subject:(Docosahexaenoic Acid)

Cornell University

1. Kachlishvili, Khatuna. Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids.

Degree: PhD, Chemistry and Chemical Biology, 2011, Cornell University

► The methylene-interrupted, all-cis (Z) bond configuration is overwhelmingly favored in polyunsaturated fatty acids (PUFA) of vertebrate membranes, particularly the highly unsaturated membranes of electrically-active neural… (more)

▼ The methylene-interrupted, all-cis (Z) bond configuration is overwhelmingly favored in polyunsaturated fatty acids (PUFA) of vertebrate membranes, particularly the highly unsaturated membranes of electrically-active neural tissue. The hypothesis that hexaene and pentaene homoallylic groups are sterically allowed to follow the groove of a transmembrane [alpha]-helix from bovine rhodopsin using energy minimization (EM) and molecular dynamics (MD) simulations with the GROMOS96 force field was investigated. Docosahexaenoic acid (22:6n-3) and docosapentaenoic acid (22:5n-6) were configured along arbitrary, mid-, top-helix paths along helix 2, with the doubly allylic hydrogens directed inward and the ethylenic hydrogens directed out of the helix. It was shown, by performing EM and MD simulations for 22:6n-3 and 22:5n-6, that the rotationally constrained homoallylic regions are more stably contained within the groove than saturated regions. The analyses of the initial conformations of 22:6n3 in phosphatidylcholine-22:6n-3/34:5n-3 and 22:5n-6 in phosphatidylcholine-22:5n6/34:5n-3, and of conformations of 22:6n-3 in phosphatidylcholine-22:6n-3/34:5n-3 obtained after EM showed that the homoallylic regions fit loosely within the groove while the saturated regions are much closer to the groove boundary. Calculations using a configuration with phosphatidylcholine-22:6n-3/34:5n-3 showed that the 22:6n-3 chain can follow the groove nearest a membrane-water interface, while the homoallylic region of the very long chain 34:5n-3 can follow the groove nearer the membrane center, tethered by its extended saturated region. These results illustrate that the homoallylic polyunsaturated fatty acid motif is not sterically restricted from occupying the groove of a transmembrane [alpha]-helix and provide a testable prediction. The biophysical stability and properties conferred by this configuration was speculated. Advisors/Committee Members: Brenna, James Thomas (chair), Scheraga, Harold A (committee member), Freed, Jack H (committee member).

Subjects/Keywords: Glycerophospholipids; Docosahexaenoic fatty acid; Docosapentaenoic fatty acid

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APA (6^th Edition):

Kachlishvili, K. (2011). Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/29374

Chicago Manual of Style (16^th Edition):

Kachlishvili, Khatuna. “Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids.” 2011. Doctoral Dissertation, Cornell University. Accessed February 28, 2021. http://hdl.handle.net/1813/29374.

MLA Handbook (7^th Edition):

Kachlishvili, Khatuna. “Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids.” 2011. Web. 28 Feb 2021.

Vancouver:

Kachlishvili K. Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1813/29374.

Council of Science Editors:

Kachlishvili K. Steric Effects In Interaction Between Transmembrane Proteins And Phospholipids. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/29374

Florida State University

2. Jenny, Christopher. Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis.

Degree: MS, Human Sciences, 2015, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_2015fall_Jenney_C_Thesis_2010_DateRedacted_Redacted ;

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As much as 10% of the US population will experience at least one bout of depression within their lifetime. It has been reported that an… (more)

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As much as 10% of the US population will experience at least one bout of depression within their lifetime. It has been reported that an increased time spent with major depressive disorder (MDD) results in a decreased volume in the hippocampus. This decreased volume is the result of apoptosis, or programmed cell death. In recent years it has become known that new neurons (neurogenesis) are continuously born in the hippocampus of humans. In fact, it now appears that antidepressant drug efficacy may be dependent on adult neurogenesis in the hippocampus. At least six epidemiological studies have shown an inverse correlation between seafood intake and prevalence of mood disorders (p [less than]0.05 or better). There is mounting evidence that this result is due to fish oils containing the long-chain, poly-unsaturated, omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Although extensive study has been undertaken using both of these omega-3s together, very little has been done to determine which fatty acid has the greater effect. Although previously thought to be readily interconvertible, there is mounting evidence that these two lipids are not treated equally in the body. EPA has produced greater cell proliferation over DHA in the B-lymphocyte cells, and DHA has even been known to cause a decrease at higher concentrations. Differences have also been reported in both molecular and behavioral outcomes. This research tested the hypothesis that EPA facilitates proliferation and survival of neuronal precursor cells to a greater extent than does DHA. Human neuronal precursor cells were grown in the presence of EPA, DHA, and varying ratios of EPA and DHA to determine their dose-response relationships. While there were no large effects on proliferation or differentiation, EPA, but not DHA, protected cells from iron-induced oxidative stress. This protection appears to be, at least in part, the result of altered p53 translocation in EPA-treated cells. Future work will be needed to determine the role of this molecular protection in the antidepressant activity of EPA.

A Dissertation submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science.

July 16, 2009.

Cathy Levenson, Professor Directing Theis; Jodee Dorsey, Committee Member; Michael Meredith, Committee Member.

Advisors/Committee Members: Cathy W. Levenson (professor directing thesis), Jodee L. Dorsey (committee member), Michael Meredith (committee member).

Subjects/Keywords: Eicosapentaenoic acid; Docosahexaenoic acid; Affective disorders

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APA (6^th Edition):

Jenny, C. (2015). Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_2015fall_Jenney_C_Thesis_2010_DateRedacted_Redacted ;

Chicago Manual of Style (16^th Edition):

Jenny, Christopher. “Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis.” 2015. Masters Thesis, Florida State University. Accessed February 28, 2021. http://purl.flvc.org/fsu/fd/FSU_2015fall_Jenney_C_Thesis_2010_DateRedacted_Redacted ;.

MLA Handbook (7^th Edition):

Jenny, Christopher. “Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis.” 2015. Web. 28 Feb 2021.

Vancouver:

Jenny C. Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis. [Internet] [Masters thesis]. Florida State University; 2015. [cited 2021 Feb 28]. Available from: http://purl.flvc.org/fsu/fd/FSU_2015fall_Jenney_C_Thesis_2010_DateRedacted_Redacted ;.

Council of Science Editors:

Jenny C. Differential Effects of Eicosaoentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Neurinal Precursor Cell Proliferation and Neurogenisis. [Masters Thesis]. Florida State University; 2015. Available from: http://purl.flvc.org/fsu/fd/FSU_2015fall_Jenney_C_Thesis_2010_DateRedacted_Redacted ;

Texas A&M University

3. Kolar, Satya Sree N. Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis.

Degree: PhD, Nutrition, 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-1586

► Docosahexaenoic acid (DHA, 22:6n-3) from fish oil, and butyrate, a short-chain fatty acid fiber-fermentation product, protect against colon tumorigenesis in part by coordinately inducing apoptosis.… (more)

▼ Docosahexaenoic acid (DHA, 22:6n-3) from fish oil, and butyrate, a short-chain fatty acid fiber-fermentation product, protect against colon tumorigenesis in part by coordinately inducing apoptosis. We have demonstrated that the combination of these two bioactive compounds demonstrates an enhanced ability to induce colonocyte apoptosis by potentiating mitochondrial lipid oxidation. In order to explore the potential involvement of intracellular Ca2+ in the pro-apoptotic effect of DHA and butyrate, young adult mouse colonocytes (YAMC) and human colonocytes (HCT-116: p53+/+ and p53- /-) were treated with DHA or linoleic acid (LA) for 72 h ± butyrate for the final 6, 12 or 24 h. Cytosolic and mitochondrial Ca2+ levels were measured using Fluo-4 and Rhod-2. In addition, IP3 pool, store-operated channel (SOC)-mediated changes and apoptosis were measured. DHA did not alter basal Ca2+ or apoptosis following 6 h butyrate cotreatment. In contrast, at 12 and 24 h, DHA and butyrate treated cultures exhibited a decrease in cytosolic Ca2+ and enhanced apoptosis compared to LA and butyrate. DHA and butyrate also increased the mitochondrial-to-cytosolic Ca2+ ratio at 6, 12 and 24 h. The accumulation of mitochondrial Ca2+ preceded the onset of apoptosis which increased only following 12 h of butyrate co-treatment. RU-360, a mitochondrial uniporter inhibitor, abrogated mitochondrial Ca2+ accumulation and also partially blocked apoptosis in DHA and butyrate co-treated cells. p53+/+ and p53-/- cells demonstrated similar data with respect to all parameters. Additionally, mitochondrial Ca2+ measurements were also made in rat primarycolonocyte- culture. Rats were fed semipurified diets containing either fish oil (a source of DHA) or corn oil (a source of LA), and colonic crypts were incubated in butyrate exvivo and mitochondrial Ca2+ was quantified. Crypts from rats fed fish oil incubated in butyrate exhibited an increase in the mitochondrial-to-cytosolic Ca2+ ratio compared to fish oil only. In summary, our results indicate for the first time that the combination of DHA and butyrate, compared to butyrate alone, further enhances apoptosis by additionally recruiting a p53-independent Ca2+-mediated intrinsic mitochondrial pathway. These data explain in part why fermentable fiber when combined with fish oil exhibits an enhanced ability to induce apoptosis and protect against colon tumorigenesis. Advisors/Committee Members: Chapkin, Robert S (advisor), Burghardt, Robert C (committee member), Lupton, Joanne R (committee member), Zoran, Mark J (committee member).

