subject:(Endocrinology AND Animal Biosciences)

Rutgers University

1. Zhu, Qiaoqiao, 1991-. Crosstalk between long non-coding RNAs and circadian chromatin.

Degree: PhD, Circadian rhythms, 2020, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/64311/

►

The circadian rhythm is governed by transcriptional negative feedback facilitated by oscillating histone modifications and chromatin remodeling. The circadian rhythm is entrained by external zeitgebers… (more)

▼

The circadian rhythm is governed by transcriptional negative feedback facilitated by oscillating histone modifications and chromatin remodeling. The circadian rhythm is entrained by external zeitgebers (light and temperature) and are conserved in Neurospora, Drosophila, zebrafish, and mammals. The clock gene frequency in Neurospora and Period2 in vertebrates have natural antisense transcripts (NATs) whose function is not understood. In this dissertation I examined the connection among the circadian clock, non-coding RNAs and heterochromatin formation on both on the genome-wide and locus-specific level using a multi-organism approach. I performed a genome-wide study, using RNA-seq and ChIP-seq to understand the role of H3 lysine 4 methyltransferase (KMT2/SET-1) and histone H3 lysine 9 methyltransferase (KMT1/DIM-5) in Neurospora to understand the role of 2 seemingly opposing modifications. Integrated analysis of RNA-seq and ChIP-seq showed crosstalk and redistributions between histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3). I also examined how perturbing the expression of a diurnal lncRNA affected downstream heterochromatin formation at the telomeres. The core circadian clock controls rhythms in TERRA, a long noncoding RNA that originates from telomeres and my research shows alcohol disrupts the diurnal rhythm in TERRA and heterochromatin at the telomere, which in theory makes telomeres more susceptible to DNA damage. I also examined the Per2 NAT, Per2AS and found the diurnal rhythm in Per2AS is dependent on BMAL1. Using the ChIRP-MS, I identified Per2AS-interacting proteins. Specifically, I found hnRNP M interacts with Per2AS and hnRNP M is required to maintain the normal amplitude and period of Per2. Furthermore, I demonstrate that hnRNP M is necessary for H3K9me3 and H3K27me3 at Per2. These findings support a model where Per2AS may serve as scaffold for hnRNP M and other associated proteins that assist in heterochromatin formation at Per2. Collectively, this dissertation furthers our understanding of the circadian clock, non-coding RNAs, and circadian regulated facultative heterochromatin formation.

Advisors/Committee Members: Belden, William J. (chair), Anthony, Tracy G (internal member), Sarkar, Dipak (internal member), Lee, KiBum (outside member), School of Graduate Studies.

Subjects/Keywords: Ribonucleases; Endocrinology and Animal Biosciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhu, Qiaoqiao, 1. (2020). Crosstalk between long non-coding RNAs and circadian chromatin. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/64311/

Chicago Manual of Style (16^th Edition):

Zhu, Qiaoqiao, 1991-. “Crosstalk between long non-coding RNAs and circadian chromatin.” 2020. Doctoral Dissertation, Rutgers University. Accessed January 18, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/64311/.

MLA Handbook (7^th Edition):

Zhu, Qiaoqiao, 1991-. “Crosstalk between long non-coding RNAs and circadian chromatin.” 2020. Web. 18 Jan 2021.

Vancouver:

Zhu, Qiaoqiao 1. Crosstalk between long non-coding RNAs and circadian chromatin. [Internet] [Doctoral dissertation]. Rutgers University; 2020. [cited 2021 Jan 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64311/.

Council of Science Editors:

Zhu, Qiaoqiao 1. Crosstalk between long non-coding RNAs and circadian chromatin. [Doctoral Dissertation]. Rutgers University; 2020. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64311/

Cornell University

2. Caixeta, Luciano Souza. MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS.

Degree: PhD, Animal Science, 2017, Cornell University

URL: http://hdl.handle.net/1813/51569

► The mineral and energy imbalances of the transition period of dairy cows have a negative impact in the dairy industry because they are prevalent, contribute… (more)

▼ The mineral and energy imbalances of the transition period of dairy cows have a negative impact in the dairy industry because they are prevalent, contribute to economic losses and are an animal welfare issue. This dissertation aimed to advance our understanding of the physiological adaptations characteristic of this period. A series of experiments were conducted to: advance the understanding of body reserves mobilization around parturition, characterize the dynamics of blood calcium concentration after calving and evaluate its association with reproductive performance, and advance the understanding of the regulation of fibroblast growth factor 21 in the dairy cow. Chapter 2 reviews the current information available regarding the physiological adaptations necessary to overcome the mineral and energy challenges faced by dairy cows in the periparturient period, with an emphasis in subclinical hypocalcemia and fibroblast growth factor 21. In Chapter 3, it is reported that blood calcium concentration is the lowest in the first day post-partum, independently of parity, but normal levels are regained by day 3 of lactation. Additionally, the interaction between subclinical hypocalcemia, disease occurrence, and increased levels of metabolites surrogates of negative energy balance significantly influence the loss of body weight in parity > 3 animals. Chapter 4 introduces a new concept of subclinical hypocalcemia that considers not only the blood calcium concentration at a given time but also how many days post-partum blood calcium concentration is below the established cut-off point. In this chapter, it is reported that approximately 1/3 of the dairy cows have low blood calcium concentration during the first 3 days in lactation. Additionally, chronic subclinical hypocalcemia was associated with impaired reproductive performance of these animals. Chapter 5 aims to identify objective measurements to assess body condition in dairy cows. In this chapter, sequential measurement of body weight and the measurement of back-fat thickness were compared to the traditional visual body condition scoring system. It was determined that body weight has the potential to be used to predict milk production throughout lactation, but other variables (i.e. disease and negative energy balance) can significant interfere with this measurement and further investigation of this methodology is necessary prior to the diffusion of this technique through the dairy industry at large. Finally in Chapter 6, we demonstrated the importance of elevated plasma non-esterified fatty acids in hepatic fibroblast growth factor 21 production and consequently the increased circulating levels of this this hormone. In summary, this dissertation contributes to the current knowledge regarding various aspects of dairy cows adaptation to milk production. Nonetheless, further research is needed to advance our knowledge on the epidemiology of subclinical hypocalcemia and its influence in production outcomes. As well as to better understand the… Advisors/Committee Members: Boisclair, Yves R (chair), Nydam, Daryl V (committee member), Amburgh, Michael V (committee member), Giordano, Julio O (committee member).

Subjects/Keywords: Epidemiology; Animal sciences; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Caixeta, L. S. (2017). MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/51569

Chicago Manual of Style (16^th Edition):

Caixeta, Luciano Souza. “MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS.” 2017. Doctoral Dissertation, Cornell University. Accessed January 18, 2021. http://hdl.handle.net/1813/51569.

MLA Handbook (7^th Edition):

Caixeta, Luciano Souza. “MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS.” 2017. Web. 18 Jan 2021.

Vancouver:

Caixeta LS. MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS. [Internet] [Doctoral dissertation]. Cornell University; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1813/51569.

Council of Science Editors:

Caixeta LS. MINERAL AND ENERGY IMBALANCES OF THE TRANSITION PERIOD IN DAIRY COWS. [Doctoral Dissertation]. Cornell University; 2017. Available from: http://hdl.handle.net/1813/51569

3. Ellestad, Laura E. Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system.

Degree: 2011, University of Maryland, College Park

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3443557

► The neuroendocrine system is a critical regulator of vertebrate homeostasis that includes five hypothalamic-pituitary axes which develop during embryogenesis. Adrenal glucocorticoids play an important… (more)

▼ The neuroendocrine system is a critical regulator of vertebrate homeostasis that includes five hypothalamic-pituitary axes which develop during embryogenesis. Adrenal glucocorticoids play an important role in functional maturation of the anterior pituitary through initiation of growth hormone (GH) production. These studies were aimed at characterizing ontogenic and glucocorticoid-regulated changes in gene expression during neuroendocrine system development in the chick. First, to ascertain timing of initiation and establishment of each neuroendocrine axis, we measured mRNA levels of hypothalamic regulatory factors, their pituitary receptors, and pituitary hormones from embryonic day (e) 10 through post-hatch day (d) 7. We found that the adrenocorticotropic axis is the first to be established (e12), followed by establishment of the thyrotropic (e18), somatotropic (e20), lactotropic (d1), and gonadotropic (d5) axes. Next, we examined in detail mechanisms through which glucocorticoids initiate pituitary GH expression during embryogenesis. We determined that glucocorticoids elevate GH mRNA levels on e11 by increasing transcriptional activity of the GH gene rather than enhancing mRNA stability, and protein synthesis, histone deacetylase activity, ras signaling, and ERK1/2 signaling are required for this activation. Conversely, sustained activation of ERK1/2 and p38MAPK pathways reduced glucocorticoid stimulation of GH expression, indicating the requirement for ERK1/2 activity is transitory. Finally, we identified ras-dva as a novel Pit-1 and glucocorticoid-regulated gene in the chicken embryonic pituitary gland. Pituitary ras-dva mRNA levels increased between e10 and e18, decreased just prior to hatch, and remained low or undetectable post-hatch. Ras-dva expression was highly enriched within the pituitary gland on e18, and glucocorticoids rapidly induced ras-dva mRNA in cultured pituitary cells through a mechanism involving transcriptional activation. Potential regulatory elements within the 5’-flanking region of chicken ras-dva responsible for pituitary-specific expression were identified, as was a 2 kb fragment necessary for its glucocorticoid induction in embryonic pituitary cells. These results enhance our understanding of neuroendocrine system development and establishment during embryogenesis, reveal mechanisms underlying glucocorticoid initiation of GH expression in somatotrophs, and identify a new Pit-1 and glucocorticoid target gene that may play an important role in pituitary development.

Subjects/Keywords: Biology, Molecular; Biology, Endocrinology; Biology, Animal Physiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ellestad, L. E. (2011). Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system. (Thesis). University of Maryland, College Park. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3443557

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ellestad, Laura E. “Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system.” 2011. Thesis, University of Maryland, College Park. Accessed January 18, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3443557.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ellestad, Laura E. “Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system.” 2011. Web. 18 Jan 2021.

