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Universitat Autònoma de Barcelona

1. Macarulla Mercadé, Teresa. Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas.

Degree: Departament de Medicina, 2015, Universitat Autònoma de Barcelona

Pancreatic cancer presented a dismal prognosis. During the last years an efford has been done in order to improve the results of the chemotherapy in this tumor, however, the overall survival in these patients is less than twelve months. A recent publication suggested that in the next decade pancreatic cancer will be the second leading cause of cancer related dead. The reason is that we don´t have a protocol for diagnosed the tumor in an early stage, when it is potencially curable, and also the lack of effective treatments. The improvement in the knowledge of the biology of the pancreatic neoplasm had allowed to define this tumor as heterogeneous disease, and also define the most common mutations in the pancreatic tumor. Unfortunatelly these mutations are not therapeutic targets. In the last years we identify a mutations, with low frequency, that are target therapies. This tesis is an efford durting four years to collect clincal and biological information of the patients who have participated in the molecular pre-screening of the Vall d´Hebrón University hospital in Barcelona. The objective of this work is to deep in understanding the biology of pancreatic cancer, and also identify potential target therapies. With it we can increase the weapons to treat pancreatic cancer. The most freqüent mutation in pancreatic cancer is KRAS, for this reason, in this tesis we focused on deeping the understanding of this alteration. During years we have improved the sensitivity of the techniques that allow the diagnosis of these molecular alterations, thus allowing a better understanding of pancreatic cancer biology. We also investigate the benefit of the participation of the patients with an advanced pancreatic cancer that progressed to standard therapy to participated in a phase I trial in the Unidad de Fases I de l´Hospital Universitari Vall d´Hebrón. This work is a principle to continue working in the same direction Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Tabernero Caturla, Josep (director), true (authorsendemail).

Subjects/Keywords: Càncer de pancrees; Cáncer de páncreas; Pancreatic cancer; Mutació de KRAS; Mutación de KRAS; KRAS mutation; Estudi fase I; Estudio fase I; Phase I clinical trial; Ciències de la Salut; 61

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APA (6th Edition):

Macarulla Mercadé, T. (2015). Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/377464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Macarulla Mercadé, Teresa. “Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas.” 2015. Thesis, Universitat Autònoma de Barcelona. Accessed December 08, 2019. http://hdl.handle.net/10803/377464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Macarulla Mercadé, Teresa. “Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas.” 2015. Web. 08 Dec 2019.

Vancouver:

Macarulla Mercadé T. Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2015. [cited 2019 Dec 08]. Available from: http://hdl.handle.net/10803/377464.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Macarulla Mercadé T. Análisis molecular en tumores de páncreas avanzados para identificar biomarcadores predictivos de respuesta a nuevas drogas biológicas. [Thesis]. Universitat Autònoma de Barcelona; 2015. Available from: http://hdl.handle.net/10803/377464

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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