Subjects/Keywords: Docosahexaenoic acid; colonocyte

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APA (6^th Edition):

Kolar, S. S. N. (2009). Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-1586

Chicago Manual of Style (16^th Edition):

Kolar, Satya Sree N. “Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis.” 2009. Doctoral Dissertation, Texas A&M University. Accessed February 28, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-1586.

MLA Handbook (7^th Edition):

Kolar, Satya Sree N. “Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis.” 2009. Web. 28 Feb 2021.

Vancouver:

Kolar SSN. Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis. [Internet] [Doctoral dissertation]. Texas A&M University; 2009. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1586.

Council of Science Editors:

Kolar SSN. Docosahexaenoic acid and butyrate synergistically modulate intracellular calcium compartmentalization to induce colonocyte apoptosis. [Doctoral Dissertation]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1586

Texas A&M University

4. Dobson, Justin P. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.

Degree: PhD, Kinesiology, 2015, Texas A&M University

URL: http://hdl.handle.net/1969.1/161241

► Dietary docosahexaenoic acid (DHA) (22:6 n-3) has been linked to many health benefits in sedentary populations, positively altering lipid profiles and reducing inflammation. The prospective… (more)

▼ Dietary docosahexaenoic acid (DHA) (22:6 n-3) has been linked to many health benefits in sedentary populations, positively altering lipid profiles and reducing inflammation. The prospective impacts of DHA supplementation in an athletic population during intensive physical training are less clear. The first investigation describes inflammatory responses and the second describes lipid and lipoprotein responses during intensive physical training with DHA supplementation in football athletes. Sixty NCAA Division I football players (20 ± 1.5 years, 187.4 ± 6.1 cm, 105.7 ± 18.9 kg) were randomly assigned to 2 g•day^-1 DHA (n=28) or corn-oil placebo (n=32). Blood samples were collected at voluntary summer training (Summer), 30 days after Summer (Pre-camp), and 24 days after Pre-camp (Post-camp). Selected cytokines (multiplex assay), WBC, percent leukocytes, total cholesterol (TC), triglycerides (TG), LDL, HDL, IDL, and VLDL cholesterol (-C) and lipoprotein particles were analyzed. One sample t-tests (α=0.05) were used to assess differences in percent change of cytokine concentration, leukocyte concentration, lipoprotein concentration, particle numbers, and density at each time point; independent t-tests (α=0.05) were used for differences between groups at Summer. Eotaxin and monocyte chemoattractant protein-1 (MCP-1) elevations were significantly attenuated in the DHA group during preseason camp compared to Placebo (P < 0.05). Regulated on activation, normal T cell expressed and secreted (RANTES) was significantly elevated in both groups (P < 0.05); however, the percent change increase in the Placebo group was 2-fold that of the DHA group. White blood cell counts decreased at Post-camp (P < 0.05) in both groups. Pre-camp percent change TG was significantly (P < 0.05) increased only in the Placebo group. Post-camp percent change TG and HDL particle number in the DHA group was significantly (P < 0.05) reduced. LDL4 number significantly increased in the DHA group (Post-camp, P < 0.05), and the Placebo group decreased in LDL-C (Pre-camp, P < 0.05). Both groups had increased HDL2b-C and HDL2a-C at Pre-camp (P<0.05). Pre-camp LDL3-C and Post-camp LDL4-C increased in the DHA group (P<0.05). RLP-C increased in the Placebo group (Pre-camp, P<0.05). Pre-camp HDL density and Post-camp LDL density decreased in the Placebo group. The DHA group decreased HDL density during preseason, but LDL density remained constant. Summer IDL-C was significantly (P < 0.05) higher in the DHA group. Percent change VLDL number was significantly (P < 0.05) increased during preseason camp. There was no difference in lipoprotein-a and C-reactive protein between groups. TC, HDL-C, and RLP number did not change over time nor differ between groups. Pre-camp homocysteine increased, while Post-camp insulin significantly (P < 0.05) decreased in the DHA group. These investigations further our knowledge of a particular omega-3 fatty acid (DHA) as a potential lipid mediator to mitigate cardiovascular risk, as well as an inflammatory modulator for possible… Advisors/Committee Members: Crouse, Stephen F (advisor), Fluckey, James D (committee member), Riechman, Steven E (committee member), Smith, Stephen B (committee member).

Subjects/Keywords: Docosahexaenoic Acid; Inflammation, Lipids; Lipoproteins; Football

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APA (6^th Edition):

Dobson, J. P. (2015). Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161241

Chicago Manual of Style (16^th Edition):

Dobson, Justin P. “Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.” 2015. Doctoral Dissertation, Texas A&M University. Accessed February 28, 2021. http://hdl.handle.net/1969.1/161241.

MLA Handbook (7^th Edition):

Dobson, Justin P. “Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.” 2015. Web. 28 Feb 2021.

Vancouver:

Dobson JP. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1969.1/161241.

Council of Science Editors:

Dobson JP. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/161241

Penn State University

5. Skibinski, Christine G. preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention.

Degree: 2015, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/26720

► As discussed in Chapter 1, Breast cancer is the second leading cause of cancer death in women in the United States, with about 2 million… (more)

▼ As discussed in Chapter 1, Breast cancer is the second leading cause of cancer death in women in the United States, with about 2 million women at high risk for developing the disease. A current strategy, approved by the FDA, for breast cancer prevention is the daily administration of selective estrogen receptor modulators(SERMS), tamoxifen and raloxifene. These SERMS have proven to be effective at reducing breast cancer incidence in women that are at high risk by 50% and 38%, respectively. However, these agents are poorly accepted as oral chemopreventives even by women at high risk for breast cancer because of concerns of side effects which include thromboembolic events and an increase in endometrial cancers. Furthermore, both agents are ineffective against the more aggressive estrogen receptor negative tumors. A series of experiments have been conducted in our laboratories to test the hypothesis that chemoprevention can be improved by combining SERMS with agents with different mechanisms of action. Such an approach can allow the use of low doses of SERMS and thus reduce their side effects. Literature data provide some support of the protective effects of omega-3 fatty acids against the development of several cancers, including breast cancer. However, the results remain inconsistent which could be due to confounding variables. These confounding variables which have been reported by our group include omega-3:omega-6(n-3:n-6) ratio and caloric intake. A previous study conducted in our laboratories showed that high ratios of omega-3:omega-6 fatty acids(25:1 n-3:n-6) are required to inhibit mammary carcinogenesis in the rat and such high ratios of omega-3:omega-6 fatty acids potentiated the chemopreventive efficacy of tamoxifen. Studies conducted in Chapter 2 were aimed to test the hypothesis that by using a proteomics approach, novel proteins can be identified that can provide insights into the molecular mechanism by which high ratios of omega-3:omega-6 fatty acids inhibit mammary carcinogenesis. We further hypothesize that proteins identified in a minimally invasive fashion can be used for early detection and to monitor the efficacy of the chemopreventive agents. We used an isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) method to provide insights into the mechanism, at the protein level, responsible for the chemopreventive action of the high omega-3:omega-6 fatty acid ratios in the absence and presence of tamoxifen in the 1-methyl-1-nitrosourea(MNU)-induced mammary tumor model in the rat; selective proteins were further validated by western blotting. Compared to control (n-3:n-6, 1:1) diet, both 10:1 and 25:1 n-3:n-6 diets upregulated plasma vitamin D binding protein, gelsolin, and 14-3-3 sigma, reported to have tumor suppressive effects, whereas alpha-1B-glycoprotein which has been reported to be elevated in the serum of breast cancer patients was decreased. Compared to 25:1 n-3:n-6, the 25:1 n-3:n-6 plus tamoxifen diet downregulated apolipoprotein E, haptoglobin, and… Advisors/Committee Members: Karam E El Bayoumy, Dissertation Advisor/Co-Advisor, Arunangshu Das, Committee Member, Thomas E Spratt, Committee Member, Andrea Manni, Committee Member, Mark Kester, Committee Member.

Subjects/Keywords: Docosahexaenoic Acid; Liposome; Breast Cancer Prevention

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APA (6^th Edition):

Skibinski, C. G. (2015). preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/26720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Skibinski, Christine G. “preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention.” 2015. Thesis, Penn State University. Accessed February 28, 2021. https://submit-etda.libraries.psu.edu/catalog/26720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Skibinski, Christine G. “preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention.” 2015. Web. 28 Feb 2021.