Vancouver:

Ellestad LE. Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system. [Internet] [Thesis]. University of Maryland, College Park; 2011. [cited 2021 Jan 18]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3443557.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ellestad LE. Ontogenic and glucocorticoid-regulated gene expression in the developing neuroendocrine system. [Thesis]. University of Maryland, College Park; 2011. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3443557

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

4. Lemley, Caleb Owens. Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows.

Degree: PhD, Animal and Nutritional Sciences, 2010, West Virginia University

URL: https://doi.org/10.33915/etd.3085 ; https://researchrepository.wvu.edu/etd/3085

► In the cow, inadequate concentrations of progesterone during gestation may lead to an abrupt termination of pregnancy. The primary organ involved in progesterone catabolism is… (more)

▼ In the cow, inadequate concentrations of progesterone during gestation may lead to an abrupt termination of pregnancy. The primary organ involved in progesterone catabolism is the liver, which contains an abundance of cytochrome P450 isozymes (CYP; EC 1.14.14.1) and aldo-keto reductases (AKR; EC 1.1.1.145-151), which are involved in the first phase of steroid inactivation, before second phase conjugation and excretion of the steroid metabolite by UDP-glucuronosyltransferases (UGT; EC 2.4.1.17). The objectives of the current experiments were to: (1) determine the effect of feeding two isoenergetic and isonitrogenous diets formulated to cause divergent insulin secretion, on hepatic progesterone catabolic enzyme activity (CYP2C, CYP3A and AKR1C), as well as progesterone clearance, and (2) determine the relative contributions of CYP2C, CYP3A, AKR1C and UGT enzymes to total progesterone decay in primary bovine hepatic cell cultures. In the first set of experiments, Holstein cows were randomly assigned to either a high cornstarch or a high fiber diet in a cross-over experimental design consisting of two 14 d periods at the WVU animal sciences farm (n=22) or the NDSU dairy research barn (n=11). Dry matter intake and milk yield were similar between the two diets. Energy balance was improved in cows consuming the high cornstarch diet. Insulin concentrations were elevated in cows consuming the high cornstarch diet versus the high fiber diet. Both CYP2C and CYP3A activity were decreased in cows consuming the high cornstarch diet, while AKR1C tended to be lower in NDSU cows fed the high cornstarch diet. The half-life of progesterone was longer in cows fed the high cornstarch diet versus the high fiber diet. In NDSU cows, liver blood flow was similar between the two diets (1891 +/- 91 l/h), while the metabolic clearance rate of progesterone tended to be lower in cows fed the high cornstarch diet (25 +/- 5 l/h*BW0.75) versus the high fiber diet (40 +/- 6 l/h*BW0.75). In the second experiment, the contribution of CYP2C and CYP3A enzymes to progesterone inactivation in bovine hepatic cell cultures was 40% and 15%, respectively. Depending on the inhibitor used, it would appear that the aldo-keto reductase enzymes contribute ∼40% to the observed progesterone decay; although, a portion of this inactivation may be due to the loss of UGT activity. In summary, cows consuming the high cornstarch diet had elevated insulin concentrations, lower hepatic progesterone catabolic enzyme activity and lower progesterone clearance compared to cows consuming the high fiber diet. The majority of progesterone inactivation occurs via hepatic CYP2C, CYP3A and AKR1C activity and inhibiting these enzymes will increase the bioavailability of progesterone. Therefore, feeding diets that stimulate insulin secretion could alter progesterone clearance during lactation by decreasing hepatic progesterone catabolic enzyme activity. This dietary relationship could be used to increase progesterone bioavailability in dairy cows that have increased progesterone… Advisors/Committee Members: Matthew E. Wilson..

Subjects/Keywords: Animal sciences; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lemley, C. O. (2010). Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.3085 ; https://researchrepository.wvu.edu/etd/3085

Chicago Manual of Style (16^th Edition):

Lemley, Caleb Owens. “Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows.” 2010. Doctoral Dissertation, West Virginia University. Accessed January 18, 2021. https://doi.org/10.33915/etd.3085 ; https://researchrepository.wvu.edu/etd/3085.

MLA Handbook (7^th Edition):

Lemley, Caleb Owens. “Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows.” 2010. Web. 18 Jan 2021.

Vancouver:

Lemley CO. Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows. [Internet] [Doctoral dissertation]. West Virginia University; 2010. [cited 2021 Jan 18]. Available from: https://doi.org/10.33915/etd.3085 ; https://researchrepository.wvu.edu/etd/3085.

Council of Science Editors:

Lemley CO. Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows. [Doctoral Dissertation]. West Virginia University; 2010. Available from: https://doi.org/10.33915/etd.3085 ; https://researchrepository.wvu.edu/etd/3085

University of Maryland

5. El-Ibiary, Hussein Mahmoud. Contribution to the genetics of growth in chickens as influenced by the thyroid gland.

Degree: 1950, University of Maryland

URL: http://hdl.handle.net/1903/17739

Subjects/Keywords: Animal sciences; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El-Ibiary, H. M. (1950). Contribution to the genetics of growth in chickens as influenced by the thyroid gland. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17739

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

El-Ibiary, Hussein Mahmoud. “Contribution to the genetics of growth in chickens as influenced by the thyroid gland.” 1950. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/17739.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

El-Ibiary, Hussein Mahmoud. “Contribution to the genetics of growth in chickens as influenced by the thyroid gland.” 1950. Web. 18 Jan 2021.

Vancouver:

El-Ibiary HM. Contribution to the genetics of growth in chickens as influenced by the thyroid gland. [Internet] [Thesis]. University of Maryland; 1950. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/17739.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

El-Ibiary HM. Contribution to the genetics of growth in chickens as influenced by the thyroid gland. [Thesis]. University of Maryland; 1950. Available from: http://hdl.handle.net/1903/17739

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Portland State University

6. Glaeser, Sharon Stuart. Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes.

Degree: PhD, Biology, 2020, Portland State University

URL: https://pdxscholar.library.pdx.edu/open_access_etds/5545

► In this body of research, reproductive and adrenal hormones and behavior were used to evaluate individual and group responses to physiological, social, and environmental… (more)

▼ In this body of research, reproductive and adrenal hormones and behavior were used to evaluate individual and group responses to physiological, social, and environmental changes in zoo-housed Asian elephants, considering factors of sex, age, and life stage. Animals experience physiological, social, and environmental changes as part of their natural history and individual life experience. Measures of both positive and negative states are needed to assess the impact of these changes at the individual and group level. Such measures can help us better understand how animals cope with a changing environment, and can help inform management decisions. Through longitudinal analyses of more than 20 years of gonadal and adrenal hormone data (Chapters 2 and 3), we confirmed the presence of intrinsic glucocorticoid (GC) patterns associated with reproductive state in male and female Asian elephants, providing further evidence that GCs play a role in normal reproductive function. In females, circulating cortisol was higher in the follicular phase compared to the luteal phase of the ovarian cycle, and highest in lactational anestrous compared to all other reproductive states. In bulls, circulating cortisol covaried positively with testosterone and musth, as observed in previous studies of elephants and during the analogous condition of rut in other ungulates. Age-related changes in cortisol were observed in both sexes, and some individuals experienced higher rates of change in cortisol in one phase of their reproductive cycle versus another. In bulls, testosterone increased after puberty but decreased with advancing age. Concentrations of GCs covaried more consistently with physiological changes than with social changes in both sexes. Overall, the elephants in these studies showed adaptive adrenal responses to change, and they also exhibited substantial individuality in adrenal response to social life events. These findings reinforce the need to assess welfare on an individual basis and to consider factors influencing the impact of perceived stressors, such as social support, temperament, and life history. The study conducted to monitor an elephant herd through transition to a new habitat (Chapter 4) provided further insights on habitat features that help us meet the physiological, psychological and social needs of elephants under human care, and helped identify which of those features may be most beneficial for enhancing welfare. The complexity and flexibility of the new habitat was effective in improving overall health and welfare by encouraging activity and providing meaningful challenges and the opportunity to express more appetitive behaviors. The new habitat also offered increased control over environmental conditions and social interactions, and the space and resource distribution helped to support changing herd dynamics and greater social equity. Overall, these studies helped deepen our understanding of Asian elephant physiology, and highlight the importance of taking intrinsic patterns of hormone secretion into account… Advisors/Committee Members: Deborah Lutterschmidt.

Subjects/Keywords: Environmental enrichment (Animal culture); Asiatic elephant – Endocrinology; Glucocorticoids; Animal behavior – Endocrine aspects; Asiatic elephant – Physiology; Reproduction; Animal welfare; Biology; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glaeser, S. S. (2020). Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes. (Doctoral Dissertation). Portland State University. Retrieved from https://pdxscholar.library.pdx.edu/open_access_etds/5545

Chicago Manual of Style (16^th Edition):

Glaeser, Sharon Stuart. “Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes.” 2020. Doctoral Dissertation, Portland State University. Accessed January 18, 2021. https://pdxscholar.library.pdx.edu/open_access_etds/5545.

MLA Handbook (7^th Edition):

Glaeser, Sharon Stuart. “Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes.” 2020. Web. 18 Jan 2021.

Vancouver:

Glaeser SS. Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes. [Internet] [Doctoral dissertation]. Portland State University; 2020. [cited 2021 Jan 18]. Available from: https://pdxscholar.library.pdx.edu/open_access_etds/5545.

Council of Science Editors:

Glaeser SS. Assessing Well-being of Asian Elephants (Elephas maximus) Through Major Events and Transitions, with Development and Aging, and Husbandry Changes. [Doctoral Dissertation]. Portland State University; 2020. Available from: https://pdxscholar.library.pdx.edu/open_access_etds/5545

Penn State University

7. Michael, Kerry Colleen. SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH.

Degree: 2011, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/12157

► Sensation-seeking and behavioral inhibition are two behavioral traits that have distinct biological profiles as well as distinct mental and physical health outcomes. These behavioral traits… (more)

▼ Sensation-seeking and behavioral inhibition are two behavioral traits that have distinct biological profiles as well as distinct mental and physical health outcomes. These behavioral traits and health outcomes are also influenced by life experiences. This dissertation explores the hormonal, immune, and social underpinnings of sensation-seeking and behavioral inhibition in humans and in rats, to provide insight into how these traits might contribute to certain health outcomes, specifically depression. Chapter 1 is a broad overview of sensation-seeking, behavioral inhibition, and the biological and sociological contributors to these traits. Chapter 2 is a review of temperamental traits in animals and the utility of animal models to study the relationship between personality and immune function and health, which provides the basis for the animal-human comparisons made in the following chapters. Chapter 3 describes a study based on an animal model, Sprague-Dawley rats, to investigate how innate and adaptive immune responses to antigen differ between exploratory versus inhibited rats. Results showed that inhibited animals had a greater innate response to lipopolysaccharide but a lower adaptive immune response as evidenced by lower delayed-type hypersensitivity in response to re-exposure to keyhole limpet hemocyanin. This evidence suggests a TH2 bias in the immune system of inhibited rats. Chapter 4 examined the hormonal underpinnings of sensation-seeking in young women and assessed how these relationships were moderated by gender role identification. Results from this study showed that androstenedione, a hormone previously unexplored in regards to sensation-seeking, was associated with sensation-seeking in women. The direction of the association, however, was dependent on identification with gender role – positive in women who identified as more masculine or with no gender role, and negative in women who identified as more feminine. There was no association in women who identified as both masculine and feminine. Chapter 5 uses a similar method to Chapter 4, but added C-reactive protein as a marker of inflammation, and men were recruited as participants as well as women. These additions allowed for a comparison between men and women, as well as examining one of the major physiological factors involved with depression – inflammation. Results showed that Thrill and Adventure Seeking was protective against depression in both men and women. Furthermore, CRP was associated with sensation-seeking, but again the direction of the association was dependent on gender role: positive in masculine women and negative in feminine women. Chapter 6 concludes the dissertation and discusses implications and suggestions for future research. Advisors/Committee Members: Sonia Angele Cavigelli, Dissertation Advisor/Co-Advisor, Sonia Angele Cavigelli, Committee Chair/Co-Chair, Elizabeth Susman, Committee Member, Roger John Mccarter, Committee Member, Robert Harold Bonneau, Committee Member, Jennifer Graham, Committee Member.

