subject:(Epidural anesthesia)

1. Gering, Ana Paula [UNESP]. Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia.

Degree: 2012, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/88968

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A anestesia epidural, quando comparada à anestesia geral, apresenta algumas vantagens como redução dos custos, minimização dos riscos anestésicos por ocasionar poucas alterações respiratórias e cardiovasculares. Mas tem sido utilizada basicamente para cirurgias no membro posterior e inguinais já que o anestésico local quando administrado no espaço compreendido entre a sétima vértebra lombar e a primeira vértebra sacral proporciona bloqueio máximo até a quarta vértebra lombar. Uma alternativa para bloqueios mais craniais é a utilização do cateter epidural. Tal estudo avaliou, comparativamente os efeitos de duas doses de lidocaína (4 e 6 mg/Kg) administradas por via epidural na altura da primeira vértebra lombar em cadelas submetidas à ovariohisterectomia. Foram utilizadas 16 cadelas SRD, pesando entre 4 e 20 Kg e entre 1 e 6 anos. Todas receberam butorfanol e etomidato, ambos por via intravenosa nas doses de 0,4 mg/Kg e 2 mg/Kg respectivamente. Foram avaliados parâmetros cardiovasculares, hemogasométricos, ventilometricos e relacionados à analgesia. Os parâmetros fisiológicos avaliados não apresentaram diferença entre os grupos em com o uso de diferentes doses de lidocaína. Relativamente à analgesia, 25% dos animais do G4 apresentaram escore de dor considerado insuficiente. Contudo conclui-se que as duas doses de lidocaína, depositadas na altura da primeira vértebra lombar, não interferem nos parâmetros ventilométricos, hemogasométricos e cardiovasculares. E a dose de 6 mg/Kg determina melhor analgesia que a de 4 mg/Kg

Epidural anesthesia compared to general anesthesia has some advantages such as reducing cost, minimizing the risks of anesthesia by causing fewer respiratory and cardiovascular changes. But it has been used primarily for surgery in the posterior limb and inguinal as the local anesthetic when administered in the space between the seventh lumbar and first sacral vertebra provides maximum block until the fourth lumbar vertebra. An alternative to more bloks cranial is the use of epidural catheter. This study evaluated the comparative effects of two doses of lidocaine (4 and 6 mg/Kg) administered epidurally at the time of the first lumbar vertebra en bitches submitted to ovariohisterectomy. !6 mongrel dogs were used, weighing between 4 and 20 Kg ande between 1 and 6 years old. All received butorphanos and etomidate, both intravenously ins doses of 0,4mg/Kg to 2 mg/Kg respectively. We assessed cardiovascular, blood gas ventilometric and analgesia. The physiological parameters evaluated did not differ between the groups using different doses of lidocaine. For analgesia, 25% of animals in G4 had a pain score considered insufficient. However, it is conclused that two doses os…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Nunes, Newton [UNESP].

Subjects/Keywords: Analgesia; Lidocaína; Anestesia epidural; Epidural anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gering, A. P. [. (2012). Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/88968

Chicago Manual of Style (16^th Edition):

Gering, Ana Paula [UNESP]. “Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia.” 2012. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 11, 2021. http://hdl.handle.net/11449/88968.

MLA Handbook (7^th Edition):

Gering, Ana Paula [UNESP]. “Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia.” 2012. Web. 11 Apr 2021.

Vancouver:

Gering AP[. Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11449/88968.

Council of Science Editors:

Gering AP[. Avaliação de duas doses de lidocaína, administradas à altura da primeira vértebra lombar sobre a analgesia trans-cirúrgica e parâmetros cardiorrespiratórios em cadelas submetidas à ovariohisterectomia. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2012. Available from: http://hdl.handle.net/11449/88968

2. Bruno Gregnanin Pedron. Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos.

Degree: 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-19112013-140614/

► A espécie leporina vem sendo utilizada de forma ampla como modelo experimental em diversas áreas da medicina e medicina veterinária. A escassez de estudos publicados… (more)

▼ A espécie leporina vem sendo utilizada de forma ampla como modelo experimental em diversas áreas da medicina e medicina veterinária. A escassez de estudos publicados nesta área torna questionável a utilização ética da espécie em experimentos cirúrgicos. O objetivo foi determinar a duração dos bloqueios motor e sensitivo da lidocaína e bupivacaína administradas pela via peridural sacrococcígea e lombossacra e seus efeitos cardiovasculares e respiratórios associados a anestesia geral inalatória em coelhos submetidos a orquiectomia. Foram utilizados 30 animais da espécie leporina, raça Nova Zelândia Branco, pesando entre 2,350 e 3,300 kg, distribuídos em cinco grupos experimentais. O grupo Lido LS recebeu 0,3 ml/kg de lidocaína a 2% pela via peridural lombossacra; o grupo Lido SC recebeu 0,3 ml/kg de lidocaína a 2% pela via peridural sacrococcígea; o grupo Bupi LS recebeu 0,3 ml/kg de bupivacaína a 0,5% pela via peridural lombossacra; o grupo Bupi SC recebeu 0,3 ml/kg de bupivacaína a 0,5% pela via peridural sacrococcígea e o grupo Controle recebeu 0,3 ml/kg de solução fisiológica pela via peridural lombossacra. A administração peridural foi realizada por meio de punção simples com agulha hipodérmica. Na primeira parte do experimento, os animais foram anestesiados com sevofluorano em oxigênio a 100% com auxílio de máscara, e após a administração do protocolo de cada grupo, os reflexos sensitivos foram testados por meio de pinçamento dos dermátomos cutâneos e dos dígitos dos membros pélvicos e cauda. Os reflexos motores foram avaliados por meio de escore de tônus muscular dos membros pélvicos e cauda. Esta fase teve como objetivo determinar a duração e padrão de dispersão do bloqueio sensitivo e motor. Duas semanas após a determinação da duração do bloqueio sensitivo e motor, os animais foram anestesiados com isofluorano em máscara, intubados, e a administração do mesmo protocolo de anestesia peridural foi realizada para a realização de orquiectomia. A frequência cardíaca, frequência respiratória, pressão arterial sistólica, média e diastólica, concentração de dióxido de carbono ao fim da expiração, concentração de isofluorano inspirado e expirado, saturação de oxihemoglobina e temperatura corpórea foram monitorados a cada 10 min durante 50 min. Logo após a administração peridural e ao fim do procedimento, uma amostra de sangue arterial foi colhida para avaliação hemogasométrica. A dispersão, avaliada pelo número de dermátomos bloqueados, nos grupos que receberam a administração lombossacra foi maior que nos grupos de administração sacrococcígea. O período médio de bloqueio sensitivo com a lidocaína foi de 70±13,78 min pela via lombossacra e 60,83±23,11 min pela via sacrococcígea. Com a administração de bupivacaína pela via lombossacra, a duração do bloqueio sensitivo foi de 199,16±15,30 min e pela via sacrococcígea foi de 168,33±44,57 min. O grupo controle teve maior consumo de anestésico geral e maior requerimento de analgésico trans-operatório e de fármacos vasoativos durante o procedimento, demonstrando analgesia… Advisors/Committee Members: Silvia Renata Gaido Cortopassi, Andreza Conti Patara, Angelo João Stopiglia.

Subjects/Keywords: Anestesia; Coelhos; Peridural; Anesthesia; Epidural; Rabbits

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pedron, B. G. (2013). Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10137/tde-19112013-140614/

Chicago Manual of Style (16^th Edition):

Pedron, Bruno Gregnanin. “Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos.” 2013. Masters Thesis, University of São Paulo. Accessed April 11, 2021. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-19112013-140614/.

MLA Handbook (7^th Edition):

Pedron, Bruno Gregnanin. “Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos.” 2013. Web. 11 Apr 2021.

Vancouver:

Pedron BG. Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Apr 11]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-19112013-140614/.

Council of Science Editors:

Pedron BG. Avaliação da administração peridural sacrococcígea e lombossacra de lidocaína e bupivacaína em coelhos. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/10/10137/tde-19112013-140614/

3. Ishiy, Helcya Mime [UNESP]. Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica.

Degree: 2001, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/86637

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A anestesia epidural empregando-se anestésicos locais normalmente produz anestesia apenas da região retro umbilical. O trabalho investiga e compara o uso da lidocaína isolada ou associada ao butorfanol ou à quetamina, em anestesia epidural lombo-sacra de cães, no seu aspecto cardiorrespiratório e analgésico. Todos os animais foram tranquilizados com 0,1 mg/kg de acepromazina IV. Na primeira fase, seis cães adultos, foram anestesiados, em três ocasiões distintas, em ordem aleatória, com: 5 mg/kg lidocaína 2% com vasoconstritor (GAL); 1 mg/kg de quetamina (GAQ) e 0,1 mg/kg de butorfanol (GAB), nestes dois últimos complementando-se o volume de 1 ml/4 kg com lidocaína 2% com vasoconstritor. Foram avaliados: freqüência cardíaca, pressão arterial sistólica, freqüência respiratória, concentração expirada de CO2, volume minuto e corrente e temperatura retal. Ainda observou-se período de latência, duração do bloqueio, região bloqueada, duração da cirurgia e grau de miorrelaxamento. Na segunda fase, dezoito cadelas foram divididas em três grupos de mesmo número, anestesiadas com os mesmos protocolos anestésicos da primeira fase (GCL, GCQ, GCB) e submetidas à ovariosalpingohisterectomia. Para análise estatística dos dados paramétricos foram utilizadas a análise de variância, seguida do teste de Student-Newman-Keuls, para comparação entre momentos. Para comparação entre grupos, foi utilizado o teste T. Para as variáveis não paramétricas...

The aim of this study was to compare the cardiorespiratory effects and duration of lumbosacral epidural anaesthesia produced by lidocaine alone or combined with ketamine or butorphanol in dogs submitted or not to ovariohysterectomy. In the first stage, six mixed breed adult dogs (mean weight 14,0 ± 3,1 kg) were used in three different occasions: lidocaine 2% with adrenaline – 5 mg/kg (GAL), ketamine – 1 mg/kg (GAQ) or butorphanol – 0,1 mg/kg (GAB). In groups GAQ and GAB, the total volume of 1 ml/4 kg was completed with lidocaine. Heart heat, sistolic arterial blood pressure, respiratory rate, expired CO2, tidal and minute volume and rectal temperature were measured 15 minutes after pre-medication and every 30 minutes after epidural anesthesia until 120 minutes. The time to loss the interdigital reflex, duration and region of block were observed. In the second stage, eighteen mixed breed female dogs (mean weight 13,4 ± 3,5 kg) were divided in three groups(GCQ, GCB and GCL), anaesthetised as before and submitted to ovariohysterectomy. All animals were sedated with acepromazine 0,1 mg/kg IV. Data were analysed using ANOVA, followed by Student-Newman-Keuls test or Kruskal-Wallis and Friedman tests as appropriate. The rectal temperature reduced in all groups. Muscle relaxation was better in the GCQ and GCB groups than the in GCL group.…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Luna, Stelio Pacca Loureiro [UNESP].

Subjects/Keywords: Anestesia; Epidural anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ishiy, H. M. [. (2001). Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/86637

Chicago Manual of Style (16^th Edition):

Ishiy, Helcya Mime [UNESP]. “Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica.” 2001. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 11, 2021. http://hdl.handle.net/11449/86637.

MLA Handbook (7^th Edition):

Ishiy, Helcya Mime [UNESP]. “Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica.” 2001. Web. 11 Apr 2021.

Vancouver:

Ishiy HM[. Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2001. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11449/86637.

Council of Science Editors:

Ishiy HM[. Uso da lidocaína isolada ou associada à quetamina ou ao butorfanol, em anestesia epidural em cães: avaliação cardiorrespiratória e analgésica. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2001. Available from: http://hdl.handle.net/11449/86637

Universidade Estadual de Campinas

4. Junqueira, Fernando Eduardo Féres, 1988-. Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Farmacologia, 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332611

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Orientador: Angélica de Fátima de Assunção Braga

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-10-24T17:32:03Z (GMT).… (more)

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Orientador: Angélica de Fátima de Assunção Braga

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

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Resumo: Na literatura são poucos os estudos que avaliam a influência dos anestésicos locais por via peridural na farmacodinâmica dos bloqueadores neuromusculares. Nenhum desses estudos avaliou a associação da ropivacaína com o rocurônio. Neste estudo avaliou-se a influência da ropivacaína por via peridural sobre as características farmacodinâmicas do rocurônio. Trata-se de um ensaio clínico, aberto, comparativo e aleatorizado. Foram incluídas 60 pacientes estado físico ASA 1 e 2, atendidas no Hospital da Mulher Prof. Dr. José Aristodemo Pinotti ¿ CAISM ¿ UNICAMP, programadas para cirurgias abdominais eletivas sob anestesia geral com ventilação controlada mecânica, distribuídas em 2 grupos: Grupo 1 (anestesia geral associada à peridural) e Grupo 2 (anestesia geral). A técnica de anestesia geral foi a mesma em ambos os grupos (sufentanil, propofol e remifentanil em infusão contínua, rocurônio ¿ 0,6 mg.kg-1 e mistura de óxido nitroso:oxigênio ¿ 50%). No Grupo 1, administrou-se ropivacaína a 0,2% na dose de 40 mg (20 ml) associada a 2mg (2ml) de morfina por via peridural. Foram avaliados os seguintes parâmetros: duração clínica (DC25), índice de recuperação (IR25-75) do rocurônio e tempo para recuperação de razão TOF0,9 (T4/T1 = 90%). Para comparação das variáveis categóricas entre os 2 grupos foram utilizados os testes Qui-Quadrado. Os valores médios obtidos para as variáveis PAM e FC foram comparados entre os grupos nos diferentes tempos estudados empregando-se o teste t de Student. Para comparação dessas médias ao longo dos tempos estudados (intragrupo) utilizou-se o teste MANOVA. Para comparação das demais variáveis numéricas entre os 2 grupos foi utilizado o teste U de Mann-Whitney, devido à ausência de distribuição normal. Adotou-se um nível de significância de 5% (p<0,05). Os valores da mediana, do primeiro (Q1) e terceiro (Q3) quartis (min) nos dois grupos para: DC25 foram, respectivamente: 41,5; 35,0; e 55,0 no grupo 1; e 44,0; 37,0; e 51,0 no grupo 2 (p=0,88); IR25-75 foram, respectivamente: 20,5; 14,0; e 28,0 no grupo 1; e 15,5; 10,0; e 24; no grupo 2 (p=0,15); TOF0,9 foram, respectivamente: 88,0; 67,0; e 99,0 no grupo 1; e 80,0; 71,0; e 86,0 no grupo 2 (p=0,83), sem diferença significativa entre os grupos. A ropivacaína por via peridural, na dose estudada, não prolongou a duração do bloqueio neuromuscular produzido pelo rocurônio

There are few studies published addressing the influence of epidurally administered local anesthetics and the pharmacodynamics of the neuromuscular blocking agents. None of those trials has studied the association between the ropivacaine and the rocuronium. The following study is a randomized, non-blinded clinical trial. This trial…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Braga, Angélica de Fátima de Assunção, 1952-, Brandão, Maria José Nascimento, Modolo, Norma Sueli Pinheiro.

