορές παρατηρήθηκαν στις αιμοδυναμικές παραμέτρους.ΣΥΜΠΕΡΑΣΜΑΤΑ :Η φεντανύλη και η ρεμιφεντανύλη είχαν παρόμοιες δράσεις, στις συγκεντρώσεις των κυκλοφορουσών ορμονών της φλεγμονώδους αντίδρασης και των ορμονών του stress, κατά την διάρκεια οδοντοθεραπείας σε ΑΜΕΑ. Φαίνεται ότι, η επίδραση της ρεμιφεντανύλης στην πρόληψη της αύξησης της αρτηριακής πίεσης και του καρδιακού ρυθμού, δεν επηρεάζει την απάντηση στο stress. Και τα δύο οπιοειδή μπορούν να θεωρηθούν εξίσου αποτελεσματικά στην αντιμετώπιση του μετεγχειρητικού πόνου,…

Subjects/Keywords: Γενική αναισθησία; Φεντανύλη; General anaesthesia; Fentanyl

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sklika, E. (2015). Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/36688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sklika, Eirini. “Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021. http://hdl.handle.net/10442/hedi/36688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sklika, Eirini. “Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία.” 2015. Web. 22 Jan 2021.

Vancouver:

Sklika E. Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10442/hedi/36688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sklika E. Βιολογική απάντηση στο stress και μελέτη του πόνου ατόμων με ειδικές ανάγκες υπό γενική αναισθησία για οδοντοθεραπεία. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/36688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oklahoma State University

5. Ciesielski, Austin Lee. Environmental contamination from clandestine drug manufacture.

Degree: Forensic Science, 2020, Oklahoma State University

URL: http://hdl.handle.net/11244/325456

► Drug abuse and drug seizures are on the rise across the United States. As drug prevalence increases, the public is more likely to come into… (more)

Subjects/Keywords: clandestine laboratory; contamination; environment; fentalog; fentanyl; methamphetamine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ciesielski, A. L. (2020). Environmental contamination from clandestine drug manufacture. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/325456

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ciesielski, Austin Lee. “Environmental contamination from clandestine drug manufacture.” 2020. Thesis, Oklahoma State University. Accessed January 22, 2021. http://hdl.handle.net/11244/325456.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ciesielski, Austin Lee. “Environmental contamination from clandestine drug manufacture.” 2020. Web. 22 Jan 2021.

Vancouver:

Ciesielski AL. Environmental contamination from clandestine drug manufacture. [Internet] [Thesis]. Oklahoma State University; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11244/325456.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ciesielski AL. Environmental contamination from clandestine drug manufacture. [Thesis]. Oklahoma State University; 2020. Available from: http://hdl.handle.net/11244/325456

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Cótes, Lourenço Candido. Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães.

Degree: Mestrado, Clínica Cirúrgica Veterinária, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09102012-105723/ ;

►

Os opióides de curta duração e de alta potencia analgésica, como o fentanil, embora amplamente utilizados em cães, ainda são pouco empregados pela via epidural… (more)

▼

Os opióides de curta duração e de alta potencia analgésica, como o fentanil, embora amplamente utilizados em cães, ainda são pouco empregados pela via epidural nesta espécie. O presente estudo teve como objetivo avaliar a associação do anestésico local lidocaína à morfina ou à combinação morfina-fentanil, pela via epidural. Foram analisados os efeitos cardiovasculares, respiratórios bem como a analgesia pós-operatória, em cães submetidos a cirurgia de joelho. Para tanto, 24 animais da espécie canina foram aleatoriamente divididos em 2 grupos. Todos os animais receberam acepromazina (0,05 mg/kg), foram induzidos com propofol (5 mg/kg) e mantidos em anestesia inalatória. Os animais do GRUPO I foram tratados com lidocaína (5mg/kg) associada a morfina (0,1mg/kg) e os animais do GRUPO II receberam, pela via epidural, a combinação lidocaína-morfina-fentanil, sendo este último na dose de 2µ/kg. Parâmetros como frequência cardíaca, respiratória, pressão arterial (sistólica, média e diastólica) foram mensurados, bem como pH e gases sanguíneos. Para a avaliação da analgesia foram utilizadas a escala Analógica-visual (EAV), a escala proposta por Lascelles, 1994 e a termoalgimetria. Amostras de sangue foram coletadas para posterior dosagem de cortisol e Interleucina-06. O período de avaliação imediata foi de 06 horas após a cirurgia, sendo os animais reavaliados no período de 24 horas após o procedimento. No tocante aos parâmetros cardiorrespiratórios os grupos se comportaram de maneira muito semelhante. Entretanto, pode-se observar que os animais tratados com a combinação lidocaína-fentanil-morfina apresentaram menor escore de dor quando avaliados pelas escalas do estudo no período pós-operatório. De fato verificou-se diferença significativa nos escores da EAV (p <0,05) nos tempos T180 e T360; na escala de Lascelles obteve-se diferença estatística nos tempos T180, T360 e T24h e na termoalgimetria houve diferença estatística nos tempos T180, T360 e T24h. A analgesia de resgate foi necessária em 3 animais do Grupo II, enquanto no Grupo I a necessidade desta medicação foi observada em 6 animais. Pode-se concluir, com os resultados obtidos, que a associação do fentanil no protocolo de anestesia epidural, promoveu adequada analgesia perioperatória, além de produzir um efeito sinérgico-residual, o que melhorou a analgesia pós-operatória, diminuindo a necessidade de analgesia de resgate.

Short duration opioids and high potency analgesics such as fentanyl, although widely used in dogs are seldom used for epidural anesthesia in this species. This study aimed to evaluate the association of lidocaine with morphine or morphine-fentanyl combination, epidurally. 24 dogs were randomly divided into two groups. All animals received acepromazine intramuscularlly (0.05 mg / kg), were induced with propofol (5 mg / kg) and maintained under inhalation anesthesia. The animals in group I were treated with lidocaine (5 mg / kg) combined with morphine (0.1 mg / kg) epidurally and the animals of group II received epidurally, the combination…

Advisors/Committee Members: Fantoni, Denise Tabacchi.

Subjects/Keywords: Cães; Dogs; Epidural; Epidural; Fentanil; Fentanyl; Lidocaína; lidocaine; Morfina; Morphine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cótes, L. C. (2011). Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09102012-105723/ ;

Chicago Manual of Style (16^th Edition):

Cótes, Lourenço Candido. “Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães.” 2011. Masters Thesis, University of São Paulo. Accessed January 22, 2021. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09102012-105723/ ;.

MLA Handbook (7^th Edition):

Cótes, Lourenço Candido. “Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães.” 2011. Web. 22 Jan 2021.

Vancouver:

Cótes LC. Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Jan 22]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09102012-105723/ ;.

Council of Science Editors:

Cótes LC. Avaliação do emprego epidural de morfina ou morfina-fentanil, associados à lidocaína, em cães. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09102012-105723/ ;

University of Tasmania

7. Williams, Gethin. Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems.

Degree: 1981, University of Tasmania

URL: https://eprints.utas.edu.au/21774/7/Williams_whole_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/21774/1/whole_WilliamsGethin1982_thesis.pdf

► A chemical synthesis of phosphocitrate (PC) was devised to facilitate investigation into its possible natural occurrence. Concomitantly, detection systems for characterising PC were developed utilizing… (more)

▼ A chemical synthesis of phosphocitrate (PC) was devised to facilitate investigation into its possible natural occurrence. Concomitantly, detection systems for characterising PC were developed utilizing thin layer chromatography, electrophoresis, isotachophoresis, and enzymatic and chemical PC assays. Synthesis of PC was effected by condensing 2-cyanoethyl phosphate (CEP) and triethyl citrate, followed by alkaline hydrolysis. CEP was considered to be the reagent-of-choice because of the ease of preparing [ 32P]-CEP from [32P]- inorganic phosphate enabling the production of [32P]-PC. An ion-exchange chromatographic system was developed to provide ultimate purification of PC, and it was characterised by 1H, 13C and 31P NMR spectroscopy. PC was demonstrated to inhibit potently hydroxyapatite (HAP) formation being more powerful than ATP and pyrophosphate. PC was also found to inhibit strongly calcium oxalate formation, its presence modifying crystal morphology. The unique structure of PC led to the proposal of a structure-activity relationship for inhibitors. Secondary factors influencing inhibitor power were elucidated and two groups of inhibitors were recognised. Type I inhibitors, which included PC, appeared to be crystal growth inhibitors, whereas Type II inhibitors were proposed to act by a range of mechanisms. The demonstration of a synergistic interaction between Type , I and Type II inhibitors was used to support the claim that in physiological fluids, PC could act as a potentiating agent. Comparison of a purified fraction from tissue samples with authenticated PC showed that PC occurs in kidney and liver of the rat and rabbit whilst other studies indicated that small amounts of PC were present in rabbit bone and human urine. More detailed studies indicated that PC was present, at a level of ca. 1 nmol/mg mitochondrial protein, in mitochondria, a subcellular organelle known to concentrate calcium. Administration of [ 32 P]-PC demonstrated that PC Was stable in blood but rapidly hydrolysed in kidney. Further, PC was rapidly taken up by bone, consistent with its physicochemical properties. These results suggested that although PC itself might be useful in treating some disorders of calcium metabolism, for other disorders, such as urolithiasis, a more stable analogue may be desirable. The nature of such analogues was discussed. Further experimentation indicated PC was compartmentalised within mitochondria and preliminary, work demonstrated that it could be biosynthesized there under the impetus of calcium loading. Data supported the proposal that compartmentalisation protected PC from the extramitochondrial lytic activity. The role of PC as a mitochondrial agent stabilising calcium phosphate deposits as amorphous spherules rather than HAP needles was described, and the effect of this stabilisation on membrane integrity, enzyme activity and calcium mobilisation was also detailed along with specific roles for PC in particular tissues, 'especially bone. Avenues for…

