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Univerzitet u Beogradu

1. Jadranin, Milka B., 1971-. Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L.

Degree: Hemijski fakultet, 2014, Univerzitet u Beogradu

Hemija - Organska hemija / Chemistry - Organic Chemistry

Rod Euphorbia, sa više od 2.000 vrsta jednogodišnjih, dvogodišnjih ili višegodišnjih cvetnica koje su članovi familije Euphorbiaceae, jedan je od najvećih i najraznovrsnijih rodova ne samo u svojoj familiji, već u celom biljnom carstvu. Biljke ovog roda koriste se u tradicionalnoj medicini još od antičkih vremena. Dosadašnja fitohemijska proučavanja pokazala su da vrste roda Euphorbia proizvode veoma raznovrsne sekundarne metabolite, uključujući različite terpene (seskviterpeni, diterpeni i triterpeni), steroide, cerebrozide, glicerole i fenolna jedinjenja (floracetofenoni, flavonoidi, tanini, kumarini). Mnoga od ovih jedinjenja pokazuju biološke aktivnosti, a najvažnije su reverzija višestruke rezistencije na lekove, antimitotsko, antiproliferativno, citotoksično, antivirusno, antimikrobno, antitumorsko, antiinflamatorno, tumor promotorsko i proinflamatorno dejstvo. Vrste iz roda Euphorbia su bogat izvor jatrofana, makrocikličnih diterpena osnovne trans-biciklo[10.3.0]pentadekanske strukture, za koje je karakteristično postojanje veoma fleksibilnog dvanaestočlanog prstena. To su veoma funkcionalizovana, različito oksigenovana jedinjenja; u biljkama se obično nalaze u obliku polihidroksilovanih diterpena esterifikovanih različitim kiselinama (acetil, propanoil, nbutanoil, izobutanoil, izovaleril, angeloil, tigloil, benzoil, nikotinoil derivati, itd.), zbog čega su poznati i pod nazivom jatrofanski poliestri. U okviru ove disertacije ispitivani su jatrofanski diterpeni iz vrste Euphorbia dendroides L. poreklom iz Crne Gore koja do sada nije fitohemijski proučavana. Proučavanje je obuhvatalo dve celine: nadzemni deo i mlečni lateks. Iz nadzemnog dela E. dendroides izolovano je i okarakterisano šest novih jatrofana, koji su nazvani eufodendrofani A – F (1 – 5, 16), a iz mlečnog lateksa E. dendroides izolovano je i okarakterisano trinaest novih jatrofana, eufodendrofani G – S (6 – 15, 17 – 19), kao i tri jatrofana izolovana iz nadzemnih delova (1, 2, 16). Izolovani jatrofani imaju vrlo slične strukture. Jatrofani 1 – 15 se međusobno razlikuju samo po vrsti, broju i položaju supstituenata, dok se jatrofani 16 – 19 od njih razlikuju po tome što sadrže endocikličnu (Δ5) umesto egzociklične (Δ6(17)) dvostruke veze. Jedinjenja 1 – 14 su penta- ili heksaesterifikovani jatrofanski polioli koji sadrže keto grupu u položaju C-14, jednu endocikličnu 11 E– i jednu egzocikličnu C-6(17) dvostruku vezu...

Advisors/Committee Members: Tešević, Vele, 1963-.

Subjects/Keywords: Euphorbia dendroides; Euphorbiaceae; Isolation; Characterization; Jatrophanes; Euphodendrophanes AS; P-glycoprotein (P-gp); Multidrug resistance; (MDR); Tubulin.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jadranin, Milka B., 1. (2014). Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jadranin, Milka B., 1971-. “Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L.” 2014. Thesis, Univerzitet u Beogradu. Accessed November 17, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jadranin, Milka B., 1971-. “Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L.” 2014. Web. 17 Nov 2019.

Vancouver:

Jadranin, Milka B. 1. Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L. [Internet] [Thesis]. Univerzitet u Beogradu; 2014. [cited 2019 Nov 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jadranin, Milka B. 1. Izolovanje, karakterizacija i biološka aktivnost jatrofanskih diterpena iz Euphorbia dendroides L. [Thesis]. Univerzitet u Beogradu; 2014. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Jadranin Milka. Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L.

Degree: PhD, Chemistry, 2013, University of Belgrade

Genus Euphorbia, with more than 2,000 species of annual, biennial or perennial flowering plants belonging to the family Euphorbiaceae, is one of the largest and most diverse genera not only in the spurge family but in the entire plant kingdom. Plants of this genus are used in traditional medicine since ancient times. Phytochemical studies up to now have shown that the species of the genus Euphorbia produce a variety of secondary metabolites, including various terpenes (sesquiterpenes, diterpenes and triterpenes), steroids, cerebrosides, glycerols and phenolic compounds (phloracetophenones, flavonoids, tannins, coumarins). These compounds perform many different activities, including modulability of multidrug resistance, microtubuleinteracting activity, antiproliferative, cytotoxic, antiviral, antimicrobial, anticancer, antiinflammatory, tumor promoting and proinflammatory effects. Genus Euphorbia is a rich source of jatrophanes, macrocyclic diterpenes with basic trans-bicyclo[10.3.0]pentadecane structure, which are characterized by the existence of a flexible twelve membered ring. These are very functionalized compounds with various oxygenation stages; in plants are usually found in the form of polyhydroxylated diterpenes esterified with various acids (acetyl, propanoil, n-butanoyl, isobutanoyl, isovaleryl, angeloyl, tigloyl, benzoyl, nicotinoyl derivatives, etc...), and are sometimes called jatrophane polyesters. In this dissertation, jatrophane diterpenes from Euphorbia dendroides L. originating from Montenegro were investigated. The study comprises investigation of the aerial parts and of the milky latex. From the aerial parts of E. dendroides six new jatrophanes, namely euphodendrophanes A - F (1 - 5, and 16), were isolated and characterized. From the milky latex of E. dendroides, in addition to 1, 2, and 16, the constituents of the aerial parts, thirteen new jatrophanes, euphodendrophanes G - S (6 - 15, and 17 - 19), were isolated and characterized. All isolated jatrophanes have very similar structures. Jatrophanes 1 15 are differing only in the type, number and position of substituents, while jatrophanes 16 19 differ from them in that they contain endocyclic (Δ5) instead of exocyclic (Δ6(17)) double bond. Compounds 1 14 are penta- or hexaesterified jatrophane-type polyols containing a keto carbonyl group at C-14, an endocyclic 11 Eand an exocyclic C- 6(17) double bond. Compound 15 is triesterified jatrophane-type polyol containing two keto carbonyl groups (at C-9 and C-14), an endocyclic 11 Eand an exocyclic C-6(17) double bond. Compounds 16 19 are heptaesterified jatrophane-type polyols containing a ketone carbonyl group at C-14 and two endocyclic double bonds (Δ5 and Δ11). The biological activities of the representative set of isolated jatrophanes have been assessed. Compounds 1 – 7, 9, 10, and 16 – 19 were evaluated for their capacity to inhibit in vitro growth of six human cancer cell lines: non-small cell lung carcinoma (NCIH460 and NCI-H460/R), colorectal carcinoma (DLD-1 and DLD-TxR), and…

Subjects/Keywords: Euphorbia dendroides; Euphorbiaceae; Isolation; Characterization; Jatrophanes; Euphodendrophanes AS; P-glycoprotein (P-gp); Multidrug resistance; (MDR); Tubulin.; Euphorbia dendroides; Euphorbiaceae; Izolovanje; Karakterizacija; Jatrofani; Eufodendrofani AS; P-glikoprotein (P-gp); Višestruka reverzija na lekove (MDR); Tubulin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Milka, J. (2013). Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L. (Doctoral Dissertation). University of Belgrade. Retrieved from http://dx.doi.org/10.2298/BG20131213JADRANIN ; http://eteze.bg.ac.rs/application/showtheses?thesesId=921 ; https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44744975

Chicago Manual of Style (16th Edition):

Milka, Jadranin. “Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L.” 2013. Doctoral Dissertation, University of Belgrade. Accessed November 17, 2019. http://dx.doi.org/10.2298/BG20131213JADRANIN ; http://eteze.bg.ac.rs/application/showtheses?thesesId=921 ; https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44744975.

MLA Handbook (7th Edition):

Milka, Jadranin. “Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L.” 2013. Web. 17 Nov 2019.

Vancouver:

Milka J. Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L. [Internet] [Doctoral dissertation]. University of Belgrade; 2013. [cited 2019 Nov 17]. Available from: http://dx.doi.org/10.2298/BG20131213JADRANIN ; http://eteze.bg.ac.rs/application/showtheses?thesesId=921 ; https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44744975.

Council of Science Editors:

Milka J. Isolation, characterization and biological activity of jatrophane diterpens from Euphorbia dendroides L. [Doctoral Dissertation]. University of Belgrade; 2013. Available from: http://dx.doi.org/10.2298/BG20131213JADRANIN ; http://eteze.bg.ac.rs/application/showtheses?thesesId=921 ; https://fedorabg.bg.ac.rs/fedora/get/o:7449/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44744975

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