subject:(FITC Dextran)

1. SHEN LIJUAN. Characterization of microcapsule diffusion properties using confocal microscope.

Degree: 2005, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/14567

Subjects/Keywords: Diffusion; Microcapsule; Charge; FITC-BSA; FITC-dextran; Confocal microscope

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

LIJUAN, S. (2005). Characterization of microcapsule diffusion properties using confocal microscope. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/14567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LIJUAN, SHEN. “Characterization of microcapsule diffusion properties using confocal microscope.” 2005. Thesis, National University of Singapore. Accessed March 09, 2021. http://scholarbank.nus.edu.sg/handle/10635/14567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LIJUAN, SHEN. “Characterization of microcapsule diffusion properties using confocal microscope.” 2005. Web. 09 Mar 2021.

Vancouver:

LIJUAN S. Characterization of microcapsule diffusion properties using confocal microscope. [Internet] [Thesis]. National University of Singapore; 2005. [cited 2021 Mar 09]. Available from: http://scholarbank.nus.edu.sg/handle/10635/14567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LIJUAN S. Characterization of microcapsule diffusion properties using confocal microscope. [Thesis]. National University of Singapore; 2005. Available from: http://scholarbank.nus.edu.sg/handle/10635/14567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

2. Pinto, Sascha. A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/32488

►

The microvasculature has the main function of transport of dissolved gases, nutrients and waste between blood and tissue. Systematically probing transvascular transport rates in these… (more)

Subjects/Keywords: permeability; microvasculature; microfluidics; FITC-Dextran; artery-on-a-chip; 0541; 0548; 0433; 0719

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APA (6^th Edition):

Pinto, S. (2012). A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32488

Chicago Manual of Style (16^th Edition):

Pinto, Sascha. “A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels.” 2012. Masters Thesis, University of Toronto. Accessed March 09, 2021. http://hdl.handle.net/1807/32488.

MLA Handbook (7^th Edition):

Pinto, Sascha. “A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels.” 2012. Web. 09 Mar 2021.

Vancouver:

Pinto S. A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1807/32488.

Council of Science Editors:

Pinto S. A Microfluidic Platform for the Investigation of Transport in Small Blood Vessels. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32488

SUNY College at Brockport

3. Diamond, Amanda Marie. Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish.

Degree: MS, Biological Sciences, 2012, SUNY College at Brockport

URL: https://digitalcommons.brockport.edu/bio_theses/71

► Gastrointestinal motility patterns in humans are not constant and respond to the luminal contents and nutrient status (Degen and Phillips, 1996). The zebrafish is… (more)

▼ Gastrointestinal motility patterns in humans are not constant and respond to the luminal contents and nutrient status (Degen and Phillips, 1996). The zebrafish is a new model system for human GI motility and regulation of motility patterns appears to be controlled by enteric neurons and interstitial cells of Cajal (Huizinga et al., 1995, Farrugia et. al., 2003, Sanders et.al., 2006, Rich et. al., 2007). Although several research laboratories investigate GI motility in zebrafish larvae, no standard protocol for feeding exists and experiments may be performed on fasted or fed larvae. The goal of this study was to examine the effects of feeding on GI motility when ICC and enteric neurons are developed and regulate GI motor patterns in larvae, at 7 days post fertilization ( dpt) (Rich et. al., 2007). Larvae were fasted or fed once daily beginning at 5 dpf. At 7 dpf larvae were fed dry food labeled with FITC-dextran and GI motility was measured using time-lapse imaging and image analysis techniques. Motility was examined in the anterior and the posterior regions of the GI tract. No differences were observed in fish standard length, a developmental marker. The total number and distance of contractions increased in the anterior intestine after feeding. These data suggest that feeding has little influence on GI motility patterns in the posterior intestine. The effects of Cisapride, a prokinetic in humans, was examined and found to increase the contraction number, velocity, and interval. The effects of Niflumic Acid and DIDS were also examined, because anoctamin 1 (ANOl), a chloride-selective channel, has recently been identified as a potential regulator for ICC pacemaker function. Both drugs dramatically reduced the total number of contractions as well as the GI motility index indicating a reduction in coordinated motility patterns. Cisapride, Niflumic Acid, and DIDS have similar effects on GI motility in mice and in the zebrafish, suggesting that similar molecular mechanisms regulate GI motility in zebrafish and mice. The findings contribute to the validation of the zebrafish model system for human GI motility function. Advisors/Committee Members: Dr. Rich.

Subjects/Keywords: Motility patterns; zebrafish; larvae; prokinetic; FITC-dextran; Biology; Ecology and Evolutionary Biology; Integrative Biology

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APA (6^th Edition):

Diamond, A. M. (2012). Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish. (Thesis). SUNY College at Brockport. Retrieved from https://digitalcommons.brockport.edu/bio_theses/71

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Diamond, Amanda Marie. “Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish.” 2012. Thesis, SUNY College at Brockport. Accessed March 09, 2021. https://digitalcommons.brockport.edu/bio_theses/71.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Diamond, Amanda Marie. “Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish.” 2012. Web. 09 Mar 2021.

Vancouver:

Diamond AM. Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish. [Internet] [Thesis]. SUNY College at Brockport; 2012. [cited 2021 Mar 09]. Available from: https://digitalcommons.brockport.edu/bio_theses/71.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Diamond AM. Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish. [Thesis]. SUNY College at Brockport; 2012. Available from: https://digitalcommons.brockport.edu/bio_theses/71

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

De Montfort University

4. Jacob, Dolly. Investigation into reliability and performance of an implantable closed-loop insulin delivery device.

Degree: PhD, 2014, De Montfort University

URL: http://hdl.handle.net/2086/11126

► An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of… (more)

▼ An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contributes to insulin loss after 11 days, resin might not be the best material and polyurethane is the least compatible for future device designs. To study insulin delivery mechanism and kinetics from the device, fluorescently labelled human insulin (FITC-insulin) was synthesised and characterised using RP-HPLC and MS, to produce a product with predominantly di-labelled conjugate (>75%) with no unreacted FITC or native insulin. Clinically used insulin analogues were also fluorescently labelled to produce predominantly di-labelled FITC-insulin conjugate with potential future biological and in vitro applications. The drug release mechanism from the glucose sensitive gel held in the INsmart device, studied using fluorescein sodium was determined as a Fickian diffusion controlled release mechanism. The diffusion coefficient (D) for FITC-insulin in the non-polymerised dex2M-conA gel (NP gel) determined using mathematical models, QSS and TL slope methods was 1.05 ± 0.02 x 10-11 m2/s and in the cross-linked dex500MA-conAMA gel (CL gel) was 0.75 ± 0.06 x 10-11 m2/s. In response to physiologically relevant glucose triggers in the NP gel, the diffusivity of FITC-insulin increases with increasing glucose concentrations, showing a second order polynomial fit, device thus showing glucose sensitivity and graded response, mimicking pancreas. Rheological measurements further confirmed the gel glucose responsiveness demonstrated by a third order polynomial fit between FITC-insulin D and the NP complex viscosity in response to increasing glucose concentration. The knowledge of FITC-insulin diffusion kinetics in the gel has aided in making some theoretical predictions for the capability and performance of the INsmart device. Alternate device geometry and design optimisation is also explored.

Subjects/Keywords: 615.1; Implantable closed-loop insulin delivery device; INsmart device; Diabetes; Insulin; Fluorescent Insulin; Insulin analogues; FITC-insulin; drug release mechanism; Diffusion coefficient; Fickian diffusion; Diffusion kinetics; ConcanavalinA; Dextran; Glucose sensitive gel; glucose responsive gel; device material compatibility; RP-HPLC; pancreas; in vitro experiments; device geometry; device design

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jacob, D. (2014). Investigation into reliability and performance of an implantable closed-loop insulin delivery device. (Doctoral Dissertation). De Montfort University. Retrieved from http://hdl.handle.net/2086/11126

Chicago Manual of Style (16^th Edition):

Jacob, Dolly. “Investigation into reliability and performance of an implantable closed-loop insulin delivery device.” 2014. Doctoral Dissertation, De Montfort University. Accessed March 09, 2021. http://hdl.handle.net/2086/11126.

MLA Handbook (7^th Edition):

Jacob, Dolly. “Investigation into reliability and performance of an implantable closed-loop insulin delivery device.” 2014. Web. 09 Mar 2021.

Vancouver:

Jacob D. Investigation into reliability and performance of an implantable closed-loop insulin delivery device. [Internet] [Doctoral dissertation]. De Montfort University; 2014. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2086/11126.

Council of Science Editors:

Jacob D. Investigation into reliability and performance of an implantable closed-loop insulin delivery device. [Doctoral Dissertation]. De Montfort University; 2014. Available from: http://hdl.handle.net/2086/11126

5. Αβραμίδης, Νικόλαος. Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα.

Degree: 2003, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); Aristotle University Of Thessaloniki (AUTH)

URL: http://hdl.handle.net/10442/hedi/14779

►

Παρόλη την ανάπτυξη της τεχνολογίας και την εισαγωγή νέων τεχνικών, όπως του ανασυνδυασμένου DNA, που επιτρέπουν την ανάπτυξη αντιγόνων υψηλής καθαρότητας για την επαγωγή ειδικής… (more)

▼

Παρόλη την ανάπτυξη της τεχνολογίας και την εισαγωγή νέων τεχνικών, όπως του ανασυνδυασμένου DNA, που επιτρέπουν την ανάπτυξη αντιγόνων υψηλής καθαρότητας για την επαγωγή ειδικής ανοσοαπόκρισης, σήμερα υπάρχουν μια σειρά από ασθένειες που δεν μπορούν να προληφθούν με τα υπάρχοντα εμβόλια. Μια τέτοια ασθένεια είναι η νόσος της αγαλαξίας των αιγοπροβάτων που προκαλεί μαστίτιδα, αρθρίτιδα, κερατίτιδα και αγαλαξία με αποτέλεσμα τις σοβαρές οικονομικές επιπτώσεις στη κτηνοτροφία. Η νόσος αυτή οφείλεται στο μυκόπλασμα της αγαλαξίας (Mycoplasma agalactiae), που ανήκει στο γένος των μυκοπλασμάτων (Mycoplasma) που περιλαμβάνει μια σειρά παθογόνων μικροοργανισμών, όπως το μυκόπλασμα της πνευμονίας. Πρέπει να σημειωθεί πως έχουν βρεθεί δεκάδες αντιγονικές ομάδες των μυκοπλασμάτων που μπορούν να χρησιμοποιηθούν κυρίως για την αναγνώριση τους, ενώ τα εμβόλια που κατασκευάστηκαν μέχρι σήμερα βασίζονται κυρίως στην εμπειρική μέθοδο. Παράλληλα, προηγούμενες έρευνες του εργαστηρίου μας έδειξαν ότι ο μηχανισμός επιλογής του ισότυπου των αντισωμάτων επηρεάζεται από τα ανοσοενισχυτικά που χρησιμοποιούνται κατά την ανοσοποίηση. Τα ανοσοενισχυτικά επιδρούν στη χυμική απόκριση αυξάνοντας την ποσότητα, τη συγγένεια για αντιγόνο και τροποποιώντας τον ισότυπο των αντισωμάτων που παράγονται. Η επίδραση αυτή γίνεται δια μέσω της δράσης των κυτοκινών που εκκρίνονται από συγκεκριμένους υποπληθυσμούς των Τ-λεμφοκυττάρων μετά τη χορήγηση των ανοσοενισχυτικών σε συνδυασμό με το αντιγόνο. Έτσι η μελέτη της παρούσας διατριβής, συνδυάζει την έρευνα γύρω από το μηχανισμό δράσης των ανοσοενισχυτικών και τον καθορισμό του τύπου απόκρισης των μυκοπλασμάτων της αγαλαξίας ώστε να γίνει δυνατή η κατασκευή ολοκληρωμένου εμβολίου για τη συγκεκριμένη νόσο. Ταυτόχρονα, ολοκληρώνει την έρευνα γύρω από τη σχέση ανοσοενισχυτικών - κυτοκινών - αντισωμάτων, με τη μελέτη της επαγωγής των κυτοκινών μετά τη χορήγηση ανοσοενισχυτικών σε συνδυασμό με το διαλυτό θυμοανεξάρτητο αντιγόνο δεξτράνιο-φλουορεσκεϊνη. Τέλος, γίνεται η μελέτη της μελανίνης ως πιθανού ανοσοενισχυτικού.

In spite of the development of technology and the new techniques, as the recombinant DNA, which allow the production of high pure antigens to induce specific immune responses, there are even in our days a plenty of diseases which cannot be prevented via the existed vaccines. Such a disease is infection of Mycoplasma agalactiae, which causes mastitis, arthritis, keratoconjunctivitis and agalactia in small ruminants. Mycoplasma agalactia belongs to family of Mycoplasmataceae, which includes microorganisms’ pathogens, as pneumonia Mycoplasma. They have been discovered a plenty of Mycoplasma’ s antigens which can be used in order to recognize them. In previous studies, we have shown that isotype selection is affected by the adjuvant used for immunization. The…

Subjects/Keywords: Κυτοκίνες; Ισότυποι αντισωμάτων; Ανοσοενισχυτικά; Μυκόπλασμα αγαλαξίας; Δεξτράνιο; Φλουορεσκείνη; Μελανίνη; Cytokines; Isotype of antibodies; Adjuvants; Mycoplasma agalactiae; Dextran; Fitc; Melanin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Αβραμίδης, �. (2003). Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα. (Thesis). Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); Aristotle University Of Thessaloniki (AUTH). Retrieved from http://hdl.handle.net/10442/hedi/14779

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Αβραμίδης, Νικόλαος. “Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα.” 2003. Thesis, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); Aristotle University Of Thessaloniki (AUTH). Accessed March 09, 2021. http://hdl.handle.net/10442/hedi/14779.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Αβραμίδης, Νικόλαος. “Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα.” 2003. Web. 09 Mar 2021.

Vancouver:

Αβραμίδης �. Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα. [Internet] [Thesis]. Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); Aristotle University Of Thessaloniki (AUTH); 2003. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/10442/hedi/14779.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Αβραμίδης �. Επίδραση των ανοσοενισχυτικών στην παραγωγή κυτοκινών και στον ισότυπο των αντισωμάτων σε θυμοεξαρτώμενα και θυμοανεξάρτητα αντιγόνα. [Thesis]. Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); Aristotle University Of Thessaloniki (AUTH); 2003. Available from: http://hdl.handle.net/10442/hedi/14779

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cleveland State University

6. Nag, Subhra Sankar. Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport.

Degree: PhD, College of Sciences and Health Professions, 2018, Cleveland State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=csu1536931227678351

► Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal… (more)

▼ Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal epithelia adjacent to a cyst. We hypothesize that in normal epithelia near a cyst, the stabilization of Hypoxia Inducible Factor 1a (HIF1a), a major regulator of cellular response to hypoxia, can cause altered paracellular and transcellular transport, transforming a normal absorptive phenotype to a secretory and paracellularly leaky phenotype, leading to cyst expansion.Using 100 µmol/L cobalt chloride (CoCl2), HIF1a was stabilized in cellular nucleus of a mouse cortical collecting duct cell line (mCCD 1296 (d)), which resulted in an increased level of erythropoietin, an effector and reporter molecule of HIF1a. The mCCD monolayers have a high transepithelial resistance (TER) value (¿ 3000 O-cm2) and around 95% amiloride-sensitive voltage value. Equivalent current was calculated to compare active ion transport. Our results showed that TER values decreased significantly after 48 and 72 hours of HIF-stabilization. The decrease of TER value was consistent with the increase in the permeability of 70 kDa FITC-dextran molecules, supporting the hypothesis that HIF-stabilization altered paracellular transport. Stabilization of HIF caused a significant decrease in the protein level of zonula occludin 1 (ZO1), which controls paracellular transport through tight junctions. Decrease in the ZO1 protein level was consistent with the decreased TER value and the increased paracellular permeability. Similarly, HIF-stabilization was found to increase paracellular permeability in Mardin-Darby Canine Kidney (MDCK) epithelial monolayers. In mCCD monolayers, HIF-stabilization for 48 hours caused loss of active sodium ion (Na+) transport, and very interestingly, 72 hours of HIF-stabilization caused a switch in the direction of net active ion transport. HIF-stabilization caused a significant decrease of protein level of sodium-potassium-ATPase (Na+/ K+-ATPase) a1 subunit, the catalytic subunit of the enzyme responsible for active Na+ transport, consistent with the loss of active transport of Na+. Our results indicate that HIF-stabilization can transform a normal absorptive epithelium to a paracellularly leaky and cyst-like secretory epithelium by reversing net Na+ transport and increasing monolayer permeability due to alterations of tight junctions, and thereby HIF-stabilization may contribute to cyst expansion. Advisors/Committee Members: Renick, Andrew (Committee Chair).

Subjects/Keywords: Biophysics; Biomedical Research; Biology; Cellular Biology; Kidney Cyst; PKD; Renal Transepithelial Transport; Active Na Transport; Passive Transport; Electrophysiology; TER; Equivalent Current; CoCl2; Hypoxia; HIF; Epithelial Tight Junction; FITC-dextran Permeability; ZO1; Na-K-ATPase; ENaC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nag, S. S. (2018). Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport. (Doctoral Dissertation). Cleveland State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=csu1536931227678351

Chicago Manual of Style (16^th Edition):

Nag, Subhra Sankar. “Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport.” 2018. Doctoral Dissertation, Cleveland State University. Accessed March 09, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=csu1536931227678351.

MLA Handbook (7^th Edition):

Nag, Subhra Sankar. “Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport.” 2018. Web. 09 Mar 2021.

Vancouver:

Nag SS. Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport. [Internet] [Doctoral dissertation]. Cleveland State University; 2018. [cited 2021 Mar 09]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1536931227678351.

Council of Science Editors:

Nag SS. Stabilization of Hypoxia Inducible Factor by Cobalt Chloride Can Alter Renal Transepithelial Transport. [Doctoral Dissertation]. Cleveland State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=csu1536931227678351

7. Slatculescu, Andreea M. Immune Dysfunction Associated with Hemodialysis Modalities .

Degree: 2014, University of Ottawa

URL: http://hdl.handle.net/10393/30493

► Infection is a leading cause of death in hemodialysis patients, partly due to dysfunctional immunity. Frequent dialysis therapy improves patient outcomes and quality of life.… (more)

Subjects/Keywords: Hemodialysis; Dialysis; Home Hemodialysis; Adaptive immunity; Monocyte-derived dendritic cells; T-lymphocytes; Serum cytokines; C reactive protein; co-stimulatory molecules; FITC-dextran endocytosis; Flow Cytometry; Cell proliferation

…47 Figure 9: MDDC FITC-dextran endocytosis is similar in all study participants… …51 Figure 11: Expression of CD206 correlates with FITC-dextran uptake… …cell sorting FCS fetal calf serum FITC fluorescein isothiocyanate GM-CSF granulocyte…

14 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Slatculescu, A. M. (2014). Immune Dysfunction Associated with Hemodialysis Modalities . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/30493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Slatculescu, Andreea M. “Immune Dysfunction Associated with Hemodialysis Modalities .” 2014. Thesis, University of Ottawa. Accessed March 09, 2021. http://hdl.handle.net/10393/30493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Slatculescu, Andreea M. “Immune Dysfunction Associated with Hemodialysis Modalities .” 2014. Web. 09 Mar 2021.

Vancouver:

Slatculescu AM. Immune Dysfunction Associated with Hemodialysis Modalities . [Internet] [Thesis]. University of Ottawa; 2014. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/10393/30493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Slatculescu AM. Immune Dysfunction Associated with Hemodialysis Modalities . [Thesis]. University of Ottawa; 2014. Available from: http://hdl.handle.net/10393/30493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Kazemi, Amir Sadegh. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.

Degree: PhD, 2018, McMaster University

URL: http://hdl.handle.net/11375/23404

►

Membrane filtration processes are widely utilized across different industrial sectors for biological and environmental separations. Examples of the former are sterile filtration and protein fractionation… (more)

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Membrane filtration processes are widely utilized across different industrial sectors for biological and environmental separations. Examples of the former are sterile filtration and protein fractionation via microfiltration (MF) and ultrafiltration (UF) while drinking water treatment, tertiary treatment of wastewater, water reuse and desalination via MF, UF, nanofiltration (NF) and reverse-osmosis (RO) are examples of the latter. A common misconception is that the performance of membrane separation is solely dependent on the membrane pore size, whereas a multitude of parameters including solution conditions, solute concentration, presence of specific ions, hydrodynamic conditions, membrane structure and surface properties can significantly influence the separation performance and the membrane’s fouling propensity. The conventional approach for studying filtration performance is to use a single lab- or pilot-scale module and perform numerous experiments in a sequential manner which is both time-consuming and requires large amounts of material. Alternatively, high-throughput (HT) techniques, defined as the miniaturized version of conventional unit operations which allow for multiple experiments to be run in parallel and require a small amount of sample, can be employed. There is a growing interest in the use of HT techniques to speed up the testing and optimization of membrane-based separations. In this work, different HT screening approaches are developed and utilized for the evaluation and optimization of filtration performance using flat-sheet and hollow-fiber (HF) membranes used in biological and environmental separations. The effects of various process factors were evaluated on the separation of different biomolecules by combining a HT filtration method using flat-sheet UF membranes and design-of-experiments methods. Additionally, a novel HT platform was introduced for multi-modal (constant transmembrane pressure vs. constant flux) testing of flat-sheet membranes used in bio-separations. Furthermore, the first-ever HT modules for parallel testing of HF membranes were developed for rapid fouling tests as well as extended filtration evaluation experiments. The usefulness of the modules was demonstrated by evaluating the filtration performance of different foulants under various operating conditions as well as running surface modification experiments. The techniques described herein can be employed for rapid determination of the optimal combination of conditions that result in the best filtration performance for different membrane separation applications and thus eliminate the need to perform numerous conventional lab-scale tests. Overall, more than 250 filtration tests and 350 hydraulic permeability measurements were performed and analyzed using the HT platforms developed in this thesis.

Thesis

Doctor of Philosophy (PhD)

Membrane filtration is widely used as a key separation process in different industries. For example, microfiltration (MF) and ultrafiltration (UF) are used for sterilization and…

Advisors/Committee Members: Latulippe, David, Chemical Engineering.

Subjects/Keywords: Membrane filtration; Ultrafiltration; Downstream bio-processing; High-throughput (HT) testing; Wastewater treatment; Hollow-fiber membranes; Humic acids; High-throughput filtration; Design-of-experiments (DOE); Process optimization; Microscale filtration; Microfluidic flow control system; Stirred well filtration; SWF; High-throughput hollow-fiber module; HT-HF; Constant TMP; Constant flux; Multi-modal filtration; Bioseparation; MMFC; Microscale parallel-structured, cross-flow filtration; MS-PS-CFF; PEG; Dextran; FITC-Dextran; BSA; DNA; IgG; α-lactalbumin; Biomolecule separation; Module hydrodynamics; Concentration polarization; Membrane fouling; Micromixing; Omega™ membrane; Microscale processing; Fouling test; PVDF membrane; Surface modification; Polydopamine; Membrane cleaning; Membrane backwashing; Sodium alginate; Polyethersulfone; PES; Hydraulic permeability; Membrane permeability; ZeeWeed® membrane; Filtration ionic strength; Filtration pH; Solution conditions; Water treatment; Environmental separations; Biological separations

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APA (6^th Edition):

Kazemi, A. S. (2018). Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/23404

Chicago Manual of Style (16^th Edition):

Kazemi, Amir Sadegh. “Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.” 2018. Doctoral Dissertation, McMaster University. Accessed March 09, 2021. http://hdl.handle.net/11375/23404.

MLA Handbook (7^th Edition):

Kazemi, Amir Sadegh. “Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications.” 2018. Web. 09 Mar 2021.

Vancouver:

Kazemi AS. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. [Internet] [Doctoral dissertation]. McMaster University; 2018. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/11375/23404.

Council of Science Editors:

Kazemi AS. Development of High-throughput Membrane Filtration Techniques for Biological and Environmental Applications. [Doctoral Dissertation]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23404

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