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1. Dos Santos, Morgan. Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing.

Degree: Docteur es, Biologie, 2011, Université Claude Bernard – Lyon I

Parmi les protéoglycannes à héparane sulphate (HSPGs) des lames basales, le perlécane présente un rôle majeur dans la morphogénèse de l'épiderme mais également dans la survie et la différenciation des kératinocytes. Celui‐ci régulerait ces processus en contrôlant la biodisponibilité des facteurs de croissance. Au cours de ce travail, nous avons étudié l'expression du perlécane dans la peau humaine au cours du vieillissement intrinsèque et son implication dans les défauts de l'épiderme liés à l'âge. Une analyse immunohistologique sur une cohorte de peau normale humaine provenant de donneurs allant de 22 à 73 ans, a révélé une diminution drastique du perlécane au niveau de la jonction dermo‐épidermique et des capillaires dermiques au cours de l'âge. Des études biochimiques combinées à des analyses génomiques ont pu démontrer que la diminution de l'expression du perlécane n'était pas due à une dégradation de la protéine mais à une diminution de sa régulation transcriptionnelle par les kératinocytes. Par ailleurs, la conception et la caractérisation de modèles de peaux reconstruites in vitro combinant des cellules provenant de différents âges a permis d'établir une corrélation entre le défaut de synthèse du perlécane et l'épaisseur de l'épiderme. Nous avons montré que l'addition de perlécane natif purifié dans le milieu de culture d'un modèle contenant des kératinocytes âgés a permis de restaurer l'architecture épidermique. L'ensemble de ces résultats démontre ainsi l'importance du perlécane dans l'homéostasie cutanée. Un criblage de composés a permis la sélection de molécules candidates capables de restaurer spécifiquement l'expression du perlécane dans des cultures de kératinocytes et de cellules endothéliales microvasculaires dermiques âgés. Des tests fonctionnels sur les modèles de peaux reconstruites précédemment mis au point, ont permis de démontrer leur capacité à améliorer la morphogénèse de l'épiderme en accord avec les fonctions du perlécane d'origine épithéliale. L'ensemble de nos résultats indique qu'une diminution significative de synthèse du perlécane par les kératinocytes au cours de l'âge participe à l'affinement et aux défauts de différenciation de l'épiderme observés durant le vieillissement cutané

Among basement membrane heparan sulphate proteoglycans (HSPGs), perlecan is known to be involved in epidermal formation and renewal by regulating keratinocyte survival and differentiation. HSPGs are known to be regulators of growth-factor signalling through different mechanisms. We have investigated the expression of perlecan during skin ageing and have examined whether its expression correlates with age-dependant modifications of the epidermal compartment. The immunohistochemical analysis of perlecan in a cohort of human skin samples from donors of ages ranging from 22 to 73 years revealed a strong decrease of its expression with age in good correlation with reduction of the epidermal thickness. Genomic analyses of keratinocytes isolated from these biopsies combined with further characterization of…

Advisors/Committee Members: Rousselle, Patricia (thesis director).

Subjects/Keywords: Perlécane; Lame basale; Épiderme; Peau; Vieillissement; Perlecan; Basal laminae; Epiderm; Skin; Ageing; 570

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dos Santos, M. (2011). Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2011LYO10205

Chicago Manual of Style (16th Edition):

Dos Santos, Morgan. “Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing.” 2011. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed March 05, 2021. http://www.theses.fr/2011LYO10205.

MLA Handbook (7th Edition):

Dos Santos, Morgan. “Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing.” 2011. Web. 05 Mar 2021.

Vancouver:

Dos Santos M. Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2011. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2011LYO10205.

Council of Science Editors:

Dos Santos M. Rôle des protéoglycannes à héparane sulfate des lames basales au cours du vieillissement cutané : Roles of heparan sulfate proteoglycans of basal laminae during skin ageing. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2011. Available from: http://www.theses.fr/2011LYO10205

2. Sá Junior, Jarbas Joaci de Mesquita. Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas.

Degree: Mestrado, Ciências de Computação e Matemática Computacional, 2008, University of São Paulo

A taxonomia vegetal atualmente exige um grande esforço dos botânicos, desde o processo de aquisição do espécime até a morosa comparação com as amostras já catalogadas em um herbário. Nesse contexto, o projeto TreeVis surge como uma ferramenta para a identificação de vegetais por meio da análise de atributos foliares. Este trabalho é uma ramificação do projeto TreeVis e tem o objetivo de identificar vegetais por meio da análise do corte transversal de uma folha ampliado por um microscópio. Para tanto, foram extraídas assinaturas da cutícula, epiderme superior, parênquima paliçádico e parênquima lacunoso. Cada assinatura foi avaliada isoladamente por uma rede neural pelo método leave-one-out para verificar a sua capacidade de discriminar as amostras. Uma vez selecionados os vetores de características mais importantes, os mesmos foram combinados de duas maneiras. A primeira abordagem foi a simples concatenação dos vetores selecionados; a segunda, mais elaborada, reduziu a dimensionalidade (três atributos apenas) de algumas das assinaturas componentes antes de fazer a concatenação. Os vetores finais obtidos pelas duas abordagens foram testados com rede neural via leave-one-out para medir a taxa de acertos alcançada pelo sinergismo das assinaturas das diferentes partes da folha. Os experimentos consitiram na identificação de oito espécies diferentes e na identificação da espécie Gochnatia polymorpha nos ambientes Cerrado e Mata Ciliar, nas estações Chuvosa e Seca, e sob condições de Sol e Sombra

Currently, taxonomy demands a great effort from the botanists, ranging from the process of acquisition of the sample to the comparison with the species already classified in the herbarium. For this reason, the TreeVis is a project created to identify vegetal species using leaf attributes. This work is a part of the TreeVis project and aims at identifying vegetal species by analysing cross-sections of leaves amplified by a microscope. Signatures were extract from cuticle, adaxial epiderm, palisade parenchyma and sponge parenchyma. Each signature was analysed by a neural network with the leave-one-out method to verify its ability to identify species. Once the most important feature vectors were selected, two different approachs were adopted. The first was a simple concatenation of the selected feature vectors. The second, and more elaborated approach, consisted of reducing the dimensionality (three attributes only) of some component signatures before the feature vector concatenation. The final vectors obtained by these two approaches were tested by a neural network with leave-one-out to measure the correctness rate reached by the synergism of the signatures of different leaf regions. The experiments resulted in the identification of eight different species and the identification of the Gochnatia polymorpha species in Cerradão and Gallery Forest environments, Wet and Dry seasons, and under Sun and Shadow constraints

Advisors/Committee Members: Bruno, Odemir Martinez.

Subjects/Keywords: Adaxial epiderm; Bhattacharyya and Jeffrey-Matusita distance; Cuticle; Cutícula; Distância de Bhattacharyya e de Jeffrey-Matusita; Epiderme superior; Extração de características; Feature extraction; Neural networks; Palisade parenchyma; Parênquima lacunoso; Parênquima paliçádico; PCA; PCA; Redes neurais; Sponge parenchyma; Taxonomia; Taxonomy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sá Junior, J. J. d. M. (2008). Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/55/55134/tde-12052008-142428/ ;

Chicago Manual of Style (16th Edition):

Sá Junior, Jarbas Joaci de Mesquita. “Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas.” 2008. Masters Thesis, University of São Paulo. Accessed March 05, 2021. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-12052008-142428/ ;.

MLA Handbook (7th Edition):

Sá Junior, Jarbas Joaci de Mesquita. “Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas.” 2008. Web. 05 Mar 2021.

Vancouver:

Sá Junior JJdM. Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 05]. Available from: http://www.teses.usp.br/teses/disponiveis/55/55134/tde-12052008-142428/ ;.

Council of Science Editors:

Sá Junior JJdM. Identificação de espécies vegetais por meio de análise de imagens microscópicas de folhas. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/55/55134/tde-12052008-142428/ ;

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