subject:(Diseases)

University of Zambia

1. Kampamba, Kelvin Mulenga. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

► Tungiasis, also commonly known as jiggers, is a zoonotic ectoparasitosis caused by the permanent penetration of the epidermis by a gravid female sand flea Tunga… (more)

▼ Tungiasis, also commonly known as jiggers, is a zoonotic ectoparasitosis caused by the permanent penetration of the epidermis by a gravid female sand flea Tunga penetrans in the skin of a host. The skin disease is known to occur throughout Latin America, the Caribbean and sub Saharan Africa especially among resource poor communities. There is no or little epidemiologic data on the skin disease in Zambia. A cross-section study was conducted in rural communities in Chipata and Vubwi districts of Zambia to determine the prevalence, risk factors and levels of awareness of tungiasis. A total of 384 households were visited from where at least one member was interviewed and examined. A household was considered infested if at least one individual had tungiasis. Collected data included among others social demographic characteristics, household living conditions, localization of the lesions, nature of lesions (avital or vital), number of embedded female T. penetrans and tungiasis specific disease related information including knowledge. The overall prevalence of active tungiasis in the study area was 13.5% (95% CI= 10.1 – 16.9) with Chipata recording 12.6% (95% CI= 8.5 – 16.7) and Vubwi 15.3% (95% CI= 9.3 – 21.3). On assessment of risk factors, individuals in age categories ≤ 15years and those ≥ 60 years showed higher prevalence 68.8% (95% CI= 46.1 – 91.5) and 18.2% (95% CI=2.1 – 34.3), respectively, compared to those in the intermediary age groups (p=0.001). The type of sanitary facilities and marital status as it related to age were found to be significant predictors of tungiasis (p<0.05). Living in a households with a pit latrines reduced the risk of tungiasis by 25.4% (95% CI= 0.071 – 0.913), when compared to those that practiced open defecation (p=0.036). Those that were of marriageable age and single (>20 years old and single) were 19.7 (95% CI= 5.152 – 75.469) more likely to have tungiasis than those that were married and ≥20 years old (p=0.001). All other variables were not significantly associated with T. penetrans (p>0.05). The levels of awareness of the disease in the study area were very good, ranging from 80% to 83% on the basis of having experienced tungiasis and 3.3% to 71% on disease specific knowledge. Tungiasis is prevalent among the studied rural communities in Chipata and Vubwi districts. Although the awareness of the disease was high in the studied communities, people were not able to link tungiasis with risk factors. More research work needs to be done in order to rank the risk factors and to determine the burden tungiasis exerts in economic terms.

Subjects/Keywords: Skin – Diseases; Foot – Diseases

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APA (6^th Edition):

Kampamba, K. M. (2015). Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kampamba, Kelvin Mulenga. “Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .” 2015. Thesis, University of Zambia. Accessed April 10, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kampamba, Kelvin Mulenga. “Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .” 2015. Web. 10 Apr 2021.

Vancouver:

Kampamba KM. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Apr 10]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kampamba KM. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Chavwanga, Vytalis. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.

Degree: 2014, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/3215

► The study examines the role of the Department of Veterinary Services in controlling and preventing contagious cattle diseases in Zambia from 1907 to 1990. The… (more)

Subjects/Keywords: Cattle Diseases; Domestic Animals-Diseases

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APA (6^th Edition):

Chavwanga, V. (2014). The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chavwanga, Vytalis. “The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.” 2014. Thesis, University of Zimbabwe. Accessed April 10, 2021. http://dspace.unza.zm/handle/123456789/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chavwanga, Vytalis. “The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.” 2014. Web. 10 Apr 2021.

Vancouver:

Chavwanga V. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2021 Apr 10]. Available from: http://dspace.unza.zm/handle/123456789/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chavwanga V. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

3. Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. Combined Disorders of Heart and Kidney : Heart and Kidney Link.

Degree: Department of Biology, 2016, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,2379

►

It is now clear that renal dysfunction is linked frequently with all types of heart failure (HF), and its development is associated with higher death… (more)

▼

It is now clear that renal dysfunction is linked frequently with all types of heart failure (HF), and its development is associated with higher death rates and morbidity. There is not any approved definition for the cardiorenal syndrome (CRS), but in general, CRS can be defined as a pathophysiologic disorder of both heart and kidneys in which acute or chronic dysfunction of one organ may cause acute or chronic dysfunction of the other. The aim of this thesis is to discuss the pathophysiology and clinical features of the link between heart disorders and kidney disorders in light of the actual clinical and experimental evidence. Because of the complex interdependent relationship, changes in heart and the kidney systems have been difficult to describe. Thus, CRS has been subdivided into five syndromes which include Type 1 CRS which is an acute cardiac event precipitating acute kidney injury (AKI); Type 2 CRS which is defined as a developing and permanent chronic kidney dysfunction which is induced by long-term cardiac dysfunction, for example, chronic congestive heart failure; Type 3 CRS which is described as an acute cardiac dysfunction and it is caused by a sudden renal dysfunction; Type 4 CRS which is defined as one in which chronic kidney diseases cause a worsening of cardiac function, cardiac hypertrophy, and/or progressive risk of adverse cardiovascular events; Type 5 CRS which is concomitant cardiac and renal dysfunctions due to systemic conditions that affect both organs, for example, diabetes mellitus and sepsis. In patients with severe sepsis, acute cardiovascular and renal dysfunction are common. Cardiorenal syndromes' pathophysiology includes endothelial dysfunction, alteration of myocardial function, reduced renal perfusion and venous congestion. Therefore, there should be preventive and diagnostic strategies that can preserve renal function and heart output in patients with kidney and/or HF.

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biological Sciences."; Thesis advisor: Ruth Rollin.; M.S.,Central Connecticut State University,,2016.;

Advisors/Committee Members: Rollin, Ruth.

Subjects/Keywords: Heart – Diseases.; Kidneys – Diseases.

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APA (6^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1. (2016). Combined Disorders of Heart and Kidney : Heart and Kidney Link. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. “Combined Disorders of Heart and Kidney : Heart and Kidney Link.” 2016. Thesis, Central Connecticut State University. Accessed April 10, 2021. http://content.library.ccsu.edu/u?/ccsutheses,2379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. “Combined Disorders of Heart and Kidney : Heart and Kidney Link.” 2016. Web. 10 Apr 2021.

Vancouver:

Alrifai, Walaa A. (Walaa Abdulalrhman) 1. Combined Disorders of Heart and Kidney : Heart and Kidney Link. [Internet] [Thesis]. Central Connecticut State University; 2016. [cited 2021 Apr 10]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alrifai, Walaa A. (Walaa Abdulalrhman) 1. Combined Disorders of Heart and Kidney : Heart and Kidney Link. [Thesis]. Central Connecticut State University; 2016. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

4. Narayanappa, Murugesh. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.

Degree: PhD, Biochemistry and Biophysics, 2016, Oregon State University

URL: http://hdl.handle.net/1957/60041

► Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after… (more)

▼ Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost society an average of 300,000 dollars over the lifetime of a person. It also has serious impacts on quality of life including the literacy rate in children. Although, hearing loss is clearly a major health problem its genetic basis for the pathology is poorly understood. To date, over 60 pathogenic mutations in otoferlin have been found to be associated with inherited, non-syndromic congenital hearing loss and temperature sensitive auditory neuropathy (TSAN). The sense of hearing depends on reliable and temporally precise neurotransmitter release at the synapses of inner hair cells (IHCs) of the cochlea. Inner hair cells of the cochlea derive their name from hair bundle (stereocilia) protruding at the apical tip of the cell, that are arranged in rows of graded height. The nanometer displacement of the hair bundle opens mechanically gated ion channels that depolarize the cell. This change in membrane potential triggers calcium dependent fusion of synaptic vesicles with the plasma membrane and the release of neurotransmitter. In IHCs, Calcium-regulated exocytosis and neurotransmitter release exhibit fast kinetics in achieving exquisite temporal fidelity. To aid in fidelity and for allowing high rates of sustained synaptic neurotransmission, IHCs contain specialized structures called synaptic ribbons for tethering synaptic vesicles at release sites. The calcium triggered synaptic vesicle fusion with the plasma membrane is believed to be driven by the assembly of SNARE proteins. However, SNARE proteins are insensitive to calcium. In conventional neurotransmission in neurons, synaptotagmin 1 confers calcium sensitivity to SNARE-mediated fast synchronous neurotransmission. However, Yasunaga et al. 1999 and Beurg et al. 2010 have reported that synaptotagmin 1 was not detected in mature IHCs and it has been suggested that IHCs have evolved a unique calcium sensor, otoferlin for calcium-regulated synaptic neurotransmission. The evidence for calcium sensor hypothesis of otoferlin comes from Roux et al., 2006 who reported that mice lacking otoferlin were profoundly deaf and lack synaptic vesicle exocytosis in IHCs. Otoferlin has also been shown to be required for calcium dependent synaptic exocytosis at immature outer hair cells (OHCs) and vestibular hair cells. Otoferlin belongs to ferlin family of proteins and consists of six C2 domains (C2A- C2F) linked in tandem followed by a single-pass C-terminal transmembrane region. C2 domains are known to bind to calcium and lipids. The lipid and calcium binding properties of synaptic proteins are critical characteristics that define and shape the release properties of a synapse, and thus, without a quantitative characterization of these activities, an understanding of… Advisors/Committee Members: Johnson, Colin (advisor), Weihong, Qiu (committee member).

Subjects/Keywords: Cochlea – Diseases

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APA (6^th Edition):

Narayanappa, M. (2016). Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/60041

Chicago Manual of Style (16^th Edition):

Narayanappa, Murugesh. “Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.” 2016. Doctoral Dissertation, Oregon State University. Accessed April 10, 2021. http://hdl.handle.net/1957/60041.