Subjects/Keywords: Phosphocitrate; Calcification; Phosphates; Fentanyl

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APA (6^th Edition):

Williams, G. (1981). Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/21774/7/Williams_whole_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/21774/1/whole_WilliamsGethin1982_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Williams, Gethin. “Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems.” 1981. Thesis, University of Tasmania. Accessed January 22, 2021. https://eprints.utas.edu.au/21774/7/Williams_whole_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/21774/1/whole_WilliamsGethin1982_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Williams, Gethin. “Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems.” 1981. Web. 22 Jan 2021.

Vancouver:

Williams G. Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems. [Internet] [Thesis]. University of Tasmania; 1981. [cited 2021 Jan 22]. Available from: https://eprints.utas.edu.au/21774/7/Williams_whole_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/21774/1/whole_WilliamsGethin1982_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Williams G. Phosphocitrate : its chemical synthesis, characterization, natural occurrence and role in calcifying systems. [Thesis]. University of Tasmania; 1981. Available from: https://eprints.utas.edu.au/21774/7/Williams_whole_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/21774/1/whole_WilliamsGethin1982_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Rana, Manjula. Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -.

Degree: Medicine, 2013, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/11667

None

Bibliography p. 85-95, Summary included

Advisors/Committee Members: Gurwara, A K.

Subjects/Keywords: Anaesthesiology; Propofol; Fentanyl; Ketamine

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APA (6^th Edition):

Rana, M. (2013). Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rana, Manjula. “Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -.” 2013. Thesis, Bundelkhand University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/11667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rana, Manjula. “Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -.” 2013. Web. 22 Jan 2021.

Vancouver:

Rana M. Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -. [Internet] [Thesis]. Bundelkhand University; 2013. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rana M. Induction characteristics of Propofol with Fentanyl and Ketamine (a comparative evaluation as total intravenous Anaesthesia); -. [Thesis]. Bundelkhand University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

9. Barbieri, Mia. The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery.

Degree: MMed, Anaesthesiology and Critical Care, 2016, Stellenbosch University

URL: http://hdl.handle.net/10019.1/100296

►

Background: Morphine directly activates cutaneous mast cells in a seemingly dose-dependent manner, resulting in the release of both histamine and tryptase into the bloodstream. Tryptase… (more)

▼

Background: Morphine directly activates cutaneous mast cells in a seemingly dose-dependent manner, resulting in the release of both histamine and tryptase into the bloodstream. Tryptase is almost exclusively stored in mast cells. Elevated serum tryptase concentrations serve as an indicator of mast cell activation and have become the most frequently used laboratory investigation in anaphylaxis. Following a clinical diagnostic dilemma our study was aimed at answering whether mast cell tryptase concentration remains useful in supporting the diagnosis of anaphylaxis even after administration of high dose morphine. Methods:We conducted a non-blinded, randomized controlled trial comparing the effects of fentanyl and high dose morphine, on serum mast cell tryptase concentrations. A power analysis was performed. Twenty adults undergoing cardiac surgery were randomly assigned to one of two opioid regimens. Both groups received a fentanyl bolus of 3 to 8 mcg/kg at induction. In the fentanyl group this was followed by a fentanyl infusion of 5 to 10 mcg/kg/hr until completion of surgery. Patients in the morphine group received morphine 1 mg/kg infused over thirty minutes. Baseline serum mast cell tryptase concentrations were determined directly prior to induction of anaesthesia and again 90 minutes after the start of the opioid infusion. The primary endpoint was statistical differences in tryptase concentrations between the morphine and fentanyl groups at the two time periods. Results: Ten patients of similar demographics were enrolled in each group. In the fentanyl group the second, 90-minute mast cell tryptase concentration was statistically significantly (10.1%) lower (p = 0.006) than baseline. Despite the 95% confidence interval of the difference between the means (-1.06 to -0.34 mcg/L) not including zero , this was not a clinically important difference. In the morphine group serum mast cell tryptase concentrations in the second (90 minute) sample were not statistically different from baseline values, the 95% confidence interval including zero. No between-group differences in tryptase concentration were detected. One patient in the morphine group exhibited a clinically significant 50,4% increase in tryptase concentrations, albeit from a high baseline of 11.9 mcg/L, which in this small study constitutes a prevalence of 10% (95% CI 1.8% to 40.4.) Conclusion: In this small pilot study, serum mast cell tryptase concentrations were unaffected by whether fentanyl or high dose morphine was administered. The null hypothesis, that there is no significant increase in serum mast cell concentrations after high dose morphine compared to fentanyl during cardiac anaesthesia and surgery, was therefore accepted. Larger studies are however needed to ensure a robust result, especially in the morphine group

Agtergrond: Morfien aktiveer kutane mastselle direk op 'n oënskynlik dosis-afhanklike wyse, wat lei tot die vrystelling van beide histamien en tryptase in die bloedstroom. Tryptase word feitlik uitsluitlik gestoor in mastselle.…

Advisors/Committee Members: Levin, Andrew I., Stellenbosch University. Faculty of Health Sciences. Dept. of Anaesthesiology and Critical Care..

Subjects/Keywords: Anaphylaxis; Morphine – Administration; Cardiac surgery; Mast cells; UCTD; Fentanyl

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barbieri, M. (2016). The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/100296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barbieri, Mia. “The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery.” 2016. Thesis, Stellenbosch University. Accessed January 22, 2021. http://hdl.handle.net/10019.1/100296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barbieri, Mia. “The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery.” 2016. Web. 22 Jan 2021.

Vancouver:

Barbieri M. The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery. [Internet] [Thesis]. Stellenbosch University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10019.1/100296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barbieri M. The effect of high dose morphine compared to fentanyl infusion on serum levels of mast cell tryptase during cardiac surgery. [Thesis]. Stellenbosch University; 2016. Available from: http://hdl.handle.net/10019.1/100296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

10. Padgett, Ashley Loren. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.

Degree: MS, Biomedical Sciences, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/174041

► Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to… (more)

▼ Designing perioperative analgesic regimen for ruminants is problematic as pain assessment is difficult and pregnancy adds additional considerations. The aim of this study was to assess the nociceptive properties of intramuscularly administered buprenorphine and transdermally administered fentanyl utilizing a composite pain score system. To better confirm that the observed abnormal behavior was related to pain, the current study attempted to characterize the nociceptive properties of the analgesic agents at a given plasma drug concentration, which has not previously been done. Additionally, the study characterized transplacental movement of analgesic agents via fetal plasma drug concentrations. In this study, we compared intramuscularly administered buprenorphine at a dose of 0.01 mg/kg every 8 hours for 48 hours starting at induction for surgery (n=6) to transdermal fentanyl patches (n=6) applied in the dorsal thorax region 24 hours before surgery at a dose of 2μg/kg/hr for postoperative pain. Ewe blood samples were collected and signs of pain and sedation were measured 24 hours before surgery (time -24), induction to surgery (time 0), and 2, 4, 6, 8, 12, 24, 36, 48 hours after. Using an indwelling fetal arterial catheter that was placed during the surgery, fetal blood pressure was recorded and blood samples were collected. Drug concentrations were measured in maternal and fetal plasma and amniotic fluid. The buprenorphine treated ewes exhibited more pain consistent behaviors than those treated with fentanyl, and their postoperative pain scores were significantly higher than the preoperative value. There were also significant differences in cardiovascular variables from the anesthesia records between the two groups. Overall, transdermal administration of fentanyl provided adequate analgesia with little adverse effects, making it a candidate for optimal postoperative pain management in sheep. Advisors/Committee Members: Washburn, Shannon E (advisor), Lepiz, Mauricio L (committee member), Fajt, Virginia R (committee member), Patterson, Carly (committee member).