Vancouver:

Skibinski CG. preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Feb 28]. Available from: https://submit-etda.libraries.psu.edu/catalog/26720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Skibinski CG. preclinical investigations into the role of omega-3 fatty acids for breast cancer prevention. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/26720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

6. Trepanier, Marc-Olivier. The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents.

Degree: 2011, University of Toronto

URL: http://hdl.handle.net/1807/31611

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Introduction: One potential new therapy for epilepsy involves the omega-3 polyunsaturated fatty acids (PUFAs), and more specifically docosahexaenoic acid (DHA). Methods: The anticonvulsant properties… (more)

Subjects/Keywords: epilepsy; omega-3; docosahexaenoic acid; seizures; 0419

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Trepanier, M. (2011). The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/31611

Chicago Manual of Style (16^th Edition):

Trepanier, Marc-Olivier. “The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents.” 2011. Masters Thesis, University of Toronto. Accessed February 28, 2021. http://hdl.handle.net/1807/31611.

MLA Handbook (7^th Edition):

Trepanier, Marc-Olivier. “The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents.” 2011. Web. 28 Feb 2021.

Vancouver:

Trepanier M. The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1807/31611.

Council of Science Editors:

Trepanier M. The Anticonvulsant Effects of Docosahexaenoic Acid in Rodents. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31611

University of Wollongong

7. Hancock, Sarah E. Investigating changes in human brain phospholipids during normal ageing.

Degree: PhD, 2015, University of Wollongong

URL: ; https://ro.uow.edu.au/theses/4624

► The world’s population is rapidly ageing, and with that has come a corresponding increase in the number of people suffering age-related diseases. Dementia is… (more)

▼ The world’s population is rapidly ageing, and with that has come a corresponding increase in the number of people suffering age-related diseases. Dementia is a group of age-related neurocognitive disorders, with the most common of these being Alzheimer’s disease (AD). The number one risk factor for developing AD is advanced age, with the incidence rising from 1 in 10,000 at age 60 to 1 in 3 by age 85. AD is characterised by the deposition of extracellular amyloid-β aggregates (Aβ) and intracellular neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau. Both Aβ and NFTs spread throughout the brain by separate but predictable pathways during the progression of the disease. Many studies have shown an involvement of membrane lipids, including phospholipids, in the pathogenesis of AD. Less is known about the changes occurring in membrane lipids such as phospholipids within the brain over the normal adult lifespan. Lipids are major components of the brain comprising 40-55% of the dry matter present, with phospholipids making up half of total brain lipid. The human brain undergoes a number of structural changes during the course of ageing that could theoretically lead to alterations in brain phospholipids. Changes to phospholipids with age within the human brain could be driven by two current theories of ageing: i) the mitochondrial free radical oxidative stress theory of ageing, which proposes that ageing is driven by damage to macromolecules such as lipids by reactive oxygen species produced by the mitochondria; or ii) the “inflammageing” theory, which suggests that ageing is driven by chronic, low-grade inflammation over the lifetime of an organism. Several studies conducted over twenty years ago attempted to characterise any changes occurring to brain phospholipids with age, but newer methods utilising mass spectrometry to identify and quantify lipids have become available since then. Understanding the changes occurring to phospholipids during normal ageing may lead to a better interpretation of the changes occurring during AD while also clarifying what fundamental mechanism underpins ageing within the human brain.

Subjects/Keywords: Lipids; docosahexaenoic acid; mitochondria; neurodegeneration; mass spectrometry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hancock, S. E. (2015). Investigating changes in human brain phospholipids during normal ageing. (Doctoral Dissertation). University of Wollongong. Retrieved from ; https://ro.uow.edu.au/theses/4624

Chicago Manual of Style (16^th Edition):

Hancock, Sarah E. “Investigating changes in human brain phospholipids during normal ageing.” 2015. Doctoral Dissertation, University of Wollongong. Accessed February 28, 2021. ; https://ro.uow.edu.au/theses/4624.

MLA Handbook (7^th Edition):

Hancock, Sarah E. “Investigating changes in human brain phospholipids during normal ageing.” 2015. Web. 28 Feb 2021.

Vancouver:

Hancock SE. Investigating changes in human brain phospholipids during normal ageing. [Internet] [Doctoral dissertation]. University of Wollongong; 2015. [cited 2021 Feb 28]. Available from: ; https://ro.uow.edu.au/theses/4624.

Council of Science Editors:

Hancock SE. Investigating changes in human brain phospholipids during normal ageing. [Doctoral Dissertation]. University of Wollongong; 2015. Available from: ; https://ro.uow.edu.au/theses/4624

Montana State University

8. Keithly, Jennifer Irene. Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid.

Degree: MS, College of Agriculture, 2010, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/1616

► Neonatal lamb mortality is a major factor effecting profitability in the sheep industry. Lamb thermogenesis and immunocompetence are key elements in neonatal lamb survival. Research… (more)

▼ Neonatal lamb mortality is a major factor effecting profitability in the sheep industry. Lamb thermogenesis and immunocompetence are key elements in neonatal lamb survival. Research has shown an increase in lamb vigor, when ewes were supplemented during late gestation with algae-derived docosahexaenoic acid (DHA). However, the impact of DHA on lamb thermogenesis and immunocompetence has not been investigated. Eighty twin-bearing Targhee ewes were assigned randomly to 1 of 2 supplemental treatments to determine the effects of feeding (DHA) to ewes during late gestation and early lactation on lamb thermogenesis, immunocompetence, serum metabolites and hormones, and lamb growth. Treatments within supplements were: 1) 12 g/ewe daily of the product DHA Gold in the form of algal biomass (ALGAE), and 2) no DHA (CONTROL). Treatment supplements were individually fed daily during the last 30 d of gestation and pen fed (6 pens/treatment, and 6 or 7 ewes/pen) during the first 38 d of lactation. One h after lambing and before nursing, twin-born lambs were weighed, bled via jugular puncture, and placed in a dry cold chamber for 30 min (0°C). Lamb rectal temperatures were recorded every 1 min. After 30 min, lambs were removed from the cold chamber, bled, warmed for 15 min, and returned to their dam. Ewes were bled and colostrum samples collected 1 h postpartum. Ewe and lamb sera were assayed for glucose, non-esterified fatty acids (NEFA), cortisol, leptin and anti-Parainfluenza Type 3 (PI³) titers. Lamb rectal temperature, glucose, NEFA, cortisol, leptin, anti-PI³ titers, and birth weights did not differ between treatments. Thirty-eight-d BW was greater (P = 0.03) in lambs born to CONTROL-supplemented than lambs born to ALGAE-supplemented ewes; however, the colostrum of ALGAE-supplemented ewes had a greater specific gravity (P = 0.05), indicating greater IgG concentrations, than colostrum of CONTROL-supplemented ewes. Supplementation of DHA during late gestation and early lactation had a negative impact on lamb BW and did not affect indices of lamb thermogenesis, but may have improved IgG concentrations in ewe colostrum. Advisors/Committee Members: Chairperson, Graduate Committee: Patrick G. Hatfield. (advisor).

Subjects/Keywords: Lambs.; Docosahexaenoic acid.

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APA (6^th Edition):

Keithly, J. I. (2010). Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid. (Masters Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/1616

Chicago Manual of Style (16^th Edition):

Keithly, Jennifer Irene. “Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid.” 2010. Masters Thesis, Montana State University. Accessed February 28, 2021. https://scholarworks.montana.edu/xmlui/handle/1/1616.

MLA Handbook (7^th Edition):

Keithly, Jennifer Irene. “Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid.” 2010. Web. 28 Feb 2021.

Vancouver:

Keithly JI. Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid. [Internet] [Masters thesis]. Montana State University; 2010. [cited 2021 Feb 28]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/1616.

Council of Science Editors:

Keithly JI. Thermogenesis, serum metabolites and hormones, and growth in lambs born to ewes supplemented with docosahexaenoic acid. [Masters Thesis]. Montana State University; 2010. Available from: https://scholarworks.montana.edu/xmlui/handle/1/1616

Louisiana State University

9. Shaw, Ann Hardin. Pregnancy and the relationship to age-related macular degeneration.

Degree: MS, Human Ecology, 2011, Louisiana State University

URL: etd-01122012-174758 ; https://digitalcommons.lsu.edu/gradschool_theses/1895

► The Macular Study was a case control study that evaluated if parity and other participant characteristics predicted the diagnosis of age-related macular degeneration (AMD). Women,… (more)

▼ The Macular Study was a case control study that evaluated if parity and other participant characteristics predicted the diagnosis of age-related macular degeneration (AMD). Women, compared to men, are at higher risk for AMD. AMD is one of the leading causes of blindness in the elderly population [1]. Docosahexaenoic acid (DHA, 22:6n-3) is a long-chain fatty acid that is essential for the structure and function of the eye. During pregnancy the growing fetus depletes the maternal stores of DHA through placental transfer. The fetus needs an ample supply of DHA for proper retinal and central nervous system development. To date there is no research evaluating the number of pregnancies and their effect on development of AMD. We posed the question: “Does the number of pregnancies have an effect on the development of AMD in women?” Degree of AMD was documented and evaluated by four different eye doctors in Baton Rouge for 501 women. The women in the study completed a health history form that included demographic information, information about past pregnancies, and general health. Using analysis of variance (ANOVA), women with a higher number of births were more likely to be diagnosed with early, intermediate or advanced AMD versus those women never diagnosed (3.27 + 0.19, 3.64 + 0.22, 3.33 + 0.24 versus 2.53 + 0.15, number of children P<0.0001). Numerous risk factors were considered, along with parity, in subsequent analyses; these were age, race, eye color, smoking history, vitamin intake, fish oil intake, family history of AMD, history of hypertension, and body mass index (BMI). Using backwards-stepwise regression the most significant risk factors predicting the diagnosis of AMD were determined (P < 0.01) and entered into a logistic regression model. Age, parity, BMI, and BMI by parity significantly predicted the diagnosis of AMD. As age, BMI and the number of pregnancies increased, the probability of being diagnosed with AMD also increased. In conclusion, older women, with a higher BMI, who have had more pregnancies, were more likely to have AMD compared to younger women with a lower BMI and fewer pregnancies. It is important that future studies consider parity as a possible risk for AMD, especially as it relates to other participant characteristics. Such studies may provide insight as to why women are at greater risk for AMD.

Subjects/Keywords: pregnancy; fish oil; macular degeneration; docosahexaenoic acid

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APA (6^th Edition):

Shaw, A. H. (2011). Pregnancy and the relationship to age-related macular degeneration. (Masters Thesis). Louisiana State University. Retrieved from etd-01122012-174758 ; https://digitalcommons.lsu.edu/gradschool_theses/1895

Chicago Manual of Style (16^th Edition):

Shaw, Ann Hardin. “Pregnancy and the relationship to age-related macular degeneration.” 2011. Masters Thesis, Louisiana State University. Accessed February 28, 2021. etd-01122012-174758 ; https://digitalcommons.lsu.edu/gradschool_theses/1895.

MLA Handbook (7^th Edition):

Shaw, Ann Hardin. “Pregnancy and the relationship to age-related macular degeneration.” 2011. Web. 28 Feb 2021.

Vancouver:

Shaw AH. Pregnancy and the relationship to age-related macular degeneration. [Internet] [Masters thesis]. Louisiana State University; 2011. [cited 2021 Feb 28]. Available from: etd-01122012-174758 ; https://digitalcommons.lsu.edu/gradschool_theses/1895.

Council of Science Editors:

Shaw AH. Pregnancy and the relationship to age-related macular degeneration. [Masters Thesis]. Louisiana State University; 2011. Available from: etd-01122012-174758 ; https://digitalcommons.lsu.edu/gradschool_theses/1895

University of Missouri – Columbia

10. Jasarevic, Eldin. The role of docosahexaenoic acid in stress reprogramming and behavior.

Degree: 2014, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/45906

► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The role of DHA (Docosahexaenoic acid [22:6(n-3)]) is known to play an important role in… (more)

Subjects/Keywords: Docosahexaenoic acid; Stress (Psychology); Pregnancy – Nutritional aspects

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APA (6^th Edition):

Jasarevic, E. (2014). The role of docosahexaenoic acid in stress reprogramming and behavior. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/45906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jasarevic, Eldin. “The role of docosahexaenoic acid in stress reprogramming and behavior.” 2014. Thesis, University of Missouri – Columbia. Accessed February 28, 2021. http://hdl.handle.net/10355/45906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jasarevic, Eldin. “The role of docosahexaenoic acid in stress reprogramming and behavior.” 2014. Web. 28 Feb 2021.

Vancouver:

Jasarevic E. The role of docosahexaenoic acid in stress reprogramming and behavior. [Internet] [Thesis]. University of Missouri – Columbia; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10355/45906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jasarevic E. The role of docosahexaenoic acid in stress reprogramming and behavior. [Thesis]. University of Missouri – Columbia; 2014. Available from: http://hdl.handle.net/10355/45906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

11. Berryman, Kevin Thomas. Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids.

Degree: MS, Department of Process Engineering and Applied Science, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15834

► The aim of this research was to isolate and characterize novel strains of marine protists with potential to commercially produce PUFAs. Twelve trips were made… (more)

Subjects/Keywords: Protist; Thraustochytrid; Polyunsaturated fatty acid; PUFA; DHA; Docosahexaenoic acid

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APA (6^th Edition):

Berryman, K. T. (2012). Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15834

Chicago Manual of Style (16^th Edition):

Berryman, Kevin Thomas. “Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids.” 2012. Masters Thesis, Dalhousie University. Accessed February 28, 2021. http://hdl.handle.net/10222/15834.

MLA Handbook (7^th Edition):

Berryman, Kevin Thomas. “Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids.” 2012. Web. 28 Feb 2021.

Vancouver:

Berryman KT. Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10222/15834.

Council of Science Editors:

Berryman KT. Isolation of Marine Protists for Production of Polyunsaturated Fatty Acids. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15834

University of Manitoba

12. Gabbs, Melissa. ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females.

Degree: Human Nutritional Sciences, 2015, University of Manitoba

URL: http://hdl.handle.net/1993/32141

► Time course changes in oxylipin profiles among healthy, young individuals consuming high doses of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) remain to be determined.… (more)

Subjects/Keywords: Oxylipin; Docosahexaenoic acid; Alpha-linolenic acid; Omega-3

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APA (6^th Edition):

Gabbs, M. (2015). ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32141

Chicago Manual of Style (16^th Edition):

Gabbs, Melissa. “ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females.” 2015. Masters Thesis, University of Manitoba. Accessed February 28, 2021. http://hdl.handle.net/1993/32141.

MLA Handbook (7^th Edition):

Gabbs, Melissa. “ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females.” 2015. Web. 28 Feb 2021.

Vancouver:

Gabbs M. ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females. [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1993/32141.

Council of Science Editors:

Gabbs M. ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females. [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/32141

University of Georgia

13. Li, Ruoyu. Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula.

Degree: 2015, University of Georgia

URL: http://hdl.handle.net/10724/31461

► In this study, refined olive oil was enriched with palmitic acid (PA) and docosahexaenoic acid (DHA) as well as gamma-linolenic acid (GLA) by lipase-catalyzed reaction… (more)

Subjects/Keywords: Refined olive oil; docosahexaenoic acid; palmitic acid; structured lipids.

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APA (6^th Edition):

Li, R. (2015). Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/31461

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Ruoyu. “Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula.” 2015. Thesis, University of Georgia. Accessed February 28, 2021. http://hdl.handle.net/10724/31461.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Ruoyu. “Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula.” 2015. Web. 28 Feb 2021.

Vancouver:

Li R. Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula. [Internet] [Thesis]. University of Georgia; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10724/31461.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li R. Olive oil-based structured lipids containing palmitic, omega-3 and -6 fatty acids for potential application in infant formula. [Thesis]. University of Georgia; 2015. Available from: http://hdl.handle.net/10724/31461

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

14. Teichert, Sarah Ann. Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/27835

► Human milk fat analogs are used in infant formula to mimic the fat found in human breast milk. The purpose of this research was to… (more)

Subjects/Keywords: Docosahexaenoic acid; Gamma-linolenic acid; Human milk fat analog; Palmitic acid; Stearidonic acid soybean oil

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APA (6^th Edition):

Teichert, S. A. (2014). Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/27835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Teichert, Sarah Ann. “Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula.” 2014. Thesis, University of Georgia. Accessed February 28, 2021. http://hdl.handle.net/10724/27835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Teichert, Sarah Ann. “Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula.” 2014. Web. 28 Feb 2021.

Vancouver:

Teichert SA. Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10724/27835.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Teichert SA. Enhancement of stearidonic acid soybean oil with palmitic acid and docosahexaenoic or gamma-linolenic acids for use as human milk fat analogs in infant formula. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/27835

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

15. Njoroge, Sarah Wanjiku. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.

Degree: PhD, Pathology, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/13122

► Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Alterations in polyunsaturated fatty acid (PUFA)… (more)

Subjects/Keywords: docosahexaenoic acid; arachidonic acid; desaturase enzymes; reactive oxygen species; Cystic fibrosis fatty acid abnormalities

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APA (6^th Edition):

Njoroge, S. W. (2013). Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13122

Chicago Manual of Style (16^th Edition):

Njoroge, Sarah Wanjiku. “Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/13122.

MLA Handbook (7^th Edition):

Njoroge, Sarah Wanjiku. “Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.” 2013. Web. 28 Feb 2021.

Vancouver:

Njoroge SW. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/13122.

Council of Science Editors:

Njoroge SW. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/13122

Northeastern University

16. Sonti, Shilpa. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).

Degree: PhD, School of Pharmacy, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20240140

► The metabolite of docosahexaenoic acid (DHA), synaptamide, is reported to mediate the role of DHA in neuritogenesis and synaptogenesis. Our long term goal is to… (more)

Subjects/Keywords: anandamide; arachidonic acid; docosahexaenoic acid; fatty acid amide hydrolase (faah); n27 cells; phospholipid

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APA (6^th Edition):

Sonti, S. (2016). Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20240140

Chicago Manual of Style (16^th Edition):

Sonti, Shilpa. “Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).” 2016. Doctoral Dissertation, Northeastern University. Accessed February 28, 2021. http://hdl.handle.net/2047/D20240140.

MLA Handbook (7^th Edition):

Sonti, Shilpa. “Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).” 2016. Web. 28 Feb 2021.

Vancouver:

Sonti S. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2047/D20240140.

Council of Science Editors:

Sonti S. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20240140

17. Ehr, Isa J. Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation.

Degree: 2017, Iowa State University

URL: https://lib.dr.iastate.edu/etd/17180

► Omega-3 fatty acids, specifically alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are known for possessing anti-inflammatory and bone modulating properties in murine… (more)

▼ Omega-3 fatty acids, specifically alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are known for possessing anti-inflammatory and bone modulating properties in murine and in vitro models. Health conscious consumers have created market demand for value-added omega-3 fatty acid enriched food, as demonstrated by the fact that specialty eggs make up 26.4% of the shell egg market. This has led producers to supplement poultry diets to create enriched eggs and meats and satisfy consumer demand. Thus far, omega-3 fatty acid research has primarily focused on creating value-added foods for the consumer with little attention paid to the effects of supplementation on the animals. The overarching goal of this dissertation research was to investigate the potential positive effects related to poultry health of dietary omega-3 fatty acid supplementation as a secondary benefit for producers. Two models were used to pursue the overarching goal: aged hens with mature immune systems at risk of osteoporosis and growing broilers with naïve immune systems prone to leg bone pathology. The experimental objectives of this dissertation were as follows: 1) Evaluate how dietary ALA sources affect the fatty acid transfer rate from laying hen diet to the egg yolk; 2) Determine if dietary supplementation of ALA or the combination of EPA and DHA improves performance and bone health of aged laying hens and whether protective anti-inflammatory effects would be exerted during acute inflammation; 3) Investigate if dietary supplementation of ALA or EPA and DHA impact bone health and performance in growing broilers, and 4) Examine the protective anti-inflammatory and bone modulating effects of ALA or EPA and DHA on broiler performance and health during a period of repeated inflammation. To evaluate dietary ALA sources and their fatty acid transfer rate to egg yolk (Objective 1, Experiment 1), diets supplemented with flaxseed oil or ground flaxseed were fed to Hy-Line W-36 laying hens near peak production for 8 wk. Egg yolk fatty acid profiles were measured to determine the transfer rates for the ALA sources. To determine if ALA or EPA and DHA affect bone health and inflammatory status of aged hens (Objective 2, Experiment 2), near end-of-second-cycle laying hens (122 to 134 wk of age) were fed diets supplemented with flaxseed oil or fish oil for 12 wk, followed by an acute lipopolysaccharide (LPS) inflammatory challenge. During the 12 wk dietary supplementation period, feed intake (FI), egg production, and egg weight were measured; and eggs and tibia were measured for strength prior to the inflammatory challenge. Liver inflammatory gene expression was measured 12 h post-LPS challenge. To investigate if ALA or EPA and DHA affect the bone health and performance of growing Ross 308 broilers (Objective 3, Experiment 3), diets supplemented with flaxseed oil or fish oil were fed for 28 consecutive d. FI, body weight (BW), breast yield, lameness, and bone mineral content (BMC) and density (BMD) were evaluated. Finally, to…

Subjects/Keywords: alpha-linolenic acid; bone health; docosahexaenoic acid; eicosapentaenoic acid; inflammation; Agriculture; Animal Sciences

12 more images…

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APA (6^th Edition):

Ehr, I. J. (2017). Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ehr, Isa J. “Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation.” 2017. Thesis, Iowa State University. Accessed February 28, 2021. https://lib.dr.iastate.edu/etd/17180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ehr, Isa J. “Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation.” 2017. Web. 28 Feb 2021.

Vancouver:

Ehr IJ. Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation. [Internet] [Thesis]. Iowa State University; 2017. [cited 2021 Feb 28]. Available from: https://lib.dr.iastate.edu/etd/17180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ehr IJ. Production and health responses of laying hens and growing broilers to dietary omega-3 fatty acid supplementation. [Thesis]. Iowa State University; 2017. Available from: https://lib.dr.iastate.edu/etd/17180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Venu Gopal, S K. Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -.

Degree: Botany, 2008, INFLIBNET

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35375

None

Reference p.200 - 221

Advisors/Committee Members: Mehta, Archana and Somal Priti.

Subjects/Keywords: Bioproduction; docosahexaenoic acid; marine protist

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APA (6^th Edition):

Venu Gopal, S. K. (2008). Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Venu Gopal, S K. “Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -.” 2008. Thesis, INFLIBNET. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/35375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Venu Gopal, S K. “Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -.” 2008. Web. 28 Feb 2021.

Vancouver:

Venu Gopal SK. Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -. [Internet] [Thesis]. INFLIBNET; 2008. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35375.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Venu Gopal SK. Bioproduction of docosahexaenoic acid by the marine protist schizochytrium; -. [Thesis]. INFLIBNET; 2008. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35375

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

19. Kaur, Gunveen. Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression.

Degree: School of Exercise and Nutrition Sciences, 2010, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30032365

This thesis found that the omega-3 fatty acid, docosapentaenoic acid (DPA) down-regulates the expression levels of key lipogenic genes and proteins in vitro. In vivo studies with labelled DPA showed that, like docosahexaenoic acid, DPA is more conserved from oxidation compared with eicosapentaenoic acid. Advisors/Committee Members: Sinclair, Andy.

Subjects/Keywords: Docosahexaenoic acid; Metabolism; Physiological effect; Omega-3 fatty acids

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APA (6^th Edition):

Kaur, G. (2010). Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30032365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kaur, Gunveen. “Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression.” 2010. Thesis, Deakin University. Accessed February 28, 2021. http://hdl.handle.net/10536/DRO/DU:30032365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kaur, Gunveen. “Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression.” 2010. Web. 28 Feb 2021.

Vancouver:

Kaur G. Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression. [Internet] [Thesis]. Deakin University; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10536/DRO/DU:30032365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kaur G. Docosapentaenoic acid : its metabolism and effect on lipogenic gene expression. [Thesis]. Deakin University; 2010. Available from: http://hdl.handle.net/10536/DRO/DU:30032365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queen Mary, University of London

20. Liu, Zhuo-Hao. Mechanisms and novel therapies in cervical spinal cord injury.

Degree: PhD, 2015, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12862 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775157

► Recent epidemiological data indicate that more than half of SCI patients have injuries of the cervical spine. There is no satisfactory treatment for these injuries… (more)

▼ Recent epidemiological data indicate that more than half of SCI patients have injuries of the cervical spine. There is no satisfactory treatment for these injuries either in the acute or the chronic phase. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid that is essential in brain development and has structural and signalling roles. Acute DHA administration has been shown to improve neurological functional recovery following injury in rodent thoracic spinal cord injury (SCI) animal models. In this thesis, we characterized a cervical SCI model comprising a hemisection lesion applied at the C4-5 level of the rat spinal cord, and tested the effects of an acute treatment with 250 nmol/kg DHA delivered intravenously 30 minutes after injury. The acute intravenous bolus of DHA not only increased the number of neuronal cells spared at three weeks following injury but also resulted in robust sprouting of uninjured corticospinal and serotonergic fibres. Next, we used a mouse pyramidotomy model to confirm that this robust sprouting was not species or injury model specific. We demonstrated that the number of V2a interneurons contacted by collateral corticospinal sprouting fibres is positively correlated with skilled motor recovery. To address the mechanism behind the neuroplasticity-promoting effect of DHA, we investigated the expression of miR-21 and phosphatase and tensin homolog (PTEN) in cortical neurons and raphe nuclei after DHA treatment. We found that DHA significantly up-regulates miR-21 and down-regulates PTEN in corticospinal neurons one day after SCI. Downregulation of PTEN by DHA was also seen in dorsal root ganglion (DRG) neuron 3 cultures and was accompanied by increased neurite outgrowth. Lastly, we investigated whether DHA treatment combined with specific-task rehabilitation maximized the recovery of skilled forelimb function following cervical SCI. The rats receiving combined therapy achieved greater skilled forelimb functional recovery compared to DHA treatment or rehabilitation only. In summary, this study shows that DHA has therapeutic potential in cervical SCI and provides evidence that DHA could exert its beneficial effects in SCI via enhancement of neuroplasticity.

Subjects/Keywords: Medicine; cervical spine injury; spinal cord injury; Docosahexaenoic acid

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APA (6^th Edition):

Liu, Z. (2015). Mechanisms and novel therapies in cervical spinal cord injury. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/12862 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775157

Chicago Manual of Style (16^th Edition):

Liu, Zhuo-Hao. “Mechanisms and novel therapies in cervical spinal cord injury.” 2015. Doctoral Dissertation, Queen Mary, University of London. Accessed February 28, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/12862 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775157.

MLA Handbook (7^th Edition):

Liu, Zhuo-Hao. “Mechanisms and novel therapies in cervical spinal cord injury.” 2015. Web. 28 Feb 2021.

Vancouver:

Liu Z. Mechanisms and novel therapies in cervical spinal cord injury. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2015. [cited 2021 Feb 28]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12862 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775157.

Council of Science Editors:

Liu Z. Mechanisms and novel therapies in cervical spinal cord injury. [Doctoral Dissertation]. Queen Mary, University of London; 2015. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/12862 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775157

University of Illinois – Urbana-Champaign

21. Jacob, Reeba M. Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain.

Degree: MS, Nutritional Sciences, 2015, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/78680

► Using the piglet as a model for the human infant, the goal of this study was to compare dietary lipid matrices found in infant formula… (more)

▼ Using the piglet as a model for the human infant, the goal of this study was to compare dietary lipid matrices found in infant formula and maternal milk on post-natal neurodevelopmental patterns. Over a 25-day feeding study, piglets (n=9-10 per treatment, 1.5 ± 0.2 kg initial BW) were either sow-reared (SR) with ad libitum intake, or artificially-reared (AR) receiving 1 of 3 milk replacers modified to mimic the nutritional profile and intake pattern of sow’s milk. Our AR treatments included: T1, artificially-reared (AR) control formula; T2, T1 + 45% total dietary fat replaced with pre-digested fat (PDF); T3, T2 + 10% lecithin + 0.4% cholesterol. Sow-reared animals were used as a positive control for study outcomes. Piglets were weighed daily, serum samples were collected at d 0, d 14, and d 25 of study, and fecal samples were collected, and pooled from d 13-27. At 3 weeks of age, piglets were subjected to a standardized set of magnetic resonance imaging (MRI) procedures to identify macro- and micro-structural characteristics of the brain. At study conclusion, piglets were euthanized and tissues were collected for further analysis. For the duration of the study, SR piglets exhibited higher BW gain and heavier extracted whole brain weights compared with AR piglets. Analysis of fecal fat suggested greater (P < 0.05) excretion of dietary fat with addition of PDF along with lecithin and cholesterol. Serum lipid profiling at d 14 and d 25 of study revealed serum triglycerides (TAG) concentrations to be higher (P = 0.176, P = 0.164) in T3-fed piglets when compared with T1- and T2-fed piglets. Furthermore, serum cholesterol concentrations were higher (P < 0.05) in T3-fed piglets when compared with T1- and T2-fed piglets on d 25 of study. Furthermore, hippocampal tissue analysis revealed neutral lipid (NL) docosahexaenoic acid (DHA) concentrations were greater (P < 0.05) in T3-fed pigs compared with T1-fed and SR pigs. Hippocampal phospholipid (PL) DHA concentrations of T2- or T3-fed pigs were intermediate to T1-fed and SR piglets. Diffusion tensor imaging, a MRI sequence that characterizes brain microstructure, revealed that SR piglets had greater (P < 0.05) average whole-brain fractional anisotropy (FA) values compared with AR piglets, suggesting differences in white matter organization. Although global analysis did not reveal differences within AR treatments for DTI outcomes, FA values of the internal capsule were not different between SR and T3-fed piglets, suggesting a modulatory effect of PDF + lecithin + cholesterol fat system on white matter maturation. Higher fecal fat excretion, partnered with higher serum TAG concentrations in T3-fed piglets as compared with other AR treatments, suggested higher bioavailability of the PDF when supplemented with lecithin and cholesterol. Elevated serum cholesterol at d 25 of study, partnered with elevated hippocampal DHA concentrations of T3-fed animals suggested higher bioavailability of the PDF, especially when supplemented with lecithin and cholesterol. Higher FA values in the…

Subjects/Keywords: Docosahexaenoic acid (DHA); Magnetic Resonance Imaging (MRI); Neurodevelopment

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APA (6^th Edition):

Jacob, R. M. (2015). Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/78680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jacob, Reeba M. “Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain.” 2015. Thesis, University of Illinois – Urbana-Champaign. Accessed February 28, 2021. http://hdl.handle.net/2142/78680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jacob, Reeba M. “Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain.” 2015. Web. 28 Feb 2021.

Vancouver:

Jacob RM. Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2142/78680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jacob RM. Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain. [Thesis]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/78680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

22. Finaldi, Anne-Marie. Studies on lipid mediators, and on potential modulators of GRP78.

Degree: PhD, Chemistry, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343800/rec/6176

► The research presented within this dissertation is a compilation of three projects with the underlying theme of designing and synthesizing relevant molecules for biological studies.… (more)

Subjects/Keywords: lipid mediators; docosahexaenoic acid; resolvins; protectins; inflammation; cancer; GRP78

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APA (6^th Edition):

Finaldi, A. (2014). Studies on lipid mediators, and on potential modulators of GRP78. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343800/rec/6176

Chicago Manual of Style (16^th Edition):

Finaldi, Anne-Marie. “Studies on lipid mediators, and on potential modulators of GRP78.” 2014. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343800/rec/6176.

MLA Handbook (7^th Edition):

Finaldi, Anne-Marie. “Studies on lipid mediators, and on potential modulators of GRP78.” 2014. Web. 28 Feb 2021.

Vancouver:

Finaldi A. Studies on lipid mediators, and on potential modulators of GRP78. [Internet] [Doctoral dissertation]. University of Southern California; 2014. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343800/rec/6176.

Council of Science Editors:

Finaldi A. Studies on lipid mediators, and on potential modulators of GRP78. [Doctoral Dissertation]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/343800/rec/6176

Clemson University

23. Klein, Catherine. Biohydrogenation of Docosahexaenoic Acid.

Degree: PhD, Animal and Veterinary Sciences, 2011, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/802

► Pathways of docosahexaenoic (DHA) biohydrogenation are not known; however, DHA is metabolized by ruminal microorganisms. The addition of DHA to the rumen alters the fatty… (more)

▼ Pathways of docosahexaenoic (DHA) biohydrogenation are not known; however, DHA is metabolized by ruminal microorganisms. The addition of DHA to the rumen alters the fatty acid profile of the rumen and milk and leads to increased trans-18:1 isomers, particularly trans-11 18:1 and 22 carbon fatty acids. This study included four in vitro experiments to identify if these are produced from DHA or if they come from other sources that are affected by DHA. In each experiment, ruminal microorganisms collected from a lactating Holstein cow were incubated in batch cultures for 0, 6, 24, and 48h and a uniformly 13C DHA was added to the cultures at 0 h as a metabolic tracer. In all experiments, any fatty acid that was enriched with the 13C label was determined to arise from DHA. In chapter 1, palmitic (C16:0), stearic (C18:0), all trans-18:1, eicosanoic (C20:0), and docosanoic (C22:0) acids were examined for enrichment. Chapter 1 included 2 experiments utilizing 10ml batch cultures that examined 0, 0.5, 1, 2, and 3% DHA supplementation to determine if DHA is converted into trans-18:1 and if the level of DHA effected its conversion into trans-11 18:1. Trans-18:1 isomers increased 254, 185, 256, and 272% from 0 to 48 h when DHA was supplemented at 0.5, 1, 2, and 3%, respectively; however, there was no label in trans-18:1 at any time. Docosanoic acid was highly enriched at 24 h and 48 h to 20.2% and 16.3%. Low levels of enrichment were found in palmitic and stearic acids. Enrichment of docosanoic acid decreased linearly with increased DHA supplementation. Chapter 2 studies utilized 25ml batch cultures with 0, 0.5, and 1% DHA to examine unsaturated 22 carbon fatty acids. In 0.5% DHA cultures, up to 2 isomers of C22:5, 4 isomers of C22:4, 5 isomers of C22:3, and 5 isomers of C22:1 were isolated in 6, 24, or 48h cultures. In 1% DHA cultures, up to 5 isomers of C22:5, 6 isomers of C22:4, 5 isomers of C22:3, and 3 isomers of C22:1 were isolated in 6, 24, or 48h cultures. No isomers of unsaturated 22 carbon fatty acids were isolated from cultures when DHA was not added. Over time, the isotope profiles changed from 55% C22:5 at 6h to 35% C22:3 and 29% 22:1 at 48h. All of the 22 carbon unsaturated fatty acids contained the 13C label indicating that they are produced from DHA. These experiments indicate that DHA is not converted into C18:1 fatty acids but is hydrogenated to 22 carbon fatty acids. Advisors/Committee Members: Jenkins, Thomas C, Bridges , William C, Duckett , Susan K, Powell , Gary L.

Subjects/Keywords: Biohydrogenation; DHA; Docosahexaenoic acid; Rumen; Trans fatty acids; Animal Sciences

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APA (6^th Edition):

Klein, C. (2011). Biohydrogenation of Docosahexaenoic Acid. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/802

Chicago Manual of Style (16^th Edition):

Klein, Catherine. “Biohydrogenation of Docosahexaenoic Acid.” 2011. Doctoral Dissertation, Clemson University. Accessed February 28, 2021. https://tigerprints.clemson.edu/all_dissertations/802.

MLA Handbook (7^th Edition):

Klein, Catherine. “Biohydrogenation of Docosahexaenoic Acid.” 2011. Web. 28 Feb 2021.

Vancouver:

Klein C. Biohydrogenation of Docosahexaenoic Acid. [Internet] [Doctoral dissertation]. Clemson University; 2011. [cited 2021 Feb 28]. Available from: https://tigerprints.clemson.edu/all_dissertations/802.

Council of Science Editors:

Klein C. Biohydrogenation of Docosahexaenoic Acid. [Doctoral Dissertation]. Clemson University; 2011. Available from: https://tigerprints.clemson.edu/all_dissertations/802

California State University – Northridge

24. Levy, Mor. THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN.

Degree: MS, Department of Family and Consumer Sciences, 2015, California State University – Northridge

URL: http://hdl.handle.net/10211.3/145011

► The prevalence of omega-3 fatty acid deficiency is a growing public health concern. In an effort to address this problem, a curriculum to increase knowledge… (more)

Subjects/Keywords: Docosahexaenoic acid; Dissertations, Academic – CSUN – Family & Consumer Sciences.

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APA (6^th Edition):

Levy, M. (2015). THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/145011

Chicago Manual of Style (16^th Edition):

Levy, Mor. “THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN.” 2015. Masters Thesis, California State University – Northridge. Accessed February 28, 2021. http://hdl.handle.net/10211.3/145011.

MLA Handbook (7^th Edition):

Levy, Mor. “THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN.” 2015. Web. 28 Feb 2021.

Vancouver:

Levy M. THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN. [Internet] [Masters thesis]. California State University – Northridge; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10211.3/145011.

Council of Science Editors:

Levy M. THE IMPORTANCE OF CONSUMING OMEGA 3 FATTY ACIDS: THE DEVELOPMENT OF A NUTRITION AND EDUCATION CURRICULUM FOR PREGNANT AND BREASTFEEDING WOMEN. [Masters Thesis]. California State University – Northridge; 2015. Available from: http://hdl.handle.net/10211.3/145011

University of Kansas

25. Littrell, Juleah. Docosahexaenoic Acid and Childhood Blood Pressure.

Degree: MS, Dietetics & Nutrition, 2018, University of Kansas

URL: http://hdl.handle.net/1808/27084

► Background: Long chain polyunsaturated fatty acids (LCPUFAs) have been shown to reduce blood pressure (BP) while they are being consumed; however, there is also evidence… (more)

Subjects/Keywords: Nutrition; blood pressure; childhood; DHA; docosahexaenoic acid; pregnancy

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APA (6^th Edition):

Littrell, J. (2018). Docosahexaenoic Acid and Childhood Blood Pressure. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/27084

Chicago Manual of Style (16^th Edition):

Littrell, Juleah. “Docosahexaenoic Acid and Childhood Blood Pressure.” 2018. Masters Thesis, University of Kansas. Accessed February 28, 2021. http://hdl.handle.net/1808/27084.

MLA Handbook (7^th Edition):

Littrell, Juleah. “Docosahexaenoic Acid and Childhood Blood Pressure.” 2018. Web. 28 Feb 2021.

Vancouver:

Littrell J. Docosahexaenoic Acid and Childhood Blood Pressure. [Internet] [Masters thesis]. University of Kansas; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1808/27084.

Council of Science Editors:

Littrell J. Docosahexaenoic Acid and Childhood Blood Pressure. [Masters Thesis]. University of Kansas; 2018. Available from: http://hdl.handle.net/1808/27084

Portland State University

26. Gu, Yongwen. The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence.

Degree: PhD, Physics, 2014, Portland State University

URL: https://pdxscholar.library.pdx.edu/open_access_etds/1950

► Plasma membranes are essential to both the structure and function of mammalian cells. The first unifying paradigm of membrane structure, the Fluid Mosaic Model,… (more)

▼ Plasma membranes are essential to both the structure and function of mammalian cells. The first unifying paradigm of membrane structure, the Fluid Mosaic Model, is no longer considered adequate to describe the many non-homogeneous lipid structures that have been observed in both natural and model membranes over the past approximately thirty years. The field of membrane biophysics now appreciates that the complex mixture of different lipid species found in natural membranes produces a range of dynamic, laterally segregated, non-homogeneous structures which exist on time scales ranging from microseconds to minutes. When sphingomyelin (SM), POPC and cholesterol are all present in a bilayer there is wide range of compositional ratios where the bilayer consists of a coexistence between two fluid phases designated liquid ordered (lo) and liquid disordered (ld). The lo phase is cholesterol-rich phase characterized by relatively high molecular order and slow rotational and translational motion, while the ld phase generally has low molecular order and relatively rapid rotational and translational motion. The driving force for the formation of these two phases is the ability of cholesterol to form favorable van der Waals contacts with the two saturated acyl chains on PSM and the one saturated acyl chain on POPC. The ternary system is an important model system for examining the physical properties and functional implications of co-existing lo and ld phases. However, it does not include one of the most significant compositional variables found in many important mammalian membranes. Membranes in the nervous system contain high concentrations of the highly polyunsaturated fatty acid docosahexaenoic acid (DHA), which contains 22 carbons and 6 double bonds. A wide range of experimental evidence shows that DHA-containing phospholipids are important for optimal performance of a number of membrane signaling systems and membrane protein functions. The goal of this study is to determine how addition of a DHA-containing phospholipid, PDPC alters the biologically important lo and ld co-existence region. Advisors/Committee Members: Drake C. Mitchell.

Subjects/Keywords: Docosahexaenoic acid; Lecithin; Lipid membranes; Unsaturated fatty acids; Fluorescence; Biophysics; Lipids

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APA (6^th Edition):

Gu, Y. (2014). The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence. (Doctoral Dissertation). Portland State University. Retrieved from https://pdxscholar.library.pdx.edu/open_access_etds/1950

Chicago Manual of Style (16^th Edition):

Gu, Yongwen. “The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence.” 2014. Doctoral Dissertation, Portland State University. Accessed February 28, 2021. https://pdxscholar.library.pdx.edu/open_access_etds/1950.

MLA Handbook (7^th Edition):

Gu, Yongwen. “The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence.” 2014. Web. 28 Feb 2021.

Vancouver:

Gu Y. The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence. [Internet] [Doctoral dissertation]. Portland State University; 2014. [cited 2021 Feb 28]. Available from: https://pdxscholar.library.pdx.edu/open_access_etds/1950.

Council of Science Editors:

Gu Y. The Effect of Docosahexaenoic Acid (DHA)-Containing Phosphatidylcholine (PC) on Liquid-Ordered and Liquid-Disordered Coexistence. [Doctoral Dissertation]. Portland State University; 2014. Available from: https://pdxscholar.library.pdx.edu/open_access_etds/1950

University of Cincinnati

27. Brook, Loren P. The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups.

Degree: MS, Allied Health Sciences: Nutrition, 2012, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342464199

► Objective: To examine the relationship between erythrocyte docosahexaenoic acid (DHA) and inflammatory biomarkers in the 35th-37th week of gestation in healthy overweight/obese pregnant women… (more)

▼ Objective: To examine the relationship between erythrocyte docosahexaenoic acid (DHA) and inflammatory biomarkers in the 35th-37th week of gestation in healthy overweight/obese pregnant women 18-40 years of age of different races/ethnicities (African American, Hispanic, White), following 10 weeks of supplementation with or 530 mg corn/soybean oil blend. Design: Randomized, double-blinded, placebo-controlled trial. Subjects: 107 healthy gravidas between the ages of 18-40 years with a singleton pregnancy, body mass index (BMI) >25, and who completed all study visits. Methods: Pregnant women were randomized into either the DHA or control group. Subjects were given either 800 mg purified algae docosahexaenoic or 530 mg corn/soybean oil blend beginning at the 26th week until the 35th-37th week of their pregnancy. Venous blood was collected during three study visits and analyzed for erythrocyte DHA, adiponectin, IL-6 and TNF-alpha. Outcome variables were assessed as the differences in the absolute measurement (values) and percent change (%) between baseline and study end measurements. Mean values are reported for normally distributed data and median values with interquartile ratios were reported for skewed data. One-way ANOVA was used to compare means by study group. The Kruska-Wallis Test was used as a non-parametric alternative to a one-way ANOVA. Two-way ANOVA was used to identify effects between inflammatory biomarkers (TNF-alpha, IL-6, adiponectin), and ethnicity between study groups. Results: Women supplemented with DHA had significantly higher erythrocyte DHA as compared to the control group. There was a significant interaction between the study group and ethnic background on change in erythrocyte DHA, and blood levels of TNF-alpha (p<0.03, p<0.05 respectively). Hispanic and White women had an increase and African-American women a decrease in erythrocyte DHA following supplementation. In the control group, the African-American and White women had a slight increase in TNF-alpha (0.92 pg/ml, 1.2 pg/ml, respectively) and the Hispanic women had a slight decrease (-0.36). In the DHA group, all women had less than a 0.25 pg/ml increase in TNF-alpha. When experimental groups were divided based on race/ethnicity, the median level of absolute change in blood levels of adiponectin, IL-6, and TNF-alpha were different between the three groups (p<0.05, p<0.01, p<0.001 respectively). Conclusion: DHA supplementation has varying effects on inflammatory biomarkers in healthy overweight/obese pregnant women of different races/ethnicities. Ethnicity and DHA supplementation have interacting effects on both erythrocyte DHA and blood TNF-alpha levels. Modifying DHA supplementation based on race/ethnicity may lower inflammatory status in pregnancy and improve negative fetal outcomes. Advisors/Committee Members: Krummel, Debra Ann (Committee Chair).

Subjects/Keywords: Nutrition; Pregnancy; docosahexaenoic acid; obesity; inflammation; TNF-alpha

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brook, L. P. (2012). The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342464199

Chicago Manual of Style (16^th Edition):

Brook, Loren P. “The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups.” 2012. Masters Thesis, University of Cincinnati. Accessed February 28, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342464199.