MLA Handbook (7^th Edition):

Narayanappa, Murugesh. “Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.” 2016. Web. 10 Apr 2021.

Vancouver:

Narayanappa M. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. [Internet] [Doctoral dissertation]. Oregon State University; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1957/60041.

Council of Science Editors:

Narayanappa M. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. [Doctoral Dissertation]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/60041

University of Tasmania

5. Au, BT. Reliability and validity of physical activity measurements in Vietnam.

Degree: 2010, University of Tasmania

URL: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

► Mortality from non-communicable diseases (NCD) has increased in Vietnam in recent decades. Relatively little is known about the prevalence of risk factors for NCD in… (more)

▼ Mortality from non-communicable diseases (NCD) has increased in Vietnam in recent decades. Relatively little is known about the prevalence of risk factors for NCD in Vietnam, particularly for rural populations living outside the two major cities of Ha Noi and Ho Chi Minh City. The measurement of physical inactivity, an established risk factor for disease in Western populations, has not been attempted. The principal aim of this thesis was to test the reliability and validity of several methods of measuring physical activity in the Vietnamese population. A secondary aim was to investigate the prevalence of physical inactivity and other NCD risk factors in a population-based sample of rural Vietnam. A population survey (n=1978) was conducted in 2005 in Can Tho in the Mekong Delta of southern Vietnam, using the STEPS methodology developed by the World Health Organisation. Measurements of physical activity were made using the Global Physical Activity Questionnaire (GPAQ). GPAQ is a modified version of the International Physical Activity Questionnaire (IPAQ). A sub-sample (n=251) of participants had multiple measurements of physical activity using GPAQ, IPAQ, pedometers, and physical activity records (PAR). The key findings were: 1. The prevalence of NCD risk factors in the dominantly rural sample were very different from those previously reported for big city samples from Ha Noi and Ho Chi Minh City. 2. Work activity constituted 80% of total moderate and vigorous activity, and 33% of men and 40% of women were classified as inactive. 3. The modifications of IPAQ in the design of GPAQ have improved the physical activity estimates for those with stable work patterns, but, overall, both questionnaires had modest reliability and validity in estimating physical activity. 4. It was feasible to obtain a superior estimate of physical activity using at least three days of pedometer wear. 5. The use of pedometers was culturally acceptable to the local population. The involvement of health volunteers was critical, but they require constant supervision. 6. Tobacco smoking, a potential confounder of the association between physical activity and NCD risk indicators, was associated with hypertension in a doseresponse fashion. 7. Physical activity measured by GPAQ was associated with total cholesterol and, for men, with body composition and blood glucose. Work activity was the main contributor to these associations. For Vietnam, the GPAQ modifications of IPAQ have been only partly successful. Objective measurement by pedometers is feasible and culturally acceptable, and should be encouraged.

Subjects/Keywords: Exercise; Diseases

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APA (6^th Edition):

Au, B. (2010). Reliability and validity of physical activity measurements in Vietnam. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Au, BT. “Reliability and validity of physical activity measurements in Vietnam.” 2010. Thesis, University of Tasmania. Accessed April 10, 2021. https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Au, BT. “Reliability and validity of physical activity measurements in Vietnam.” 2010. Web. 10 Apr 2021.

Vancouver:

Au B. Reliability and validity of physical activity measurements in Vietnam. [Internet] [Thesis]. University of Tasmania; 2010. [cited 2021 Apr 10]. Available from: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Au B. Reliability and validity of physical activity measurements in Vietnam. [Thesis]. University of Tasmania; 2010. Available from: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

6. Hairgrove, Thomas Bearl. Emerging and Reemerging Diseases of Texas Beef Cattle.

Degree: PhD, Animal Science, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/187368

► This dissertation focused on three emerging/reemerging diseases posing economic impacts on Texas livestock producers. Bovine trichomoniasis is a regulated disease requiring diagnostic testing; however, current… (more)

▼ This dissertation focused on three emerging/reemerging diseases posing economic impacts on Texas livestock producers. Bovine trichomoniasis is a regulated disease requiring diagnostic testing; however, current diagnostic protocols are problematic. Major obstacles resulting from variable collection procedures and discrepancies in sample handling and laboratory test accuracy need further investigation. Epizootic hemorrhagic disease primarily affects white-tailed deer; however, it is unclear why clinical disease is rarely exhibited in cattle in the same region, requiring the investigation of seroprevalence in Texas cattle. Bovine viral diarrhea (BVD) causes significant reproductive loss and complicates other diseases through immunosuppression. Although vaccination is the primary method of mitigating fetal infection, a systematic review assessing fetal protection from vaccination is needed. Methods to examine the collection, shipment, and diagnostics associated with bovine trichomoniasis included (1) testing of infected bulls for sample quality and testing accuracy related to time, collectors, and individual bulls; (2) evaluation of samples with temperature sensors in a controlled environment when shipped by common carrier; and (3) evaluation of a patented polymerase chain reaction (PCR) technique for expedient sample handling and improved diagnostic sensitivity. Methods to evaluate prevalence of epizootic hemorrhagic disease in Texas cattle were based on random blood sera collections from 11 auction markets. Methods to assess safety and efficacy of BVD vaccines for fetal protection were based on a systematic review of the scientific literature. There was little variation in bovine trichomoniasis test results due to collector or bull, indicating proper and standardized sample collection protocol increased test accuracy. Shipping samples in temperature-controlled containers to arrive at the laboratory within 24 hours also improved diagnostic accuracy. The newly patented PCR test exhibited 100% diagnostic sensitivity and 99% specificity for field samples from 56 positive and 110 negative bulls for improved test accuracy. A high seroprevalence of epizootic hemorrhagic disease (70% to 97% depending on different threshold titer positive cutoff values) was seen in Texas auction cattle, but clinical disease is rare. Much of the scientific literature dealing with BVD supports vaccination for fetal protection but lacks transparency regarding experimental design, creating a potential for bias and making evaluation of these studies difficult. Advisors/Committee Members: Friend, Ted (advisor), Herring, Andy (committee member), Sawyer, Jason (committee member), Fajt, Virginia (committee member).

Subjects/Keywords: Emerging Diseases

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APA (6^th Edition):

Hairgrove, T. B. (2016). Emerging and Reemerging Diseases of Texas Beef Cattle. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187368

Chicago Manual of Style (16^th Edition):

Hairgrove, Thomas Bearl. “Emerging and Reemerging Diseases of Texas Beef Cattle.” 2016. Doctoral Dissertation, Texas A&M University. Accessed April 10, 2021. http://hdl.handle.net/1969.1/187368.

MLA Handbook (7^th Edition):

Hairgrove, Thomas Bearl. “Emerging and Reemerging Diseases of Texas Beef Cattle.” 2016. Web. 10 Apr 2021.

Vancouver:

Hairgrove TB. Emerging and Reemerging Diseases of Texas Beef Cattle. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1969.1/187368.

Council of Science Editors:

Hairgrove TB. Emerging and Reemerging Diseases of Texas Beef Cattle. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/187368

University of KwaZulu-Natal

7. Sahadew, Nikita. An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal.

Degree: 2015, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/13729

► The prevalence of diabetes is increasing globally, especially in African countries, where 62% of cases are undiagnosed and are seen by a medical professional only… (more)

▼ The prevalence of diabetes is increasing globally, especially in African countries, where 62% of cases are undiagnosed and are seen by a medical professional only once complications have manifested. Among the tangle of complications, the diabetic foot is a cause of morbidity and mortality. The management of foot ulcerations, non-ulcerative pathologies and the prevention of subsequent amputation is a challenge, resulting in physiological, psychological and economic consequences. Including a podiatrist in the multidisciplinary healthcare team involved in the care of the lower limbs of the diabetic patient has the potential to improve patient outcomes and reduce the economic burden incurred by both the patient and the state. The global increase in the prevalence of diabetes is most marked in African countries. The District Health Information System (DHIS) is the primary data collection system of the Department of Health in KwaZulu- Natal (KZN). Data is routinely collected at all public healthcare facilities in the province and is aggregated per facility. This study aimed to investigate the distribution of diabetic patients and podiatrists in the public health sector of the eleven KZN districts. A retrospective audit was conducted of the KZN Department of Health databases on diabetes in and between the years 2010 and 2014. The data was cleaned, tested for capture errors, verified and analysed. Using pivot tables, derived metrics, and graphs using Microsoft Excel were constructed. Additional open source databases were accessed to allow further exploration of the data collected. The prevalence of diabetes in the public health sector of KwaZulu-Natal was found to be 14.3% higher than national prevalence estimates. Thirty-eight per cent of the cases were found in the highly urbanised district of eThekwini. A total of 1 329 275 diabetic patients were recorded and, according to national guidelines for the treatment of diabetes, required podiatric care. However, only two podiatrists work in the KwaZulu-Natal public health sector. The number of podiatrists is totally insufficient to serve the growing diabetic population in this province’s public health sector. A major infusion of more podiatry graduates, appropriate distribution and inclusion of podiatric services into the diabetic foot care team needs to therefore be considered to enable compliance with national and international diabetic foot care guidelines. In the interim, existing public health care practitioners can be educated to offer diabetic foot care information to the patient and on the correct referral patterns to allow the patient access to a podiatrist. The findings of this study are consistent with the well-established relationship between diabetes and urbanisation. Correlation calculations support the assumption of a directly proportional relationship between diabetes prevalence and the number of diabetes-related amputations. This study highlights the need for at least 319 podiatrists in the province of KwaZulu-Natal to satisfy the national guidelines for… Advisors/Committee Members: Singaram, Veena S. (advisor), Brown, Susan Lynn. (advisor).

