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You searched for subject:(Eimeria maxima). Showing records 1 – 3 of 3 total matches.

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1. Brito, Luciana da Silva. Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte.

Degree: 2013, Universidade Federal do Amazonas

A avicultura é considerada uma importante atividade econômica em diversos países. Em instalações de grande escala de criação, onde aves são expostas a fatores estressantes, problemas relacionados a doenças e deterioração das condições ambientais ocorrem freqüentemente e resultam em graves perdas econômicas. Apesar de ser uma doença relativamente antiga, a coccidiose ainda é uma das principais enfermidades causadoras de perdas econômicas em frangos de corte e reprodutoras. O presente trabalho visa avaliar as alterações patológicas e metabólicas em frangos de corte infectados experimentalmente com oocistos esporulados de Eimeria maxima. A pesquisa foi desenvolvida na Escola de Medicina Veterinária e Zootecnia da Universidade Federal do Tocantins (UFT), localizada no município de Araguaína – TO, onde foram realizados o protocolo experimental e as análises zootécnicas; no Laboratório de Histologia da Universidade Federal do Amazonas (UFAM), em Manaus-AM, onde foram realizadas a confecção e análise das lâminas histológicas; e no Laboratório de Análises Clinicas do Hospital Regional de Coari, município de Coari – AM, onde foram feitas as análises bioquímicas. Para realização do experimento, foram utilizados 150 frangos de corte da linhagem Coob, machos, com dez dias de idade, randomizados de acordo com o peso e distribuídos em dois grupos experimentais: grupo controle, sendo inoculado com 0,5 ml de água destilada; grupo infectado, inoculado com 0,5ml de solução contendo 5x104 oocistos esporulados de Eimeria maxima. O desempenho zootécnico foi avaliado no 0 (dia da inoculação), 5°, 10°, 15°, 25° e 35° dpi, sendo abatidas, por deslocamento cervical, quinze aves/grupo. Os primeiros sinais clínicos foram perceptíveis no 5º dpi, onde as aves apresentaram apatia seguida de diarreia fétida, mucóide, penas eriçadas e ganho de peso inferior quando comparado com as aves do grupo controle. Ao final do experimento o grupo controle produziu 28,839 kg de carne e o grupo infectado 28,053kg de carne dos frangos utilizados no trabalho. Apesar da somatória na produção da carne ter sido maior no grupo controle O peso do coração e da moela dos animais experimentais não apresentou diferença significativa, já o fígado teve diferença no dia 5°, 15° e 35° dpi. Quanto ao hematócrito os frangos experimentais não apresentaram diferença significativa (p>0,05) desde o início do experimento até o final, 5° - 35°dpi. Os níveis de proteínas mantiveram- se significantes (p<0,05) em todos os dias de coleta. A avaliação patológica evidenciou mucosa congesta e presença de grande quantidade de muco no 6º dpi. Diante disso, conclui- se que a dose de 5x103 de E. maxima inoculada no grupo experimental foi suficiente para ocasionar danos ao organismo animal.

The poultry industry is an important economic activity in many countries. In large-scale installations of creation, which birds are exposed to stressors, problems related to diseases and deteriorating environmental conditions often occur and result in serious economic losses. Despite being a relatively old…

Advisors/Committee Members: Freitas, Fagner Luiz da Costa, 03220805418, http://lattes.cnpq.br/1494914070526273, [email protected].

Subjects/Keywords: Avicultura; Eimeria maxima; Frangos de corte; CIENCIAS BIOLOGICAS: IMUNOLOGIA

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APA (6th Edition):

Brito, L. d. S. (2013). Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/5896

Chicago Manual of Style (16th Edition):

Brito, Luciana da Silva. “Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte.” 2013. Masters Thesis, Universidade Federal do Amazonas. Accessed January 21, 2020. http://tede.ufam.edu.br/handle/tede/5896.

MLA Handbook (7th Edition):

Brito, Luciana da Silva. “Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte.” 2013. Web. 21 Jan 2020.

Vancouver:

Brito LdS. Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2013. [cited 2020 Jan 21]. Available from: http://tede.ufam.edu.br/handle/tede/5896.

Council of Science Editors:

Brito LdS. Infecção experimental com oocistos esporulados de eimeria maxima (apicomplexa: eimeriidae) em frangos de corte. [Masters Thesis]. Universidade Federal do Amazonas; 2013. Available from: http://tede.ufam.edu.br/handle/tede/5896

2. Wils, Emma. The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis.

Degree: MS, 0002, 2012, University of Illinois – Urbana-Champaign

Three experiments were conducted to determine the combined effects of purified dietary fiber and dietary threonine (Thr) on chick growth and intestinal health. The objectives of the first two experiments were to define the individual effect of purified fiber on nutrient digestibility, dietary Thr requirements, and intestinal structure of young chicks. Additionally, a third experiment was conducted to investigate the immune-modulating properties of purified fiber and dietary Thr during an Eimeria maxima coccidiosis infection. In Experiment 1, chicks received corn/soybean meal (SBM) based diets containing 7% added silica sand (control), cellulose, or high-methoxy pectin through d 14 post-hatch. Inclusion of pectin reduced (P < 0.05) weight gain by 32% when compared to other treatments, and resulted in a reduction (P < 0.05) in DM digestibility, as well as AMEn, compared with the control diet.. Based on the energy values attributed to pectin and cellulose, dietary treatments in Experiment 2 and 3 were designed to be isocaloric. In Experiment 2, effects of purified fiber on dietary Thr requirements were determined using a Thr-deficient basal (3.2 g/kg diet) diet containing 7% added silica sand (control), cellulose, or pectin, and one of 7 graded levels of supplemental Thr (0 to 7.2 g/kg of diet). Dietary supplemental Thr requirements in the presence of silica sand (control), cellulose, and pectin were estimated at 778, 737, and 576 mg of supplemental Thr intake over the 14-d feeding period, respectively, based on body weight gain. In Experiment 3, diets were based on the same semi-purified basal diet used in Experiment 2, but the fiber-containing diets were supplemented with 1.8 or 5.3 g of Thr/kg diet [75 and 125% of the previously determined Thr requirement (6.8 g Thr/ kg diet) in Experiment 2]. In Experiment 3, body weight gain, feed intake, and gain:feed increased (P < 0.01) with the addition of 5.3 g of Thr/ kg diet. Eimeria. iii maxima schizonts were only present in intestinal tissue sampled from infected birds (P < 0.01). Cecal content weights were highest (P < 0.01) in pectin-fed birds. Cecal tonsil IFNG and mucosal scrapings IL-12 were increased (P < 0.01) in the control diet with infection. These findings suggest that both fiber source and dietary Thr concentration affected growth performance and intestinal health indices in young chicks, which may directly impact poultry feeding strategies. Advisors/Committee Members: Dilger, Ryan N. (advisor).

Subjects/Keywords: chick; cellulose; pectin; threonine; Eimeria maxima

…concentration on growth performance of young chicks prior to E. maxima inoculation (d 0-10 post… …concentration on growth performance of young chicks infected with E. maxima coccidiosis (d 10-16… …infected with E. maxima coccidiosis (d 16 post-hatch)… …x28;reported as fold-change) in young chicks infected with E. maxima coccidiosis (… …E. maxima coccidiosis (d 16 post-hatch) ...................................98… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wils, E. (2012). The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/34389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wils, Emma. “The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis.” 2012. Thesis, University of Illinois – Urbana-Champaign. Accessed January 21, 2020. http://hdl.handle.net/2142/34389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wils, Emma. “The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis.” 2012. Web. 21 Jan 2020.

Vancouver:

Wils E. The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2012. [cited 2020 Jan 21]. Available from: http://hdl.handle.net/2142/34389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wils E. The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis. [Thesis]. University of Illinois – Urbana-Champaign; 2012. Available from: http://hdl.handle.net/2142/34389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Brandeis University

3. Xu, Changhan. The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa.

Degree: 2017, Brandeis University

Apicomplexa are unicellular eukaryotic parasites of many animals, including humans. The most notorious example is malaria, caused by the apicomplexan parasite Plasmodium falciparum. The apicomplexan lactate dehydrogenase enzyme (LDH) evolved independently from human and other "canonical" LDHs found in the host. Apicomplexan LDHs have distinct structures from the host LDHs, and thus they have been identified as a drug target for the parasitic diseases. Plasmodium falciparum LDH (PfLDH) has been extensively studied due to its value for drug targeting, and yet the mechanistic and evolutionary basis of the functional and structural divergence of the entire apicomplexan LDH family is still not well-understood. A related apicomplexan parasite, Eimeria maxima, is the cause of an economically significant disease of poultry. To further explore the source of the functional divergence in apicomplexan LDHs, I characterized the kinetic and specificity profile for PfLDH, Eimeria maxima LDH (EmLDH), and their most recent common ancestor (AncLDH) calculated from extant sequences, using different substrates. PfLDH diverged from AncLDH by evolving high specificity toward pyruvate, having very low activities toward other bigger and hydrophobic substrates. EmLDH, on the other hand, largely retains the specificity profile from the AncLDH ancestor: both EmLDH and AncLDH have reduced activities toward other alternative substrates, but the magnitudes were no match to PfLDH. The most prominent difference can be seen when phenylpyruvate was used as an alternative substrate. PfLDH has very limited activity toward this hydrophobic substrate, while AncLDH and EmLDH are both able to ignore the phenyl ring and turn over phenylpyruvate at an efficiency only marginally lower than turning over the native substrate pyruvate. I have also solved the first crystal structure for EmLDH (1.8 Å). Structural comparison of EmLDH, PfLDH, and AncLDH shows several residue differences near the active site, and it is likely that the differences in their specificity profiles can be attributed to these residues. Preliminary data also suggests that the rate-limiting step for EmLDH is after the hydride transfer step, similar to PfLDH. This work will serve as a foundation for further understanding the origin of the convergent evolution of LDH function in the Apicomplexa.

Subjects/Keywords: Lactate dehydrogenase; Apicomplexa; Enzyme substrate specificity; Protein evolution; Plasmodium falciparum; Eimeria maxima; Enzyme kinetics; X-Ray Crystallography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xu, C. (2017). The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/33900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Xu, Changhan. “The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa.” 2017. Thesis, Brandeis University. Accessed January 21, 2020. http://hdl.handle.net/10192/33900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Xu, Changhan. “The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa.” 2017. Web. 21 Jan 2020.

Vancouver:

Xu C. The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa. [Internet] [Thesis]. Brandeis University; 2017. [cited 2020 Jan 21]. Available from: http://hdl.handle.net/10192/33900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu C. The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in the Apicomplexa. [Thesis]. Brandeis University; 2017. Available from: http://hdl.handle.net/10192/33900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.