subject:(Eye Diseases)

University of Namibia

1. Amoomo, Alfons. Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia .

Degree: 2010, University of Namibia

URL: http://hdl.handle.net/11070/518

► Abstract provided by author; Primary open-angle glaucoma (POAG) is the major cause of irreversible blindness worldwide among black people. Early detection and treatment can prevent… (more)

▼ Abstract provided by author; Primary open-angle glaucoma (POAG) is the major cause of irreversible blindness worldwide among black people. Early detection and treatment can prevent blindness, a consequence of glaucoma. Individuals need to be aware of glaucoma and seek assessment regularly for early detection and diagnosis of the disease. Awareness of glaucoma has not been previously documented in a Namibian setting. The aim of this study was to explore and describe the awareness of glaucoma that clients have who attended the out patient department (OPD) at the Intermediate Hospital Oshakati (IHO), Northern Namibia. Objectives of the study were to explore and describe the awareness of clients regarding glaucoma attending the OPD of IHO and to identify specific awareness raising strategies on glaucoma as a means to prevent glaucoma visual impairments. The study was conducted in November 2010 at the OPD of the said hospital. The research tool was an interview guide which was administered to 400 respondents between the ages of 40-70 years who attended the OPD. Face to face interview was used and interview guide's data included sociodemographics of the respondents, their awareness and knowledge about glaucoma and the usefulness of effective communication strategies and awareness raising of the disease. Sixty percent (60.0) of respondents were female and 40.0of respondents were male; 64.8of respondents were unemployed, 22.3were employed and 13.0 were retired. In terms education levels 44.5 completed primary school, 15.0 of respondents did not complete primary education, 22.0 completed secondary school, 13.8 did not attend any formal school and only 4.5 completed an undergraduate degree. The majority of respondents (99.0) were aware that glaucoma is a blinding eye condition. None of the respondents knew that glaucoma is a common eye condition in which fluid pressure inside the eye rises because of slow fluid drainage from the eye. Awareness of glaucoma was independent of age, gender, employment status and educational status. Age and positive family history were mostly identified by respondents as the greatest risk factor for glaucoma. An overwhelming majority of respondents (99.3) were aware that information, education and communication (IEC) materials are useful in increasing knowledge of glaucoma; all of them believed that effective health communication is the best strategy to raise glaucoma awareness. The majority of people are aware that glaucoma is a blinding condition but cannot describe the condition or mention any associated risk factors thus glaucoma knowledge in this study population is very low. There is a need to adequately inform and educate people about their health, especially eye health. An efficient IEC and population screening strategy needs to be designed to increase the community's knowledge about glaucoma so that early diagnosis and treatment of individuals with glaucoma may be possible; Advisors/Committee Members: Van der Vyver M (advisor), Nauiseb T (advisor).

Subjects/Keywords: Glaucoma ; Eye Diseases

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APA (6^th Edition):

Amoomo, A. (2010). Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia . (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Amoomo, Alfons. “Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia .” 2010. Thesis, University of Namibia. Accessed January 17, 2021. http://hdl.handle.net/11070/518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Amoomo, Alfons. “Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia .” 2010. Web. 17 Jan 2021.

Vancouver:

Amoomo A. Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia . [Internet] [Thesis]. University of Namibia; 2010. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11070/518.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Amoomo A. Glaucoma awareness among clients present at the outpatient department of Intermediate hospital, Oshakati, Northern Namibia . [Thesis]. University of Namibia; 2010. Available from: http://hdl.handle.net/11070/518

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Montana

2. Schultz, George A. Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats.

Degree: MA, 1958, University of Montana

URL: https://scholarworks.umt.edu/etd/6262

Subjects/Keywords: Eye Diseases.

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APA (6^th Edition):

Schultz, G. A. (1958). Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/6262

Chicago Manual of Style (16^th Edition):

Schultz, George A. “Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats.” 1958. Masters Thesis, University of Montana. Accessed January 17, 2021. https://scholarworks.umt.edu/etd/6262.

MLA Handbook (7^th Edition):

Schultz, George A. “Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats.” 1958. Web. 17 Jan 2021.

Vancouver:

Schultz GA. Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats. [Internet] [Masters thesis]. University of Montana; 1958. [cited 2021 Jan 17]. Available from: https://scholarworks.umt.edu/etd/6262.

Council of Science Editors:

Schultz GA. Study in the developmental anatomy of the eye in a selected series of postnatal microphthalmic white rats. [Masters Thesis]. University of Montana; 1958. Available from: https://scholarworks.umt.edu/etd/6262

Michigan State University

3. Caraway, Prentice Alvin. A morphological study of an eye anomaly in the albino rat.

Degree: MS, 1948, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:10900

Subjects/Keywords: Eye – Diseases

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APA (6^th Edition):

Caraway, P. A. (1948). A morphological study of an eye anomaly in the albino rat. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:10900

Chicago Manual of Style (16^th Edition):

Caraway, Prentice Alvin. “A morphological study of an eye anomaly in the albino rat.” 1948. Masters Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:10900.

MLA Handbook (7^th Edition):

Caraway, Prentice Alvin. “A morphological study of an eye anomaly in the albino rat.” 1948. Web. 17 Jan 2021.

Vancouver:

Caraway PA. A morphological study of an eye anomaly in the albino rat. [Internet] [Masters thesis]. Michigan State University; 1948. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:10900.

Council of Science Editors:

Caraway PA. A morphological study of an eye anomaly in the albino rat. [Masters Thesis]. Michigan State University; 1948. Available from: http://etd.lib.msu.edu/islandora/object/etd:10900

University of Zambia

4. Mulipilwa, Martin Dokela. The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4353

► Background The iris is the coloured part around the black pupil. It is a flat structure and each iris is unique in its colour, patterns… (more)

Subjects/Keywords: Opthalmology; Eye diseases; Iris(eye); Iris – Examinations; Iris – diseases – Zambia

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APA (6^th Edition):

Mulipilwa, M. D. (2015). The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mulipilwa, Martin Dokela. “The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba .” 2015. Thesis, University of Zambia. Accessed January 17, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mulipilwa, Martin Dokela. “The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba .” 2015. Web. 17 Jan 2021.

Vancouver:

Mulipilwa MD. The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Jan 17]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mulipilwa MD. The color of the Iris in patients presenting at the Opthalmology unit University teaching hospital Lusaka,Zamba . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

5. Roussou, Douwna. 'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings.

Degree: 2008, University of Johannesburg

URL: http://hdl.handle.net/10210/764

►

The purpose of this research was to develop a psycho-educational counselling programme for the handling of people suffering from a severe ophthalmologically challenge. It appears… (more)

▼

The purpose of this research was to develop a psycho-educational counselling programme for the handling of people suffering from a severe ophthalmologically challenge. It appears that people who are severely ophthalmologically challenged do not only experience it physically but also experience negative feelings such as a crumbling self-image, a lack of self-confidence, various fears as well as depression. Their state of mind induces a change with regard to their interpersonal relationships because they avoid social interaction, as well as feelings of loss and they experience a change regarding acceptance by others. However, it has transpired that people who are severely ophthalmologically challenged make use of various mechanisms such as support by others, the gathering of information and humour in order to handle their ophthalmological challenges. Society attaches so much importance to external appearance which does not make it easier for a person suffering from a physical "dissimilarity" and it influences the person's metal health. As a consequence the researcher began asking the following questions: 1. What does the world in which a severely ophthalmologically challenged person live, look like? 2. How can a psycho-educational counselling programme lead such a person to mental health and self-acceptance? A qualitative, explorative, descriptive and contextual research design was followed. The research took place in four phases: In phase 1 the experiences of people with severe ophthalmological challenges were explored and described, by means of phenomenological, unstructured, in-depth interviews with the patient and significant others such as parents, spouses and children. In phase 2 the psycho-educational programme for the person with severe ophthalmological challenges was developed based on the results of phase 1. In phase 3 this psycho-educational counselling programme was implemented. During phase 4 the evaluation of the psycho-educational programme took place by means of a single case study. The motivation behind the development of such a programme was to create a framework in which people with severe ophthalmological challenges could develop constructive interpersonal communication skills. They could also be afforded the opportunity to reflect through discourse. By attaching significance to their discourse they can accept their changing circumstances and act self-assertively. The programme has been facilitated so that psycho-educationists and other professionals may use it to facilitate the counselling programme to improve mental health for people who are severely ophthalmologically challenged.

Prof. C.P.H. Myburgh Prof. M.Poggenpoel

Subjects/Keywords: Ophthalmology; Eye diseases

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APA (6^th Edition):

Roussou, D. (2008). 'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/764

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roussou, Douwna. “'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings.” 2008. Thesis, University of Johannesburg. Accessed January 17, 2021. http://hdl.handle.net/10210/764.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roussou, Douwna. “'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings.” 2008. Web. 17 Jan 2021.

Vancouver:

Roussou D. 'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings. [Internet] [Thesis]. University of Johannesburg; 2008. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10210/764.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roussou D. 'n Psigo-opvoedkundige begeleidingsprogram vir persone met erge oftalmologiese uitdagings. [Thesis]. University of Johannesburg; 2008. Available from: http://hdl.handle.net/10210/764

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

6. Sukha, Anusha Yasvantrai. Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/9990

►

M.Phil. (Optometry)

Despite many years of research, diabetic retinopathy (DR), and diabetic macular edema (DME) remain difficult to diagnose, prevent, and treat. The complicated nature… (more)

▼

M.Phil. (Optometry)

Despite many years of research, diabetic retinopathy (DR), and diabetic macular edema (DME) remain difficult to diagnose, prevent, and treat. The complicated nature of the disease, the limited information on DR and DME and the increasing prevalence of diabetes mellitus (DM) in South Africa, provided motivation for this study. To the best of my knowledge, this is the first study in our country to identify demographic, medical and visual aspects ofDR and DME collectively. A further incentive was the availability in optometry of recently developed computer software based upon multivariate statistics, which provided a unique opportunity to analyze, for example, tri-variate contrast sensitivity acuities using stereo-pair scatter plots. All refractive status measurements were also analyzed and compared with the same method. Together, the results from this study provide a broader clinical and research perceptive on DR and DME. In this cross-sectional study, 202 diabetic patients at the Helen Joseph Hospital in Johannesburg were recruited. Demographic variables included age, gender, race, age of diagnosis, duration of DM, and social habits. Medical variables included systemic conditions present, blood pressures, body mass index (BMI), lipid profiles, glycerated haemoglobin (HbAlc), and other available biochemical data (for example cholesterol, urea and creatinine levels). Visual variables included, distance, pinhole and near visual acuities, contrast sensitivity acuities, refractive status measured with autorefraction, colour vision, Amsler grid, intraocular pressures (lOP), and fundus photography. Administration of the Impact of Visuallmpainnent (IVI) questionnaire provided new information concerning the restrictions in daily living participation caused by DR or DME. The predominant characteristics of the study population consisted of Type 1DM among female Coloured subjects. Approximately 66% of all subjects had also been diagnosed with hypertension. The mean age ofthe subjects was 52 (± 14) years, age of diagnosis 41 (± 13) years, and duration ofDM 10.8 (± 9.7) years. Mean blood pressures (136/81 ± 20.5/11 mmHg) and glycated haemoglobin (HbAlc, 9.9 ± 3.4%) values were slightly higher than the recommended control levels (BP= 120/80 mmHg and HbAlc = 6 to 7%).

Subjects/Keywords: Diabetic retinopathy; Retinal degeneration; Diabetes; Eye - Diseases

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APA (6^th Edition):

Sukha, A. Y. (2014). Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/9990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sukha, Anusha Yasvantrai. “Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema.” 2014. Thesis, University of Johannesburg. Accessed January 17, 2021. http://hdl.handle.net/10210/9990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sukha, Anusha Yasvantrai. “Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema.” 2014. Web. 17 Jan 2021.

Vancouver:

Sukha AY. Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10210/9990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sukha AY. Demographic, medical and visual aspects of diabetic retinopathy and diabetic macular edema. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/9990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

7. Li, Aiwei. Controlled release of small protein therapeutic from in situ hydrogel.

Degree: 2013, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-65740 ; https://doi.org/10.14711/thesis-b1254365 ; http://repository.ust.hk/ir/bitstream/1783.1-65740/1/th_redirect.html

► An innovative biocompatible and degradable in situ hydrogel that can form rapidly under physiological condition by Michael type addition reaction between vinyl sulfone modified hyaluronic… (more)

Subjects/Keywords: Colloids ; Protein drugs ; Eye ; Diseases ; Treatment

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APA (6^th Edition):

Li, A. (2013). Controlled release of small protein therapeutic from in situ hydrogel. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-65740 ; https://doi.org/10.14711/thesis-b1254365 ; http://repository.ust.hk/ir/bitstream/1783.1-65740/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Aiwei. “Controlled release of small protein therapeutic from in situ hydrogel.” 2013. Thesis, Hong Kong University of Science and Technology. Accessed January 17, 2021. http://repository.ust.hk/ir/Record/1783.1-65740 ; https://doi.org/10.14711/thesis-b1254365 ; http://repository.ust.hk/ir/bitstream/1783.1-65740/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Aiwei. “Controlled release of small protein therapeutic from in situ hydrogel.” 2013. Web. 17 Jan 2021.

Vancouver:

Li A. Controlled release of small protein therapeutic from in situ hydrogel. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2013. [cited 2021 Jan 17]. Available from: http://repository.ust.hk/ir/Record/1783.1-65740 ; https://doi.org/10.14711/thesis-b1254365 ; http://repository.ust.hk/ir/bitstream/1783.1-65740/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li A. Controlled release of small protein therapeutic from in situ hydrogel. [Thesis]. Hong Kong University of Science and Technology; 2013. Available from: http://repository.ust.hk/ir/Record/1783.1-65740 ; https://doi.org/10.14711/thesis-b1254365 ; http://repository.ust.hk/ir/bitstream/1783.1-65740/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

8. Ko, Wai Lun. Characterization of corneal biomechanical properties and applications in glaucoma risk assessment.

Degree: 2013, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-81393 ; https://doi.org/10.14711/thesis-b1251887 ; http://repository.ust.hk/ir/bitstream/1783.1-81393/1/th_redirect.html

► A primary indicator of glaucoma is intraocular pressure (IOP). Precision measurement of the IOP depends on accurate measurement of corneal radius, thickness and biomechanical properties.… (more)

▼ A primary indicator of glaucoma is intraocular pressure (IOP). Precision measurement of the IOP depends on accurate measurement of corneal radius, thickness and biomechanical properties. While in vivo methods for measurement of corneal thickness and radius are available, methods to measure the corneal biomechanical properties have yet been developed. To address this gap, a non-invasive indentation-based method to measure corneal biomechanical elastic tangent modulus in vivo was developed in this study. The feasibility and accuracy of the approach was first investigated on a universal testing machine (UTM) with a customized indenter, and tested using pressurized silicone rubber cornea. Analysis and comparison with elastic properties from three-point bending test showed excellent agreement with an average measurement difference under 0.10%. Afterward, the method was tested on porcine eyes ex vivo and rabbit eyes in vivo respectively. Biological porcine and rabbit corneas are viscoelastic in nature while the liquid in the eye chamber supporting the cornea is also viscoelastic. Indentation tests showed that the systematic viscoelastic contributions becomes negligible only at high indentation rate, and the rate-independent corneal tangent modulus can be reliably measured at indentation rates above 20 mm/min for pressurized porcine eyes and for rabbit eyes in vivo On this basis, a handheld corneal indentation device (CID) suited for use in clinical setting was developed. Comparisons with UTM showed that the average measurement difference is smaller than 1% in silicone rubber cornea and in porcine eye ex vivo. Further testing showed that the intraclass correlation coefficient (ICC) for the CID measurement is 0.993 and 0.890 in porcine eyes ex vivo and human eye in vivo respectively. With corneal properties in vivo available from CID, the effect of corneal properties in individual patient can be accounted for in IOP measurements to improve screening and diagnosis of glaucoma in patients.

Subjects/Keywords: Glaucoma ; Risk assessment ; Cornea ; Pathophysiology ; Eye ; Diseases

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APA (6^th Edition):

Ko, W. L. (2013). Characterization of corneal biomechanical properties and applications in glaucoma risk assessment. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-81393 ; https://doi.org/10.14711/thesis-b1251887 ; http://repository.ust.hk/ir/bitstream/1783.1-81393/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ko, Wai Lun. “Characterization of corneal biomechanical properties and applications in glaucoma risk assessment.” 2013. Thesis, Hong Kong University of Science and Technology. Accessed January 17, 2021. http://repository.ust.hk/ir/Record/1783.1-81393 ; https://doi.org/10.14711/thesis-b1251887 ; http://repository.ust.hk/ir/bitstream/1783.1-81393/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ko, Wai Lun. “Characterization of corneal biomechanical properties and applications in glaucoma risk assessment.” 2013. Web. 17 Jan 2021.

Vancouver:

Ko WL. Characterization of corneal biomechanical properties and applications in glaucoma risk assessment. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2013. [cited 2021 Jan 17]. Available from: http://repository.ust.hk/ir/Record/1783.1-81393 ; https://doi.org/10.14711/thesis-b1251887 ; http://repository.ust.hk/ir/bitstream/1783.1-81393/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ko WL. Characterization of corneal biomechanical properties and applications in glaucoma risk assessment. [Thesis]. Hong Kong University of Science and Technology; 2013. Available from: http://repository.ust.hk/ir/Record/1783.1-81393 ; https://doi.org/10.14711/thesis-b1251887 ; http://repository.ust.hk/ir/bitstream/1783.1-81393/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

9. 傅林. The role of electrical stimulation in ophthalmic disorders.

Degree: 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/240681

► Electrical stimulation therapy, using low-intensity electrical current, is a novel adjuvant therapeutic technique employed in neurodegenerative diseases, including those of the peripheral nervous system, musculoskeletal… (more)

▼ Electrical stimulation therapy, using low-intensity electrical current, is a novel adjuvant therapeutic technique employed in neurodegenerative diseases, including those of the peripheral nervous system, musculoskeletal system, central nervous system as well as in otorhinolaryngology. Recently electrical stimulation therapy has been shown to protect retinal ganglion cells (RGCs) and retinal photoreceptors from secondary degeneration and preserve retinal function in animals and in-vitro models of end-stage ocular diseases. A better understanding of the underlying mechanism to facilitate the application of this treatment in ocular disease especially irreversible visual defect like glaucoma and aging related maculopathy. For my thesis work, I investigated the potential neuroprotective effects of transcorneal electrical stimulation (TcES) in an animal model of acute ocular hypertensive injury as well as the effect of the electrical current on a photoreceptor cell line exposed to hypoxic injury. During the process, I experimented with different rodents, different methods of intraocular pressure elevation in animals and compared electroretinographic responses in animals of different ages to find the optimum model for my work. For the animal study, acute ocular hypertensive injury was induced in the right eye of all gerbils. They were then divided equally into treatment and sham-treatment groups. In the treatment group, TcES was performed to the surgical eye immediately and twice weekly after AOH for 1 week and 1 month respectively. In the sham treatment group, sham TcES was given to the surgical eye at the same time points. TcES treated eyes had significantly higher RGCs survival rate at 1 month compared to the ones received sham treatments. This was associated with improved RGCs function and vision-related behavior. Furthermore TcES treated eyes were shown to have increased IL-10 protein secretion, with a corresponding reduction in IL-6 and COX-2 secretions as well as reduction in NF-kB phosphorylation when assessed by western blot. This was associated with the suppression of microglial cell activation in TcES treated eyes. I conducted an in vitro study to further investigate the potential molecular mechanisms of TcES induced retinal neuroprotection. Chemical hypoxia was induced in separate photoreceptor cell lines and Müller cell lines using cobalt chloride (II) (CoCl2). Electrical stimulation was then applied to the Müller cell line for 1 hour and the conditional medium was collected 3 and 24 h after stimulation. This conditional medium was then added to the hypoxic photoreceptor cell line for 3 and 24 h accordingly. Cell viability of the 661W was then measured and compared by MTS cell proliferation assay. This model however did not demonstrate any significant improvement in photoreceptor cell survival after exposure to the electrical current treated Müller cell-medium. In conclusion, my thesis work demonstrated that TcES treatment successfully rescued RGCs from secondary degeneration after acute ocular hypertensive…

Subjects/Keywords: Eye - Diseases - Treatment

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APA (6^th Edition):

傅林. (2016). The role of electrical stimulation in ophthalmic disorders. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/240681

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

傅林. “The role of electrical stimulation in ophthalmic disorders.” 2016. Thesis, University of Hong Kong. Accessed January 17, 2021. http://hdl.handle.net/10722/240681.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

傅林. “The role of electrical stimulation in ophthalmic disorders.” 2016. Web. 17 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

傅林. The role of electrical stimulation in ophthalmic disorders. [Internet] [Thesis]. University of Hong Kong; 2016. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10722/240681.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

傅林. The role of electrical stimulation in ophthalmic disorders. [Thesis]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/240681

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

10. Voogd, Simone. Incidence and risk factors of open-angle glaucoma : the Rotterdam study.

Degree: 2006, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/76913

► markdownabstract__Abstract__ Glaucoma is one of the poorest understood and defined eye diseases among those known since our era. Despite two millennia of writing about glaucoma,… (more)

Subjects/Keywords: glaucoma; eye diseases

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APA (6^th Edition):

Voogd, S. (2006). Incidence and risk factors of open-angle glaucoma : the Rotterdam study. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/76913

Chicago Manual of Style (16^th Edition):

Voogd, Simone. “Incidence and risk factors of open-angle glaucoma : the Rotterdam study.” 2006. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 17, 2021. http://hdl.handle.net/1765/76913.

MLA Handbook (7^th Edition):

Voogd, Simone. “Incidence and risk factors of open-angle glaucoma : the Rotterdam study.” 2006. Web. 17 Jan 2021.

Vancouver:

Voogd S. Incidence and risk factors of open-angle glaucoma : the Rotterdam study. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2006. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1765/76913.

Council of Science Editors:

Voogd S. Incidence and risk factors of open-angle glaucoma : the Rotterdam study. [Doctoral Dissertation]. Erasmus University Medical Center; 2006. Available from: http://hdl.handle.net/1765/76913

Ryerson University

11. Ramdass, Jermaine. Prediction of Cup-to-Disc Ratio From Optic Fundus Image.

Degree: 2016, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A4972

► A technique is proposed that can be used to predict the cup-to-disc ratio from a single optic fundus image and determine which image features have… (more)

Subjects/Keywords: Ophthalmology – Research – Methodology; Eye – Imaging; Eye – Diseases – Diagnosis; Fundus oculi – Diseases – Diagnosis; Ophthalmic photography

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APA (6^th Edition):

Ramdass, J. (2016). Prediction of Cup-to-Disc Ratio From Optic Fundus Image. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A4972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ramdass, Jermaine. “Prediction of Cup-to-Disc Ratio From Optic Fundus Image.” 2016. Thesis, Ryerson University. Accessed January 17, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A4972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ramdass, Jermaine. “Prediction of Cup-to-Disc Ratio From Optic Fundus Image.” 2016. Web. 17 Jan 2021.

Vancouver:

Ramdass J. Prediction of Cup-to-Disc Ratio From Optic Fundus Image. [Internet] [Thesis]. Ryerson University; 2016. [cited 2021 Jan 17]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A4972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ramdass J. Prediction of Cup-to-Disc Ratio From Optic Fundus Image. [Thesis]. Ryerson University; 2016. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A4972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston

12. Tukler Henriksson, Johanna. Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva.

Degree: PhD, Physiological Optics and Vision Science, 2011, University of Houston

URL: http://hdl.handle.net/10657/431

► Purpose: The young adult mouse has become the preferred animal model in many areas of ophthalmic research. For this reason, there is a need to… (more)

▼ Purpose: The young adult mouse has become the preferred animal model in many areas of ophthalmic research. For this reason, there is a need to validate its use in different experimental settings and to assess its applicability to the human. The purpose of this research was to firstly, evaluate the normal mouse cornea and conjunctiva, secondly to utilize the mouse as an animal model, to investigate structural changes occurring in the dry eye and thirdly to investigate ocular UVR transmittance of this small eye. Methods: A total of 45 animals were utilized for these experiments. Ocular dryness was induced in 16 by administration of scopolamine hydrobromide (0.5mg/0.2ml) QID, and exposure to a dry environment for 5 (DS5) or 10 (DS10) days. After euthanization the corneas or eye lids were fixed either in 2% glutaraldehyde and processed according to an established histology protocol for light- (LM) and transmission electron microscopy (TEM) or in 10% formalin and embedded in paraffin. Counts or measurements were obtained utilizing well defined specific reference points allowing the observer to conduct accurate and repeatable intra-corneal or intra-conjunctival measurements. Goblet cell density was investigated both on resin and paraffin embedded tissues with a variety stains and histological protocols. UVR transmittance of the whole mouse eye, the cornea and the crystalline lens was also investigated. Immediately after euthanization the mouse eye was placed under a 0.2 mm diameter detecting fiber optic illuminated by an Oceans Optics deuterium/halogen source (DT-MINI-2-GS). The data were recorded and analyzed with an Ocean Optics spectrometer (USB4000) and analyzed in Matlab. Results: The mouse epithelium contributed to 1/3 and the stroma to 2/3 of the total corneal thickness. A statistically significant (P < 0.001) decrease in overall thickness was found in the periphery compared to the center. The central cornea had an average of 50 ± 2 lamellae with an average thickness of 2.1 µm versus 36 ± 3 and 1.8 µm peripherally (P < 0.005). The mouse did not possess an anterior limiting lamina (ALL). Near the junction between the lid margin and the normal palpebral conjunctiva the epithelium had an average thickness of 46 ± 11 µm and 9 ± 2 cell layers, versus 42 ± 7 µm and 8 ± 1 layers in the DS5 (P > 0.05) and 38 ± 6 µm and 7 ± 1 layers in the DS10 (P < 0.05). In the goblet cell populated palpebral region the normal conjunctival epithelium averaged 24 ± 4 µm and was significantly (P < 0.05) thicker than in the DS5 (18 ± 3 µm) and the DS10 (19 ± 3 µm). In the control 43% of the goblet cells had epithelial coverage, compared to 58% for the DS5 and 63% for the DS10 (P < 0.05). Some stains indicated a decreased number of goblet cells in the dry eye (PAS and Alcian blue), while (MUC5AC, histology) did not. The mouse had a UVR transmittance cut off at 280 nm for the cornea and 310 nm for the crystalline lens. 50% absorption of UVR was achieved at 330 nm and 375 nm by the cornea and crystalline lens respectively.… Advisors/Committee Members: Bergmanson, Jan P. (advisor), Gierow, Peter J. (committee member), McDermott, Alison M. (committee member), Miller, William L. (committee member), Pflugfelder, Stephen C. (committee member).

Subjects/Keywords: Mouse corneal dimensions; Dry eye diseases; Palpebral conjunctiva; UVR transmittance of the mouse eye; Mice – Sense organs; Eye – Diseases – Animal models

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APA (6^th Edition):

Tukler Henriksson, J. (2011). Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/431

Chicago Manual of Style (16^th Edition):

Tukler Henriksson, Johanna. “Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva.” 2011. Doctoral Dissertation, University of Houston. Accessed January 17, 2021. http://hdl.handle.net/10657/431.

MLA Handbook (7^th Edition):

Tukler Henriksson, Johanna. “Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva.” 2011. Web. 17 Jan 2021.

Vancouver:

Tukler Henriksson J. Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva. [Internet] [Doctoral dissertation]. University of Houston; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10657/431.

Council of Science Editors:

Tukler Henriksson J. Validating the Mouse Model for Ocular Surface Reserach and Assessing Morphological Changes in the Dry Eye Palpebral Conjunctiva. [Doctoral Dissertation]. University of Houston; 2011. Available from: http://hdl.handle.net/10657/431

Michigan State University

13. Edelhauser, Henry Francis, 1937-. In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri.

Degree: MS, Dept. of Physiology, 1964, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:10521

Subjects/Keywords: Trout – Diseases; Eye – Diseases

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APA (6^th Edition):

Edelhauser, Henry Francis, 1. (1964). In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:10521

Chicago Manual of Style (16^th Edition):

Edelhauser, Henry Francis, 1937-. “In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri.” 1964. Masters Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:10521.

MLA Handbook (7^th Edition):

Edelhauser, Henry Francis, 1937-. “In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri.” 1964. Web. 17 Jan 2021.

Vancouver:

Edelhauser, Henry Francis 1. In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri. [Internet] [Masters thesis]. Michigan State University; 1964. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:10521.

Council of Science Editors:

Edelhauser, Henry Francis 1. In vitro corneal ion and water movement in the rainbow trout, Salmo gairdneri. [Masters Thesis]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:10521

University of Missouri – Kansas City

14. Patel, Sulabh P. Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases.

Degree: PhD, 2013, University of Missouri – Kansas City

URL: http://hdl.handle.net/10355/47465

► We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and… (more)

▼ We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB copolymers with different composition, molecular weights and block arrangements were utilized to develop protein-embedded thermosensitive gels or nanoparticles (NPs) for sustained delivery in the treatment of posterior segment ocular diseases. In order to eliminate the burst release effect, we have studied PB composite formulation comprised of protein-encapsulated PB NPs dispersed in PB thermosensitive gel. The composite formulation eliminated burst release effect and exhibited nearly zero-order protein release for significantly longer durations. In this research work, we have utilized various model proteins (lysozyme, IgG-Fab, IgG, BSA, and catalase) and therapeutic proteins (octreotide, insulin and bevacizumab) to optimize the formulation. We have synthesized various triblock (TB) (PCL-PEG-PCL, B-A-B) and PB (PLA-PCL-PEG-PCL-PLA (C-B-A-B-C) and PEG-PCL-PLA-PCL-PEG (A-B-C-B-A)) copolymers based thermosensitive gelling polymers. We have observed distinct effect of block arrangement and molecular weights of block copolymers on the sol-gel transition and on the kinematic viscosity of aqueous solutions. PB copolymers with A-B-C-B-A block arrangement exhibited significantly lower viscosity relative to TB copolymers or other types of PB copolymers (C-B-A-B-C). The difference in viscosity and sol-gel transition behavior has been explained by two different processes of micellization for A-B-C-B-A and B-A-B, or C-B-A-B-C types of copolymers. Moreover, a PB copolymer based formulation sustained the release of IgG up to ~20 days, which is significantly longer relative to TB copolymers based formulations. In order to sustain release for longer duration, we have synthesized various PB copolymers (PLA-PCL-PEG-PCL-PLA and PGA-PCL-PEG-PCL-PGA) with high molecular weight and utilized them for the fabrication of protein-encapsulated NPs. We observed a significant effect of the presence of PLA or PGA on entrapment efficiency (EE), drug loading (DL) and in vitro release behavior. This may be due to the fact that PB copolymers exhibited significantly reduced crystallinity relative to TB copolymers. In addition, we have successfully optimized NP preparation methods to achieve maximum possible DL. This achievement allowed the loading of a large amount of drug which can last for ~6 month in a limited injection volume (100 μL). The optimized methods were successfully utilized to encapsulate a wide variety of peptides and proteins with molecular weights ranging from 1 - 237 kDa in PB NPs. PB NPs alone exhibited significant burst release in the first few days of release study. However, a composite formulation comprised of protein-encapsulated PB-NPs prepared with optimized method and optimized PB copolymers (PB copolymers for NPs and thermosensitive gel) exhibited protein release for significantly longer duration of time… Advisors/Committee Members: Mitra, Ashim K., 1954- (advisor).

Subjects/Keywords: Eye – Diseases – Research.; Eye – Diseases – Treatment; Dissertation – University of Missouri – Kansas City – Pharmacy; Dissertation – University of Missouri – Kansas City – Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, S. P. (2013). Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases. (Doctoral Dissertation). University of Missouri – Kansas City. Retrieved from http://hdl.handle.net/10355/47465

Chicago Manual of Style (16^th Edition):

Patel, Sulabh P. “Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases.” 2013. Doctoral Dissertation, University of Missouri – Kansas City. Accessed January 17, 2021. http://hdl.handle.net/10355/47465.

MLA Handbook (7^th Edition):

Patel, Sulabh P. “Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases.” 2013. Web. 17 Jan 2021.

Vancouver:

Patel SP. Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases. [Internet] [Doctoral dissertation]. University of Missouri – Kansas City; 2013. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10355/47465.

Council of Science Editors:

Patel SP. Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases. [Doctoral Dissertation]. University of Missouri – Kansas City; 2013. Available from: http://hdl.handle.net/10355/47465

University of Missouri – Kansas City

15. Markham, Jessica Lynn. Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis.

Degree: 2017, University of Missouri – Kansas City

URL: http://hdl.handle.net/10355/64171

► Purpose/Objectives Orbital cellulitis is an infection of the orbit that can lead to rare, but life-altering complications. Previous studies have suggested that corticosteroids may improve… (more)

▼ Purpose/Objectives Orbital cellulitis is an infection of the orbit that can lead to rare, but life-altering complications. Previous studies have suggested that corticosteroids may improve recovery in patients with orbital cellulitis. However, no large, multicenter studies have examined the use of systemic corticosteroids in children with orbital cellulitis. The objectives of this current study are to describe systemic corticosteroid use and associated outcomes in a national cohort of children hospitalized with orbital cellulitis. Design/Methods Using the Pediatric Health Information System, we performed a retrospective cohort analysis of children aged 2 months to 18 years old hospitalized with orbital cellulitis from 2007 to 2014. Propensity score matching was performed to match children with orbital cellulitis who did or did not receive systemic corticosteroids on relevant clinical and demographic factors. Post-propensity score comparisons were performed using generalized linear mixed-effects or conditional logistic regression modeling to assess for differences in outcomes including length of stay (LOS), cost, intensive care unit (ICU) transfer, emergency department (ED) revisits, and hospital readmissions between children who did or did not receive corticosteroids. Results Of 2,963 children hospitalized with orbital cellulitis who met inclusion criteria, 587 (19.8 %) received systemic corticosteroids. In the matched cohort, there were 1,072 children (536 pairs) representing 41 hospitals. In the matched cohort, the LOS (Adjusted Rate Ratio (95 % CI): 1.08 (0.95-1.22), p=0.265) were similar but the costs were higher (1.21 (1.06 1.37), p=0.004) in children who received corticosteroids compared with those who did not receive corticosteroids. Although not statistically significant, we observed a trend of higher rates of 14- and 30-day readmissions among children receiving corticosteroids compared to children who did not receive corticosteroids. Conclusions In this large multicenter study, children with orbital cellulitis who received systemic corticosteroids had higher costs, but similar LOS. Additionally, we observed a trend toward increased rates of readmissions among children who received systemic corticosteroids. Our findings suggest that systemic corticosteroids may not significantly improve recovery in children with orbital cellulitis. Future prospective studies are needed to more fully assess the risks and benefits of utilizing systemic corticosteroids in the management of children with orbital cellulitis. Advisors/Committee Members: Gerkovich, Mary M., 1950- (advisor).

Subjects/Keywords: Cellulitis; Eye – Diseases; Adrenocortical hormones; Cellulitis; Eye Diseases; Adrenal Cortex Hormones; Thesis – University of Missouri – Kansas City – Medicine

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APA (6^th Edition):

Markham, J. L. (2017). Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis. (Thesis). University of Missouri – Kansas City. Retrieved from http://hdl.handle.net/10355/64171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Markham, Jessica Lynn. “Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis.” 2017. Thesis, University of Missouri – Kansas City. Accessed January 17, 2021. http://hdl.handle.net/10355/64171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Markham, Jessica Lynn. “Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis.” 2017. Web. 17 Jan 2021.

Vancouver:

Markham JL. Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis. [Internet] [Thesis]. University of Missouri – Kansas City; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10355/64171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Markham JL. Evaluation of the Role of Adjunctive Corticosteroids in the Management of Children Hospitalized with Orbital Cellulitis. [Thesis]. University of Missouri – Kansas City; 2017. Available from: http://hdl.handle.net/10355/64171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

16. Occelli, Laurence Mireille Alice. Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies.

Degree: 2017, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:6723

►

Leber’s congenital amaurosis (LCA) is one of the major inherited causes of childhood blindness. Mutations in the cone-rod homeobox (CRX) gene result in severe dominant… (more)

▼

Leber’s congenital amaurosis (LCA) is one of the major inherited causes of childhood blindness. Mutations in the cone-rod homeobox (CRX) gene result in severe dominant retinopathies and can be responsible for LCA. CRX is a transcription factor essential for normal photoreceptor development and survival. The CrxRdy cat has a spontaneous frameshift mutation in Crx and represents a model for Class III CRX mutations where the mutant CRX allele binds DNA but fails to transactivate it. The CrxRdy cat model is valuable for investigating disease mechanisms as well as potential therapy development. In this model, early disease stages in the heterozygous cat (CrxRdy/+) mimic severe Leber’s congenital amaurosis. This is characterized by a dominant negative effect of the mutant Crx mRNA/protein over the wild-type mRNA/protein. This study fully investigated the early phenotype as well as the timing and extent of retinal remodeling during retinal degeneration. There is early halting of photoreceptor development coupled with over expression of the mutant Crx allele, accumulation of abnormally high mutant Crx protein levels, resulting in markedly impaired visual function followed by retinal degeneration. During the late stages of the disease, extensive inner retinal remodeling occurred with some retinal pigmentary epithelium (RPE) degeneration in the area centralis (macula-like high retinal acuity region of the feline retina) and also vascular remodeling. The homozygous cat (CrxRdy/Rdy) had a different phenotype with halting of photoreceptor development at an earlier stage resulting in complete blindness and total lack of photoreceptor function. This was followed by a slower photoreceptor degeneration and extensive retinal remodeling that differed from that of the heterozygote cat. Additionally, there was a marked increase in globe size with a severe alteration in refraction. There is currently no treatment for dominant negative LCA diseases. Yet, the investigation findings on CrxRdy/+ cat model and the similarities between the feline eye and the human eye with the presence of a macula-like region make this feline model valuable for preclinical testing of therapies for dominant CRX diseases. The detailed phenotyping sheds light on the therapeutic approach needed. Prior to photoreceptor degeneration, a therapeutic approach aiming to restore function to endogenous photoreceptors would need to increase the expression levels of the wild-type allele over the mutant transcript. Following photoreceptor degeneration, therapeutic approaches to replace photoreceptors or to activate light-induced responses in other retinal neurons would need to be performed before retinal remodeling and neuronal cell loss become too extensive. Trial therapy using a gene augmentation approach showed some promise to improve the phenotype but requires further optimization.The CrxRdy cat is a valuable model for Class III CRX mutations, RPE degeneration and deprivation myopia mechanism, and therapy development.

Online resource;

Advisors/Committee Members: Petersen-Jones, Simon M, Komaromy, Andras M, Kruger, John, Thompson, Debra A.

Subjects/Keywords: Eye – Diseases – Genetic aspects; Eye – Diseases – Animal models; Pediatric ophthalmology – Research; Transcription factors; Veterinary science; Ophthalmology; Biology

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APA (6^th Edition):

Occelli, L. M. A. (2017). Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:6723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Occelli, Laurence Mireille Alice. “Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies.” 2017. Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:6723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Occelli, Laurence Mireille Alice. “Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies.” 2017. Web. 17 Jan 2021.

Vancouver:

Occelli LMA. Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies. [Internet] [Thesis]. Michigan State University; 2017. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:6723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Occelli LMA. Phenotypic, cellular and molecular characterization of the CRX-LCA feline model and potential therapies. [Thesis]. Michigan State University; 2017. Available from: http://etd.lib.msu.edu/islandora/object/etd:6723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

17. Annear, Matthew. Investigating outcomes of gene replacement therapy in the RPE65-deficient dog.

Degree: 2012, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:725

►

Thesis M.S. Michigan State University. Comparative Medicine and Integrative Biology 2012.

Treatment of Leber Congenital Amaurosis (LCA) caused by RPE65 gene mutations with recombinant adeno-associated… (more)

Subjects/Keywords: Retinal degeneration – Gene therapy; Eye – Diseases – Genetic aspects; Dogs – Diseases – Genetic aspects; Veterinary medicine

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APA (6^th Edition):

Annear, M. (2012). Investigating outcomes of gene replacement therapy in the RPE65-deficient dog. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:725

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Annear, Matthew. “Investigating outcomes of gene replacement therapy in the RPE65-deficient dog.” 2012. Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:725.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Annear, Matthew. “Investigating outcomes of gene replacement therapy in the RPE65-deficient dog.” 2012. Web. 17 Jan 2021.

Vancouver:

Annear M. Investigating outcomes of gene replacement therapy in the RPE65-deficient dog. [Internet] [Thesis]. Michigan State University; 2012. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:725.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Annear M. Investigating outcomes of gene replacement therapy in the RPE65-deficient dog. [Thesis]. Michigan State University; 2012. Available from: http://etd.lib.msu.edu/islandora/object/etd:725

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

18. Tsai, Hsiang-Rong. Establishing canine trabecular meshwork cell culture.

Degree: 2016, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:4114

►

Thesis M.S. Michigan State University. Physiology 2016

Glaucoma is a leading cause of incurable blindness. The most common form of glaucoma is primary open-angle glaucoma… (more)

Subjects/Keywords: Glaucoma; Dogs – Diseases; Intraocular pressure; Open-angle glaucoma – Pathogenesis; Eye – Diseases – Pathogenesis; Physiology; Ophthalmology

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APA (6^th Edition):

Tsai, H. (2016). Establishing canine trabecular meshwork cell culture. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tsai, Hsiang-Rong. “Establishing canine trabecular meshwork cell culture.” 2016. Thesis, Michigan State University. Accessed January 17, 2021. http://etd.lib.msu.edu/islandora/object/etd:4114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tsai, Hsiang-Rong. “Establishing canine trabecular meshwork cell culture.” 2016. Web. 17 Jan 2021.

Vancouver:

Tsai H. Establishing canine trabecular meshwork cell culture. [Internet] [Thesis]. Michigan State University; 2016. [cited 2021 Jan 17]. Available from: http://etd.lib.msu.edu/islandora/object/etd:4114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tsai H. Establishing canine trabecular meshwork cell culture. [Thesis]. Michigan State University; 2016. Available from: http://etd.lib.msu.edu/islandora/object/etd:4114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

19. Orwig, Susan D. Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease.

Degree: PhD, Chemistry and Biochemistry, 2011, Georgia Tech

URL: http://hdl.handle.net/1853/45816

► The inherited form of primary open angle glaucoma, a disorder characterized by increased intraocular pressure and retina degeneration, is linked to mutations in the olfactomedin… (more)

▼ The inherited form of primary open angle glaucoma, a disorder characterized by increased intraocular pressure and retina degeneration, is linked to mutations in the olfactomedin (OLF) domain of the myocilin gene. Disease-causing myocilin variants accumulate within trabecular meshwork cells instead of being secreted to the trabecular extracellular matrix thought to regulate aqueous humor flow and control intraocular pressure. Like other diseases of protein misfolding, we hypothesize myocilin toxicity originates from defects in protein biophysical properties. In this thesis, the first preparative recombinant high-yield expression and purification system for the C-terminal OLF domain of myocilin (myoc-OLF) is described. To determine the relative stability of wild-type (WT) and mutant OLF domains, a fluorescence thermal stability assay was adapted to provide the first direct evidence that mutated OLF is folded but less thermally stable than WT. In addition, mutant myocilin can be stabilized by chemical chaperones. Together, this work provides the first quantitative demonstration of compromised stability among identified OLF variants and placing myocilin glaucoma in the context of other complex diseases of protein misfolding. Subsequent investigations into the biophysical properties of WT myoc-OLF provide insight into its structure and function. In particular, myoc-OLF is stable in the presence of glycosaminoglycans (GAGs), as well as over a wide pH range in buffers with functional groups reminiscent of such GAGs. Myoc-OLF contains significant â-sheet and â-turn secondary structure as revealed by circular dichroism analysis. At neutral pH, thermal melts indicate a highly cooperative transition with a melting temperature of ~55°C. A compact core structural domain of OLF was identified by limited proteolysis and consists of approximately residues 238-461, which retains the single disulfide bond and is as stable as the full myoc-OLF construct. This construct also is capable of generating 3D crystals for structure determination. This data, presented in Chapter 3, inform new testable hypotheses for interactions with specific trabecular extracellular matrix components. To gain further insight into the biological function of myoc-OLF, a facile fluorescence chemical stability assay was designed to identify possible ligands and drug candidates. In the assay described in Chapter 4, the target protein is initially destabilized with a chemical denaturant and is tested for re-stabilization upon the addition of small molecules. The assay requires no prior knowledge of the structure and/or function of the target protein, and it is amendable to high-throughput screening. Application of the assay using a library of 1,280 compounds revealed 14 possible ligands and drug candidates for myoc-OLF that may also generate insights into myoc-OLF function. Due to the high â-sheet content of monomeric myoc-OLF and presence of an aggregated species upon myoc-OLF purification, the ability of myoc-OLF to form amyloid fibrils was suspected and… Advisors/Committee Members: Dr. Raquel Lieberman (Committee Chair), Dr. A. (Yomi) Oyelere (Committee Member), Dr. Al Merril (Committee Member), Dr. Loren Williams (Committee Member), Dr. Nicholas Hud (Committee Member), Dr. Roger Wartell (Committee Member).

Subjects/Keywords: Open-angle glaucoma; Pharmacological chaperones; High-throughput drug screen; Amyloid fibrils; Gaucher disease; Myocilin; Glaucoma; Eye Diseases; Eye Diseases Genetic aspects; Intraocular pressure; Body fluids Pressure; Eye

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Orwig, S. D. (2011). Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/45816

Chicago Manual of Style (16^th Edition):

Orwig, Susan D. “Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease.” 2011. Doctoral Dissertation, Georgia Tech. Accessed January 17, 2021. http://hdl.handle.net/1853/45816.

MLA Handbook (7^th Edition):

Orwig, Susan D. “Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease.” 2011. Web. 17 Jan 2021.

Vancouver:

Orwig SD. Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease. [Internet] [Doctoral dissertation]. Georgia Tech; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1853/45816.

Council of Science Editors:

Orwig SD. Biophysical and structural characterization of proteins implicated in glaucoma and Gaucher disease. [Doctoral Dissertation]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/45816

Columbia University

20. Tsai, Yi-Ting. Therapy and mechanism of Mendelian eye diseases.

Degree: 2018, Columbia University

URL: https://doi.org/10.7916/D8K37BHV

► Retinal degenerative diseases cause varying degrees of irreversible vision loss in millions of people worldwide. Common to all retinal degenerative diseases is the malfunction or… (more)

▼ Retinal degenerative diseases cause varying degrees of irreversible vision loss in millions of people worldwide. Common to all retinal degenerative diseases is the malfunction or demise of photoreceptor cells or its supportive cells, retinal pigment epithelium cell in the retina. A considerable part of these diseases were resulted from the inherited mutations of essential genes expressed in these retinal cells. The understanding of pathologic mechanism as well as developing of therapeutic treatment for these diseases were discussed in this study. A cutting-edge therapeutic genome editing technology is studied in the first part of study. This technology was invented to treat retinitis pigmentosa via engineered nucleases, which has great clinical potential for autosomal dominant genetic disorders that were previously irreparable by conventional gene therapy interventions. Though customizable gene editing tools can be engineered to target specific mutation sites, however it is too daunting for diseases like retinitis pigmentosa, a progressive retinal degenerative condition associated with more than 150 mutations in the rhodopsin gene alone. Here in this study, we present an “ablate-and-replace” combination strategy that 1) destroys expression of the endogenous gene by CRISPR/Cas9 in a mutation-independent manner, and 2) enables expression of wild-type protein through exogenous cDNA. As proof of concept, we show that our CRISPR-based therapeutic machinery efficiently ablates mRho in vivo, and when combined with gene replacement therapy, ameliorates rod photoreceptor degeneration and improves visual function in two genetically distinct autosomal dominant retinitis pigmentosa animal models. This mutation-independent, ablate-and-replace strategy represents the first electrophysiological recovery by a CRISPR-mediated therapy in an autosomal dominant disorder and it offers a clinically relevant, universal strategy to overcome allelic heterogeneity in debilitating inherited conditions. For the second part of the study, gene editing technology was used to study the pathogenesis of Doyne honey comb dystrophy, another Mendelian disease with extensive similarities to age-related macular degeneration. This monogenic disorder is caused by a unique point mutation on an extracellular matrix protein EFEMP1, expressed by retinal pigment epithelium cell. To precisely gauge the physiological effect resulted from this mutation, CRISPR-mediated gene correction was used to create isogeneic cell pairs from patient donated tissue-derived stem cells. These stem cells were differentiated into retinal pigment epithelium cell before analysis. We found unfolded protein response and immune response were not involved in the pathogenesis, which contradicts existing theories. Via proteomics analysis, we found expression level of a cholesterol catabolic enzyme was affected by the EFEMP1 mutation while those proteins controlling the cholesterol transport remains constant. This result provides supportive evidence to explain the aberrant…

Subjects/Keywords: Genetics; Biomedical engineering; Retinal degeneration; Eye – Diseases – Treatment; Therapeutics

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APA (6^th Edition):

Tsai, Y. (2018). Therapy and mechanism of Mendelian eye diseases. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8K37BHV

Chicago Manual of Style (16^th Edition):

Tsai, Yi-Ting. “Therapy and mechanism of Mendelian eye diseases.” 2018. Doctoral Dissertation, Columbia University. Accessed January 17, 2021. https://doi.org/10.7916/D8K37BHV.

MLA Handbook (7^th Edition):

Tsai, Yi-Ting. “Therapy and mechanism of Mendelian eye diseases.” 2018. Web. 17 Jan 2021.

Vancouver:

Tsai Y. Therapy and mechanism of Mendelian eye diseases. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2021 Jan 17]. Available from: https://doi.org/10.7916/D8K37BHV.

Council of Science Editors:

Tsai Y. Therapy and mechanism of Mendelian eye diseases. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8K37BHV

Hong Kong University of Science and Technology

21. Yu, Yu. Engineering ocular drug delivery system for posterior eye diseases.

Degree: 2014, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-62755 ; https://doi.org/10.14711/thesis-b1274121 ; http://repository.ust.hk/ir/bitstream/1783.1-62755/1/th_redirect.html

► Ocular neovascularization diseases including age-related macular degeneration are the leading causes of blindness in developing countries. Because of the chronic nature of the disease and… (more)

▼ Ocular neovascularization diseases including age-related macular degeneration are the leading causes of blindness in developing countries. Because of the chronic nature of the disease and the fast elimination of drug in the eye, monthly repeated intravitreal injection are required to achieve best therapeutic outcome. However, repeated intravitreal injection increases the risk of developing ocular complications and decreases the patient compliance. In this thesis, an injectable chemically crosslinked hydrogel formulation of an anti-VEGF antibody therapeutic for eye diseases was developed and evaluated in vitro and in vivo. We demonstrated for the first time that the prolonged release of protein therapeutics can be achieved in the eye for at least 6 months. Different from previous attempts of using physical hydrogel, chemically crosslinking between polymer precursors was designed as the gelation method. Vinylsulfone-thiol reaction pair was chosen for its fast reaction kinetics in physiological condition and biocompatibility. To modify polymers to contain vinylsulfone groups or thiol groups, we introduced simple “click” chemistry based reactions which was applicable to a majority of hydroxyl-containing water soluble polymers including hyaluronic acid, dextran, PVA and alginate with controllable degree of modification. The development of these simple reactions provided us with wide varieties of starting materials for formulation optimization. To enable rational design of formulations for our application, we developed a simple model based on De Gennes’ Blob Theory to understand hydrogel formation from crosslinking polymer solution. By estimating hydrogel as a semidilute solution fixed at entanglement points, the relation between polymer properties and hydrogel properties was evaluated from theoretical perspectives and validated using experiments. From this model, we can calculate minimum gelation concentration and estimate hydrogel mesh size based solely on polymer parameters such as molecular weight and radius of gyration. The model also sheds new insights on the effect of crosslinker density or degree of modification on hydrogel’s mechanical properties and mesh size. Based on this model, we controlled the mesh size of hydrogel and minimize the undesirable protein binding between protein and with hydrogel material, and successfully developed an in situ hyaluronic acid/dextran based hydrogel capable of releasing the model therapeutic protein, Avastin®, for at least 3 months in vitro with tunable release rate. The biocompatibility and in vivo release of one formulation was evaluated in rabbit eye. The intraocular pressure (IOP) measurement, fundus morphology observation using binocular indirect ophthalmoscope (BIO), electroretinogram (ERG) and histology showed that the gel was well tolerated. Avastin® was released continuously from the gel formulation and maintained above therapeutically relevant concentration in the vitreous for least 6 months.

Subjects/Keywords: Colloids ; Protein drugs ; Eye ; Diseases ; Treatment ; Drug delivery systems

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APA (6^th Edition):

Yu, Y. (2014). Engineering ocular drug delivery system for posterior eye diseases. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-62755 ; https://doi.org/10.14711/thesis-b1274121 ; http://repository.ust.hk/ir/bitstream/1783.1-62755/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yu, Yu. “Engineering ocular drug delivery system for posterior eye diseases.” 2014. Thesis, Hong Kong University of Science and Technology. Accessed January 17, 2021. http://repository.ust.hk/ir/Record/1783.1-62755 ; https://doi.org/10.14711/thesis-b1274121 ; http://repository.ust.hk/ir/bitstream/1783.1-62755/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yu, Yu. “Engineering ocular drug delivery system for posterior eye diseases.” 2014. Web. 17 Jan 2021.

Vancouver:

Yu Y. Engineering ocular drug delivery system for posterior eye diseases. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2014. [cited 2021 Jan 17]. Available from: http://repository.ust.hk/ir/Record/1783.1-62755 ; https://doi.org/10.14711/thesis-b1274121 ; http://repository.ust.hk/ir/bitstream/1783.1-62755/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu Y. Engineering ocular drug delivery system for posterior eye diseases. [Thesis]. Hong Kong University of Science and Technology; 2014. Available from: http://repository.ust.hk/ir/Record/1783.1-62755 ; https://doi.org/10.14711/thesis-b1274121 ; http://repository.ust.hk/ir/bitstream/1783.1-62755/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

22. Carbe, Christian J. GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT.

Degree: 2011, IUPUI

URL: http://hdl.handle.net/1805/2605

►

Indiana University-Purdue University Indianapolis (IUPUI)

Aniridia, a congenital ocular disorder caused by haploinsufficiency of transcription factor PAX6, is characterized by complete or partial iris hypoplasia… (more)

▼

Indiana University-Purdue University Indianapolis (IUPUI)

Aniridia, a congenital ocular disorder caused by haploinsufficiency of transcription factor PAX6, is characterized by complete or partial iris hypoplasia with associated foveal hypoplasia. Brain imaging performed in patients heterozygous for PAX6 mutations often reveal absence of the brain anterior or posterior commissure, absence of the pineal gland, and a present but reduced in size corpus callosum. Renal coloboma syndrome, another autosomal dominant inherited disease, is characterized by hypodysplastic kidneys and optic nerve defects, and is caused by haploinsufficiency of transcription factor PAX2. In the first part of this thesis we investigated the role of these Pax genes in neural development, by generating an allelic series of knock-in models at the Pax6 locus. We showed that Pax6(5a) and Pax2 could not replace Pax6 for its auto-regulation in lens induction or for neural differentiation in retina. In brain development, however, we demonstrated that cell proliferation in the cerebral cortex and dorsoventral patterning of the telencephalon and neural tube was partially rescued in either knock-in mutant. We believe our novel findings not only reveal Pax-protein functional specificity during neural development, but may also be utilized to understand the aberrant molecular mechanism that result in aniridia and/or renal coloboma syndrome. Aphakia (lack of lens) is a rare human congenital disorder with its genetic etiology largely unknown. In the second part of this thesis, we show that homozygous deletion of Nf1, the Ras GTPase gene underlying human neurofibromatosis type 1 syndrome, caused lens dysgenesis in mouse. While early lens specification proceeded normally in Nf1 mutants, lens induction was disrupted due to deficient cell proliferation. Further analysis showed that ERK signaling was initially elevated in invaginating lens placode, but by lens vesicle stage, Ras signaling antagonist Sprouty2 was up regulated, followed by rapid decrease in ERK phosphorylation. Only after intraperitoneal treatment of U0126, an inhibitor of ERK phosphorylation, was lens development restored in Nf1 mutants. Hyperactive RAS-MAPK signaling is known to cause neuro-cardiofacial-cutaneous (NCFC) syndromes in human. As a member of NCFC family genes, Nf1 represents the first example that attenuation of Ras-MAPK kinase signaling pathway is essential for normal lens development.

Advisors/Committee Members: Zhang, Xin, White, Kenneth E., Firulli, Anthony B., Thurmond, Debbie C..

Subjects/Keywords: Eye – Diseases – Genetic aspects; Transcription factors; Genes – Regulation; Brain – Imaging

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APA (6^th Edition):

Carbe, C. J. (2011). GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/2605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carbe, Christian J. “GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT.” 2011. Thesis, IUPUI. Accessed January 17, 2021. http://hdl.handle.net/1805/2605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carbe, Christian J. “GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT.” 2011. Web. 17 Jan 2021.

Vancouver:

Carbe CJ. GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT. [Internet] [Thesis]. IUPUI; 2011. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1805/2605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carbe CJ. GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT. [Thesis]. IUPUI; 2011. Available from: http://hdl.handle.net/1805/2605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

23. Bakina, Olga. Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure.

Degree: MS, 2016, Florida Atlantic University

URL: http://purl.flvc.org/fau/fd/FA00004568

►

Summary: The lens is a crystallin tissue of the anterior part of the eye that focuses light onto the retina. Aged-related cataract, which is the… (more)

Subjects/Keywords: Eye x Diseases – Research.; Retinal degeneration.; Cellular control mechanisms.; Apoptosis

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APA (6^th Edition):

Bakina, O. (2016). Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004568

Chicago Manual of Style (16^th Edition):

Bakina, Olga. “Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure.” 2016. Masters Thesis, Florida Atlantic University. Accessed January 17, 2021. http://purl.flvc.org/fau/fd/FA00004568.

MLA Handbook (7^th Edition):

Bakina, Olga. “Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure.” 2016. Web. 17 Jan 2021.

Vancouver:

Bakina O. Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure. [Internet] [Masters thesis]. Florida Atlantic University; 2016. [cited 2021 Jan 17]. Available from: http://purl.flvc.org/fau/fd/FA00004568.

Council of Science Editors:

Bakina O. Integrin αVβ5-mediated Removal Of Apoptotic Cell Debris By The Eye Lens And Its Inhibition By UV-light Exposure. [Masters Thesis]. Florida Atlantic University; 2016. Available from: http://purl.flvc.org/fau/fd/FA00004568

Montana State University

24. Lewis, Amy Sarah. Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program.

Degree: M Nursing, College of Nursing, 1999, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/11353

Subjects/Keywords: Eye.; Diseases.; Nursing Practice.

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APA (6^th Edition):

Lewis, A. S. (1999). Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/11353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lewis, Amy Sarah. “Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program.” 1999. Thesis, Montana State University. Accessed January 17, 2021. https://scholarworks.montana.edu/xmlui/handle/1/11353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lewis, Amy Sarah. “Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program.” 1999. Web. 17 Jan 2021.

Vancouver:

Lewis AS. Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program. [Internet] [Thesis]. Montana State University; 1999. [cited 2021 Jan 17]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/11353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis AS. Macular degeneration, glaucoma, and diabetic retinopathy : a continuing education program. [Thesis]. Montana State University; 1999. Available from: https://scholarworks.montana.edu/xmlui/handle/1/11353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Williamson, Lauren M. Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo.

Degree: Thesis (M.S.), 2015, Ball State University

URL: http://cardinalscholar.bsu.edu/handle/123456789/199583

► Bacillus cereus is a Gram-positive, pathogenic bacterium capable of causing an ocular infection known as endophthalmitis. The virulence of B. cereus during endophthalmitis is largely… (more)

▼ Bacillus cereus is a Gram-positive, pathogenic bacterium capable of causing an ocular infection known as endophthalmitis. The virulence of B. cereus during endophthalmitis is largely attributed to the presence of toxins such as Hbl and Nhe. Although broad-spectrum antibiotics such as vancomycin are able to control B. cereus in the eye during infection, these antibiotics can be toxic to sensitive retinal cells, and they do not control the damaging inflammatory response mounted by the host. Carvacrol is an extract from oregano oil with both antimicrobial and anti-inflammatory qualities that may serve as a possible alternative treatment for B. cereus endophthalmitis. However, at subinhibitory levels, carvacrol increases the virulence of B. cereus. We hypothesize that B. cereus exposed to subinhibitory carvacrol concentrations will cause more damage to the eye than the bacteria alone without progressing into a systemic infection in an in vivo mouse model. Systemic pro-inflammatory cytokines (TNF-α and IL-6) and anti-B. cereus IgG levels were measured by enzyme-linked immunosorbent assays. We found that mice infected with B. cereus and the subinhibitory concentration (SIC) of carvacrol had higher systemic levels of TNF-α, IL-6, and anti-B. cereus IgG. Ocular damage caused by infection with B. cereus was quantified by histological analysis. We found that eyes infected with B. cereus stressed with the SIC of carvacrol had more damage than eyes infected with the bacteria alone. However, ocular damage was not significantly different in mice treated with B. cereus stressed with the SIC of carvacrol and mice treated with the SIC of carvacrol alone. We determined that endophthalmitis caused by B. cereus stressed with the SIC of carvacrol results in an increased systemic immune response and increased ocular damage, but we are unable to confirm if these increases are due to bacterial virulence or irritation caused by carvacrol. Future studies will investigate the effects of carvacrol on retinal pigment epithelial (RPE) cells found in the blood-retinal barrier. Advisors/Committee Members: McKillip, John L. (advisor).

Subjects/Keywords: Carvacrol – Therapeutic use.; Bacillus cereus.; Bacterial diseases – Treatment.; Eye – Inflammation – Treatment.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Williamson, L. M. (2015). Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo. (Masters Thesis). Ball State University. Retrieved from http://cardinalscholar.bsu.edu/handle/123456789/199583

Chicago Manual of Style (16^th Edition):

Williamson, Lauren M. “Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo.” 2015. Masters Thesis, Ball State University. Accessed January 17, 2021. http://cardinalscholar.bsu.edu/handle/123456789/199583.

MLA Handbook (7^th Edition):

Williamson, Lauren M. “Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo.” 2015. Web. 17 Jan 2021.

Vancouver:

Williamson LM. Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo. [Internet] [Masters thesis]. Ball State University; 2015. [cited 2021 Jan 17]. Available from: http://cardinalscholar.bsu.edu/handle/123456789/199583.

Council of Science Editors:

Williamson LM. Effects of subinhibitory carvacrol levels on Bacillus cereus virulence during endophthalmitis in vivo. [Masters Thesis]. Ball State University; 2015. Available from: http://cardinalscholar.bsu.edu/handle/123456789/199583

Georgia Tech

26. Hott, John Lester. Photochemical alterations of ocular lens proteins.

Degree: PhD, Chemistry, 1991, Georgia Tech

URL: http://hdl.handle.net/1853/30087

Subjects/Keywords: Eye Diseases; Crystalline lens

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hott, J. L. (1991). Photochemical alterations of ocular lens proteins. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30087

Chicago Manual of Style (16^th Edition):

Hott, John Lester. “Photochemical alterations of ocular lens proteins.” 1991. Doctoral Dissertation, Georgia Tech. Accessed January 17, 2021. http://hdl.handle.net/1853/30087.

MLA Handbook (7^th Edition):

Hott, John Lester. “Photochemical alterations of ocular lens proteins.” 1991. Web. 17 Jan 2021.

Vancouver:

Hott JL. Photochemical alterations of ocular lens proteins. [Internet] [Doctoral dissertation]. Georgia Tech; 1991. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1853/30087.

Council of Science Editors:

Hott JL. Photochemical alterations of ocular lens proteins. [Doctoral Dissertation]. Georgia Tech; 1991. Available from: http://hdl.handle.net/1853/30087

The Ohio State University

27. Todd, Levi, Todd. The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia.

Degree: PhD, Neuroscience Graduate Studies Program, 2017, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1510240057079338

► Eye diseases that result in blindness are often caused by the death of retinal neurons. Muller glia are the major glial support cells in the… (more)

▼ Eye diseases that result in blindness are often caused by the death of retinal neurons. Muller glia are the major glial support cells in the retina and possess the potential to reprogram into neurogenic progenitor cells. In the fish, Muller glia are able to regenerate a fully functional retina following severe retinal damage. In avian and mammalian retinas, Muller glia retain their regenerative potential but to an insufficient extent to restore lost vision. A better understanding of the mechanisms that govern the reprogramming of Muller glia into neurogenic Muller glia-derived progenitor cells (MGPCs) may allow us to harness these cells in a therapeutically useful context. This dissertation examines the cell signaling mechanisms that regulate Muller glia homeostasis, de-differentiation, proliferation, and neurogenesis. The first chapter focuses on how Hedgehog signaling stimulates Muller glia to reprogram into proliferating progenitors in the chick retina. We show that the Hedgehog-pathway components are up-regulated in damaged retinas when MGPCs are known to form. Furthermore, we find that the Shh-ligand is potentially released by retinal ganglion cells and received by proliferating Muller glia. We report that activation of the Hedgehog pathway increases Muller glia proliferation in damaged and FGF2-stimulated retinas. Consistent with these findings, inhibition of Hedgehog-signaling at the level of the ligand, receptor, and transcription factors attenuate MGPC formation. Activation of Hedgehog signaling in the absence of damage or FGF2-application has no effect on Muller glia. We propose a model wherein retinal damage or FGF2-stimulation renders Muller glia responsive to the mitogenic effects of Hedgehog-signaling. The second chapter examines how Jak/Stat signaling impacts the regenerative capacity of the avian retina. We find that Jak/Stat signaling is rapidly activated in Muller glia in response to retinal damage. We also show that inhibition of the Jak/Stat pathway at the level of the gp130-receptor, Jak2 kinase, and Stat3 transcription factor each diminish the ability of Muller glia to reprogram in to proliferating progenitors. Importantly, we find that inhibition of Jak/Stat signaling increases the neurogenic capacity of MGPCs after damage. This chapter implicates Jak/Stat signaling as a key component of MGPC-mediated retinal regeneration and an attractive target for boosting the neurogenic potential of Muller glia.The third chapter analyzes how Retinoic acid (RA)-signaling regulates the proliferative and neurogenic potential of avian Muller glia. We find that the RA-component CRABP is specifically up-regulated by Muller glia in response to retinal injury. We also show that RA-activation increases MGPC formation in damaged and FGF2-treated retinas. This chapter also provides novel data that RA-activation can increase neural differentiation from MGPC progeny. Taken together, these data implicate RA-signaling has an important pathway in the regulation of Muller glia-mediated retinal regeneration. Collectively,… Advisors/Committee Members: Fischer, Andrew (Advisor).

Subjects/Keywords: Neurosciences; Muller glia; Eye diseases; Proliferative and Neurogenic Capacity

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APA (6^th Edition):

Todd, Levi, T. (2017). The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1510240057079338

Chicago Manual of Style (16^th Edition):

Todd, Levi, Todd. “The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia.” 2017. Doctoral Dissertation, The Ohio State University. Accessed January 17, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1510240057079338.

MLA Handbook (7^th Edition):

Todd, Levi, Todd. “The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia.” 2017. Web. 17 Jan 2021.

Vancouver:

Todd, Levi T. The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia. [Internet] [Doctoral dissertation]. The Ohio State University; 2017. [cited 2021 Jan 17]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1510240057079338.

Council of Science Editors:

Todd, Levi T. The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia. [Doctoral Dissertation]. The Ohio State University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1510240057079338

Queensland University of Technology

28. Collins, Michael John. The interaction between accommodation and monochromatic aberrations of the human eye.

Degree: 1996, Queensland University of Technology

URL: http://eprints.qut.edu.au/36728/

Subjects/Keywords: Eye Refractive errors; Eye Diseases; Vision; thesis; doctoral

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Collins, M. J. (1996). The interaction between accommodation and monochromatic aberrations of the human eye. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/36728/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Collins, Michael John. “The interaction between accommodation and monochromatic aberrations of the human eye.” 1996. Thesis, Queensland University of Technology. Accessed January 17, 2021. http://eprints.qut.edu.au/36728/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Collins, Michael John. “The interaction between accommodation and monochromatic aberrations of the human eye.” 1996. Web. 17 Jan 2021.

Vancouver:

Collins MJ. The interaction between accommodation and monochromatic aberrations of the human eye. [Internet] [Thesis]. Queensland University of Technology; 1996. [cited 2021 Jan 17]. Available from: http://eprints.qut.edu.au/36728/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Collins MJ. The interaction between accommodation and monochromatic aberrations of the human eye. [Thesis]. Queensland University of Technology; 1996. Available from: http://eprints.qut.edu.au/36728/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

29. Sýkorová, Tereza. Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/180285

► This bachelor's thesis deals with the detection of the symptoms of diabetic retinopathy at retinal images taken by a digital fundus camera. Optic disc, fovea,… (more)

Subjects/Keywords: diabetická retinopatie; sítnice oka; onemocnění oka; zpracování obrazu; OpenCV; C++; diabetic retinopathy; eye retina; eye diseases; image processing; OpenCV; C++

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sýkorová, T. (2019). Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/180285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sýkorová, Tereza. “Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina.” 2019. Thesis, Brno University of Technology. Accessed January 17, 2021. http://hdl.handle.net/11012/180285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sýkorová, Tereza. “Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina.” 2019. Web. 17 Jan 2021.

Vancouver:

Sýkorová T. Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11012/180285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sýkorová T. Detekce projevů onemocnění diabetes na sítnici lidského oka: Detection of Diseases of Diabetes on the Human Eye Retina. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/180285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

30. Palacková, Bianca. Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/180286

► The goal of this thesis is to design and implement software for comparison of retinal images with pathological findings. The most common diseases affecting the… (more)

Subjects/Keywords: sietnica oka; choroby oka; diabetická retinopatia; spracovanie obrazu; OpenCV; C++; eye retina; eye diseases; diabetic retinopathy; image processing; OpenCV; C++

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Palacková, B. (2019). Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/180286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Palacková, Bianca. “Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings.” 2019. Thesis, Brno University of Technology. Accessed January 17, 2021. http://hdl.handle.net/11012/180286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Palacková, Bianca. “Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings.” 2019. Web. 17 Jan 2021.

Vancouver:

Palacková B. Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11012/180286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Palacková B. Porovnávání retinálních obrázků s patologickými nálezy: Comparison of Retinal Images with Pathological Findings. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/180286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations