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McMaster University
1.
Tao, Ashley T.
Advanced Methods in Molecular Breast Imaging.
Degree: PhD, 2016, McMaster University
URL: http://hdl.handle.net/11375/19900 
► Molecular breast imaging (MBI) is a relatively new clinical breast imaging modality, which has the potential to have a significant impact in breast cancer screening…
(more)
▼ Molecular breast imaging (MBI) is a relatively new clinical breast imaging modality, which has the potential to have a significant impact in breast cancer screening and perioperative breast imaging for women with high risk factors for developing breast cancer. Two objectives were proposed in this thesis to increase the use of MBI. First, a magnetic resonance (MR)-compatible gamma camera was developed for combined molecular/MR breast imaging. MBI is a functional imaging technique with high specificity and sensitivity but could benefit from the addition of anatomical information from breast MRI for lesion localization, cancer staging, treatment planning and monitoring. A small area (8cm x 8cm) cadmium zinc telluride (CZT) based gamma camera was developed and tested for MR compatibility in both sequential and simultaneous imaging conditions. Results indicated that the gamma camera was minimally affected during both sequential and simultaneous imaging with a gradient echo (GRE) and spoiled gradient echo (GRE) sequence. Signal to noise ratio (SNR) degradation was observed in the MR images but no geometric distortions were observed. Simultaneous imaging is feasible, but a reassessment of the RF shielding would be required to minimize the noise contribution degrading image quality. Second, backscatter photons were investigated as a potential dose reduction technique for MBI. While the effective dose from MBI is relatively low in comparison to other nuclear medicine procedures, the dose is considered high in relation to mammography and in order to increase acceptance as an alternative breast imaging method, dose reduction is an important objective. Backscatter photons have the same spatial information as primary photons but are typically discarded along with other scattered photons. A scatter compensation method called the triple energy window (TEW) was used to extract backscatter photons from the Compton scattering spectrum and added to the primary photons, increasing count sensitivity by 6%. The noise level matched the increase in contrast leading to negligible change in lesion contrast to noise ratio (CNR). Dose reduction is not justified with this particular technique because of the elevated noise level, but the use of backcsatter photons show potential with improved contrast.
Dissertation
Doctor of Philosophy (PhD)
Advisors/Committee Members: Farncombe, Troy H., Medical Physics.
Subjects/Keywords: Molecular breast imaging; MRI; Nuclear medicine; Dual-modality imaging; Backscatter
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APA (6th Edition):
Tao, A. T. (2016). Advanced Methods in Molecular Breast Imaging. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/19900
Chicago Manual of Style (16th Edition):
Tao, Ashley T. “Advanced Methods in Molecular Breast Imaging.” 2016. Doctoral Dissertation, McMaster University. Accessed January 15, 2021.
http://hdl.handle.net/11375/19900.
MLA Handbook (7th Edition):
Tao, Ashley T. “Advanced Methods in Molecular Breast Imaging.” 2016. Web. 15 Jan 2021.
Vancouver:
Tao AT. Advanced Methods in Molecular Breast Imaging. [Internet] [Doctoral dissertation]. McMaster University; 2016. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/11375/19900.
Council of Science Editors:
Tao AT. Advanced Methods in Molecular Breast Imaging. [Doctoral Dissertation]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/19900
University of Ottawa
2.
Polskaia, Nadia.
The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
.
Degree: 2015, University of Ottawa
URL: http://hdl.handle.net/10393/32870
► The purpose of the present thesis was two-fold. First, to evaluate the impact of cognitive demand on postural control in young adults and second, to…
(more)
▼ The purpose of the present thesis was two-fold. First, to evaluate the impact of cognitive demand on postural control in young adults and second, to examine the responsiveness of postural control to cognitive tasks presented in varying modalities. Seventeen young adults stood on a force platform while simultaneously performing cognitive tasks of varying difficulty (easy, moderate and difficult), each presented auditorily and visually. Performing the moderate and difficult tasks precipitated a greater reduction in area of 95% confidence ellipse and medio-lateral (ML) sway variability compared to the easy tasks. Presenting the tasks visually produced lower ML sway variability than presenting the tasks auditorily. Of secondary interest of this thesis was to determine if the duration of inter-stimulus intervals could modify the effectiveness of a cognitive task on postural control. Participants stood on a force platform while simultaneously performing cognitive tasks with five-second inter-stimulus intervals (i.e. discrete) and two-second inter-stimulus intervals (i.e. continuous), each presented auditorily and visually. Results revealed higher anterior-posterior (AP) mean power frequency (MPF) when performing the continuous tasks. In addition, presented the tasks visually resulted in a greater reduction in area of 95% confidence ellipse, AP and ML sway variability.
Subjects/Keywords: Postural control;
Dual-task;
Cognitive Task;
Sensory Modality
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APA (6th Edition):
Polskaia, N. (2015). The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/32870
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Polskaia, Nadia. “The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
.” 2015. Thesis, University of Ottawa. Accessed January 15, 2021.
http://hdl.handle.net/10393/32870.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Polskaia, Nadia. “The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
.” 2015. Web. 15 Jan 2021.
Vancouver:
Polskaia N. The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
. [Internet] [Thesis]. University of Ottawa; 2015. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/10393/32870.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Polskaia N. The Impact of Auditory and Visual Cognitive Tasks on Postural Control in Young Adults
. [Thesis]. University of Ottawa; 2015. Available from: http://hdl.handle.net/10393/32870
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
3.
Masoodzadehgan, Nazanin.
PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS.
Degree: PhD, Mechanical Engineering, 2014, Georgia Tech
URL: http://hdl.handle.net/1853/54253
► Early stage disease diagnosis still remains a challenge despite much efforts to develop novel imaging and diagnostic techniques. Nanoparticles used as molecular imaging contrast agents…
(more)
▼ Early stage disease diagnosis still remains a challenge despite much efforts to develop novel imaging and diagnostic techniques. Nanoparticles used as molecular imaging contrast agents with multifunctionality and flexibility provide a platform for targeting the specific disease biomarkers and integration of imaging modalities. In this work, we developed a simplified method for synthesis of radiolabeled targeted super paramagnetic iron oxide nanoparticles (SPIOs). This method takes advantage of the chelator BAT that is conjugated to the PEG before the coating process begins. The effect of nanoparticle size and PEG density was investigated in a series of in vivo experiments. The 64Cu-VINP-SPIOs were used in the PET imaging of inflammation and 64Cu-CD105-SPIOs were used in imaging of 4T1 murine tumor model. In summary, we investigated the potential of the radiolabeled, targeted SPIOs in imaging atherosclerotic plaque and tumor in vivo using magnetic resonance imaging (MRI) and Positron emission tomography (PET). Our results show that
dual modality SPIOs with active targeting mediated by affinity ligands can be a great tool in molecular imaging and diagnosis of early stage plaque and tumor.
Advisors/Committee Members: Bao, Gang (advisor), Rahnema, Farzad (committee member), Goodman, Mark (committee member), Taylor, Robert (committee member), Mao, Hui (committee member), Liu, Yongjian (committee member).
Subjects/Keywords: SPIO; Imaging; Disease; PET/MR; Targeting; Dual modality; Radiolabeling
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APA (6th Edition):
Masoodzadehgan, N. (2014). PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/54253
Chicago Manual of Style (16th Edition):
Masoodzadehgan, Nazanin. “PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS.” 2014. Doctoral Dissertation, Georgia Tech. Accessed January 15, 2021.
http://hdl.handle.net/1853/54253.
MLA Handbook (7th Edition):
Masoodzadehgan, Nazanin. “PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS.” 2014. Web. 15 Jan 2021.
Vancouver:
Masoodzadehgan N. PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS. [Internet] [Doctoral dissertation]. Georgia Tech; 2014. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/1853/54253.
Council of Science Editors:
Masoodzadehgan N. PET/MR imaging of atherosclerotic plaque and tumor using dual modality SPIOS. [Doctoral Dissertation]. Georgia Tech; 2014. Available from: http://hdl.handle.net/1853/54253
University of Texas – Austin
4.
Wilson, Katheryne Elizabeth.
Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.
Degree: PhD, Biomedical Engineering, 2012, University of Texas – Austin
URL: http://hdl.handle.net/2152/ETD-UT-2012-05-5386
► The recent increase in survival rates of most cancers is due to early detection greatly aided by medical imaging modalities. Combined ultrasound and photoacoustic imaging…
(more)
▼ The recent increase in survival rates of most cancers is due to early detection greatly aided by medical imaging modalities. Combined ultrasound and photoacoustic imaging provide both morphological and functional/molecular information which can help to detect and diagnose cancer in its earliest stages. However, both modalities can benefit from the use of contrast agents. The objective of this thesis was to design, synthesize, and test a nano-sized,
dual contrast agent for combined ultrasound and photoacoustic imaging named Photoacoustic nanoDroplets. This agent consists of liquid perfluorocarbon nanodroplets with encapsulated plasmonic nanoparticles. These
dual contrast agents utilize optically triggered vaporization for photoacoustic signal generation, providing significantly higher signal amplitude than that from the traditionally used mechanism, thermal expansion. Upon pulsed laser irradiation, liquid perfluorocarbon undergoes a liquid-to-gas phase transition generating giant photoacoustic transients from these dwarf nanoparticles. Once triggered, the gaseous phase provides ultrasound contrast enhancement. Demonstrated in this work are the design, synthesis, characterization, and testing of Photoacoustic nanoDroplets in phantom and animal studies, and preliminary work into adapting these agents into targeted, drug delivery vehicles for simultaneous detection, diagnosis, and treatment of diseases.
Advisors/Committee Members: Emelianov, Stanislav Y. (advisor), Fowlkes, Brian (committee member), Hamilton, Mark (committee member), Sokolov, Konstantin (committee member), Williams, Robert (committee member).
Subjects/Keywords: Ultrasound imaging; Photoacoustic imaging; Contrast agent; Perfluorocarbon; Droplets; Nanoparticles; Dual modality
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APA ·
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Manager
APA (6th Edition):
Wilson, K. E. (2012). Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2012-05-5386
Chicago Manual of Style (16th Edition):
Wilson, Katheryne Elizabeth. “Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.” 2012. Doctoral Dissertation, University of Texas – Austin. Accessed January 15, 2021.
http://hdl.handle.net/2152/ETD-UT-2012-05-5386.
MLA Handbook (7th Edition):
Wilson, Katheryne Elizabeth. “Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets.” 2012. Web. 15 Jan 2021.
Vancouver:
Wilson KE. Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2012. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5386.
Council of Science Editors:
Wilson KE. Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets. [Doctoral Dissertation]. University of Texas – Austin; 2012. Available from: http://hdl.handle.net/2152/ETD-UT-2012-05-5386
Texas A&M University
5.
Shrestha, Sebina.
Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.
Degree: PhD, Biomedical Engineering, 2015, Texas A&M University
URL: http://hdl.handle.net/1969.1/155617
► Both morphological and biochemical changes occur in a diseased tissue. As a result, tissue optical response changes with the progression of disease. A single optical…
(more)
▼ Both morphological and biochemical changes occur in a diseased tissue. As a result, tissue optical response changes with the progression of disease. A single optical imaging
modality can assess either morphological or biochemical changes. In order to investigate the development of a disease in detail, both of these characteristics need to be probed simultaneously. Therefore, researchers have been interested in combining different imaging modalities that can provide complementary, morphological and biochemical images. This dissertation focuses on the development of
dual-
modality systems that incorporate Optical coherence Tomography (OCT) and Fluorescence Lifetime Imaging Microscopy (FLIM) for simultaneous characterization of tissue morphology and its biochemistry.
In the first phase of the research, we combined spectral-domain OCT with FLIM that is designed for endogenous emission acquisition. The operating wavelength for OCT and FLIM were 830nm and 355nm, respectively. The maximum field of view (FOV) was 4mmx4mm. The combined system was used to image hamster cheek pouch model for oral cancer in vivo and postmortem human coronary arteries with atherosclerotic plaques ex vivo. Their morphological and endogenous emission images correlation was studied. The evaluation was equivalent to their histopathological analysis.
In the second phase of this research, we built a bench-top prototype that comprised of swept source OCT (SSOCT) and a FLIM system with the capability to characterize endogenous and exogenous emissions simultaneously. The swept laser had a sweep rate of 50 kHz and the center wavelength was at 1310nm. FLIM utilized lasers with wavelengths 355nm and 532nm to excite endogenous and exogenous fluorophores, respectively. The maximum FOV was 16mmx16mm. With this system, OCT-FLIM images of a Watanabe rabbit aorta, which was non-specifically tagged with Alexa Fluor 532, were acquired ex-vivo. The results appraised the ability of the system to simultaneously probe the sample’s structure, its endogenous emission and the exogenous fluorescence of the dye tagged to it. We hypothesize that the OCT-FLIM imaging tool adds a potential to study the activities of important non-fluorescing molecules in an artery while relating the analysis to its morphology and biochemistry.
Advisors/Committee Members: Applegate, Brian E (advisor), Jo, Javier A (committee member), Maitland, Kristen C (committee member), Eknoyan, Ohannes (committee member).
Subjects/Keywords: Optical Coherence Tomography; Fluorescence Lifetime Imaging Microscopy; Atherosclerosis; Oral Cancer; dual-modality optical imaging system
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APA ·
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MLA ·
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APA (6th Edition):
Shrestha, S. (2015). Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/155617
Chicago Manual of Style (16th Edition):
Shrestha, Sebina. “Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.” 2015. Doctoral Dissertation, Texas A&M University. Accessed January 15, 2021.
http://hdl.handle.net/1969.1/155617.
MLA Handbook (7th Edition):
Shrestha, Sebina. “Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.” 2015. Web. 15 Jan 2021.
Vancouver:
Shrestha S. Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/1969.1/155617.
Council of Science Editors:
Shrestha S. Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/155617
Duke University
6.
Shah, Jainil.
Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
.
Degree: 2015, Duke University
URL: http://hdl.handle.net/10161/11310
► X-ray mammography has been the gold standard for breast imaging for decades, despite the significant limitations posed by the two dimensional (2D) image acquisitions.…
(more)
▼ X-ray mammography has been the gold standard for breast imaging for decades, despite the significant limitations posed by the two dimensional (2D) image acquisitions. Difficulty in diagnosing lesions close to the chest wall and axilla, high amount of structural overlap and patient discomfort due to compression are only some of these limitations. To overcome these drawbacks, three dimensional (3D) breast imaging modalities have been developed including
dual modality single photon emission computed tomography (SPECT) and computed tomography (CT) systems. This thesis focuses on the development and integration of the next generation of such a device for dedicated breast imaging. The goals of this dissertation work are to: [1] understand and characterize any effects of fully 3-D trajectories on reconstructed image scatter correction, absorbed dose and Hounsifeld Unit accuracy, and [2] design, develop and implement the fully flexible, third generation hybrid SPECT-CT system capable of traversing complex 3D orbits about a pendant breast volume, without interference from the other. Such a system would overcome artifacts resulting from incompletely sampled divergent cone beam imaging schemes and allow imaging closer to the chest wall, which other systems currently under research and development elsewhere cannot achieve. The dependence of x-ray scatter radiation on object shape, size, material composition and the CT acquisition trajectory, was investigated with a well-established beam stop array (BSA) scatter correction method. While the 2D scatter to primary ratio (SPR) was the main metric used to characterize total system scatter, a new metric called ‘normalized scatter contribution’ was developed to compare the results of scatter correction on 3D reconstructed volumes. Scatter estimation studies were undertaken with a sinusoidal saddle (±15° polar tilt) orbit and a traditional circular (AZOR) orbit. Clinical studies to acquire data for scatter correction were used to evaluate the 2D SPR on a small set of patients scanned with the AZOR orbit. Clinical SPR results showed clear dependence of scatter on breast composition and glandular tissue distribution, otherwise consistent with the overall phantom-based size and density measurements. Additionally, SPR dependence was also observed on the acquisition trajectory where 2D scatter increased with an increase in the polar tilt angle of the system. The dose delivered by any imaging system is of primary importance from the patient’s point of view, and therefore trajectory related differences in the dose distribution in a target volume were evaluated. Monte Carlo simulations as well as physical measurements using radiochromic film were undertaken using saddle and AZOR orbits. Results illustrated that both orbits deliver comparable dose to the target volume, and only slightly differ in distribution within the volume. Simulations and measurements showed similar results, and all measured dose values were within the standard screening mammography-specific, 6 mGy dose…
Advisors/Committee Members: Tornai, Martin P (advisor).
Subjects/Keywords: Biomedical engineering;
Medical imaging;
Engineering;
Breast CT;
Dose;
Dual Modality;
Mammotomography;
Scatter;
SPECT-CT
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APA (6th Edition):
Shah, J. (2015). Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/11310
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shah, Jainil. “Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
.” 2015. Thesis, Duke University. Accessed January 15, 2021.
http://hdl.handle.net/10161/11310.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shah, Jainil. “Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
.” 2015. Web. 15 Jan 2021.
Vancouver:
Shah J. Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
. [Internet] [Thesis]. Duke University; 2015. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/10161/11310.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shah J. Investigation and Development of a Fully 3D Tilt Capable Hybrid SPECT - CT System for Dedicated Breast Imaging
. [Thesis]. Duke University; 2015. Available from: http://hdl.handle.net/10161/11310
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
Rodriguez Frias, Marco Antonio.
ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION.
Degree: 2015, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:272584
► Multi-phase flow measurement is a challenging task due to the involvement of differ-ent flow regimes, materials and a varying water-in-liquid ratio (WLR). One approachresearchers have…
(more)
▼ Multi-phase flow measurement is a challenging task
due to the involvement of differ-ent flow regimes, materials and a
varying water-in-liquid ratio (WLR). One approachresearchers have
taken to tackle this difficult task, is the development of
dual-modalityimaging systems, fusing Electrical Capacitance
Tomography (ECT) and Electrical Re-sistance Tomography (ERT) in a
single measuring device. This is due to the abilityof each
technique to take advantage of different phenomena, i.e. imaging
conductivemedia is a demanding task for ECT, but ERT yields good
quality results. On the otherhand, with an ERT system is not
possible to get any information regarding the regionof interest if
there is no conductive media to allow the current to flow, but in
this caseECT can perform the imaging exploiting the materials’
dielectric properties. Becauseof those characteristics
dual-
modality tomography has been foreseen as a practical anda low
cost solution to image a wide range of complex media.Through years,
ERT has proven to be an effective and a low cost imaging
technique,but in order to integrate it to a
dual-
modality imaging
system in parallel with ECT,it is necessary to improve it and at
the same time to make it more compatible to thecapacitive imaging
technique, allowing in this way to exploit the best capabilities
ofboth modalities. This requires a complete sensor and circuitry
redesign.An ERT system has been developed featuring a voltage
excitation and current mea-surement sensing scheme making use of an
ECT sensor built with electrodes insidethe vessel and an available
data acquisition system. This set up images
successfullynon-conductive material over liquid solutions with low
and high conductivities as abackground.A comparison between current
excitation and voltage measurement ERT and voltageexcitation and
current measurement ERT is performed showing that the latter not
onlymakes ERT more suitable to integrate with a ECT system, but
also improves its perfor-mance. The design of a sensor with
internal electrodes and driven external guards canreduce notably
the fringe effect and improve the images obtained by means of an
ERTsystem.
Advisors/Committee Members: YIN, WULIANG W, Yang, Wuqiang, Yin, Wuliang.
Subjects/Keywords: ECT; ERT; DUAL MODALITY TOMOGRAPHY
…exploiting the materials’ dielectric properties. Because
of those characteristics dual-modality… …but in order to integrate it to a dual-modality imaging system in parallel with ECT,
it is… …hardware development.
Dual-modality tomography has appeared as a possible solution for the… …single frequency with
the use of a dual modality imaging system.
12
1.2. OBJECTIVES OF THE… …ERT in a dual-modality
system. Cui et al. (2009) developed a system integrating…
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APA (6th Edition):
Rodriguez Frias, M. A. (2015). ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:272584
Chicago Manual of Style (16th Edition):
Rodriguez Frias, Marco Antonio. “ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION.” 2015. Doctoral Dissertation, University of Manchester. Accessed January 15, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:272584.
MLA Handbook (7th Edition):
Rodriguez Frias, Marco Antonio. “ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION.” 2015. Web. 15 Jan 2021.
Vancouver:
Rodriguez Frias MA. ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION. [Internet] [Doctoral dissertation]. University of Manchester; 2015. [cited 2021 Jan 15].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:272584.
Council of Science Editors:
Rodriguez Frias MA. ELECTRICAL CAPACITANCE AND RESISTANCE TOMOGRAPHY WITH
VOLTAGE EXCITATION. [Doctoral Dissertation]. University of Manchester; 2015. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:272584
University of New South Wales
8.
Zhang, Fan.
Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering.
Degree: Mechanical & Manufacturing Engineering, 2020, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/65038
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63682/SOURCE02?view=true
► To mimic human’s skin, wearable strain sensors that enable to detect multiple stimuli in the outside environment have been attracted a lot of attentions. One…
(more)
▼ To mimic human’s skin, wearable strain sensors that enable to detect multiple stimuli in the outside environment have been attracted a lot of attentions. One promising way to facilitate the wearable strain sensors processing is to utilise composites combing conductive fillers with deformable polymer matrix. This thesis firstly presents a brief introduction of the research advances of wearable strain sensors. Based on this review, a set of research questions and aims were formulated. The aims of this thesis are rational designs for wearable strain sensors with high sensitivity, high stretchability, low drift and multi-
modality.PDMS composites reinforced by a
dual-scale carbon nanofibres network consisting of carbon nanofibres (CNFs) and short carbon fibres (SCFs) were fabricated to obtain a trade-off between sensitivity and stretchability compared to the composites with either CNFs or SCFs only. To further reduce the drift, a sandwich-like strain sensor by embedding 1D carbon nanofibres (CNFs) and 2D graphene nanoplates (GNPs) in a polydimethylsiloxane has been prepared to exhibit a high linearity up to 50% strain, a higher sensitivity and a much better stability in long-term cyclic tests. This can be attributed to the synergistic effect of 1D and 2D nano-carbons in creating a robust conductive work quantitatively analysed by synergy ratios. Moreover, this new highly flexible sensor enables to detect both large and subtle strain deformation of human motions as electronic skins. To achieve multi-
modality sensing, wearable strain sensors made of hybrid aerogel of PEDOT:PSS and reduced graphene oxides (rGO) in a PDMS matrix has been presented, exhibiting positive and negative sensitivity to strain and temperature change. To differentiate the strain and temperature by using one single sensor, a new impedance method has also been employed by measuring impedance of this type of hybrid sensor at two different frequencies. Practical application demonstrations to detect various joint motions and the cyclic motion of a linear stage under different temperatures showed promising potentials in soft robotics. In summary, the strategies by combining
dual-scale fillers and structural engineering pave the way to realise rational design of wearable strain sensors for practical applications.
Advisors/Committee Members: Wang, Chun, Mechanical & Manufacturing Engineering, Faculty of Engineering, UNSW.
Subjects/Keywords: Structural engineering; Wearable strain sensors; Dual-scale fillers; Rational design; Multi-modality
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Manager
APA (6th Edition):
Zhang, F. (2020). Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/65038 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63682/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Zhang, Fan. “Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering.” 2020. Doctoral Dissertation, University of New South Wales. Accessed January 15, 2021.
http://handle.unsw.edu.au/1959.4/65038 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63682/SOURCE02?view=true.
MLA Handbook (7th Edition):
Zhang, Fan. “Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering.” 2020. Web. 15 Jan 2021.
Vancouver:
Zhang F. Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Jan 15].
Available from: http://handle.unsw.edu.au/1959.4/65038 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63682/SOURCE02?view=true.
Council of Science Editors:
Zhang F. Rational design of wearable strain sensors by employing dual-scale fillers and structural engineering. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/65038 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63682/SOURCE02?view=true
McMaster University
9.
Tao, Ashley T.
Development of a Silicon Photomultiplier Based Gamma Camera.
Degree: MSc, 2011, McMaster University
URL: http://hdl.handle.net/11375/11449
► Dual modality imaging systems such as SPECT/CT have become commonplace in medical imaging as it aids in diagnosing diseases by combining anatomical images with…
(more)
▼ Dual modality imaging systems such as SPECT/CT have become commonplace in medical imaging as it aids in diagnosing diseases by combining anatomical images with functional images. We are interested in developing a dual modality imaging system combining SPECT and MR imaging because MR does not require any ionizing radiation to image anatomical structures and it is known to have superior soft tissue contrast to CT. However, one of the fundamental challenges in developing a SPECT/MR system is that traditional gamma cameras with photomultiplier tubes are not compatible within magnetic fields. New development in solid state detectors has led to the silicon photomultiplier (SiPM), which is insensitive to magnetic fields. We have developed a small area gamma camera with a tileable 4x4 array of SiPM pixels coupled with a CsI(Tl) scintillation crystal. A number of simulated gamma camera geometries were performed using both pixelated and monolithic scintillation crystals. Several event positioning algorithms were also investigated as an alternative to conventional Anger logic positioning. Simulations have shown that we can adequately resolve intrinsic spatial resolution down to 1mm, even in the presence of noise. Based on the results of these simulations, we have built a prototype SiPM system comprised of 16 detection channels coupled to discrete crystals. A charge sensitive preamplifier, pulse height detection circuit and a digital acquisition system make up our pulse processing components in our gamma camera system. With this system, we can adequately distinguish each crystal element in the array and have obtained an energy resolution of 30±1 (FWHM) with Tc-99m (140keV). In the presence of a magnetic field, we have seen no spatial distortion of the resultant image and have obtained an energy resolution of 31±3.
Master of Science (MSc)
Advisors/Committee Members: Farncombe, Troy H, Soo Hyun Byun, Nicholas Bock, Soo Hyun Byun, Nicholas Bock, Medical Physics.
Subjects/Keywords: silicon photomultipliers; semiconductor detectors; SPECT/MR; dual-modality imaging; Biomedical devices and instrumentation; Biomedical devices and instrumentation
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APA (6th Edition):
Tao, A. T. (2011). Development of a Silicon Photomultiplier Based Gamma Camera. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/11449
Chicago Manual of Style (16th Edition):
Tao, Ashley T. “Development of a Silicon Photomultiplier Based Gamma Camera.” 2011. Masters Thesis, McMaster University. Accessed January 15, 2021.
http://hdl.handle.net/11375/11449.
MLA Handbook (7th Edition):
Tao, Ashley T. “Development of a Silicon Photomultiplier Based Gamma Camera.” 2011. Web. 15 Jan 2021.
Vancouver:
Tao AT. Development of a Silicon Photomultiplier Based Gamma Camera. [Internet] [Masters thesis]. McMaster University; 2011. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/11375/11449.
Council of Science Editors:
Tao AT. Development of a Silicon Photomultiplier Based Gamma Camera. [Masters Thesis]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/11449
Rice University
10.
Glaser, Daniel Shields.
Implications of differences of echoic and iconic memory for the design of multimodal displays.
Degree: PhD, Social Sciences, 2012, Rice University
URL: http://hdl.handle.net/1911/70248
► It has been well documented that dual-task performance is more accurate when each task is based on a different sensory modality. It is also well…
(more)
▼ It has been well documented that
dual-task performance is more accurate when each task is based on a different sensory
modality. It is also well documented that the memory for each sense has unequal durations, particularly visual (iconic) and auditory (echoic) sensory memory. In this dissertation I address whether differences in sensory memory (e.g. iconic vs. echoic) duration have implications for the design of a multimodal display. Since echoic memory persists for seconds in contrast to iconic memory which persists only for milliseconds, one of my hypotheses was that in a visual-auditory
dual task condition, performance will be better if the visual task is completed before the auditory task than vice versa. In Experiment 1 I investigated whether the ability to recall multi-modal stimuli is affected by recall order, with each mode being responded to separately. In Experiment 2, I investigated the effects of stimulus order and recall order on the ability to recall information from a multi-modal presentation. In Experiment 3 I investigated the effect of presentation order using a more realistic task. In Experiment 4 I investigated whether manipulating the presentation order of stimuli of different modalities improves humans' ability to combine the information from the two modalities in order to make decision based on pre-learned rules. As hypothesized, accuracy was greater when visual stimuli were responded to first and auditory stimuli second. Also as hypothesized, performance was improved by not presenting both sequences at the same time, limiting the perceptual load. Contrary to my expectations, overall performance was better when a visual sequence was presented before the audio sequence. Though presenting a visual sequence prior to an auditory sequence lengthens the visual retention interval, it also provides time for visual information to be recoded to a more robust form without disruption. Experiment 4 demonstrated that decision making requiring the integration of visual and auditory information is enhanced by reducing workload and promoting a strategic use of echoic memory. A framework for predicting Experiment 1-4 results is proposed and evaluated.
Advisors/Committee Members: Lane, David M. (advisor).
Subjects/Keywords: Psychology; Pure sciences; Multimodal displays; Echoic memory; Working memory; Dual modality; Dual task; Sensory memory; Condensed matter physics; Experimental psychology; Cognitive psychology
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APA (6th Edition):
Glaser, D. S. (2012). Implications of differences of echoic and iconic memory for the design of multimodal displays. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/70248
Chicago Manual of Style (16th Edition):
Glaser, Daniel Shields. “Implications of differences of echoic and iconic memory for the design of multimodal displays.” 2012. Doctoral Dissertation, Rice University. Accessed January 15, 2021.
http://hdl.handle.net/1911/70248.
MLA Handbook (7th Edition):
Glaser, Daniel Shields. “Implications of differences of echoic and iconic memory for the design of multimodal displays.” 2012. Web. 15 Jan 2021.
Vancouver:
Glaser DS. Implications of differences of echoic and iconic memory for the design of multimodal displays. [Internet] [Doctoral dissertation]. Rice University; 2012. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/1911/70248.
Council of Science Editors:
Glaser DS. Implications of differences of echoic and iconic memory for the design of multimodal displays. [Doctoral Dissertation]. Rice University; 2012. Available from: http://hdl.handle.net/1911/70248
University of Michigan
11.
Sukovic, Predrag.
Design of a dual modality PET/cone beam CT scanner. A feasibility study.
Degree: PhD, Medical imaging, 2003, University of Michigan
URL: http://hdl.handle.net/2027.42/123716
► Positron Emission Tomography (PET) is a noninvasive medical imaging modality that provides quantitative information about human physiology. One of the most rapidly expanding areas of…
(more)
▼ Positron Emission Tomography (PET) is a noninvasive medical imaging
modality that provides quantitative information about human physiology. One of the most rapidly expanding areas of PET imaging is cancer diagnosis. The application of PET in cancer diagnosis is, however, hampered by the attenuation of gamma-rays and poor anatomical localization. The attenuation of gamma-rays is typically accounted for by taking a transmission scan with an external gamma-ray source. Radionuclide transmission scans, however, suffer from a high noise level and take a long time to acquire. The second problem – the imprecise anatomical localization of the metabolic changes – is due to the fact that a PET scan contains very little anatomical information. A solution is to superimpose the PET image with a separately obtained X-ray computed tomography (CT) image. Because the two scans are obtained using different scanners with different geometries and protocols, the fusion is not trivial. Also, these methods require expert supervision and are computationally expensive. As another solution, several
dual modality PET/CT scanners have recently been developed. These devices, however, are typically very expensive and expose the patient to a high radiation dose. We propose a novel PET/CT design that can be developed at a significantly lower cost and exposes the patient to a lower radiation dose. The CT component is based on cone beam mode of scanning. The cone beam CT (CBCT) scan is used to perform the attenuation correction for the PET scan and is fused with the PET scan to produce a combined anato-metabolic image. We have constructed a CBCT test bench to perform feasibility studies. We successfully performed attenuation correction for a PET scan of a torso phantom and demonstrated that the radiation dose can be significantly lower than in diagnostic CT, while maintaining the quality of the attenuation correction. We further proposed several methods for improving upon the performance of the basic design, to of which we dealt with in more detail. First, we proposed a method for improving the dynamic range of the flat panel detectors. Second, we proposed a statistically motivated
dual energy image reconstruction method - DE PWLS.
Advisors/Committee Members: Clinthorne, Neal H. (advisor), Fessler, Jeffrey A. (advisor).
Subjects/Keywords: Cone-beam Ct; Ct Scanner; Design; Dual Modality; Dual-modality; Feasibility; Flat-panel Detector; Flat-panel Detectors; Pet; Study
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APA (6th Edition):
Sukovic, P. (2003). Design of a dual modality PET/cone beam CT scanner. A feasibility study. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/123716
Chicago Manual of Style (16th Edition):
Sukovic, Predrag. “Design of a dual modality PET/cone beam CT scanner. A feasibility study.” 2003. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/123716.
MLA Handbook (7th Edition):
Sukovic, Predrag. “Design of a dual modality PET/cone beam CT scanner. A feasibility study.” 2003. Web. 15 Jan 2021.
Vancouver:
Sukovic P. Design of a dual modality PET/cone beam CT scanner. A feasibility study. [Internet] [Doctoral dissertation]. University of Michigan; 2003. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/123716.
Council of Science Editors:
Sukovic P. Design of a dual modality PET/cone beam CT scanner. A feasibility study. [Doctoral Dissertation]. University of Michigan; 2003. Available from: http://hdl.handle.net/2027.42/123716
University of Michigan
12.
Lee, Wonho.
A dual modality gamma camera using lanthanum chloride(cerium) scintillators.
Degree: PhD, Nuclear engineering, 2007, University of Michigan
URL: http://hdl.handle.net/2027.42/126761
► Portable gamma-ray imaging devices capable of responding to a broad energy range while providing reasonable angular resolution and efficiency are useful in a number of…
(more)
▼ Portable gamma-ray imaging devices capable of responding to a broad energy range while providing reasonable angular resolution and efficiency are useful in a number of applications, including environmental remediation and industrial surveys. Due to this, a
dual radiation imaging system that combines the advantages of a multi-aperture mechanical collimator with electronic-collimation has been designed, built, and tested. The combination of these two disparate imaging modalities offers both efficiency and good angular resolution, and is unique since a single gamma ray can contribute information to both modalities simultaneously. The mechanically collimated camera is most effective for imaging lower energy photons while electronic collimation uncouples spatial resolution from efficiency for higher energies. The
Dual Modality Gamma Camera (DMGC) combines a high-resolution URA coded aperture with a Compton scatter camera to provide a broader range of energy response suitable for a wider range of industrial applications (50keV-2MeV). The LaCl
3(Ce) in the first detector module has 22x22 voxels, each voxel having a dimension of 2x2x5mm
3. The LaCl
3(Ce) in the second detector module has 6x6 voxels having dimensions of 4x4x 10mm
3. Both scintillators are coupled to PSPMTs. For the front-end circuit of the first detector, a VaTa chip from IDEAS and a custom circuit are utilized and we compared images from both. Point and ring radiation sources (140, 364, 662 and 1275 keV) are simulated. The results show that the DMGC can cover a broad energy range of radiation and the combined
dual collimation image, using the maximum likelihood method for image reconstruction, yields better images than either a mechanical or an electronic collimation image at intermediate energies. Experimental results at the intermediate energies confirm that
dual collimation image outperforms a mechanical or an electronic collimation image.
Advisors/Committee Members: Wehe, David K. (advisor).
Subjects/Keywords: Ce; Cerium; Dual; Gamma Camera; Lacl3; Lanthanum Chloride; Modality; Scintillators; Using
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APA (6th Edition):
Lee, W. (2007). A dual modality gamma camera using lanthanum chloride(cerium) scintillators. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/126761
Chicago Manual of Style (16th Edition):
Lee, Wonho. “A dual modality gamma camera using lanthanum chloride(cerium) scintillators.” 2007. Doctoral Dissertation, University of Michigan. Accessed January 15, 2021.
http://hdl.handle.net/2027.42/126761.
MLA Handbook (7th Edition):
Lee, Wonho. “A dual modality gamma camera using lanthanum chloride(cerium) scintillators.” 2007. Web. 15 Jan 2021.
Vancouver:
Lee W. A dual modality gamma camera using lanthanum chloride(cerium) scintillators. [Internet] [Doctoral dissertation]. University of Michigan; 2007. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/2027.42/126761.
Council of Science Editors:
Lee W. A dual modality gamma camera using lanthanum chloride(cerium) scintillators. [Doctoral Dissertation]. University of Michigan; 2007. Available from: http://hdl.handle.net/2027.42/126761
13.
Wu, Ning.
Development and application of photoacoustic/ultrasound microscopy systems.
Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2017, Georgia Tech
URL: http://hdl.handle.net/1853/58697
► Development of biomedical microscopy largely promotes the research of life science and medicine. Emerging as a hybrid imaging technique, Photoacoustic (PA) microscopy (PAM) transfers the…
(more)
▼ Development of biomedical microscopy largely promotes the research of life science and medicine. Emerging as a hybrid imaging technique, Photoacoustic (PA) microscopy (PAM) transfers the absorbed light energy by intrinsic chromophores into heat, and induces ultrasonic signal. PAM combines the merits of optical high contrast and ultrasonic low scattering, which has been a new important
modality of biomedical optics microscopy, as well as shows significance for clinical research. Using transducer to detect the ultrasound, PAM has the potential to do ultrasound (US) imaging. Integrated the PA/US
dual-
modality microscopy can provide complementary information of pure optics imaging and US imaging.
Focusing on high resolution PA/US
dual-
modality imaging technique, this thesis has done a lot of work including theoretical analysis, simulation, system setup, phantom and small animal experiments. The major work and innovation include:
1. Developing a novel high resolution PA/US
dual-
modality microscopy, and realizing noninvasively in vivo small animal whole eye
dual-
modality imaging at the first time. The system developed in this thesis is capable to image microcirculatory system of living tissue, as well as provide US structure information.
2. Proposing a new design to use parabolic mirror in PA/US
dual-
modality microscopy, achieving the confocal effect of collimated light and parallel US. With parabolic mirror, the focusing length of laser and US is decreased largely, which improves the system resolution by the simple design. Combined with water-immersible microelectromechanical systems (MEMS) scanning mirror, this system can achieve a fast scanning speed.
3. Investigating the effect of transducer deflection angle on functional PAM accuracy, in off-axial PAM systems. With multiple wavelengths, PAM has the advantage to provide functional information, such as oxygen saturation (SO2). This thesis demonstrates that the oblique detection will lead to the inaccuracy of SO2 measurement severely, providing valuable guidance for the design of functional PAM.
4. Besides, this thesis introduces other two parts of work. One is continuing the PAM study. We explore the feasibility of a new PA contrast agent- DNA-templated silver nanocluster, and compare its PA signal with other organic dyes. In another work, we investigate the 2D kinetics by fluorescence correlation spectroscopy (FCS), demonstrating FCS is a potential method to study molecular mechanism of immunology pathway.
This thesis mainly contains five parts: Introduction part gives a brief idea about PAM background; The second and third chapter introduce the development and application of PA/US
dual-
modality microscopies; The forth chapter investigates the effect of oblique detection angle on functional PAM quantitative measurement; The fifth chapter introduces the study on new PA imaging contrast agent and molecular 2D kinetics by FCS; The last chapter gives the conclusion of whole thesis.
Advisors/Committee Members: Li, Changhui (advisor), Zhu, Cheng (advisor), Xi, Peng (committee member), Chen, Antony K. (committee member), Yang, Kun (committee member).
Subjects/Keywords: Biomedical microscopy; Photoacoustic microscopy; Photoacoustic/ultrasound dual-modality microscopy
…US) imaging. Integrated the PA/US dual-modality
microscopy can provide complementary… …information of pure optics imaging and US
imaging.
Focusing on high resolution PA/US dual-modality… …Developing a novel high resolution PA/US dual-modality microscopy, and
realizing noninvasively in… …vivo small animal whole eye dual-modality imaging at the first
time. The system developed in… …of
PA/US dual-modality microscopies; The forth chapter investigates the effect of oblique…
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APA ·
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APA (6th Edition):
Wu, N. (2017). Development and application of photoacoustic/ultrasound microscopy systems. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/58697
Chicago Manual of Style (16th Edition):
Wu, Ning. “Development and application of photoacoustic/ultrasound microscopy systems.” 2017. Doctoral Dissertation, Georgia Tech. Accessed January 15, 2021.
http://hdl.handle.net/1853/58697.
MLA Handbook (7th Edition):
Wu, Ning. “Development and application of photoacoustic/ultrasound microscopy systems.” 2017. Web. 15 Jan 2021.
Vancouver:
Wu N. Development and application of photoacoustic/ultrasound microscopy systems. [Internet] [Doctoral dissertation]. Georgia Tech; 2017. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/1853/58697.
Council of Science Editors:
Wu N. Development and application of photoacoustic/ultrasound microscopy systems. [Doctoral Dissertation]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/58697
University of Toledo
14.
Warrell, Gregory Ralph.
Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors.
Degree: PhD, Physics, 2016, University of Toledo
URL: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1462562122
► Hyperthermia has long been known as a radiation therapy sensitizer of high potential; however successful delivery of this modality and integrating it with radiation…
(more)
▼ Hyperthermia has long been known as a
radiation therapy sensitizer of high potential; however successful
delivery of this
modality and integrating it with radiation have
often proved technically difficult. We present the
dual-
modality
thermo-brachytherapy (TB) seed, based on the ubiquitous low
dose-rate (LDR) brachytherapy permanent implant, as a simple and
effective combination of hyperthermia and radiation therapy. Heat
is generated from a ferromagnetic or ferrimagnetic core within the
seed, which produces Joule heating by eddy currents. A
strategically-selected Curie temperature provides thermal
self-regulation. In order to obtain a uniform and sufficiently high
temperature distribution, additional hyperthermia-only (HT-only)
seeds are proposed to be used in vacant spots within the needles
used to implant the TB seeds; this permits a high seed density
without the use of additional
needles. Experimental and computational studies
were done both to optimize the design of the TB and HT-only seeds
and to quantitatively assess their ability to heat and irradiate
defined, patient-specific targets. Experiments were performed with
seed-sized ferromagnetic samples in tissue-mimicking phantoms
heated by an industrial induction heater. The magnetic and thermal
properties of the seeds were studied computationally in the finite
element analysis (FEA) solver COMSOL Multiphysics, modelling
realistic patient-specific seed distributions. This distributions
were derived from LDR permanent prostate implants previously
conducted at our institution; various modifications of the seeds'
design were studied. The calculated temperature distributions were
analyzed by generating temperature-volume histograms, which were
used to quantify coverage and temperature homogeneity for a range
of blood perfusion rates, as well as for a range of seed Curie
temperatures and thermal power production rates. The impact of the
interseed attenuation and scatter (ISA) effect on radiation dose
distributions of this seed was also quantified by Monte Carlo
studies in the software package
MCNP5. Experimental and computational analyses
agree that the proposed seeds may heat a defined target with safe
and attainable seed spacing and magnetic field parameters. These
studies also point to the use of a ferrite-based ferrimagnetic core
within the seeds, a design that would deliver hyperthermia of
acceptable quality even for the high rate of blood perfusion in
prostate tissue. The loss of radiation coverage due to the ISA
effect of distributions of TB and HT-only seeds may be rectified by
slightly increasing the prescribed dose in standard dose
superposition-based treatment planning
software. A systematic approach of combining LDR
prostate brachytherapy with hyperthermia is thus described, and its
ability to provide sufficient and uniform temperature distributions
in realistic patient-specific implants evaluated. Potential
improvements to the previously reported TB seed design are
discussed based on quantitative evaluation of its operation and…
Advisors/Committee Members: Shvydka, Diana (Advisor).
Subjects/Keywords: Physics; Medicine; Biophysics; thermo-brachytherapy, brachytherapy, hyperthermia,
dual-modality, self-regulating, blood perfusion, Curie temperature,
prostate carcinoma, prostate cancer, interseed effect, Monte Carlo,
finite element analysis
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APA (6th Edition):
Warrell, G. R. (2016). Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors. (Doctoral Dissertation). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1462562122
Chicago Manual of Style (16th Edition):
Warrell, Gregory Ralph. “Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors.” 2016. Doctoral Dissertation, University of Toledo. Accessed January 15, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1462562122.
MLA Handbook (7th Edition):
Warrell, Gregory Ralph. “Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors.” 2016. Web. 15 Jan 2021.
Vancouver:
Warrell GR. Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors. [Internet] [Doctoral dissertation]. University of Toledo; 2016. [cited 2021 Jan 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1462562122.
Council of Science Editors:
Warrell GR. Computational and Experimental Evaluations of a Novel
Thermo-Brachytherapy Seed for Treatment of Solid Tumors. [Doctoral Dissertation]. University of Toledo; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1462562122
University of South Florida
15.
Chen, Zhaohui.
The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions.
Degree: 2006, University of South Florida
URL: https://scholarcommons.usf.edu/etd/2478
► This dissertation investigated the effects of multimedia annotation on L2 vocabulary learning and reading comprehension. The overarching objective of this study was to compare the…
(more)
▼ This dissertation investigated the effects of multimedia annotation on L2 vocabulary learning and reading comprehension. The overarching objective of this study was to compare the effects of text-picture annotation and audio-picture annotation on L2 vocabulary immediate recall and reading comprehension. This study also sought to examine the different effects under incidental and intentional learning conditions. The participants were 78 intermediate adult ESL learners from three universities in northwest U.S. The participants read an Internet-based English text. Twenty target words, annotated in either text-picture or audio-picture, were embedded in the reading text. The participants accessed the annotations by clicking on the highlighted target words. Two instruments were used for measuring vocabulary immediate recall: Vocabulary Knowledge Scale and Word Recognition Test.
Two measurements were used to assess reading comprehension: Multiple-choice Reading Comprehension Questions and L1 Written Recall. In term of annotation types, the results indicated that the audio-picture annotation group did significantly better than the text-picture group in L2 vocabulary immediate recall. However, there was no significantly different effect between the two annotations on L2 reading comprehension. In terms of learning conditions, the intentional learning condition resulted in significantly better performance in L2 vocabulary immediate recall than the incidental learning condition. However, the incidental learning condition resulted in significantly better L2 reading comprehension than the intentional learning condition only in the Written Recall measure, but not in the multiple-choice Reading Comprehension Test.
In terms of interaction between annotation type and learning condition, there was not interaction between annotation type and learning condition on L2 vocabulary immediate recall. The interaction between annotation type and learning condition on L2 reading comprehension was not significant in multiple-choice Reading Comprehension Text. However, the interaction was found to be significant in Written Recall: in the incidental learning condition, the difference between text-picture annotation and audio-picture annotation was not significant; in the intentional learning condition, participants in text-picture did significantly better than those in audio-picture on Written Recall.
Subjects/Keywords: Cognitive; Modality; Attention; Look-up; Noticing; Task type; ESL; Dual-coding; American Studies; Arts and Humanities
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Manager
APA (6th Edition):
Chen, Z. (2006). The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/2478
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Zhaohui. “The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions.” 2006. Thesis, University of South Florida. Accessed January 15, 2021.
https://scholarcommons.usf.edu/etd/2478.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Zhaohui. “The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions.” 2006. Web. 15 Jan 2021.
Vancouver:
Chen Z. The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions. [Internet] [Thesis]. University of South Florida; 2006. [cited 2021 Jan 15].
Available from: https://scholarcommons.usf.edu/etd/2478.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen Z. The effects of multimedia annotations on L2 vocabulary immediate recall and reading comprehension: A comparative study of text-picture and audio-picture annotations under incidental and intentional learning conditions. [Thesis]. University of South Florida; 2006. Available from: https://scholarcommons.usf.edu/etd/2478
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Maryland
16.
Freed, Melanie.
A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols.
Degree: Bioengineering, 2010, University of Maryland
URL: http://hdl.handle.net/1903/11440
► The current clinical standard for breast cancer screening is mammography. However, this technique has a low sensitivity which results in missed cancers. Dynamic contrast-enhanced magnetic…
(more)
▼ The current clinical standard for breast cancer screening is mammography. However, this technique has a low sensitivity which results in missed cancers. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has recently emerged as a promising technique for breast cancer diagnosis and has been reported as being superior to mammography for screening of high-risk women and evaluation of extent of disease. At the same time, low and variable specificity has been documented in the literature as well as a rising number of mastectomies possibly due to the increasing use of DCE-MRI. In this study, we developed and characterized a
dual-
modality, x-ray and DCE-MRI, anthropomorphic breast phantom for the quantitative assessment of breast imaging protocols. X-ray properties of the phantom were quantitatively compared with patient data, including attenuation coefficients, which matched human values to within the measurement error, and tissue structure using spatial covariance matrices of image data, which were found to be similar in size to patient data. Simulations of the phantom scatter-to-primary ratio (SPR) were produced and experimentally validated then compared with published SPR predictions for homogeneous phantoms. SPR values were as high as 85% in some areas and were heavily influenced by the heterogeneous tissue structure. MRI properties of the phantom, T1 and T2 relaxation values and tissue structure, were also quantitatively compared with patient data and found to match within two error bars. Finally, a dynamic lesion that mimics lesion border shape and washout curve shape was included in the phantom. High spatial and temporal resolution x-ray measurements of the washout curve shape were performed to determine the true contrast agent concentration as a function of time. DCE-MRI phantom measurements using a clinical imaging protocol were compared against the x-ray truth measurements. MRI signal intensity curves were shown to be less specific to lesion type than the x-ray derived contrast agent concentration curves. This phantom allows, for the first time, for quantitative evaluation of and direct comparisons between x-ray and MRI breast imaging modalities in the context of lesion detection and characterization.
Advisors/Committee Members: Badano, Aldo (advisor).
Subjects/Keywords: Biomedical Engineering; Medical Imaging and Radiology; anthropomorphic; breast cancer; breast imaging; dual-modality; magnetic resonance imaging; x-ray
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APA (6th Edition):
Freed, M. (2010). A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/11440
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Freed, Melanie. “A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols.” 2010. Thesis, University of Maryland. Accessed January 15, 2021.
http://hdl.handle.net/1903/11440.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Freed, Melanie. “A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols.” 2010. Web. 15 Jan 2021.
Vancouver:
Freed M. A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols. [Internet] [Thesis]. University of Maryland; 2010. [cited 2021 Jan 15].
Available from: http://hdl.handle.net/1903/11440.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Freed M. A dual modality, DCE-MRI and x-ray, physical phantom for quantitative evaluation of breast imaging protocols. [Thesis]. University of Maryland; 2010. Available from: http://hdl.handle.net/1903/11440
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
18.
Bocti, John P.
The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial.
Degree: 2015, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/3187
► Cognitive decline disorders are becoming increasingly prevalent, with older adults at increased risk. Combined exercise has been recently explored as an intervention to help to…
(more)
▼ Cognitive decline disorders are becoming increasingly prevalent, with older adults at increased risk. Combined exercise has been recently explored as an intervention to help to prevent the decline, however cognitive activation in combination with physical activity has yet to be explored. Therefore, the purpose of the study is to determine the effects of multiple modality exercise programs in combination with a mind-motor task and their effects on mobility and cognitive variables. A total of (n=89) older adults (55+ yrs), with subjective cognitive complaints participated in a multiple modality exercise class, three days a week over six months, with the intervention group performing an additional mind-motor exercise. Significant differences were observed in gait variables, with not significant changes in balance or executive function. Multiple-Modality exercise with mind-motor training does yield physiological improvements as well as mobility
Subjects/Keywords: gait; balance; executive function; multiple modality; mind-motor; combined exercise; dual-task; single-task; cognition; exercise; subjective cognitive complaint; alzheimer's; dementia; SSE; cognitive activation; older adults; elderly; community dwelling; Alternative and Complementary Medicine; Community Health and Preventive Medicine; Exercise Physiology; Kinesiotherapy; Laboratory and Basic Science Research; Movement and Mind-Body Therapies; Other Rehabilitation and Therapy; Physical Therapy; Preventive Medicine; Public Health Education and Promotion; Recreational Therapy
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Record Details
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APA ·
Chicago ·
MLA ·
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CSE |
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Manager
APA (6th Edition):
Bocti, J. P. (2015). The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3187
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bocti, John P. “The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial.” 2015. Thesis, University of Western Ontario. Accessed January 15, 2021.
https://ir.lib.uwo.ca/etd/3187.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bocti, John P. “The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial.” 2015. Web. 15 Jan 2021.
Vancouver:
Bocti JP. The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Jan 15].
Available from: https://ir.lib.uwo.ca/etd/3187.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bocti JP. The Effect of a Multiple Modality Mind-Motor Exercise Intervention on Single and Dual-Task Gait, Balance, and Executive Function, in Community Dwelling Older Adults with a Subjective Cognitive Complaint: A Randomized Controlled Trial. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/3187
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
19.
Evans, Nathaniel Joseph.
Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load.
Degree: 2013, University of Tennessee – Knoxville
URL: https://trace.tennessee.edu/utk_graddiss/2421
► This study focused on parents of children between the ages of 7 to 11 and their ability to recognize and understand a children’s advergame as…
(more)
▼ This study focused on parents of children between the ages of 7 to 11 and their ability to recognize and understand a children’s advergame as advertising. Using the theoretical framework of the Persuasion Knowledge Model (PKM), this study experimentally tested the effects of advertising disclosures and cognitive load on parents’ activation of persuasion knowledge in children’s advergames and parents’ attitudes toward children’s advergames. In addition, this study examined how parents’ individual trait differences in persuasion knowledge and mediation of their children’s Internet use potentially influenced their persuasion knowledge in children’s advergames as well as their attitudes toward them. By conducting an online experiment (N = 202), the study revealed that: a) parents exposed to a single modality advertising disclosure reported significantly more selling and persuasion knowledge of children’s advergames compared to parents exposed to an advergame without an advertising disclosure; b) parents that experienced high(er) levels of cognitive load reported significantly less selling and persuasion knowledge of children’s advergames compared to parents that experienced low(er) levels of cognitive load; c) parents’ exposed to the dual modality advertising disclosure condition reported significantly less negative perceptions of children’s advergames compared to parents who were exposed to no advertising disclosure; c) as parents reported higher levels of trait persuasion knowledge, their associated reports of selling and persuasion knowledge within children’s advergames were lower. In addition to implications for prior and future applications of persuasion knowledge theory, managerial and practitioner implications are also provided.
Subjects/Keywords: Advergames; Parents; Persuasion Knowledge; Cognitive Load; Dual Modality; Disclosures; Advertising and Promotion Management; Communication Technology and New Media; Mass Communication; Other Psychology; Public Relations and Advertising
…loaded/ dual modality ad-disclosure condition €¦ €¦ €¦ €¦ €¦ €¦40
Figure 4. cognitively unloaded/ no… …ad-disclosure condition €¦ €¦ €¦ €¦ €¦.41
Figure 6. cognitively unloaded/ dual modality ad… …disclosure modality (single/dual) and CL (top 50%/no CL
treatment)… …intent with advergames (Evans et al., 2013).
Dual Modality Disclosures
As one of… …modality
disclosures compared to single modality disclosures. The use of dual modality…
Record Details
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Record Details
Similar Records
Cite
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Evans, N. J. (2013). Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load. (Doctoral Dissertation). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_graddiss/2421
Chicago Manual of Style (16th Edition):
Evans, Nathaniel Joseph. “Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load.” 2013. Doctoral Dissertation, University of Tennessee – Knoxville. Accessed January 15, 2021.
https://trace.tennessee.edu/utk_graddiss/2421.
MLA Handbook (7th Edition):
Evans, Nathaniel Joseph. “Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load.” 2013. Web. 15 Jan 2021.
Vancouver:
Evans NJ. Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load. [Internet] [Doctoral dissertation]. University of Tennessee – Knoxville; 2013. [cited 2021 Jan 15].
Available from: https://trace.tennessee.edu/utk_graddiss/2421.
Council of Science Editors:
Evans NJ. Activating Parents’ Persuasion Knowledge in Children’s Advergames: Testing the Effects of Advertising Disclosures and Cognitive Load. [Doctoral Dissertation]. University of Tennessee – Knoxville; 2013. Available from: https://trace.tennessee.edu/utk_graddiss/2421
. 
Open Access Theses and Dissertations
