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1. -8029-8983. Paper-based electrochemical platforms for separation, enrichment, and detection.

Degree: PhD, Chemistry, 2017, University of Texas – Austin

Paper based analytical devices (PADs) have great potential in the application of point-of-care diagnosis. This dissertation focuses on the design and application of PADs, especially ones that integrate with electrochemical systems, to tackle various problems in analytical chemistry, such as multi-analyte separation, sample enrichment, and sensitive detection. Four types of PADs are described in this dissertation. The first PAD (oPAD-Ep) is designed for multi-analyte separation. The oPAD-Ep is fabricated using the principle of origami to create a stack of connected paper layers as an electrophoresis channel. Due to the thinness of paper, a high electric field can be achieved with low voltage supply. Serum proteins can be separated and the device can be unfolded for post-analysis. The second PAD (oPAD-ITP) is designed on a similar principle as the oPAD-Ep, but it is applied for sample enrichment. The major modification is to adjust electrolyte conditions to enable isotachophoretic enrichment of analytes. DNA with various lengths can be enriched within a few minutes, and can be collected on one of the paper folds. The third PAD (hyPAD) also focuses on sample enrichment. The device is assembled with two different paper materials, nitrocellulose and cellulose. The hyPAD can perform faradaic ion concentration polarization experiments. This technique uses faradaic electrochemistry to create a local electric field gradient in the paper channel and can enrich charged analytes including: DNA, proteins, and nanoparticles. The fourth PAD (oSlip-DNA) focuses on sensitive electrochemical detection of DNA hybridization assays. This method integrates magnetic enrichment and electrochemical signal amplification via silver nanoparticles. Using voltammetry, sensitive detection of Hepatitis B Virus DNA is achieved on the low-cost device. Advisors/Committee Members: Crooks, Richard M. (Richard McConnell) (advisor), Stevenson, Keith J. (committee member), Shear, Jason B. (committee member), Mullins, Charles B. (committee member), Werth, Charles J. (committee member).

Subjects/Keywords: Point-of-care; Electrochemistry; Paper-based analytical devices; Diagnosis; Electrochemical platforms; Paper-based; Multi-analyte separation; Sample enrichment; Sensitive electrochemical detection

…111 ix Chapter 5: Detection of Hepatitis B Virus DNA with a Paper Electrochemical Sensor… …Conventional Electrochemical Cell .................... 130 5.4.4 DNA Sandwich Assay in the oSlip-DNA… …a conventional electrochemical cell. ..................................... 132 Figure 5.4… …Photograph of the conventional electrochemical cell. ................... 124 xv Illustration 5.4… …Electrochemistry. Electrochemical analysis has great potential application in POC diagnosis for… 

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APA (6th Edition):

-8029-8983. (2017). Paper-based electrochemical platforms for separation, enrichment, and detection. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/47353

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Chicago Manual of Style (16th Edition):

-8029-8983. “Paper-based electrochemical platforms for separation, enrichment, and detection.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed June 06, 2020. http://hdl.handle.net/2152/47353.

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MLA Handbook (7th Edition):

-8029-8983. “Paper-based electrochemical platforms for separation, enrichment, and detection.” 2017. Web. 06 Jun 2020.

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Vancouver:

-8029-8983. Paper-based electrochemical platforms for separation, enrichment, and detection. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2020 Jun 06]. Available from: http://hdl.handle.net/2152/47353.

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Council of Science Editors:

-8029-8983. Paper-based electrochemical platforms for separation, enrichment, and detection. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/47353

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

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