Subjects/Keywords: transdermal fentanyl; opioids; pregnant sheep; buprenorphine; analgesia; anesthesia

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APA (6^th Edition):

Padgett, A. L. (2018). Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174041

Chicago Manual of Style (16^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Masters Thesis, Texas A&M University. Accessed January 22, 2021. http://hdl.handle.net/1969.1/174041.

MLA Handbook (7^th Edition):

Padgett, Ashley Loren. “Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep.” 2018. Web. 22 Jan 2021.

Vancouver:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1969.1/174041.

Council of Science Editors:

Padgett AL. Comparison of Transdermal Fentanyl and Intramuscularly Administered Buprenorphine for Postoperative Pain in Pregnant Sheep. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/174041

Addis Ababa University

11. ABULU, TESFA. ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE .

Degree: 2015, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/7333

► Background: The laryngeal mask airway (LMA) provides a useful alternative for airway management during spontaneous or controlled ventilation. Because of benefits like, less hemodynamic changes,… (more)

▼ Background: The laryngeal mask airway (LMA) provides a useful alternative for airway management during spontaneous or controlled ventilation. Because of benefits like, less hemodynamic changes, minimal increase in intraocular pressure after insertion; and a lower incidence of sore throat in adults, the use of LMA as an alternative to tracheal intubation is gaining popularity. So choosing an induction agent that better suppresses the airway reflexes, at usual induction dose, while, inserting LMA remains important. Objectives: To assess conditons of LMA insertion by the co-administration of Thiopentone, Fentanyl and Halothane in elective patients, scheduled for surgery at Tikur Anbessa Referral Hospital from March16- May 30, 2015. Methodology: -The study was conducted in TikurAnbessa Referral Hospital March16 - May 30, 2015.The study population was all elective patients, who was scheduled for elective surgery and for whom intubation with laryngeal mask airway was indicated. Institution based cross-sectional study was conducted. The total sample size is 42. Data was collected by observing the patients intubated with LMA under Thiopentone, Fentanyl and Halothane. Data was analyzed by using SPSS version 16. Association factors were checked by using cross-tabulation and chi-square. Results: - Total number of patients involved in this research was 42. Only patients with ASA classification of class I & II and Mallampati class I &II are involved. The mean age of the patients involved in the research was 18.13 ± 12.26. The mean weight was 41.92 ± 17.78. Concerning the responses of the patients to LMA insertion, 95.2% of the patients have adequate jaw relaxation. 41(97.6%) did not develop laryngeal spasm. In 92.7% of cases LMA was inserted during the first trial. Gagging did not occur in 90.5% of the cases. Coughing did not occur in 95.2% of the cases. . No movement is recorded in most of the cases (95.2%). There was no statistically significant change in the MAP and HR of the patients immediately, 5 minute and 10 minute after LMA insertion. Most of the patients (45.2%) start spontaneous breathing within the first 10sec after the combination of the drugs was administered. Conclusion: - Thiopentone 5.12mg/kg, fentanyl 1.2mcg/kg and halothane 3% mask ventilated with 100% oxygen for 2.7 min is effective for the insertion of LMA in elective patients. Advisors/Committee Members: MERON ABRAR (MSC) (advisor).

Subjects/Keywords: LMA insertion; Thiopentone; Fentanyl; Halothane; Tikur Anbessa Referral Hospital

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APA (6^th Edition):

ABULU, T. (2015). ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/7333

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ABULU, TESFA. “ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE .” 2015. Thesis, Addis Ababa University. Accessed January 22, 2021. http://etd.aau.edu.et/dspace/handle/123456789/7333.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ABULU, TESFA. “ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE .” 2015. Web. 22 Jan 2021.

Vancouver:

ABULU T. ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE . [Internet] [Thesis]. Addis Ababa University; 2015. [cited 2021 Jan 22]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7333.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ABULU T. ASSESSMENT OF LARYNGEAL MASK AIRWAY INSERTION CONDITIONS, WITH CO-ADMINISTRATION OF THIOPENTONE, FENTANYL AND HALOTHANE . [Thesis]. Addis Ababa University; 2015. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7333

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

12. Keating, Stephanie. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2013, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

► The objectives of this study were to determine the cardiopulmonary effects and pharmacokinetics of fentanyl in dogs during isoflurane anesthesia and during anesthetic recovery with… (more)

▼ The objectives of this study were to determine the cardiopulmonary effects and pharmacokinetics of fentanyl in dogs during isoflurane anesthesia and during anesthetic recovery with or without dexmedetomidine or acepromazine sedation. This was investigated in 7 healthy dogs using a randomized cross over study design. Dogs were given fentanyl as an initial IV loading dose (5 μg/kg) followed by an infusion (5 μg/kg/hr) for 120 minutes during isoflurane anesthesia and for 60 minutes following isoflurane discontinuation. Dogs received IV dexmedetomidine (2.5 μg/kg), acepromazine (0.05 mg/kg) or saline at the time of isoflurane discontinuation. Cardiopulmonary variables were measured and blood samples were obtained at multiple time points during the anesthetic maintenance and recovery phases. Plasma concentrations of fentanyl were measured using HPLC-MS, and subsequent population pharmacokinetic analysis was performed. During isoflurane anesthesia, fentanyl bolus administration resulted in significant changes in measured cardiopulmonary variables, however, many returned to baseline values during the maintenance of anesthesia. During anesthetic recovery, dexmedetomidine administration resulted in significant increases in PaCO2, and decreases in PvO2 and CI. Systemic arterial blood pressures were significantly lower in dogs receiving acepromazine, however CI and PvO2 were significantly higher compared to the other treatments. Analysis of fentanyl plasma concentrations showed that fentanyl pharmacokinetics best fit a 2-compartmental model, with average concentrations in the treatment groups ranging from 1.6 to 4.5 ng/mL during isoflurane anesthesia, and from 1.6 to 2.0 ng/mL during anesthetic recovery. Plasma concentrations of fentanyl were significantly higher with dexmedetomidine administration compared to the other treatments during the recovery period. Compared to the maintenance phase of anesthesia, anesthetic recovery with dexmedetomidine administration did not significantly change fentanyl pharmacokinetics, while acepromazine administration increased systemic and intercompartmental clearance, and recovery without sedation increased the central volume of distribution and systemic clearance. In conclusion, recovery from anesthesia with concurrent fentanyl administration, with or without sedation, caused clinically significant alterations in cardiopulmonary function that influenced fentanyl disposition in healthy dogs. Advisors/Committee Members: Kerr, Carolyn (advisor).

Subjects/Keywords: fentanyl; acepromazine; dexmedetomidine; recovery; sedation; isoflurane; dog; pharmacokinetics

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APA (6^th Edition):

Keating, S. (2013). The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

Chicago Manual of Style (16^th Edition):

Keating, Stephanie. “The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.” 2013. Doctoral Dissertation, University of Guelph. Accessed January 22, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548.

MLA Handbook (7^th Edition):

Keating, Stephanie. “The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery.” 2013. Web. 22 Jan 2021.

Vancouver:

Keating S. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. [Internet] [Doctoral dissertation]. University of Guelph; 2013. [cited 2021 Jan 22]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548.

Council of Science Editors:

Keating S. The cardiopulmonary effects and pharmacokinetics of fentanyl in the dog: The influence of isoflurane anesthesia and sedative administration during anesthetic recovery. [Doctoral Dissertation]. University of Guelph; 2013. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/6548

Freie Universität Berlin

13. Meyer, Johanna Charlotte. Regulation von Funktionen des µ-Opioidrezeptors durch den pH.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-27650

► Opioid analgesics constitute the most effective treatment of severe pain, but they also cause adverse and often fatal side effects. Selective targeting of peripheral opioid… (more)

▼ Opioid analgesics constitute the most effective treatment of severe pain, but they also cause adverse and often fatal side effects. Selective targeting of peripheral opioid receptors in injured tissue is a promising strategy to convey analgesia devoid of severe adverse effects. Drug targeting to injured tissue can be achieved by exploiting the acidic pH associated with inflammation. Yet, little is known on ligand recognition and signaling of opioid receptors at acidic pH. In the present study, I demonstrate that at acidic pH, μ-opioid receptor (MOR) responses are modulated depending on a specific structural property of bound ligands. In radioligand binding experiments, acidic pH reduced binding of naloxone (NLX) and [D-Ala2,N-Me- Phe4,Gly5-ol]-enkephalin (DAMGO), ligands that form hydrogen bond networks to histidine residue H297/6.52 within the receptor binding pocket. Furthermore, I observed impaired DAMGO-induced G-protein activation (as assessed by [35S]-GTPγS binding) and naloxone modulation of cAMP levels at acidic pH. In contrast, acidic pH did not alter G-protein activation and cAMP responses induced by fentanyl, a ligand that is unable to form hydrogen bonds to MOR residue H297/6.52. The exchange of residue H297/6.52 by alanine (A) abolished high-affinity binding of [3H]-NLX and [3H]-DAMGO, as well as DAMGO-induced G-protein activation. This mutation did not significantly alter fentanyl-induced Gprotein activation, but reduced cAMP responses to fentanyl. I conclude that H297/6.52A is crucial to effective binding of DAMGO and NLX to the MOR, while this residue contributes less to the binding of fentanyl. Overall, these findings indicate that acidic pH selectively impairs binding and consequent signaling of ligands that strongly depend on hydrogen bond formation to H297/6.52. To ensure maximum MOR binding and signaling in inflamed tissue, I suggest that opioid ligands should bind largely independent of H297/6.52. Advisors/Committee Members: female (gender), Tauber, Rudolf (firstReferee), Daumke, Oliver (furtherReferee).

Subjects/Keywords: µ-opioid receptor; opioids; fentanyl; naloxone; ddc:572

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APA (6^th Edition):

Meyer, J. C. (2020). Regulation von Funktionen des µ-Opioidrezeptors durch den pH. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Meyer, Johanna Charlotte. “Regulation von Funktionen des µ-Opioidrezeptors durch den pH.” 2020. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-27650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Meyer, Johanna Charlotte. “Regulation von Funktionen des µ-Opioidrezeptors durch den pH.” 2020. Web. 22 Jan 2021.

Vancouver:

Meyer JC. Regulation von Funktionen des µ-Opioidrezeptors durch den pH. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-27650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meyer JC. Regulation von Funktionen des µ-Opioidrezeptors durch den pH. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

14. Ke, Yiling. Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS.

Degree: MS, Biomedical Forensic Sciences, 2020, Boston University

URL: http://hdl.handle.net/2144/41277

► The opioid epidemic has become a serious public health problem in the United States. The increasing abuse of synthetic opioids has raised concerns in the… (more)

▼ The opioid epidemic has become a serious public health problem in the United States. The increasing abuse of synthetic opioids has raised concerns in the society. Fentanyl is a synthetic opioid analgesic which has resulted in an increasing number of drug overdoses since 2013. In addition, fentanyl analogs, originally manufactured for use as analgesics or animal tranquilizers, have emerged in the United States drug market. Fentanyl and its analogs, similar to other opioids, work as full µ-agonists, binding with µ-receptors in the brain. Fentanyl and its analogs elicit more potent effects compared to the traditional opioids being abused such as morphine or heroin. With the emergence of fentanyl analogs in the drug market, identifying and differentiating those analogs becomes a challenge due to their structural similarities to fentanyl. The purpose of this research was to develop a method of identifying and quantifying nine fentanyl analogs in urine and oral fluid using the QSight® Triple Quad LC-MS/MS, coupled with a Halo® C18, 2.7µm column. The method was validated based on AAFS Standards Board (ASB) Standard 036, Standard Practices for Method Validation in Forensic Toxicology. The analytes in this research included fentanyl, norfentanyl, acetyl fentanyl, carfentanil, cyclopropyl fentanyl, methoxyacetyl fentanyl, valeryl fentanyl, furanyl fentanyl and 4-anilino-N-phenethylpiperdine (4ANPP). All samples, calibrators, and quality controls (QC) were prepared by spiking certified reference standards into donated human urine or human oral fluid. Supported liquid extraction (SLE) was performed as the sample preparation method using ISOLUTE® SLE+ 1mL columns followed by evaporation. All samples were reconstituted with 200 µL methanol. The mobile phases used in this method were 5mM ammonium formate in Millipore water with 0.1% formic acid and methanol with 0.1% formic acid. A 10-minute LC method achieved complete resolution of the analytes, with specific retention times ranging from 3.5 to 5.7 minutes. For urine and oral fluid analysis, the calibration range for all analytes was established from 1 to 70 ng/mL. The resulting r2 values were greater than 0.988 for all analytes. Bias and precision were evaluated at 3, 25 and 60 ng/mL, and bias and percent coefficient of variation (%CV) for within and between run precision had acceptable values within ±20%. The limit of detection (LOD) was 0.1 ng/mL for most fentanyl analogs, with a LOD of 0.01 ng/mL for valeryl fentanyl and furanyl fentanyl. Carryover was not detected for any analytes in either matrix. Recovery of all compounds following SLE for both urine and oral fluid was above 50%. For urine, the ion enhancement and suppression of all analytes was within 25%. For oral fluid, the ion enhancement and suppression of most analytes was within 25% except valeryl fentanyl, which experienced suppression of 35%. The matrices analyzed had no interference effect on the detection or quantitation of analytes in this method. The interference effects of different commonly encountered… Advisors/Committee Members: Botch-Jones, Sabra R. (advisor).

Subjects/Keywords: Toxicology; Fentanyl analogs; HPLC; Supported liquid extraction; Tandem mass spectrometry

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APA (6^th Edition):

Ke, Y. (2020). Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41277

Chicago Manual of Style (16^th Edition):

Ke, Yiling. “Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS.” 2020. Masters Thesis, Boston University. Accessed January 22, 2021. http://hdl.handle.net/2144/41277.

MLA Handbook (7^th Edition):

Ke, Yiling. “Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS.” 2020. Web. 22 Jan 2021.

Vancouver:

Ke Y. Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2144/41277.

Council of Science Editors:

Ke Y. Detection and quantitation of nine fentanyl analogs in urine and oral fluid using QSight Triple Quad LC-MS/MS. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41277

Northeastern University

15. Phatak, Sanjana. Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives.

Degree: MS, Department of Chemistry and Chemical Biology, 2018, Northeastern University

URL: http://hdl.handle.net/2047/D20287231

► Fentanyl and fentanyl analogs are drugs of abuse that can also serve as common adulterants in drugs of abuse, and their potency causes many drug… (more)

Subjects/Keywords: biomimiks; DART-MS; fentanyl; LC-MS/MS; metabolism

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APA (6^th Edition):

Phatak, S. (2018). Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives. (Masters Thesis). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20287231

Chicago Manual of Style (16^th Edition):

Phatak, Sanjana. “Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives.” 2018. Masters Thesis, Northeastern University. Accessed January 22, 2021. http://hdl.handle.net/2047/D20287231.

MLA Handbook (7^th Edition):

Phatak, Sanjana. “Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives.” 2018. Web. 22 Jan 2021.

Vancouver:

Phatak S. Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives. [Internet] [Masters thesis]. Northeastern University; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2047/D20287231.

Council of Science Editors:

Phatak S. Utilizing liquid chromatography tandem mass spectrometry and direct analysis in real time to assess the metabolism of fentanyl derivatives. [Masters Thesis]. Northeastern University; 2018. Available from: http://hdl.handle.net/2047/D20287231

Boston University

16. Pellegrini, Eric. Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/19442

► The opioid fentanyl is becoming an increasingly popular drug of abuse across the United States. With a potency up to 100 times greater than the… (more)

Subjects/Keywords: Public health; Fentanyl; Naloxone; Opioids; Overdose; Public access; Public policy

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APA (6^th Edition):

Pellegrini, E. (2016). Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19442

Chicago Manual of Style (16^th Edition):

Pellegrini, Eric. “Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic.” 2016. Masters Thesis, Boston University. Accessed January 22, 2021. http://hdl.handle.net/2144/19442.

MLA Handbook (7^th Edition):

Pellegrini, Eric. “Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic.” 2016. Web. 22 Jan 2021.

Vancouver:

Pellegrini E. Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2144/19442.

Council of Science Editors:

Pellegrini E. Analysis of increased public access to naloxone as a method to control the recent fentanyl epidemic. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19442

Boston University

17. Moore, Amanda Marie. Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry.

Degree: MS, Biomedical Forensic Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/23836

► The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United… (more)

▼ The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the opioid epidemic. In 2016, the Drug Enforcement Administration temporarily placed three fentanyl analogs (beta-hydroxythiofentanyl, butyryl fentanyl, and furanyl fentanyl) under Schedule I due to their imminent threat to public health. These drugs elicit analgesic effects similar to heroin making them desirable drugs to abuse. Novel fentanyl analogs and designer opioids are expected to become more prominent in forensic casework in the near future as the opioid epidemic continues. These drugs can be seen in forensic seized drug and urine casework samples either alone or mixed with other drugs of abuse. It is therefore necessary to have an efficient methodology to identify these new compounds. Currently, gas chromatography-mass spectrometry (GC/MS) is used to identify drugs of abuse and is considered the “gold standard” in forensic casework. However, analysis times can often range from 15 to 60 minutes in length. Another drawback is the need for spectral library matching, which requires analytical reference materials for identification. Therefore, the identification of novel fentanyl analogs and designer drugs is limited until a reference material becomes available. In this study, direct sample analysis time-of-flight mass spectrometry (DSA-TOFMS) was evaluated to provide rapid identification of fentanyl and other synthetic opioids in seized drug and urine casework samples. DSA is a direct ambient ionization source, which requires no chromatography and minimal sample preparation. TOFMS is a high resolution mass spectrometer that uses collision-induced dissociation (CID) to produce precursor ion and characteristic fragmentation ions, which provide additional structural and molecular formula information, allowing for the identification of compounds without a reference material. The analytes explored in this study include: heroin, 6-monoacetylmorphine (6-MAM), morphine, fentanyl, norfentanyl, 4-anilino-N-phenethylpiperidine (4-ANPP), acetyl fentanyl, beta-hydroxythiofentanyl, butyryl fentanyl, furanyl fentanyl, valeryl fentanyl, AH-7921, U-47700, buprenorphine, norbuprenorphine, desomorphine, MT-45, W-15, and W-18. Direct sample analysis time-of flight mass spectrometry (DSA-TOFMS) is a novel instrumentation that could be utilized in the forensic sciences field to qualitatively identify illicit substances in casework samples. In this study, 19 compounds of interest containing heroin, fentanyl, fentanyl analogs, and other synthetic opioids were evaluated using DSA-TOFMS. DSA-TOFMS abbreviated the workload of the analysis and was utilized to provide precursor ion and characteristic fragmentation ions within an analysis time of 20 seconds. Certified reference standards were used to optimize instrumentation settings, to determine precursor ions and…

Subjects/Keywords: Chemistry; Fentanyl; Direct sample analysis time of flight mass spectrometry

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APA (6^th Edition):

Moore, A. M. (2017). Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23836

Chicago Manual of Style (16^th Edition):

Moore, Amanda Marie. “Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry.” 2017. Masters Thesis, Boston University. Accessed January 22, 2021. http://hdl.handle.net/2144/23836.

MLA Handbook (7^th Edition):

Moore, Amanda Marie. “Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry.” 2017. Web. 22 Jan 2021.

Vancouver:

Moore AM. Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2144/23836.

Council of Science Editors:

Moore AM. Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23836

University of Oxford

18. Goddard, Helen. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.

Degree: PhD, 2002, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

► Ischaemic periods which lust only several minutes can result in a reversible reduction in cardiac contractility known as cardiac stunning. This is a potentially dangerous… (more)

Subjects/Keywords: 615; Fentanyl; Halothane; Isoflurane

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APA (6^th Edition):

Goddard, H. (2002). Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

Chicago Manual of Style (16^th Edition):

Goddard, Helen. “Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.” 2002. Doctoral Dissertation, University of Oxford. Accessed January 22, 2021. http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018.

MLA Handbook (7^th Edition):

Goddard, Helen. “Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes.” 2002. Web. 22 Jan 2021.

Vancouver:

Goddard H. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. [Internet] [Doctoral dissertation]. University of Oxford; 2002. [cited 2021 Jan 22]. Available from: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018.

Council of Science Editors:

Goddard H. Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes. [Doctoral Dissertation]. University of Oxford; 2002. Available from: http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270018

University of Arizona

19. Nenad, Robert Eugene, Jr., 1955-. THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS .

Degree: 1986, University of Arizona

URL: http://hdl.handle.net/10150/276356

Subjects/Keywords: Cimetidine.; Ranitidine.; Fentanyl.; Narcotics.

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APA (6^th Edition):

Nenad, Robert Eugene, Jr., 1. (1986). THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/276356

Chicago Manual of Style (16^th Edition):

Nenad, Robert Eugene, Jr., 1955-. “THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS .” 1986. Masters Thesis, University of Arizona. Accessed January 22, 2021. http://hdl.handle.net/10150/276356.

MLA Handbook (7^th Edition):

Nenad, Robert Eugene, Jr., 1955-. “THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS .” 1986. Web. 22 Jan 2021.

Vancouver:

Nenad, Robert Eugene, Jr. 1. THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS . [Internet] [Masters thesis]. University of Arizona; 1986. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10150/276356.

Council of Science Editors:

Nenad, Robert Eugene, Jr. 1. THE INFLUENCE OF H-2 RECEPTOR ANTAGONISTS, CIMETIDINE AND RANITIDINE, ON THE PHARMACOKINETICS OF FENTANYL IN DOGS . [Masters Thesis]. University of Arizona; 1986. Available from: http://hdl.handle.net/10150/276356

Virginia Tech

20. Williamson, Allan John. Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia.

Degree: MS, Biomedical and Veterinary Sciences, 2017, Virginia Tech

URL: http://hdl.handle.net/10919/86614

► Fentanyl has historically been used to reduce inhalant anesthetic requirements in the dog, with the end goal of reducing detrimental cardiovascular effects seen with their… (more)

▼ Fentanyl has historically been used to reduce inhalant anesthetic requirements in the dog, with the end goal of reducing detrimental cardiovascular effects seen with their use. While fentanyl has been investigated in this context with the older agent enflurane, this agent is no longer in common use. In the current literature, no studies exist that compare the effects of low and high doses of fentanyl on cardiovascular function in dogs anesthetized with isoflurane. In previous literature, a high dose of fentanyl improved cardiovascular function in enflurane anesthetized dogs only following correction of bradycardia associated with its use. The objective of this study was to evaluate the effect of two doses of fentanyl on isoflurane requirement in the dog, followed by an evaluation of cardiovascular function in the isoflurane-anesthetized dog at equivalent depth of anesthesia. The hypothesis was that fentanyl would reduce inhalant requirements in a dose dependent fashion, and that cardiovascular function would increase with fentanyl administration only following correction of bradycardia. A total of 8 healthy adult male beagle dogs were enrolled in this study, which was performed in a randomized cross-over design. Minimum Alveolar Concentration (MAC) was determined in these dogs via a 30 mA electric stimulation both before and after administration of a low (loading dose 30 µg/kg, continuous rate infusion (CRI) of 0.2 µg/kg/minute) or high (loading dose 90 µg/kg, CRI 0.8 µg/kg/min) dose of fentanyl. A 7-day washout was observed between experimental days. Following MAC determination, in a subsequent anesthetic episode animals were placed at a MAC multiple of 1.3 and cardiovascular and blood gas parameters were evaluated before and after each fentanyl dose in the presence and absence of bradycardia. Fentanyl decreased MAC in a dose-dependent fashion (p < 0.001), with the low dose reducing MAC by about 42% and the high dose by about 77%. MAC reduction, however, did not translate into improvement in cardiovascular function, with a significant reduction in cardiac index and oxygen delivery noted with both doses (p < 0.01) that was not different between treatments. Normal mean arterial pressures were maintained with both treatments despite these effects. Only with the high dose, however, correction of bradycardia caused an increase in both cardiac index and oxygen delivery (p < 0.02) when compared to isoflurane alone. In clinically healthy dogs, administration of a high dose of fentanyl increased cardiac function following correction of bradycardia, but a decrease was observed when bradycardia went uncorrected. Further studies are needed in order to evaluate these effects in clinical patients. Advisors/Committee Members: Neves Soares, Joao Henrique (committeechair), Pavlisko, Noah Dawson (committee member), Henao Guerrero, Piedad Natalia (committee member).

Subjects/Keywords: Canine; Fentanyl; Minimum Alveolar Concentration; Balanced Anesthesia; Cardiovascular

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APA (6^th Edition):

Williamson, A. J. (2017). Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/86614

Chicago Manual of Style (16^th Edition):

Williamson, Allan John. “Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia.” 2017. Masters Thesis, Virginia Tech. Accessed January 22, 2021. http://hdl.handle.net/10919/86614.

MLA Handbook (7^th Edition):

Williamson, Allan John. “Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia.” 2017. Web. 22 Jan 2021.

Vancouver:

Williamson AJ. Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia. [Internet] [Masters thesis]. Virginia Tech; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10919/86614.

Council of Science Editors:

Williamson AJ. Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia. [Masters Thesis]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/86614

University of Sydney

21. Viljoen, André John. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .

Degree: 2011, University of Sydney

URL: http://hdl.handle.net/2123/7255

► ABSTRACT Background: The death of a patient under dental intravenous sedation in New South Wales, Australia, in 2002 while being treated by a dentist with… (more)

▼ ABSTRACT Background: The death of a patient under dental intravenous sedation in New South Wales, Australia, in 2002 while being treated by a dentist with appropriate training in intravenous conscious sedation (ICS), (Graduate Diploma in Clinical Dentistry; Conscious Sedation and Pain Control, University of Sydney) has once again brought into question the safety of ICS. The cause of death was irreversible cerebral hypoxia following a cardiac arrest, which was precipitated by numerous periods of ever-deepening hypoxaemia. Aim: This retrospective, quality-assurance audit investigated whether safe oxygen saturation levels could be maintained during single operator/sedationist dental sedations, when operating within the joint Royal Australasian College of Dental Surgeons (RACDS) and Australian and New Zealand College of Anaesthetists (ANZCA) PS21 guidelines for conscious sedation. Methodology: Safe oxygen saturation levels were defined as pulse oximeter readings of 94% and above. The recording of two or more readings of less than 94% during a sedation procedure was defined as the outcome of interest. The association of the variables of age (eighteen and over), gender, weight, the American Society of Anesthesiologists (ASA) Classification I or II and the use of propofol in addition to midazolam and fentanyl, to low saturations, was examined. Two sub-cohorts were randomly generated: 1,750 patients were sedated with iv midazolam and fentanyl and 1,750 patients received propofol, in sub-anaesthetic increments, in addition to midazolam and fentanyl. All patients received supplemental oxygen. Initial sedation was established using midazolam and fentanyl in both sub-cohorts. The second sub-cohort received sub-anaesthetic increments of propofol during times of noxious stimulation. Statistical analysis of the data used cross-tabulation of the variables by outcome, an associated chi- squared test and corresponding logistic regression analysis, together with odds ratio (OR) and a 95% confidence interval (95%CI). Results: Patient exposure to two or more oxygen de-saturations below 94% was uncommon. The null hypothesis could not be rejected because there was no significant difference between the saturation levels recorded for each sub-cohort (μ1 - μ2 = 0), where μ1 was the cohort that received propofol in addition to midazolam and fentanyl, and μ2 was the cohort that received midazolam and fentanyl only. Analysis of the two population groups found them to be quite different in make-up. Had the two population groups been similar in make-up, then μ1 - μ2 may not have equaled 0, and the outcome of the hypothesis test may have been to reject H0. The variables that were significantly associated with low saturations were age, gender and weight. The data showed that males were three times more likely than females to experience low saturations. Patients 45 years and older were nearly eight times more likely to experience low saturations than patients 25 years or younger. Patients classified as being in the gender- specific high weight group…

Subjects/Keywords: safe oxygen saturation levels; midazolam; fentanyl; propofol; intravenous dental sedation

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APA (6^th Edition):

Viljoen, A. J. (2011). Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/7255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Viljoen, André John. “Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .” 2011. Thesis, University of Sydney. Accessed January 22, 2021. http://hdl.handle.net/2123/7255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Viljoen, André John. “Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases .” 2011. Web. 22 Jan 2021.

Vancouver:

Viljoen AJ. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . [Internet] [Thesis]. University of Sydney; 2011. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2123/7255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Viljoen AJ. Analysis of oxygen saturation levels recorded during dental intravenous sedations - a retrospective quality assurance of 3500 cases . [Thesis]. University of Sydney; 2011. Available from: http://hdl.handle.net/2123/7255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Bowling Green State University

22. Canfield, Jeremy. Drug detection using Eosin Y and cobalt thiocyanate paper assays.

Degree: MS, Forensic Science, 2020, Bowling Green State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586543403777358

► Eosin Y is a new color test that has potential for use in detecting illicit drugs that has not been studied extensively. In this study,… (more)

Subjects/Keywords: Chemistry; Drug detection; presumptive tests; color tests; fentanyl; forensic

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APA (6^th Edition):

Canfield, J. (2020). Drug detection using Eosin Y and cobalt thiocyanate paper assays. (Masters Thesis). Bowling Green State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586543403777358

Chicago Manual of Style (16^th Edition):

Canfield, Jeremy. “Drug detection using Eosin Y and cobalt thiocyanate paper assays.” 2020. Masters Thesis, Bowling Green State University. Accessed January 22, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586543403777358.

MLA Handbook (7^th Edition):

Canfield, Jeremy. “Drug detection using Eosin Y and cobalt thiocyanate paper assays.” 2020. Web. 22 Jan 2021.

Vancouver:

Canfield J. Drug detection using Eosin Y and cobalt thiocyanate paper assays. [Internet] [Masters thesis]. Bowling Green State University; 2020. [cited 2021 Jan 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586543403777358.

Council of Science Editors:

Canfield J. Drug detection using Eosin Y and cobalt thiocyanate paper assays. [Masters Thesis]. Bowling Green State University; 2020. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1586543403777358

Wright State University

23. Strayer, Kraig Edward. A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations.

Degree: MS, Chemistry, 2018, Wright State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317

► The United States and numerous other countries worldwide are currently experiencing a public health crisis due to the abuse of illicitly manufactured fentanyl (IMF) and… (more)

Subjects/Keywords: Chemistry; Analytical Chemistry; Method Development; Fentanyl; LC-MSMS

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APA (6^th Edition):

Strayer, K. E. (2018). A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations. (Masters Thesis). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317

Chicago Manual of Style (16^th Edition):

Strayer, Kraig Edward. “A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations.” 2018. Masters Thesis, Wright State University. Accessed January 22, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317.

MLA Handbook (7^th Edition):

Strayer, Kraig Edward. “A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations.” 2018. Web. 22 Jan 2021.

Vancouver:

Strayer KE. A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations. [Internet] [Masters thesis]. Wright State University; 2018. [cited 2021 Jan 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317.

Council of Science Editors:

Strayer KE. A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations. [Masters Thesis]. Wright State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317

University of Tennessee – Knoxville

24. Phillips, Tricia Marie. Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa.

Degree: 2020, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_graddiss/5897

► The opioid epidemic has had a strong presence in the United States in recent years. Drug overdose deaths involving opioids have skyrocketed and the lacing… (more)

▼ The opioid epidemic has had a strong presence in the United States in recent years. Drug overdose deaths involving opioids have skyrocketed and the lacing of heroin with fentanyl has played a significant role in this. In order to investigate the dynamics behind the opioid epidemic and predict its trajectory, we formulate a system of ordinary differential equations that incorporate the movement of individuals among classes of opioid use. We estimate parameter values by fitting to Tennessee data since the time the epidemic was established in the state. The trajectory of the epidemic suggests the number of addicts and overdose deaths will increase over the next few years and is driven by the size of the heroin/fentanyl addicted class. We measure the sensitivity of the size of the opioid addicted classes to each of the parameters at the beginning of 2023. From these results, with the hopes of mitigating the increasing trajectory of the epidemic in the near future, management scenarios for decreasing the number of addicted individuals and overdose deaths from 2020-2023 are explored. The most effective include increasing accessibility to treatment programs, monitoring individuals who have stably recovered, and increasing the use of opioid overdose-reversal drugs. Khaya senegalensis is a tree species in Benin, West Africa that is harvested both lethally and non-lethally for its non-timber forest products by the local people for cultural and economic reasons. Both adult and juvenile trees are harvested which affects various vital rates for the tree population. To investigate the effect of size-dependent harvesting strategies on tree population dynamics, we develop a size-structured, seasonal system of difference equations with time-varying harvest for this tree species. Using data from a specific population of the species, the Soassararou population, we estimate harvesting rates and rates affected by harvest for our harvesting model applied to the Soassararou and Nipuni populations. Eigenvalue analysis is then carried out to compare population dynamics.

Subjects/Keywords: opioids; heroin; fentanyl; harvesting; modeling; ordinary differential equations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Phillips, T. M. (2020). Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/5897

Chicago Manual of Style (16^th Edition):

Phillips, Tricia Marie. “Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa.” 2020. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed January 22, 2021. https://trace.tennessee.edu/utk_graddiss/5897.

MLA Handbook (7^th Edition):

Phillips, Tricia Marie. “Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa.” 2020. Web. 22 Jan 2021.

Vancouver:

Phillips TM. Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2020. [cited 2021 Jan 22]. Available from: https://trace.tennessee.edu/utk_graddiss/5897.

Council of Science Editors:

Phillips TM. Data-Driven Modeling of the Heroin and Fentanyl Epidemic and the Harvesting of Trees in West Africa. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2020. Available from: https://trace.tennessee.edu/utk_graddiss/5897

25. Souto, Maria Teresa de Mello Rêgo. Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia.

Degree: Mestrado, Clínica Cirúrgica Veterinária, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/ ;

►

Os equinos são comumente anestesiados com agentes voláteis em procedimentos cirúrgicos acima de 60 minutos, resultando em depressão cardiovascular dosedependente, contribuindo para uma alta taxa… (more)

▼

Os equinos são comumente anestesiados com agentes voláteis em procedimentos cirúrgicos acima de 60 minutos, resultando em depressão cardiovascular dosedependente, contribuindo para uma alta taxa de mortalidade. Sendo assim, este estudo objetivou determinar se o fentanil, em infusão contínua, seria capaz de diminuir a fração expirada de isoflurano, promovendo estabilidade cardiovascular transoperatória e uma melhor recuperação após cirurgia de artroscopia, em comparação à infusão de lidocaína ou quetamina, durante a manutenção da anestesia com isoflurano. Para tanto foram utilizados 20 equinos de 3 a 8 anos e pesando 350 a 500kg, submetidos a cirurgia de artroscopia em decúbito dorsal. Os animais foram divididos aleatoriamente em 4 grupos: GL (1,5 mg/kg em bolus e infusão de 0,15mg/kg/min) ; GQ (2mg/kg em bolus e infusão de 0,2mg/kg/min); GF (7µg/kg em bolus e infusão de 0,7µg/kg/min) e GI que não recebeu infusão de nenhum fármaco adjuvante. Foram avaliados os parâmetros cardiovasculares (FC, PAM, PAS e PAD), ventilatórios e de oxigenação (PaO2, PaCO2, Compl e Rva), fração expirada de isoflurano [ISSO](Fexp%), e qualidade de recuperação. Em relação à [ISSO] (Fexp%) as maiores quedas foram observadas no momento 30bolus em todos os grupos, que utilizaram adjuvantes, comparados ao momento basal sendo, GL (1,50 para 0,90%) GQ (1,44 para 0,96%) e GF (1,32 para 0,96%). Observou-se que após 15 minutos da interrupção da infusão contínua de fentanil e lidocaína a fração expirada de isoflurano foi aumentada GL 25% e GF 45%. Apesar de não ter havido diferença estatística, o GF apresentou escore de recuperação menor 16,8 pontos, GL 24,6; GQ 30,0 e GI 31,8 pontos. Conclui-se então que o uso do fentanil foi capaz de reduzir a fração expirada de isoflurano em até 43%, não observando qualquer efeito colateral no momento da recuperação após re-sedação com xilazina 0,5mg/kg.

Volatile anesthetics are commonly used in horse anesthesia in surgical procedures over 60 minutes, resulting in a dose-dependent cardiovascular depression, contributing to a high mortality rate. Thus, the aimed this study was determine whether fentanyl continuous rate infusion would be able to reduce end tidal isoflurane, promoting intraoperative cardiovascular stability and a better recovery after arthroscopic surgery, when compared to lidocaine or ketamine infusion during maintenance of anesthesia with isoflurane. Therefore, 20 horses aging 3-8 years and weighing 350 to 500 kg underwent arthroscopic surgery in dorsal recumbence. The animals were randomly divided into four groups: GL (1.5 mg/kg bolus and 0.15 mg/kg/min infusion rate of lidocaine), GQ (2 mg/kg bolus and 0.2 mg/kg/min infusion of ketamine); GF (7µg/kg bolus and 0.7 mg/kg/min infusion rate of fentanyl) and GI did not receive any adjuvant infusion. Cardiovascular parameters (HR, MBP, SBP and DBP), ventilatory and oxygenation (PaO2, PaCO2, Cst and Rva), end tidal isoflurano [ISO] (Fexp%), and quality of recovery were evaluated. Regarding [ISO] (Fexp%) the highest decreases were…

Advisors/Committee Members: Ambrósio, Aline Magalhães.

Subjects/Keywords: Continuous infusion; Equinos; Fentanil; Fentanyl; Horses; Infusão contínua; Ketamine; Lidocaína; Lidocaine; Quetamina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souto, M. T. d. M. R. (2010). Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/ ;

Chicago Manual of Style (16^th Edition):

Souto, Maria Teresa de Mello Rêgo. “Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia.” 2010. Masters Thesis, University of São Paulo. Accessed January 22, 2021. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/ ;.

MLA Handbook (7^th Edition):

Souto, Maria Teresa de Mello Rêgo. “Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia.” 2010. Web. 22 Jan 2021.

Vancouver:

Souto MTdMR. Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 22]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/ ;.

Council of Science Editors:

Souto MTdMR. Estudos clínicos da infusão contínua de fentanil, quetamina ou lidocaína sobre o requerimento de isoflurano em cavalos submetidos à cirurgia de artroscopia. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-27022012-110748/ ;

26. 김, 지은. Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis.

Degree: 2014, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/10941 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017473

►

Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and non-pharmacological interventions… (more)

▼

Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and non-pharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled trials comparing the pharmacological or nonpharmacological interventions with the controls to prevent FIC; we included 28 studies retrieved from Pub-Med, Embase, and Cochrane Library. Overall incidence of FIC was approximately 31%. Lidocaine [odds ratio (OR) = 0.29, 95% confidence interval (CI) 0.21 – 0.39], N-methyl-D-aspartate (NMDA) receptor antagonists [OR = 0.09, 95% CI 0.02 – 0.42], propofol [OR = 0.07, 95% CI 0.01 – 0.36], α2 agonists [OR = 0.32, 95% CI 0.21 – 0.48], β2 agonists [OR = 0.10, 95% CI 0.03 – 0.30], fentanyl priming [OR = 0.33, 95% CI 0.19 – 0.56], and slow injection of fentanyl [OR = 0.25, 95% CI 0.11 – 0.58)] were effective in decreasing the incidence of FIC, whereas atropine [OR = 1.10, 95% CI 0.58 – 2.11] and benzodiazepines [OR = 2.04, 95% CI 1.33 – 3.13] were not effective. This meta-analysis found that lidocaine, NMDA receptor antagonists, propofol, α2 agonists, β2 agonists, and priming dose of fentanyl were effective in preventing FIC, but atropine and benzodiazepines were not. Slow injection of fentanyl was effective in preventing FIC, but results depend on the speed of administration.

펜타닐 유도성 기침은 마취 유도시에 펜타닐을 일회 정주한 후 종종 관찰된다. 본 메타분석에서는 펜타닐 유도성 기침의 발생률을 줄이기 위해 시행되는 약물적 혹은 비약물적 중재법들의 효능을 평가하였다. 펜타닐 유도성 기침 예방을 위하여 대조군과 약물적 혹은 비약물적 중재법들을 비교한 무작위대조군연구들을 대상으로 하였다. Pub-Med, Embase, Cochrane Library을 기반으로 하여 총 28 개의 연구들이 분석되었다. 펜타닐 유도성 기침의 전반적인 발생률은 31% 이었다. 리도카인 [odds ratio (OR) = 0.29, 95% confidence interval (CI) 0.21 – 0.39], N-methyl-D-aspartate (NMDA) 수용체 길항제 [OR = 0.09, 95% CI 0.02 – 0.42], 프로포폴 [OR = 0.07, 95% CI 0.01 – 0.36], 알파2 작용제 [OR = 0.32, 95% CI 0.21 – 0.48], 베타2 작용제 [OR = 0.10, 95% CI 0.03 – 0.30], 펜타닐 예비정주 [OR = 0.33, 95% CI 0.19 – 0.56], 그리고 펜타닐의 저속 주입 [OR = 0.25, 95% CI 0.11 – 0.58]들은 펜타닐 유도성 기침의 발생 감소에 효과적이었다. 반면 아트로핀 [OR = 1.10, 95% CI 0.58 – 2.11]과 벤조다이아제핀 [OR = 2.04, 95% CI 1.33 – 3.13] 계열들은 효과가 없었다. 본 연구에서 리도카인, NMDA 수용체 길항제, 프로포폴, 알파2 작용제, 베타2 작용제, 펜타닐 예비정주, 및 펜타닐의 저속 주입은 펜타닐 유도성 기침 예방에 효과가 있고, 아트로핀과 벤조다이아제핀은 효과가 없음이 밝혀졌다. 펜타닐 저속 주입은 펜타닐 유도성 기침의 예방에 효과가 있으나, 이는 주입 속도에 따라 결과가 달랐다.

ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF FIGURES ⅲ LIST OF TABLES ⅳ Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 2 STATISTICAL ANALYSIS 2 Ⅲ. RESULTS 4 Ⅳ. DISCUSSION 17 Ⅴ. CONCLUSION 20 REFERENCES 21 국문요약 25

Doctor

Advisors/Committee Members: 대학원 의학과, 201225176, 김, 지은.

Subjects/Keywords: Anesthesia; Fentanyl-induced cough; Meta-analysis; Prevention; 마취; 펜타닐 유도성; 기침; 메타분석; 예방

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

김, �. (2014). Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/10941 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

김, 지은. “Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis.” 2014. Thesis, Ajou University. Accessed January 22, 2021. http://repository.ajou.ac.kr/handle/201003/10941 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

김, 지은. “Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis.” 2014. Web. 22 Jan 2021.

Vancouver:

김 �. Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis. [Internet] [Thesis]. Ajou University; 2014. [cited 2021 Jan 22]. Available from: http://repository.ajou.ac.kr/handle/201003/10941 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

김 �. Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis. [Thesis]. Ajou University; 2014. Available from: http://repository.ajou.ac.kr/handle/201003/10941 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

27. Kuhar, Jamie Rose. Mechanisms of Opioid Receptor Desensitization.

Degree: PhD, 2015, University of Washington

URL: http://hdl.handle.net/1773/34122

► Agonists targeting MOR are effective analgesics, but their clinical use is hindered by side effects, including tolerance and addiction. KOR agonists also produce analgesia, but… (more)

▼ Agonists targeting MOR are effective analgesics, but their clinical use is hindered by side effects, including tolerance and addiction. KOR agonists also produce analgesia, but clinical use of these compounds has remained minimal due to aversive properties in humans. The µ-opioid receptor (MOR) agonists, morphine and fentanyl, both activate c-Jun N-terminal kinase (JNK), which is required for spinally-mediated morphine acute analgesic tolerance, whereas acute analgesic tolerance to fentanyl is blocked by G protein-coupled receptor kinase 3 (GRK3) gene deletion. Similarly, the κ-opioid receptor (KOR) collateral antagonist, norBNI, stimulates phosphorylation of JNK, and JNK1 is specifically required for norBNI’s long duration of antagonism. The durations of action of a broad range of KOR antagonists, including norBNI, positively correlate with the ability of the antagonist to activate JNK1 (Melief et al., 2011), whereas there is no correlation between duration of antagonist action and drug clearance (Munro et al., 2012). A better understanding of the mechanisms that contribute to opioid receptor desensitization is necessary for the development of improved therapeutics that avoid tolerance. This JNK-mediated mechanism of desensitization is likely to be more broadly applicable across the myriad of other GPCR systems. Additionally, elucidating the circuits responsible for p38-dependent, KOR-mediated aversion will assist with the development of KOR analgesics that avoid classic MOR side effects. Therefore, the goal of my thesis project has been to identify ligand-directed signaling mechanisms that contribute to JNK activation following morphine and fentanyl administration and better understand how JNK activation promotes MOR and KOR desensitization. Additionally, this thesis describes efforts to identify G biased KOR compounds with a reduced potential to cause dysphoria. Ultimately, this work provides a deeper understanding of opioid receptor signaling and can provide the basis for future therapeutic development targeting this receptor system. Advisors/Committee Members: Chavkin, Charles (advisor).

Subjects/Keywords: Arrestin; c-Jun N-terminal kinase; Fentanyl; Morphine; Opioid; p38; Pharmacology; pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuhar, J. R. (2015). Mechanisms of Opioid Receptor Desensitization. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/34122

Chicago Manual of Style (16^th Edition):

Kuhar, Jamie Rose. “Mechanisms of Opioid Receptor Desensitization.” 2015. Doctoral Dissertation, University of Washington. Accessed January 22, 2021. http://hdl.handle.net/1773/34122.

MLA Handbook (7^th Edition):

Kuhar, Jamie Rose. “Mechanisms of Opioid Receptor Desensitization.” 2015. Web. 22 Jan 2021.

Vancouver:

Kuhar JR. Mechanisms of Opioid Receptor Desensitization. [Internet] [Doctoral dissertation]. University of Washington; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1773/34122.

Council of Science Editors:

Kuhar JR. Mechanisms of Opioid Receptor Desensitization. [Doctoral Dissertation]. University of Washington; 2015. Available from: http://hdl.handle.net/1773/34122

University of Kentucky

28. Malone, Samantha G. ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS.

Degree: 2020, University of Kentucky

URL: https://uknowledge.uky.edu/psychology_etds/183

► Escalation of intake and craving are two DSM-5 hallmark symptoms of opioid use disorder (OUD). Objectives: This study determined if escalation measured by long access… (more)

Subjects/Keywords: Escalation; Sex; Reinstatement; Cue; Yohimbine; Fentanyl; Behavior and Behavior Mechanisms; Substance Abuse and Addiction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Malone, S. G. (2020). ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/psychology_etds/183

Chicago Manual of Style (16^th Edition):

Malone, Samantha G. “ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS.” 2020. Masters Thesis, University of Kentucky. Accessed January 22, 2021. https://uknowledge.uky.edu/psychology_etds/183.

MLA Handbook (7^th Edition):

Malone, Samantha G. “ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS.” 2020. Web. 22 Jan 2021.

Vancouver:

Malone SG. ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS. [Internet] [Masters thesis]. University of Kentucky; 2020. [cited 2021 Jan 22]. Available from: https://uknowledge.uky.edu/psychology_etds/183.

Council of Science Editors:

Malone SG. ESCALATION AND REINSTATEMENT OF FENTANYL SELF-ADMINISTRATION IN MALE AND FEMALE RATS. [Masters Thesis]. University of Kentucky; 2020. Available from: https://uknowledge.uky.edu/psychology_etds/183

29. Maurya, Abhijeet. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.

Degree: PhD, Pharmaceutics and Drug Delivery, 2019, University of Mississippi

URL: https://egrove.olemiss.edu/etd/1635

► Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the… (more)

▼ Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the skin can be attributed to its unique macromolecular organization and morphology. As a route for drug administration, skin presents a large surface area and can be used for both systemic and localized targeted drug delivery applications offering several advantages over conventional drug therapy; avoidance of first pass metabolism, patient compliance, sustained or controlled delivery for an extended period, to name a few. However, the organized structure of the skin, since intended to prevent entry of adverse chemicals, poses a formidable challenge to molecular transport. From a drug delivery perspective, skin is different from GIT in anatomy and functionality, the former being more permeable to drug molecules. Through various peer reviewed research on the drug transport kinetics through skin, it has been realized that the primary barrier to cutaneous drug transport resides in the Stratum Corneum (SC), the uppermost layer of the skin. The 15-20 μm thick lipophilic, torturous morphology of the SC resembles a brick and mortar structure and imposes a limitation on percutaneous drug transport with only a few molecules having the prerequisite physicochemical characteristics to permeate the intact SC. Thus, drug penetration and subsequent diffusion across the SC is a passive process leading to constraints on the amount of drug that is deliverable to achieve the desired therapeutic effect. To increase the number of candidates for cutaneous delivery and to attain appropriate dose levels requires application of certain enhancement strategies. These approaches employ different mechanisms; (i) an external driving force by iontophoresis (ii) reversible modulation of the SC barrier function by chemical penetration enhancers (iii) creating “easy access” transport channels by microneedles. Nevertheless, a thorough understanding of the molecular transport process across the skin is requisite before formulation strategies could be employed to deliver drugs across the skin in a therapeutically pertinent time-frame. The research presented in this dissertation addresses the knowledge gap that pertains to percutaneous drug absorption by investigating the transport of drug molecules into the skin after a short-term exposure (5 minutes) to aqueous and ethanolic drug solution. Further, the research demonstrates the effect of chemical & physical enhancement approaches: chemical penetration enhancers and microneedles on skin permeability to drug molecules. Advisors/Committee Members: S. Narasimha Murthy, Seongbong Jo, N. P. Dhammika Nanayakkara.

Subjects/Keywords: Convective Transport; Fentanyl; Microneedles; Penetration enhancer; Topical; Transdermal; Pharmacy and Pharmaceutical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maurya, A. (2019). Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/1635

Chicago Manual of Style (16^th Edition):

Maurya, Abhijeet. “Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.” 2019. Doctoral Dissertation, University of Mississippi. Accessed January 22, 2021. https://egrove.olemiss.edu/etd/1635.

MLA Handbook (7^th Edition):

Maurya, Abhijeet. “Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules.” 2019. Web. 22 Jan 2021.

Vancouver:

Maurya A. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. [Internet] [Doctoral dissertation]. University of Mississippi; 2019. [cited 2021 Jan 22]. Available from: https://egrove.olemiss.edu/etd/1635.

Council of Science Editors:

Maurya A. Effect of Solvent Interaction & Soluble Microneedles on Skin Permeability to Drug Molecules. [Doctoral Dissertation]. University of Mississippi; 2019. Available from: https://egrove.olemiss.edu/etd/1635

The Ohio State University

30. Lovasz, Michael F. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.

Degree: MS, Veterinary Clinical Sciences, 2016, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

► The objective of the study reported here was to determine pharmacokinetics and pharmacodynamics of fentanyl in alpacas after intravenous (IV) and transdermal (TD) administration.Fentanyl was… (more)

Subjects/Keywords: Veterinary Services; Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration

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APA (6^th Edition):

Lovasz, M. F. (2016). Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

Chicago Manual of Style (16^th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Masters Thesis, The Ohio State University. Accessed January 22, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

MLA Handbook (7^th Edition):

Lovasz, Michael F. “Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration.” 2016. Web. 22 Jan 2021.

Vancouver:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Internet] [Masters thesis]. The Ohio State University; 2016. [cited 2021 Jan 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885.

Council of Science Editors:

Lovasz MF. Pharmacokinetics and Pharmacodynamics of Fentanyl in Alpacas after Intravenous and Transdermal Administration. [Masters Thesis]. The Ohio State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1461173885

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