Subjects/Keywords: gender; sensation-seeking; immune; sex hormone; animal behavior; endocrinology; immunology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michael, K. C. (2011). SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12157

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Michael, Kerry Colleen. “SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH.” 2011. Thesis, Penn State University. Accessed January 18, 2021. https://submit-etda.libraries.psu.edu/catalog/12157.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Michael, Kerry Colleen. “SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH.” 2011. Web. 18 Jan 2021.

Vancouver:

Michael KC. SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH. [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Jan 18]. Available from: https://submit-etda.libraries.psu.edu/catalog/12157.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Michael KC. SOCIAL AND PHYSIOLOGICAL PROCESSES UNDERLYING SENSATION-SEEKING AND BEHAVIORAL INHIBITION: POTENTIAL MECHANISMS LINKING PERSONALITY TO HEALTH. [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12157

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

8. Goravanahally, Madhusudan P. Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha.

Degree: PhD, Biology, 2009, West Virginia University

URL: https://doi.org/10.33915/etd.4470 ; https://researchrepository.wvu.edu/etd/4470

► Prostaglandin F2 alpha (PGF2alpha) brings about regression of the bovine corpus luteum (CL). This luteolytic property of PGF 2alpha is used in beef and dairy… (more)

▼ Prostaglandin F2 alpha (PGF2alpha) brings about regression of the bovine corpus luteum (CL). This luteolytic property of PGF 2alpha is used in beef and dairy cattle to synchronize estrus. A limitation of this protocol is an insensitivity of the early CL to luteolytic actions of PGF2alpha. The mechanisms underlying this differential luteal sensitivity are poorly understood. Therefore the main objective of the current study is to understand the cellular mechanism of luteal insensitivity. The developing CL has a maximum number of PGF2alpha receptors; therefore differences in signaling events might be responsible for luteal insensitivity. Hence differential gene expression at two developmental stages of CL, days 4 (D-4) and 10 (D-10) post estrus, might account for differences in signal transduction pathways associated with luteal sensitivity. For example, differential expression of protein kinase C epsilon (PKCepsilon /PRKCE) and its ability to regulate PGF2alpha-stimulated rise in intracellular calcium concentration have been proposed to be part of luteal resistance mechanism. Therefore the current study investigates the: (1) physiological role of PRKCE in regulating the ability of PGF2alpha to inhibit progesterone synthesis, (2) role of PGF2alpha-stimulated rise in intracellular calcium in progesterone inhibitory actions of PGF2alpha, (3) differential expression of a large portion of the luteal transcriptome during its developmental transition from early to mature stage, and (4) role of differentially expressed CAMKK2 in acquisition of luteolytic sensitivity to PGF2alpha . Down-regulation of PRKCE significantly reduced the ability of PGF 2alpha to inhibit LH-stimulated progesterone accumulation. A pharmacological increase in intracellular calcium concentration [Ca2+] i significantly inhibited LH-stimulated progesterone accumulation irrespective of luteal developmental stage. More importantly, buffering the rise in [Ca 2+]i reduced the ability of PGF2alpha to inhibit progesterone accumulation. Microarray analysis identified 167 genes that were expressed differentially (p < 0.05). These were categorized into genes involved in cell signaling (12%), steroidogenesis and metabolism (10.2%), protein degradation (5.3%), transcription regulation and DNA biosynthesis (18.5%), protein biosynthesis and modification (18.5%), extracellular matrix and cytoskeletal proteins (9.5%), antioxidant property (3%), miscellaneous (17%), and unknown functions (6%). In addition, the in vivo administration of PGF2alpha increased the expression of a guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1) in D-4 CL and calcium/calmodulin dependent kinase kinase 2, beta (CAMKK2) in D-10 CL. Furthermore, large and small luteal steroidogenic cells, known to be targets for actions of PGF2alpha were demonstrated to be a cellular source for CAMKK2. More importantly, in vitro, a CAMKK2 inhibitor significantly reduced the ability of PGF2alpha to inhibit progesterone accumulation. In summary, a developmental increase in PRKCE expression… Advisors/Committee Members: Jorge A Flores.

Subjects/Keywords: Animal Physiology; Molecular biology; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goravanahally, M. P. (2009). Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4470 ; https://researchrepository.wvu.edu/etd/4470

Chicago Manual of Style (16^th Edition):

Goravanahally, Madhusudan P. “Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha.” 2009. Doctoral Dissertation, West Virginia University. Accessed January 18, 2021. https://doi.org/10.33915/etd.4470 ; https://researchrepository.wvu.edu/etd/4470.

MLA Handbook (7^th Edition):

Goravanahally, Madhusudan P. “Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha.” 2009. Web. 18 Jan 2021.

Vancouver:

Goravanahally MP. Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha. [Internet] [Doctoral dissertation]. West Virginia University; 2009. [cited 2021 Jan 18]. Available from: https://doi.org/10.33915/etd.4470 ; https://researchrepository.wvu.edu/etd/4470.

Council of Science Editors:

Goravanahally MP. Cellular mechanisms responsible for development of sensitivity of the bovine corpus luteum to prostaglandin F2 alpha. [Doctoral Dissertation]. West Virginia University; 2009. Available from: https://doi.org/10.33915/etd.4470 ; https://researchrepository.wvu.edu/etd/4470

University of Maryland

9. Garren, Henry Wilburn. An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress.

Degree: 1953, University of Maryland

URL: http://hdl.handle.net/1903/17679

Subjects/Keywords: Animal sciences; Endocrinology; Physiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garren, H. W. (1953). An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garren, Henry Wilburn. “An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress.” 1953. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/17679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garren, Henry Wilburn. “An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress.” 1953. Web. 18 Jan 2021.

Vancouver:

Garren HW. An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress. [Internet] [Thesis]. University of Maryland; 1953. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/17679.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garren HW. An investigation of the morphological changes, hormonal influences, and genetic factors concerned in the response of young chickens to conditions of stress. [Thesis]. University of Maryland; 1953. Available from: http://hdl.handle.net/1903/17679

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Arizona State University

10. Mennenga, Sarah Elaine. Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat.

Degree: MA, Psychology, 2012, Arizona State University

URL: http://repository.asu.edu/items/15941

► Ethinyl estradiol, (EE) a synthetic, orally bio-available estrogen, is the most commonly prescribed form of estrogen in oral contraceptives (Shively, C., 1998), and is found… (more)

Subjects/Keywords: Animal behavior; Endocrinology; Neurosciences; Contraceptive; Ethinyl Estradiol; Memory; Rodent

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mennenga, S. E. (2012). Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat. (Masters Thesis). Arizona State University. Retrieved from http://repository.asu.edu/items/15941

Chicago Manual of Style (16^th Edition):

Mennenga, Sarah Elaine. “Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat.” 2012. Masters Thesis, Arizona State University. Accessed January 18, 2021. http://repository.asu.edu/items/15941.

MLA Handbook (7^th Edition):

Mennenga, Sarah Elaine. “Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat.” 2012. Web. 18 Jan 2021.

Vancouver:

Mennenga SE. Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat. [Internet] [Masters thesis]. Arizona State University; 2012. [cited 2021 Jan 18]. Available from: http://repository.asu.edu/items/15941.

Council of Science Editors:

Mennenga SE. Dose and delivery method impact cognitive outcome of Ethinyl Estradiol administration in the surgically menopausal rat. [Masters Thesis]. Arizona State University; 2012. Available from: http://repository.asu.edu/items/15941

The Ohio State University

11. Hall, Melanie J. Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats.

Degree: MS, Comparative and Veterinary Medicine, 2014, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641

► GLP-1 is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion and increasing beta cell mass, satiety and gastric-emptying time.… (more)

Subjects/Keywords: Animal Diseases; Animal Sciences; Animals; Endocrinology; Veterinary Services; feline, diabetes, insulin, glucagon, incretin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hall, M. J. (2014). Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641

Chicago Manual of Style (16^th Edition):

Hall, Melanie J. “Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats.” 2014. Masters Thesis, The Ohio State University. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641.

MLA Handbook (7^th Edition):

Hall, Melanie J. “Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats.” 2014. Web. 18 Jan 2021.

Vancouver:

Hall MJ. Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats. [Internet] [Masters thesis]. The Ohio State University; 2014. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641.

Council of Science Editors:

Hall MJ. Pharmacology of the GLP-1 Analog Liraglutide in Healthy Cats. [Masters Thesis]. The Ohio State University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1405949641

Iowa State University

12. Ganesan, Shanthi. Cellular and molecular mechanisms of chemical-induced ovarian toxicity.

Degree: 2014, Iowa State University

URL: https://lib.dr.iastate.edu/etd/14149

► The ovary is the ovum-producing female reproductive organ composed of follicles at different stages of development. Chemicals which selectively damage large growing or antral follicles… (more)

▼ The ovary is the ovum-producing female reproductive organ composed of follicles at different stages of development. Chemicals which selectively damage large growing or antral follicles only temporarily interrupt reproductive function because these follicles can be replaced by recruitment from the greater pool of primordial follicles. However, chemicals that destroy oocytes contained in primordial follicles can cause permanent infertility and premature ovarian failure (early menopause in women), since once a primordial follicle is destroyed, it cannot be replaced. We hypothesized that ovotoxic chemicals can bind to DNA to induce DNA damage and that the ovarian cells activate DNA repair, cell cycle arrest and apoptosis to cause chemical-induced toxicity. Additionally, we investigated cell to cell communication as targets of ovotoxicants. Gap junction proteins are involved in folliculogenesis and we questioned whether an external factor such as ovotoxicant exposure and obesity alters gap junction proteins to cause follicle loss. To test this hypothesis, ovarian mRNA and protein expression profiles involved in DNA repair, cell cycle arrest, apoptosis and gap junction formation were quantified using qRT-PCR, western blotting or immunohistochemistry techniques after exposure to two different chemicals: Phosphoramide mustard (PM) and 7,12-dimethylbenz[a]anthracene (DMBA). In addition, we investigated the impact of PM and/or DMBA in three physiological paradigms: 1) spontaneously immortalized rat granulosa cells (SIGC); 2) In vitro neonatal ovarian culture system; 3) In vivo obese mouse model. Overall, our data demonstrates that the ovarian DNA damage responses are activated and up-regulated in both a dose- and time-dependent manner. Also, chemical exposure alters the gap junction protein expression in ovaries, interfering with inter-cellular communication, leading to follicular demise. Taken together, our discoveries detailed herein shed new mechanistic light on the events that precipitate ovarian follicle depletion leading to female infertility, and potential targets for prevention of chemical-induced infertility are described.