Subjects/Keywords: Infectious diseases.

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APA (6^th Edition):

Sahadew, N. (2015). An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/13729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sahadew, Nikita. “An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal.” 2015. Thesis, University of KwaZulu-Natal. Accessed April 10, 2021. http://hdl.handle.net/10413/13729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sahadew, Nikita. “An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal.” 2015. Web. 10 Apr 2021.

Vancouver:

Sahadew N. An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal. [Internet] [Thesis]. University of KwaZulu-Natal; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10413/13729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sahadew N. An explorative review of the distribution, incidence, prevalence, diabetes related amputations and defaulters of patients with diabetes mellitus and podiatrists in the public health care sector of KwaZulu-Natal. [Thesis]. University of KwaZulu-Natal; 2015. Available from: http://hdl.handle.net/10413/13729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

8. Ramtahal, Melissa Afton. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.

Degree: M.Med., Infectious diseases, 2011, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/6294

► Mycobacterium tuberculosis (MTB) is an airborne pathogen that is easily transmitted from person to person. An intact immune system prevents the organism from causing disease… (more)

Subjects/Keywords: Infectious diseases.

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APA (6^th Edition):

Ramtahal, M. A. (2011). Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. (Masters Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/6294

Chicago Manual of Style (16^th Edition):

Ramtahal, Melissa Afton. “Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.” 2011. Masters Thesis, University of KwaZulu-Natal. Accessed April 10, 2021. http://hdl.handle.net/10413/6294.

MLA Handbook (7^th Edition):

Ramtahal, Melissa Afton. “Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.” 2011. Web. 10 Apr 2021.

Vancouver:

Ramtahal MA. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. [Internet] [Masters thesis]. University of KwaZulu-Natal; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10413/6294.

Council of Science Editors:

Ramtahal MA. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. [Masters Thesis]. University of KwaZulu-Natal; 2011. Available from: http://hdl.handle.net/10413/6294

Nelson Mandela Metropolitan University

9. Du Plessis, Allison Herlene. A best practice guideline for screening and managing chorioamnionitis.

Degree: 2020, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/46374

► Due to the complex nature of chorioamnionitis, women are often misdiagnosed, undiagnosed or only diagnosed after birth when it is too late to prevent maternal… (more)

▼ Due to the complex nature of chorioamnionitis, women are often misdiagnosed, undiagnosed or only diagnosed after birth when it is too late to prevent maternal and neonatal complications. A lack of a comprehensive best practice guidelinefor screening and managing women withchorioamnionitis resultsin delayed treatment and management that could minimise maternal and neonatal complications. Saving Babiesreported that unexplained intra-uterine deathsremained the main primary (obstetric) cause of death for babies with a weight above 1000g (24.4%of all deaths). Of these unexplained uterine deaths, 33% are of normal birth weight (>2500g), and,therefore,most likely term gestation. Saving Babies further reported that 22.9% of all live births in South Africa was premature and 22.8% of birthswere unexplained intra-uterine deaths. Prematurity is one major complication of chorioamnionitis. When susceptibility for chorioamnionitis is considered during early pregnancy, it is possible to intervene and prevent or even reduce the incidences and complications of chorioamnionitis.A qualitative research study was conducted in three phases. In Phase One(Part One), a theoretically constructed patient scenario of chorioamnionitis was presented to ten midwives,and semi-structured individual interviews were done to elicit information regarding how they screen for and manage chorioamnionitis. In Phase One(Part Two), experienced medical practitioners in the field of obstetrics and gynaecology were individually interviewed, also using semi-structured individual interviewsto gain their views regarding chorioamnionitis as a contributing factor to maternal morbidity and mortality. Qualitative findings in Phase Oneindicated that there is a general lack of knowledge regarding chorioamnionitis among midwives, resulting ininadequate screening, misdiagnosis and mismanagement of the condition. Experienced medical practitioners confirmed that chorioamnionitis is underdiagnosed, misdiagnosed or undiagnosed and underreported,and they hold views that it is difficult to treat and control pregnancy-related infections according to current practice.An integrative literature review was conductedin Phase Twoand literature regarding diagnostic biomarkers, screening options to diagnose chorioamnionitis and management of chorioamnionitis were extracted. After evidence synthesisofPhase Oneand Phase Twodata, a best practice guidelinefor screening and managing viiwomen withchorioamnionitiswas developed usingthe National Institute for Health and Clinical Excellence guideline development approach in Phase Three. The purpose of the best practice guideline for screening and managing women with chorioamnionitis was to provide a guideline onhow to manage women who are at risk and those who present with signs and symptoms of chorioamnionitis at any stage during their pregnancy. Five recommendations were made that involve screening for chorioamnionitisand causative factors, biomarkers to diagnose chorioamnionitis, management of chorioamnionitis that includes pharmacological and…

Subjects/Keywords: Bacterial diseases

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APA (6^th Edition):

Du Plessis, A. H. (2020). A best practice guideline for screening and managing chorioamnionitis. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/46374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Du Plessis, Allison Herlene. “A best practice guideline for screening and managing chorioamnionitis.” 2020. Thesis, Nelson Mandela Metropolitan University. Accessed April 10, 2021. http://hdl.handle.net/10948/46374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Du Plessis, Allison Herlene. “A best practice guideline for screening and managing chorioamnionitis.” 2020. Web. 10 Apr 2021.

Vancouver:

Du Plessis AH. A best practice guideline for screening and managing chorioamnionitis. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10948/46374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Du Plessis AH. A best practice guideline for screening and managing chorioamnionitis. [Thesis]. Nelson Mandela Metropolitan University; 2020. Available from: http://hdl.handle.net/10948/46374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

10. Tadokera, Rabecca. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.

Degree: Image, Institute of Infectious Disease and Molecular Medicine, 2011, University of Cape Town

URL: http://hdl.handle.net/11427/11589

► While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome… (more)

Subjects/Keywords: Infectious Diseases

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APA (6^th Edition):

Tadokera, R. (2011). Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/11589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tadokera, Rabecca. “Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.” 2011. Thesis, University of Cape Town. Accessed April 10, 2021. http://hdl.handle.net/11427/11589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tadokera, Rabecca. “Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.” 2011. Web. 10 Apr 2021.

Vancouver:

Tadokera R. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11427/11589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tadokera R. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/11589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – East Bay

11. Lau, Henry Ka Chang. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.

Degree: 2013, California State University – East Bay

URL: http://hdl.handle.net/10211.3/98350

► It is difficult to isolate target bacteria in high background microbiota food matrices. This is certainly the case for isolating Shigellae from foods such as… (more)

▼ It is difficult to isolate target bacteria in high background microbiota food matrices. This is certainly the case for isolating Shigellae from foods such as apple juice, potato salad, bagged peeled carrots, whole romaine lettuce, alfalfa sprouts, and green onions. A comparison of current methods was performed using USFDA Bacterial Analytical Method (BAM), USFDA 2009 modified Produce Assignment, Pathatrix IMS, and KingFisher Flex. Using the results from the comparisons, a novel streamlined method named Pathatrix-KingFisher was created for detecting and isolating Shigellae in green onions. The Immunomagnetic Separation (IMS) technology used by Pathatrix Auto and KingFisher Flex instruments aided in screening and recovery of Shigellae. Furthermore, a direct comparison of the USFDA 2009 modified Produce Assignment with my novel Pathatrix-KingFisher method on green onions was performed. Food samples were artificially inoculated with < 30 CFU/25 g of a previously -80??C frozen Shigella flexneri 2457M culture, and compared with no-spike controls and no-matrix controls. All methods were evaluated at 5 h and/or 24 h post-incubation for their detection and isolation efficacy. Presumptive positive isolates were confirmed to be Shigellae using TSI slants and/or qPCR with primers to the Shigellae specific ipaH gene. The USFDA BAM method was able to detect and recover Shigellae on processed foods (for example, apple juice, potato salad, bagged peeled carrots, whole romaine lettuce), but not for food with high background microbiota (for example, alfalfa sprouts and green onions). The USFDA 2009 modified Produce Assignment method was inconsistent at detecting and isolating Shigellae from all foods. The Pathatrix IMS method was effective at detecting Shigellae in foods, but was ineffective at isolating Shigellae. Both the Pathatrix IMS and KingFisher Flex were able to detect Shigellae using qPCR consistently after 5 h of incubation. The recoveries at 5 h incubation, even with the help of IMS from the two instruments, were inconsistent. Shigellae were detected and isolated regularly after 24 h of incubation using the KingFisher Flex. When compared to the USFDA 2009 modified Produce Assignment method, both the IMS methods were more consistent in detecting and isolating Shigellae in green onions. By using both instruments, my novel method, Pathatrix-KingFisher, takes advantage of the sensitivity of Pathatrix Auto sample size and the automation of the KingFisher Flex???s 96- well format to generate consistent high-throughput results. Two automated platforms using immunomagnetic separation technology were compared for detecting and recovering Escherichia coli O157 in ground beef and sprouts and Shigella flexneri in green onions. The foods were inoculated with < 20 CFU/25 g and tested at 5 and 24 h post-incubation. Immunomagnetic beads were mixed with food enrichments, processed through the Pathatrix Auto or KingFisher Flex, and tested by realtime PCR (qPCR) and recovery on selective agars. At 5 h, the… Advisors/Committee Members: Baysdorfer, Dr. Christoph W. (advisor), Lauzon, Dr. Carol R. (primaryAdvisor).

Subjects/Keywords: Foodborne diseases

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APA (6^th Edition):

Lau, H. K. C. (2013). The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. (Thesis). California State University – East Bay. Retrieved from http://hdl.handle.net/10211.3/98350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Henry Ka Chang. “The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.” 2013. Thesis, California State University – East Bay. Accessed April 10, 2021. http://hdl.handle.net/10211.3/98350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Henry Ka Chang. “The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.” 2013. Web. 10 Apr 2021.

Vancouver:

Lau HKC. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. [Internet] [Thesis]. California State University – East Bay; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10211.3/98350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau HKC. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. [Thesis]. California State University – East Bay; 2013. Available from: http://hdl.handle.net/10211.3/98350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan Technological University

12. Huber, Mike. SALT SENSITIVE HYPERTENSION AND OREXIN.

Degree: MS, Department of Biological Sciences, 2016, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/267

► Elevated plasma arginine vasopressin (AVP) levels have been found in human hypertension subjects and several salt dependent experimental animal models of hypertension including the… (more)

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Huber, M. (2016). SALT SENSITIVE HYPERTENSION AND OREXIN. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/267

Chicago Manual of Style (16^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Masters Thesis, Michigan Technological University. Accessed April 10, 2021. https://digitalcommons.mtu.edu/etdr/267.

MLA Handbook (7^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Web. 10 Apr 2021.

Vancouver:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Internet] [Masters thesis]. Michigan Technological University; 2016. [cited 2021 Apr 10]. Available from: https://digitalcommons.mtu.edu/etdr/267.

Council of Science Editors:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Masters Thesis]. Michigan Technological University; 2016. Available from: https://digitalcommons.mtu.edu/etdr/267

13. Jones, Geraldine Brown. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.

Degree: 2015, Texas Woman's University

URL: http://hdl.handle.net/11274/7047

► The purpose of this hermeneutic phenomenological study was to explore elderly patients perspectives regarding discharge instructions related to self-management of their chronic illnesses once they… (more)

▼ The purpose of this hermeneutic phenomenological study was to explore elderly patients perspectives regarding discharge instructions related to self-management of their chronic illnesses once they were discharged from the hospital to their home. The combination of the growing elderly population, inadequate health literacy, and the prevalence of comorbidity illustrate the complex needs of this population of patient in regards to self-management of chronic illnesses once discharged (National Research Council of the National Academies, 2012). Study participants were recruited from two cardiovascular hospital-based clinics located in a large medical center in Texas. A purposive sampling was used to secure a sample of 20 participants meeting the following inclusion criteria: older than 65 years of age, diagnosis of any type of cardiovascular disease, cognitive competence, length of stay in the hospital greater than 3 days, discharged home rather than to long term care facility or nursing home, first follow-up doctor visit 2-4 weeks after discharge from the hospital and English speaking. </DISS_para> <DISS_para>Data were collected using a demographic questionnaire, a cognitive screening test (Mini Cog) and semi-structured audio-recorded interviews that lasted approximately 30-45 minutes. Trustworthiness was established using Lincoln and Guba s framework (1985) to secure credibility, transferability, dependability, and confirmability. Analysis was conducted using the Lindseth and Norberg s (2004) hermeneutical interpretation method which includes three steps: naïve reading, structural analysis and comprehensive understanding. A major finding was that patients perceptions of their discharge instructions did not match the reality of their post-discharge needs. Four themes emerged, reflecting aspects about transition from hospital to home: Just-in-time Discharge Process, I Thought the Instructions Were Good, But , What Would I do Without My Caregiver, and It Would Help If I Had This study identified gaps in discharge instructions and the degree to which they did or failed to prepare elderly patients to self-manage their chronic illness once discharged home. Such gaps potentially result in poor self-management and subsequent rehospitalization. Without strengthening the hospital discharge instruction process, self-management of illness in the elderly patient population will continue to be a major challenge. Advisors/Committee Members: Young, Anne (advisor), Symes, Lene (advisor), Cesareo, Sandra (advisor).

Subjects/Keywords: Chronic diseases

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APA (6^th Edition):

Jones, G. B. (2015). Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. (Thesis). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Geraldine Brown. “Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.” 2015. Thesis, Texas Woman's University. Accessed April 10, 2021. http://hdl.handle.net/11274/7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Geraldine Brown. “Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.” 2015. Web. 10 Apr 2021.

Vancouver:

Jones GB. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. [Internet] [Thesis]. Texas Woman's University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11274/7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones GB. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. [Thesis]. Texas Woman's University; 2015. Available from: http://hdl.handle.net/11274/7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

14. Lim, Nastasia Kuan-Hong. CuII(atsm) as a potential therapeutic for neurodegenerative diseases.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/39732

► Neurodegenerative disease is caused by a progressive deterioration of cells in the central nervous system. Commonly known neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease… (more)

▼ Neurodegenerative disease is caused by a progressive deterioration of cells in the central nervous system. Commonly known neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal lobar degeneration (FTLD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). These diseases are all fatal and do not have effective therapeutics. Through the use of various models of neurodegenerative disease, metallocomplexes of bis(thiosemicarbazones) have been identified with a strong therapeutic potential. Of these compounds, diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) has demonstrated the best potential as a treatment for a broad range of neurodegenerative diseases. Treating with CuII(atsm) has thus far shown to attenuate disease symptoms in multiple mouse models of PD and a mouse model of ALS. This project therefore aimed to determine the broader therapeutic activity of CuII(atsm), by examining its therapeutic effects in additional mouse models of neurodegenerative disease. Treatment with CuII(atsm) at a daily dose of 30mg per kg of body weight to the SOD1G37R mouse model of ALS, the TDP-43A315T mouse model of FTLD/ALS and the R6/1 mouse model of HD, showed CuII(atsm) was only able to improve the disease phenotype of the SOD1G37R mice. Treatment with CuII(atsm) improved the survival of the SOD1G37R mice by 16% and their locomotor deficit, however there was no phenotypic change of symptoms with CuII(atsm) treatment in the TDP-43A315T or R6/1 mice. Biochemically, treating with CuII(atsm) decreased markers of inflammation and/or oxidative damage in all of the mouse models analysed. Given that CuII(atsm) treatment only improved the phenotype of one of the animal models analysed, suggest the suppression of the inflammatory and oxidative damage pathways in isolation in these animal models of disease are insufficient for CuII(atsm) to mediate its therapeutic effects. Although treatment with CuII(atsm) in the SOD1G37R mice attenuated disease symptoms and improved survival, the treatment also paradoxically increased levels of the ALS-causing mutant form of the copper/zinc containing superoxide dismutase 1 (SOD1). To investigate this paradox, mass spectrometry was utilised to analyse how increasing levels of the putative pathogenic mutant SOD1 could decrease disease symptoms in the SOD1G37R mice. For its normal function, SOD1 requires one copper and one zinc ion per subunit, but analysis of the ALS model mice spinal cord showed a majority of the SOD1 was copper-deficient. Treatment with CuII(atsm) increased the copper content of the mutant SOD1 and consequently, increased the fully-metallated, non-toxic and stable form of mutant SOD1. Thus, increasing the bioavailability of metals and improving the aberrant metallation states of pathogenic metalloproteins may be a part of the therapeutic activity of CuII(atsm). Overall, outcomes…

Subjects/Keywords: neurodegenerative diseases

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APA (6^th Edition):

Lim, N. K. (2013). CuII(atsm) as a potential therapeutic for neurodegenerative diseases. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/39732

Chicago Manual of Style (16^th Edition):

Lim, Nastasia Kuan-Hong. “CuII(atsm) as a potential therapeutic for neurodegenerative diseases.” 2013. Doctoral Dissertation, University of Melbourne. Accessed April 10, 2021. http://hdl.handle.net/11343/39732.

MLA Handbook (7^th Edition):

Lim, Nastasia Kuan-Hong. “CuII(atsm) as a potential therapeutic for neurodegenerative diseases.” 2013. Web. 10 Apr 2021.

Vancouver:

Lim NK. CuII(atsm) as a potential therapeutic for neurodegenerative diseases. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11343/39732.

Council of Science Editors:

Lim NK. CuII(atsm) as a potential therapeutic for neurodegenerative diseases. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/39732

15. Duff, Jed. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.

Degree: PhD, 2013, Australian Catholic University

URL: https://researchbank.acu.edu.au/theses/448

► Venous thromboembolism (VTE) is the umbrella term covering deep vein thrombosis, pulmonary embolism and a group of associated chronic conditions. This vascular disease process… (more)

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Duff, J. (2013). Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. (Doctoral Dissertation). Australian Catholic University. Retrieved from https://researchbank.acu.edu.au/theses/448

Chicago Manual of Style (16^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Doctoral Dissertation, Australian Catholic University. Accessed April 10, 2021. https://researchbank.acu.edu.au/theses/448.

MLA Handbook (7^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Web. 10 Apr 2021.

Vancouver:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Internet] [Doctoral dissertation]. Australian Catholic University; 2013. [cited 2021 Apr 10]. Available from: https://researchbank.acu.edu.au/theses/448.

Council of Science Editors:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Doctoral Dissertation]. Australian Catholic University; 2013. Available from: https://researchbank.acu.edu.au/theses/448

University of Central Florida

16. Horton, Julie. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.

Degree: 2017, University of Central Florida

URL: https://stars.library.ucf.edu/etd/5697

► Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the… (more)

▼ Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the heart to adequately execute requisite pump function in order to deliver nutrients and oxygen to peripheral tissues, irrespective of etiology. One of the most common causes of HF is chronic pressure overload due to hypertension. Ischemic heart disease is also a common driver of HF, often in conjunction with hypertension. Pressure overload initially causes compensatory metabolic changes. Structural changes follow shortly thereafter typically resulting in left ventricular hypertrophy. Eventually, the heart loses the ability to compensate for the aberrant hemodynamic load and begins failing. The failing heart is unable to supply adequate adenosine triphosphate (ATP) for contractile function as evidenced by falling phosphocreatine (PCr) levels. This energy deficit occurs concurrently with a metabolic re-programming that results in a fuel utilization pattern resembling the fetal heart. Notably, enzymes involved in catabolism of fatty acids, the chief fuel substrate for ATP generation in the normal adult heart, are downregulated in the failing heart. However, the extent to which alternative fuels compensate for decreased fatty acid oxidation (FAO) is not well-known. Furthermore, consequences of the fuel substrate switches that occur in heart failure are not well established. In this work, we discover a new paradigm for alternate fuel utilization in the failing heart and define consequences of altered fuel metabolism in HF. We discovered a post-translational modification resultant from an accumulation of acetyl groups (C2) present in a mouse model of early-stage HF and human HF. Mitochondrial proteins were found to be hyperacetylated in the failing heart, and at least some of these alterations result in diminished electron-transport chain (ETC) capacity as shown by mutagenesis studies on succinate dehydrogenase A (SDHA). We also found an accumulation of C4-OH carnitine, a by-product of ketone oxidation in HF. This metabolite aggregation occurred alongside an increase in b-hydroxybutyrate dehydrogenase 1 (BDH1) transcript and protein levels. This signature suggested that the failing heart shifted to ketone bodies as a fuel. Subsequent experiments confirmed increased capacity for myocardial ketone oxidation in compensated cardiac hypertrophy and in HF. The consequences of increased ketone oxidation were then assessed using a cardiac-specific BDH1 knockout (BDH1 KO) mouse. Despite not having any apparent defect at baseline, we found BDH1 KO mouse hearts are completely unable to oxidize 3-hydroxybutyrate. The deficit for ketone oxidation capacity became consequential upon subjugation to transverse aortic constriction with a small apical myocardial infarction (TAC/MI). The BDH1 KO mice exhibit altered pathological cardiac remodeling compared to wild-type controls. These latter data suggest the increased reliance on ketone oxidation in HF, mediated by BDH1, is an adaptive… Advisors/Committee Members: Estevez, Alvaro.

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Horton, J. (2017). Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. (Doctoral Dissertation). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/5697

Chicago Manual of Style (16^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Doctoral Dissertation, University of Central Florida. Accessed April 10, 2021. https://stars.library.ucf.edu/etd/5697.

MLA Handbook (7^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Web. 10 Apr 2021.

Vancouver:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Internet] [Doctoral dissertation]. University of Central Florida; 2017. [cited 2021 Apr 10]. Available from: https://stars.library.ucf.edu/etd/5697.

Council of Science Editors:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Doctoral Dissertation]. University of Central Florida; 2017. Available from: https://stars.library.ucf.edu/etd/5697

17. Hill, Edward. Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology.

Degree: PhD, 2020, Australian Catholic University

URL: https://researchbank.acu.edu.au/theses/831

► Projections estimate 131.5 million will be living with dementia by the year 2050. Alzheimer’s disease is the leading cause of dementia, accounting for 60-70%… (more)

▼ Projections estimate 131.5 million will be living with dementia by the year 2050. Alzheimer’s disease is the leading cause of dementia, accounting for 60-70% of all cases and is a global public health priority. Alzheimer’s disease (AD) risk increases with age and lacks efficacious drugs. Pharmacological treatment is failing, leading to a growing body of research investigating the preventative potential of modifiable lifestyle risk factors, such as diet. Summaries of the existing evidence reveal an association between Mediterranean-style diet adherence and reduced AD incidence; however, no review has investigated this relationship with respect to the hallmark AD biomarkers that manifest decades prior to clinical symptomatology. Amassed evidence indicates associations between diet and Alzheimer’s disease may occur through biomarker pathways such as amyloid-β; however, very few studies have investigated dietary/ amyloid-β relationships and prior to this thesis, no study has investigated this relationship in a female only cohort. Chapters 1 and 2 examined the current literature regarding diet-AD relationship. Previous evidenc from systematic review suggests a relationship between dietary adherence and Alzheimer’s risk; however, this thesis provided the first meta-analytic evidence of this relationship extending to the prodromal phase of neuropathological change. A comprehensive systematic review and meta analysis into diet and Alzheimer’s biomarkers found a small but significant effect of diet on AD biomarkers. This review supported the notion that diet and nutrition display therapeutic potential for non-pharmacological lifestyle intervention. Chapters 4 and 5 investigated the changing nutritional and dietary habits of Australian ageing women over time. Participants from the longitudinal Women’s Healthy Ageing Project completed assessments, including a validated food frequency questionnaire, at two time-points 14 years apart (1998 and 2012). Energy intake significantly decreased over time, whilst energy-adjusted total fat, saturated fat, monounsaturated fat and cholesterol intakes all significantly increased. Three dietary patterns were identified at both time points; two ‘healthy-type’ patterns as well as a third less healthy pattern. In these women, although some participant’s dietary pattern remained largely stable over time, the majority of women underwent dietary pattern change over this time in their lives. Chapter 6 presented a cross-sectional analysis of the relationship between dietary pattern adherence and beta-amyloid deposition in participants of the Women’s Healthy Ageing Project. Adherence to the Junk Food dietary pattern was found to be a significant predictor of cerebral amyloid-β deposition, highlighting the importance of diet as a potentially modifiable lifestyle risk factor in the preclinical phase of Alzheimer’s disease. This thesis presented the first systematic review and meta analysis analysing diet-Alzheimer’s relations in the preclinical, neuropathological stage of disease progression. Given…

Subjects/Keywords: Diseases; Nutrition

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APA (6^th Edition):

Hill, E. (2020). Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology. (Doctoral Dissertation). Australian Catholic University. Retrieved from https://researchbank.acu.edu.au/theses/831

Chicago Manual of Style (16^th Edition):

Hill, Edward. “Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology.” 2020. Doctoral Dissertation, Australian Catholic University. Accessed April 10, 2021. https://researchbank.acu.edu.au/theses/831.

MLA Handbook (7^th Edition):

Hill, Edward. “Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology.” 2020. Web. 10 Apr 2021.

Vancouver:

Hill E. Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology. [Internet] [Doctoral dissertation]. Australian Catholic University; 2020. [cited 2021 Apr 10]. Available from: https://researchbank.acu.edu.au/theses/831.

Council of Science Editors:

Hill E. Preventive potential of diet in the pre-clinical phase of Alzheimer’s disease symptomatology. [Doctoral Dissertation]. Australian Catholic University; 2020. Available from: https://researchbank.acu.edu.au/theses/831

University of Zambia

18. Kakumbi, Bernard. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .

Degree: 2011, University of Zambia

URL: http://hdl.handle.net/123456789/445

► The effect of vesicular arbuscular mycorrhiza (VAM) and rhizosphere pseudomonads on chickpea (Cicer arietinum L.) wilt caused by Fusarium oxysporum f. sp. ciceri (Matuo and… (more)

▼ The effect of vesicular arbuscular mycorrhiza (VAM) and rhizosphere pseudomonads on chickpea (Cicer arietinum L.) wilt caused by Fusarium oxysporum f. sp. ciceri (Matuo and Sato) in Zambia was investigated. Vesicular arbuscular mycorrhiza was isolated from three soils obtained from Kasama area of Lusaka. Rhizosphere pseudomonads were isolated from a chickpea farm in the same area. Physical and chemical characteristics of the soils were analyzed. Both VAM and pseudomonads were characterized and identified. The mycorrhizal flora of the three soils consisted of Glomus etunicatum, Gigaspora nigra and Acaulospora scrobiculata. This composite mycorrhizal flora and rhizosphere pseudomonads were used to determine their effect on fusarium wilt of chickpea. Their effect on growth and productivity of the crop was also investigated. The study was carried out between December 2006 and April 2007 in a greenhouse at the School of Agriculture of the University of Zambia. The VAM flora was amplified for a period of eight weeks by planting surface sterilized seeds of maize variety MMV 600 in heat sterilized soil. Vesicular arbuscular mycorrhiza soil inoculums was mixed in proportions of 3 sterilized soil to 1 VAM soil portion (1 portion equals 1.5kg amplified VAM soil) for use in two of the four treatments. A complete randomized block experimental block design was used with four treatments and four replications. Surface disinfected SPGR-4869 chickpea seeds were planted in the soil mixtures in plastic pots in a greenhouse. The four treatments consisted of the following: A. A combination of fusarium wilts pathogen, sterilized soil and chickpea seeds. B. Fusarium wilt pathogen, pseudomonads, sterilized soil and chickpea seeds. C. Fusarium wilt pathogen, VAM, sterilized soil and chickpea seeds. D. Fusarium wilt pathogen, pseudomonads, VAM, sterilized soil and chickpea seeds. A conidial suspension of 2 cm containing 5.07 x 104 micro conidia of Fusarium oxysporum f.sp. ciceri were inoculated per plant at the time of sowing. For treatments C and D colony forming units (cfu) of 105 of pseudomonad bacterial extract (turbidity 27.20 mg/L at 430nm) was inoculated per plant. The plants were watered with tap water at intervals of 48 hours. Chickpea plants were examined at fifteen days intervals from 15 to 90 days after sowing (DAS) to measure plant height, the number of leaves, flowers and pods per plant. At 90 (DAS) seed weight per plant, fresh shoot weight, fresh root weight and disease incidence were recorded. The results show that there was 52% reduction of fusarium wilt in chickpea inoculated with VAM and pseudomonads (dual inoculation) compared to the control. Single inoculation of VAM showed 50% reduction of fusarium wilt in chickpea plants. The analysis of variance (ANOVA) of the measured parameters indicated that the dual inoculation (VAM and pseudomonads) enhanced growth and development of chickpea plants by 16% compared to the control and produced taller plants with more leaves, flowers and a high shoot and…

Subjects/Keywords: Plant Diseases – Zambia; Plant Diseases – Diagnosis – Zambia

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APA (6^th Edition):

Kakumbi, B. (2011). The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kakumbi, Bernard. “The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .” 2011. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kakumbi, Bernard. “The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .” 2011. Web. 10 Apr 2021.