MLA Handbook (7^th Edition):

Brook, Loren P. “The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups.” 2012. Web. 28 Feb 2021.

Vancouver:

Brook LP. The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups. [Internet] [Masters thesis]. University of Cincinnati; 2012. [cited 2021 Feb 28]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342464199.

Council of Science Editors:

Brook LP. The effect of DHA supplementation on inflammatory biomarkers in overweight/obese pregnant women of different ethnic groups. [Masters Thesis]. University of Cincinnati; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342464199

Cornell University

28. Klatt, Kevin C. Phosphatidylcholines: Beyond the Membrane.

Degree: PhD, Nutrition, 2018, Cornell University

URL: http://hdl.handle.net/1813/59560

► Phosphatidylcholines (PC) are the most abundant phospholipids in mammalian cells, where they serve well-characterized structural roles, maintaining membrane integrity, facilitating lipoprotein assembly and serving as… (more)

▼ Phosphatidylcholines (PC) are the most abundant phospholipids in mammalian cells, where they serve well-characterized structural roles, maintaining membrane integrity, facilitating lipoprotein assembly and serving as a surfactant in the lung. Over the past decade, seminal papers have been published that describe novel roles for specific PC species derived from both the cytidine diphosphate-choline (CDP-choline) and phosphatidylethanolamine N-methyltransferase (PEMT) pathways of PC synthesis; these roles include both nuclear receptor agonism and generating critical physiological pools of the omega 3 fatty acid, docosahexaenoic acid (DHA). In addition to these novel functions, complex interactions between PC and its substrate, choline, with growth and energetic status have emerged, following the observation that the mammalian target of rapamycin complex 1 (mTORC1) is a major regulator of PC synthesis through the CDP-choline pathway. Presented in this dissertation are the tests of our primary hypotheses informed directly from these emerging areas of phosphatidylcholine biology. Chapter 2 of this dissertation examines the impact of diet on the production of dilauroylphosphatidylcholine (DLPC), a phosphatidylcholine species enriched in lauric acid that was recently identified as a ligand for the nuclear receptor, liver receptor homolog-1 (LRH-1). DLPC binding to LRH-1 results in modulation of LRH-1-dependent hepatic gene expression and improvements in glucose and lipid handling. While DLPC has been convincingly shown to bind and activate LRH-1 when provided exogenously to cultured cells and mice, endogenous production of DLPC has not been observed, questioning its significance in the regulation of mammalian physiology. We hypothesized that the absence of DLPC in mammalian tissues results from substrate insufficiency (i.e. low lauric acid supply) and that provision of lauric acid, either in the culture media or the mammalian diet, will result in endogenous DLPC production, and be associated with functional LRH-1 activation. Cell culture models, animal feeding experiments, and a single-blind, randomized, controlled crossover acute feeding study in human participants were used to test this hypothesis. As hypothesized, provision of lauric acid in the cell culture media, animal diet, and human diet resulted in the acute and chronic production of DLPC. In cultured cells, this was associated with upregulation of LRH-1 dependent transcripts, an effect that was blunted by co-treatment with a LRH-1 antagonist. In animals, feeding of high fat diets containing lauric acid, utilizing purified lauric acid or coconut oil-based diets, resulted in substantial improvements in glucose handling as indicated by an oral glucose tolerance test. Chapter 3 of this dissertation examines the association of dietary choline intake and reproductive stage with plasma lysophosphatidylcholine (LPC)-DHA among women participants of a 10 week controlled feeding study. LPC-DHA has been recently highlighted as a physiological pool of DHA for maintaining… Advisors/Committee Members: Caudill, Marie A. (chair), Roberson, Mark Stephen (committee member), Brenna, James Thomas (committee member), Thalacker-Mercer, Anna E. (committee member).

Subjects/Keywords: lauric acid; lysophosphatidylcholine; phosphatidylcholine; Nutrition; Molecular biology; Medicine; coconut oil; dilauroylphosphatidylcholine; docosahexaenoic acid

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APA (6^th Edition):

Klatt, K. C. (2018). Phosphatidylcholines: Beyond the Membrane. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/59560

Chicago Manual of Style (16^th Edition):

Klatt, Kevin C. “Phosphatidylcholines: Beyond the Membrane.” 2018. Doctoral Dissertation, Cornell University. Accessed February 28, 2021. http://hdl.handle.net/1813/59560.

MLA Handbook (7^th Edition):

Klatt, Kevin C. “Phosphatidylcholines: Beyond the Membrane.” 2018. Web. 28 Feb 2021.

Vancouver:

Klatt KC. Phosphatidylcholines: Beyond the Membrane. [Internet] [Doctoral dissertation]. Cornell University; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1813/59560.

Council of Science Editors:

Klatt KC. Phosphatidylcholines: Beyond the Membrane. [Doctoral Dissertation]. Cornell University; 2018. Available from: http://hdl.handle.net/1813/59560

Mahatma Gandhi University

29. Joseph, Sophia Margaret. Biological effects of feeding cuttle fish liver oil to rats; -.

Degree: Biochemistry, 2013, Mahatma Gandhi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/7113

►

The cuttlefish liver discarded during processing contains a high oil content (6- 40%) and is a rich source of and#969;-3 polyunsaturated fatty acids (and#969;-3 PUFAs)… (more)

Subjects/Keywords: immune function; cuttlefish liver oil; atherogenesis; eicosapentaenoic acid; docosahexaenoic acid; cardioprotective; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joseph, S. M. (2013). Biological effects of feeding cuttle fish liver oil to rats; -. (Thesis). Mahatma Gandhi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/7113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Joseph, Sophia Margaret. “Biological effects of feeding cuttle fish liver oil to rats; -.” 2013. Thesis, Mahatma Gandhi University. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/7113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Joseph, Sophia Margaret. “Biological effects of feeding cuttle fish liver oil to rats; -.” 2013. Web. 28 Feb 2021.

Vancouver:

Joseph SM. Biological effects of feeding cuttle fish liver oil to rats; -. [Internet] [Thesis]. Mahatma Gandhi University; 2013. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/7113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Joseph SM. Biological effects of feeding cuttle fish liver oil to rats; -. [Thesis]. Mahatma Gandhi University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/7113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waterloo

30. Lamontagne-Kam, Daniel. The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence.

Degree: 2019, University of Waterloo

URL: http://hdl.handle.net/10012/14546

► Sex differences in plasma docosahexaenoic acid (DHA) status during adulthood have been documented previously, and recent studies suggest the effects of DHA supplementation on human… (more)

▼ Sex differences in plasma docosahexaenoic acid (DHA) status during adulthood have been documented previously, and recent studies suggest the effects of DHA supplementation on human cognition are different in females compared with males during infancy, adolescence, and early adulthood. Differences in estradiol concentration are believed to be the predominant factor in sexual dimorphisms in DHA status when DHA is not supplemented. This suggests that sexual dimorphisms begin during adolescence when fed diets not supplemented with DHA, but this has not been examined comprehensively. Therefore, this thesis examined: 1) DHA status in rat maternal, fetal and pup tissues with and without dietary DHA supplementation during pregnancy; 2) the onset of sex differences in the fatty acid composition of plasma, heart, brain and liver from birth to adulthood in rats fed chow diets; and 3) the impact of DHA supplementation during the perinatal period on spatial memory in female and male adolescent pups, and possible relationships to brain lipidomic profiles. Results from these studies show that maternal DHA status decreased significantly during the postpartum period when DHA was not provided in the diet and suggest that DHA could be mobilized from maternal adipose and possibly maternal heart and liver for milk production. Furthermore, results show that sex differences in tissue polyunsaturated fatty acids (PUFA) began at 6 weeks of age. In the spatial memory experiment, DHA supplementation significantly increased latency times during the final learning session of Morris Water Maze (MWM) testing and reduced arachidonic acid (ARA) and n-6 docosapentaenoic acid (DPA) containing phospholipid species in the hippocampus of both males and females. Understanding the effects of DHA supplementation during the perinatal and adolescent periods on the PUFA composition of maternal and pup tissues, and how these effects interact with sexual dimorphisms is critical to understanding dietary requirements of DHA throughout pregnancy and childhood. Additionally, MWM testing and lipidomic analyses indicate that DHA supplementation may interact with long chain n-6 PUFA metabolism that may be important for spatial memory.

Subjects/Keywords: docosahexaenoic acid; lipidomics; omega-3; fatty acid; spatial memory; pregnancy; lipids; sex differences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lamontagne-Kam, D. (2019). The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/14546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lamontagne-Kam, Daniel. “The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence.” 2019. Thesis, University of Waterloo. Accessed February 28, 2021. http://hdl.handle.net/10012/14546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lamontagne-Kam, Daniel. “The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence.” 2019. Web. 28 Feb 2021.

Vancouver:

Lamontagne-Kam D. The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence. [Internet] [Thesis]. University of Waterloo; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10012/14546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lamontagne-Kam D. The Effects of Dietary DHA During Development on Maternal Tissue and Spatial Memory in Female and Male Pups During Adolescence. [Thesis]. University of Waterloo; 2019. Available from: http://hdl.handle.net/10012/14546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations