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You searched for subject:(Ensemble Vivant). Showing records 1 – 3 of 3 total matches.

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Université du Luxembourg

1. Wienecke-Baldacchino, Anke. In Silico prediction of transcription factor binding sites by probabilistic models.

Degree: 2012, Université du Luxembourg

The characterization of in silico detected transcription factor binding sites represents a fundamental problem in the field of regulatory gene expression analysis. Several approaches have been proposed to model DNA-protein-interactions, composed by two main classes: qualitative models considering a consensus sequence and quantitative models providing a measure of binding affinity. The latter can be further subdivided in models assuming an independent contribution of the nucleotides forming a potential binding site and more flexible ones implicating a positional interdependence. In this work the applicability of three probabilistic models to predict transcription factor binding sites has been investigated: (i) the simple position weight matrix (PWM), assuming independence, and two flexible models capturing positional interdependencies represented by a (ii) Chow-Liu Tree and (iii) Ensemble of Trees model. The training and validation of the models on the Mus musculus subset of the UniPROBE database revealed that complex models provide a better predictive power suggesting a high amount of transcription factors binding motifs being affected by positional interdependencies. Additionally, numerous transcription factors were detected, for which the Ensemble of Trees model outperformed both, the Chow-Liu Tree and PWM model. The UniPROBE-based trained models have been applied in a biological context - the prediction of differential binding profiles in five different ChIP-seq samples, followed by the detection of causative regulatory SNPs. The chosen set-up involved family trio data, meaning genotype data from a family composed of father, mother and daughter, providing internal validation. The models provide strong power to correctly classify true negatives in an independent biological sample, represented by a high specificity. The applied approach to detect causative regulatory SNPs, resulted in a candidate list of 20 SNPs. Those gain strong support by epigenetic markers and both, model-based predicted binding affinity of the comprising binding site and significant p-values, describing the effect of the nucleotide exchange. Advisors/Committee Members: Balling, Rudi [superviser].

Subjects/Keywords: UniPROBE; PWM; Chow-Liu Trees; Ensemble of Trees; Regulatory SNPs; Family Trio Data; Differential Binding Detection; Machine Learning; Life sciences :: Biochemistry, biophysics & molecular biology [F05]; Sciences du vivant :: Biochimie, biophysique & biologie moléculaire [F05]

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wienecke-Baldacchino, A. (2012). In Silico prediction of transcription factor binding sites by probabilistic models. (Doctoral Dissertation). Université du Luxembourg. Retrieved from http://orbilu.uni.lu/handle/10993/15459

Chicago Manual of Style (16th Edition):

Wienecke-Baldacchino, Anke. “In Silico prediction of transcription factor binding sites by probabilistic models.” 2012. Doctoral Dissertation, Université du Luxembourg. Accessed August 22, 2019. http://orbilu.uni.lu/handle/10993/15459.

MLA Handbook (7th Edition):

Wienecke-Baldacchino, Anke. “In Silico prediction of transcription factor binding sites by probabilistic models.” 2012. Web. 22 Aug 2019.

Vancouver:

Wienecke-Baldacchino A. In Silico prediction of transcription factor binding sites by probabilistic models. [Internet] [Doctoral dissertation]. Université du Luxembourg; 2012. [cited 2019 Aug 22]. Available from: http://orbilu.uni.lu/handle/10993/15459.

Council of Science Editors:

Wienecke-Baldacchino A. In Silico prediction of transcription factor binding sites by probabilistic models. [Doctoral Dissertation]. Université du Luxembourg; 2012. Available from: http://orbilu.uni.lu/handle/10993/15459

2. Gravel, Pierre. Une région à la recherche d'un mode de fonctionnement viable.

Degree: Mémoire, Programmes d'études de cycles supérieurs en interventions régionales, 1990, Université du Québec à Chicoutimi

Comme beaucoup d'autres coins de pays sur cette planète, la région du Saguenay-Lac-St-Jean est sérieusement amochée... mais elle est encore vivante. Et elle deviendra même un véritable "laboratoire de développement durable" si elle est assez déterminée pour mettre en pratique un "mode de fonctionnement viable". Pour y arriver, l'auteur met en évidence l'importance de développer et d'utiliser une «approche d'ensemble» pour saisir ce qui se passe car les sociétés industrialisées sont trop assujetties à une pratique de spécialisation et de sectorialisation. Il est urgent de réaliser qu'une région n'est pas un territoire à développer, mais bien un système vivant qui fonctionne par lui-même et avec lequel nous co-évoluons. La conscience de ce phénomène de co-évolution est fondamentale. C'est pourquoi l'auteur rappelle les principaux processus d'organisation du phénomène de la Vie d'où se dégagent les grands principes d'autonomie et d'intégration des organismes et des systèmes vivants. Tous ces processus se manifestent dans une fabuleuse démonstration de relations symbiotiques derrière lesquelles vit chaque organisme, chaque région mais surtout, Gaïa, l'être planétaire, notre Mère-Terre. Malheureusement, la culture humaine dominante, s'est tellement éloignée de cette sagesse qu'elle est devenue un puissant processus de désintégration et de perte d'autonomie de l'ensemble des organismes et des systèmes vivants. Une réalité qui a maintenant des conséquences sur des millions d'années d'évolution biologique et écologique. Devant ce gâchis, l'auteur s'inscrit dans un mouvement qui suggère de rectifier notre mode de vie en s'inspirant des principes d'organisation de la Vie. On retrouve dans cette partie des pistes de "fonctionnement viable" pour la personne. On y scrute des pistes d'action municipale. Et il s'y dégage une pratique régionale en matière d'unité, de sécurité, d'éducation... et de coopération. Un message revient souvent: "c'est avant tout chaque personne?. et chaque région qui doit se donner une pratique pour remettre dans leurs justes proportions autonomie et dépendance, intégration et désintégration, de même que symbiose et compétition".

Subjects/Keywords: Philosophie de la nature – Québec (Province) – Saguenay-Lac-Saint-Jean; Philosophy of nature – Quebec (Province) – Saguenay-Lac-Saint-Jean; 02; APPROCHE; AUTONOMIE; DESINTEGRATION; ENSEMBLE; FONCTIONNEMENT; INTEGRATION; LAC-SAINT-JEAN; MODE; NATURE; ORGANISME; PERTE; REGION; SAGUENAY; SAGUENAY-LAC-SAINT-JEAN; SYSTEME; THESE; VIABLE; VIE; VIVANT

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APA (6th Edition):

Gravel, P. (1990). Une région à la recherche d'un mode de fonctionnement viable. (Thesis). Université du Québec à Chicoutimi. Retrieved from http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QCU/TC-QCU-1552.pdf ; http://constellation.uqac.ca/1552/1/1463069.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gravel, Pierre. “Une région à la recherche d'un mode de fonctionnement viable.” 1990. Thesis, Université du Québec à Chicoutimi. Accessed August 22, 2019. http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QCU/TC-QCU-1552.pdf ; http://constellation.uqac.ca/1552/1/1463069.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gravel, Pierre. “Une région à la recherche d'un mode de fonctionnement viable.” 1990. Web. 22 Aug 2019.

Vancouver:

Gravel P. Une région à la recherche d'un mode de fonctionnement viable. [Internet] [Thesis]. Université du Québec à Chicoutimi; 1990. [cited 2019 Aug 22]. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QCU/TC-QCU-1552.pdf ; http://constellation.uqac.ca/1552/1/1463069.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gravel P. Une région à la recherche d'un mode de fonctionnement viable. [Thesis]. Université du Québec à Chicoutimi; 1990. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QCU/TC-QCU-1552.pdf ; http://constellation.uqac.ca/1552/1/1463069.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Wilson, Catherine Elizabeth. Music and Healing: Progress Towards Elysium.

Degree: PhD, Music, 2017, York University

This dissertation explores some of the many roles music, as a healing and nurturing art, plays in support of health and wellness. The fundamental question is how does music nurture, revive, animate, and inspire us to lead healthier and richer lives? Historical and modern sources, ranging from ancient philosophical works to reports of laboratory-based investigations, suggests that music is a remarkably positive and therapeutic element in the development of happier, healthier individuals, and well-adjusted societies. This study is the outcome of three deeply personal impulses: a) the experience of one who has personally benefited from music as a healing balm; b) the performer's desire to better understand the positive reactions, both emotional and physical, of audiences to specific musical selections and genres; and c) growing evidence that society is weakened and dulled (nor can foot feel, being shod) by the loss of the collective experience of live music due to the proliferation of digital technologies that facilitate access to a complexity of recorded music choices. There is compelling scientific documentation that experience listening to and creating live music when very young is especially beneficial. If the positive seeds of music are not planted in youth, the continued disintegration of the long-standing cultural musical institutions that serve a vital role in maintaining the social fabric is threatened. The dissertation documents the authors own response to the diminution of opportunities for participation in live music: the establishment of Euterpe, a non-profit charitable organization that presents live interactive classical and jazz performance programs for children in the public school system. The work is captured and analyzed in several ways: video recordings; art work produced by the children during Euterpe programs, and analysis extracted from previously published Qualitative Research Studies which were designed by leading scientific researchers in the field. Advisors/Committee Members: Coghlan, Michael (advisor).

Subjects/Keywords: Philosophy of education; Music; Music and healing; Music and mysticism; Euterpe; Ensemble Vivant; Live music of classical and jazz and related popular styles; Music education; Music and the mind; Music and Plato; Music and ancient cultures; Music healing and ancient cultures; Music healing and neuroscience; Oliver Sacks and Musicophilia; Music and angels; Music and subtler bodies; Music and child development; Music and self-esteem; Music and spiritual health; Music and physical health; Music and emotional health; Music and mental health; Music is the Key DVD euterpemusicarts.com; Music and elysium; Music and happier healthier individuals; Music and happier healthier communities; Music and happier healthier well-adjusted societies and nations; Therapeutic benefits of live music and music education; Catherinewilson.com

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wilson, C. E. (2017). Music and Healing: Progress Towards Elysium. (Doctoral Dissertation). York University. Retrieved from http://hdl.handle.net/10315/33347

Chicago Manual of Style (16th Edition):

Wilson, Catherine Elizabeth. “Music and Healing: Progress Towards Elysium.” 2017. Doctoral Dissertation, York University. Accessed August 22, 2019. http://hdl.handle.net/10315/33347.

MLA Handbook (7th Edition):

Wilson, Catherine Elizabeth. “Music and Healing: Progress Towards Elysium.” 2017. Web. 22 Aug 2019.

Vancouver:

Wilson CE. Music and Healing: Progress Towards Elysium. [Internet] [Doctoral dissertation]. York University; 2017. [cited 2019 Aug 22]. Available from: http://hdl.handle.net/10315/33347.

Council of Science Editors:

Wilson CE. Music and Healing: Progress Towards Elysium. [Doctoral Dissertation]. York University; 2017. Available from: http://hdl.handle.net/10315/33347

.