subject:(Etomidato)

1. Gutiérrez Fernández, Margarita. Propofol y etomidato en legrado uterino instrumental .

Degree: 2001, Universidad Veracruzana

URL: http://cdigital.uv.mx/handle/123456789/32132

Subjects/Keywords: Aborto; Anestésicos; Etomidato; Propofol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gutiérrez Fernández, M. (2001). Propofol y etomidato en legrado uterino instrumental . (Masters Thesis). Universidad Veracruzana. Retrieved from http://cdigital.uv.mx/handle/123456789/32132

Chicago Manual of Style (16^th Edition):

Gutiérrez Fernández, Margarita. “Propofol y etomidato en legrado uterino instrumental .” 2001. Masters Thesis, Universidad Veracruzana. Accessed March 03, 2021. http://cdigital.uv.mx/handle/123456789/32132.

MLA Handbook (7^th Edition):

Gutiérrez Fernández, Margarita. “Propofol y etomidato en legrado uterino instrumental .” 2001. Web. 03 Mar 2021.

Vancouver:

Gutiérrez Fernández M. Propofol y etomidato en legrado uterino instrumental . [Internet] [Masters thesis]. Universidad Veracruzana; 2001. [cited 2021 Mar 03]. Available from: http://cdigital.uv.mx/handle/123456789/32132.

Council of Science Editors:

Gutiérrez Fernández M. Propofol y etomidato en legrado uterino instrumental . [Masters Thesis]. Universidad Veracruzana; 2001. Available from: http://cdigital.uv.mx/handle/123456789/32132

Universidade Federal de Viçosa

2. Lukiya Silva Campos Favarato. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.

Degree: 2009, Universidade Federal de Viçosa

URL: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

► The imidazole derivative etomidate is classified as a non-barbituric general anesthetic with hypnotic action for intravenous usage. Remifentanil is a selective μ- receptor agonist opioid… (more)

▼ The imidazole derivative etomidate is classified as a non-barbituric general anesthetic with hypnotic action for intravenous usage. Remifentanil is a selective μ- receptor agonist opioid of ultra-short action and high analgesic potency with an unique pharmacokinetic due to a lateral metil-ester branch that allows a fast metabolism by non-specific esterases (carboxylesterases) present in blood and tissues. Twenty female mongrel cats were used, all healthy, with a mean weight of 3.50.49 kg, admitted for an elective overiohysterectomy. Pre-anesthetic medication was made with acepromazine, 0.1mg.Kg-1 intravenously, and etomidate was used for anesthetic induction, also intravenously, on a dose of 3 mg.kg-1. Continuous act, animals were randomly divided in 2 groups of 10 animals each, maintaining anesthesia for 45 minutes using the protocols: for group 1 (IE), continuous infusion of etomidate at a rate of 0.4 mg.kg- 1.min-1; for group 2 (IER), continuous infusion of etomidate and remifentanil at rates of 0.3 mg.kg-1.min-1 and 0.4 μg.kg-1.min-1, respectively. The following parameters where analyzed: heart rate; oxyhemoglobin saturation; systolic arterial pressure; respiratory rate; body temperature; arterial blood gas; sodium, potassium, ionized calcium, chloride and glucose dosages; autonomic responses to nociceptive stimulus; electrocardiogram; palpebral, corneal, laryngeal and tracheal reflexes; time needed for recovery from the anesthesia; adverse effects record; final solution osmolarity; total number of erythrocytes; hematocrit; hemoglobin measure; total, direct and indirect bilirrubin; plasma free hemoglobin; haptoglobin and; erythrocyte fragility. Scheduled times for measurements were T0 (before), before pre-anesthetic administration (MPA); T1 (MPA), 20 minutes after MPA; T2 (5 min), 5 minutes after anesthetic induction and orotracheal intubation; T3 (15 min), T4 (30min), T5 (45min) and T6 (3h 45min) at 15, 30, 45 and 3 hours and 45 minutes after T2, respectively. Continuous infusion of etomidate and its association with remifentanil in cats promoted heart rate and blood pressure stability, hypoventilation and respiratory acidosis. Etomidate in continuous infusion could not suppress autonomic responses to nociceptive stimulus and so, inadequate for surgery procedures. Etomidate associated to remifentanil efficiently controlled autonomic responses to nociceptive stimulus before and after surgery. Both the infusions tested promoted transitory hyperglycemia during anesthesia and after it. Etomidate associated or not with remifentanil by continuous infusion promoted a longer recovery with intense side effects such as myoclonus and emesis. Etomidate and etomidate associated with remifentanil infusions, associated with acepromazine promoted important decrease in erythrocytes number, hematocrit and hemoglobin. Both the infusions tested promoted increases in free hemoglobin and bilirrubin and decrease of haptaglobin as a result of intravascular hemolysis. Etomidate alone and its association with remifentanil in… Advisors/Committee Members: Luiz Gonzaga Pompermayer, José Dantas Ribeiro Filho, Ricardo Junqueira Del Carlo, Aloísio da Silva Pinto, Humberto Pereira Oliveira, Fernanda Antunes.

Subjects/Keywords: Infusão contínua; Etomidato; Hemólise; Rumifentanil; ANESTESIOLOGIA ANIMAL; Continuous infusion; Etomidate; Hemolysis; Remifentanil

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Favarato, L. S. C. (2009). Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. (Thesis). Universidade Federal de Viçosa. Retrieved from http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Favarato, Lukiya Silva Campos. “Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.” 2009. Thesis, Universidade Federal de Viçosa. Accessed March 03, 2021. http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Favarato, Lukiya Silva Campos. “Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.” 2009. Web. 03 Mar 2021.

Vancouver:

Favarato LSC. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. [Internet] [Thesis]. Universidade Federal de Viçosa; 2009. [cited 2021 Mar 03]. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Favarato LSC. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. [Thesis]. Universidade Federal de Viçosa; 2009. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Technical University of Lisbon

3. Félix, Nuno Manuel Mira Flor Santos. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).

Degree: 2017, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691

►

Tese de Doutoramento em Ciências Veterinárias na Especialidade de Clínica

O Choque Hemorrágico (CH) pode complicar-se por “insuficiência adrenal relativa” (IAR). Neste estudo avaliou-se a… (more)

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Tese de Doutoramento em Ciências Veterinárias na Especialidade de Clínica

O Choque Hemorrágico (CH) pode complicar-se por “insuficiência adrenal relativa” (IAR). Neste estudo avaliou-se a contribuição do etomidato e apoptose da adrenal na IAR pós-CH. Ratos machos Wistar foram divididos em 4 grupos: G0 (anestesia geral com isoflurano e ventilação mecânica, 16 ratos), G1 (como G0 mas com buprenorfina, 16 ratos), G2 (como G1 mas com CH, 16 ratos) e G3 (como G2 mas com etomidato antes do CH, 16 ratos). CH induzido por recolha de sangue (30% volume sanguíneo). Resuscitação aos 90 minutos pós-CH, consistindo no sangue recolhido associado a soro fisiológico. Aos 0, 90, 150 and 240 minutos após início do CH, mediram-se gasimetria e níveis plasmáticos de hormona adrenocorticotrópica, corticosterona, TNF-α, IL6, IL10 e por RT-PCR, TNF-α, IL6 e IL10. Apoptose avaliada por TUNEL e caspase-3 (immunofluorescência); necrose por escala específica. G1 apresentou taxa de apoptose mais elevada que G0. G2 e G3 tiveram níveis mais elevados de apoptose e necrose que outros grupos. Comparado com G2, G3 apresentou níveis de corticosterona compativeis com IAR e níveis mais baixos de PO2, PO2/FiO2, BE, bicarbonato, apoptose e necrose, e mais altos das citoquinas e TNF- α.IAR foi associada a etomidato mas não a apoptose neste modelo.

ABSTRACT - Critical Illness-Related Corticosteroid Insufficiency in Hemorrhagic Shock- an experimental study about its pathophysiologic mechanisms in a rat model (Rattus norvegicus) - Hemorrhagic Shock (HS) can be complicated by critical illness-related corticosteroid insufficiency (CIRCI). This study evaluated if etomidate and adrenal gland apoptosis contributed to HS-associated CIRCI. Male Wistar rats were divided in 4 groups: G0 (general anesthesia with isoflurane and mechanical ventilation, 16 rats), G1 (similar to G0, but with buprenorphine, 16 rats), G2 (similar to G1 but with HS, 16 rats) and G3 (similar to G2 but with etomidate before HS, 16 rats). HS was induced by collecting 30% of the blood volume and resuscitation (90 minutes later) consisted in the collected blood and normal saline. Blood gas analysis, adrenocorticotropic hormone, corticosterone, TNF-α, IL6, IL10 and TNF-α, IL6 and IL10 mRNA quantified by RT-PCR were determined at 0, 90, 150 and 240 minutes post-HS induction. Apoptosis and necrosis were determined by TUNEL and active caspase-3 immunofluorescence and a standardized necrosis score, respectively. G1 had higher adrenal apoptosis than G0. G2 and G3 had significantly higher levels of apoptosis and necrosis. G3 had significantly lower levels of corticosterone (compatible with CIRCI), PO2, PO2/FiO2, BE, bicarbonate, apoptosis and necrosis score and higher levels of cytokines and TNF-α than G2. Etomidate but not apoptosis was associated to CIRCI in this HS model.

N/A

Advisors/Committee Members: Niza, Maria Manuela Rodeia Espada.

Subjects/Keywords: Choque; Rato; Adrenal; Insuficiência; Etomidato; Apoptose; Citoquina; Buprenorfina; Hemorrhagic; shock; rat; adrenal; insufficiency; etomidate; apoptosis; mRNA; cytokine; buprenoprhine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Félix, N. M. M. F. S. (2017). Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Félix, Nuno Manuel Mira Flor Santos. “Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).” 2017. Thesis, Technical University of Lisbon. Accessed March 03, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Félix, Nuno Manuel Mira Flor Santos. “Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus).” 2017. Web. 03 Mar 2021.

Vancouver:

Félix NMMFS. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Mar 03]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Félix NMMFS. Insuficiência adrenal relativa em choque hemorrágico : estudo experimental acerca dos seus mecanismos fisiopatológicos em rato (Rattus norvegicus). [Thesis]. Technical University of Lisbon; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13691

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Autònoma de Barcelona

4. Fresno Bermejo, Laura. Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos.

Degree: Departament de Medicina i Cirurgia Animals, 2007, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/5735

► Etomidate (ETO), a short-acting intravenous (IV) hypnotic agent, has been used for both, anaesthetic induction and anaesthetic maintenance, in either human or veterinary anaesthesia. Its… (more)

▼ Etomidate (ETO), a short-acting intravenous (IV) hypnotic agent, has been used for both, anaesthetic induction and anaesthetic maintenance, in either human or veterinary anaesthesia. Its cardiovascular stability and minimal respiratory depression compared to other induction agents makes it a useful and safe agent for general anesthesia. ETO is also characterised by its favourable effects related to pharmacokinetics. It has a rapid onset of action and fast recovery of consciousness, and has very little cumulation. Although ETO has been used satisfactorily in obstetric anaesthesia, little is known about its placental transfer and its effects in the foetus and the pregnant ewe. For this purpose, two studies were designed. In the first study, placental transfer of ETO was determined; while in the second one, effects of ETO administration were evaluated in the pregnant sheep and her foetus. In the first study, 12 pregnant Lacaune and Ripollese breed sheep weighing (mean ± SD) 62 ± 9 kg were included. Mean gestational age was 122 days (range 110 to 134 days; term 147-150 days). Sheep and foetuses were chronically catheterized. The placental transfer in the pregnant ewe was evaluated following the administration of an IV bolus of ETO 1 mg/kg in 6 sheep; and after a 1 h-infusion of 100 µg/kg min-1 of ETO preceded by an IV bolus of 1 mg/kg in another 6 animals. In ewes, ETO concentration and AUC (area under the plasma concentration-time curve) were higher than those found in foetuses. After ETO bolus dose, the foetus:ewe AUC ratio was 0.45±0.32, and mean residence time (MRT) was 20±7 min for mothers and 22±3 min for foetuses. After ETO infusion, the AUC ratio was 0.37±0.08, and MRT was 46±12 min for ewes and 46±22 min for foetuses. Although ETO crosses the placenta very rapidly and reaches the foetus in high amounts, a certain placental barrier effect limits its transfer. There is no evidence of cumulative effects of the drug in the foetus, being foetal ETO elimination as rapid as in the mother. In the second study, 14 pregnant Lacaune and Ripollese breed sheep weighing (mean ± SD) 63 ± 8.5 kg were included in the study. Mean gestational age was 123 days (range 110 to 134 days). Sheep and foetuses were chronically catheterized. Cardiovascular and acid-base effects of ETO administration in the pregnant ewe and her fetus were determined following the administration of an IV bolus of ETO 1 mg/kg in 7 sheep; and after a 1 h-infusion of 100 µg/kg min-1 of ETO preceded by an IV bolus of 1 mg/kg in another 7 animals. ETO administration did not depress cardiovascular function in the pregnant ewe and fetus. Only when administered as a continuous infusion did maternal heart rate and blood pressure increase during the second half of infusion and initial stages of recover. In both experiments, main acid-base alterations showed a transient and slight respiratory depression in both mother and fetus, characterised by a slight decrease in arterial pH and a slight increase in arterial PaCO2. These respiratory… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), García Arnás, Félix (director).

Subjects/Keywords: Gestación; Etomidato; Oveja; Ciències de la Salut; 616

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fresno Bermejo, L. (2007). Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/5735

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fresno Bermejo, Laura. “Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos.” 2007. Thesis, Universitat Autònoma de Barcelona. Accessed March 03, 2021. http://hdl.handle.net/10803/5735.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fresno Bermejo, Laura. “Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos.” 2007. Web. 03 Mar 2021.

Vancouver:

Fresno Bermejo L. Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2007. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10803/5735.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fresno Bermejo L. Administración de Etomidato-Lipuro en ovejas gestantes a término. Estudio del paso placentario y efectos cardiovasculares, respiratorios y del equilibrio ácido-base, en las madres y sus fetos. [Thesis]. Universitat Autònoma de Barcelona; 2007. Available from: http://hdl.handle.net/10803/5735

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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