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You searched for subject:(Epileptic activity). Showing records 1 – 3 of 3 total matches.

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Indian Institute of Science

1. Srinivas, V Kalyana. Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies.

Degree: 2008, Indian Institute of Science

Epilepsy is characterized by the hyperexcitability of individual neurons and hyper synchronization of groups of neurons (networks). The acquired changes that take place at molecular, cellular and network levels are important for the induction and maintenance of epileptic activity in the brain. Epileptic activity is known to alter the intrinsic properties and signaling of neurons. Understanding acquired changes that cause epilepsy may lead to innovative strategies to prevent or cure this neurological disorder. Advances in in vitro electrophysiological techniques together with experimental models of epilepsy are indispensible tools to understand molecular, cellular and network mechanisms that underlie epileptiform activity. The aim of the study was to investigate the epileptiform activity induced alterations in Ca2+ dynamics in apical dendrites of hippocampal subicular pyramidal neurons in slices and changes in network properties of cultured hippocampal neurons. We have also made attempts to develop an in vitro model of epilepsy using organotypic hippocampal slice cultures. In the first part of the present study, investigations on the basic properties of dendritic Ca2+ signaling in subicular pyramidal neurons during epileptiform activity are described. Subiculum, a part of the hippocampal formation is present, adjacent to the CA1 subfield. It acts as a transition zone between the hippocampus and entorhinal cortex. It receives inputs directly from the CA1 region, the entorhinal cortex, subcortical and other cortical areas. Several forms of evidences support the role of subiculum in temporal lobe epilepsy. Pronounced neuronal loss has been reported in various regions of the hippocampal formation (CA1 and CA3) leaving the subiculum generally intact in human epileptic tissue. It has been observed that epileptic activity is generated in subiculum in cases where the CA3 and CA1 regions are damaged or even absent. However, it is not clear how subicular neurons protect themselves from epileptic activity induced neuronal death. It is widely accepted that epileptiform activity induced neuronal damage is a result of an abnormally large influx of Ca2+ into neuronal compartments. In the present study, combined hippocampus / entorhinal cortical brain slices were exposed to zero Mg2+ + 4-amino pyridine artificial cerebrospinal fluid (ACSF) to generate spontaneous epileptiform discharges. Whole cell current-clamp recordings combined with Ca2+ imaging experiments (by incorporating Oregon green BAPTA-1 in the recording pipette) were performed on subicular pyramidal neurons to understand the changes in [Ca2+]i transients elicited in apical dendrites, in response to spontaneous epileptic discharges. To understand the changes occurring with respect to control, experiments were performed (in both control and in vitro epileptic conditions) where [Ca2+]i transients in dendrites were elicited by back propagating action potentials following somatic current injections. The results show clear distance-dependent changes in decay kinetics of… Advisors/Committee Members: Sikdar, Sujit K.

Subjects/Keywords: Calcium - Biophysics; Neurons - Physiology; Epilepsy; Hippocampus; Brain Slices; Hippocampal Neurons; Epileptic Seizure; Epileptogenesis; Epileptiform Activity; Hippocampal Neuronal Network; Apical Dendrites; Pyramidal Neurons; Neurophysiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Srinivas, V. K. (2008). Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Srinivas, V Kalyana. “Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies.” 2008. Thesis, Indian Institute of Science. Accessed September 22, 2017. http://hdl.handle.net/2005/756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Srinivas, V Kalyana. “Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies.” 2008. Web. 22 Sep 2017.

Vancouver:

Srinivas VK. Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies. [Internet] [Thesis]. Indian Institute of Science; 2008. [cited 2017 Sep 22]. Available from: http://hdl.handle.net/2005/756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Srinivas VK. Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies. [Thesis]. Indian Institute of Science; 2008. Available from: http://hdl.handle.net/2005/756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Kyoto University / 京都大学

2. Imamura, Hisaji. Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化.

Degree: 博士(医学), 2017, Kyoto University / 京都大学

新制・論文博士

乙第13120号

論医博第2133号

Subjects/Keywords: FDG-PET; Diffusion tractography; Mesial temporal lobe epilepsy; Epileptic activity; Seizure propagation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Imamura, H. (2017). Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/226747 ; http://dx.doi.org/10.14989/doctor.r13120

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Imamura, Hisaji. “Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化.” 2017. Thesis, Kyoto University / 京都大学. Accessed September 22, 2017. http://hdl.handle.net/2433/226747 ; http://dx.doi.org/10.14989/doctor.r13120.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Imamura, Hisaji. “Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化.” 2017. Web. 22 Sep 2017.

Vancouver:

Imamura H. Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化. [Internet] [Thesis]. Kyoto University / 京都大学; 2017. [cited 2017 Sep 22]. Available from: http://hdl.handle.net/2433/226747 ; http://dx.doi.org/10.14989/doctor.r13120.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Imamura H. Network specific change in white matter integrity in mesial temporal lobe epilepsy : 内側側頭葉てんかんにおけるネットワーク特異的な白質統合性の変化. [Thesis]. Kyoto University / 京都大学; 2017. Available from: http://hdl.handle.net/2433/226747 ; http://dx.doi.org/10.14989/doctor.r13120

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Kyoto University

3. Imamura, Hisaji. Network specific change in white matter integrity in mesial temporal lobe epilepsy .

Degree: 2017, Kyoto University

Subjects/Keywords: FDG-PET; Diffusion tractography; Mesial temporal lobe epilepsy; Epileptic activity; Seizure propagation

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Imamura, H. (2017). Network specific change in white matter integrity in mesial temporal lobe epilepsy . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/226747

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Imamura, Hisaji. “Network specific change in white matter integrity in mesial temporal lobe epilepsy .” 2017. Thesis, Kyoto University. Accessed September 22, 2017. http://hdl.handle.net/2433/226747.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Imamura, Hisaji. “Network specific change in white matter integrity in mesial temporal lobe epilepsy .” 2017. Web. 22 Sep 2017.

Vancouver:

Imamura H. Network specific change in white matter integrity in mesial temporal lobe epilepsy . [Internet] [Thesis]. Kyoto University; 2017. [cited 2017 Sep 22]. Available from: http://hdl.handle.net/2433/226747.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Imamura H. Network specific change in white matter integrity in mesial temporal lobe epilepsy . [Thesis]. Kyoto University; 2017. Available from: http://hdl.handle.net/2433/226747

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.