Vancouver:

Kakumbi B. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . [Internet] [Thesis]. University of Zambia; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kakumbi B. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . [Thesis]. University of Zambia; 2011. Available from: http://hdl.handle.net/123456789/445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

19. Benjamin, Jamaal Louis. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1571

► The intestines of all mammals are colonized with a diverse microbiota that provide metabolic benefits to their hosts. However, this symbiotic relationship can break down… (more)

Subjects/Keywords: Inflammatory Bowel Diseases; Autophagy; Intestinal Diseases

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APA (6^th Edition):

Benjamin, J. L. (2013). Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Benjamin, Jamaal Louis. “Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed April 10, 2021. http://hdl.handle.net/2152.5/1571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Benjamin, Jamaal Louis. “Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.” 2013. Web. 10 Apr 2021.

Vancouver:

Benjamin JL. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2152.5/1571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Benjamin JL. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Kakandelwa, Cliff. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.

Degree: 2015, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4185

► Giardia is an intestinal protozoan parasite of mammals including humans. The objectives of the cross sectional study conducted between May 2013 and April 2014 were… (more)

▼ Giardia is an intestinal protozoan parasite of mammals including humans. The objectives of the cross sectional study conducted between May 2013 and April 2014 were to estimate the prevalence of Giardia infections in dairy herds on farms in Chilanga and Lusaka districts of Lusaka Province, Zambia, and to evaluate risk factors associated with the infections. Farms were grouped into smallholder and commercial farms. A total of 377 calves aged one day to one year were sampled from 34 farms. All the 377 faecal samples were analyzed for Giardia antigen using a commercially available monoclonal antibody-based Enzyme-linked immunosorbent assay kit. Chi square and Fisher’s exact tests were used and binary logistic regression was used to evaluate factors associated with infections. The overall prevalence of Giardia for the two districts was 34.5% (130/377; 95% CI= 29.7-39.3) while the overall farm prevalence was 79.4% (27/34). For individual smallholder farms, the animal level prevalence of Giardia ranged from zero to 100% and within commercial herds, it was 12.5% to 60.9%. The prevalence was significantly higher in calves up to three months old than in older ones (p = 0.010). There was no significant difference in the prevalence of Giardia between smallholder and commercial dairy farms (p = 0.300) and this was also the case between male and female calves (p = 0.633). The present study did not find a clear association between presence of Giardia in faecal samples and occurrence of diarrhoea in calves (p = 0.205). v Several management factors were evaluated, however, only husbandry system was found to be a significant risk factor for infection with the parasite. It was found that herds reared under intensive husbandry system were 2.083 (95% CI = 1.086-59.308, p = 0.041) times more likely to be positive for Giardia than those under free range system. The findings of the present study demonstrate that Giardia infections are common in dairy herds in Chilanga and Lusaka districts especially in calves up to three months of age which may play an important role in the epidemiology of giardiasis. Furthermore, husbandry system is an important factor in the perpetuation of the infections.

Subjects/Keywords: GIARDIA Infections; Cattle Diseases; Domestic Animals-Diseases

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APA (6^th Edition):

Kakandelwa, C. (2015). Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kakandelwa, Cliff. “Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.” 2015. Thesis, University of Zimbabwe. Accessed April 10, 2021. http://dspace.unza.zm/handle/123456789/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kakandelwa, Cliff. “Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.” 2015. Web. 10 Apr 2021.

Vancouver:

Kakandelwa C. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2021 Apr 10]. Available from: http://dspace.unza.zm/handle/123456789/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kakandelwa C. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

21. Allardyce, Jane. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.

Degree: School of Life and Environmental Sciences, 2011, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30036706

► The plant pathogen <i>Phytophthora cinnamomi </i>causes devastating disease in natural and agricultural systems worldwide. While some plants can survive, little is known about the… (more)

Subjects/Keywords: plant pathology; plant diseases; ‬phytophthora cinnamomi diseases

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APA (6^th Edition):

Allardyce, J. (2011). Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30036706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Allardyce, Jane. “Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.” 2011. Thesis, Deakin University. Accessed April 10, 2021. http://hdl.handle.net/10536/DRO/DU:30036706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Allardyce, Jane. “Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.” 2011. Web. 10 Apr 2021.

Vancouver:

Allardyce J. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. [Internet] [Thesis]. Deakin University; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10536/DRO/DU:30036706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Allardyce J. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. [Thesis]. Deakin University; 2011. Available from: http://hdl.handle.net/10536/DRO/DU:30036706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

22. Zani, Stavrina. Pharmacotherapy Of Autoimmune Diseases .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194730

► Autoimmune diseases are chronic, potential life threatening multisystem disorders which attack an individual's own immune system and destroy healthy cells and tissues.Autoimmune diseases are classified… (more)

Subjects/Keywords: Autoimmune Diseases; Treatment Of Autoimmune Diseases

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APA (6^th Edition):

Zani, S. (2014). Pharmacotherapy Of Autoimmune Diseases . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zani, Stavrina. “Pharmacotherapy Of Autoimmune Diseases .” 2014. Thesis, University of Debrecen. Accessed April 10, 2021. http://hdl.handle.net/2437/194730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zani, Stavrina. “Pharmacotherapy Of Autoimmune Diseases .” 2014. Web. 10 Apr 2021.

Vancouver:

Zani S. Pharmacotherapy Of Autoimmune Diseases . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2437/194730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zani S. Pharmacotherapy Of Autoimmune Diseases . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Greene, Daniel, John. Methods for Determining the Genetic Causes of Rare Diseases.

Degree: PhD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/270546

► Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel… (more)

▼ Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel disease aetiologies, increase our understanding of biological processes and improve patient care. However, the power to discover the genetic causes of many unexplained rare diseases is hindered by a paucity of cases with a shared molecular aetiology. This thesis presents research into statistical and computational methods for determining the genetic causes of rare diseases. Methods described herein treat important aspects of the nature of rare diseases, including genetic and phenotypic heterogeneity, phenotypes involving multiple organ systems, Mendelian modes of inheritance and the incorporation of complex prior information such as model organism phenotypes and evolutionary conservation. The complex nature of rare disease phenotypes and the need to aggregate patient data across many centres has led to the adoption of the Human Phenotype Ontology (HPO) as a means of coding patient phenotypes. The HPO provides a standardised vocabulary and captures relationships between disease features. I developed a suite of software packages dubbed 'ontologyX' in order to simplify analysis and visualisation of such ontologically encoded data, and enable them to be incorporated into complex analysis methods. An important aspect of the analysis of ontological data is quantifying the semantic similarity between ontologically annotated entities, which is implemented in the ontologyX software. We employed this functionality in a phenotypic similarity regression framework, 'SimReg', which models the relationship between ontologically encoded patient phenotypes of individuals and rare variation in a given genomic locus. It does so by evaluating support for a model under which the probability that a person carries rare alleles in a locus depends on the similarity between the person's ontologically encoded phenotype and a latent characteristic phenotype which can be inferred from data. A probability of association is computed by comparison of the two models, allowing prioritisation of candidate loci for involvement in disease with respect to a heterogeneous collection of disease phenotypes. SimReg includes a sophisticated treatment of HPO-coded phenotypic data but dichotomises the genetic data at a locus. Therefore, we developed an additional method, 'BeviMed', standing for Bayesian Evaluation of Variant Involvement in Mendelian Disease, which evaluates the evidence of association between allele configurations across rare variants within a genomic locus and a case/control label. It is capable of inferring the probability of association, and conditional on association, the probability of each mode of inheritance and probability of involvement of each variant. Inference is performed through a Bayesian comparison of multiple models: under a baseline model disease risk is independent of allele configuration at the given rare variant sites and under an alternate model…

Subjects/Keywords: Bayesian statistics; Rare diseases; Ontologies; Genetic diseases

5 more images…

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APA (6^th Edition):

Greene, Daniel, J. (2018). Methods for Determining the Genetic Causes of Rare Diseases. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/270546

Chicago Manual of Style (16^th Edition):

Greene, Daniel, John. “Methods for Determining the Genetic Causes of Rare Diseases.” 2018. Doctoral Dissertation, University of Cambridge. Accessed April 10, 2021. https://www.repository.cam.ac.uk/handle/1810/270546.

MLA Handbook (7^th Edition):

Greene, Daniel, John. “Methods for Determining the Genetic Causes of Rare Diseases.” 2018. Web. 10 Apr 2021.

Vancouver:

Greene, Daniel J. Methods for Determining the Genetic Causes of Rare Diseases. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Apr 10]. Available from: https://www.repository.cam.ac.uk/handle/1810/270546.

Council of Science Editors:

Greene, Daniel J. Methods for Determining the Genetic Causes of Rare Diseases. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/270546

Tartu University

24. Raam, Liisi. Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis .

Degree: 2020, Tartu University

URL: http://hdl.handle.net/10062/69716

► Vitiliigo on krooniline nahahaigus, mis väljendub valgete laikudena nahal. Vitiliigo mõjutab patsiendi elukvaliteeti, sest avaldub tihti lapse- ja noorukieas ning haiguskolded paigutuvad enamasti avatud kehapiirkondadesse.… (more)

▼ Vitiliigo on krooniline nahahaigus, mis väljendub valgete laikudena nahal. Vitiliigo mõjutab patsiendi elukvaliteeti, sest avaldub tihti lapse- ja noorukieas ning haiguskolded paigutuvad enamasti avatud kehapiirkondadesse. Puudulikud teadmised vitiliigo tekkemehhanismidest on takistanud tõhusate ravimeetodite väljatöötamist. Psoriaas on sage krooniline põletikuline haigus, mis väljendub punetavate ja ketendavate haiguskolletena nahal, millele võib kaasneda küünte ja liigeste kahjustus. Kuigi bioloogilise ravi kasutuselevõtt on psoriaasi ravitulemusi parandanud, ei toimi see kõigil haigetel võrdväärselt tõhusalt ning senini ei osata ravitulemust ega haiguse kulgu täielikult ette ennustada. Selleks, et hankida uut informatsiooni vitiliigo ja psoriaasi tekkemehhanismide kohta, kaasasime uuringusse 23 vitiliigot ja 43 psoriaasi põdevat patsienti ning 32 tervet vabatahtlikku. Määrasime uuritavate nahast ja verest immuunsüsteemi töös osalevate geenide ja valkude avaldumist. Lisaks uurisime vitiliigoga haigete nahas mikroRNAde avaldumist. MikroRNAd on väikesed, aga võimsad pärilikkusaine osakesed, mis mõjutavad geenide avaldumist ja seoses sellega kaudselt kõiki protsesse organismis. Kui varasemalt arvati, et nii vitiliigo kui ka psoriaas on peamiselt autoimmuunsed haigused, st. et häirunud on eeskätt omandatud immuunsus, siis meie uuringus ilmnes, et häirunud on ka mitmed etapid kaasasündinud immuunsuse töös. See on immuunsüsteemi osa, mis on pidevas valmisolekus, et kaitsta organismi väliskeskkonnast pärinevate ohtude eest. Teiseks leidsime, et vitiliigo korral on nii pigmendi- kui ka naharakkudes aktiveerunud protsess nimega autofaagia, mille käigus õgitakse ära rakkude vigased koostisosad. Kolmandaks tuvastasime, et vitiliigot põdevate patsientide nahas on muutunud paljude mikroRNAde, mis osalevad pigmenditootmises ja põletikuprotsessis, avaldumine. Kui viisime ühe nendest mikroRNAdest pigmendi- ja naharakkude sisse, muutus omakorda paljude põletikus ja pigmenditootmises osalevate geenide avaldumine. Antud uurimistöö tulemused näitavad, et tulevikus on tarvis lisauuringuid selgitamaks kaasasündinud immuunsüsteemi, autofaagia ja mikroRNAde rolli vitiliigo ja psoriaasi kulgu ennustavate markeritena, diagnostiliste markeritena ja ravi märklaudadena.; Vitiligo is a chronic skin disease that manifests as white spots on the skin. As the onset of vitiligo is often during childhood or adolescence and white spots mostly locate on visible body parts, vitiligo affects the quality of life. Lack of knowledge about the pathogenesis of vitiligo has impeded the development of effective methods of treatment. Psoriasis is a common chronic inflammatory disease that is characterized by red and scaly patches on the skin and often also by nail changes and joint inflammation. Biological therapy has improved the results of the treatment but the treatment is not always effective and to date we are unable to predict the results and the course of the disease. In order to obtain new information about the mechanisms of these diseases, we… Advisors/Committee Members: Kingo, Külli, juhendaja (advisor), Kisand, Kai, juhendaja (advisor), Rebane, Ana, juhendaja (advisor).

Subjects/Keywords: vitiligo; psoriasis; chronic diseases; skin diseases; pathogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raam, L. (2020). Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis . (Thesis). Tartu University. Retrieved from http://hdl.handle.net/10062/69716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raam, Liisi. “Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis .” 2020. Thesis, Tartu University. Accessed April 10, 2021. http://hdl.handle.net/10062/69716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raam, Liisi. “Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis .” 2020. Web. 10 Apr 2021.

Vancouver:

Raam L. Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis . [Internet] [Thesis]. Tartu University; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10062/69716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raam L. Molecular alterations in the pathogenesis of two chronic dermatoses – vitiligo and psoriasis . [Thesis]. Tartu University; 2020. Available from: http://hdl.handle.net/10062/69716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University

25. Bueno, Rudolfo. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.

Degree: Master of Veterinary Studies, 2015, Massey University

URL: http://hdl.handle.net/10179/6805

► Ostreid herpesvirus-1 (OsHV-1) was associated with summer mortalities in New Zealand Pacific oysters in 2010-2011. During the mortality investigation, a cohort of Pacific oyster spat,… (more)

Subjects/Keywords: Pacific oysters; Crassostrea gigas; Diseases; Herpesvirus diseases

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APA (6^th Edition):

Bueno, R. (2015). Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/6805

Chicago Manual of Style (16^th Edition):

Bueno, Rudolfo. “Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.” 2015. Masters Thesis, Massey University. Accessed April 10, 2021. http://hdl.handle.net/10179/6805.

MLA Handbook (7^th Edition):

Bueno, Rudolfo. “Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.” 2015. Web. 10 Apr 2021.

Vancouver:

Bueno R. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. [Internet] [Masters thesis]. Massey University; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10179/6805.

Council of Science Editors:

Bueno R. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. [Masters Thesis]. Massey University; 2015. Available from: http://hdl.handle.net/10179/6805

Rutgers University

26. Pyne, Robert M., 1988-. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).

Degree: PhD, Plant Biology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

►

Sweet basil (Ocimum basilicum) is among the most widely cultivated culinary herbs in the United States, Western Europe and Israel. Despite relative economic importance, breeding… (more)

▼

Sweet basil (Ocimum basilicum) is among the most widely cultivated culinary herbs in the United States, Western Europe and Israel. Despite relative economic importance, breeding and genetic study of this plant species has been largely neglected, rendering its >3 Gbp genome largely unexplored. The deficit in available O. basilicum genetic and genomic resources has been highlighted by a worldwide downy mildew epidemic caused by obligate oomycete Peronospora belbahrii, which has yet to be mediated by disease resistant varieties. The goal of this dissertation research was to narrow the information gap preventing an effective disease resistance breeding response. Specific objectives were to: 1) determine population structure and estimate genetic diversity among a panel of downy mildew resistant and susceptible Ocimum spp. accessions, 2) identify mode of inheritance for resistance to downy mildew in a full-sibling family and 3) construct a linkage map for detection of quantitative trait loci (QTL) associated with DM resistance. A nested, model-based cluster analysis demonstrated three major delineations within the Ocimum genus with additional evidence for cryptic structure, especially within the economically important k1 O. basilicum cluster. Distribution of DM resistance was concentrated outside the k1 O. basilicum cluster with the exception of a single k1 genotype, ‘MRI’. Analysis of downy mildew response across F2 and backcross populations over two years and two locations demonstrated major gene control of downy mildew resistance conferred by MRI. Finally, a restriction site associated DNA sequencing (RADseq) approach facilitated the discovery and mapping of >1,800 single nucleotide polymorphism (SNP) and expressed sequence tag simple sequence repeat (EST-SSR) markers. The resulting genetic map was validated by the detection of a major QTL, dm11.1, which explained 38-55% of the phenotypic variance observed for the MRI x SB22 F2 mapping population. Disomic inheritance of SNP and SSR markers support previous cytological evidence that basil has evolved an allopolyploid genome. Results of this dissertation provide the most robust phylogenetic examination of the Ocimum genus to date, characterization of DM heritability across multiple environments and the first report of genetic/QTL mapping for O. basilicum. A current case study is provided for the feasibility of breeding a non-model plant species using classical genetic theory in combination with modern genomic technologies.

Advisors/Committee Members: Simon, James (chair), Bonos, Stacy (internal member), Wyenandt, Andrew (internal member), Wehner, Todd (outside member).

Subjects/Keywords: Basil – Diseases and pests; Downy mildew diseases

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APA (6^th Edition):

Pyne, Robert M., 1. (2017). Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

Chicago Manual of Style (16^th Edition):

Pyne, Robert M., 1988-. “Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).” 2017. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/53965/.

MLA Handbook (7^th Edition):

Pyne, Robert M., 1988-. “Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).” 2017. Web. 10 Apr 2021.

Vancouver:

Pyne, Robert M. 1. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/.

Council of Science Editors:

Pyne, Robert M. 1. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

Rutgers University

27. Santorelli, Melissa L., 1975-. Chronic disease outcomes among older women with breast cancer in the united states.

Degree: PhD, Public Health, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

►

Context: Improving survival has raised important questions about the long term health of breast cancer patients, particularly for older women who experience the highest incidence… (more)

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Context: Improving survival has raised important questions about the long term health of breast cancer patients, particularly for older women who experience the highest incidence and who are more likely to have or develop other chronic health conditions. Specific Aims: The specific aims of this dissertation were to: 1) Examine racial differences in the effects of comorbidity on survival in elderly breast cancer patients (Study 1); 2) Investigate the effects of breast cancer on chronic disease medication adherence in the elderly (Study 2); and 3) Investigate the effects of hormonal therapy for breast cancer on diabetes incidence in postmenopausal women (Study 3). Design, Setting, and Subjects: The Surveillance, Epidemiology and End Results (SEER) – Medicare linked data were used to select stage I-III breast cancer patients for the above retrospective cohort studies. Women from a 5% random sample of Medicare enrollees living in SEER areas were selected as comparison subjects for studies two and three. Results: A competing risk survival analysis in the first study failed to find racial differences in the effects of comorbidity on breast cancer mortality after adjusting for age, year of diagnosis, and tumor characteristics. For other-cause mortality, the magnitude of adverse comorbidity effects were larger for white women overall (p=0.04). The second study showed an elevated risk of diabetes medication non-adherence for breast cancer versus comparison women after adjusting for age and race [Odds Ratio (OR) = 1.41; 95% Confidence Interval (CI) = 1.05 to 1.90]. Women with breast cancer were also more likely to be non-persistent with diabetes medication relative to women without cancer [Hazard Ratio (HR) = 1.29; 95% CI: 1.02 to 1.62]. The third study found no association between aromatase inhibitor use and new onset diabetes in the two years post-treatment initiation after adjusting for age, race, and comorbidity [HR: 0.99; 95% CI: 0.84 to 1.18]. Conclusion: The findings of this dissertation provide evidence that breast cancer affects chronic disease medication adherence and that hormonal therapy was not associated with the development of a new comorbidity. Special attention should be given to following breast cancer patients to ensure treatment of their comorbid conditions.

Advisors/Committee Members: DEMISSIE, KITAW (chair), Steinberg, Michael B (internal member), Rhoads, George G (internal member), LIN, YONG (internal member), Hirshfield, Kim M (outside member).

Subjects/Keywords: Chronic diseases; Breast – Cancer; Older women – Diseases

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APA (6^th Edition):

Santorelli, Melissa L., 1. (2015). Chronic disease outcomes among older women with breast cancer in the united states. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

Chicago Manual of Style (16^th Edition):

Santorelli, Melissa L., 1975-. “Chronic disease outcomes among older women with breast cancer in the united states.” 2015. Doctoral Dissertation, Rutgers University. Accessed April 10, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/47575/.

MLA Handbook (7^th Edition):

Santorelli, Melissa L., 1975-. “Chronic disease outcomes among older women with breast cancer in the united states.” 2015. Web. 10 Apr 2021.

Vancouver:

Santorelli, Melissa L. 1. Chronic disease outcomes among older women with breast cancer in the united states. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Apr 10]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/.

Council of Science Editors:

Santorelli, Melissa L. 1. Chronic disease outcomes among older women with breast cancer in the united states. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

University of Missouri – Columbia

28. Gilliam, Douglas H., Jr., 1983-. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.

Degree: 2016, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/56525

► The genome of Canis lupus familiaris, the domestic dog, is an ideal tool for the study of inherited diseases. Its genome is uniquely suited for… (more)

▼ The genome of Canis lupus familiaris, the domestic dog, is an ideal tool for the study of inherited diseases. Its genome is uniquely suited for the mapping of genes that cause disease, and its reference genome has been published since 2008. Dogs and humans share many of the same diseases, making them an ideal model for the study of comparative genetics. The identification of disease-causing genes in dogs has relevance to human health. We here describe the identification of causal mutations for three different canine diseases in orthologs of genes with orthologous human diseases. We used Next Generation Sequencing in order to generate Whole Genome Sequences for 145 dogs from 69 different breeds with various inherited canine diseases, most of which were suspected to be inherited recessively. We here report the discovery of the causes of; Spinocerebellar Ataxia with Myokymia and Seizures in Russell-Group Terriers, Neuronal Ceroid Lipofuscinosis in Golden Retrievers and Dilated Cardiomyopathy in Standard Schnauzers. While all three were identified via whole genome sequencing, different methodologies and techniques were used to discover and validate the findings. We discuss the importance of these studies and suggest future studies for the projects as well as possible other means of discovering potential canine disease models via Whole Genome Sequencing. Summaries of these three findings are provided in the next three paragraphs. Juvenile-onset spinocerebellar ataxia has been recognized in Jack Russell Terriers and related Russell group terriers (RGTs) for over 40 years. Ataxia occurs with varying combinations of myokymia, seizures and other signs, thus more than one form of the disease has been suspected. Our objective was to identify the mutation causing the spinocerebellar ataxia associated with myokymia and/or seizures and distinguish the phenotype from other ataxias seen in the RGTs. We collected DNA samples from 16 RGTs with signs of spinocerebellar ataxia beginning from 2-to-12 months of age, 640 control RGTs, and 383 dogs from 144 other breeds along with the medical records of affected dogs in order to elucidate the genetic cause of this disease. Whole-genome sequencing was performed on one RGT with ataxia and myokymia. Unique, homozygous variants were identified in this dog by comparing its sequence to whole-genome sequences from 81 other canids. We found a missense mutation in the gene coding for the inward rectifying potassium channel Kir4.1 (KCNJ10:c.627C>G) that was significantly associated with the disease. Dogs homozygous for the mutant allele all showed spinocerebellar ataxia with varying combinations of myokymia, seizures and other signs. The identification of a mutation in KCNJ10 in dogs with spinocerebellar ataxia with myokymia and/or seizures (SAMS) clarifies the multiple forms of ataxia seen in these breeds and provides a DNA test to identify carriers. Understanding the role the Kir4.1 channel plays in extracellular potassium buffering by astrocytes could shed light on other conditions characterized… Advisors/Committee Members: Johnson, Gary S., 1943- (advisor).

Subjects/Keywords: Dogs – Diseases – Genetic aspects; Diseases – Animal models

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APA (6^th Edition):

Gilliam, Douglas H., Jr., 1. (2016). Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/56525

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gilliam, Douglas H., Jr., 1983-. “Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.” 2016. Thesis, University of Missouri – Columbia. Accessed April 10, 2021. https://doi.org/10.32469/10355/56525.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gilliam, Douglas H., Jr., 1983-. “Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.” 2016. Web. 10 Apr 2021.

Vancouver:

Gilliam, Douglas H., Jr. 1. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2021 Apr 10]. Available from: https://doi.org/10.32469/10355/56525.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gilliam, Douglas H., Jr. 1. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. [Thesis]. University of Missouri – Columbia; 2016. Available from: https://doi.org/10.32469/10355/56525

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

29. Siame, Anthony Bupe. Analysis of the mycotoxins of fusarium .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1716

► Fusarium contamination of maize has been shown to be a problem in Zambia. In this study it was decided to test for the presence of… (more)

▼ Fusarium contamination of maize has been shown to be a problem in Zambia. In this study it was decided to test for the presence of five toxins produced by Fusarium; Zearalenone, T-2 toxin, diacetoxyscirpenol (DAS), deoxynivalenol (DON) and nivalenol, in maize and maize products. This was the first major study involving the analysis of trichothecenes in Zambia, and thus several methods of extraction and determination of the fo,ur tricho-thenes and Zearalenone in maize and mixed feeds were tested, in order to arrive at the most suitable methods for use in our Laboratory. The methods finally adopted gave 80, 80,86, 50 and 60 per cent recoveries of added Zearalenone, DON, nivalenol, T-2 toxin and DAS respectively. TLC was used for qualitative as well as quantitative determination of the toxins and as low as 50 (jg/kg Zearalenone, 80 |jg/kg DON and nivalenol, and about 2000 pg/kg T-2 toxin and DAS could be determined. Mouldy maize, rejected by NAMBOARD but mostly used by farmers as animal feed supplement or in the brewing of local opaque beer, was collected from farmers around Lusaka and analysed for the five Fusarium toxins. This maize was found to contain only Zearalenone and DON in the range of 0.08-6.0 mg/kg and 0.5-16 mg/kg respectively. A year long survey of mixed animal feeds from National Milling Company was initiated and 148 samples were analysed for Zearalenone, DON and nivalenol. 17 per cent of the samp¬les contained Zearalenone (0.05-0.6 mg/kg) and 1.4 per cent of the samples contained DON (1.0 mg/kg). No nivalenol was detected in any of the samples. The Zearalenone and DON positive samples were further tested for T-2 toxin and DAS but none was detected. This is the first report of the natural occurrence of Zearalenone and DON in mixed feed samples in Zambia. An isolate of F. graminearum was gro.wn at 26 C and 16°C corresponding to average maximum and minimum temperatures often recorded near the end of the rainy season. Zearalenone production was found to be favoured by low temperatures (16 C) while DON production was found to be favoured by high temperatures (26 C ).

Subjects/Keywords: Fusarium; Corn(diseases)

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APA (6^th Edition):

Siame, A. B. (2012). Analysis of the mycotoxins of fusarium . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siame, Anthony Bupe. “Analysis of the mycotoxins of fusarium .” 2012. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/1716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siame, Anthony Bupe. “Analysis of the mycotoxins of fusarium .” 2012. Web. 10 Apr 2021.

Vancouver:

Siame AB. Analysis of the mycotoxins of fusarium . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/1716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siame AB. Analysis of the mycotoxins of fusarium . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

30. Ahmadu, Babagana. Management practices, morphometric body measurements and diseases of local Zambian goats .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1774

► The management practices, morphometric body measurements and disease profiles of local Zambian goats were studied with the main objectives of assessing the existing production system.… (more)

Subjects/Keywords: Goats – Diseases – Zambia

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APA (6^th Edition):

Ahmadu, B. (2012). Management practices, morphometric body measurements and diseases of local Zambian goats . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1774

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ahmadu, Babagana. “Management practices, morphometric body measurements and diseases of local Zambian goats .” 2012. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/1774.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ahmadu, Babagana. “Management practices, morphometric body measurements and diseases of local Zambian goats .” 2012. Web. 10 Apr 2021.

Vancouver:

Ahmadu B. Management practices, morphometric body measurements and diseases of local Zambian goats . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/1774.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ahmadu B. Management practices, morphometric body measurements and diseases of local Zambian goats . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1774

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations