Open Access Theses and Dissertations

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You searched for subject:(Etomidate). Showing records 1 – 2 of 2 total matches.

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1. Smith, Briony. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis).

Degree: MS, Biomedical Sciences, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/174300 

Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research. In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses of etomidate (15, 22.5, and 30 mg/L) and in 3 doses of benzocaine (0.1%, 0.5%, and 1%) compared with the ‘gold standard,’ tricaine methanesulfonate (MS222; 2 g/L). We then chose an optimal dose for each alternative anesthetic according to induction time, duration of surgical plane, and time to complete recovery. The optimal etomidate and benzocaine doses (22.5 mg/L and 0.1%, respectively) as well as the MS222 dose were then used to achieve a surgical plane of anesthesia, with the addition of flunixin meglumine (25 or 50 mg/kg) administered in the dorsal lymph sac at the completion of mock oocyte harvest. Efficacy of the analgesic was assessed at 1, 3, 6, and 24 h postoperatively by using acetic acid testing (AAT). Histology of the liver, kidney, and tissues surrounding the dorsal lymph sac was performed at day 3, 14, and 28 in each group of animals. Mild to moderate myocyte degeneration and necrosis were present in tissues surrounding the dorsal lymph sac at both flunixin meglumine doses after etomidate and benzocaine anesthesia. In addition, the 50-mg/kg dose of flunixin meglumine resulted in the death of 5 of the 12 frogs within 24 h, despite an otherwise uneventful anesthetic recovery. In conclusion, benzocaine and etomidate offer alternative anesthetic regimens, according to typical requirements for an anesthetic event. Flunixin meglumine at the 25-mg/ kg dose provided analgesic relief at the latest time point during etomidate dosage and at all time points during benzocaine dosage, but further characterization is warranted regarding long-term or repeated analgesic administration. Advisors/Committee Members: Vemulapalli, Tracy (advisor), Baetge, Courtney (advisor), Elliott, James (committee member), Gresham, Vincent (committee member).

Subjects/Keywords: Xenopus; MS222; Flunixin Meglumine; Etomidate; Benzocaine

…OF ETOMIDATE, BENZOCAINE, AND MS222 ANESTHESIA WITH AND WITHOUT SUBSEQUENT FLUNIXIN… …personnel handling the *Reprinted with permission from “Comparison of Etomidate, Benzocaine, and… …11,40 Other anesthetic options to explore in Xenopus include drugs such as etomidate… …benzocaine in solution, and alfaxalone. Etomidate, an imidazole-derivative anesthetic and hypnotic… …effects.7 In the current study, we had 2 goals. The first was to determine whether etomidate or… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Smith, B. (2018). Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis). (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174300

Chicago Manual of Style (16th Edition):

Smith, Briony. “Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis).” 2018. Masters Thesis, Texas A&M University. Accessed March 06, 2021. http://hdl.handle.net/1969.1/174300.

MLA Handbook (7th Edition):

Smith, Briony. “Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis).” 2018. Web. 06 Mar 2021.

Vancouver:

Smith B. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis). [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1969.1/174300.

Council of Science Editors:

Smith B. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus Laevis). [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/174300

2. Boidin, Marinus Pieter. Anaesthesia and its interactions with the components of critical care medicine.

Degree: 1985, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/38759 

textabstractThe aim of this thesis is to show how anaesthesia and CCM are essentially interactive and how the quality and standard of care in these two specialities are interdependent. As a direct result of this thesis some of the old and well-established principles in anaesthesia and CCM were revised and new options in therapy were created. The investigations, and eventual results, could only be realised because the author has had the opportunity to work in both specialities at the same time

Subjects/Keywords: airway patency; anesthesi; epiglotis; etomidate; intensive care; vitamin C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Boidin, M. P. (1985). Anaesthesia and its interactions with the components of critical care medicine. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/38759

Chicago Manual of Style (16th Edition):

Boidin, Marinus Pieter. “Anaesthesia and its interactions with the components of critical care medicine.” 1985. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 06, 2021. http://hdl.handle.net/1765/38759.

MLA Handbook (7th Edition):

Boidin, Marinus Pieter. “Anaesthesia and its interactions with the components of critical care medicine.” 1985. Web. 06 Mar 2021.

Vancouver:

Boidin MP. Anaesthesia and its interactions with the components of critical care medicine. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1985. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1765/38759.

Council of Science Editors:

Boidin MP. Anaesthesia and its interactions with the components of critical care medicine. [Doctoral Dissertation]. Erasmus University Medical Center; 1985. Available from: http://hdl.handle.net/1765/38759

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