Subjects/Keywords: Toxicology; Apoptosis; DNA damage; Ovary; Reproductive toxicology; Agriculture; Animal Sciences; Endocrinology; Endocrinology, Diabetes, and Metabolism; Reproductive and Urinary Physiology; Toxicology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ganesan, S. (2014). Cellular and molecular mechanisms of chemical-induced ovarian toxicity. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/14149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ganesan, Shanthi. “Cellular and molecular mechanisms of chemical-induced ovarian toxicity.” 2014. Thesis, Iowa State University. Accessed January 18, 2021. https://lib.dr.iastate.edu/etd/14149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ganesan, Shanthi. “Cellular and molecular mechanisms of chemical-induced ovarian toxicity.” 2014. Web. 18 Jan 2021.

Vancouver:

Ganesan S. Cellular and molecular mechanisms of chemical-induced ovarian toxicity. [Internet] [Thesis]. Iowa State University; 2014. [cited 2021 Jan 18]. Available from: https://lib.dr.iastate.edu/etd/14149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ganesan S. Cellular and molecular mechanisms of chemical-induced ovarian toxicity. [Thesis]. Iowa State University; 2014. Available from: https://lib.dr.iastate.edu/etd/14149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

13. Calisi, Rebecca Marie. Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions.

Degree: Integrative Biology, 2010, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/5wh4r17n

► Stress is a known inhibitor of reproductive function and its associated behaviors. How and why stress acts to influence reproduction have been intensely studied and… (more)

Subjects/Keywords: Biology, Neuroscience; Biology, Animal Physiology; birds; GnIH; gonadotropin inhibitory hormone; reproduction; reproductive endocrinology; stress

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Calisi, R. M. (2010). Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/5wh4r17n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Calisi, Rebecca Marie. “Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions.” 2010. Thesis, University of California – Berkeley. Accessed January 18, 2021. http://www.escholarship.org/uc/item/5wh4r17n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Calisi, Rebecca Marie. “Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions.” 2010. Web. 18 Jan 2021.

Vancouver:

Calisi RM. Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions. [Internet] [Thesis]. University of California – Berkeley; 2010. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/5wh4r17n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Calisi RM. Gonadotropin Inhibitory Hormone: New Insights into the Neuroendocrinology of Stress and Social Conditions. [Thesis]. University of California – Berkeley; 2010. Available from: http://www.escholarship.org/uc/item/5wh4r17n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Furtado, Priscila Viau. Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires).

Degree: PhD, Reprodução Animal, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10131/tde-11042008-092435/ ;

►

O objetivo deste trabalho foi avaliar de maneira detalhada e sistemática os perfis hormonais sanguíneos, fecais, urinários e salivares das progestinas e estrógenos durante o… (more)

▼

O objetivo deste trabalho foi avaliar de maneira detalhada e sistemática os perfis hormonais sanguíneos, fecais, urinários e salivares das progestinas e estrógenos durante o ciclo estral induzido de ovinos. Foram colhidas amostras diárias durante um período de 60 dias de sete fêmeas adultas (n=8) saudáveis e sexualmente maduras. Antes do início da fase de colheita das amostras, todos os animais foram submetidos ao protocolo de tratamento hormonal para indução e sincronização do cio durante dozes dias. O primeiro ciclo ovariano de cada animal desse experimento, detectado logo após a indução do cio foi descartado e seus valores não foram utilizados nas análises hormonais, pois poderiam estar sob o efeito dos hormônios exógenos. A concentração dos progestágenos foi determinada pelas técnicas analíticas de Radioimunoensaio (RIE) e Enzimaimunoensaio (EIE) e os estrógenos por RIE. Houve correlações entre as concentrações de progesterona medidas nas matrizes sérica e fecal, sérica e salivar, fecal e salivar (r=0,90, p<0,0001; r=0,90, p<0,0001; r=0,92, p<0,0001, respectivamente) durante os ciclos estrais observados (n=15). Obtivemos correlação (r=0,74, p<0,0001) entre as concentrações dos estrógenos quantificados nas matrizes sérica e fecal, mas não entre estas concentrações e aquelas medidas na matriz salivar. Não obtivemos nenhuma correlação entre as concentrações medidas na matriz urinária com as quantificadas nas outras matrizes para nenhum dos hormônios estudados. Obtivemos correlação entre as concentrações de progesterona medidas na matriz fecal pelos métodos de RIE e EIE (r=0,78, p<0,0001) e também na matriz salivar pelos dois métodos empregados (r=0,81, p<0,0001). Os resultados do presente experimento indicam que os imunoensaios utilizados podem ser utilizados para a avaliação das concentrações de progestágenos nas matrizes fecal e salivar durante o ciclo estral em ovinos.

The aim of the present work was evaluate the hormonal profiles of progestins and estrogens in blood, feces, urine and saliva during the induced estral cycle in ovine. Samples were collected daily a 60-day period from eight adult (n=8) cycling ewes. The animals were previously submitted to a protocol of estrus induction and synchronization for twelve days. In order to avoid the effect of exogenous hormones, the first cycle immediately after the synchronization was not considered for hormonal analysis. Progestagen concentrations were quantified by two analytical techniques, radioimmunoassay (RIA) and enzyme immunoassay (EIA). Estrogen concentrations were assessed by radioimmunoassay. Correlations in progesterone concentrations were found to be significant for serum and feces, serum and saliva and feces and saliva (r=0.90, p<0.0001; r=0.90, p<0.0001; r=0.92, p<0.0001, respectively) during the estrous cycles (n=15). Estrogen concentrations in the serum and feces were also positively correlated (r=0.74, p<0.0001). Salivary concentrations of estrogens were not correlated with fecal or serum concentrations of the same hormone. No correlation was found…

Advisors/Committee Members: Oliveira, Claudio Alvarenga de.

Subjects/Keywords: Animals estrous cycle; Ciclo estral animal; Endocrinolgia; Endocrinology; Esteróides; Immunoassay; Imunoensaio; Ovine; Ovinos; Steroids

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Furtado, P. V. (2007). Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires). (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10131/tde-11042008-092435/ ;

Chicago Manual of Style (16^th Edition):

Furtado, Priscila Viau. “Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires).” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-11042008-092435/ ;.

MLA Handbook (7^th Edition):

Furtado, Priscila Viau. “Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires).” 2007. Web. 18 Jan 2021.

Vancouver:

Furtado PV. Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires). [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10131/tde-11042008-092435/ ;.

Council of Science Editors:

Furtado PV. Perfil analítico de estrógenos e progestinas em diferentes matrizes biológicas na espécie ovina (Ovis aires). [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/10/10131/tde-11042008-092435/ ;

Cornell University

15. Krumm, Christopher Steven. Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse.

Degree: PhD, Animal Science, 2017, Cornell University

URL: http://hdl.handle.net/1813/47862

► The first part of this dissertation assessed factors regulating the insulin sensitizing hormone adiponectin in dairy cows. Plasma adiponectin is reduced during the transition from… (more)

▼ The first part of this dissertation assessed factors regulating the insulin sensitizing hormone adiponectin in dairy cows. Plasma adiponectin is reduced during the transition from late pregnancy (LP) to early lactation (EL) in parallel with rapid changes in the plasma concentration of metabolic hormones [i.e. insulin, leptin, and growth hormone (GH)] and non-esterified fatty acids (NEFA). The first study of this dissertation showed that none of these factors contribute to the regulation of plasma adiponectin. The second study tested the possibility that altered endoplasmic reticulum (ER) chaperone expression is involved. This was motivated by the following observations: 1) Plasma adiponectin variation in transition dairy cows occurs in absence of changes in adiponectin mRNA. 2) In rodents, the master regulator of ER homeostasis x-box binding protein 1 (Xbp1) regulates adiponectin production by increasing ER chaperone expression. We showed that Xbp1 expression decreased from LP to EL in the dairy cow. Using a primary bovine adipocyte system, overexpression of Xbp1 had no effect on adiponectin, despite increasing expression of several ER chaperone proteins. The factors regulating plasma adiponectin in the transition dairy cow remain unknown. The second part of this dissertation addressed the role of sel-1 suppressor of lin-12-like protein (Sel1l) in lipid metabolism. Sel1l is a critical component of the endoplasmic reticulum associated degradation (ERAD) system required for translocation and degradation of misfolded or aggregated proteins. Adipose-specific deletion of Sel1l in mice has implicated an ERAD-independent role for Sel1l in lipid metabolism. To this end, we generated liver-specific Sel1l knockout mice (ΔSel1lLiver) to assess whether Sel1l plays a similar role in lipid homeostasis in liver. Lipid metabolism was nearly normal in ΔSel1lLiver mice fed chow or high fat diet. ΔSel1lLiver mice on an atherogenic diet (AD) showed increased hyperlipidemia, hypercholesterolemia, liver damage, and occasional death compared to wildtype (WT) mice. This phenotype was associated with increased 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) and decreased low-density lipoprotein receptor (Ldlr) in liver of ΔSel1lLiver mice. Together, our results reveal a previously unknown role for Sel1l in lipid homeostasis in liver, but further studies are needed to elucidate the mechanism. Advisors/Committee Members: Boisclair, Yves R (chair), Lujan, Marla E. (committee member), Van Amburgh, Michael E (committee member), Weiss, Robert S. (committee member).

Subjects/Keywords: Endocrinology; Biology; Adiponectin; endoplasmic reticulum stress; Metabolism; Sel1L; Transition Dairy Cow; Animal sciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krumm, C. S. (2017). Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/47862

Chicago Manual of Style (16^th Edition):

Krumm, Christopher Steven. “Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse.” 2017. Doctoral Dissertation, Cornell University. Accessed January 18, 2021. http://hdl.handle.net/1813/47862.

MLA Handbook (7^th Edition):

Krumm, Christopher Steven. “Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse.” 2017. Web. 18 Jan 2021.

Vancouver:

Krumm CS. Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse. [Internet] [Doctoral dissertation]. Cornell University; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1813/47862.

Council of Science Editors:

Krumm CS. Tales of Metabolic Regulation: Adiponectin in the Cow and Sel1L in the Mouse. [Doctoral Dissertation]. Cornell University; 2017. Available from: http://hdl.handle.net/1813/47862

University of California – San Francisco

16. Faguet, Josh. The role of neuropeptide signaling in C. elegans food sensation and social behavior.

Degree: Biomedical Sciences, 2014, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/27b1x0v0

► Neuropeptides are a diverse and ancient class of signaling molecule. Many act as neuromodulators, incorporating flexibility into the fixed circuits of the nervous system. In… (more)

Subjects/Keywords: Neurosciences; Endocrinology; Animal behavior; Food; HEN-1; Hormone; Neuropeptide; NPR-1; Social behavior

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Faguet, J. (2014). The role of neuropeptide signaling in C. elegans food sensation and social behavior. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/27b1x0v0

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Faguet, Josh. “The role of neuropeptide signaling in C. elegans food sensation and social behavior.” 2014. Thesis, University of California – San Francisco. Accessed January 18, 2021. http://www.escholarship.org/uc/item/27b1x0v0.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Faguet, Josh. “The role of neuropeptide signaling in C. elegans food sensation and social behavior.” 2014. Web. 18 Jan 2021.

Vancouver:

Faguet J. The role of neuropeptide signaling in C. elegans food sensation and social behavior. [Internet] [Thesis]. University of California – San Francisco; 2014. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/27b1x0v0.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Faguet J. The role of neuropeptide signaling in C. elegans food sensation and social behavior. [Thesis]. University of California – San Francisco; 2014. Available from: http://www.escholarship.org/uc/item/27b1x0v0

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of North Carolina

17. Garcia, Nicholas. Leptin's Effects on Amphibian Sexual Behavior.

Degree: Biology, 2014, University of North Carolina

URL: https://cdr.lib.unc.edu/record/uuid:e4aaf605-d7d8-4f59-954a-d9eb207e4bb9

► Mate choice is an essential decision for sexually reproducing animals. This decision is influenced by a number of dynamic cues including an animal's internal physiology.… (more)

Subjects/Keywords: Biology; Animal behavior; Endocrinology; College of Arts and Sciences; Department of Biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcia, N. (2014). Leptin's Effects on Amphibian Sexual Behavior. (Thesis). University of North Carolina. Retrieved from https://cdr.lib.unc.edu/record/uuid:e4aaf605-d7d8-4f59-954a-d9eb207e4bb9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garcia, Nicholas. “Leptin's Effects on Amphibian Sexual Behavior.” 2014. Thesis, University of North Carolina. Accessed January 18, 2021. https://cdr.lib.unc.edu/record/uuid:e4aaf605-d7d8-4f59-954a-d9eb207e4bb9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garcia, Nicholas. “Leptin's Effects on Amphibian Sexual Behavior.” 2014. Web. 18 Jan 2021.

Vancouver:

Garcia N. Leptin's Effects on Amphibian Sexual Behavior. [Internet] [Thesis]. University of North Carolina; 2014. [cited 2021 Jan 18]. Available from: https://cdr.lib.unc.edu/record/uuid:e4aaf605-d7d8-4f59-954a-d9eb207e4bb9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcia N. Leptin's Effects on Amphibian Sexual Behavior. [Thesis]. University of North Carolina; 2014. Available from: https://cdr.lib.unc.edu/record/uuid:e4aaf605-d7d8-4f59-954a-d9eb207e4bb9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Arizona State University

18. Mennenga, Sarah Elaine. On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan.

Degree: Psychology, 2015, Arizona State University

URL: http://repository.asu.edu/items/36474

► Women are exposed to numerous endogenous and exogenous hormones across the lifespan. In the last several decades, the prescription of novel hormonal contraceptives and hormone… (more)

▼ Women are exposed to numerous endogenous and exogenous hormones across the lifespan. In the last several decades, the prescription of novel hormonal contraceptives and hormone therapies (HTs) have resulted in aging women that have a unique hormone exposure history; little is known about the impact of these hormone exposures on short- and long- term brain health. The goal of my dissertation was to understand how lifetime hormone exposures shape the female cognitive phenotype using several innovative approaches, including a new human spatial working memory task, the human radial arm maze (HRAM), and several rodent menopause models with variants of clinically used hormone treatments. Using the HRAM (chapter 2) and established human neuropsychological tests, I determined males outperformed females with high endogenous or exogenous estrogen levels on visuospatial tasks and the spatial working memory HRAM (chapter 3). Evaluating the synthetic estrogen in contraceptives, ethinyl estradiol (EE), I found a high EE dose impaired spatial working memory in ovariectomized (Ovx) rats, medium and high EE doses reduced choline-acetyltransferace-immunoreactive neuron population estimates in the basal forebrain following Ovx (chapter 4), and low EE impaired spatial cognition in ovary-intact rats (chapter 5). Assessing the impact of several clinically-used HTs, I identified a window of opportunity around ovarian follicular depletion outside of which the HT conjugated equine estrogens (CEE) was detrimental to spatial memory (chapter 6), as well as therapeutic potentials for synthetic contraceptive hormones (chapter 9) and bioidentical estradiol (chapter 7) during and after the transition to menopause. Chapter 6 and 7 findings, that estradiol and Ovx benefitted cognition after the menopause transition, but CEE did not, are perhaps due to the negative impact of ovarian-produced, androstenedione-derived estrone; indeed, blocking androstenedione’s conversion to estrone prevented its cognitive impairments (chapter 8). Finally, I determined that EE combined with the popular progestin levonorgestrel benefited spatial memory during the transition to menopause, a profile not seen with estradiol, levonorgestrel, or EE alone (chapter 9). This work identifies several cognitively safe, and enhancing, hormonal treatment options at different time points throughout female aging, revealing promising avenues toward optimizing female health.

Subjects/Keywords: Behavioral sciences; Endocrinology; Neurosciences; Animal Behavior; Estrogen; Hormonal Contraceptive; Hormone Therapy; Neuroendocrinology; Spatial Memory

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mennenga, S. E. (2015). On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/36474

Chicago Manual of Style (16^th Edition):

Mennenga, Sarah Elaine. “On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan.” 2015. Doctoral Dissertation, Arizona State University. Accessed January 18, 2021. http://repository.asu.edu/items/36474.

MLA Handbook (7^th Edition):

Mennenga, Sarah Elaine. “On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan.” 2015. Web. 18 Jan 2021.

Vancouver:

Mennenga SE. On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan. [Internet] [Doctoral dissertation]. Arizona State University; 2015. [cited 2021 Jan 18]. Available from: http://repository.asu.edu/items/36474.

Council of Science Editors:

Mennenga SE. On the Cognitive Impact of Endogenous and Exogenous Hormone Exposures Across the Lifespan. [Doctoral Dissertation]. Arizona State University; 2015. Available from: http://repository.asu.edu/items/36474

Arizona State University

19. Gao, Sisi. The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow.

Degree: Biology, 2017, Arizona State University

URL: http://repository.asu.edu/items/44130

► In wild birds, the stress response can inhibit the activity of the innate immune system, which serves as the first line of defense against pathogens.… (more)

▼ In wild birds, the stress response can inhibit the activity of the innate immune system, which serves as the first line of defense against pathogens. By elucidating the mechanisms which regulate the interaction between stress and innate immunity, researchers may be able to predict when birds experience increased susceptibility to infections and can target specific mediators to mitigate stress-induced suppression of innate immune activity. Such elucidation is especially important for urban birds, such as the House Sparrow (Passer domesticus), because these birds experience higher pathogen prevalence and transmission when compared to birds in rural regions. I investigated the role of corticosterone (CORT) in stress-induced suppression of two measures of innate immune activity (complement- and natural antibody-mediated activity) in male House Sparrows. Corticosterone, the primary avian glucocorticoid, is elevated during the stress response and high levels of this hormone induce effects through the activation of cytosolic and membrane-bound glucocorticoid receptors (GR). My results demonstrate that CORT is necessary and sufficient for stress-induced suppression of complement-mediated activity, and that this relationship is consistent between years. Corticosterone, however, does not inhibit complement-mediated activity through cytosolic GR, and additional research is needed to confirm the involvement of membrane-bound GR. The role of CORT in stress-induced inhibition of natural antibody-mediated activity, however, remains puzzling. Stress-induced elevation of CORT can suppress natural antibody-mediated activity through the activation of cytosolic GR, but the necessity of this mechanism varies inter-annually. In other words, both CORT-dependent and CORT-independent mechanisms may inhibit natural antibody-mediated activity during stress in certain years, but the causes of this inter-annual variation are not known. Previous studies have indicated that changes in the pathogen environment or food availability can alter regulation of innate immunity, but further research is needed to test these hypotheses. Overall, my dissertation demonstrates that stress inhibits innate immunity through several mechanisms, but environmental pressures may influence this inhibitory relationship.

Subjects/Keywords: Endocrinology; Immunology; Animal sciences; Corticosterone; House Sparrow; Innate Immunity; Mitotane; RU486; Stress

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gao, S. (2017). The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/44130

Chicago Manual of Style (16^th Edition):

Gao, Sisi. “The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow.” 2017. Doctoral Dissertation, Arizona State University. Accessed January 18, 2021. http://repository.asu.edu/items/44130.

MLA Handbook (7^th Edition):

Gao, Sisi. “The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow.” 2017. Web. 18 Jan 2021.

Vancouver:

Gao S. The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow. [Internet] [Doctoral dissertation]. Arizona State University; 2017. [cited 2021 Jan 18]. Available from: http://repository.asu.edu/items/44130.

Council of Science Editors:

Gao S. The Role of Corticosterone in Stress-induced Suppression of Innate Immunity in the Male House Sparrow. [Doctoral Dissertation]. Arizona State University; 2017. Available from: http://repository.asu.edu/items/44130

Arizona State University

20. Fokidis, Haralambos Bobby. From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds.

Degree: PhD, Biology, 2010, Arizona State University

URL: http://repository.asu.edu/items/8631

► The impact of urbanization on wildlife is becoming an important topic in conservation. However little is known concerning the proximate mechanisms involved which enable some… (more)

Subjects/Keywords: Biology, Animal Physiology; Endocrinology; Conservation Biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fokidis, H. B. (2010). From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/8631

Chicago Manual of Style (16^th Edition):

Fokidis, Haralambos Bobby. “From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds.” 2010. Doctoral Dissertation, Arizona State University. Accessed January 18, 2021. http://repository.asu.edu/items/8631.

MLA Handbook (7^th Edition):

Fokidis, Haralambos Bobby. “From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds.” 2010. Web. 18 Jan 2021.

Vancouver:

Fokidis HB. From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds. [Internet] [Doctoral dissertation]. Arizona State University; 2010. [cited 2021 Jan 18]. Available from: http://repository.asu.edu/items/8631.

Council of Science Editors:

Fokidis HB. From The Brain To The Barrio: Energy And Stress Interact To Facilitate The Urbanization Of Sonoran Desert Birds. [Doctoral Dissertation]. Arizona State University; 2010. Available from: http://repository.asu.edu/items/8631

21. Li, Qing. RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES.

Degree: 2019, University of Kentucky

URL: https://uknowledge.uky.edu/animalsci_etds/99

► The first goal of the current research was to determine whether gene expression profiles differed between whole pituitaries of growing beef steers grazing pastures containing… (more)

▼ The first goal of the current research was to determine whether gene expression profiles differed between whole pituitaries of growing beef steers grazing pastures containing high (HE) or low (LE) amounts of toxic endophyte-infected tall fescue. The global (microarray analysis) and selected targeted (RT-PCR) mRNA expression patterns of pituitaries collected from beef steers (BW = 266 ± 15.5 kg) that had been randomly assigned to undergo summer-long grazing (89 to 105 d) of either HE (0.52 ppm ergot alkaloids) or LE (< 0.03 ppm ergot alkaloids) pastures were compared. Gene expression data were subjected to one-way ANOVA. The pituitaries of HE steers had 542 differentially expressed genes, and the pattern of altered gene expression was dependent on treatment. Targeted RT-PCR analysis corroborated these findings, including decreased expression of DRD2, PRL, POU1F1, GAL, and VIP and that of POMC and PCSK1, respectively. Canonical pathway analysis (Integrated Pathway Analysis, IPA) identified HE-dependent alteration in signaling of additional pituitary-derived hormones, including growth hormone and GnRH. In conclusion, consumption of endophyte-infected tall fescue alters the pituitary transcriptome profiles of steers in a manner consistent with their negatively affected physiological parameters. The second goal of this project was to test the hypothesis that sodium selenite (ISe), SEL-PLEX (OSe), vs. a 1:1 blend (MIX) of ISe and OSe in a basal vitamin-mineral (VM) mix would differentially alter pituitary transcriptome profiles in growing beef steers (BW = 183 ± 34 kg) commonly grazing an endophyte-infected tall fescue (HE) pasture. Steers were randomly selected from herds of fall-calving cows grazing HE pasture and consuming VM mixes that contained 35 ppm Se as either ISe, OSe, or MIX forms. Steers were weaned, depleted of Se for 98 d, and subjected to summer-long common grazing of a 10.1 ha HE pasture containing 0.51 ppm ergot alkaloids. Steers were assigned (n = 8) to the same Se-form treatments on which they were raised. Selenium treatments were administered by daily top-dressing 85 g of VM mix onto 0.23 kg soyhulls, using in-pasture Calan gates. Pituitaries were collected at slaughter and changes in global (microarray) and selected (RT-PCR) mRNA expression patterns determined. The effects of Se treatment on relative gene expression were subjected to one-way ANOVA. The form of Se affected the expression of 542 annotated genes. Integrated Pathway Analysis found a canonical pathway network between prolactin and POMC/ACTH/ α-MSH synthesis-related proteins, and that mitochondrial dysfunction was a top-affected canonical pathway. Targeted RT-PCR analysis found that the relative abundance of mRNA encoding prolactin and POMC/ACTH/ α-MSH synthesis-related proteins was affected by the form of Se, as were mitochondrial dysfunction-related proteins OSe steers appeared to have a greater prolactin synthesis capacity vs. ISe steers through decreased dopamine receptor D2 signaling, whereas MIX steers had a greater prolactin synthesis…

Subjects/Keywords: Bovine pituitary; Ergot alkaloid; Fescue toxicosis; Prolactin; Selenium; Selenoprotein; Animal Sciences; Beef Science; Endocrinology

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, Q. (2019). RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/animalsci_etds/99

Chicago Manual of Style (16^th Edition):

Li, Qing. “RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES.” 2019. Doctoral Dissertation, University of Kentucky. Accessed January 18, 2021. https://uknowledge.uky.edu/animalsci_etds/99.

MLA Handbook (7^th Edition):

Li, Qing. “RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES.” 2019. Web. 18 Jan 2021.

Vancouver:

Li Q. RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES. [Internet] [Doctoral dissertation]. University of Kentucky; 2019. [cited 2021 Jan 18]. Available from: https://uknowledge.uky.edu/animalsci_etds/99.

Council of Science Editors:

Li Q. RESPONSES OF BOVINE PITUITARY TRANSCRIPTOME PROFILES TO CONSUMPTION OF TOXIC TALL FESCUE AND FORMS OF SELENIUM IN VITAMIN-MINERAL MIXES. [Doctoral Dissertation]. University of Kentucky; 2019. Available from: https://uknowledge.uky.edu/animalsci_etds/99

Michigan State University

22. Martins, João Paulo Nascimento. Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows.

Degree: 2016, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:4125

►

Thesis Ph. D. Michigan State University. Animal Science 2016

Reproductive performance of lactating dairy cows is a key profit generator for dairy producers. During the… (more)

▼

Thesis Ph. D. Michigan State University. Animal Science 2016

Reproductive performance of lactating dairy cows is a key profit generator for dairy producers. During the last 6 decades, as milk production has increased significantly, pregnancy per artificial insemination (P/AI) of lactating dairy cows has decreased. Moreover, high milk production is associated with the increased metabolic clearance rate of progesterone (P4) and estradiol due to greater feed intake and greater blood flow through the liver. Previous data from our laboratory and others have indicated that cows with the greatest circulating concentrations of P4 during ovulatory follicle development had the greatest P/AI. Furthermore, timed-AI programs that control follicle and corpus luteum (CL) development increase circulating concentrations of P4 during the growth of the ovulatory follicle and synchronize ovulation, and improve fertility of lactating dairy cows following timed-AI. The mechanism involved on the effects of levels of P4 during growth of the ovulatory follicle on fertility remains unclear. Our overall hypothesis of this dissertation is that treatments that increase serum concentrations of P4 during the growth of the ovulatory follicle increase P/AI and reduce pregnancy losses in lactating dairy cows. The three main objectives are: (1) determine the effect of three fertility treatments on serum concentrations of P4 during the growth of the ovulatory follicle and P/AI of lactating dairy cows; (2) develop a simpler fertility treatment for dairy operations limited by labor or other logistical constraints that cannot use currently fertility treatments; and (3) determine the effect of high vs. low P4 during ovulatory follicle development on fertility of lactating dairy cows. Research in Chapter 3 focused on the comparisons of fertility treatments that increase the percentage of cows with an accessory CL during the growth of the ovulatory follicle. We hypothesized that fertility treatments that use pre-synchronization with PGF2α and GnRH would increase: percentage of cows with an accessory CL at time of ovulatory follicle development, circulating levels of P4 and P/AI compared to pre-synchronization with only PGF2α. Results indicated that fertility treatments with pre-synchronization with GnRH were able to increase percentage of cows with accessory CL; However, P/AI was similar to a pre-synchronization with only PGF2α. Interestingly, enhancing P4 during growth of the ovulatory follicle was associated with enhanced PAI of in a large number of lactating dairy cows (~2500). In Chapters 4 and 5 experiments, we hypothesized that combining PGF2α and GnRH (PG+G) in a pre- synchronization strategy one week before Ovsynch would result in similar P/AI compared to other fertility treatments. Results indicated that our simpler pre-synchronization program had similar outcomes compared to fertility programs. Thus, it may offer a reasonable alternative to more complex fertility programs to enhance P/AI. The hypothesis of Chapter 7 study was that reduced…

Advisors/Committee Members: Pursley, James Richard, Smith, George W, Cibelli, Jose, Knott, Jason, Erskine, Ronald, Fazleabas, Asgi.

Subjects/Keywords: Dairy cattle – Reproduction; Dairy cattle – Fertility; Corpus luteum; Progestational hormones; Animal sciences; Physiology; Endocrinology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martins, J. P. N. (2016). Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martins, João Paulo Nascimento. “Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows.” 2016. Thesis, Michigan State University. Accessed January 18, 2021. http://etd.lib.msu.edu/islandora/object/etd:4125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martins, João Paulo Nascimento. “Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows.” 2016. Web. 18 Jan 2021.

Vancouver:

Martins JPN. Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows. [Internet] [Thesis]. Michigan State University; 2016. [cited 2021 Jan 18]. Available from: http://etd.lib.msu.edu/islandora/object/etd:4125.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martins JPN. Advancing the pharmacological control of ovarian development to enhance fertility of lactating dairy cows. [Thesis]. Michigan State University; 2016. Available from: http://etd.lib.msu.edu/islandora/object/etd:4125

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

23. Stein, Gisele Guiomara. Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo.

Degree: 2014, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/103490

►

Durante as últimas duas décadas, as técnicas de análise de esteroides fecais têm sido utilizadas para pesquisa em endocrinologia reprodutiva em diversas espécies animais silvestres… (more)

▼

Durante as últimas duas décadas, as técnicas de análise de esteroides fecais têm sido utilizadas para pesquisa em endocrinologia reprodutiva em diversas espécies animais silvestres de vida livre, ou cativeiro. O presente estudo propõe a validação da técnica do ensaio imunoenzimático antiprogestinas CL425 e antiandrógenos R156/7 fecais em papagaio-de-peito-roxo (Amazona vinacea). Objetiva-se descrever os perfis endócrinos anuais dos esteroides sexuais urofecais em Amazona vinacea com potencial aplicação para o aprimoramento do manejo reprodutivo da espécie. Foram utilizados 10 casais adultos da espécie Amazona vinacea mantidos em viveiros suspensos, em Lomba Grande, Rio Grande do Sul, Brasil. As excretas foram coletadas duas vezes por semana, entre maio de 2012 e maio de 2013. O monitoramento da atividade gonadal foi feito por mensuração de metabólitos de andrógenos nas excretas dos machos e progestágenos, nas de fêmeas. Foram coletadas amostras frescas de excretas, consistentemente, entre 12h00min e 16h00min e mantidas congeladas até o processamento. O perfil anual de andrógenos nas excretas de machos de A. vinacea apresentou médias mensais variáveis de 25,9 ng/g, em janeiro até 125,7 ng/g, em setembro. O perfil anual de progestinas nas excretas de fêmeas A. vinacea, as médias mensais variaram de 2,76 ng/g, em dezembro até 45,7 ng/g, em setembro. Os perfis reprodutivos apresentaram variação na atividade hormonal, durante a fase reprodutiva. Porém, comparando-se casais reprodutores com não-reprodutores, observa-se que os níveis de progestágenos não diferiram significativamente entre fêmeas que fizeram postura e aquelas que não fizeram. Entretanto, os níveis de andrógenos diferiram significativamente entre reprodutores e não-reprodutores. Diferenças hormonais foram observadas nas diferentes estações anuais, tanto nos machos, quanto nas fêmeas. Dados metereológicos de temperatura e insolação demostraram correlação negativa com os perfís anuais de progestágenos. A utilização da metodologia aqui mencionada demonstrou aplicabilidade, praticidade e segurança como ferramenta para o estudo da fisiologia e do manejo reprodutivos de Amazona vinacea.

During the last two decades, the techniques of analysis of fecal steroids have been applied for studying reproductive profiles in many species of captive wild and free living wild animals. The advantages of this methodology are widely understood. This study aimed to validate the anti- CL425 progestin and anti-R156/7 androgen enzyme immunoassay in fecal samples from parrot-breasted-purple (Amazon vinacea). This communication describes the annual endocrine profiles of urofecal sex steroids in Amazona vinacea with potential application for improving the species reproductive management. In total, 10 adult A. vinacea pairs kept in suspended aviaries in southern Brazil were studied. Excreta samples were collected twice weekly between May 2012 and May 2013. Gonadal activity was monitored by measurement of androgen and progestin metabolites in excreta of birds. Fresh excreta samples…

Advisors/Committee Members: Diaz Gonzalez, Félix Hilário.

Subjects/Keywords: Hematologia veterinaria; Endocrinology; Bioquimica veterinaria; Noninvasive monitoring; Psittacines; Reproducao animal : Aves; Papagaio-de-peito-roxo Amazona vinacea; Metabolitos; Psitacídeos; Endocrinologia animal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stein, G. G. (2014). Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/103490

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stein, Gisele Guiomara. “Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo.” 2014. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021. http://hdl.handle.net/10183/103490.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stein, Gisele Guiomara. “Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo.” 2014. Web. 18 Jan 2021.

Vancouver:

Stein GG. Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10183/103490.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stein GG. Determinação do ciclo reprodutivo de papagaio-de-peito-roxo Amazona vinacea (kuhl, 1820) (aves: psittacidae) por meio de mensuração de metabólitos hormonais utilizando um método não invasivo. [Thesis]. Universidade do Rio Grande do Sul; 2014. Available from: http://hdl.handle.net/10183/103490

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Chelini, Marie Odile Monier. Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus).

Degree: PhD, Psicologia Experimental, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/47/47132/tde-22032010-110353/ ;

►

A flexibilidade da socialidade presente em muitas espécies sugere que muitos dos traços comportamentais e fisiológicos presentes em grupos sociais complexos possam existir em estado… (more)

▼

A flexibilidade da socialidade presente em muitas espécies sugere que muitos dos traços comportamentais e fisiológicos presentes em grupos sociais complexos possam existir em estado latente em indivíduos de espécies solitárias. Hierarquia de dominância e assimetria reprodutiva são traços característicos de espécies sociais. O hamster Sírio é um excelente modelo para o estudo do estresse social e dos seus efeitos fisiológicos e comportamentais. Na presente pesquisa foram enfocados os efeitos do alojamento em grupo antes e no início da gestação na fêmea de hamster Sírio. Investigou-se se o estresse social produz algum grau de assimetria reprodutiva nesta espécie solitária e se o sucesso reprodutivo e o comportamento materno das fêmeas variam em função do seu status social. Dois experimentos foram realizados envolvendo respectivamente 34 fêmeas de hamster criadas em grupo do desmame até o início do estudo e 76 fêmeas criadas isoladamente. Em cada experimento, um terço dos animais foram alojados em gaiolas individuais, enquanto pares de fêmeas desconhecidas umas das outras eram formados com os outros dois terços. O comportamento dos pares foi observado ao longo de 10 dias para determinar o status social de cada fêmea. Todas as fêmeas foram acasaladas neste período. Quatro dias após o parto, os filhotes foram contados, sexados e pesados e as ninhadas padronizadas a seis filhotes, três machos e três fêmeas. As mães e suas ninhadas foram observadas diariamente durante sessões de 40min e 13 categorias comportamentais foram registradas. No intuito de esclarecer os mecanismos fisiológicos subjacentes à relação entre estresse social e fertilidade, os níveis dos hormônios reprodutivos e dos glicocorticóides foram monitorados ao longo da gestação por métodos não-invasivos, previamente validados, de quantificação dos seus metabólitos nas fezes. Foi demonstrada, pela primeira vez, a adequação de um enzimaimunoensaio e de um conjunto diagnóstico comercial de radioimunoensaio para a quantificação respectiva dos metabólitos fecais de glicocorticóides em hamsters Sírios dos dois sexos e de testosterona no hamster Sírio macho, mas não da fêmea. As variações das concentrações de metabólitos fecais de progesterona, estrógenos e glicocorticóides, refletiram os perfis séricos descritos na literatura para hamsters gestantes. Os resultados mostram que quando fêmeas de hamster Sírio são alojadas individualmente após o desmame, sua fertilidade não é afetada pelo estresse social. Em contraste, quando as fêmeas são criadas em grupo, o estresse social tanto de isolamento como de subordinação a uma fêmea dominante induz um grau significante de assimetria reprodutiva, traço característico de espécies sociais que criam seus filhotes em comunidade. A manutenção de hamsters cativos adultos em grupos parece despertar traços comportamentais e fisiológicos presentes em grupos sociais complexos e que se encontram em estado latente nesta espécie solitária. A socialidade parece flexível no hamster e modulada pelas condições ecológicas.

The flexibility of…

Advisors/Committee Members: Felicio, Luciano Freitas, Otta, Emma.

Subjects/Keywords: Animal maternal behavior; Animal social behavior; Comportamento materno (animal); Comportamento social (animal); Endocrinologia; Endocrinology; Hamsters; Hamsters; Reprodução sexual; Sexual reproduction; Stress; Stress

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chelini, M. O. M. (2010). Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus). (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/47/47132/tde-22032010-110353/ ;

Chicago Manual of Style (16^th Edition):

Chelini, Marie Odile Monier. “Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus).” 2010. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-22032010-110353/ ;.

MLA Handbook (7^th Edition):

Chelini, Marie Odile Monier. “Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus).” 2010. Web. 18 Jan 2021.

Vancouver:

Chelini MOM. Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus). [Internet] [Doctoral dissertation]. University of São Paulo; 2010. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/47/47132/tde-22032010-110353/ ;.

Council of Science Editors:

Chelini MOM. Efeito do estresse social sobre o comportamento materno do hamster Sírio (Mesocricetus auratus). [Doctoral Dissertation]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/47/47132/tde-22032010-110353/ ;

Iowa State University

25. Sanz Fernández, María Victoria. The effects of heat stress on energetic metabolism and insulin homeostasis.

Degree: 2014, Iowa State University

URL: https://lib.dr.iastate.edu/etd/14292

► Heat stress (HS) is a major environmental hazard for human health and animal agriculture. Changes in metabolism and specifically altered insulin action appear to be… (more)

▼ Heat stress (HS) is a major environmental hazard for human health and animal agriculture. Changes in metabolism and specifically altered insulin action appear to be critical for the adaptation and ultimately survival to a severe heat load. However, our knowledge of the physiological and metabolic consequences of HS is woefully insufficient. Understanding the biology of HS is critical in order to develop treatment protocols and mitigation strategies against its deleterious effects on both humans and livestock. Interestingly, HS elicits a metabolic profile that somewhat resembles models of endotoxemia/sepsis. Moreover, HS negatively affects intestinal health and the subsequent increase in the permeability to luminal pro-inflammatory molecules might be the link between both models. Therefore, alleviating the effects of HS on the intestinal barrier function may have the potential to prevent or ameliorate its impact on animal health and productivity. Studies conducted for this dissertation utilized sus scrofa as the model, due to the pig's relevance in both animal agriculture and the biomedical field. Study 1 (chapter 2) was conducted to determine the temporal effects of HS on basal and stimulated metabolism. Results indicated that HS decreases both basal and adrenergic-induced adipose tissue mobilization. Heat stress increased basal insulin secretion and decreased circulating thyroid hormones. Early heat exposure decreased glucose disposal in response to a glucose tolerance test, which might suggest increased whole body insulin resistance. However when considering the glucose and insulin responses together, HS pigs required less insulin compared to controls in order to dispose of a similar amount of glucose, which would actually indicate increased insulin sensitivity. Based on the conflicting results obtained in study 1 regarding insulin action, in study 2 (chapter 3) we aimed to define the effects of HS on whole-body insulin action. For this purpose we performed a hyperinsulinemic euglycemic clamp and concluded that, relative to controls, HS pigs required a greater rate of glucose infusion to maintain euglycemia. Further, molecular markers of insulin signaling prior and after insulin stimulation, suggested that the skeletal muscle is partially responsible for the increase in insulin-stimulated glucose uptake observed during HS. Heat stress has deleterious effects on intestinal health that may ultimately mediate its effects on energetic metabolism and productivity. Studies 3 and 4 (chapters 4 and 5) objectives were to establish the feasibility of dietary interventions in order to mitigate HS-induced intestinal barrier dysfunction. Previous research had demonstrated that dietary zinc and whey protein improve intestinal health in a variety of bowel disease models, which led us to hypothesize that their supplementation would alleviate the negative effects of HS on intestinal permeability. Results from these studies indicated that supplemental zinc improves aspects of small intestinal integrity during severe HS. In contrast,…

Subjects/Keywords: Nutritional Sciences; Carbohydrate metabolism; Heat stress; Insulin; Intestinal permeability; Lipid metabolism; Pig; Agriculture; Animal Sciences; Endocrinology; Endocrinology, Diabetes, and Metabolism; Environmental Sciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sanz Fernández, M. V. (2014). The effects of heat stress on energetic metabolism and insulin homeostasis. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/14292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanz Fernández, María Victoria. “The effects of heat stress on energetic metabolism and insulin homeostasis.” 2014. Thesis, Iowa State University. Accessed January 18, 2021. https://lib.dr.iastate.edu/etd/14292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanz Fernández, María Victoria. “The effects of heat stress on energetic metabolism and insulin homeostasis.” 2014. Web. 18 Jan 2021.

Vancouver:

Sanz Fernández MV. The effects of heat stress on energetic metabolism and insulin homeostasis. [Internet] [Thesis]. Iowa State University; 2014. [cited 2021 Jan 18]. Available from: https://lib.dr.iastate.edu/etd/14292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanz Fernández MV. The effects of heat stress on energetic metabolism and insulin homeostasis. [Thesis]. Iowa State University; 2014. Available from: https://lib.dr.iastate.edu/etd/14292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

26. Hey, Jane Pires. A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss.

Degree: 1994, Iowa State University

URL: https://lib.dr.iastate.edu/rtd/10609

► Eggs from many species of marine teleosts contain the thyroid hormones (THs), thyroxine (T[subscript]4) and 3,5,3[superscript]' triiodothyronine (T[subscript]3). Elevating striped bass egg T[subscript]3 concentration by… (more)

▼ Eggs from many species of marine teleosts contain the thyroid hormones (THs), thyroxine (T[subscript]4) and 3,5,3[superscript]' triiodothyronine (T[subscript]3). Elevating striped bass egg T[subscript]3 concentration by maternal injection increases larval growth and survival; T[subscript]3 may act during the critical period when larvae begin feeding. We investigated egg T[subscript]3 levels in walleye, whose life history is similar to striped bass, and compared walleye egg TH developmental changes with rainbow trout, a species with larger eggs, slower development and no critical period. Samples of eggs and larvae were frozen for hormone determination or fixed for thyroid histology at intervals up to 14 and 49 days posthatch (walleye and trout). THs were extracted and their concentrations determined by radioimmunoassay. Both walleye and trout eggs contained T[subscript]4 and T[subscript]3. Walleye egg T[subscript]4 concentration varied between hatcheries and individual females. Trout eggs contained more total THs than walleye, but TH concentrations were similar. Thyroid follicles appeared in both species at 5 days posthatch and are present during the walleye critical period. Neither species' larval hormone stores were depleted during development, but whether THs are present in sufficient amounts to optimize walleye survival during its critical period is not clear;Walleye have a life history similar to striped bass and both are difficult to culture. Therefore we investigated whether naturally occurring levels of these hormones in walleye eggs would relate to several parameters of larval performance in culture. Egg concentrations of T[subscript]3 correlated positively with gas bladder inflation rates and incidence of cannibalism in fry from six hatchery stocks. T[subscript]3 content per individual egg correlated positively with larval size at hatch, and T[subscript]4 concentration correlated positively with energy content of the egg;Immersing walleye fry in T[subscript]3 and T[subscript]4 (0,.01,.05,.10 ppm) under starving conditions increased both incidence of cannibalism and survival (time to 50 percent survival) in a dose related manner. T[subscript]3 was more effective than T[subscript]4 in these experiments;Thyroid hormones are potentially important regulators of walleye development and understanding their function may be important to achieving optimum culture conditions.

