subject:(Fat cells)

Nelson Mandela Metropolitan University

1. [No author]. The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes.

Degree: Faculty of Science, 2017, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/9208

► CURRENTLY UNDER EMBARGO UNTIL THE 26/4/2019: Type 2 diabetes is a metabolic disorder characterised by inflammation, insulin resistance and the inability of pancreatic β-cells to… (more)

▼ CURRENTLY UNDER EMBARGO UNTIL THE 26/4/2019: Type 2 diabetes is a metabolic disorder characterised by inflammation, insulin resistance and the inability of pancreatic β-cells to secrete enough insulin to produce a physiological effect. Obesity and high levels of triacylglycerol’s are associated with the development of Type 2 diabetes. Adipose tissue is an active endocrine organ that secretes various protein and peptide hormones, known as adipokines, which mediate important metabolic functions. In an insulin resistant and hyperglycaemic state, levels of anti-inflammatory adipokines, adiponectin, are reduced, whereas levels of pro-inflammatory cytokines, interleukin-6 and interleukin-1β, are elevated; this results in a shift from an anti- to a pro-inflammatory state that is accompanied by dysfunction and apoptosis of the pancreatic β-cells. Cannabis sativa L. has been traditionally used as an anti-inflammatory agent in Southern Africa, specifically treating snakebites, fever and malaria. Δ9-tetrahydrocannabinol is the main psychoactive compound derived from C. sativa, whereas the other major cannabinoids, cannabinol and cannabidiol, have shown anti-inflammatory and sedative properties respectively. Marrubiin is a compound derived from the plant Leonotis leonurus L. and has been traditionally used as an anti-inflammatory and anti-diabetic agent. To determine the effects of these compounds in a hyperglycaemic state, pre- and differentiated mouse adipocytes (3T3-L1 cells) were exposed for seven and fourteen days to the following treatments: Δ9-tetrahydrocannabinol, cannabidiol, cannabinol, marrubiin, anandamide (an endogenous endocannabinoid) and cannabis extract, individually and in combination, under normal glucose and hyperglycaemic conditions. Levels of adiponectin, interleukin-6, leptin, tumour-necrosis factor-α and interleukin-1β were quantified using mouse enzyme-linked immunosorbent assay kits and Oil Red O staining was carried out to determine lipid distribution and lipid droplet characteristics. Results indicate that various cannabinoids, in combination, mediate an anti-inflammatory effect by decreasing the expression of various pro-inflammatory cytokines, which may have allowed for a shift from a pro- to an anti-inflammatory state by these compounds, and may also contribute to the reduction of lipid, which may be used as a supplementary option to current diabetic treatment regimes.

Subjects/Keywords: Terpenes; Cytokines; Fat cells

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APA (6^th Edition):

author], [. (2017). The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/9208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes.” 2017. Thesis, Nelson Mandela Metropolitan University. Accessed February 28, 2021. http://hdl.handle.net/10948/9208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes.” 2017. Web. 28 Feb 2021.

Vancouver:

author] [. The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10948/9208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. The effects of terpenoids on the expression and function of cytokines and adipokines in pre-adipocytes and differentiated adipocytes. [Thesis]. Nelson Mandela Metropolitan University; 2017. Available from: http://hdl.handle.net/10948/9208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

2. Chen, Chu-liang, 1961-. Regulation of 3T3-L1 preadipocyte differentiation in culture.

Degree: PhD, Animal Science, 1996, Oregon State University

URL: http://hdl.handle.net/1957/34190

Subjects/Keywords: Fat cells

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APA (6^th Edition):

Chen, Chu-liang, 1. (1996). Regulation of 3T3-L1 preadipocyte differentiation in culture. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/34190

Chicago Manual of Style (16^th Edition):

Chen, Chu-liang, 1961-. “Regulation of 3T3-L1 preadipocyte differentiation in culture.” 1996. Doctoral Dissertation, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/34190.

MLA Handbook (7^th Edition):

Chen, Chu-liang, 1961-. “Regulation of 3T3-L1 preadipocyte differentiation in culture.” 1996. Web. 28 Feb 2021.

Vancouver:

Chen, Chu-liang 1. Regulation of 3T3-L1 preadipocyte differentiation in culture. [Internet] [Doctoral dissertation]. Oregon State University; 1996. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/34190.

Council of Science Editors:

Chen, Chu-liang 1. Regulation of 3T3-L1 preadipocyte differentiation in culture. [Doctoral Dissertation]. Oregon State University; 1996. Available from: http://hdl.handle.net/1957/34190

Oregon State University

3. Vergin, Kevin L. Characterization of a cDNA encoding a procine adipocyte membrane protein.

Degree: MS, Animal Science, 1997, Oregon State University

URL: http://hdl.handle.net/1957/34266

► In recent years, the general public has recognized the dangers of a high fat diet and are demanding meat with lower fat content. This demand… (more)

Subjects/Keywords: Fat cells

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APA (6^th Edition):

Vergin, K. L. (1997). Characterization of a cDNA encoding a procine adipocyte membrane protein. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/34266

Chicago Manual of Style (16^th Edition):

Vergin, Kevin L. “Characterization of a cDNA encoding a procine adipocyte membrane protein.” 1997. Masters Thesis, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/34266.

MLA Handbook (7^th Edition):

Vergin, Kevin L. “Characterization of a cDNA encoding a procine adipocyte membrane protein.” 1997. Web. 28 Feb 2021.

Vancouver:

Vergin KL. Characterization of a cDNA encoding a procine adipocyte membrane protein. [Internet] [Masters thesis]. Oregon State University; 1997. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/34266.

Council of Science Editors:

Vergin KL. Characterization of a cDNA encoding a procine adipocyte membrane protein. [Masters Thesis]. Oregon State University; 1997. Available from: http://hdl.handle.net/1957/34266

University of North Carolina – Greensboro

4. Stall, Richard Jr. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.

Degree: 2012, University of North Carolina – Greensboro

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8889

► Insulin stimulated glucose uptake in adipocytes requires the co-localization of myosin IIA (myoIIA) and glucose transporter 4 (GLUT4) at the plasma membrane. Our previous studies… (more)

Subjects/Keywords: Insulin; Glucose; Fat cells

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APA (6^th Edition):

Stall, R. J. (2012). Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. (Masters Thesis). University of North Carolina – Greensboro. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8889

Chicago Manual of Style (16^th Edition):

Stall, Richard Jr. “Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.” 2012. Masters Thesis, University of North Carolina – Greensboro. Accessed February 28, 2021. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8889.

MLA Handbook (7^th Edition):

Stall, Richard Jr. “Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.” 2012. Web. 28 Feb 2021.

Vancouver:

Stall RJ. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. [Internet] [Masters thesis]. University of North Carolina – Greensboro; 2012. [cited 2021 Feb 28]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8889.

Council of Science Editors:

Stall RJ. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. [Masters Thesis]. University of North Carolina – Greensboro; 2012. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8889

5. NC DOCKS at The University of North Carolina at Greensboro; Stall, Richard. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.

Degree: 2012, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/StallJr_uncg_0154M_11010.pdf

► Insulin stimulated glucose uptake in adipocytes requires the co-localization of myosin IIA (myoIIA) and glucose transporter 4 (GLUT4) at the plasma membrane. Our previous studies… (more)

Subjects/Keywords: Insulin; Glucose; Fat cells

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Stall, R. (2012). Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/StallJr_uncg_0154M_11010.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Stall, Richard. “Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.” 2012. Thesis, NC Docks. Accessed February 28, 2021. http://libres.uncg.edu/ir/uncg/f/StallJr_uncg_0154M_11010.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Stall, Richard. “Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes.” 2012. Web. 28 Feb 2021.

Vancouver:

NC DOCKS at The University of North Carolina at Greensboro; Stall R. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. [Internet] [Thesis]. NC Docks; 2012. [cited 2021 Feb 28]. Available from: http://libres.uncg.edu/ir/uncg/f/StallJr_uncg_0154M_11010.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NC DOCKS at The University of North Carolina at Greensboro; Stall R. Investigation of the interaction between myosin IIA and filamentous actin during insulin stimulated glucose uptake in 3T3-L1 adipocytes. [Thesis]. NC Docks; 2012. Available from: http://libres.uncg.edu/ir/uncg/f/StallJr_uncg_0154M_11010.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

6. Long, Yanyang LIFS. E2F4 suppresses Prdm16 gene expression in white fat progenitor cells.

Degree: 2017, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-91188 ; https://doi.org/10.14711/thesis-991012564863503412 ; http://repository.ust.hk/ir/bitstream/1783.1-91188/1/th_redirect.html

► Mammals are known to have three types of fat tissues: white, beige, and brown fat. While white adipose tissues (WAT) mainly function to store energy,… (more)

Subjects/Keywords: Gene expression ; Fat cells ; Stem cells

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APA (6^th Edition):

Long, Y. L. (2017). E2F4 suppresses Prdm16 gene expression in white fat progenitor cells. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-91188 ; https://doi.org/10.14711/thesis-991012564863503412 ; http://repository.ust.hk/ir/bitstream/1783.1-91188/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Long, Yanyang LIFS. “E2F4 suppresses Prdm16 gene expression in white fat progenitor cells.” 2017. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-91188 ; https://doi.org/10.14711/thesis-991012564863503412 ; http://repository.ust.hk/ir/bitstream/1783.1-91188/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Long, Yanyang LIFS. “E2F4 suppresses Prdm16 gene expression in white fat progenitor cells.” 2017. Web. 28 Feb 2021.

Vancouver:

Long YL. E2F4 suppresses Prdm16 gene expression in white fat progenitor cells. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2017. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-91188 ; https://doi.org/10.14711/thesis-991012564863503412 ; http://repository.ust.hk/ir/bitstream/1783.1-91188/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Long YL. E2F4 suppresses Prdm16 gene expression in white fat progenitor cells. [Thesis]. Hong Kong University of Science and Technology; 2017. Available from: http://repository.ust.hk/ir/Record/1783.1-91188 ; https://doi.org/10.14711/thesis-991012564863503412 ; http://repository.ust.hk/ir/bitstream/1783.1-91188/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. 海田, 浩治. Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000095/

►

Despite the advances in stem cell biology, there are few effective techniques to promote the osteogenic differentiation of human primary dedifferentiated fat (DFAT) cells. We… (more)

Subjects/Keywords: Human Dedifferentiated Fat Cells; Catechin; Osteogenic

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APA (6^th Edition):

海田, �. (2016). Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000095/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

海田, 浩治. “Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed February 28, 2021. http://id.nii.ac.jp/1392/00000095/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

海田, 浩治. “Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用.” 2016. Web. 28 Feb 2021.

Vancouver:

海田 �. Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Feb 28]. Available from: http://id.nii.ac.jp/1392/00000095/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

海田 �. Application of Green Tea Catechin for Inducing the Osteogenic Differentiation of Human Dedifferentiated Fat Cells in Vitro : ヒト脱分化脂肪細胞の骨芽細胞分化誘導にむけたin vitroでの緑茶カテキンの応用. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000095/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

8. Cao, Zhe LIFS. Molecular mechanisms for seipin targeting in caenorhabditis elegans.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-95091 ; https://doi.org/10.14711/thesis-b1626242 ; http://repository.ust.hk/ir/bitstream/1783.1-95091/1/th_redirect.html

► Lipid droplets (LDs) are organelles conserved for synthesizing, storing and supplying lipid in eukaryotes. They consist of a neutral lipid core that is surrounded by… (more)

Subjects/Keywords: Lipids ; Morphology ; Fat cells ; Caenorhabditis elegans

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APA (6^th Edition):

Cao, Z. L. (2016). Molecular mechanisms for seipin targeting in caenorhabditis elegans. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-95091 ; https://doi.org/10.14711/thesis-b1626242 ; http://repository.ust.hk/ir/bitstream/1783.1-95091/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cao, Zhe LIFS. “Molecular mechanisms for seipin targeting in caenorhabditis elegans.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-95091 ; https://doi.org/10.14711/thesis-b1626242 ; http://repository.ust.hk/ir/bitstream/1783.1-95091/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cao, Zhe LIFS. “Molecular mechanisms for seipin targeting in caenorhabditis elegans.” 2016. Web. 28 Feb 2021.

Vancouver:

Cao ZL. Molecular mechanisms for seipin targeting in caenorhabditis elegans. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-95091 ; https://doi.org/10.14711/thesis-b1626242 ; http://repository.ust.hk/ir/bitstream/1783.1-95091/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cao ZL. Molecular mechanisms for seipin targeting in caenorhabditis elegans. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-95091 ; https://doi.org/10.14711/thesis-b1626242 ; http://repository.ust.hk/ir/bitstream/1783.1-95091/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

9. Sluka, Robert Daniel. The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes.

Degree: MS, Department of Fisheries and Wildlife, 1991, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:22988

Subjects/Keywords: Calcium; Fat cells

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APA (6^th Edition):

Sluka, R. D. (1991). The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:22988

Chicago Manual of Style (16^th Edition):

Sluka, Robert Daniel. “The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes.” 1991. Masters Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:22988.

MLA Handbook (7^th Edition):

Sluka, Robert Daniel. “The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes.” 1991. Web. 28 Feb 2021.

Vancouver:

Sluka RD. The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes. [Internet] [Masters thesis]. Michigan State University; 1991. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:22988.

Council of Science Editors:

Sluka RD. The effects of spring climate, spawner abundance, and cannibalism on the abundance of rainbow smelt (Osmerus Mordax) at two sites in the upper Great Lakes. [Masters Thesis]. Michigan State University; 1991. Available from: http://etd.lib.msu.edu/islandora/object/etd:22988

Michigan State University

10. Slusar Grabski, Sharon. Intracellular available calcium determination in adipocytes using Indo-1.

Degree: MS, Department of Medical Technology, 1991, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:23005

Subjects/Keywords: Calcium; Fat cells

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Slusar Grabski, S. (1991). Intracellular available calcium determination in adipocytes using Indo-1. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:23005

Chicago Manual of Style (16^th Edition):

Slusar Grabski, Sharon. “Intracellular available calcium determination in adipocytes using Indo-1.” 1991. Masters Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:23005.

MLA Handbook (7^th Edition):

Slusar Grabski, Sharon. “Intracellular available calcium determination in adipocytes using Indo-1.” 1991. Web. 28 Feb 2021.

Vancouver:

Slusar Grabski S. Intracellular available calcium determination in adipocytes using Indo-1. [Internet] [Masters thesis]. Michigan State University; 1991. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:23005.

Council of Science Editors:

Slusar Grabski S. Intracellular available calcium determination in adipocytes using Indo-1. [Masters Thesis]. Michigan State University; 1991. Available from: http://etd.lib.msu.edu/islandora/object/etd:23005

11. NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh, Jonah B. The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes.

Degree: 2018, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/Nikouyeh_uncg_0154M_12580.pdf

► Aberrant insulin signaling results in an impaired ability to clear glucose from the bloodstream, which progresses to type II diabetes mellitus once insulin stimulation no… (more)

Subjects/Keywords: Myosin; Fat cells; Exocytosis; Glucose; Diabetes

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APA (6^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh, J. B. (2018). The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/Nikouyeh_uncg_0154M_12580.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh, Jonah B. “The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes.” 2018. Thesis, NC Docks. Accessed February 28, 2021. http://libres.uncg.edu/ir/uncg/f/Nikouyeh_uncg_0154M_12580.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh, Jonah B. “The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes.” 2018. Web. 28 Feb 2021.

Vancouver:

NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh JB. The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes. [Internet] [Thesis]. NC Docks; 2018. [cited 2021 Feb 28]. Available from: http://libres.uncg.edu/ir/uncg/f/Nikouyeh_uncg_0154M_12580.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NC DOCKS at The University of North Carolina at Greensboro; Nikouyeh JB. The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes. [Thesis]. NC Docks; 2018. Available from: http://libres.uncg.edu/ir/uncg/f/Nikouyeh_uncg_0154M_12580.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

12. Thelen, Kyan. Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue.

Degree: 2017, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:6827

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Thesis M.S. Michigan State University. Comparative Medicine and Integrative Biology 2017

"Adipose tissue is an important multi-depot and multi-function organ. Each depot exhibits a unique… (more)

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Thesis M.S. Michigan State University. Comparative Medicine and Integrative Biology 2017

"Adipose tissue is an important multi-depot and multi-function organ. Each depot exhibits a unique phenotype relative to its anatomical location and specific function. Among adipose depots, the perivascular adipose tissue (PVAT) is a major regulator of blood vessel function due to its proximity to the vasculature and its ability to secrete vasoactive molecules. The comprehensive study of PVAT biology requires in vivo, ex vivo, and reductionist approaches. Adipogenic models of PVAT, where preadipocytes from these tissues are induced to differentiate into adipocytes, are an important reductionist model that can be used to study the perivascular adipocyte. However, the development of PVAT cellular models is challenging because the standardized pharmacological induction of adipogenesis does not have the same efficacy when used across multiple PVAT depots. Different research laboratories have attempted to increase the efficiency of the standard pharmacological adipogenesis induction by pairing it with alternative approaches to cell culture to improve adipogenesis simultaneously such as polymer structures, matrices, and co-cultures. These have been effective in differentiating adipocytes from other visceral adipocytes, but not yet reported to be used in PVAT adipocytes. Another difficulty in adipogenic modeling is that preadipocyte populations in each depot have different adipogenic potential. As not all fibroblast like cells in adipose will differentiate into adipocytes, adipogenic capacity is determined by a population of cells committed to differentiation called adipocyte progenitor cells (APC). These cells, that express a unique profile of specific surface markers, must be isolated from the stromal vascular fraction (SVF) of the adipose. The goal of this thesis was to develop alternative methods to improve the efficiency of current models of adipogenesis in PVAT. We first adapted the use of magnetic activate cell sorting (MCS) to isolate adipocyte progenitor cells (APC). These adipocyte precursors must then be cultured to initiate adipogenesis in order to study mature adipocytes that are phenotypically and functionally similar to primary adipocytes of the same depot. Next, we developed a co-culture method that improved the adipogenesis efficiency and reduced the time required to induce differentiation in a cell culture model of PVAT. Our work provides a method to isolate APC from PVATs and a method using co-culture to differentiate PVAT preadipocytes, both of which are efficient in creating a more accurate depot-specific PVAT model of adipogenesis." – Abstract.

Online resource;

Advisors/Committee Members: Contreras, G. Andres, Bernard, Jamie J, Moeser, Adam J, Watts, Stephanie W.

Subjects/Keywords: Adipose tissues; Fat cells; Stem cells; Biology; Perivasular adipose tissues; Adipogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thelen, K. (2017). Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:6827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thelen, Kyan. “Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue.” 2017. Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:6827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thelen, Kyan. “Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue.” 2017. Web. 28 Feb 2021.

Vancouver:

Thelen K. Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue. [Internet] [Thesis]. Michigan State University; 2017. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:6827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thelen K. Alternatives for improving the adipogenic potential in cellular models of perivascular adipose tissue. [Thesis]. Michigan State University; 2017. Available from: http://etd.lib.msu.edu/islandora/object/etd:6827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

13. An, Yitai LIFS. A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes.

Degree: 2017, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-105618 ; https://doi.org/10.14711/thesis-991012563964603412 ; http://repository.ust.hk/ir/bitstream/1783.1-105618/1/th_redirect.html

► During mouse embryo development, Pax7⁺/Myf5⁺ progenitor cells give rise to both muscle progenitor cells (MPC) and brown adipocytes (BA). The underlying mechanisms for the cell… (more)

Subjects/Keywords: Stem cells ; Fat cells ; Muscle proteins ; Muscles ; Growth

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

An, Y. L. (2017). A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-105618 ; https://doi.org/10.14711/thesis-991012563964603412 ; http://repository.ust.hk/ir/bitstream/1783.1-105618/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

An, Yitai LIFS. “A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes.” 2017. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-105618 ; https://doi.org/10.14711/thesis-991012563964603412 ; http://repository.ust.hk/ir/bitstream/1783.1-105618/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

An, Yitai LIFS. “A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes.” 2017. Web. 28 Feb 2021.

Vancouver:

An YL. A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2017. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-105618 ; https://doi.org/10.14711/thesis-991012563964603412 ; http://repository.ust.hk/ir/bitstream/1783.1-105618/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

An YL. A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes. [Thesis]. Hong Kong University of Science and Technology; 2017. Available from: http://repository.ust.hk/ir/Record/1783.1-105618 ; https://doi.org/10.14711/thesis-991012563964603412 ; http://repository.ust.hk/ir/bitstream/1783.1-105618/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Macquarie University

14. Wongtrakul-Kish, Katherine. Glycobiology of adipose-derived stem cell differentiation.

Degree: 2016, Macquarie University

URL: http://hdl.handle.net/1959.14/1128672

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Theoretical thesis.

1. Introduction – 2.Evaluating adipose-derived stem cell differentiation in vitro – 3. Characterisation and comparison of N- and O-linked glycosylation during in vivo… (more)

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Theoretical thesis.

1. Introduction – 2.Evaluating adipose-derived stem cell differentiation in vitro – 3. Characterisation and comparison of N- and O-linked glycosylation during in vivo and in vitro adipogenic differentiation – 4.Characterisation and comparison of the plasma membrane proteome during in vivo and in vitro adipogenic differentiation – 5. Adipose-derived stem cell differentiation: targeting the cell membrane protein glycosylation – 6. General discussion.

Human adipose tissue is a major source of mesenchymal stem cells, with numbers exceeding those in bone marrow and blood. These stem cells are referred to as adipose-derived stem cells (ADSCs) and have the ability to differentiate into different cell types. In vitro, ADSCs can be made to differentiate into the mesenchymal lineages of adipocytes, osteoblasts and chondrocytes, while in vivo, ADSCs become pre-adipocytes before further differentiating into mature adipocytes. Protein glycosylation has been shown to change in stem cell differentiation, and while ADSCs have been acknowledged for their therapeutic potential, the investigation of protein glycosylation changes during ADSC adipogenic differentiation has not been reported.

First, adipogenic differentiation of ADSCs in vitro was optimised and evaluated by measuring the expression levels of established gene-markers and staining of the accumulated lipid in differentiated cells using Oil Red O. These results confirmed the cells had entered the adipogenic lineage and shared some characteristics with, but did not entirely mirror native, in vivo produced adipocytes.

ADSCs, in vitro differentiated ADSCs and in vivo native mature adipocytes harvested from the same patients were used to investigate the membrane protein N- and O-linked glycosylation of adipogenesis. Using porous graphitised carbon LC coupled with negative ion ESI-MS/MS, a total of 138 glycan structures carried by the membrane proteins were characterised across the three cell types. Bisecting GlcNAc type N-linked structures were detected at a high level (32.1 % of total glycans) in mature adipocytes with some appearing in the differentiating ADSCs (1.9 %), while overall, ADSCs and their in vitro differentiated progeny showed similar glycosylation expression profiles. This finding was further correlated by increased mRNA expression of the MGAT3 gene responsible for the enzyme synthesis of this glycan structure type in both the in vivo and in vitro differentiated ADSCs.

The same cell types (ADSCs, differentiated ADSCs and mature adipocytes) were characterised for their membrane proteome using label-free quantitative shotgun proteomics analysis. Many protein differences were identified between the three cell types, with, importantly, adipocyte-specific proteins found to be up-regulated in both mature adipocytes and differentiating ADSCs. Mitochondrial and lipid-related processes were also up-regulated in both adipogenic cell products, whereas epigenetic-related proteins and processes were found to be up-regulated in in…

Advisors/Committee Members: Macquarie University. Department of Chemistry and Biomolecular Sciences.

Subjects/Keywords: Stem cells – Research; Fat cells – Research; adipogenesis; stem cell; glycomics; proteomics

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wongtrakul-Kish, K. (2016). Glycobiology of adipose-derived stem cell differentiation. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1128672

Chicago Manual of Style (16^th Edition):

Wongtrakul-Kish, Katherine. “Glycobiology of adipose-derived stem cell differentiation.” 2016. Doctoral Dissertation, Macquarie University. Accessed February 28, 2021. http://hdl.handle.net/1959.14/1128672.

MLA Handbook (7^th Edition):

Wongtrakul-Kish, Katherine. “Glycobiology of adipose-derived stem cell differentiation.” 2016. Web. 28 Feb 2021.

Vancouver:

Wongtrakul-Kish K. Glycobiology of adipose-derived stem cell differentiation. [Internet] [Doctoral dissertation]. Macquarie University; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1959.14/1128672.

Council of Science Editors:

Wongtrakul-Kish K. Glycobiology of adipose-derived stem cell differentiation. [Doctoral Dissertation]. Macquarie University; 2016. Available from: http://hdl.handle.net/1959.14/1128672

Macquarie University

15. Varinli, Hilal. The epigenome of human adipocytes.

Degree: 2017, Macquarie University

URL: http://hdl.handle.net/1959.14/1277615

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Thesis by publication.

The increasing incidence of obesity is a major public health crisis worldwide. Obesity is linked to a number of poor health outcomes… (more)

▼

Thesis by publication.

The increasing incidence of obesity is a major public health crisis worldwide. Obesity is linked to a number of poor health outcomes such as Type 2 Diabetes (T2D), cardiovascular disease and cancer. Thus, the obesity epidemic threatens to lower life expectancy and reduce health-related life quality of current and future generations. It places a significant economic burden on healthcare systems. A better understanding of the factors that contribute to the development of obesity and how fat tissue contributes to these adverse effects are essential to improve prevention and treatment strategies. In this thesis, I examined the potential role of epigenetics as a mediator of gene-environment interactions in manifesting functional changes in fat cells, and whether these processes could be targeted to prevent and treat obesity. Firstly, I investigated whether exposure of human fat cells (adipocytes) to high glucose induces physiological and metabolic changes (Chapter 1). I then examined whether nuclear processes such as the genomic landscape of transcriptional and epigenetic regulation were involved in the manifestation of these changes. I used genome wide microarray analysis of both DNA methylation and transcription during the differentiation of human adipocytes in vitro. I showed that adipocytes grown in high glucose had significant changes in gene expression, particularly in mitochondrial and oxidative stress pathways, and that some of these changes were associated with epigenetic changes. Secondly, increased lipid storage in adipocytes is a major contributor to the increase in fat in humans, and these lipids are stored as lipid droplets within adipocytes (Chapter 2). I developed a novel label-free lipid droplet quantification technique (LipiD-QuanT) to monitor fat accumulation in live adipocytes. The current techniques used to quantify fat accumulation during in vitro studies are based on either enzymatic digest or lipophilic staining. However, LipiD-Quant is label free and applicable to live cells. Additionally, I demonstrated the application of LipiD-QuanT to measure the effect of four potential pro- or anti-obesogenic iv substances during human pre-adipocyte differentiation: Docosahexaenoic acid (DHA), rosiglitazone, D-glucose and Zinc oxide (ZnO) nanoparticles. Thirdly, since I began my PhD, epigenetics analysis methods have continued to improve. While most common methods target locations of the genome where methylation occurs densely, there is growing evidence that methylation in less dense genomic locations is equally, if not more important. Hence, I developed a new genome wide reduced methylome method (COBRA-Seq) (Chapter 3). This method enriches methylated DNA fractions by digesting the genomic DNA with restriction enzymes that recognize potential methylation sites after bisulfite conversion. The genomic complexity is further reduced by removing DNA fragments without the enzyme recognition site using streptavidin coated magnetic beads. COBRA-seq samples the genome proportionally…

Advisors/Committee Members: Macquarie University. Department of Biological Sciences.

Subjects/Keywords: Fat cells – Research; Epigenetics – Research; epigenetics; human obesity; adipocytes; transcriptome; methylation; glucose; fat

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varinli, H. (2017). The epigenome of human adipocytes. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1277615

Chicago Manual of Style (16^th Edition):

Varinli, Hilal. “The epigenome of human adipocytes.” 2017. Doctoral Dissertation, Macquarie University. Accessed February 28, 2021. http://hdl.handle.net/1959.14/1277615.

MLA Handbook (7^th Edition):

Varinli, Hilal. “The epigenome of human adipocytes.” 2017. Web. 28 Feb 2021.

Vancouver:

Varinli H. The epigenome of human adipocytes. [Internet] [Doctoral dissertation]. Macquarie University; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1959.14/1277615.

Council of Science Editors:

Varinli H. The epigenome of human adipocytes. [Doctoral Dissertation]. Macquarie University; 2017. Available from: http://hdl.handle.net/1959.14/1277615

University of Southern California

16. Gyllenhammer, Lauren Elizabeth. Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults.

Degree: PhD, Integrative Biology of Disease, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/526587/rec/5360

► Obesity affects an estimated 78.6 million adults in the US and 396 million globally, and is associated with type 2 diabetes, cardiovascular disease, non-alcoholic fatty… (more)

▼ Obesity affects an estimated 78.6 million adults in the US and 396 million globally, and is associated with type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and some forms of cancer. The accumulation of body fat routinely leads to an insulin resistant (IR) syndrome and low-grade inflammation, which are both thought to underlie the link between adiposity and disease. There are promising theories on the deposition of fat in non-adipose (ecoptic) sites leading to higher IR and inflammation, however the development of these depots and resulting metabolic implications are unproven, and will be explored in this dissertation. Furthermore, rates of obesity and resulting comorbidities are higher in African American (AA) and Hispanic patients, and different patterns of fat deposition across ethnicities implies divergent causes of IR and disease. Ethnic specific pathways of adipose tissue pathology are also explored in this dissertation, and state of the art immunology techniques are used to define adipose tissue (AT) immune profiles across diverse populations. ❧ Recent cross-sectional studies have implicated the accumulation of hepatic adipose tissue as primary in metabolic risk, however there is limited longitudinal data on the timing and consequences of hepatic accumulation. In this dissertation, we report that hepatic fat fraction (HFF) and pancreatic fat fraction (PFF) significantly increased over 2 years in late- and post-pubertal growth, whereas children earlier in their sexual development tended to accumulate subcutaneous abdominal adipose tissue (SAAT) and defend against ectopic fat development. The 2-year increase in HFF and visceral adipose tissue (VAT) associated with metabolic impairment, whereas the expansion of SAAT associated with metabolic improvement/protection. While both HFF and VAT predicted metabolic risk markers, change in HFF was the only depot to predict important clinical markers for type 2 diabetes, fasting glucose and HbA1c. ❧ The first project highlights the importance of adipose quantity and location for assessing metabolic risk, however the activity or functional quality of AT may be even more important in understanding disease risk and AT pathophysiology. In the second project of this dissertation we report that the SAAT expression levels of the enzyme that activates the hormone cortisol, 11-beta hydroxysteroid dehydrogenase-1 (11βHSD1), differentially predicted metabolic risk in an overweight population of AA and Hispanic young adults. While the level of SAAT quantity was matched between the two groups, higher SAAT 11βHSD1 expression predicted a worsening of IR and beta-cell function in AAs, and thus the activity of SAAT rather than quantity revealed a pattern of ethnic specific risk. The SAAT expression level of 11βHSD1 also associated with increased HFF in both ethnicities, further supporting the evidence for 11βHSD1 and intra-cellular cortisol levels in type 2 diabetes disease pathology. ❧ In the third project, we explored the exciting field of immunometabolism and… Advisors/Committee Members: Goran, Michael (Committee Chair), Allayee, Hooman (Committee Member), Akbari, Omid (Committee Member), Watanabe, Richard M. (Committee Member).

Subjects/Keywords: adipose tissue; ectopic fat; type 2 diabetes; liver fat; visceral fat; inflammation; cortisol; T regulatory cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gyllenhammer, L. E. (2015). Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/526587/rec/5360

Chicago Manual of Style (16^th Edition):

Gyllenhammer, Lauren Elizabeth. “Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults.” 2015. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/526587/rec/5360.

MLA Handbook (7^th Edition):

Gyllenhammer, Lauren Elizabeth. “Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults.” 2015. Web. 28 Feb 2021.

Vancouver:

Gyllenhammer LE. Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults. [Internet] [Doctoral dissertation]. University of Southern California; 2015. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/526587/rec/5360.

Council of Science Editors:

Gyllenhammer LE. Quantity versus quality: how adipose tissue accumulation and immune cell profile associate with risk for type 2 diabetes in minority children and adults. [Doctoral Dissertation]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/526587/rec/5360

Stellenbosch University

17. Bartlett, Cara-Lesley. The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells.

Degree: D.Phil, Medicine, 2017, Stellenbosch University

URL: http://hdl.handle.net/10019.1/101088

► ENGLISH SUMMARY: Diseases resulting from the dysregulation of adipocyte and osteoblast differentiation include diabetes type II and osteoporosis. Both adipocytes and osteoblasts are derived from… (more)

▼ ENGLISH SUMMARY: Diseases resulting from the dysregulation of adipocyte and osteoblast differentiation include diabetes type II and osteoporosis. Both adipocytes and osteoblasts are derived from the same progenitor cell type, known as mesenchymal stromal cells (MSCs), which may also differentiate into cells of several mesenchymal lineages. A more detailed understanding of the mechanisms involved in the differentiation of MSCs would provide valuable insight into the underlying causes of, as well as facilitate the development of improved treatments for, diseases related to MSC differentiation dysregulation. Tissue-nonspecific alkaline phosphatase (TNAP) is highly expressed in several tissues including bone tissue, where it has a well-established role in skeletal mineralisation. In recent years TNAP expression has been reported in adipocytes, and has been identified as identical to the stem cell marker, mesenchymal stem cell antigen-1 (MSCA-1). The above findings indicate that TNAP has diverse roles, and may be one of the factors involved in determining the differentiation pathway of MSCs. Previous studies have found that inhibition of TNAP in the mouse preadipocyte cell line, 3T3-L1 resulted in a decrease in lipid accumulation during in vitro adipogenic differentiation, suggesting that TNAP is involved in adipogenesis. In the present study, rat-derived primary MSCs were isolated from bone marrow (bmMSCs) as well as subcutaneous (scADSCs) and peri-renal visceral adipose (pvADSCs) depots, and differentiated in vitro towards either an adipocytic or osteoblastic phenotype. The expression of TNAP was assessed in rat-derived MSCs undergoing both adipogenic and osteogenic differentiation. TNAP expression levels were highest in bmMSCs, followed by scADSCs and pvADSCs, with higher alkaline phosphatase (ALP) activity observed during adipogenesis compared to osteogenesis in all three MSC types. The addition of the reported TNAP inhibitor, levamisole during osteogenesis prevented mineralisation in all MSC types, but had no significant effect on lipid accumulation during adipogenesis. Other reported inhibitors were also examined; Histidine was not successful in reducing lipid accumulation or mineralisation, while Lhomoarginine was able to significantly reduce lipid accumulation in all MSC types. The inhibitor results were not conclusive due to possible off target effects within the cells. Attempts to inhibit adipogenic differentiation by knockdown of TNAP expression in scADSCs using shRNA were not successful, as indicated by the presence of lipid droplets in cells where TNAP-specific shRNA was present. This study also revealed that ALP activity was localised to the membrane of intracellular lipid droplets characteristic of adipocytes, and that the same TNAP mRNA transcript type which is preferentially expressed in bone tissue is also preferably expressed during adipogenic differentiation of bmMSCs and scADSCs, while expression in pvADSCs was below detectable levels. TNAP isoforms differ from one another due to… Advisors/Committee Members: Ferris, William F., Crowther, Nigel J., Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medicine. General Internal Medicine..

Subjects/Keywords: Tissue non-specific alkaline phosphatase; Mesenchymal stromal cells; Alkaline phosphatase; Fat cells; Adipocytes; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bartlett, C. (2017). The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells. (Doctoral Dissertation). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/101088

Chicago Manual of Style (16^th Edition):

Bartlett, Cara-Lesley. “The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells.” 2017. Doctoral Dissertation, Stellenbosch University. Accessed February 28, 2021. http://hdl.handle.net/10019.1/101088.

MLA Handbook (7^th Edition):

Bartlett, Cara-Lesley. “The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells.” 2017. Web. 28 Feb 2021.

Vancouver:

Bartlett C. The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells. [Internet] [Doctoral dissertation]. Stellenbosch University; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10019.1/101088.

Council of Science Editors:

Bartlett C. The association between tissue non-specific alkaline phosphatase expression and differentiation of mesenchymal stromal cells. [Doctoral Dissertation]. Stellenbosch University; 2017. Available from: http://hdl.handle.net/10019.1/101088

18. 西尾, 謙宏. Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000014/

►

We evaluated the chondrocyte differentiation potential of dedifferentiated fat cells (DFATs) and adipose stem cells (ASCs) from the human buccal fat pad (BFP). We isolated… (more)

Subjects/Keywords: Dedifferentiated fat cells; Adipose stem cells; Ceiling culture; Buccal fat pad; Chondrocyte differentiation; Cartilage tissue engineering; Dedifferentiated fat cells; Adipose stem cells; Ceiling culture; Buccal fat pad; Chondrocyte differentiation; Cartilage tissue engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

西尾, �. (2016). Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000014/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

西尾, 謙宏. “Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed February 28, 2021. http://id.nii.ac.jp/1392/00000014/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

西尾, 謙宏. “Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化.” 2016. Web. 28 Feb 2021.

Vancouver:

西尾 �. Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Feb 28]. Available from: http://id.nii.ac.jp/1392/00000014/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

西尾 �. Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge : アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000014/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

19. Coutinho, Luiz Lehmann. Adrenergic control of lipolysis in porcine adipocytes.

Degree: PhD, Department of Animal Science, 1990, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:21738

Subjects/Keywords: Lipolysis; Swine – Physiology; Fat cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Coutinho, L. L. (1990). Adrenergic control of lipolysis in porcine adipocytes. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:21738

Chicago Manual of Style (16^th Edition):

Coutinho, Luiz Lehmann. “Adrenergic control of lipolysis in porcine adipocytes.” 1990. Doctoral Dissertation, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:21738.

MLA Handbook (7^th Edition):

Coutinho, Luiz Lehmann. “Adrenergic control of lipolysis in porcine adipocytes.” 1990. Web. 28 Feb 2021.

Vancouver:

Coutinho LL. Adrenergic control of lipolysis in porcine adipocytes. [Internet] [Doctoral dissertation]. Michigan State University; 1990. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:21738.

Council of Science Editors:

Coutinho LL. Adrenergic control of lipolysis in porcine adipocytes. [Doctoral Dissertation]. Michigan State University; 1990. Available from: http://etd.lib.msu.edu/islandora/object/etd:21738

University of Toronto

20. Rosenfeld, Robyn. Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster.

Degree: PhD, 2014, University of Toronto

URL: http://hdl.handle.net/1807/98139

►

Fat is a large cadherin that plays a role in both tissue growth and planar cell polarity (PCP). How Fat regulates these cellular processes is… (more)

Subjects/Keywords: Fat; Germ cells; Nuclear membrane; Oogenesis; Spermatogenesis; 0369

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APA (6^th Edition):

Rosenfeld, R. (2014). Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/98139

Chicago Manual of Style (16^th Edition):

Rosenfeld, Robyn. “Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster.” 2014. Doctoral Dissertation, University of Toronto. Accessed February 28, 2021. http://hdl.handle.net/1807/98139.

MLA Handbook (7^th Edition):

Rosenfeld, Robyn. “Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster.” 2014. Web. 28 Feb 2021.

Vancouver:

Rosenfeld R. Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1807/98139.

Council of Science Editors:

Rosenfeld R. Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/98139

Columbia University

21. Flaherty, Stephen. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior.

Degree: 2020, Columbia University

URL: https://doi.org/10.7916/d8-3d4c-f497

► To meet the body’s metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Lipids are also key local regulators of… (more)

Subjects/Keywords: Biology; Lipase; Macrophages; Fat cells; Adipose tissues – Analysis

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APA (6^th Edition):

Flaherty, S. (2020). Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-3d4c-f497

Chicago Manual of Style (16^th Edition):

Flaherty, Stephen. “Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior.” 2020. Doctoral Dissertation, Columbia University. Accessed February 28, 2021. https://doi.org/10.7916/d8-3d4c-f497.

MLA Handbook (7^th Edition):

Flaherty, Stephen. “Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior.” 2020. Web. 28 Feb 2021.

Vancouver:

Flaherty S. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Feb 28]. Available from: https://doi.org/10.7916/d8-3d4c-f497.

Council of Science Editors:

Flaherty S. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-3d4c-f497

Boston University

22. Vo, Hung. Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14388

► B1 B cells have received increasing attention recently due to their newly discovered phagocytic and microbicidal capabilities. Several studies have demonstrated that B1 cells can… (more)

Subjects/Keywords: Immunology; B1 B cells; High fat diet; Macrophages; Obesity; Phagocytosis; Phospholipid

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APA (6^th Edition):

Vo, H. (2014). Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14388

Chicago Manual of Style (16^th Edition):

Vo, Hung. “Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice.” 2014. Masters Thesis, Boston University. Accessed February 28, 2021. http://hdl.handle.net/2144/14388.

MLA Handbook (7^th Edition):

Vo, Hung. “Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice.” 2014. Web. 28 Feb 2021.

Vancouver:

Vo H. Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2144/14388.

Council of Science Editors:

Vo H. Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14388

University of Melbourne

23. Tan, Shaun S. Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/122069

► Background: Autologous fat grafting has emerged as a key technique in soft tissue reconstruction, and is currently utilized for various deformities secondary to burns, chronic… (more)

▼ Background: Autologous fat grafting has emerged as a key technique in soft tissue reconstruction, and is currently utilized for various deformities secondary to burns, chronic wounds, trauma, irradiation injuries and post-oncological resections. Nevertheless, a significant proportion of the transplanted fat fails to survive within the host environment, which may partly be attributed to cell death of its constituents. A process known as cell-assisted transfer is now used clinically to further enhance fat graft retention by adding stromal vascular fraction (SVF), an adipose-derived stem cell (ASC) rich content to lipoaspirate. However, there are certain concerns about cell-assisted lipotransfer especially regarding its oncologic safety and feasibility. Methods: The basis of this project stems from the need for reproducible and predictable clinical outcomes following transplantation of adipose tissue. To this end, the properties of two safe, commercially available and FDA-approved drugs, melatonin and indomethacin were studied. The in-vitro effects of melatonin on human ASCs were investigated through functional and survival assays including oxidative stress and cell-death assays, MTT Assay, monolayer scratch assay, cell membrane integrity assay, a human cytokine array, and a specific TNF-alpha ELISA kit. The in-vitro effects of indomethacin and melatonin on human ASC adipogenesis were investigated through a lipid (Oil Red O) staining kit as well as reverse transcription polymerase chain reaction (RT-PCR) to determine RNA expression of key adipogenic genes. The effects of melatonin-treated autologous fat grafts injected into the dorsums were tested in-vivo with a murine model, and its weights and volumes were assessed at three time points of two, four and twelve weeks. Hematoxylin and eosin staining, perilipin and CD31 immunostaining were performed with morphometric analysis of adipose tissue and vascularization. Results: The in-vitro results indicate that melatonin significantly protects human ASCs from hydrogen peroxide induced cell-death in a dose-dependent fashion. Addition of melatonin to ASCs improved cell-viability, promoted cell migration and preserved membrane integrity as compared to controls. In addition, it induced a potent anti-inflammatory response by down-regulating acute inflammatory cytokines particularly TNF-alpha but melatonin itself did not exert an adipogenic effect on human ASCs. Indomethacin stimulates adipogenesis of human ASCs in 2 weeks cell culture and upregulates several key adipogenic genes including PPAR-gamma, lipoprotein lipase and fatty acid binding protein 4. For the first time, this work demonstrated in-vivo that melatonin enhances fat graft volume retention at 4 weeks by increasing the percentage of adipose volume within fat grafts with comparable volumes to that of cell-assisted lipotransfer. Melatonin treatment, however, had no effect on angiogenesis. Based on these findings, melatonin and indomethacin may potentially be useful pharmacological adjuncts in clinical fat grafting…

Subjects/Keywords: adipose-derived stem cells; fat grafting; regenerative medicine; reconstructive surgery; cytoprotection

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APA (6^th Edition):

Tan, S. S. (2016). Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/122069

Chicago Manual of Style (16^th Edition):

Tan, Shaun S. “Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function.” 2016. Masters Thesis, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/122069.

MLA Handbook (7^th Edition):

Tan, Shaun S. “Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function.” 2016. Web. 28 Feb 2021.

Vancouver:

Tan SS. Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function. [Internet] [Masters thesis]. University of Melbourne; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/122069.

Council of Science Editors:

Tan SS. Effect of melatonin and indomethacin on adipose-derived stem cells and fat graft survival and function. [Masters Thesis]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/122069

Michigan State University

24. Hayes, Schantel A. Identification and characterization of novel regulators of adipogenesis.

Degree: 2011, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:294

►

Thesis Ph. D. Michigan State University. Pathology 2011.

Adipocytes are highly specialized cells that are central to the control of energy balance and lipid homeostasis.… (more)

▼

Thesis Ph. D. Michigan State University. Pathology 2011.

Adipocytes are highly specialized cells that are central to the control of energy balance and lipid homeostasis. Obesity, the excess accumulation of adipose tissue, is a risk factor for type 2 diabetes, cardiovascular disease, hypertension and cancer. With global rates of obesity on the rise, it is important to study adipocyte biology and function to gain insight to the molecular basis of these metabolic diseases. There have been many significant advances in the study of adipocyte biology with the discovery of transcription factors, coactivators and growth factors that are involved in adipocyte differentiation. PPAR gamma is considered to be the master regulator of the terminal differentiation phase of adipogenesis and functions in concert with members of the CCAT/enhancer binding protein (C/EBP) family and Kruppel like factor family in a transcriptional cascade. Although much is known about the molecular mechanisms regulating the late phase of adipocyte differentiation, little is known about the transcriptional regulation of the early phase (determination) of adipogenesis as well as intracellular signaling pathways that are involved in this regulatory process. In our studies, we demonstrated that ZNF638, a transcription factor involved in the early phase of adipogenesis, is essential for adipocyte differentiation in vivo. In this study, we generated mice with adipose specific knockdown of ZNF638 (Fat-ZNF638-KD) by cre-lox interference. Fat-ZNF638-KD mice were smaller, weighed less and had a significant reduction of adipose tissue in all depots. Furthermore, mice were resistant to diet induced obesity that was potentiated by a higher metabolic rate and greater lean mass when compared to controls. mRNA expression levels of key adipogenic genes were reduced in the visceral depot of Fat-ZNF638-KD mice. We also demonstrated that nuclear matrix coactivator 1 (NMC1), a novel isoform of ZNF638, interacts with Smad4-interacting factor 1 (SMIF). SMIF, an activator of TGF beta signaling, was found to be highly regulated during adipocyte differentiation and to physically interact and repress the transcriptional activity of PPAR gamma. Lastly, we demonstrated that fat specific ablation of Serum Glucocorticoid Inducible Kinase 1 (SGK1), an AKC kinase involved in the early phase of adipocyte differentiation, results in sexual dimorphism. Our study showed that female mice have an increased fat mass, a decrease lean mass, increased visceral and inguinal adiposity and a trend for insulin resistance. Male mice were indistinguishable from their wild type littermate controls. These data show that our laboratory has identified and confirmed in vitro two novel regulators. We have also identified one potential regulator of adipocyte differentiation.

Description based on online resource; title from PDF t.p. (Nov. 23, 2011)

Advisors/Committee Members: Kiupel, Matti, Mueller, Elisabetta, Langohr, Ingeborg, Wagner, James, Simpson, Mark.

Subjects/Keywords: Fat cells; Obesity – Research; Metabolism – Disorders; Molecular biology; Pathology

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APA (6^th Edition):

Hayes, S. A. (2011). Identification and characterization of novel regulators of adipogenesis. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hayes, Schantel A. “Identification and characterization of novel regulators of adipogenesis.” 2011. Thesis, Michigan State University. Accessed February 28, 2021. http://etd.lib.msu.edu/islandora/object/etd:294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hayes, Schantel A. “Identification and characterization of novel regulators of adipogenesis.” 2011. Web. 28 Feb 2021.

Vancouver:

Hayes SA. Identification and characterization of novel regulators of adipogenesis. [Internet] [Thesis]. Michigan State University; 2011. [cited 2021 Feb 28]. Available from: http://etd.lib.msu.edu/islandora/object/etd:294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hayes SA. Identification and characterization of novel regulators of adipogenesis. [Thesis]. Michigan State University; 2011. Available from: http://etd.lib.msu.edu/islandora/object/etd:294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Guo, Wei. Novel role for dual-specificity phosphatase 4 in adipocytes.

Degree: 2017, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/Guo_uncg_0154D_12344.pdf

► The growing prevalence of obesity has resulted in a huge impact on global health. Obesity contributes to the development of cardiovascular diseases, insulin resistance (IR)… (more)

▼ The growing prevalence of obesity has resulted in a huge impact on global health. Obesity contributes to the development of cardiovascular diseases, insulin resistance (IR) and other comorbidities. Research over the past few decades has revealed important roles for adipose tissue (AT) in regulating whole-body metabolism under normal physiological and pathological states. It is well accepted that obesity-mediated chronic, low-grade inflammation contributes to the development of metabolic dysfunctions via the mitogen-activated protein kinase (MAPK) signaling pathways. While the upstream activation of MAPKs has been extensively investigated, how MAPK deactivation modulates cellular responses remains largely unsolved. In recent years, increasing attention has been given to the MAPK-specific, dual-specificity phosphatases (DUSPs) as key regulators that negatively control MAPK activity, potentially provide treatment against obesity-induced AT inflammation and IR. Early evidence has suggested a role for DUSP4 towards MAPKs signaling in other cell types. However, no study has addressed the role of DUSP4 in 3T3-L1 adipocytes under any condition. Data presented in this dissertation demonstrate that DUSP4 was induced via the MEK/ERK signaling pathway while JNK or p38 did not affect DUSP4 expression. Subsequently, we show that DUSP4 protein was also stabilized by ERK activation and proteasomal activity was partially involved in its protein degradation. Moreover, accumulation of DUSP4 correlated with the suppression of nuclear ERK signal and protein-protein interactions were observed between DUSP4 and ERK, suggesting a role for this phosphatase in spatiotemporal regulation of ERK activity in adipocytes. We further demonstrate that DUSP4 is suppressed in AT under conditions of genetic and diet-induced obesity that is associated with increased inflammation and IR. We report biphasic inductions of DUSP4 during adipocyte differentiation, with the early phase induction being ERK-dependent and the later phase induction being ERK-independent and differentiation-specific. Moreover, DUSP4 was suppressed in preadipocytes and adipocytes exposed to tumor necrosis factor-a. Additionally, DUSP4 knockdown did not inhibit adipocyte differentiation, suggesting a role for this phosphatase that is independent from adipogenesis. Collectively, data presented in this dissertation provide new insights into regulation and potential function of DUSP4 in adipocytes, highlighting new therapeutic targets for the treatment of obesity-mediated inflammation and metabolic disorders.

Subjects/Keywords: Dual specificity phosphatase 1; Insulin resistance; Fat cells; Inflammation

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APA (6^th Edition):

Guo, W. (2017). Novel role for dual-specificity phosphatase 4 in adipocytes. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/Guo_uncg_0154D_12344.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guo, Wei. “Novel role for dual-specificity phosphatase 4 in adipocytes.” 2017. Thesis, NC Docks. Accessed February 28, 2021. http://libres.uncg.edu/ir/uncg/f/Guo_uncg_0154D_12344.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guo, Wei. “Novel role for dual-specificity phosphatase 4 in adipocytes.” 2017. Web. 28 Feb 2021.

Vancouver:

Guo W. Novel role for dual-specificity phosphatase 4 in adipocytes. [Internet] [Thesis]. NC Docks; 2017. [cited 2021 Feb 28]. Available from: http://libres.uncg.edu/ir/uncg/f/Guo_uncg_0154D_12344.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guo W. Novel role for dual-specificity phosphatase 4 in adipocytes. [Thesis]. NC Docks; 2017. Available from: http://libres.uncg.edu/ir/uncg/f/Guo_uncg_0154D_12344.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of North Texas

26. Venable, Andrea Henning. Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia.

Degree: 2018, University of North Texas

URL: https://digital.library.unt.edu/ark:/67531/metadc1248401/

► It is well established that continual consumption of a diet high in fat leads to the development of chronic conditions such as obesity, cardio metabolic… (more)

Subjects/Keywords: Atherosclerosis; foam cells; monocytes; endotoxemia; PPAR-gamma; Spore-based probiotics; high-fat meal

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APA (6^th Edition):

Venable, A. H. (2018). Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia. (Thesis). University of North Texas. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc1248401/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Venable, Andrea Henning. “Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia.” 2018. Thesis, University of North Texas. Accessed February 28, 2021. https://digital.library.unt.edu/ark:/67531/metadc1248401/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Venable, Andrea Henning. “Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia.” 2018. Web. 28 Feb 2021.

Vancouver:

Venable AH. Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia. [Internet] [Thesis]. University of North Texas; 2018. [cited 2021 Feb 28]. Available from: https://digital.library.unt.edu/ark:/67531/metadc1248401/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Venable AH. Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia. [Thesis]. University of North Texas; 2018. Available from: https://digital.library.unt.edu/ark:/67531/metadc1248401/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of North Carolina – Greensboro

27. McNeill, Emily Helen. Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults.

Degree: 2016, University of North Carolina – Greensboro

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=21004

► The purpose of this study was to determine if diet and/or body composition influences resting plasma apelin concentration. Apelin concentration appears to be influenced by… (more)

▼ The purpose of this study was to determine if diet and/or body composition influences resting plasma apelin concentration. Apelin concentration appears to be influenced by the amount of fat in the body and by blood glucose concentration. However, most of the studies that have investigated blood apelin concentration have utilized obese or diabetic subjects. Little is known about how body composition, body fat distribution or diet may influence apelin in apparently healthy, young individuals. More specifically, the purposes of this study were to determine if baseline resting plasma apelin concentration in young, apparently healthy adult subjects is influenced by amount of fat in the body, location of fat, the macronutrient composition in their diet and if the total amount of antioxidant micronutrients (vitamins A, C, E and zinc). The proposed cohort group consisted of twelve apparently healthy young adults between the ages of 18-35.The amount of body fat, body mass index, sagittal diameter and the waist to hip ratio were utilized as covariates to determine if these factors influenced apelin concentration at rest. The data was analyzed to ascertain if there are any relationships with the listed anthropometric measures, the nutrition factors and plasma apelin concentration. Each subject’s body composition was classified via body mass index (BMI), sagittal abdominal diameter (SAD), waist circumference (WC) and 7-site skinfold analysis. In addition, Each subject completed a three day diet record prior to their three visits which were analyzed for total calories, macronutrient percent calories and amount of micronutrient antioxidants; vitamin A, C, E, and zinc. They were instructed on how to log 3 day diet records and were asked to repeat the diets as close as possible on their 2nd and 3rd visits to keep this information as consistent as possible. Significant relationships were found for body composition factors including Siri % body fat (r=0.631, P=0.028*), Brozek % body fat (r=0.642, P=0.024*), and BMI (r=0.649, P=0.022*). Body composition factors showed varied results. A significant association was found between sagittal abdominal diameter and plasma apelin concentrations at rest (r=0.628, p=0.029*), however waist circumference approached significance (r=0.061, P=0.061) and waist-to-hip ratio did not demonstrate a significant relationship (r=0.178, P=0.579). Only two subjects reported consuming high fat diets (>35% of total kilocalorie intake), therefore no relationships could be analyzed regarding plasma apelin concentration at rest and high fat diets. No significant relationships were found between individual micronutrients and plasma apelin concentrations at rest, besides vitamin E (r=0.658, P=0.020*). In conclusion this small cohort of subjects had stable resting plasma apelin levels across visits and does not appear that dietary factors influenced plasma apelin concentrations. In contrast, % BF and SAD suggest that these factors are significantly related to resting plasma apelin, with WC also approaching… Advisors/Committee Members: Allan Goldfarb (advisor).

Subjects/Keywords: Blood plasma; Cytokines; Body composition; Body mass index; Adipose tissues; Fat cells; Diet

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APA (6^th Edition):

McNeill, E. H. (2016). Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults. (Masters Thesis). University of North Carolina – Greensboro. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=21004

Chicago Manual of Style (16^th Edition):

McNeill, Emily Helen. “Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults.” 2016. Masters Thesis, University of North Carolina – Greensboro. Accessed February 28, 2021. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=21004.

MLA Handbook (7^th Edition):

McNeill, Emily Helen. “Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults.” 2016. Web. 28 Feb 2021.

Vancouver:

McNeill EH. Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults. [Internet] [Masters thesis]. University of North Carolina – Greensboro; 2016. [cited 2021 Feb 28]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=21004.

Council of Science Editors:

McNeill EH. Analyzing the role of body composition and diet in plasma apelin levels of normal healthy adults. [Masters Thesis]. University of North Carolina – Greensboro; 2016. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=21004

28. Chignon-Sicard, Bérengère. Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation.

Degree: Docteur es, Biologie moléculaire et cellulaire, 2018, Université Côte d'Azur (ComUE)

URL: http://www.theses.fr/2018AZUR4008

► Différents domaines en Chirurgie Plastique et Esthétique ont évolué au cours de ces dernières années et notamment le transfert et injection de Tissu Adipeux autologue.… (more)

▼ Différents domaines en Chirurgie Plastique et Esthétique ont évolué au cours de ces dernières années et notamment le transfert et injection de Tissu Adipeux autologue. Les premières données cliniques ont été présentées sans véritable appui scientifique. Cette thèse a pour objet de confirmer les données cliniques retrouvées et de permettre d’améliorer cette technique par des preuves scientifiques. Deux questions sont à considérer : 1) Le tissu adipeux a t-il selon son origine anatomique des caractéristiques différentes et certaines régions seraient-elles à privilégier lors d’une autogreffe ? 2) Existe t-il des facteurs de croissances autologues permettant de stimuler la prise de greffe, la prolifération et la différenciation des cellules greffées ? La première partie de ce travail a consisté à analyser le tissu adipeux en fonction du site de prélèvement. A cet effet, nous avons analysé le tissu adipeux provenant de 2 sites anatomiques : le genou et le menton. Le choix topographie découle d’une raison technique et d’une raison théorique. Nos résultats suggèrent que les deux sites étudiés ont des origines embryonnaires différentes, et montrent que ces deux sites présentent une signature moléculaire et une fonctionnalité différentes. La seconde partie porte sur l’effet in vitro de facteurs de croissances autologues humains. Nous avons analysé la prolifération et la différenciation de cellules souches adipogéniques (ASCs) humaines. Nous avons pour cela utilisé des concentrés plaquettaires issus de prélèvements sanguins autologues, et donc utilisables en pratique thérapeutique humaine. Il s’agit du PRF (plaquette riche en fibrine) et du PRP (plaquette riche en plasma). Les résultats de l’étude montrent que la présence de PRF ou de PRP dans le milieu de culture permet une augmentation drastique de la prolifération cellulaire d’environs 4 à 5 fois. A contrario, les résultats obtenus montrent un blocage partiel de la différenciation adipocytaire, quelque soit le moment et le temps de mise en contact. Nous avons alors étudié par quelle voie de blocage la différenciation était induit et avons montré l’implication de la voie du TGFB qui dans ces conditions de culture induit un blocage partiel de la différenciation des ASCs vers un adipocyte mature. Notre étude montre qu’en parallèle à l’effet antiadipogénique, la différenciation s’oriente vers des cellules myofibroblastes-like. Nous avons alors testé l’effet de l’ajout d’un inhibiteur du TGFB (SB431542) dans le milieu de culture et avons observé une relance de la différenciation cellulaire vers la voie adipogénique confirmant que le PRP a un effet antiadipogénique et promyofibroblastique. Par ailleurs, nous avons analysé la composition du PRP utilisé en dosant les taux de facteurs de croissance présents. En conclusion, ce travail permet de confirmer l’augmentation de la prolifération cellulaire des ASCs en présence de PRP autologue. Ceci nous permet donc une transposition clinique immédiate en utilisant en peropératoire l’association PRP et prélèvement de tissu adipeux lors d’un… Advisors/Committee Members: Dani, Christian (thesis director).

Subjects/Keywords: ASCs; Cellules souches; PRP; Greffe adipocytaire; ASCs; Stem cells; PRP; Fat grafting

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chignon-Sicard, B. (2018). Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation. (Doctoral Dissertation). Université Côte d'Azur (ComUE). Retrieved from http://www.theses.fr/2018AZUR4008

Chicago Manual of Style (16^th Edition):

Chignon-Sicard, Bérengère. “Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation.” 2018. Doctoral Dissertation, Université Côte d'Azur (ComUE). Accessed February 28, 2021. http://www.theses.fr/2018AZUR4008.

MLA Handbook (7^th Edition):

Chignon-Sicard, Bérengère. “Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation.” 2018. Web. 28 Feb 2021.

Vancouver:

Chignon-Sicard B. Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation. [Internet] [Doctoral dissertation]. Université Côte d'Azur (ComUE); 2018. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2018AZUR4008.

Council of Science Editors:

Chignon-Sicard B. Analyse moléculaire du tissu adipeux humain en fonction de sa localisation anatomique et effet du PRP (Plateled Rich Plasma) sur les progéniteurs adipeux humains (ASCs) : Effects of Platelet-Rich Plasma on human adipose progenitors and molecular analysis of human adipose tissues according to their anatomic localisation. [Doctoral Dissertation]. Université Côte d'Azur (ComUE); 2018. Available from: http://www.theses.fr/2018AZUR4008

University of Toronto

29. Zander, Mark Andrew. Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development.

Degree: PhD, 2014, University of Toronto

URL: http://hdl.handle.net/1807/68225

► Recent research is beginning to show that the molecular factors that regulate stem cells in lower organisms are conserved in mammals, where they play similar,… (more)

Subjects/Keywords: Apoptosis; Cell cycle; Cortical precursors; Fat atypical cadherin; Neural stem cells; Snail transcription fact; 0317

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zander, M. A. (2014). Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/68225

Chicago Manual of Style (16^th Edition):

Zander, Mark Andrew. “Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development.” 2014. Doctoral Dissertation, University of Toronto. Accessed February 28, 2021. http://hdl.handle.net/1807/68225.

MLA Handbook (7^th Edition):

Zander, Mark Andrew. “Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development.” 2014. Web. 28 Feb 2021.

Vancouver:

Zander MA. Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1807/68225.

Council of Science Editors:

Zander MA. Conserved Molecular Factors: Role of the Snail Family of Transcription Factors and the Fat Family of Atypical Cadherins in Cortical Development. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/68225

University of Aberdeen

30. Vaughan, Frances.; University of Aberdeen.College of Life Sciences and Medicine. Cold-sensing mechanisms in fat cells.

Degree: College of Life Sciences and Medicine., 2015, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=228015 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=228015&custom_att_2=simple_viewer

Subjects/Keywords: Fat cells; Ion channels.; Metabolism.; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaughan, F. ;. U. o. A. C. o. L. S. a. M. (2015). Cold-sensing mechanisms in fat cells. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=228015 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=228015&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Vaughan, Frances ; University of Aberdeen College of Life Sciences and Medicine. “Cold-sensing mechanisms in fat cells.” 2015. Doctoral Dissertation, University of Aberdeen. Accessed February 28, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=228015 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=228015&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Vaughan, Frances ; University of Aberdeen College of Life Sciences and Medicine. “Cold-sensing mechanisms in fat cells.” 2015. Web. 28 Feb 2021.

Vancouver:

Vaughan F;UoACoLSaM. Cold-sensing mechanisms in fat cells. [Internet] [Doctoral dissertation]. University of Aberdeen; 2015. [cited 2021 Feb 28]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=228015 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=228015&custom_att_2=simple_viewer.

Council of Science Editors:

Vaughan F;UoACoLSaM. Cold-sensing mechanisms in fat cells. [Doctoral Dissertation]. University of Aberdeen; 2015. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=228015 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=228015&custom_att_2=simple_viewer

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Open Access Theses and Dissertations