Subjects/Keywords: Rocurônio; Ropivacaína; Anestesia epidural; Anestesia geral; Farmacocinética; Rocuronium; Ropivacaine; Epidural anesthesia; General anesthesia; Pharmacodynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junqueira, Fernando Eduardo Féres, 1. (2018). Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332611

Chicago Manual of Style (16^th Edition):

Junqueira, Fernando Eduardo Féres, 1988-. “Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado.” 2018. Masters Thesis, Universidade Estadual de Campinas. Accessed April 11, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332611.

MLA Handbook (7^th Edition):

Junqueira, Fernando Eduardo Féres, 1988-. “Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado.” 2018. Web. 11 Apr 2021.

Vancouver:

Junqueira, Fernando Eduardo Féres 1. Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Apr 11]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332611.

Council of Science Editors:

Junqueira, Fernando Eduardo Féres 1. Influência da ropivacaína por via peridural, nas características farmacodinâmicas do rocurônio : ensaio clínico aleatorizado. [Masters Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332611

Rhode Island College

5. Keker, Lana. Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery.

Degree: MSN, 2016, Rhode Island College

URL: https://digitalcommons.ric.edu/etd/172

► Coronary artery bypass graft (CABG) surgery is the most common type of heart surgery in the United States. The main benefit of CABG surgery… (more)

▼ Coronary artery bypass graft (CABG) surgery is the most common type of heart surgery in the United States. The main benefit of CABG surgery is a significant decrease in myocardial infarction rate, while the most common complications of CABG are myocardial damage and atrial fibrillation. The incorporation of epidural anesthesia occurred in order to decrease sympathetic nervous system response during CABG but has not been extensively studied. A systematic review was conducted to compare the cardiovascular outcomes of the addition of thoracic epidural anesthesia to the anesthetic plan versus general anesthesia as a solo technique during coronary artery bypass grafting surgery. The PubMed database was searched to identify randomized controlled trials in adult patients undergoing CABG with implementation of thoracic epidural anesthesia versus general anesthesia only. Seven studies involving 668 participants met the criteria. A previously published meta- analysis of randomized controlled trials was also included. The Preferred Reporting Items for Systematic Review (PRISMA) checklist was utilized to extrapolate and synthetize the data. The Critical Appraisal Sheet for Controlled Randomized Studies was adapted from the FRISBE tool in order to compare both within and across the studies. Two outcomes were measured: the degree of cardiac damage that was represented by troponin level and atrial fibrillation rate. The limited evidence suggested that thoracic epidural anesthesia does not provide cardioprotective benefits in adult patients undergoing CABG. The results of the study should be interpreted with caution due to the limited information available and heterogeneity of the studies. The question of whether thoracic epidural anesthesia provides cardioprotective functions requires further investigation. Taking into consideration the results of this study, it is not recommended to use the epidural anesthesia as an adjunct technique on the routine basis during CABG until more information is available.

Subjects/Keywords:

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keker, L. (2016). Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery. (Masters Thesis). Rhode Island College. Retrieved from https://digitalcommons.ric.edu/etd/172

Chicago Manual of Style (16^th Edition):

Keker, Lana. “Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery.” 2016. Masters Thesis, Rhode Island College. Accessed April 11, 2021. https://digitalcommons.ric.edu/etd/172.

MLA Handbook (7^th Edition):

Keker, Lana. “Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery.” 2016. Web. 11 Apr 2021.

Vancouver:

Keker L. Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery. [Internet] [Masters thesis]. Rhode Island College; 2016. [cited 2021 Apr 11]. Available from: https://digitalcommons.ric.edu/etd/172.

Council of Science Editors:

Keker L. Comparison of Outcomes of Combined Thoracic Epidural Anesthesia with General Anesthesia Versus General Anesthesia During Coronary Artery Bypass Graft Surgery. [Masters Thesis]. Rhode Island College; 2016. Available from: https://digitalcommons.ric.edu/etd/172

6. VILLELA, Ana Carolina Vasques. Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães.

Degree: 2012, Universidade Federal de Goiás; Mestrado em Ciência Animal; UFG; BR; Ciências Agrárias – Veterinaria

URL: http://repositorio.bc.ufg.br/tede/handle/tde/886

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Made available in DSpace on 2014-07-29T15:07:41Z (GMT). No. of bitstreams: 1 Dissertacao Ana Carolina Vasques Villela.pdf: 1200187 bytes, checksum: e80340dfd98ca2e1e517f50dcd0bef34 (MD5) Previous issue date: 2012-02-24… (more)

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Made available in DSpace on 2014-07-29T15:07:41Z (GMT). No. of bitstreams: 1 Dissertacao Ana Carolina Vasques Villela.pdf: 1200187 bytes, checksum: e80340dfd98ca2e1e517f50dcd0bef34 (MD5) Previous issue date: 2012-02-24

A anestesia local se popularizou na medicina veterinária no século XX, mas alguns de seus recursos, como o cateter epidural e as soluções hiperbáricas, bastante utilizados no homem atualmente ainda são pouco estudados e aplicados em animais. Em seguida, outro estudo verificou a qualidade da anestesia epidural toracolombar com lidocaína a 2% ou hiperbárica a 5% e a influência do decúbito e o do tempo de permanência do cateter epidural na qualidade deste bloqueio. Para isso foram usados sete cães machos, adultos, pesando 12,76 +/-2,59 kh. Com os animais até o espaço T13-L1, tendo seu dispositivo sepultado no tecido subcutâneo. Em seguida, administrou-se 4 mg/kg de lidocaína isobárica a 2% com os animais em posição quadrupedal(IQ4) ou em decúbito lateral (IL4); 3 mg/kg de lidocaína hiperbárica a 5% em posição quadrupedal (HQ3) ou em decúbito lateral (HL3); e 4 mg/kg de lidocaína hiperbárica a 5% em posição quadupedal (HQ4) ou em decúbito lateral (HL4). Foram avaliadas a viabilidade da técnica de implantação; a ocorrência de complicações após a implantação ou retirada do cateter epidural; o tempo de permanência do cateter epidural; os efeitos da administração de lidocaína a 2% ou hiperbárica a 5% sobre a FC, , PAS, SPO2 e TR; a a qualidade do bloqueio anestésico (latência, extensão, simetria e duração do bloqueio anestésico); influência do decúbito e do tempo de permanência do cateter na qualidade do bloqueio anestésico. A implantação do cateter epidural foi viável e isenta de complicações; houve redução significativa somente nos valores de e TR em relação ao valor basal nos grupos IQ4, IL4, HQ3, HL3,HQ4. Não foram observadas diferenças significativas na FC, PAS, SPO2, latência, duração e extensão do bloqueio entre os grupos. O decúbito não influenciou significativamente a qualidade do bloqueio. O tempo de permanência do cateter no espaço epidural influenciou significativamente a duração máxima do bloqueio sensitivo. Em conclusão, o modelo descrito para implantação do cateter epidural é viável, porém o tempo que o cateter permaneceu no espaço epidural influenciou a duração do bloqueio anestésico e a lidocaína hiperbárica a 5% não mostrou vantagens em relação ao uso da lidocaína isobárica a 2% na anestesia epidural toracolombar.

Advisors/Committee Members: MORENO, Juan Carlos Duque, BORGES, Naída Cristina, ALVES, Rosangela de Oliveira.

Subjects/Keywords: Analgesia/anestesia epidural; caninos; fibrose epidural; implantação epidural; complicações; hiperbárica; cateter epidural; analgesia/anesthesia epidural; canine; epidural firbrosis; canine; epidural fibrosis; epidural implantation; complications; hyperbaric; epidural catheter; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

VILLELA, A. C. V. (2012). Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães. (Masters Thesis). Universidade Federal de Goiás; Mestrado em Ciência Animal; UFG; BR; Ciências Agrárias – Veterinaria. Retrieved from http://repositorio.bc.ufg.br/tede/handle/tde/886

Chicago Manual of Style (16^th Edition):

VILLELA, Ana Carolina Vasques. “Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães.” 2012. Masters Thesis, Universidade Federal de Goiás; Mestrado em Ciência Animal; UFG; BR; Ciências Agrárias – Veterinaria. Accessed April 11, 2021. http://repositorio.bc.ufg.br/tede/handle/tde/886.

MLA Handbook (7^th Edition):

VILLELA, Ana Carolina Vasques. “Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães.” 2012. Web. 11 Apr 2021.

Vancouver:

VILLELA ACV. Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães. [Internet] [Masters thesis]. Universidade Federal de Goiás; Mestrado em Ciência Animal; UFG; BR; Ciências Agrárias – Veterinaria; 2012. [cited 2021 Apr 11]. Available from: http://repositorio.bc.ufg.br/tede/handle/tde/886.

Council of Science Editors:

VILLELA ACV. Anestesia epidural toracolombar com lidocaína a 2% ou lidocaína hiperbárica a 5% pelo uso de cateter epidural totalmente implantado em cães. [Masters Thesis]. Universidade Federal de Goiás; Mestrado em Ciência Animal; UFG; BR; Ciências Agrárias – Veterinaria; 2012. Available from: http://repositorio.bc.ufg.br/tede/handle/tde/886

Universitat Autònoma de Barcelona

7. Aguilera i Cuchillo, Lluís. Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana.

Degree: Departament de Cirurgia, 2019, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/669350

► Background and objectives: Cough pressure (PCOUGH), as expression of expiratory muscle strength, is usually measured with esophageal (gold-standard) or gastric balloons, but these catheters can… (more)

▼ Background and objectives: Cough pressure (PCOUGH), as expression of expiratory muscle strength, is usually measured with esophageal (gold-standard) or gastric balloons, but these catheters can be uncomfortable for the patient or their placement impractical. Furthermore, the effects of epidural anesthesia and laparotomy on PCOUGH are unknown. This study aimed to: 1/ find alternatives to esophageal and gastric balloons to measure PCOUGH, 2/ measure the effect of epidural analgesia on cough strength, and 3/ measure the effect of midline laparotomy on cough strength, without the interference of postoperative pain. Methods: Prospective observational study of patients scheduled for colon surgery via midline laparotomy, and articulated in 3 protocols: 1/ Protocol 1 (9 patients): comparison of PCOUGH measurement in different anatomical locations (esophagus, stomach, superior vena cava, bladder and rectum), 2/ Protocol 2 (14 patients): measurement of the effects of thoracic epidural bupivacaine 0.25% on PCOUGH and 3/ Protocol 3 (11 patients): measurement of the effects of midline laparotomy on PCOUGH, without the influence of pain or systemic anesthetic drugs. Prior to surgery, an epidural catheter was placed at T8-T10 level as well as catheters in the anatomical locations under study. In supine position, patients were asked to cough as forcefully as possible while PCOUGH was recorded. Afterward, epidural 0.25% bupivacaine with adrenaline 1:200.000 was administered until T6 sensory level was obtained, and PCOUGH was measured again. After surgery, the same dose of bupivacaine 0.25% used in Protocol 2 was administered and PCOUGH measurements were repeated. PCOUGH of the first studied subjects was measured in all anatomical locations and when results of Protocol 1 were obtained, the study was continued using the least unpleasant alternative catheter. The intraclass correlation coefficient, Bland–Altman plots and Wilcoxon signed-rank test were used as statistical analyses. Results: PCOUGH [cmH2O, median (1st quartil, 3rd quartil)]: esophagus 112 (89,148), stomach 105 (92,156), superior vena cava 102 (91,149), bladder 118 (93,157), and rectum 103 (88,150), showing excellent within-site repeatability of the measurements (p < 0.001) and excellent agreement between pressures recorded at superior cava and rectum and recorded at esophagus (p < 0.004). Bladder pressure was precise but slightly higher. Rectal catheter was the least unpleasant alternative. Epidural 0.25% bupivacaine decreased PCOUGH by 16% (p = 0.001), while significant changes in PCOUGH measurement were not observed after midline laparotomy. Conclusions: PCOUGH can be measured in the esophagus, stomach, superior vena cava or rectum, since their values are similar. It can also be measured in the bladder, although the value will be slightly higher. The rectal catheter was the least unpleasant. Thoracic epidural bupivacaine 0.25% (anesthetic level T6) significantly decreases cough pressure. Midline laparotomy does not change cough pressure if thoracic epidural… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Gallart i Gallego, Lluís (director).

Subjects/Keywords: Tos; Cough; Anèstesia epidural; Anestesia epidural; Epidural anesthesia; Laparatomia media; Laparotomia mediana; Midiline laparotomy; Ciències de la Salut; 617

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aguilera i Cuchillo, L. (2019). Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/669350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aguilera i Cuchillo, Lluís. “Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana.” 2019. Thesis, Universitat Autònoma de Barcelona. Accessed April 11, 2021. http://hdl.handle.net/10803/669350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aguilera i Cuchillo, Lluís. “Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana.” 2019. Web. 11 Apr 2021.

Vancouver:

Aguilera i Cuchillo L. Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10803/669350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aguilera i Cuchillo L. Pressió generada per la tos. tècniques alternatives de mesura i efectes de l’analgèsia epidural i la laparotomia mediana. [Thesis]. Universitat Autònoma de Barcelona; 2019. Available from: http://hdl.handle.net/10803/669350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Καλογεράς, Νικόλαος. PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση.

Degree: 2012, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/29404

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Objectives: To evaluate the possibility of performing percutaneous nephrolithotomy (PCNL) under epidural anesthesia and epidural analgesia and to compare these techniques to each other and… (more)

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Objectives: To evaluate the possibility of performing percutaneous nephrolithotomy (PCNL) under epidural anesthesia and epidural analgesia and to compare these techniques to each other and to general anesthesia. The three anesthetic techniques were compared to their perioperative results, complications, postoperative pain nausea and vomiting and also to patient satisfaction.Design: prospective randomized trial. Patients and Methods: One hundred and ten (110) patients requiring PCNL were enrolled in the study. They all fulfilled the following inclusion criteria:American Society of Anesthesiologists’ status up to III, older than 18 years of age, body mass index (calculated as weight in kilograms divided by height in meters squared) of 30 or less, and normal coagulation profile. Exclusion criteria were allergy to opiates or to local anesthetics, uncorrected coagulopathy. All patients did not have problems requiring medical or psychiatric intervention, nor did they have a history of psychotic illness, current alcohol and/or drug abuse, or dementia.Only 98 patients were correctly randomized. Thirty two of them received general anesthesia (Group A), thirty four of them received epidural analgesia (Group B) and thirty two received epidural anesthesia (GroupΓ).All patients received one hour prior to surgery 1000mg paracetamol and 40mg parecoxib.The PCNL was performed in the prone position. Percutaneous renal tract access wascreated with ultrasound guidance.Results: The three groups were similar regarding demographics. All the procedures were completed by the allocated method of anesthesia.It was proved that the group of epidural analgesia had significant less fall to the mean blood pressure during the procedure, in the same group the pain assessed by the visual analog scale was significantly less at 4, 8, 12, and 24 hours postoperatively. The group of epidural analgesia had also less vomiting and dizziness. The overall complications were significant less in the epidural analgesia group. More than half of the patients in Group B were absolutely satisfied from the anesthesia. Conclusions: The analysis of our study not only confirmed the feasibility and safely of performing PCNL under epidural anesthesia and epidural analgesia as the sole anesthetic procedure but also showed the superiority of epidural analgesia comparedwith the standard general anesthesia and epidural anesthesia.

Σκοπός αυτής της προοπτικής, τυχαιοποιημένης μελέτης ήταν να καταδειχθεί ότι είναι δυνατόν να εκτελεσθεί PCNL με αναισθητικές τεχνικές εκτός των κλασσικών (Γενικής αναισθησίας) και κατόπιν να συγκριθούν οι τεχνικές ως προς την περιεγχειρητική έκβαση, επιπλοκές, μετεγχειρητικό πόνο, ικανοποίηση του ασθενούς ναυτία και εμετό.Ασθενείς και μέθοδος Το πλήθος του δείγματος των ασθενών είναι 110 (n=110). Από αυτούς οι 98 χωρίστηκαν με τυχαίο τρόπο σε 3 ομάδες και έλαβαν διαφορετικό είδος αναισθησίας. Συγκεκριμένα:1η ομάδα αποτελούμενη από 32 ασθενείς έλαβε γενική αναισθησία2η ομάδα αποτελούμενη από 34 ασθενείς έλαβε επισκληρίδιο αναλγησίαo3η…

Subjects/Keywords: ΔΙΑΔΕΡΜΙΚΗ ΝΕΦΡΟΛΙΘΟΤΡΙΨΙΑ; Επισκληρίδια αναλγησία; ΕΠΙΣΚΛΗΡΙΔΙΑ ΑΝΑΙΣΘΗΣΙΑ; Γενική αναισθησία; PCNL (Percutaneus nephrolithotomy); Epidural analgesia; Epidural anesthesia; General anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Καλογεράς, . �. (2012). PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/29404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Καλογεράς, Νικόλαος. “PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση.” 2012. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed April 11, 2021. http://hdl.handle.net/10442/hedi/29404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Καλογεράς, Νικόλαος. “PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση.” 2012. Web. 11 Apr 2021.

Vancouver:

Καλογεράς �. PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10442/hedi/29404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Καλογεράς �. PCNL υπό επισκληρίδια αναλγησία VS PCNL υπό επισκληρίδια αναισθησία VS PCNL υπό γενική αναισθησία: επίδραση στη διεγχειρητική και μετεγχειρητική έκβαση. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2012. Available from: http://hdl.handle.net/10442/hedi/29404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

9. Souza, Márcio Antonio de, 1950-. Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS).

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Tocoginecologia, 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333179

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Orientador: Maria Laura Costa do Nascimento

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

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Orientador: Maria Laura Costa do Nascimento

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2019-02-08T18:48:12Z (GMT). No. of bitstreams: 1 Souza_MarcioAntonioDe_D.pdf: 1405339 bytes, checksum: cae0c8c99cbd8ba8af93d66c272414dd (MD5) Previous issue date: 2018

Resumo: Introdução: Trabalho de parto e parto são fenômenos fisiológicos, extremamente dolorosos para a maioria das mulheres, sendo a intensidade da dor influenciada por características individuais e socioculturais. Há diferenças no uso e na disponibilidade de métodos de alívio da dor entre os países de baixa, média e alta renda, com menor uso de analgesia nos países de baixa renda, devido à influência cultural, custos, restrições de recursos e escassez de anestesiologistas. Além disso, existem novos desafios para a realização de anestesia/analgesia, com as mudanças nas características da população, incluindo taxas crescentes de obesidade materna, idade materna avançada e complexidade de doenças pré-existentes. Objetivos: Avaliar, em diferentes países e regiões do mundo, o uso de qualquer forma de analgesia para partos vaginais, seus fatores associados e resultados maternos e perinatais, em casos com e sem morbidade materna grave. Métodos: análise secundária do estudo: World Health Organization Multicountry Survey on Maternal and Newborn Health (WHO-MCS). Este estudo foi um corte transversal empreendido pela Organização Mundial da Saúde entre 01 de maio de 2010 e 31 de dezembro de 2011, incluindo 357 unidades de saúde em 29 países (África, Ásia, América Latina e Oriente Médio). O principal objetivo do WHO-MCS foi caracterizar a morbidade materna, perinatal e neonatal grave a partir da vigilância em uma rede mundial de unidades de saúde. Para o estudo atual foram incluídas todas as mulheres que tiveram parto vaginal com idade gestacional superior a 22 semanas e com peso do recém nascido superior a 500 gramas. Foram excluídas as mulheres com diagnóstico de óbito fetal tardio/macerado. Foram realizadas 2 análises, a primeira para descrição do uso de analgesia nos diversos países do estudo e segundo Índice de Desenvolvimento Humano (IDH), com descrição geral de resultados maternos e perinatais de casos com e sem analgesia e avaliação de fatores associados à realização do procedimento anestésico. A segunda análise visou a avaliação do uso de analgesia dentre os casos de morbidade materna grave. Resultados: Das 314.623 mulheres incluídas, 221.345 tiveram partos vaginais e, dessas, apenas 4% foram submetidas à analgesia de parto, sendo a maioria originária de países com IDH mais elevados. Os fatores associados de maneira independente a maior realização de analgesia foram: nuliparidade, maior escolaridade, cesárea prévia, baixo peso ao nascer e prematuridade. Na análise de mulheres com morbidade materna grave e parto vaginal, o uso da analgesia não se mostrou como fator preditor ou associado à pior resultado materno (Nearmiss materno-NMM e morte materna-MM), no entanto, mulheres com…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Nascimento, Maria Laura Costa do, 1979-, Lajos, Giuliane Jesus, Tedesco, Ricardo Porto, Braz, José Reinaldo Cerqueira, Silva, João Luiz de Carvalho Pinto e.

Subjects/Keywords: Analgesia; Parto normal; Anestesia epidural; Morbidade materna grave; Analgesia; Natural childbirth; Anesthesia, Epidural; Severe maternal morbidity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, Márcio Antonio de, 1. (2018). Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS). (Masters Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/333179

Chicago Manual of Style (16^th Edition):

Souza, Márcio Antonio de, 1950-. “Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS).” 2018. Masters Thesis, Universidade Estadual de Campinas. Accessed April 11, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/333179.

MLA Handbook (7^th Edition):

Souza, Márcio Antonio de, 1950-. “Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS).” 2018. Web. 11 Apr 2021.

Vancouver:

Souza, Márcio Antonio de 1. Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS). [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Apr 11]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333179.

Council of Science Editors:

Souza, Márcio Antonio de 1. Analgesia para parto vaginal : análise secundária do Estudo Multi-países da Organização Mundial de Saúde Materna e Neonatal = Analgesia for vaginal birth: secondary analysis from the WHO Multicountry Study on Maternal and Newborn Health (WHO-MCS). [Masters Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/333179

10. Albuquerque, Verônica Batista de [UNESP]. Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia.

Degree: 2008, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/86643

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A utilização da anestesia local peridural tem alcançado grande ênfase nos últimos anos, sobretudo com a utilização de opióides. O presente trabalho teve como objetivo investigar a utilização da ropivacaína isolada ou em associação a diferentes opióides, na anestesia peridural de cadelas submetidas à ovariosalpingohisterectomia (OSH) eletiva. Participaram do estudo duplamente encoberto 32 cadelas sadias, adultas, de diferentes raças, pesando entre seis e 15 kg e pré-medicadas com acepromazina (0,05mg/kg, IM) associada ao midazolam (0,2mg/kg, IM), distribuídas em quatro grupos distintos: Grupo 1: ropivacaína: 0,3 mL/kg; Grupo 2: ropivacaína + morfina (0,1 mg/kg); Grupo 3: ropivacaína + butorfanol (0,1 mg/kg); e Grupo 4: ropivacaína + tramadol (0,5 mg/kg) administrados pela via peridural. Em cada momento experimental foram mensurados: freqüência cardíaca; freqüência respiratória; pressão arterial sistólica; temperatura retal; pressão parcial dos gases sangüíneos (arterial); pH sangüíneo; além da avaliação não-paramétrica do grau de sedação, grau de sangramento e de relaxamento muscular seguindo tabelas de escores. Os dados foram submetidos à ANOVA e comparados pelos testes de Kruskal-Wallis, Friedman, Dunn e Tukey (p< 0,05). Concluiu-se que a utilização da ropivacaína isolada ou associada à morfina, ao butorfanol ou ao tramadol pela via peridural não promoveu depressão cardiorrespiratória ou alterações hemodinâmicas significativas, sendo que a ropivacaína associada ao butorfanol permitiu a realização de OSH em cadelas.

The use of epidural local anesthesia has been reaching great emphasis for the last years, overcoat with the opioids using. This research ained the use of ropivacaine with or without association the different opioids, for epidural anesthesia biches submitted the elective ovariosalpingohisterectomy (OSH). 32 bitches tool part is this double-blind study, adult, different breed, weighing between 6 and 15kg and pré-medicated with acepromazine (0.05mg/kg, IM) associated to the midazolam (0.2mg/kg, IM), distributed in for different groups: Group 1: ropivacaine: 0.3 mL/kg; Group 2: ropivacaine + morphine (0.1 mg/kg); Group 3: ropivacaine + butorphanol (0.1 mg/kg); and Group 4: ropivacaine + tramadol (0.5 mg/kg) administered epidural. The following parameters were studied: heart frequency; breathing frequency; systolic arterial pressure; rectal temperature; blood gas partial pressures (arterial); blood pH; besides non-parametric of sedation grade, bleeding grade and muscular relaxation following tables scores. The results were submitted by ANOVA and compared by Kruskal-Wallis, Friedman, Dunn and Tukey test (p< 0.05). It was conclude that the use of only ropivacaine or associated with morphine, with butorphanol or tramadol for the epidural…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Oliva, Valeria Nobre Leal de Souza [UNESP].

Subjects/Keywords: Opioides; Anestesia epidural; Analgésicos opióides; Analgesics, Opioid; Anesthesia, Epidural

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Albuquerque, V. B. d. [. (2008). Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/86643

Chicago Manual of Style (16^th Edition):

Albuquerque, Verônica Batista de [UNESP]. “Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia.” 2008. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 11, 2021. http://hdl.handle.net/11449/86643.

MLA Handbook (7^th Edition):

Albuquerque, Verônica Batista de [UNESP]. “Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia.” 2008. Web. 11 Apr 2021.

Vancouver:

Albuquerque VBd[. Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2008. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11449/86643.

Council of Science Editors:

Albuquerque VBd[. Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de ovariosalpingohisterectomia. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2008. Available from: http://hdl.handle.net/11449/86643

11. Silva, Bruno Monteiro da [UNESP]. Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães.

Degree: 2007, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/92199

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A anestesia peridural é amplamente difundida no meio veterinário, utilizando-se o anestésico local isolado ou associado aos opióides, capazes de promover aumento do efeito analgésico. A ropivacaína é um fármaco relativamente novo, ainda pouco utilizado em Veterinária. O fentanil é um opióide agonista e o tramadol é um opióide de ação mista. Neste experimento, oito cães foram tranqüilizados com acepromazina, submetidos à peridural com um dos protocolos a seguir: GR (ropivacaína), GRF (ropivacaína + fentanil), GRT (ropivacaína + tramadol), em volume total de 0,25 mL/kg. Durante o procedimento foram avaliados e comparados os seguintes parâmetros vitais (FC, f, temperatura retal, pressão arterial, e gasometria do sangue arterial), os bloqueios sensitivo e motor (latência e duração de ação), o grau de sedação, e a ocorrência de possíveis efeitos indesejáveis advindos da administração de ropivacaína isolada ou em associação. A diminuição mais intensa na FC ocorreu nos grupos GRF e GRT, e ocorreu hipotermia significativa nos animais do GRF. Todos os grupos apresentaram sedação, sendo severa nos grupos GRF e GRT. De maneira geral, o período de recuperação foi mais curto nos animais do grupo GRT do que nos demais. O GRT também foi o que apresentou bloqueio mais cranial. Foram observadas bradicardia, hipotermia e síndrome de Shiff- Sherrington no período trans-anestésico em animais de todos os grupos. Decorridas 24 horas de período pós-anestésico, não foram evidenciados efeitos indesejáveis, em nenhum dos grupos. GRF foi o grupo com maior duração de anestesia e analgesia, GRT apresentou a menor duração de anestesia com analgesia intermediária, e GR apresentou duração intermediária, com menor analgesia.

Peridural anesthesia is broadly applied in the Veterinary field, using the isolated local anesthetic or in combination with opiates capable to increase the analgesic effect. The ropivacaine is a relatively new drug, not much used in the Veterinary field yet. The fentanil is an agonist opiate and tramadol is a mixed action opiate. In this experiment, eight dogs were sedated with acepromazine and subjected to the epidural anesthesia with one of the following protocols: GR (ropivacaine), GRF (ropivacaine + fentanyl), GRT (ropivacaine + tramadol), in 0,25mL/Kg of total volume. During the procedure, following vital signs were evaluated and compared (heart rate, respiratory rate, rectal temperature, blood pressure and gasometry of arterial blood), the sensory and motor blockade (latency and length of action), level of sedation and the occurrence of possible side effects due to administration of ropivacaine individually or in combination with other drugs. The highest decrease in the heart rate occurred in the…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Oliva, Valeria Nobre Leal de Souza [UNESP].

Subjects/Keywords: Analgesia; Anestesia epidural; Analgésicos opióides; Anesthesia, Epidural

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, B. M. d. [. (2007). Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/92199

Chicago Manual of Style (16^th Edition):

Silva, Bruno Monteiro da [UNESP]. “Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães.” 2007. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 11, 2021. http://hdl.handle.net/11449/92199.

MLA Handbook (7^th Edition):

Silva, Bruno Monteiro da [UNESP]. “Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães.” 2007. Web. 11 Apr 2021.

Vancouver:

Silva BMd[. Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2007. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11449/92199.

Council of Science Editors:

Silva BMd[. Avaliação cardiorrespiratória e analgésica da ropivacaína isolada e associada ao fentanil ou ao tramadol, administrados pela via peridural em cães. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2007. Available from: http://hdl.handle.net/11449/92199

Universidade Estadual de Campinas

12. Souza, Marcio Antonio de. Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Tocoginecologia, 2009, Universidade Estadual de Campinas

URL: SOUZA, Marcio Antonio de. Analgesia de parto: bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. 2009. 91 f. Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/309851>. Acesso em: 13 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/309851

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Orientador: João Luiz de Carvalho Pinto e Silva

Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas

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Orientador: João Luiz de Carvalho Pinto e Silva

Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas

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Resumo: JUSTIFICATIVA E OBJETIVOS: O trabalho de parto produz desconforto e dor intensa à maioria das parturientes. O método de eleição que seria ideal para produzir analgesia deveria reduzir ao máximo os inconvenientes e a dor provocados pelo trabalho de parto, permitindo que a mãe participasse ativamente e com prazer da experiência de dar à luz. A analgesia combinada raqui-peridural (ACRP) apresentaria, como vantagens, a possibilidade de instalação precoce, rápido início de ação analgésica, uso de baixas doses de anestésicos locais, associando-se a trabalhos de partos mais curtos, menor bloqueio motor e ofereceria maior satisfação à parturiente. A analgesia peridural contínua (APC) utilizaria doses maiores de anestésicos locais, produzindo maior bloqueio motor, mas deveria ser realizada em fases mais adiantadas do período de dilatação. O potencial atrativo da ACRP seria o de incorporar as vantagens da administração intratecal de fármacos de ação analgésica rápida, com a manutenção de acesso através de um cateter peridural, disponível continuamente para complementação com novas doses ou adição de outras drogas, minimizando as desvantagens apresentadas por ambas as técnicas. O estudo compara os desfechos maternos e perinatais com a utilização da ACRP e APC em parturientes primigestas. SUJEITOS E MÉTODOS Foi realizado um ensaio clínico aleatorizado com 128 gestantes primigestas em trabalho de parto, divididas em dois grupos de igual tamanho (grupo APC e grupo ACRP) admitidas no pré-parto de duas maternidades na cidade de Jundiaí - SP, sendo estudadas as seguintes variáveis: tempo de latência de instalação da analgesia, intensidade da dor ao longo da analgesia, tempo total decorrido até a completa dilatação do colo uterino, Índice de Apgar de primeiro e quinto minutos, tempo de resolução do parto, grau de bloqueio motor, efeitos adversos como náuseas, vômitos, prurido, hipotensão arterial e o grau de satisfação materna. ANÁLISE DOS DADOS: A análise dos dados foi feita através do teste de Mann-Whitney para as variáveis contínuas não paramétricas. Utilizou-se também teste exato de Fisher e teste qui-quadrado de Pearson para variáveis categóricas. RESULTADOS: Não houve diferenças entre os grupos em relação à velocidade de dilatação cervical, tempo para resolução do parto, parâmetros hemodinâmicos maternos, vitalidade do recémnascido, complementações analgésicas durante o trabalho de parto e parto. Ocorreu maior rapidez de instalação da analgesia no grupo da ACRP. Com relação ao bloqueio motor também se observou diferença estatística significativa entre os dois grupos, sendo menor no grupo de APC. CONCLUSÕES: As duas técnicas mostraram-se seguras e eficientes, porém a ACRP ofereceu…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Silva, João Luiz de Carvalho Pinto e, 1944-, Filho, Nelson Lourenço Maia, Pereira, Rosa Inês Costa.

Subjects/Keywords: Analgesia; Anestesia epidural; Raquianestesia; Parto; Opioides; Analgesia; Epidural anesthesia; Spinal anesthesia; Delivery; Opioids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, M. A. d. (2009). Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. (Doctoral Dissertation). Universidade Estadual de Campinas. Retrieved from SOUZA, Marcio Antonio de. Analgesia de parto: bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. 2009. 91 f. Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/309851>. Acesso em: 13 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/309851

Chicago Manual of Style (16^th Edition):

Souza, Marcio Antonio de. “Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas.” 2009. Doctoral Dissertation, Universidade Estadual de Campinas. Accessed April 11, 2021. SOUZA, Marcio Antonio de. Analgesia de parto: bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. 2009. 91 f. Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/309851>. Acesso em: 13 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/309851.

MLA Handbook (7^th Edition):

Souza, Marcio Antonio de. “Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas.” 2009. Web. 11 Apr 2021.

Vancouver:

Souza MAd. Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. [Internet] [Doctoral dissertation]. Universidade Estadual de Campinas; 2009. [cited 2021 Apr 11]. Available from: SOUZA, Marcio Antonio de. Analgesia de parto: bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. 2009. 91 f. Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/309851>. Acesso em: 13 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/309851.

Council of Science Editors:

Souza MAd. Analgesia de parto : bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. [Doctoral Dissertation]. Universidade Estadual de Campinas; 2009. Available from: SOUZA, Marcio Antonio de. Analgesia de parto: bloqueio combinado raqui-peridural versus bloquei peridural continuo em primigestas. 2009. 91 f. Dissertação ( mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/309851>. Acesso em: 13 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/309851

Eastern Michigan University

13. Petzoldt-Hansell, Joy. Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia.

Degree: MS, Health Sciences, 2016, Eastern Michigan University

URL: https://commons.emich.edu/theses/861

► Cesarean delivery and epidural anesthesia may require specific education and interventions for breastfeeding success. The objective of this study was to examine the prevalence… (more)

Subjects/Keywords: Breastfeeding; Cesarean Delivery; education; Epidural Anesthesia; success; support; Medicine and Health Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petzoldt-Hansell, J. (2016). Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia. (Masters Thesis). Eastern Michigan University. Retrieved from https://commons.emich.edu/theses/861

Chicago Manual of Style (16^th Edition):

Petzoldt-Hansell, Joy. “Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia.” 2016. Masters Thesis, Eastern Michigan University. Accessed April 11, 2021. https://commons.emich.edu/theses/861.

MLA Handbook (7^th Edition):

Petzoldt-Hansell, Joy. “Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia.” 2016. Web. 11 Apr 2021.

Vancouver:

Petzoldt-Hansell J. Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia. [Internet] [Masters thesis]. Eastern Michigan University; 2016. [cited 2021 Apr 11]. Available from: https://commons.emich.edu/theses/861.

Council of Science Editors:

Petzoldt-Hansell J. Breastfeeding education and support needs for women after a cesarean delivery or epidural anesthesia. [Masters Thesis]. Eastern Michigan University; 2016. Available from: https://commons.emich.edu/theses/861

14. Tatiana Ferrante de Almeida. Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas.

Degree: 2003, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13092007-160517/

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Os opióides, como o fentanil e o sufentanil, embora amplamente utilizados em cães são raramente empregados pela via epidural nesta espécie. O presente estudo teve… (more)

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Os opióides, como o fentanil e o sufentanil, embora amplamente utilizados em cães são raramente empregados pela via epidural nesta espécie. O presente estudo teve como objetivo avaliar comparativamente os efeitos cardiovasculares e sistêmicos bem como a analgesia no período pós-operatório imediato e tardio da anestesia epidural realizada com fentanil ou sufentanil associados a bupivacaína ou desta sozinha em cadelas, sedados com infusão contínua de propofol. Para tanto foram utilizadas 30 fêmeas da espécie canina, submetidas a ovariosalpingohisterectomia eletiva, distribuídas aleatoriamente em 3 grupos de 10 animais cada. Todos os animais deste estudo receberam acepromazina (0,1 mg/kg), e infusão contínua de propofol para sedação. Os animais do grupo I foram então tratados com o fentanil (2 µg/kg) e bupivacaína (1,0 mg/kg), os do grupo II com sufentanil (1µg/kg) e bupivacaína (1,0 mg/kg), e os do grupo III com bupivacaína (1,0 mg/kg). Os agentes foram administrados pela via epidural, no espaço lombo-sacral, e diluídos em solução salina para um volume total de 0,36 ml/kg. A freqüência cardíaca, freqüência respiratória, e pressões arterial sistólica, média e diastólica foram mensuradas bem como pH e gases sangüíneos. Para avaliação de parâmetros sistêmicos relacionados á qualidade da analgesia no trans e pós-operatório foram analisados grau de analgesia e sedação e catecolaminas. A avaliação da extensão do bloqueio foi realizada através do teste do panículo. Para avaliação da latência e duração de ação motora e sensitiva dos fármacos foi realizado o pinçamento do espaço interdigital de membros pélvicos e da região perianal. O período total de avaliação foi de 6 horas após a realização da anestesia epidural. Não foram verificadas diferenças significativas quanto a alterações no sistema cardiovascular e respiratório, nem quanto a alterações na avaliação da sedação. Pode-se observar que o grupo tratado com bupivacaína e sufentanil obteve menores escores de dor no período pós-operatório, mas os demais grupos obtiveram valores satisfatórios em relação a este parâmetro. Pelos resultados obtidos, pode-se concluir que todos os protocolos permitiram a realização do procedimento cirúrgico, e produziram analgesia adequada, nos animais estudados, com modulação da resposta neuroendócrina à dor e mínimos efeitos adversos.

Potent opioids such as fentanyl and sufentanil, althought largely used in dogs, are rarely employed at the epidural space on this species. The aim of the present study was to compare the cardiovascular and systemics effects, as well as the analgesic action on the post operative period of epidural anaesthesia performed with bupivacaine alone or associated with fentanyl and sufentanil, in bitches sedated with continuous infusion of propofol. Thirty female dogs, submitted to ovariosalpingohisterectomy, allocated in three groups of ten animals each were used. All the animals received acepromazine (0,1 mg/kg), and continuous infusion of propofol for sedation. The animals of group I received…

Advisors/Committee Members: Denise Tabacchi Fantoni, Silvia Renata Gaido Cortopassi, Marcelo Luis Abramides Torres.

Subjects/Keywords: Anestesia epidural; Bupivacaína; Cães; Fentanil; Sufentanil; Bupivacaine; Dogs; Epidural anesthesia; Fentanyl; Sufentanil

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Almeida, T. F. d. (2003). Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13092007-160517/

Chicago Manual of Style (16^th Edition):

Almeida, Tatiana Ferrante de. “Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas.” 2003. Masters Thesis, University of São Paulo. Accessed April 11, 2021. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13092007-160517/.

MLA Handbook (7^th Edition):

Almeida, Tatiana Ferrante de. “Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas.” 2003. Web. 11 Apr 2021.

Vancouver:

Almeida TFd. Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas. [Internet] [Masters thesis]. University of São Paulo; 2003. [cited 2021 Apr 11]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13092007-160517/.

Council of Science Editors:

Almeida TFd. Uso da bupivacaína isolada e associada ao fentanil e sufentanil em anestesia epidural em cadelas. [Masters Thesis]. University of São Paulo; 2003. Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-13092007-160517/

15. Lutz, Kristin Felde. The association between physical and sexual abuse and use of intrapartum epidural anesthesia.

Degree: MS, 1996, Oregon Health Sciences University

URL: doi:10.6083/M4WH2N7T ; http://digitalcommons.ohsu.edu/etd/2702

Subjects/Keywords: Spouse Abuse; Rape; Anesthesia, Epidural; Delivery, Obstetric; Pregnancy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lutz, K. F. (1996). The association between physical and sexual abuse and use of intrapartum epidural anesthesia. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4WH2N7T ; http://digitalcommons.ohsu.edu/etd/2702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lutz, Kristin Felde. “The association between physical and sexual abuse and use of intrapartum epidural anesthesia.” 1996. Thesis, Oregon Health Sciences University. Accessed April 11, 2021. doi:10.6083/M4WH2N7T ; http://digitalcommons.ohsu.edu/etd/2702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lutz, Kristin Felde. “The association between physical and sexual abuse and use of intrapartum epidural anesthesia.” 1996. Web. 11 Apr 2021.

Vancouver:

Lutz KF. The association between physical and sexual abuse and use of intrapartum epidural anesthesia. [Internet] [Thesis]. Oregon Health Sciences University; 1996. [cited 2021 Apr 11]. Available from: doi:10.6083/M4WH2N7T ; http://digitalcommons.ohsu.edu/etd/2702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lutz KF. The association between physical and sexual abuse and use of intrapartum epidural anesthesia. [Thesis]. Oregon Health Sciences University; 1996. Available from: doi:10.6083/M4WH2N7T ; http://digitalcommons.ohsu.edu/etd/2702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vilnius University

16. Gasiūnaitė, Diana. Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos.

Degree: Dissertation, Medicine, 2013, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092326-27467 ;

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Disertacijoje analizuojama ir lyginama bendrosios endotrachėjinės ir kombinuotos endotrachėjinės epiduralinės anestezijos įtaka atskiroms organų sistemoms ir tas sistemas apibūdinantiems rodikliams laparoskopinių kolorektalinių operacijų metu. Darbe… (more)

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Disertacijoje analizuojama ir lyginama bendrosios endotrachėjinės ir kombinuotos endotrachėjinės epiduralinės anestezijos įtaka atskiroms organų sistemoms ir tas sistemas apibūdinantiems rodikliams laparoskopinių kolorektalinių operacijų metu. Darbe nagrinėjama dviejų perioperacinių skausmo malšinimo būdų įtaka hemodinamikos ir kvėpavimo sistemos parametrų kitimo tendencijoms, pacientų trachėjos ekstubacijos laikui, žarnyno motorikos atsinaujinimo greičiui, hospitalizacijos trukmei bei organizmo uždegiminiam atsakui. Laparoskopinės storosios žarnos rezekcinės operacijos, net ir būdamos minimaliai invazinės dėl laparoskopinės operacijos technikos, sužadina stresinį organizmo atsaką bei uždegimo mediatorių išskyrimą. Perioperacinis skausmo valdymas taip pat gali daryti įtaką imuniniam atsakui. Disertacijoje nagrinėjama epiduralinės analgezijos metodo įtaka organizmo stresiniam atsakui tiriant kortizolio kiekio kitimus ir interleukino-6, kaip vieno pagrindinių uždegimą skatinančių citokinų, koncentracijos kitimą taikant epiduralinę analgezijos metodiką. Gauti rezultatai parodė, kad analgezijai pasitelkiant epiduralinį skausmo malšinimo metodą, perioperacinis pacientų skausmo valdymas ir pasitenkinimas yra geresnis, trachėjos ekstubacijos laikas patikimai trumpesnis, žarnyno peristaltikos atsitaisymas ankstyvesnis, sukeliamas stresinis organizmo atsakas mažesnis (mažesnis kortizolio koncentracijos padidėjimas) ir nenustatyta komplikacijų padaugėjimo.

The doctoral dissertation analyses and compares general endotracheal and combined endotracheal epidural anesthesia’s impact on organ systems and describes the systems parameters in laparoscopic colorectal surgery. Comparing two perioperative analgesia techniques used in laparoscopic colorectal surgery the hemodynamic and respiratory parameters trends; the impact of anesthesia and postoperative analgesia methods on patients’ tracheal extubation time, intestinal motility recovery rate, duration of hospitalization and inflammatory response have been determined. Laparoscopic colorectal resection, even being a minimally invasive technique for laparoscopic surgery, stimulates the body's response to stress and pro-inflammatory mediator’s secretion. Perioperative pain management may also influence the immune response. The doctoral dissertation analyses the impact of epidural analgesia method on the body stress response, investigating variations of cortisol and interleukin-6 levels. The results showed that analgesia and patient satisfaction using epidural analgesia method for perioperative pain management were better. Tracheal extubation time was significantly shorter. Recovery of intestinal motility using epidural analgesia was significant and much prior than using intravenous analgesia. The use of epidural analgesia in laparoscopic colorectal surgery caused less stress response – less cortisol levels increase. It has not showed the increase in number of complications.

Advisors/Committee Members: STRUPAS, KĘSTUTIS (Doctoral dissertation committee chair), TUTKUVIENĖ, JANINA (Doctoral dissertation committee member), DIDŽIAPETRIENĖ, JANINA (Doctoral dissertation committee member), KINDURIS, ŠARŪNAS (Doctoral dissertation committee member), ŠIRVINSKAS, EDMUNDAS (Doctoral dissertation committee member), MACAS, ANDRIUS (Doctoral dissertation opponent), IVAŠKEVIČIUS, JUOZAS (Doctoral dissertation opponent).

Subjects/Keywords: Kolorektalinės operacijos; Epiduralinė analgezija; Kombinuota anestezija; Kortizolio kiekis; Stresinis atsakas; Colorectal surgery; Epidural analgesia; Combined anesthesia; Cortisol level; Stress response

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gasiūnaitė, D. (2013). Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092326-27467 ;

Chicago Manual of Style (16^th Edition):

Gasiūnaitė, Diana. “Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos.” 2013. Doctoral Dissertation, Vilnius University. Accessed April 11, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092326-27467 ;.

MLA Handbook (7^th Edition):

Gasiūnaitė, Diana. “Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos.” 2013. Web. 11 Apr 2021.

Vancouver:

Gasiūnaitė D. Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos. [Internet] [Doctoral dissertation]. Vilnius University; 2013. [cited 2021 Apr 11]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092326-27467 ;.

Council of Science Editors:

Gasiūnaitė D. Bendrosios ir kombinuotos anestezijos metodų palyginimas pacientams, kuriems atliekamos storosios žarnos laparoskopinės operacijos. [Doctoral Dissertation]. Vilnius University; 2013. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092326-27467 ;

Freie Universität Berlin

17. Enigk, Fabian Lukas. Effects of different therapeutic approaches on the endotoxin-injured intestine.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4338

► Introduction: With approximately 60,000 deaths per year sepsis is the third leading cause of death in Germany. Bacterial translocation due to the damage of intestinal… (more)

▼ Introduction: With approximately 60,000 deaths per year sepsis is the third leading cause of death in Germany. Bacterial translocation due to the damage of intestinal epithelial barrier represents an important factor for the development and maintenance of septic course. The sympathetic nervous system influences the endotoxin-induced activation of immunocompetent cells. Study I examined the effects of regional sympathetic blockade by thoracic epidural anesthesia (TEA) on the endotoxin-induced intestinal leukocyte-endothelial interaction and the consecutive endothelial injury. Study II investigated the impact of TEA on the endotoxin-induced increase in intestinal epithelial permeability. Study III quantified the effect of volume replacement during endotoxemia with either hydroxyethyl starch, gelatin, or isotonic saline on intestinal microcirculatory impairment. Methods: Male rats were anesthetized, cannulated and hemodynamically monitored. Endotoxemia was initiated following the particular study protocol. Animals of study I and II were additionally equipped with an epidural catheter for continuous application of lidocaine or isotonic saline. In study I catecholamine and cytokine concentration in plasma, adhesion molecule expression, leukocyte adhesion and intestinal tissue edema were determined. Study II investigated intestinal epithelial permeability, macrophage expression of inducible NO synthase and 8-isoprostane tissue concentration. Study III examined the effects of different volume replacement regimes on intestinal functional capillary density, velocity of erythrocytes and mesenteric leukocyte-endothelial interaction. Results: Study I: TEA reduced epinephrine plasma concentration by 32%. This was associated with a decrease in interleukin-1β plasma concentration (48%), a decrease in expression of endothelial adhesion molecules E-selectin (34%) and ICAM-1 (42%) and a decrease of intestinal tissue edema (75%). Study II: TEA reduced the endotoxin-induced increase in intestinal epithelial permeability by 30%. Expression of NO synthase and lipid peroxidation were lessened by 70% and 59% respectively. Study III: After fluid resuscitation with isotonic saline the functional capillary density was decreased by 18.5%. There were no detectable changes of functional capillary density in the hydroxyethyl starch or gelatin group. Regarding other test parameters significant differences could not be demonstrated. Discussion: Study I and II: The effect of TEA on the adhesion and extravasation of immune cells may be due to the reduction of plasma epinephrine concentration. Alternatively, a direct influence on the immune cells via nerve connections (nerve-immune interplay) or a systemic effect of lidocaine should be considered. Study III: Under comparable macrohemodynamic parameters and volume status the discrepancy in microcirculation seems to be due to effects like changes in red blood cell rigidity, endothelial swelling or the extent of surrounding tissue edema. An impact of colloidal solutions on the immune response to endotoxin… Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: epidural anesthesia; endotox anemia; endothelial damage; epithelium damage; microcirculation; intestine; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Enigk, F. L. (2015). Effects of different therapeutic approaches on the endotoxin-injured intestine. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Enigk, Fabian Lukas. “Effects of different therapeutic approaches on the endotoxin-injured intestine.” 2015. Thesis, Freie Universität Berlin. Accessed April 11, 2021. http://dx.doi.org/10.17169/refubium-4338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Enigk, Fabian Lukas. “Effects of different therapeutic approaches on the endotoxin-injured intestine.” 2015. Web. 11 Apr 2021.

Vancouver:

Enigk FL. Effects of different therapeutic approaches on the endotoxin-injured intestine. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Apr 11]. Available from: http://dx.doi.org/10.17169/refubium-4338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Enigk FL. Effects of different therapeutic approaches on the endotoxin-injured intestine. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-4338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

18. Blomberg, Sture, 1944-. Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease.

Degree: 1989, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/15745

Subjects/Keywords: Anestesi; Cirkulationsorgan Kardiologi Angiologi Anesthesia; epidural; Arrhythmia: physiopathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Blomberg, Sture, 1. (1989). Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/15745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Blomberg, Sture, 1944-. “Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease.” 1989. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 11, 2021. http://hdl.handle.net/2077/15745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Blomberg, Sture, 1944-. “Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease.” 1989. Web. 11 Apr 2021.

Vancouver:

Blomberg, Sture 1. Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1989. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2077/15745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Blomberg, Sture 1. Thoracic epidural anaesthesia and myocardial ischaemia : studies on experimental myocardial ischaemia and patients with coronary artery disease. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1989. Available from: http://hdl.handle.net/2077/15745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Korakianitis, Odysseas. Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία.

Degree: 2020, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ)

URL: http://hdl.handle.net/10442/hedi/47882

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Back-ground/Aims: There is much evidence that properly selected patients with peritoneal malignancy may be offered significant survival benefit undergoing cytoreduction in combination with hyperthermic intraperitoneal… (more)

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Back-ground/Aims: There is much evidence that properly selected patients with peritoneal malignancy may be offered significant survival benefit undergoing cytoreduction in combination with hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC). Cytoreductive surgery is associated with coagulopathy alterations. Epidural analgesia is effective in major surgery. The purpose of the study is the identification of the effect of coagulation during cytoreduction and HIPEC. Patients/Methods: Prospective observational study in patients with peritoneal malignancy that underwent cytoreduction and HIPEC. Epidural analgesia was offered to all patients. Peripheral venous samples in specific time points were tested for complete blood count, prothrombin time, activated partial thromboplastin time, international normalized ratio, fibrinogen, d-dimers, and expression of the GpIIb/IIIa platelet receptor, with simultaneous record of the patient’s hemodynamics. Results: From May 2011 until April 2012, 51 patients with peritoneal malignancy underwent cytoreductive surgery and HIPEC. The mean number of platelets, and fibrinogen levels decreased significantly while the mean number of d-dimers, aPTT, and INR increased singificantly. The total number of GpIIb/IIIa platelet receptors showed no significant variation. Despite significant variations all the examined parameters remained in levels permiting perioperative epidural analgesia. No relevant complications were recorded. Conclusions: Despite intraoperative variations in a few coagulation parameters, the results of the study support the belief that epidural analgesia is a safe option in patients undergoing major cytoreduction and HIPEC. The abnormalities of coagulation recorded during the operation should be definitely corrected.

Ιστορικό-Σκοπός: Υπάρχουν αρκετές ενδείξεις ότι αυστηρά επιλεγμένοι ασθενείς με περιτοναϊκή κακοήθεια, μπορεί να ωφεληθούν σημαντικά, εφόσον υποβληθούν σε εκτεταμένη κυτταρομείωση και περιεγχειρητική ενδοπεριτοναϊκή χημειοθεραπεία. Η κυτταρομειωτική χειρουργική συνοδεύεται από μεταβολές του πηκτικού μηχανισμού. Η επισκληρίδιος αναλγησία είναι μέθοδος, με εξαιρετικά αποτελέσματα σε μεγάλες χειρουργικές επεμβάσεις. Σκοπός της μελέτης είναι η διερεύνηση των επιπτώσεων των μεταβολών του πηκτικού μηχανισμού στην επισκληρίδιο αναλγησία, κατά τη διάρκεια κυτταρομειωτικής χειρουργικής και υπέρθερμης διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας. Ασθενείς-Μέθοδοι: Προοπτική μελέτη παρατήρησης σε ασθενείς με περιτοναϊκή κακοήθεια, οι οποίοι υποβλήθηκαν σε κυτταρομειωτική χειρουργική και περιεγχειρητική ενδοπεριτοναϊκή χημειοθεραπεία. Όλοι οι ασθενείς υποβλήθηκαν σε επισκληρίδιο καθετηριασμό. Σε καθορισμένα χρονικά διαστήματα λαμβάνονταν δείγματα περιφερικού αίματος, για γενική αίματος, χρόνο προθρομβίνης, χρόνο μερικής θρομβοπλαστίνης, INR, ινωδογόνο, D-dimers και έκφραση του υποδοχέος των αιμοπεταλίων GpIIb/IIIa, με σύγχρονη καταγραφή της αιμοδυναμικής καταστάσεως του ασθενούς. Αποτελέσματα: Από τον Μάϊο του 2011 έως τον Απρίλιο του 2012, 51 ασθενείς με…

Subjects/Keywords: Κυτταρομειωτική χειρουργική; Υπέρθεμη διεγχειρητική ενδοπεριτοναική χημειοθεραπεία; Πηκτικός μηχανισμός; Επισκληρίδιος αναισθησία; Cytoreductive surgery; HIPEC; Coagulation; Epidural anesthesia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Korakianitis, O. (2020). Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία. (Thesis). Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/47882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Korakianitis, Odysseas. “Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία.” 2020. Thesis, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Accessed April 11, 2021. http://hdl.handle.net/10442/hedi/47882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Korakianitis, Odysseas. “Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία.” 2020. Web. 11 Apr 2021.

Vancouver:

Korakianitis O. Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία. [Internet] [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 2020. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10442/hedi/47882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Korakianitis O. Οι επιπτώσεις της κυτταρομειωτικής χειρουργικής και της υπερθέρμου διεγχειρητικής ενδοπεριτοναϊκής χημειοθεραπείας στον πηκτικό μηχανισμό και στην επισκληρίδιο αναισθησία-αναλγησία. [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 2020. Available from: http://hdl.handle.net/10442/hedi/47882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Sellers, Austin. Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy.

Degree: MS, Medical Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/23993

► INTRODUCTION: The implementation of open posterior component separation (PCS) surgery has led to improved outcomes for complex hernias. While the PCS technique has been shown… (more)

▼ INTRODUCTION: The implementation of open posterior component separation (PCS) surgery has led to improved outcomes for complex hernias. While the PCS technique has been shown to decrease recurrence rates, and provide a feasible option to repair hernias in nontraditional locations, there is still significant postoperative pain associated with the laparotomy and extensive abdominal wall manipulation. Systemic opioids and thoracic epidural analgesia (TEA) are both commonly utilized, either together or independently, as postoperative analgesic regimens. The benefits of TEA have been studied following a variety of surgeries, however to date no study has been performed to investigate its efficacy in this particular surgery. The aim of this study is to evaluate the benefits of TEA following open PCS. We hypothesized that the incorporation of TEA in a patients postoperative analgesic regimen would show an advantage in time to bowel recovery. METHODS: An electronic medical record query was done to identify patients who had undergone an open PCS. Once this list was compiled, a retrospective chart review was performed and patients receiving TEA (either alone or combined with systemic opioids) were compared to patients receiving only systemic opioids. The primary endpoint compared time to resumption of a full diet, given by the patients postoperative day (POD). Secondarily, time to resumption of a liquid diet, postoperative length of stay (LOS), intensive care unit (ICU) admission rate, ICU LOS, and rates of several postoperative complications were all recorded and compared. A post-hoc analysis was also performed using the same endpoints. This analysis compared cohorts of patients receiving TEA and avoiding all systemic opioids, to patients who received systemic opioids (whether alone or combined with TEA). RESULTS: Based on inclusion parameters, 101 patients met criteria for analysis. In the initial analysis, 62 patients received TEA with or without systemic opioids, and 39 patients received only systemic opioids. In comparing these groups, there was no statistically significant difference in time to full diet (TEA 2.6 ± 1.7 vs Systemic opioids 3.1 ± 2.1 [mean POD ± SD]; P=0.21). In addition, no differences were found in the secondary outcomes of time to liquid diet, ICU admission, ICU LOS, or postoperative complications. In the post-hoc analysis, the 37 patients that received only TEA, were compared against 64 patients that received systemic opioids (either with or without TEA). In this comparison, the group receiving only TEA was found to have a statically shorter time to bowel recovery compared to patients receiving systemic opioids (TEA alone 2.2 ± 1.0 vs Systemic opioids 3.2 ± 2.2, P=0.0033). This subgroup (TEA only) also showed statically shorter time to liquid diet and a decreased postoperative LOS. CONCLUSION: For patients undergoing an open PCS, the inclusion of TEA in the postoperative analgesic regimen did not shorten return of bowel function. However, when TEA was utilized and systemic opioids were avoided,…

Subjects/Keywords: Medicine; Posterior component separation; Thoracic epidural anesthesia

…LIST OF TABLES Table 1 Title Demographics for primary analysis (thoracic epidural… …for primary analysis (thoracic epidural, with 11 and without systemic opioids, versus… …systemic opioids alone) 3 Demographics for post-hoc analysis (thoracic epidural 13… …alone versus systemic opioids, with or without thoracic epidural) 4 Epidural Local… …epidural alone 15 versus systemic opioids, with or without thoracic epidural) vii LIST…

1 more image…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sellers, A. (2017). Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/23993

Chicago Manual of Style (16^th Edition):

Sellers, Austin. “Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy.” 2017. Masters Thesis, Boston University. Accessed April 11, 2021. http://hdl.handle.net/2144/23993.

MLA Handbook (7^th Edition):

Sellers, Austin. “Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy.” 2017. Web. 11 Apr 2021.

Vancouver:

Sellers A. Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2144/23993.

Council of Science Editors:

Sellers A. Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23993

Georgia Tech

21. Tian, Haozheng. Public Health Informatics - Strategy and Decision Modeling.

Degree: PhD, Biology, 2019, Georgia Tech

URL: http://hdl.handle.net/1853/64016

► My research is composed of three studies focused on providing decision modeling and analytical tools with the objective of protecting public health. The first study… (more)

▼ My research is composed of three studies focused on providing decision modeling and analytical tools with the objective of protecting public health. The first study introduces an agent-based simulation platform that serves as a decision support system for crowd management in public venues. I propose a new implementation of agent-based simulation with improvement on four aspects: path planning, collision avoidance, emotion modeling and optimization with simulation. The deliverables of this study also include a complete simulation platform for researcher’s use. The second study applies a data-driven informatics and machine learning approach to quantify the outcome of practice variance of medical care providers. The study investigates the safety and efficacy of a large-dose, needle-based epidural anesthesia technique for parturient women. Machine learning model is proposed as the classifier to predict the occurrence of hypotension. Further, machine learning approach is applied to predict the outcome of epidural anesthesia, uncovering the important factors of a successful practice. Quantification of the effect of practice variance and medicine usage is provided. The findings from this investigation facilitate delivery improvement and establish an improved clinical practice guideline for training and for dissemination of safe practice. The third study proposes the application of convolutional neural network (CNN) in the prediction of antigenicity of influenza viruses (A/H3N2) and vaccine recommendation. The study systematically explores the ways of representation of hemagglutinin (HA) besides using binary digit or character as widely applied in other researches. Heuristic optimization is applied to optimize the selection of AAindex as well as the structure of CNN. Contrasting to other state-of-the-art approaches, the model offers better coverage in vaccine recommendation and has superior performance in accurate prediction of antigenicity. Advisors/Committee Members: Jordan, I. King (advisor).

Subjects/Keywords: agent-based simulation; agent-based modeling; flood theta* algorithm; epidural anesthesia; clinical practice guidelines; convolutional neural network; hemagglutinin; hemagglutinin inhibition; multi-dimensional scaling; influenza A; H3N2; needle-based epidural approach; catheter-based epidural approach; particle swarm optimization

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APA (6^th Edition):

Tian, H. (2019). Public Health Informatics - Strategy and Decision Modeling. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/64016

Chicago Manual of Style (16^th Edition):

Tian, Haozheng. “Public Health Informatics - Strategy and Decision Modeling.” 2019. Doctoral Dissertation, Georgia Tech. Accessed April 11, 2021. http://hdl.handle.net/1853/64016.

MLA Handbook (7^th Edition):

Tian, Haozheng. “Public Health Informatics - Strategy and Decision Modeling.” 2019. Web. 11 Apr 2021.

Vancouver:

Tian H. Public Health Informatics - Strategy and Decision Modeling. [Internet] [Doctoral dissertation]. Georgia Tech; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1853/64016.

Council of Science Editors:

Tian H. Public Health Informatics - Strategy and Decision Modeling. [Doctoral Dissertation]. Georgia Tech; 2019. Available from: http://hdl.handle.net/1853/64016

22. Διαμαντής, Μόρφης. Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή.

Degree: 2012, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/29614

► Introduction: Nowadays, regional anaesthesia has replaced general anaesthesia forelective caesarean sections. The aim of this randomized study was to compare thecombined subarachnoid-epidural technique with the… (more)

▼ Introduction: Nowadays, regional anaesthesia has replaced general anaesthesia forelective caesarean sections. The aim of this randomized study was to compare thecombined subarachnoid-epidural technique with the epidural technique.Materials and methods: One hundred and eight parturients scheduled for electivecaesarean section were randomly chosen to receive combined subarachnoid-epiduralanaesthesia (n = 54) or epidural anaesthesia (n = 54). Through the epidural catheter, 15ml of ropivacaine 0.75% in increments was given to the epidural group, whereas thecombined group received 2 ml of ropivacaine 0.75%. After the operation, the methods ofchoice for analgesia were the systematic epidural administration of 0.2% ropivacaine andthe application of a PCA pump with morphine.Time required for the sensory block to reach T10, Σ7 and T4 dermatomes, thelevel of motor block when sensory block was at T7 dermatome, the supplementary dosesand the rescue doses of ropivacaine needed intraoperatively were recorded, as well as theincision time and the duration of surgery, the time of entrance and discharge from thePACU, and the duration of PACU stay. Regression of the block below T4 dermatome andup to T6 dermatome, were registered. Finally, the time of full recovery of motor blockwas recorded, as well as the level of the sensory block at that moment.Two, 4, 8 and 24 hours after the operation, the analgesic requirements formorphine, as well as the VAS scores at rest and cough were recorded. Ambulation ability8 hours after the operation, satisfaction using the verbal score scale 0-10, as well as theincidence of headache, nausea and vomiting, in the first 24 hours postoperatively wererecorded.Results: Time required for the sensory block to reach T7 and T10 was 13.1 ± 3.8 minand 17.79 ± 5.35 min for epidural anaesthesia and 5 ± 2.7 min and 6.5 ± 2.3 min forcombined anaesthesia respectively (p< 0.001). Sensory block reached T4 dermatomeafter 28 ± 10 min in the epidural group and after 9 ± 4 min in the combined group (p<0.001) and regressed to T6 dermatome after 200 (98-439) min in the epidural group and125.5 (70-332) min in the combined group (p< 0.001). At the time sensory block was atT7, there was a better motor response in the epidural group compared to the combinedgroup. Eleven out of 53 parturients needed supplementary dose from the epidural group,102whereas no parturient needed supplementary dose in the combined group (p< 0.001).There was no significant difference in the number of parturients requiring rescue dosebetween the two groups (p= 0.72). The incision time was significantly higher in theepidural (34.81 ± 9.05) than in the combined anaesthesia group (16.77 ± 4.2) (p< 0.001).The duration of surgery was significantly higher in the epidural (84.88 ± 14.42 min) thanin the combined group (68.48 ± 14.2 min) (p< 0.001). In addition, there was a significantdifference in time of entrance and exit from the PACU between the epidural group (93.14± 14.9 and 233.3 ± 86.02 min, respectively) and the combined group (76.23 ± 14.2 and154.65 ± 61.8…

Subjects/Keywords: Επισκληρίδιος αναισθησία; Συνδυασμένη υπαραχνοειδής - επισκληρίδια αναισθησία; Καισαρική τομή; Ταχεία διακίνηση; Ροπιβακαΐνη; Μετεγχειρητικός πόνος; Κατανάλωση μορφίνης; Ικανοποίηση ασθενών; Epidural anesthesia; Combined spinal epidural anesthesia; Cesarean section; Fast tracking; Ropivacaine; Postoperative pain; Morphine consuption; Patient satisfaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Διαμαντής, . �. (2012). Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/29614

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Διαμαντής, Μόρφης. “Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή.” 2012. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 11, 2021. http://hdl.handle.net/10442/hedi/29614.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Διαμαντής, Μόρφης. “Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή.” 2012. Web. 11 Apr 2021.

Vancouver:

Διαμαντής �. Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10442/hedi/29614.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Διαμαντής �. Περιοχική αναισθησία ταχείας διακίνησης στην καισαρική τομή. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2012. Available from: http://hdl.handle.net/10442/hedi/29614

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Stelflug, Bradley. Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients.

Degree: DAP, Doctor of Nurse Anesthesia, 2018, University of Michigan

URL: http://hdl.handle.net/2027.42/143509

► Purpose: The purpose of this project was to develop clear guidelines and increase safety for the preeclamptic parturients receiving labor epidurals and to protect their… (more)

▼ Purpose: The purpose of this project was to develop clear guidelines and increase safety for the preeclamptic parturients receiving labor epidurals and to protect their infants. Recommendations were elicited from seasoned practitioners of obstetrical (OB) anesthesia to establish parameters to guide fluid management decisions, recommend a specific volume range and type of fluid to be given, and recommend how best to treat hypotension caused by sympathectomy. Methods: A cross-sectional survey design was used. Certified Registered Nurse Anesthetists from Michigan and Indiana who regularly provide OB anesthesia were asked multiple choice and open-ended questions via an online survey (Qualtrics) to elicit recommendations on caring for preeclamptic and severely preeclamptic parturients receiving a labor epidural. Results: Nearly half (49.25%) of respondents recommended administering an IV fluid bolus prior to labor epidural placement in preeclamptic parturients. Another 44.78% listed factors such as blood pressure, fluid status, physical status or current symptoms, and renal function, as factors they consider before deciding on an IV fluid bolus. Both groups recommended administering an IV fluid bolus of 462 ml to 604 ml of a crystalloid solution. Twenty-six percent recommended treating hypotension in the preeclamptic parturient if mother or the fetus is symptomatic. Given a choice of multiple treatment options, over 75% of the experts recommended administering crystalloid, ephedrine, or phenylephrine to correct hypotension. Conclusions: CRNAs experts in the field of high-risk OB responded overwhelmingly positively to pretreating a preeclamptic parturient with an IV fluid bolus prior to administering a labor epidural. Anesthesia providers should feel confident administering a modest IV fluid bolus to mitigate hypotension caused by vasodilation from a labor epidural. Keywords: preeclampsia, labor epidural, fluid bolus, preload, hypotension Advisors/Committee Members: Fryzel, Shawn (advisor), Motz, Jane (committee member).

Subjects/Keywords: fluid bolus; hypotension; labor epidural; preeclampsia; preload; Anesthesia; Obstretrics; Nursing

…describe epidural anesthesia for laboring mothers.41 Dr. Eugen Bogdan Aburel introduced the… …epidural catheter for labor anesthesia in 1931.41 These early obstetric epidurals were placed… …subjects in the referenced RCTs were healthy and received spinal anesthesia, not epidural… …hypotension caused by epidural vasodilation.57 Anesthesia providers are given conflicting… …highrisk OB anesthesia. They all recommend giving an IV fluid bolus prior to labor epidural…

3 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stelflug, B. (2018). Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients. (Thesis). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/143509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stelflug, Bradley. “Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients.” 2018. Thesis, University of Michigan. Accessed April 11, 2021. http://hdl.handle.net/2027.42/143509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stelflug, Bradley. “Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients.” 2018. Web. 11 Apr 2021.

Vancouver:

Stelflug B. Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients. [Internet] [Thesis]. University of Michigan; 2018. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2027.42/143509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stelflug B. Intravenous Fluid Bolus Prior to Initiation of Epidural Analgesia in Preeclamptic Patients. [Thesis]. University of Michigan; 2018. Available from: http://hdl.handle.net/2027.42/143509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vilnius University

24. Gasiūnaitė, Diana. Comparison of general and combined anesthesia during laparoscopic colorectal surgery.

Degree: PhD, Medicine, 2013, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092313-13566 ;

►

The doctoral dissertation analyses and compares general endotracheal and combined endotracheal epidural anesthesia’s impact on organ systems and describes the systems parameters in laparoscopic colorectal… (more)

▼

The doctoral dissertation analyses and compares general endotracheal and combined endotracheal epidural anesthesia’s impact on organ systems and describes the systems parameters in laparoscopic colorectal surgery. Comparing two perioperative analgesia techniques used in laparoscopic colorectal surgery the hemodynamic and respiratory parameters trends; the impact of anesthesia and postoperative analgesia methods on patients’ tracheal extubation time, intestinal motility recovery rate, duration of hospitalization and inflammatory response have been determined. Laparoscopic colorectal resection, even being a minimally invasive technique for laparoscopic surgery, stimulates the body's response to stress and pro-inflammatory mediator’s secretion. Perioperative pain management may also influence the immune response. The doctoral dissertation analyses the impact of epidural analgesia method on the body stress response, investigating variations of cortisol and interleukin-6 levels. The results showed that analgesia and patient satisfaction using epidural analgesia method for perioperative pain management were better. Tracheal extubation time was significantly shorter. Recovery of intestinal motility using epidural analgesia was significant and much prior than using intravenous analgesia. The use of epidural analgesia in laparoscopic colorectal surgery caused less stress response – less cortisol levels increase. It has not showed the increase in number of complications.

Disertacijoje analizuojama ir lyginama bendrosios endotrachėjinės ir kombinuotos endotrachėjinės epiduralinės anestezijos įtaka atskiroms organų sistemoms ir tas sistemas apibūdinantiems rodikliams laparoskopinių kolorektalinių operacijų metu. Darbe nagrinėjama dviejų perioperacinių skausmo malšinimo būdų įtaka hemodinamikos ir kvėpavimo sistemos parametrų kitimo tendencijoms, pacientų trachėjos ekstubacijos laikui, žarnyno motorikos atsinaujinimo greičiui, hospitalizacijos trukmei bei organizmo uždegiminiam atsakui. Laparoskopinės storosios žarnos rezekcinės operacijos, net ir būdamos minimaliai invazinės dėl laparoskopinės operacijos technikos, sužadina stresinį organizmo atsaką bei uždegimo mediatorių išskyrimą. Perioperacinis skausmo valdymas taip pat gali daryti įtaką imuniniam atsakui. Disertacijoje nagrinėjama epiduralinės analgezijos metodo įtaka organizmo stresiniam atsakui tiriant kortizolio kiekio kitimus ir interleukino-6, kaip vieno pagrindinių uždegimą skatinančių citokinų, koncentracijos kitimą taikant epiduralinę analgezijos metodiką. Gauti rezultatai parodė, kad analgezijai pasitelkiant epiduralinį skausmo malšinimo metodą, perioperacinis pacientų skausmo valdymas ir pasitenkinimas yra geresnis, trachėjos ekstubacijos laikas patikimai trumpesnis, žarnyno peristaltikos atsitaisymas ankstyvesnis, sukeliamas stresinis organizmo atsakas mažesnis (mažesnis kortizolio koncentracijos padidėjimas) ir nenustatyta komplikacijų padaugėjimo.

Advisors/Committee Members: STRUPAS, KĘSTUTIS (Doctoral dissertation committee chair), TUTKUVIENĖ, JANINA (Doctoral dissertation committee member), DIDŽIAPETRIENĖ, JANINA (Doctoral dissertation committee member), KINDURIS, ŠARŪNAS (Doctoral dissertation committee member), ŠIRVINSKAS, EDMUNDAS (Doctoral dissertation committee member), MACAS, ANDRIUS (Doctoral dissertation opponent), IVAŠKEVIČIUS, JUOZAS (Doctoral dissertation opponent).

Subjects/Keywords: Laparoscopic colorectal surgery; Epidural analgesia; Combined anesthesia; Cortisol level; Stress response; Laparoskopinė kolorektalinė chirurgija; Epiduralinė analgezija; Kombinuota anestezija; Kortizolio kiekis; Stresinis atsakas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gasiūnaitė, D. (2013). Comparison of general and combined anesthesia during laparoscopic colorectal surgery. (Doctoral Dissertation). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092313-13566 ;

Chicago Manual of Style (16^th Edition):

Gasiūnaitė, Diana. “Comparison of general and combined anesthesia during laparoscopic colorectal surgery.” 2013. Doctoral Dissertation, Vilnius University. Accessed April 11, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092313-13566 ;.

MLA Handbook (7^th Edition):

Gasiūnaitė, Diana. “Comparison of general and combined anesthesia during laparoscopic colorectal surgery.” 2013. Web. 11 Apr 2021.

Vancouver:

Gasiūnaitė D. Comparison of general and combined anesthesia during laparoscopic colorectal surgery. [Internet] [Doctoral dissertation]. Vilnius University; 2013. [cited 2021 Apr 11]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092313-13566 ;.

Council of Science Editors:

Gasiūnaitė D. Comparison of general and combined anesthesia during laparoscopic colorectal surgery. [Doctoral Dissertation]. Vilnius University; 2013. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130930_092313-13566 ;

Freie Universität Berlin

25. Lenze, Jan. Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11329

► Intraoperative stress may induce suppression of the adaptive immune system. Major abdominal surgery reduces the functionality of Th1 cells, which is indicated by a reduction… (more)

▼ Intraoperative stress may induce suppression of the adaptive immune system. Major abdominal surgery reduces the functionality of Th1 cells, which is indicated by a reduction of proliferation capacity and an impairment of interferon-gamma (IFN-gamma) synthesis following an increase of cortisol, adrenalin and interleukin-10 (IL-10). The attenuated Th1 cell function can be assumed as the main mechanism of final degradation of the immune function in surgical patients. In this regard Th1 cell influence on antigen presenting cells (APC) may be of central importance. Activity of APC phagocytosis and following presentation of antigen via MHC-II is eminent stimulated by Th1 cells. A pathogen detection as a basement of reaction in the immunological recognition phase and the final and adequate elimination for example through synthesis of specific antibodies and following neutrophil granulocyte phagocytosis is highly influenced by Th1 cells. The study at hand hypothesized that reduction of stress response by use of intraoperative thoracic epidural anesthesia causes a preservation of Th1 specific immunological capacity. Preoperative 54 patients with upcoming major abdominal surgery were supplied with a thoracic epidural catheter. The patients were divided into two study groups. In the group of combined anesthesia intraoperative analgesia was performed by using a thoracic epidural catheter exclusively. In the control group intraoperative analgesia was based on systemic administration of opioid. In both groups patient controlled postoperative pain management was arranged by epidural anesthesia. Blood samples were drawn at baseline, 2 hours after beginning of surgery and at day 1 and day 4 after surgery. These blood samples were used to analyze the absolute number of helper T-cells, plasma concentration of IL-10 and IFN-gamma and the IL-10 and IFN-gamma concentration after concanavalin A (ConA) stimulation. Also at baseline and 40 minutes after surgery has been started blood samples were drawn to analyze plasma concentration of adrenalin and cortisol. Additionally depth of anesthesia was managed by bispectral index (BIS). Additive post- and intraoperative data for example postoperative infection rate were documented. The examined study groups did not differ significant in epidemiologic patient data and type and duration of surgery. Also no significant differences between depth of anesthesia, end-expiratory Isofluran concentration and intraoperative heart rate were detected. In the group of combined anesthesia a significant attenuated increase of adrenalin- and cortisol- plasma concentration, a significant reduced decrease of absolute T-Helper cell number at postoperative day 1, a significant reduced decrease of IFN-gamma/IL-10 ratio in plasma and a decreased reduction of IFN-gamma by stimulation with concanavalin A were observed. In the postoperative clinical course no significant differences between the study groups were detected. Overall intraoperative epidural anesthesia reduces the intraoperative stress represented by a… Advisors/Committee Members: m (gender), Priv.-Doz. Dr. med. D. Keh (firstReferee), Priv.-Doz. Dr. V. von Dossow-Hanfstingl (furtherReferee), Prof. Dr. M. Weiss (furtherReferee).

Subjects/Keywords: interferon-gamma; IL-10; Th1 cells; epidural anesthesia; cortisol; surgery; stress; adaptive immunity; immunosuppression; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lenze, J. (2011). Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lenze, Jan. “Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery.” 2011. Thesis, Freie Universität Berlin. Accessed April 11, 2021. http://dx.doi.org/10.17169/refubium-11329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lenze, Jan. “Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery.” 2011. Web. 11 Apr 2021.

Vancouver:

Lenze J. Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 11]. Available from: http://dx.doi.org/10.17169/refubium-11329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lenze J. Influence of intraoperative thoracic epidural anesthesia on stress response and inflammatory capacity of T-helper cells in patients undergoing major abdominal surgery. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-11329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. YU SHUANG. AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING.

Degree: 2015, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/121980

Subjects/Keywords: Image Processing; Epidural Anesthesia; Lumbar Ultrasound; Machine Learning; Support Vector Machine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SHUANG, Y. (2015). AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/121980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SHUANG, YU. “AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING.” 2015. Thesis, National University of Singapore. Accessed April 11, 2021. http://scholarbank.nus.edu.sg/handle/10635/121980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SHUANG, YU. “AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING.” 2015. Web. 11 Apr 2021.

Vancouver:

SHUANG Y. AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING. [Internet] [Thesis]. National University of Singapore; 2015. [cited 2021 Apr 11]. Available from: http://scholarbank.nus.edu.sg/handle/10635/121980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SHUANG Y. AUTOMATIC LOCALIZATION OF EPIDURAL NEEDLE ENTRY SITE WITH LUMBAR ULTRASOUND IMAGE PROCESSING. [Thesis]. National University of Singapore; 2015. Available from: http://scholarbank.nus.edu.sg/handle/10635/121980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. MOHAMMAD IKHSAN. TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES.

Degree: 2017, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/141265

Subjects/Keywords: image processing; machine learning; ultrasound-guided intervention; epidural anesthesia; central venous catheter placement

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APA (6^th Edition):

IKHSAN, M. (2017). TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/141265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

IKHSAN, MOHAMMAD. “TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES.” 2017. Thesis, National University of Singapore. Accessed April 11, 2021. http://scholarbank.nus.edu.sg/handle/10635/141265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

IKHSAN, MOHAMMAD. “TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES.” 2017. Web. 11 Apr 2021.

Vancouver:

IKHSAN M. TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES. [Internet] [Thesis]. National University of Singapore; 2017. [cited 2021 Apr 11]. Available from: http://scholarbank.nus.edu.sg/handle/10635/141265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

IKHSAN M. TOWARDS AUTOMATIC NEEDLE INSERTION POINT SELECTION FOR ULTRASOUND-GUIDED PERCUTANEOUS PROCEDURES. [Thesis]. National University of Singapore; 2017. Available from: http://scholarbank.nus.edu.sg/handle/10635/141265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Maryland

28. Tang, Qinggong Tang. Novel Endoscope for Surgical Guidance and Functional Brain Imaging.

Degree: Bioengineering, 2017, University of Maryland

URL: http://hdl.handle.net/1903/19759

► Optical imaging methods have become very powerful tools in biomedical research since they can achieve both high spatial and temporal resolutions. However, due to the… (more)

Subjects/Keywords: Biomedical engineering; epidural anesthesia; functional brain imaging; Gradient refractive index (GRIN) lens; optical coherence tomography (OCT); voltage-sensitive dye imaging (VSDi); whisker system of rodents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tang, Q. T. (2017). Novel Endoscope for Surgical Guidance and Functional Brain Imaging. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/19759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tang, Qinggong Tang. “Novel Endoscope for Surgical Guidance and Functional Brain Imaging.” 2017. Thesis, University of Maryland. Accessed April 11, 2021. http://hdl.handle.net/1903/19759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tang, Qinggong Tang. “Novel Endoscope for Surgical Guidance and Functional Brain Imaging.” 2017. Web. 11 Apr 2021.

Vancouver:

Tang QT. Novel Endoscope for Surgical Guidance and Functional Brain Imaging. [Internet] [Thesis]. University of Maryland; 2017. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1903/19759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tang QT. Novel Endoscope for Surgical Guidance and Functional Brain Imaging. [Thesis]. University of Maryland; 2017. Available from: http://hdl.handle.net/1903/19759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Isaac Azevedo Silva. Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental.

Degree: 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5156/tde-08082013-154929/

► INTRODUÇÃO: Atualmente, a maior limitação ao transplante cardíaco, em todo o mundo, é a escassez de doadores cujo número está sempre aquém do número de… (more)

▼ INTRODUÇÃO: Atualmente, a maior limitação ao transplante cardíaco, em todo o mundo, é a escassez de doadores cujo número está sempre aquém do número de pacientes portadores de doença cardíaca terminal, e esse hiato fica ainda maior pelo fato de cerca de 25 % dos corações doados não serem utilizados, por estarem acometidos por acentuada disfunção. A descarga catecolaminérgica associada à morte encefálica poderia ser um dos elementos implicados nesta disfunção. Assim, intervenções terapêuticas com intuito de minimizar o exacerbado estímulo simpático visam, em última instância, ampliar a oferta de órgãos para o transplante. OBJETIVOS: Investigar a hipótese de que a anestesia peridural torácica seja capaz de bloquear a tempestade autonômica inerente à morte encefálica por hipertensão intracraniana aguda, minimizando as alterações hemodinâmicas, reduzindo a resposta inflamatória e, por conseguinte, melhorando a condição do enxerto. MÉTODOS: Ratos Wistar machos (250-350 g) anestesiados (isoflurano 5 %) e monitorados continuamente para o registro da pressão arterial média foram submetidos à inserção de cateter no espaço peridural em nível torácico e, em seguida, submetidos à morte encefálica por hipertensão intracraniana aguda pela xxi insuflação de um cateter de Fogarty® introduzido por trepanação. Os animais (n = 28) foram alocados em 4 grupos: grupo salina - infusão de 20 uL de solução salina pelo cateter peridural antes da indução da morte encefálica; grupo bupi-pré - infusão de 20 uL de solução de bupivacaína a 0,5 % pelo cateter peridural, antes da indução da morte encefálica; grupo bupi-20 - infusão de 20 uL de solução de bupivacaína a 0,5 % pelo cateter peridural 20 minutos após a indução da morte encefálica; grupo bupi-60 - infusão de 20 ?L de solução de bupivacaína a 0,5 % pelo cateter peridural 60 minutos após a indução da morte encefálica. Após 6 horas os animais foram submetidos à eutanásia por exsanguinação. Foram realizadas dosagens séricas e no tecido cardíaco das citocinas interleucina (IL)-1beta e fator de necrose tumoral (TNF)-alfa pelo método de ELISA. As moléculas de adesão endoteliais, vascular adhesion molecule (VCAM)-1 e intercellular adhesion molecule (ICAM)-1, proteínas envolvidas no processo de apoptose, Bcl-2 e caspase-3, e a alfa-actina foram avaliadas no tecido miocárdico por técnica imunohistoquímica. Cortes longitudinais do coração foram corados com hematoxilina/eosina e avaliados quanto à presença de edema, infiltrado leucocitário e congestão vascular. Contagens totais de leucócitos circulantes foram realizadas antes da indução da morte encefálica e 3 e 6 horas após. RESULTADOS: Logo após a insuflação do cateter de Fogarty® todos animais evoluíram com sinais clínicos de morte encefálica: midríase bilateral fixa e ausência de reflexo corneano. O aumento súbito e efêmero da pressão arterial foi observado em todos os animais, à exceção do grupo que recebeu a bupivacaína previamente à indução da morte encefálica (grupo bupi-pré) (p<0,05). Houve acentuada e progressiva leucopenia em todos os… Advisors/Committee Members: Luiz Felipe Pinho Moreira, Walter José Gomes, Noedir Antonio Groppo Stolf.

Subjects/Keywords: Anestesia peridural; Bloqueio nervoso autônomo; Miocardite/fisiopatologia; Morte encefálica; Ratos Wistar; Sistema nervoso autônomo; Autonomic nerve block; Autonomic nervous system; Brain death; Epidural anesthesia; Myocarditis/physiopathology; Rats Wistar

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, I. A. (2013). Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5156/tde-08082013-154929/

Chicago Manual of Style (16^th Edition):

Silva, Isaac Azevedo. “Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental.” 2013. Doctoral Dissertation, University of São Paulo. Accessed April 11, 2021. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-08082013-154929/.

MLA Handbook (7^th Edition):

Silva, Isaac Azevedo. “Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental.” 2013. Web. 11 Apr 2021.

Vancouver:

Silva IA. Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Apr 11]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5156/tde-08082013-154929/.

Council of Science Editors:

Silva IA. Avaliação dos efeitos da anestesia peridural torácica sobre as alterações miocárdicas associadas à morte encefálica: estudo experimental. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5156/tde-08082013-154929/

30. Herrera Becerra, José Ricardo. Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total.

Degree: 2018, Brazil

URL: http://hdl.handle.net/10183/180530

►

Este estudo teve por objetivo investigar os efeitos analgésicos trans e pós-operatórios da administração epidural da ropivacaína associada à morfina e/ou xilazina em cadelas submetidas… (more)

▼

Este estudo teve por objetivo investigar os efeitos analgésicos trans e pós-operatórios da administração epidural da ropivacaína associada à morfina e/ou xilazina em cadelas submetidas a mastectomia unilateral total. Poucos são os relatos na literatura sobre uso de epidural mastectomia radical. Foram utilizadas 23 cadelas, pre-medicadas com acepromazina (0,02 mg/kg IM) e morfina (0,3 mg/kg IM) , e anestesiadas com propofol e posteriormente isofluorano associado à anestesia epidural com um dos três tratamentos: grupo RM (n=7), ropivacaína com morfina (0,75 e 0,1 mg/kg respectivamente); grupo RX (n=8), ropivacaína com xilazina (0,75 e 0,1 mg/kg respectivamente); e grupo RMX (n=7), ropivacaína associada à morfina e xilazina nas mesmas doses. O volume padronizado final dos tratamentos epidurais foi de 0,35 mL/kg ao serem diluídos com solução salina. Foram avaliados parâmetros cardiovasculares e respiratórios em seis momentos: Basal (durante a anestesia inalatória, antes da anestesia epidural), pós-epidural (30 minutos após tratamento epidural), T1, T2 e T3 (durante incisão da pele e divulsão do tecido dos terços caudal, médio e cranial da cadeia mamária, respectivamente) e T4 (rafia). Os escores de dor (escalas de Glasgow e EAVID) e necessidade de resgates analgésicos no pós-operatório foram avaliados durante 24 horas Houve menor requerimento de isofluorano nos animais dos grupos RX (1,1±0,2% em T3 e T4) e RMX (0,9 a 1,0±0,2% em T2, T3 e T4) versus o RM (1,3±0,2%). Nos grupos RX e RMX, houve diminuição da frequência cardíaca (RX no pós-epidural e em RMX no pós-epidural e T3) quando comparada com o basal mas não houve variações das pressões arteriais intra-grupo nem entre os grupos. O resgate pós-operatório foi necessário em 85,7%, 14,3% e 25,0% dos animais dos grupos RX, RM e RMX respectivamente. Os escores de dor foram menores nas primeiras quatro horas de pós-operatório no grupo RMX versus RX. Os animais do grupo RX demoraram mais para se manter em posição quadrupedal que o grupo RM (335 ± 82 versus 113 ± 69 minutos respectivamente) e teve maiores tempos de bloqueio motor (299 ± 90 versus 195 ± 37 minutos respectivamente). Quando administrados por via epidural, os três tratamentos fornecem analgesia trans-operatória aceitável para cadelas submetidas à mastectomia unilateral total, com mínimos efeitos cardiovasculares. A analgesia pós-operatória é mais prolongada nos protocolos de anestesia que têm morfina na sua composição (RM e RMX). Os protocolos com xilazina podem reduzir o requerimento de isofluorano, mas podem retardar o tempo de deambulação das cadelas.

This study aimed to investigate the intra and postoperative analgesic effects of epidural administration of ropivacaine combined with morphine and/or xylazine in bitches undergoing total unilateral mastectomy. There are few reports in the literature on the use of epidural in radical mastectomy. Twenty-three bitches were pre-medicated with acepromazine (0.02 mg/kg IM) and morphine (0.3 mg/kg IM) and anesthetized with propofol and isoflurane associated with…

Advisors/Committee Members: Monteiro, Eduardo Raposo.

Subjects/Keywords: Anestesia epidural; Mastectomia; Cães; Analgésicos; Xilazina; Morfina; Ropivacaína; Período pós-operatório; Periodo intra-operatorio; Locoregional anesthesia; Pain; Dogs; Analgesia; Oncology; Peridural; Neuroaxis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herrera Becerra, J. R. (2018). Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/10183/180530

Chicago Manual of Style (16^th Edition):

Herrera Becerra, José Ricardo. “Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total.” 2018. Masters Thesis, Brazil. Accessed April 11, 2021. http://hdl.handle.net/10183/180530.

MLA Handbook (7^th Edition):

Herrera Becerra, José Ricardo. “Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total.” 2018. Web. 11 Apr 2021.

Vancouver:

Herrera Becerra JR. Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total. [Internet] [Masters thesis]. Brazil; 2018. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10183/180530.

Council of Science Editors:

Herrera Becerra JR. Efeito analgésico da morfina e xilazina associadas à ropivacaína pela via epidural em cadelas submetidas à mastectomia unilateral total. [Masters Thesis]. Brazil; 2018. Available from: http://hdl.handle.net/10183/180530

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