Subjects/Keywords: Zoology and genetics; Zoology (Endocrinology); Endocrinology; Agriculture; Animal Sciences; Aquaculture and Fisheries; Zoology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hey, J. P. (1994). A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/rtd/10609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hey, Jane Pires. “A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss.” 1994. Thesis, Iowa State University. Accessed January 18, 2021. https://lib.dr.iastate.edu/rtd/10609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hey, Jane Pires. “A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss.” 1994. Web. 18 Jan 2021.

Vancouver:

Hey JP. A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss. [Internet] [Thesis]. Iowa State University; 1994. [cited 2021 Jan 18]. Available from: https://lib.dr.iastate.edu/rtd/10609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hey JP. A study of thyroid hormones in eggs and larvae of walleye, Stizostedion vitreum, and rainbow trout, Oncorhynchus mykiss. [Thesis]. Iowa State University; 1994. Available from: https://lib.dr.iastate.edu/rtd/10609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

27. Sugianto, Nadine Adrianna. Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:8ca1b7fb-442a-4522-bbd0-744612814816 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791597

► Knowledge of reproductive adaptions and physiological mechanisms are essential in wildlife conservation as they impact species survival. As markers of bodily functions, hormones mirror reproductive… (more)

▼ Knowledge of reproductive adaptions and physiological mechanisms are essential in wildlife conservation as they impact species survival. As markers of bodily functions, hormones mirror reproductive activity and reveal baseline information including reproductive cycles and strategies, lifetime reproductive events such as puberty and senescence, as well as responses to ecological factors, which are all profound factors of wildlife population growth. In this thesis, the reproductive biology of the European badger (Meles meles) is examined by utilising endocrinological measures with complementary somatic and ecological data. Research chapter I establishes endocinological mechanisms of the flexible delayed implantation and superfoetation mating strategy, where number of additional mating seasons varies with population density across badger geographical range. Research chapter II demonstrates that despite hormone levels and external genitalia morphology (EGM) showing similar seasonal patterns, EGM in males is a reliable indicator of reproductive status only during the mating season, while in females EGM is a less precise proxy. Research chapter III reveals that asynchronous timing in attaining minimum body size, required for sexual maturity, results in two heterochronous phenotypes (early- and late- developers) in male cubs (less evident in females), while Research chapter IV showcases the decline in sex-steroid levels and somatic condition with age, leading to a post-reproductive lifespan (PRLS), while also showing two reproductive phenotypes (high and low hormone levels) in older individuals of both sexes. Research chapter V demonstrates that sexual selection is unlikely to be the driving force for sexual size dimorphism in badgers, but social and environmental factors, as well as endocrinological mechanisms, affecting juvenile diverging growth patterns and end body sizes are likely the primary physiological process of this phenomenon. Research chapter VI illustrates that ecological changes can be reflected in hormone levels and the regulation of these changes differs between sexes, likely linked to their respective reproductive strategies. Research chapter VII establishes that urinary metabolite measurement may reliably assess endocrine function in badgers as a non-invasive technique, especially in males. Collectively, these research chapters give a comprehensive understanding of the badger's reproductive processes and how it interacts with ecological factors.

Subjects/Keywords: Development; Senescence; European Badger; Puberty; Reproductive Strategies; Non-invasive Hormone Monitoring; Endocrinology; Reproductive biology; Animal Welfare; Ecology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sugianto, N. A. (2018). Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:8ca1b7fb-442a-4522-bbd0-744612814816 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791597

Chicago Manual of Style (16^th Edition):

Sugianto, Nadine Adrianna. “Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors.” 2018. Doctoral Dissertation, University of Oxford. Accessed January 18, 2021. http://ora.ox.ac.uk/objects/uuid:8ca1b7fb-442a-4522-bbd0-744612814816 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791597.

MLA Handbook (7^th Edition):

Sugianto, Nadine Adrianna. “Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors.” 2018. Web. 18 Jan 2021.

Vancouver:

Sugianto NA. Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Jan 18]. Available from: http://ora.ox.ac.uk/objects/uuid:8ca1b7fb-442a-4522-bbd0-744612814816 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791597.

Council of Science Editors:

Sugianto NA. Reproductive biology of the European badger (Meles meles) : endocrinological insights into lifetime reproductive events, strategies and cub development in response to ecological factors. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:8ca1b7fb-442a-4522-bbd0-744612814816 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791597

Eastern Illinois University

28. Barr, Mary Jo. The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats.

Degree: MS, 1973, Eastern Illinois University

URL: https://thekeep.eiu.edu/theses/3824

► The adrenal physiology of the albino rat was studied through the measurement of adrenal ascorbic acid levels. A cyclic phenomenon was observed which follows… (more)

Subjects/Keywords: Animal Experimentation and Research; Endocrinology; Veterinary Physiology; Zoology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barr, M. J. (1973). The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats. (Masters Thesis). Eastern Illinois University. Retrieved from https://thekeep.eiu.edu/theses/3824

Chicago Manual of Style (16^th Edition):

Barr, Mary Jo. “The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats.” 1973. Masters Thesis, Eastern Illinois University. Accessed January 18, 2021. https://thekeep.eiu.edu/theses/3824.

MLA Handbook (7^th Edition):

Barr, Mary Jo. “The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats.” 1973. Web. 18 Jan 2021.

Vancouver:

Barr MJ. The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats. [Internet] [Masters thesis]. Eastern Illinois University; 1973. [cited 2021 Jan 18]. Available from: https://thekeep.eiu.edu/theses/3824.

Council of Science Editors:

Barr MJ. The Effects of Crowding on the Diurnal Ascorbic Acid Levels of Albino Rats. [Masters Thesis]. Eastern Illinois University; 1973. Available from: https://thekeep.eiu.edu/theses/3824

Eastern Illinois University

29. Collier, Robert Joseph. The Effects of Acute Stress on Adrenal Ascorbic Acid Levels.

Degree: MS, 1973, Eastern Illinois University

URL: https://thekeep.eiu.edu/theses/3838

► The diurnal rhythm of adrenal ascorbic acid (DAR) displays an inverse relationship to the diurnal rhythm of circulating levels of plasma corticosteroids. Alloxan monohydrate,… (more)

Subjects/Keywords: Animal Experimentation and Research; Endocrinology; Veterinary Physiology; Zoology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Collier, R. J. (1973). The Effects of Acute Stress on Adrenal Ascorbic Acid Levels. (Masters Thesis). Eastern Illinois University. Retrieved from https://thekeep.eiu.edu/theses/3838

Chicago Manual of Style (16^th Edition):

Collier, Robert Joseph. “The Effects of Acute Stress on Adrenal Ascorbic Acid Levels.” 1973. Masters Thesis, Eastern Illinois University. Accessed January 18, 2021. https://thekeep.eiu.edu/theses/3838.

MLA Handbook (7^th Edition):

Collier, Robert Joseph. “The Effects of Acute Stress on Adrenal Ascorbic Acid Levels.” 1973. Web. 18 Jan 2021.

Vancouver:

Collier RJ. The Effects of Acute Stress on Adrenal Ascorbic Acid Levels. [Internet] [Masters thesis]. Eastern Illinois University; 1973. [cited 2021 Jan 18]. Available from: https://thekeep.eiu.edu/theses/3838.

Council of Science Editors:

Collier RJ. The Effects of Acute Stress on Adrenal Ascorbic Acid Levels. [Masters Thesis]. Eastern Illinois University; 1973. Available from: https://thekeep.eiu.edu/theses/3838

University of Arkansas

30. Devine, Thomas L. Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle.

Degree: MS, 2014, University of Arkansas

URL: https://scholarworks.uark.edu/etd/2161

► The objective of this thesis was to evaluate the influence of steroids and gonadotropins on reproduction in beef cattle. In experiment 1, beef heifers… (more)

▼ The objective of this thesis was to evaluate the influence of steroids and gonadotropins on reproduction in beef cattle. In experiment 1, beef heifers were used to determine the influence of growth-promoting implants on growth, reproductive development, estrous behavior, and pregnancy rate. Heifers were assigned to 1 of 4 implant treatment groups: control (CON); trenbolone acetate (TBA); trenbolone acetate plus estradiol (TBA+E2) or zeranol (ZER). Heifers were implanted once, A.I. and exposed to bull during this experiment. Body weight, BCS, HH, RTS, estrous behavior and pregnancy data were collected throughout this experiment. Average daily gain of heifers was greater for TBA+E2 heifers. Fewer heifers treated with ZER were classified with a cyclic RTS on d 106 than CON and TBA treated heifers while heifers treated with TBA+E2 were similar to all treatments. Heifers treated with TBA had increased mounts during estrus compared with all other treatments. Overall and A.I pregnancy rates did not differ among treatments.In experiment 2, superovulated beef donors were utilized to determine the feasibility of performing a cow-side LH assay (PrediBov®) on superovulated donors, with emphasis on determining how to use the results in a commercial program. Donors were subjected to superstimulation; blood samples were collected starting at CIDR removal, continuing every 6 h until a positive test was acquired or 36 h after CIDR removal. Whole blood (0.5 mL) was submitted to the assay and donors were inseminated approximately 12 and 24 h after a positive test or onset of estrus. The majority of positive LH tests occurred within 12 to 24 h after CIDR removal. Forty-four percent of the positive tests occurred 0 to 6 h after the onset of estrus. Donors that were inseminated 6 to 10 h after a positive LH test produced more viable and grade 1 embryos than donors inseminated either < 6 or 10 to 14 h after a positive test. There were no differences in embryo production between insemination times from the onset of estrus or between donors inseminated approximately 12 and 24 h after a positive test or the onset of estrus. Advisors/Committee Members: Dirk Phillip, Michael L. Looper, Rick W. Rorie.

Subjects/Keywords: Beef Cattle; Embryo Production; Growth-promotants; Reproduction; Endocrinology; Meat Science; Other Animal Sciences; Systems and Integrative Physiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Devine, T. L. (2014). Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle. (Masters Thesis). University of Arkansas. Retrieved from https://scholarworks.uark.edu/etd/2161

Chicago Manual of Style (16^th Edition):

Devine, Thomas L. “Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle.” 2014. Masters Thesis, University of Arkansas. Accessed January 18, 2021. https://scholarworks.uark.edu/etd/2161.

MLA Handbook (7^th Edition):

Devine, Thomas L. “Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle.” 2014. Web. 18 Jan 2021.

Vancouver:

Devine TL. Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle. [Internet] [Masters thesis]. University of Arkansas; 2014. [cited 2021 Jan 18]. Available from: https://scholarworks.uark.edu/etd/2161.

Council of Science Editors:

Devine TL. Influence of Steroids and Gonadotropins on Reproduction in Beef Cattle. [Masters Thesis]. University of Arkansas; 2014. Available from: https://scholarworks.uark.edu/etd/2161

Open Access Theses and Dissertations