subject:(Diseases)

University of Zambia

1. Kampamba, Kelvin Mulenga. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

► Tungiasis, also commonly known as jiggers, is a zoonotic ectoparasitosis caused by the permanent penetration of the epidermis by a gravid female sand flea Tunga… (more)

▼ Tungiasis, also commonly known as jiggers, is a zoonotic ectoparasitosis caused by the permanent penetration of the epidermis by a gravid female sand flea Tunga penetrans in the skin of a host. The skin disease is known to occur throughout Latin America, the Caribbean and sub Saharan Africa especially among resource poor communities. There is no or little epidemiologic data on the skin disease in Zambia. A cross-section study was conducted in rural communities in Chipata and Vubwi districts of Zambia to determine the prevalence, risk factors and levels of awareness of tungiasis. A total of 384 households were visited from where at least one member was interviewed and examined. A household was considered infested if at least one individual had tungiasis. Collected data included among others social demographic characteristics, household living conditions, localization of the lesions, nature of lesions (avital or vital), number of embedded female T. penetrans and tungiasis specific disease related information including knowledge. The overall prevalence of active tungiasis in the study area was 13.5% (95% CI= 10.1 – 16.9) with Chipata recording 12.6% (95% CI= 8.5 – 16.7) and Vubwi 15.3% (95% CI= 9.3 – 21.3). On assessment of risk factors, individuals in age categories ≤ 15years and those ≥ 60 years showed higher prevalence 68.8% (95% CI= 46.1 – 91.5) and 18.2% (95% CI=2.1 – 34.3), respectively, compared to those in the intermediary age groups (p=0.001). The type of sanitary facilities and marital status as it related to age were found to be significant predictors of tungiasis (p<0.05). Living in a households with a pit latrines reduced the risk of tungiasis by 25.4% (95% CI= 0.071 – 0.913), when compared to those that practiced open defecation (p=0.036). Those that were of marriageable age and single (>20 years old and single) were 19.7 (95% CI= 5.152 – 75.469) more likely to have tungiasis than those that were married and ≥20 years old (p=0.001). All other variables were not significantly associated with T. penetrans (p>0.05). The levels of awareness of the disease in the study area were very good, ranging from 80% to 83% on the basis of having experienced tungiasis and 3.3% to 71% on disease specific knowledge. Tungiasis is prevalent among the studied rural communities in Chipata and Vubwi districts. Although the awareness of the disease was high in the studied communities, people were not able to link tungiasis with risk factors. More research work needs to be done in order to rank the risk factors and to determine the burden tungiasis exerts in economic terms.

Subjects/Keywords: Skin – Diseases; Foot – Diseases

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APA (6^th Edition):

Kampamba, K. M. (2015). Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kampamba, Kelvin Mulenga. “Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .” 2015. Thesis, University of Zambia. Accessed February 18, 2020. http://dspace.unza.zm:8080/xmlui/handle/123456789/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kampamba, Kelvin Mulenga. “Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia .” 2015. Web. 18 Feb 2020.

Vancouver:

Kampamba KM. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . [Internet] [Thesis]. University of Zambia; 2015. [cited 2020 Feb 18]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kampamba KM. Prevalence and associated risk factors of tungiasis in Chipata and Vubwi districts of eastern Zambia . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Chavwanga, Vytalis. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.

Degree: 2014, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/3215

► The study examines the role of the Department of Veterinary Services in controlling and preventing contagious cattle diseases in Zambia from 1907 to 1990. The… (more)

Subjects/Keywords: Cattle Diseases; Domestic Animals-Diseases

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APA (6^th Edition):

Chavwanga, V. (2014). The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chavwanga, Vytalis. “The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.” 2014. Thesis, University of Zimbabwe. Accessed February 18, 2020. http://dspace.unza.zm/handle/123456789/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chavwanga, Vytalis. “The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990.” 2014. Web. 18 Feb 2020.

Vancouver:

Chavwanga V. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2020 Feb 18]. Available from: http://dspace.unza.zm/handle/123456789/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chavwanga V. The Department of Veterinary Services and Control of contagious Cattle Diseases in Zambia,1907-1990. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

3. Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. Combined Disorders of Heart and Kidney : Heart and Kidney Link.

Degree: Department of Biology, 2016, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,2379

►

It is now clear that renal dysfunction is linked frequently with all types of heart failure (HF), and its development is associated with higher death… (more)

▼

It is now clear that renal dysfunction is linked frequently with all types of heart failure (HF), and its development is associated with higher death rates and morbidity. There is not any approved definition for the cardiorenal syndrome (CRS), but in general, CRS can be defined as a pathophysiologic disorder of both heart and kidneys in which acute or chronic dysfunction of one organ may cause acute or chronic dysfunction of the other. The aim of this thesis is to discuss the pathophysiology and clinical features of the link between heart disorders and kidney disorders in light of the actual clinical and experimental evidence. Because of the complex interdependent relationship, changes in heart and the kidney systems have been difficult to describe. Thus, CRS has been subdivided into five syndromes which include Type 1 CRS which is an acute cardiac event precipitating acute kidney injury (AKI); Type 2 CRS which is defined as a developing and permanent chronic kidney dysfunction which is induced by long-term cardiac dysfunction, for example, chronic congestive heart failure; Type 3 CRS which is described as an acute cardiac dysfunction and it is caused by a sudden renal dysfunction; Type 4 CRS which is defined as one in which chronic kidney diseases cause a worsening of cardiac function, cardiac hypertrophy, and/or progressive risk of adverse cardiovascular events; Type 5 CRS which is concomitant cardiac and renal dysfunctions due to systemic conditions that affect both organs, for example, diabetes mellitus and sepsis. In patients with severe sepsis, acute cardiovascular and renal dysfunction are common. Cardiorenal syndromes' pathophysiology includes endothelial dysfunction, alteration of myocardial function, reduced renal perfusion and venous congestion. Therefore, there should be preventive and diagnostic strategies that can preserve renal function and heart output in patients with kidney and/or HF.

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biological Sciences."; Thesis advisor: Ruth Rollin.; M.S.,Central Connecticut State University,,2016.;

Advisors/Committee Members: Rollin, Ruth.

Subjects/Keywords: Heart – Diseases.; Kidneys – Diseases.

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APA (6^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1. (2016). Combined Disorders of Heart and Kidney : Heart and Kidney Link. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. “Combined Disorders of Heart and Kidney : Heart and Kidney Link.” 2016. Thesis, Central Connecticut State University. Accessed February 18, 2020. http://content.library.ccsu.edu/u?/ccsutheses,2379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alrifai, Walaa A. (Walaa Abdulalrhman), 1989-. “Combined Disorders of Heart and Kidney : Heart and Kidney Link.” 2016. Web. 18 Feb 2020.

Vancouver:

Alrifai, Walaa A. (Walaa Abdulalrhman) 1. Combined Disorders of Heart and Kidney : Heart and Kidney Link. [Internet] [Thesis]. Central Connecticut State University; 2016. [cited 2020 Feb 18]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alrifai, Walaa A. (Walaa Abdulalrhman) 1. Combined Disorders of Heart and Kidney : Heart and Kidney Link. [Thesis]. Central Connecticut State University; 2016. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

4. Ramtahal, Melissa Afton. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.

Degree: M.Med., Infectious diseases, 2011, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/6294

► Mycobacterium tuberculosis (MTB) is an airborne pathogen that is easily transmitted from person to person. An intact immune system prevents the organism from causing disease… (more)

Subjects/Keywords: Infectious diseases.

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APA (6^th Edition):

Ramtahal, M. A. (2011). Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. (Masters Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/6294

Chicago Manual of Style (16^th Edition):

Ramtahal, Melissa Afton. “Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.” 2011. Masters Thesis, University of KwaZulu-Natal. Accessed February 18, 2020. http://hdl.handle.net/10413/6294.

MLA Handbook (7^th Edition):

Ramtahal, Melissa Afton. “Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal.” 2011. Web. 18 Feb 2020.

Vancouver:

Ramtahal MA. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. [Internet] [Masters thesis]. University of KwaZulu-Natal; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10413/6294.

Council of Science Editors:

Ramtahal MA. Spread of multi drug resistant tuberculosis (MDR) including extensively drug resistant turberculosis (XDR TB), in rural KwaZulu-Natal. [Masters Thesis]. University of KwaZulu-Natal; 2011. Available from: http://hdl.handle.net/10413/6294

University of KwaZulu-Natal

5. Kharsany, Ayesha Bibi Mahomed. Microbiology of vaginal discharge with emphasis on gardnerella vaginalis.

Degree: M. Med. Sci., 2014, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/10890

► The microbiological aetiology of vaginal discharge was studied in 208 women attending various outpatient clinics at King Edward VIII Hospital. Specimens from the lower genital… (more)

▼ The microbiological aetiology of vaginal discharge was studied in 208 women attending various outpatient clinics at King Edward VIII Hospital. Specimens from the lower genital tract were collected for microscopy and culture. Vaginal wet smear examination, amine liberation test and vaginal pH estimation were performed and assessed for their reliability for the rapid diagnosis of vaginal infections. Vaginal and endo-cervical infections were present in 163 (78,4%) women. Q. vaginalis (65,4%), I. vaginalis (37,9%), genital yeasts (37,0%), ~. hominis (59,6%), g. urealyticum (48,1%), anaerobic bacteria (32,6%), ~. gonorrhoeae (11,1%), f. trachomatis (22,1%) and Herpes simplex virus (0,9%) were detected. Of the 104 women in • whom vaginal infections were detected, bacterial vaginosis was present as the sole infection in 32 (22,2%), I. vaginalis in 35 (24,3%) and C. albicans in 23 (15,9%). Bacterial vaginosis occurred concurrently with I. vaginalis and f. albicans in 24 (16,5%) and 11 (7,5%) women respectively; whilst I. vaginalis and f. albicans occurred concurrently in 14 (9,7%) women. In 6 (4,1%) women all three infections were present. No vaginal or endo-cervical pathogens were detected in 45 (21,6%) women. Women with bacterial vaginosis were found to be significantly colonised with G. vaginalis, M, hominis, anaerobic bacteria and curved Gram-negative bacilli (p < 0,05). Vaginal wet smear microscopy detected T. vaginalis in 29% and "clue" cells in 41,3% of smears. The presence of "clue" cells (91,8%) and a positive amine test (76,7%) was significantly associated with bacterial vaginosis. Although a raised vaginal pH was also significantly associated with bacterial vaginosis, this test was less specific (65,2%) than "clue" cells (85,9%) and the amine test (95,5%). The vaginal Gram stain, as performed in this study, was found to be unreliable for the detection of "clue" cells. G. vaginalis biotypes 1 and 5 were significantly associated with bacterial vaginosis, however the serotyping scheme did not distinguish between strains isolated from women with and without bacterial vaginosis. The antimicrobial susceptibility pattern of 93 strains of G. vaginalis was not typical of either Gram-positive or Gram-negative bacteria. Serological tests revealed reactive syphilis serology in 47 (22,6%) and the presence of hepatitis B surface antigen in 16 (7,7%) women. Antibody to human immunodeficiency virus was detected in 4 (1,9%) women attending the colposcopy clinic. This study clearly demonstrates the high prevalence of vaginal and/or endo-cervical infections in women locally, the majority of whom were asymptomatic. The high frequency of concurrent infections is of concern and there is a need for the recognition, and appropriate management of such infections. Advisors/Committee Members: Van den Ende, Jan (advisor), Moodley, J (advisor).

Subjects/Keywords: Vagina – Diseases.

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APA (6^th Edition):

Kharsany, A. B. M. (2014). Microbiology of vaginal discharge with emphasis on gardnerella vaginalis. (Masters Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/10890

Chicago Manual of Style (16^th Edition):

Kharsany, Ayesha Bibi Mahomed. “Microbiology of vaginal discharge with emphasis on gardnerella vaginalis.” 2014. Masters Thesis, University of KwaZulu-Natal. Accessed February 18, 2020. http://hdl.handle.net/10413/10890.

MLA Handbook (7^th Edition):

Kharsany, Ayesha Bibi Mahomed. “Microbiology of vaginal discharge with emphasis on gardnerella vaginalis.” 2014. Web. 18 Feb 2020.

Vancouver:

Kharsany ABM. Microbiology of vaginal discharge with emphasis on gardnerella vaginalis. [Internet] [Masters thesis]. University of KwaZulu-Natal; 2014. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10413/10890.

Council of Science Editors:

Kharsany ABM. Microbiology of vaginal discharge with emphasis on gardnerella vaginalis. [Masters Thesis]. University of KwaZulu-Natal; 2014. Available from: http://hdl.handle.net/10413/10890

University of Hong Kong

6. Kwong, Shu-keung. Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study.

Degree: Master of Medical Sciences, 2017, University of Hong Kong

URL: http://hdl.handle.net/10722/251320

►

Objectives To study cytohistologic changes from women with HPV DNA tests positive. Materials and Methods: From July 2007 to Jan 2017, the archival files of… (more)

▼

Objectives To study cytohistologic changes from women with HPV DNA tests positive. Materials and Methods: From July 2007 to Jan 2017, the archival files of CH Pathology, limited (from July 2007 to August 2015) and [email protected] (from August 2015 onward), which includes the files of all cases with HPV positive, were reviewed for follow up study. Total cases which HPV DNA genotyping test were positive were reviewed. Cytologic or histopathologic results were found out to analysis. IBM SPSS statistics (International Business Machines Corporation Statistical Product and Service Solutions) was the tool for data treatment, using Pearson’s X2 test and continuity correction test (Yates corrected X2 test) (For n ≥ 40, 1≤ E <5), Fisher’s exact probability test (For n < 40 or E <1). All p values were two - sided, and p ≤ 0.05 was defined as statistic significant. Results A total of 1335 cases of women with HPV positive, aged 15 to 81 years were analyzed, including 865 (64.8%) cases with high-risk HPV positive only, 290 (21.9%) patients with low-risk HPV positive only, 180 (13.5%) cases with both high-risk and low-risk HPV positive. In descending order, the most common three high-risk HPV genotypes were HPV type 52 (19.7%), HPV type 16 (12.0%) and HPV type 58 (%); the most common three low-risk HPVs were HPV type 54 (12.3%), HPV type 42 (10.1%) and HPV type 6 (%). High-risk HPV positive only were associated with ASC-US (p = 0.000004), LSIL (p = 0.012), HSIL (p = 0.050). Low-risk HPV positive only were associated with ASC-US (p = 0.000001), ASC-H (p = 0.005). ASC-US was associated with HPV type 33 (p = 0.0013), HPV type 40 (p = 0.003) and HPV type 42 (p = 0.0033). LSIL was associated with HPV type 53 (p < 0.00001), HPV type 56 (p< 0.00001), HPV type 59 (p = 0.0035), HPV type 66 (p < 0.00001), HPV type 40 (p = 0.024), HPV type 42 (p = 0.003). HSIL was associated with HPV type 16 (p=0.000013) and HPV type 52 (p=0.013). CIN I was associated with HPV type 59 (p = 0.002). CIN II was associated with HPV type 16 (p = 0.003). Conclusions In descending order, the most common three genotypes of high-risk HPV infection are HPV type 52, 16 and 58; the most common three genotypes of low-risk HPV infection are HPV type 54, 42 and 6. The majority abnormalities of cytologic change after HPV infection are ASC-US and LSIL. High-risk HPV is associated with HSIL. HPV type 59 is associated with CIN I, HPV type 16 is associated with CIN II.

published_or_final_version

Pathology

Master

Master of Medical Sciences

Subjects/Keywords: Papillomavirus diseases

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APA (6^th Edition):

Kwong, S. (2017). Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study. (Masters Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/251320

Chicago Manual of Style (16^th Edition):

Kwong, Shu-keung. “Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study.” 2017. Masters Thesis, University of Hong Kong. Accessed February 18, 2020. http://hdl.handle.net/10722/251320.

MLA Handbook (7^th Edition):

Kwong, Shu-keung. “Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study.” 2017. Web. 18 Feb 2020.

Vancouver:

Kwong S. Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study. [Internet] [Masters thesis]. University of Hong Kong; 2017. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10722/251320.

Council of Science Editors:

Kwong S. Cytohistologic changes in women positive for human papillomavirus DNA : a follow up study. [Masters Thesis]. University of Hong Kong; 2017. Available from: http://hdl.handle.net/10722/251320

University of Tasmania

7. Au, BT. Reliability and validity of physical activity measurements in Vietnam.

Degree: 2010, University of Tasmania

URL: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

► Mortality from non-communicable diseases (NCD) has increased in Vietnam in recent decades. Relatively little is known about the prevalence of risk factors for NCD in… (more)

▼ Mortality from non-communicable diseases (NCD) has increased in Vietnam in recent decades. Relatively little is known about the prevalence of risk factors for NCD in Vietnam, particularly for rural populations living outside the two major cities of Ha Noi and Ho Chi Minh City. The measurement of physical inactivity, an established risk factor for disease in Western populations, has not been attempted. The principal aim of this thesis was to test the reliability and validity of several methods of measuring physical activity in the Vietnamese population. A secondary aim was to investigate the prevalence of physical inactivity and other NCD risk factors in a population-based sample of rural Vietnam. A population survey (n=1978) was conducted in 2005 in Can Tho in the Mekong Delta of southern Vietnam, using the STEPS methodology developed by the World Health Organisation. Measurements of physical activity were made using the Global Physical Activity Questionnaire (GPAQ). GPAQ is a modified version of the International Physical Activity Questionnaire (IPAQ). A sub-sample (n=251) of participants had multiple measurements of physical activity using GPAQ, IPAQ, pedometers, and physical activity records (PAR). The key findings were: 1. The prevalence of NCD risk factors in the dominantly rural sample were very different from those previously reported for big city samples from Ha Noi and Ho Chi Minh City. 2. Work activity constituted 80% of total moderate and vigorous activity, and 33% of men and 40% of women were classified as inactive. 3. The modifications of IPAQ in the design of GPAQ have improved the physical activity estimates for those with stable work patterns, but, overall, both questionnaires had modest reliability and validity in estimating physical activity. 4. It was feasible to obtain a superior estimate of physical activity using at least three days of pedometer wear. 5. The use of pedometers was culturally acceptable to the local population. The involvement of health volunteers was critical, but they require constant supervision. 6. Tobacco smoking, a potential confounder of the association between physical activity and NCD risk indicators, was associated with hypertension in a doseresponse fashion. 7. Physical activity measured by GPAQ was associated with total cholesterol and, for men, with body composition and blood glucose. Work activity was the main contributor to these associations. For Vietnam, the GPAQ modifications of IPAQ have been only partly successful. Objective measurement by pedometers is feasible and culturally acceptable, and should be encouraged.

Subjects/Keywords: Exercise; Diseases

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APA (6^th Edition):

Au, B. (2010). Reliability and validity of physical activity measurements in Vietnam. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Au, BT. “Reliability and validity of physical activity measurements in Vietnam.” 2010. Thesis, University of Tasmania. Accessed February 18, 2020. https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Au, BT. “Reliability and validity of physical activity measurements in Vietnam.” 2010. Web. 18 Feb 2020.

Vancouver:

Au B. Reliability and validity of physical activity measurements in Vietnam. [Internet] [Thesis]. University of Tasmania; 2010. [cited 2020 Feb 18]. Available from: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Au B. Reliability and validity of physical activity measurements in Vietnam. [Thesis]. University of Tasmania; 2010. Available from: https://eprints.utas.edu.au/19315/7/whole_Thay_Au_ex_pub_mat_thesis.pdf ; https://eprints.utas.edu.au/19315/1/whole_AuBichThuy2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan Technological University

8. Huber, Mike. SALT SENSITIVE HYPERTENSION AND OREXIN.

Degree: MS, Department of Biological Sciences, 2016, Michigan Technological University

URL: http://digitalcommons.mtu.edu/etdr/267

► Elevated plasma arginine vasopressin (AVP) levels have been found in human hypertension subjects and several salt dependent experimental animal models of hypertension including the… (more)

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Huber, M. (2016). SALT SENSITIVE HYPERTENSION AND OREXIN. (Masters Thesis). Michigan Technological University. Retrieved from http://digitalcommons.mtu.edu/etdr/267

Chicago Manual of Style (16^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Masters Thesis, Michigan Technological University. Accessed February 18, 2020. http://digitalcommons.mtu.edu/etdr/267.

MLA Handbook (7^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Web. 18 Feb 2020.

Vancouver:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Internet] [Masters thesis]. Michigan Technological University; 2016. [cited 2020 Feb 18]. Available from: http://digitalcommons.mtu.edu/etdr/267.

Council of Science Editors:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Masters Thesis]. Michigan Technological University; 2016. Available from: http://digitalcommons.mtu.edu/etdr/267

9. Jones, Geraldine Brown. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.

Degree: 2015, Texas Woman's University

URL: http://hdl.handle.net/11274/7047

► The purpose of this hermeneutic phenomenological study was to explore elderly patients perspectives regarding discharge instructions related to self-management of their chronic illnesses once they… (more)

▼ The purpose of this hermeneutic phenomenological study was to explore elderly patients perspectives regarding discharge instructions related to self-management of their chronic illnesses once they were discharged from the hospital to their home. The combination of the growing elderly population, inadequate health literacy, and the prevalence of comorbidity illustrate the complex needs of this population of patient in regards to self-management of chronic illnesses once discharged (National Research Council of the National Academies, 2012). Study participants were recruited from two cardiovascular hospital-based clinics located in a large medical center in Texas. A purposive sampling was used to secure a sample of 20 participants meeting the following inclusion criteria: older than 65 years of age, diagnosis of any type of cardiovascular disease, cognitive competence, length of stay in the hospital greater than 3 days, discharged home rather than to long term care facility or nursing home, first follow-up doctor visit 2-4 weeks after discharge from the hospital and English speaking. </DISS_para> <DISS_para>Data were collected using a demographic questionnaire, a cognitive screening test (Mini Cog) and semi-structured audio-recorded interviews that lasted approximately 30-45 minutes. Trustworthiness was established using Lincoln and Guba s framework (1985) to secure credibility, transferability, dependability, and confirmability. Analysis was conducted using the Lindseth and Norberg s (2004) hermeneutical interpretation method which includes three steps: naïve reading, structural analysis and comprehensive understanding. A major finding was that patients perceptions of their discharge instructions did not match the reality of their post-discharge needs. Four themes emerged, reflecting aspects about transition from hospital to home: Just-in-time Discharge Process, I Thought the Instructions Were Good, But , What Would I do Without My Caregiver, and It Would Help If I Had This study identified gaps in discharge instructions and the degree to which they did or failed to prepare elderly patients to self-manage their chronic illness once discharged home. Such gaps potentially result in poor self-management and subsequent rehospitalization. Without strengthening the hospital discharge instruction process, self-management of illness in the elderly patient population will continue to be a major challenge. Advisors/Committee Members: Young, Anne (advisor), Symes, Lene (advisor), Cesareo, Sandra (advisor).

Subjects/Keywords: Chronic diseases

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APA (6^th Edition):

Jones, G. B. (2015). Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. (Thesis). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Geraldine Brown. “Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.” 2015. Thesis, Texas Woman's University. Accessed February 18, 2020. http://hdl.handle.net/11274/7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Geraldine Brown. “Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home.” 2015. Web. 18 Feb 2020.

Vancouver:

Jones GB. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. [Internet] [Thesis]. Texas Woman's University; 2015. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/11274/7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones GB. Older persons' experiences of hospital patient education and self-management of their chronic diseases once discharged home. [Thesis]. Texas Woman's University; 2015. Available from: http://hdl.handle.net/11274/7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – East Bay

10. Lau, Henry Ka Chang. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.

Degree: 2013, California State University – East Bay

URL: http://hdl.handle.net/10211.3/98350

► It is difficult to isolate target bacteria in high background microbiota food matrices. This is certainly the case for isolating Shigellae from foods such as… (more)

▼ It is difficult to isolate target bacteria in high background microbiota food matrices. This is certainly the case for isolating Shigellae from foods such as apple juice, potato salad, bagged peeled carrots, whole romaine lettuce, alfalfa sprouts, and green onions. A comparison of current methods was performed using USFDA Bacterial Analytical Method (BAM), USFDA 2009 modified Produce Assignment, Pathatrix IMS, and KingFisher Flex. Using the results from the comparisons, a novel streamlined method named Pathatrix-KingFisher was created for detecting and isolating Shigellae in green onions. The Immunomagnetic Separation (IMS) technology used by Pathatrix Auto and KingFisher Flex instruments aided in screening and recovery of Shigellae. Furthermore, a direct comparison of the USFDA 2009 modified Produce Assignment with my novel Pathatrix-KingFisher method on green onions was performed. Food samples were artificially inoculated with < 30 CFU/25 g of a previously -80??C frozen Shigella flexneri 2457M culture, and compared with no-spike controls and no-matrix controls. All methods were evaluated at 5 h and/or 24 h post-incubation for their detection and isolation efficacy. Presumptive positive isolates were confirmed to be Shigellae using TSI slants and/or qPCR with primers to the Shigellae specific ipaH gene. The USFDA BAM method was able to detect and recover Shigellae on processed foods (for example, apple juice, potato salad, bagged peeled carrots, whole romaine lettuce), but not for food with high background microbiota (for example, alfalfa sprouts and green onions). The USFDA 2009 modified Produce Assignment method was inconsistent at detecting and isolating Shigellae from all foods. The Pathatrix IMS method was effective at detecting Shigellae in foods, but was ineffective at isolating Shigellae. Both the Pathatrix IMS and KingFisher Flex were able to detect Shigellae using qPCR consistently after 5 h of incubation. The recoveries at 5 h incubation, even with the help of IMS from the two instruments, were inconsistent. Shigellae were detected and isolated regularly after 24 h of incubation using the KingFisher Flex. When compared to the USFDA 2009 modified Produce Assignment method, both the IMS methods were more consistent in detecting and isolating Shigellae in green onions. By using both instruments, my novel method, Pathatrix-KingFisher, takes advantage of the sensitivity of Pathatrix Auto sample size and the automation of the KingFisher Flex???s 96- well format to generate consistent high-throughput results. Two automated platforms using immunomagnetic separation technology were compared for detecting and recovering Escherichia coli O157 in ground beef and sprouts and Shigella flexneri in green onions. The foods were inoculated with < 20 CFU/25 g and tested at 5 and 24 h post-incubation. Immunomagnetic beads were mixed with food enrichments, processed through the Pathatrix Auto or KingFisher Flex, and tested by realtime PCR (qPCR) and recovery on selective agars. At 5 h, the… Advisors/Committee Members: Baysdorfer, Dr. Christoph W. (advisor), Lauzon, Dr. Carol R. (primaryAdvisor).

Subjects/Keywords: Foodborne diseases

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APA (6^th Edition):

Lau, H. K. C. (2013). The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. (Thesis). California State University – East Bay. Retrieved from http://hdl.handle.net/10211.3/98350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Henry Ka Chang. “The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.” 2013. Thesis, California State University – East Bay. Accessed February 18, 2020. http://hdl.handle.net/10211.3/98350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Henry Ka Chang. “The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation.” 2013. Web. 18 Feb 2020.

Vancouver:

Lau HKC. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. [Internet] [Thesis]. California State University – East Bay; 2013. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10211.3/98350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau HKC. The Detection and Isolation of Shigella spp. in Foods by Immunomagnetic Separation. [Thesis]. California State University – East Bay; 2013. Available from: http://hdl.handle.net/10211.3/98350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

11. Narayanappa, Murugesh. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.

Degree: PhD, Biochemistry and Biophysics, 2016, Oregon State University

URL: http://hdl.handle.net/1957/60041

► Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after… (more)

▼ Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost society an average of 300,000 dollars over the lifetime of a person. It also has serious impacts on quality of life including the literacy rate in children. Although, hearing loss is clearly a major health problem its genetic basis for the pathology is poorly understood. To date, over 60 pathogenic mutations in otoferlin have been found to be associated with inherited, non-syndromic congenital hearing loss and temperature sensitive auditory neuropathy (TSAN). The sense of hearing depends on reliable and temporally precise neurotransmitter release at the synapses of inner hair cells (IHCs) of the cochlea. Inner hair cells of the cochlea derive their name from hair bundle (stereocilia) protruding at the apical tip of the cell, that are arranged in rows of graded height. The nanometer displacement of the hair bundle opens mechanically gated ion channels that depolarize the cell. This change in membrane potential triggers calcium dependent fusion of synaptic vesicles with the plasma membrane and the release of neurotransmitter. In IHCs, Calcium-regulated exocytosis and neurotransmitter release exhibit fast kinetics in achieving exquisite temporal fidelity. To aid in fidelity and for allowing high rates of sustained synaptic neurotransmission, IHCs contain specialized structures called synaptic ribbons for tethering synaptic vesicles at release sites. The calcium triggered synaptic vesicle fusion with the plasma membrane is believed to be driven by the assembly of SNARE proteins. However, SNARE proteins are insensitive to calcium. In conventional neurotransmission in neurons, synaptotagmin 1 confers calcium sensitivity to SNARE-mediated fast synchronous neurotransmission. However, Yasunaga et al. 1999 and Beurg et al. 2010 have reported that synaptotagmin 1 was not detected in mature IHCs and it has been suggested that IHCs have evolved a unique calcium sensor, otoferlin for calcium-regulated synaptic neurotransmission. The evidence for calcium sensor hypothesis of otoferlin comes from Roux et al., 2006 who reported that mice lacking otoferlin were profoundly deaf and lack synaptic vesicle exocytosis in IHCs. Otoferlin has also been shown to be required for calcium dependent synaptic exocytosis at immature outer hair cells (OHCs) and vestibular hair cells. Otoferlin belongs to ferlin family of proteins and consists of six C2 domains (C2A- C2F) linked in tandem followed by a single-pass C-terminal transmembrane region. C2 domains are known to bind to calcium and lipids. The lipid and calcium binding properties of synaptic proteins are critical characteristics that define and shape the release properties of a synapse, and thus, without a quantitative characterization of these activities, an understanding of… Advisors/Committee Members: Johnson, Colin (advisor), Weihong, Qiu (committee member).

Subjects/Keywords: Cochlea – Diseases

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APA (6^th Edition):

Narayanappa, M. (2016). Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/60041

Chicago Manual of Style (16^th Edition):

Narayanappa, Murugesh. “Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.” 2016. Doctoral Dissertation, Oregon State University. Accessed February 18, 2020. http://hdl.handle.net/1957/60041.

MLA Handbook (7^th Edition):

Narayanappa, Murugesh. “Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea.” 2016. Web. 18 Feb 2020.

Vancouver:

Narayanappa M. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. [Internet] [Doctoral dissertation]. Oregon State University; 2016. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/1957/60041.

Council of Science Editors:

Narayanappa M. Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea. [Doctoral Dissertation]. Oregon State University; 2016. Available from: http://hdl.handle.net/1957/60041

12. Duff, Jed. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.

Degree: PhD, 2013, Australian Catholic University

URL: https://researchbank.acu.edu.au/theses/448

► Venous thromboembolism (VTE) is the umbrella term covering deep vein thrombosis, pulmonary embolism and a group of associated chronic conditions. This vascular disease process is… (more)

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Duff, J. (2013). Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. (Doctoral Dissertation). Australian Catholic University. Retrieved from https://researchbank.acu.edu.au/theses/448

Chicago Manual of Style (16^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Doctoral Dissertation, Australian Catholic University. Accessed February 18, 2020. https://researchbank.acu.edu.au/theses/448.

MLA Handbook (7^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Web. 18 Feb 2020.

Vancouver:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Internet] [Doctoral dissertation]. Australian Catholic University; 2013. [cited 2020 Feb 18]. Available from: https://researchbank.acu.edu.au/theses/448.

Council of Science Editors:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Doctoral Dissertation]. Australian Catholic University; 2013. Available from: https://researchbank.acu.edu.au/theses/448

University of Cape Town

13. Tadokera, Rabecca. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.

Degree: Image, Institute of Infectious Disease and Molecular Medicine, 2011, University of Cape Town

URL: http://hdl.handle.net/11427/11589

► While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome… (more)

Subjects/Keywords: Infectious Diseases

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APA (6^th Edition):

Tadokera, R. (2011). Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/11589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tadokera, Rabecca. “Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.” 2011. Thesis, University of Cape Town. Accessed February 18, 2020. http://hdl.handle.net/11427/11589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tadokera, Rabecca. “Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome.” 2011. Web. 18 Feb 2020.

Vancouver:

Tadokera R. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/11427/11589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tadokera R. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/11589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Central Florida

14. Horton, Julie. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.

Degree: 2017, University of Central Florida

URL: https://stars.library.ucf.edu/etd/5697

► Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the… (more)

▼ Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the heart to adequately execute requisite pump function in order to deliver nutrients and oxygen to peripheral tissues, irrespective of etiology. One of the most common causes of HF is chronic pressure overload due to hypertension. Ischemic heart disease is also a common driver of HF, often in conjunction with hypertension. Pressure overload initially causes compensatory metabolic changes. Structural changes follow shortly thereafter typically resulting in left ventricular hypertrophy. Eventually, the heart loses the ability to compensate for the aberrant hemodynamic load and begins failing. The failing heart is unable to supply adequate adenosine triphosphate (ATP) for contractile function as evidenced by falling phosphocreatine (PCr) levels. This energy deficit occurs concurrently with a metabolic re-programming that results in a fuel utilization pattern resembling the fetal heart. Notably, enzymes involved in catabolism of fatty acids, the chief fuel substrate for ATP generation in the normal adult heart, are downregulated in the failing heart. However, the extent to which alternative fuels compensate for decreased fatty acid oxidation (FAO) is not well-known. Furthermore, consequences of the fuel substrate switches that occur in heart failure are not well established. In this work, we discover a new paradigm for alternate fuel utilization in the failing heart and define consequences of altered fuel metabolism in HF. We discovered a post-translational modification resultant from an accumulation of acetyl groups (C2) present in a mouse model of early-stage HF and human HF. Mitochondrial proteins were found to be hyperacetylated in the failing heart, and at least some of these alterations result in diminished electron-transport chain (ETC) capacity as shown by mutagenesis studies on succinate dehydrogenase A (SDHA). We also found an accumulation of C4-OH carnitine, a by-product of ketone oxidation in HF. This metabolite aggregation occurred alongside an increase in b-hydroxybutyrate dehydrogenase 1 (BDH1) transcript and protein levels. This signature suggested that the failing heart shifted to ketone bodies as a fuel. Subsequent experiments confirmed increased capacity for myocardial ketone oxidation in compensated cardiac hypertrophy and in HF. The consequences of increased ketone oxidation were then assessed using a cardiac-specific BDH1 knockout (BDH1 KO) mouse. Despite not having any apparent defect at baseline, we found BDH1 KO mouse hearts are completely unable to oxidize 3-hydroxybutyrate. The deficit for ketone oxidation capacity became consequential upon subjugation to transverse aortic constriction with a small apical myocardial infarction (TAC/MI). The BDH1 KO mice exhibit altered pathological cardiac remodeling compared to wild-type controls. These latter data suggest the increased reliance on ketone oxidation in HF, mediated by BDH1, is an adaptive… Advisors/Committee Members: Estevez, Alvaro.

Subjects/Keywords: Cardiovascular Diseases

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APA (6^th Edition):

Horton, J. (2017). Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. (Doctoral Dissertation). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/5697

Chicago Manual of Style (16^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Doctoral Dissertation, University of Central Florida. Accessed February 18, 2020. https://stars.library.ucf.edu/etd/5697.

MLA Handbook (7^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Web. 18 Feb 2020.

Vancouver:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Internet] [Doctoral dissertation]. University of Central Florida; 2017. [cited 2020 Feb 18]. Available from: https://stars.library.ucf.edu/etd/5697.

Council of Science Editors:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Doctoral Dissertation]. University of Central Florida; 2017. Available from: https://stars.library.ucf.edu/etd/5697

University of Hong Kong

15. 王可; Wang, Ke. Exploration of drug therapy in mouse models of human retinal diseases.

Degree: PhD, 2015, University of Hong Kong

URL: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

►

Retinitis pigmentosa (RP) is a series of inherited retinal degenerative diseases mostly caused by the gene mutations in rod photoreceptors, which lead to the primary… (more)

▼

Retinitis pigmentosa (RP) is a series of inherited retinal degenerative diseases mostly caused by the gene mutations in rod photoreceptors, which lead to the primary loss of rod photoreceptors, and the secondary loss of cone photoreceptors. More than 1.5 million people worldwide lose their sight every year as a result of RP disorder. RP is a hereditary disease with complex causes, there are currently no ideal treatments that are either against primary gene mutations or against the secondary neuronal degeneration. Therapies that aim to preserve photoreceptor function may represent an effective alternative for improving the quality of life of many RP patients. The main focus of this thesis was to investigate the pathological mechanism of RP and to explore possible therapeutic strategies for it. Although the mechanisms of photoreceptor death remain elusive in RP, multiple mechanisms are suggested to have a role in photoreceptor death. To confirm the involvement of multiple pathways in RP, we systemically applied three multi-target iron-chelator based compounds: VK28, M30, VAR10303and one multi-target traditional Chinese medicine LBP (Lycium barbarum polysaccharides)to the rd10 mouse model of RP. The effectiveness of these drugs was evaluated by morphological, electrophysiological, behavioral and molecular biological analysis. We found thatVK28, M30, VAR10303and LBP appeared to have both short-term and long-term neuroprotective effects on photoreceptor cell. We further identified that these compounds exerted their effects through anti-apoptotic, antioxidant and anti-inflammatory mechanisms. The findings provided more evidence on the involvement of multiple mechanisms in photoreceptor degeneration of RP, suggesting a multi-target drug therapy is more sufficient than a single-targeted manipulation in protecting photoreceptors from degeneration in RP treatment. Neuroinflammation is suggested to be involved in pathology of glaucoma, but the mechanisms regulating microglia activation are not yet clear. We thus investigated the mechanisms underlying microglia activation in a mouse model of glaucoma. We found that microglia activation played a pathogenic role in AOH-caused retinal ganglion cell (RGC).We also demonstrated that chemokine receptorCX3CR1 in microglia played an important role in regulating microglia activation. Our findings indicate that suppressing neuroinflammation might be a therapeutic option for improving RGC survival in patients with glaucoma.

published_or_final_version

Biomedical Sciences

Doctoral

Doctor of Philosophy

Subjects/Keywords: Retina - Diseases - Treatment; Retina - Diseases - Animal models

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APA (6^th Edition):

王可; Wang, K. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Doctoral Dissertation). University of Hong Kong. Retrieved from Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

Chicago Manual of Style (16^th Edition):

王可; Wang, Ke. “Exploration of drug therapy in mouse models of human retinal diseases.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed February 18, 2020. Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370.

MLA Handbook (7^th Edition):

王可; Wang, Ke. “Exploration of drug therapy in mouse models of human retinal diseases.” 2015. Web. 18 Feb 2020.

Vancouver:

王可; Wang K. Exploration of drug therapy in mouse models of human retinal diseases. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2020 Feb 18]. Available from: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370.

Council of Science Editors:

王可; Wang K. Exploration of drug therapy in mouse models of human retinal diseases. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Wang, K. [王可]. (2015). Exploration of drug therapy in mouse models of human retinal diseases. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5689280 ; http://dx.doi.org/10.5353/th_b5689280 ; http://hdl.handle.net/10722/222370

University of Hong Kong

16. 赵旵军; Zhao, Hanjun. A study of antiviral peptides with broad activity against respiratory viruses.

Degree: PhD, 2013, University of Hong Kong

URL: Zhao, H. [赵旵军]. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137969 ; http://dx.doi.org/10.5353/th_b5137969 ; http://hdl.handle.net/10722/205838

► A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging viral respiratory diseases such as avian influenza H5N1 and H7N9, severe acute respiratory… (more)

▼ A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging viral respiratory diseases such as avian influenza H5N1 and H7N9, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Previous studies carried out by PhD students in our lab found that mouse β-defenisn 4 (mBD4) shows highly antiviral activity in vitro. However, the recombinant mBD4 (rmBD4) expressed by E.coli is limited to very small scale of production and is very expensive. Thus, in this study, we firstly screened 16 short peptides derived from mBD4 and other mouse and human β-defensins for identifying their antiviral effects. One short peptide P9 (30 amino acids), derived from mBD4, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses, including influenza A viruses H1N1, H3N2, H5N1, H7N7 and H7N9, SARS coronavirus (SARS-CoV)and MERS coronavirus (MERS-CoV). This P9 showed very high selectivity index (970), which was higher than that of the full-length peptide of synthetic mBD4 (smBD4) and rmBD4 in vitro. Secondly, the prophylactic and therapeutic effects of P9 against the infection of H1N1 virus were further detected in animal model. The survival rate of P9-pretreated mice challenged by lethal dose of H1N1 virus was 100%. The therapeutic effects of P9 protecting mice from lethal challenge of H1N1 virus were also statistically significant. The survival rate of mice could reach up to 67% by intranasal inoculation and 56% by intraperitoneal injection, respectively. To investigate the antiviral mechanism, we firstly elucidated that P9 could inhibit viral infection but not viral replication or release. Secondly, we detected whether P9 inhibited viral infection by binding to the surface of target cells or viral particles. The results showed that P9 only bound to viral particles but not to the cell surface. It was further identified that P9 bound to viral surface glycoprotein HA but not NA. Thirdly, we demonstrated that P9 did not inhibit virus binding to its receptor and block the virus entry into cells by endocytosis. Instead, P9 inhibited the acidification in late endosomes and thusP9 blocked virus-membrane fusion and subsequent viral disassembly and viral RNA release. Finally, we elucidated that the antiviral activity of P9 was attributed to its high binding affinity to viral HA and the abundance of basic amino acids in its composition. In this study, we have demonstrated that a short peptide P9, which is derived from mBD4, showed potent antiviral activity against multiple respiratory viruses. This peptide can be developed to a new promising prophylactic and therapeutic agent with broad-spectrum antiviral activity and low possibility to cause drug resistance. Moreover, this study has also revealed a novel antiviral mechanism for P9 and paved a path for the development of new antiviral agents with broad-spectrum antiviral activity against emerging respiratory viruses, such as avian influenza H5N1 and H7N9, as well as SARS-CoV and…

Subjects/Keywords: Peptides; Respiratory organs - Diseases; Virus diseases

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APA (6^th Edition):

赵旵军; Zhao, H. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Doctoral Dissertation). University of Hong Kong. Retrieved from Zhao, H. [赵旵军]. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137969 ; http://dx.doi.org/10.5353/th_b5137969 ; http://hdl.handle.net/10722/205838

Chicago Manual of Style (16^th Edition):

赵旵军; Zhao, Hanjun. “A study of antiviral peptides with broad activity against respiratory viruses.” 2013. Doctoral Dissertation, University of Hong Kong. Accessed February 18, 2020. Zhao, H. [赵旵军]. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137969 ; http://dx.doi.org/10.5353/th_b5137969 ; http://hdl.handle.net/10722/205838.

MLA Handbook (7^th Edition):

赵旵军; Zhao, Hanjun. “A study of antiviral peptides with broad activity against respiratory viruses.” 2013. Web. 18 Feb 2020.

Vancouver:

赵旵军; Zhao H. A study of antiviral peptides with broad activity against respiratory viruses. [Internet] [Doctoral dissertation]. University of Hong Kong; 2013. [cited 2020 Feb 18]. Available from: Zhao, H. [赵旵军]. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137969 ; http://dx.doi.org/10.5353/th_b5137969 ; http://hdl.handle.net/10722/205838.

Council of Science Editors:

赵旵军; Zhao H. A study of antiviral peptides with broad activity against respiratory viruses. [Doctoral Dissertation]. University of Hong Kong; 2013. Available from: Zhao, H. [赵旵军]. (2013). A study of antiviral peptides with broad activity against respiratory viruses. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5137969 ; http://dx.doi.org/10.5353/th_b5137969 ; http://hdl.handle.net/10722/205838

University of Hong Kong

17. Chan, Koon-ho. Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders.

Degree: PhD, 2012, University of Hong Kong

URL: Chan, K. [陳灌豪]. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4852168 ; http://dx.doi.org/10.5353/th_b4852168 ; http://hdl.handle.net/10722/179977

► Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by acute myelitis (AM) and optic neuritis (ON), especially clinically severe… (more)

▼ Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by acute myelitis (AM) and optic neuritis (ON), especially clinically severe longitudinally extensive transverse myelitis (LETM) and simultaneous bilateral ON. Patients with recurrent AM especially LETM without ON, and patients with recurrent ON without AM may have disorders belonging to the spectrum of NMO, neuromyelitis optica spectrum disorders (NMOSD). NMO is likely autoimmune in nature as a significant proportion of patients are seropositive for aquaporin-4 (AQP4) autoantibodies. I studied the clinical features of local Chinese NMOSD patients and their AQP4 autoantibodies seropositivity rates of by indirect immunofluorescence using tissue slides containing primate cerebellum (tissued-based immunofluorescence assay) in patients with 1) NMO, 2) classical multiple sclerosis (CMS), 3) acute disseminated encephalomyelitis (ADEM), 4) single attack or relapsing AM, 5) single attack or relapsing ON, and 6) other neurological disorders. The results showed that NMOSD are severe CNS IDD affecting patients with a wide range of onset ages. Chinese NMOSD patients predominantly have relapsing NMO and relapsing LETM with severe attack of LETM and/or ON. The six-year mortality rate of patients with NMO or relapsing myelitis with LETM was about 12%. Two-thirds of patients have poor neurological outcome at a mean duration of 6.0 years. The results confirmed that AQP4 autoantibodies are specific for NMOSD, and detection of AQP4 autoantibodies is clinically useful for early diagnosis of NMOSD and distinction from CMS. I proceeded to study a cell-based immunofluorescence assay using transfected human embryonic kidney cells overexpressing human AQP4 on cell membrane and found that cell-based assay has higher sensitivity than tissue-based assay in detection of AQP4 autoantibodies in NMO (78% versus 61%). As our NMOSD patients frequently presented clinically with severe brainstem symptoms and signs and lesions in brainstem and other brain regions on magnetic resonance imaging (MRI), I studied the clinical and neuroradiological characteristics of Chinese NMOSD patients with brain involvement. I found that 59% of NMOSD patients have clinical and/or radiological evidence of brain involvement. Importantly, brainstem is the most frequently affected brain region and 24% of NMOSD patients had clinical manifestation of brainstem encephalitis. I also studied the pathogenicity of AQP4 autoantibodies in the absence of complement activation by passive transfer of IgG isolated from sera of NMOSD patients into mice pretreated with complete Freund’s adjuvant (CFA, containing heat-killed mycobacterium tuberculosis) and pertussis toxin (PTx). I observed that pretreatment with CFA and PTx led to breach of BBB in mouse, and IgG isolated from sera of NMOSD patients seropositive for AQP4 autoantibodies led to asymptomatic loss of AQP4 in gray and white matter in mouse spinal cord without inflammatory cell infiltration, demyelination or… Advisors/Committee Members: Ho, SL.

Subjects/Keywords: Optic nerve - Diseases.; Spinal cord - Diseases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chan, K. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Doctoral Dissertation). University of Hong Kong. Retrieved from Chan, K. [陳灌豪]. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4852168 ; http://dx.doi.org/10.5353/th_b4852168 ; http://hdl.handle.net/10722/179977

Chicago Manual of Style (16^th Edition):

Chan, Koon-ho. “Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders.” 2012. Doctoral Dissertation, University of Hong Kong. Accessed February 18, 2020. Chan, K. [陳灌豪]. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4852168 ; http://dx.doi.org/10.5353/th_b4852168 ; http://hdl.handle.net/10722/179977.

MLA Handbook (7^th Edition):

Chan, Koon-ho. “Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders.” 2012. Web. 18 Feb 2020.

Vancouver:

Chan K. Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. [Internet] [Doctoral dissertation]. University of Hong Kong; 2012. [cited 2020 Feb 18]. Available from: Chan, K. [陳灌豪]. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4852168 ; http://dx.doi.org/10.5353/th_b4852168 ; http://hdl.handle.net/10722/179977.

Council of Science Editors:

Chan K. Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. [Doctoral Dissertation]. University of Hong Kong; 2012. Available from: Chan, K. [陳灌豪]. (2012). Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4852168 ; http://dx.doi.org/10.5353/th_b4852168 ; http://hdl.handle.net/10722/179977

University of Zambia

18. Kakumbi, Bernard. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .

Degree: 2011, University of Zambia

URL: http://hdl.handle.net/123456789/445

► The effect of vesicular arbuscular mycorrhiza (VAM) and rhizosphere pseudomonads on chickpea (Cicer arietinum L.) wilt caused by Fusarium oxysporum f. sp. ciceri (Matuo and… (more)

▼ The effect of vesicular arbuscular mycorrhiza (VAM) and rhizosphere pseudomonads on chickpea (Cicer arietinum L.) wilt caused by Fusarium oxysporum f. sp. ciceri (Matuo and Sato) in Zambia was investigated. Vesicular arbuscular mycorrhiza was isolated from three soils obtained from Kasama area of Lusaka. Rhizosphere pseudomonads were isolated from a chickpea farm in the same area. Physical and chemical characteristics of the soils were analyzed. Both VAM and pseudomonads were characterized and identified. The mycorrhizal flora of the three soils consisted of Glomus etunicatum, Gigaspora nigra and Acaulospora scrobiculata. This composite mycorrhizal flora and rhizosphere pseudomonads were used to determine their effect on fusarium wilt of chickpea. Their effect on growth and productivity of the crop was also investigated. The study was carried out between December 2006 and April 2007 in a greenhouse at the School of Agriculture of the University of Zambia. The VAM flora was amplified for a period of eight weeks by planting surface sterilized seeds of maize variety MMV 600 in heat sterilized soil. Vesicular arbuscular mycorrhiza soil inoculums was mixed in proportions of 3 sterilized soil to 1 VAM soil portion (1 portion equals 1.5kg amplified VAM soil) for use in two of the four treatments. A complete randomized block experimental block design was used with four treatments and four replications. Surface disinfected SPGR-4869 chickpea seeds were planted in the soil mixtures in plastic pots in a greenhouse. The four treatments consisted of the following: A. A combination of fusarium wilts pathogen, sterilized soil and chickpea seeds. B. Fusarium wilt pathogen, pseudomonads, sterilized soil and chickpea seeds. C. Fusarium wilt pathogen, VAM, sterilized soil and chickpea seeds. D. Fusarium wilt pathogen, pseudomonads, VAM, sterilized soil and chickpea seeds. A conidial suspension of 2 cm containing 5.07 x 104 micro conidia of Fusarium oxysporum f.sp. ciceri were inoculated per plant at the time of sowing. For treatments C and D colony forming units (cfu) of 105 of pseudomonad bacterial extract (turbidity 27.20 mg/L at 430nm) was inoculated per plant. The plants were watered with tap water at intervals of 48 hours. Chickpea plants were examined at fifteen days intervals from 15 to 90 days after sowing (DAS) to measure plant height, the number of leaves, flowers and pods per plant. At 90 (DAS) seed weight per plant, fresh shoot weight, fresh root weight and disease incidence were recorded. The results show that there was 52% reduction of fusarium wilt in chickpea inoculated with VAM and pseudomonads (dual inoculation) compared to the control. Single inoculation of VAM showed 50% reduction of fusarium wilt in chickpea plants. The analysis of variance (ANOVA) of the measured parameters indicated that the dual inoculation (VAM and pseudomonads) enhanced growth and development of chickpea plants by 16% compared to the control and produced taller plants with more leaves, flowers and a high shoot and…

Subjects/Keywords: Plant Diseases – Zambia; Plant Diseases – Diagnosis – Zambia

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APA (6^th Edition):

Kakumbi, B. (2011). The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kakumbi, Bernard. “The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .” 2011. Thesis, University of Zambia. Accessed February 18, 2020. http://hdl.handle.net/123456789/445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kakumbi, Bernard. “The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia .” 2011. Web. 18 Feb 2020.

Vancouver:

Kakumbi B. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . [Internet] [Thesis]. University of Zambia; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/123456789/445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kakumbi B. The effect of Vesicular-Arbusclar Mycorrhiza and Rhizospherepseudomonads on Chickpea Wilt in Zambia . [Thesis]. University of Zambia; 2011. Available from: http://hdl.handle.net/123456789/445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University

19. Bueno, Rudolfo. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.

Degree: Master of Veterinary Studies, 2015, Massey University

URL: http://hdl.handle.net/10179/6805

► Ostreid herpesvirus-1 (OsHV-1) was associated with summer mortalities in New Zealand Pacific oysters in 2010-2011. During the mortality investigation, a cohort of Pacific oyster spat,… (more)

Subjects/Keywords: Pacific oysters; Crassostrea gigas; Diseases; Herpesvirus diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bueno, R. (2015). Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/6805

Chicago Manual of Style (16^th Edition):

Bueno, Rudolfo. “Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.” 2015. Masters Thesis, Massey University. Accessed February 18, 2020. http://hdl.handle.net/10179/6805.

MLA Handbook (7^th Edition):

Bueno, Rudolfo. “Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand.” 2015. Web. 18 Feb 2020.

Vancouver:

Bueno R. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. [Internet] [Masters thesis]. Massey University; 2015. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10179/6805.

Council of Science Editors:

Bueno R. Ostreid herpesvirus-1 infection in Pacific oysters (Crassostrea gigas) – New Zealand. [Masters Thesis]. Massey University; 2015. Available from: http://hdl.handle.net/10179/6805

University of Cambridge

20. Greene, Daniel John. Methods for determining the genetic causes of rare diseases.

Degree: PhD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/270546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744446

► Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel… (more)

▼ Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel disease aetiologies, increase our understanding of biological processes and improve patient care. However, the power to discover the genetic causes of many unexplained rare diseases is hindered by a paucity of cases with a shared molecular aetiology. This thesis presents research into statistical and computational methods for determining the genetic causes of rare diseases. Methods described herein treat important aspects of the nature of rare diseases, including genetic and phenotypic heterogeneity, phenotypes involving multiple organ systems, Mendelian modes of inheritance and the incorporation of complex prior information such as model organism phenotypes and evolutionary conservation. The complex nature of rare disease phenotypes and the need to aggregate patient data across many centres has led to the adoption of the Human Phenotype Ontology (HPO) as a means of coding patient phenotypes. The HPO provides a standardised vocabulary and captures relationships between disease features. I developed a suite of software packages dubbed 'ontologyX' in order to simplify analysis and visualisation of such ontologically encoded data, and enable them to be incorporated into complex analysis methods. An important aspect of the analysis of ontological data is quantifying the semantic similarity between ontologically annotated entities, which is implemented in the ontologyX software. We employed this functionality in a phenotypic similarity regression framework, 'SimReg', which models the relationship between ontologically encoded patient phenotypes of individuals and rare variation in a given genomic locus. It does so by evaluating support for a model under which the probability that a person carries rare alleles in a locus depends on the similarity between the person's ontologically encoded phenotype and a latent characteristic phenotype which can be inferred from data. A probability of association is computed by comparison of the two models, allowing prioritisation of candidate loci for involvement in disease with respect to a heterogeneous collection of disease phenotypes. SimReg includes a sophisticated treatment of HPO-coded phenotypic data but dichotomises the genetic data at a locus. Therefore, we developed an additional method, 'BeviMed', standing for Bayesian Evaluation of Variant Involvement in Mendelian Disease, which evaluates the evidence of association between allele configurations across rare variants within a genomic locus and a case/control label. It is capable of inferring the probability of association, and conditional on association, the probability of each mode of inheritance and probability of involvement of each variant. Inference is performed through a Bayesian comparison of multiple models: under a baseline model disease risk is independent of allele configuration at the given rare variant sites and under an alternate model disease…

Subjects/Keywords: Bayesian statistics; Rare diseases; Ontologies; Genetic diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Greene, D. J. (2018). Methods for determining the genetic causes of rare diseases. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/270546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744446

Chicago Manual of Style (16^th Edition):

Greene, Daniel John. “Methods for determining the genetic causes of rare diseases.” 2018. Doctoral Dissertation, University of Cambridge. Accessed February 18, 2020. https://www.repository.cam.ac.uk/handle/1810/270546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744446.

MLA Handbook (7^th Edition):

Greene, Daniel John. “Methods for determining the genetic causes of rare diseases.” 2018. Web. 18 Feb 2020.

Vancouver:

Greene DJ. Methods for determining the genetic causes of rare diseases. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2020 Feb 18]. Available from: https://www.repository.cam.ac.uk/handle/1810/270546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744446.

Council of Science Editors:

Greene DJ. Methods for determining the genetic causes of rare diseases. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/270546 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744446

21. Kakandelwa, Cliff. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.

Degree: 2015, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4185

► Giardia is an intestinal protozoan parasite of mammals including humans. The objectives of the cross sectional study conducted between May 2013 and April 2014 were… (more)

▼ Giardia is an intestinal protozoan parasite of mammals including humans. The objectives of the cross sectional study conducted between May 2013 and April 2014 were to estimate the prevalence of Giardia infections in dairy herds on farms in Chilanga and Lusaka districts of Lusaka Province, Zambia, and to evaluate risk factors associated with the infections. Farms were grouped into smallholder and commercial farms. A total of 377 calves aged one day to one year were sampled from 34 farms. All the 377 faecal samples were analyzed for Giardia antigen using a commercially available monoclonal antibody-based Enzyme-linked immunosorbent assay kit. Chi square and Fisher’s exact tests were used and binary logistic regression was used to evaluate factors associated with infections. The overall prevalence of Giardia for the two districts was 34.5% (130/377; 95% CI= 29.7-39.3) while the overall farm prevalence was 79.4% (27/34). For individual smallholder farms, the animal level prevalence of Giardia ranged from zero to 100% and within commercial herds, it was 12.5% to 60.9%. The prevalence was significantly higher in calves up to three months old than in older ones (p = 0.010). There was no significant difference in the prevalence of Giardia between smallholder and commercial dairy farms (p = 0.300) and this was also the case between male and female calves (p = 0.633). The present study did not find a clear association between presence of Giardia in faecal samples and occurrence of diarrhoea in calves (p = 0.205). v Several management factors were evaluated, however, only husbandry system was found to be a significant risk factor for infection with the parasite. It was found that herds reared under intensive husbandry system were 2.083 (95% CI = 1.086-59.308, p = 0.041) times more likely to be positive for Giardia than those under free range system. The findings of the present study demonstrate that Giardia infections are common in dairy herds in Chilanga and Lusaka districts especially in calves up to three months of age which may play an important role in the epidemiology of giardiasis. Furthermore, husbandry system is an important factor in the perpetuation of the infections.

Subjects/Keywords: GIARDIA Infections; Cattle Diseases; Domestic Animals-Diseases

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APA (6^th Edition):

Kakandelwa, C. (2015). Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kakandelwa, Cliff. “Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.” 2015. Thesis, University of Zimbabwe. Accessed February 18, 2020. http://dspace.unza.zm/handle/123456789/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kakandelwa, Cliff. “Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka.” 2015. Web. 18 Feb 2020.

Vancouver:

Kakandelwa C. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2020 Feb 18]. Available from: http://dspace.unza.zm/handle/123456789/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kakandelwa C. Prevalence and risk factors of GIARDIA infections in Dairy Cattle Herds in Lusaka and Chilanga Districts of Lusaka. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

22. Allardyce, Jane. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.

Degree: School of Life and Environmental Sciences, 2011, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30036706

► The plant pathogen <i>Phytophthora cinnamomi </i>causes devastating disease in natural and agricultural systems worldwide. While some plants can survive, little is known about the… (more)

Subjects/Keywords: plant pathology; plant diseases; ‬phytophthora cinnamomi diseases

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APA (6^th Edition):

Allardyce, J. (2011). Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30036706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Allardyce, Jane. “Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.” 2011. Thesis, Deakin University. Accessed February 18, 2020. http://hdl.handle.net/10536/DRO/DU:30036706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Allardyce, Jane. “Defence mechanisms of a resistant monocot model to phytophthora cinnamomi.” 2011. Web. 18 Feb 2020.

Vancouver:

Allardyce J. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. [Internet] [Thesis]. Deakin University; 2011. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/10536/DRO/DU:30036706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Allardyce J. Defence mechanisms of a resistant monocot model to phytophthora cinnamomi. [Thesis]. Deakin University; 2011. Available from: http://hdl.handle.net/10536/DRO/DU:30036706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

23. Zani, Stavrina. Pharmacotherapy Of Autoimmune Diseases .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194730

► Autoimmune diseases are chronic, potential life threatening multisystem disorders which attack an individual's own immune system and destroy healthy cells and tissues.Autoimmune diseases are classified… (more)

Subjects/Keywords: Autoimmune Diseases; Treatment Of Autoimmune Diseases

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APA (6^th Edition):

Zani, S. (2014). Pharmacotherapy Of Autoimmune Diseases . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zani, Stavrina. “Pharmacotherapy Of Autoimmune Diseases .” 2014. Thesis, University of Debrecen. Accessed February 18, 2020. http://hdl.handle.net/2437/194730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zani, Stavrina. “Pharmacotherapy Of Autoimmune Diseases .” 2014. Web. 18 Feb 2020.

Vancouver:

Zani S. Pharmacotherapy Of Autoimmune Diseases . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/2437/194730.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zani S. Pharmacotherapy Of Autoimmune Diseases . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194730

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Greene, Daniel, John. Methods for Determining the Genetic Causes of Rare Diseases.

Degree: PhD, 2018, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/270546

► Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel… (more)

▼ Thanks to the affordability of DNA sequencing, hundreds of thousands of individuals with rare disorders are undergoing whole-genome sequencing in an effort to reveal novel disease aetiologies, increase our understanding of biological processes and improve patient care. However, the power to discover the genetic causes of many unexplained rare diseases is hindered by a paucity of cases with a shared molecular aetiology. This thesis presents research into statistical and computational methods for determining the genetic causes of rare diseases. Methods described herein treat important aspects of the nature of rare diseases, including genetic and phenotypic heterogeneity, phenotypes involving multiple organ systems, Mendelian modes of inheritance and the incorporation of complex prior information such as model organism phenotypes and evolutionary conservation. The complex nature of rare disease phenotypes and the need to aggregate patient data across many centres has led to the adoption of the Human Phenotype Ontology (HPO) as a means of coding patient phenotypes. The HPO provides a standardised vocabulary and captures relationships between disease features. I developed a suite of software packages dubbed 'ontologyX' in order to simplify analysis and visualisation of such ontologically encoded data, and enable them to be incorporated into complex analysis methods. An important aspect of the analysis of ontological data is quantifying the semantic similarity between ontologically annotated entities, which is implemented in the ontologyX software. We employed this functionality in a phenotypic similarity regression framework, 'SimReg', which models the relationship between ontologically encoded patient phenotypes of individuals and rare variation in a given genomic locus. It does so by evaluating support for a model under which the probability that a person carries rare alleles in a locus depends on the similarity between the person's ontologically encoded phenotype and a latent characteristic phenotype which can be inferred from data. A probability of association is computed by comparison of the two models, allowing prioritisation of candidate loci for involvement in disease with respect to a heterogeneous collection of disease phenotypes. SimReg includes a sophisticated treatment of HPO-coded phenotypic data but dichotomises the genetic data at a locus. Therefore, we developed an additional method, 'BeviMed', standing for Bayesian Evaluation of Variant Involvement in Mendelian Disease, which evaluates the evidence of association between allele configurations across rare variants within a genomic locus and a case/control label. It is capable of inferring the probability of association, and conditional on association, the probability of each mode of inheritance and probability of involvement of each variant. Inference is performed through a Bayesian comparison of multiple models: under a baseline model disease risk is independent of allele configuration at the given rare variant sites and under an alternate model…

Subjects/Keywords: Bayesian statistics; Rare diseases; Ontologies; Genetic diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Greene, Daniel, J. (2018). Methods for Determining the Genetic Causes of Rare Diseases. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/270546

Chicago Manual of Style (16^th Edition):

Greene, Daniel, John. “Methods for Determining the Genetic Causes of Rare Diseases.” 2018. Doctoral Dissertation, University of Cambridge. Accessed February 18, 2020. https://www.repository.cam.ac.uk/handle/1810/270546.

MLA Handbook (7^th Edition):

Greene, Daniel, John. “Methods for Determining the Genetic Causes of Rare Diseases.” 2018. Web. 18 Feb 2020.

Vancouver:

Greene, Daniel J. Methods for Determining the Genetic Causes of Rare Diseases. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2020 Feb 18]. Available from: https://www.repository.cam.ac.uk/handle/1810/270546.

Council of Science Editors:

Greene, Daniel J. Methods for Determining the Genetic Causes of Rare Diseases. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/handle/1810/270546

25. Lewis, M. H. Peripheral arterial disease from aetiology to surgical management.

Degree: PhD, 2013, University of South Wales

URL: https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749704

► The work presented includes over thirty peer reviewed published manuscripts based on studies undertaken during my surgical career. As Principal Investigator, I led the study… (more)

Subjects/Keywords: Arteries – Diseases; Arteries – Surgery; Peripheral vascular diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lewis, M. H. (2013). Peripheral arterial disease from aetiology to surgical management. (Doctoral Dissertation). University of South Wales. Retrieved from https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749704

Chicago Manual of Style (16^th Edition):

Lewis, M H. “Peripheral arterial disease from aetiology to surgical management.” 2013. Doctoral Dissertation, University of South Wales. Accessed February 18, 2020. https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749704.

MLA Handbook (7^th Edition):

Lewis, M H. “Peripheral arterial disease from aetiology to surgical management.” 2013. Web. 18 Feb 2020.

Vancouver:

Lewis MH. Peripheral arterial disease from aetiology to surgical management. [Internet] [Doctoral dissertation]. University of South Wales; 2013. [cited 2020 Feb 18]. Available from: https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749704.

Council of Science Editors:

Lewis MH. Peripheral arterial disease from aetiology to surgical management. [Doctoral Dissertation]. University of South Wales; 2013. Available from: https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.749704

University of Nevada – Las Vegas

26. Sabbagh, Jonathan J. Donepezil and galanin interactions in an animal model of Alzheimer’s disease.

Degree: MAin Psychology, Psychology, 2010, University of Nevada – Las Vegas

URL: https://digitalscholarship.unlv.edu/thesesdissertations/771

► Alzheimer's disease (AD) is a neurodegenerative disorder marked by a progressive loss of cognitive function. One of the neurobiological hallmarks of AD is a… (more)

Subjects/Keywords: Diseases; Nervous System Diseases; Neurosciences; Pathology

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APA (6^th Edition):

Sabbagh, J. J. (2010). Donepezil and galanin interactions in an animal model of Alzheimer’s disease. (Masters Thesis). University of Nevada – Las Vegas. Retrieved from https://digitalscholarship.unlv.edu/thesesdissertations/771

Chicago Manual of Style (16^th Edition):

Sabbagh, Jonathan J. “Donepezil and galanin interactions in an animal model of Alzheimer’s disease.” 2010. Masters Thesis, University of Nevada – Las Vegas. Accessed February 18, 2020. https://digitalscholarship.unlv.edu/thesesdissertations/771.

MLA Handbook (7^th Edition):

Sabbagh, Jonathan J. “Donepezil and galanin interactions in an animal model of Alzheimer’s disease.” 2010. Web. 18 Feb 2020.

Vancouver:

Sabbagh JJ. Donepezil and galanin interactions in an animal model of Alzheimer’s disease. [Internet] [Masters thesis]. University of Nevada – Las Vegas; 2010. [cited 2020 Feb 18]. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/771.

Council of Science Editors:

Sabbagh JJ. Donepezil and galanin interactions in an animal model of Alzheimer’s disease. [Masters Thesis]. University of Nevada – Las Vegas; 2010. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/771

University of Texas Southwestern Medical Center

27. Benjamin, Jamaal Louis. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1571

► The intestines of all mammals are colonized with a diverse microbiota that provide metabolic benefits to their hosts. However, this symbiotic relationship can break down… (more)

Subjects/Keywords: Inflammatory Bowel Diseases; Autophagy; Intestinal Diseases

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APA (6^th Edition):

Benjamin, J. L. (2013). Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Benjamin, Jamaal Louis. “Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed February 18, 2020. http://hdl.handle.net/2152.5/1571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Benjamin, Jamaal Louis. “Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine.” 2013. Web. 18 Feb 2020.

Vancouver:

Benjamin JL. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2020 Feb 18]. Available from: http://hdl.handle.net/2152.5/1571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Benjamin JL. Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

28. Santorelli, Melissa L., 1975-. Chronic disease outcomes among older women with breast cancer in the united states.

Degree: PhD, Public Health, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

►

Context: Improving survival has raised important questions about the long term health of breast cancer patients, particularly for older women who experience the highest incidence… (more)

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Context: Improving survival has raised important questions about the long term health of breast cancer patients, particularly for older women who experience the highest incidence and who are more likely to have or develop other chronic health conditions. Specific Aims: The specific aims of this dissertation were to: 1) Examine racial differences in the effects of comorbidity on survival in elderly breast cancer patients (Study 1); 2) Investigate the effects of breast cancer on chronic disease medication adherence in the elderly (Study 2); and 3) Investigate the effects of hormonal therapy for breast cancer on diabetes incidence in postmenopausal women (Study 3). Design, Setting, and Subjects: The Surveillance, Epidemiology and End Results (SEER) – Medicare linked data were used to select stage I-III breast cancer patients for the above retrospective cohort studies. Women from a 5% random sample of Medicare enrollees living in SEER areas were selected as comparison subjects for studies two and three. Results: A competing risk survival analysis in the first study failed to find racial differences in the effects of comorbidity on breast cancer mortality after adjusting for age, year of diagnosis, and tumor characteristics. For other-cause mortality, the magnitude of adverse comorbidity effects were larger for white women overall (p=0.04). The second study showed an elevated risk of diabetes medication non-adherence for breast cancer versus comparison women after adjusting for age and race [Odds Ratio (OR) = 1.41; 95% Confidence Interval (CI) = 1.05 to 1.90]. Women with breast cancer were also more likely to be non-persistent with diabetes medication relative to women without cancer [Hazard Ratio (HR) = 1.29; 95% CI: 1.02 to 1.62]. The third study found no association between aromatase inhibitor use and new onset diabetes in the two years post-treatment initiation after adjusting for age, race, and comorbidity [HR: 0.99; 95% CI: 0.84 to 1.18]. Conclusion: The findings of this dissertation provide evidence that breast cancer affects chronic disease medication adherence and that hormonal therapy was not associated with the development of a new comorbidity. Special attention should be given to following breast cancer patients to ensure treatment of their comorbid conditions.

Advisors/Committee Members: DEMISSIE, KITAW (chair), Steinberg, Michael B (internal member), Rhoads, George G (internal member), LIN, YONG (internal member), Hirshfield, Kim M (outside member).

Subjects/Keywords: Chronic diseases; Breast – Cancer; Older women – Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santorelli, Melissa L., 1. (2015). Chronic disease outcomes among older women with breast cancer in the united states. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

Chicago Manual of Style (16^th Edition):

Santorelli, Melissa L., 1975-. “Chronic disease outcomes among older women with breast cancer in the united states.” 2015. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/47575/.

MLA Handbook (7^th Edition):

Santorelli, Melissa L., 1975-. “Chronic disease outcomes among older women with breast cancer in the united states.” 2015. Web. 18 Feb 2020.

Vancouver:

Santorelli, Melissa L. 1. Chronic disease outcomes among older women with breast cancer in the united states. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/.

Council of Science Editors:

Santorelli, Melissa L. 1. Chronic disease outcomes among older women with breast cancer in the united states. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47575/

Rutgers University

29. Pyne, Robert M., 1988-. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).

Degree: PhD, Plant Biology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

►

Sweet basil (Ocimum basilicum) is among the most widely cultivated culinary herbs in the United States, Western Europe and Israel. Despite relative economic importance, breeding… (more)

▼

Sweet basil (Ocimum basilicum) is among the most widely cultivated culinary herbs in the United States, Western Europe and Israel. Despite relative economic importance, breeding and genetic study of this plant species has been largely neglected, rendering its >3 Gbp genome largely unexplored. The deficit in available O. basilicum genetic and genomic resources has been highlighted by a worldwide downy mildew epidemic caused by obligate oomycete Peronospora belbahrii, which has yet to be mediated by disease resistant varieties. The goal of this dissertation research was to narrow the information gap preventing an effective disease resistance breeding response. Specific objectives were to: 1) determine population structure and estimate genetic diversity among a panel of downy mildew resistant and susceptible Ocimum spp. accessions, 2) identify mode of inheritance for resistance to downy mildew in a full-sibling family and 3) construct a linkage map for detection of quantitative trait loci (QTL) associated with DM resistance. A nested, model-based cluster analysis demonstrated three major delineations within the Ocimum genus with additional evidence for cryptic structure, especially within the economically important k1 O. basilicum cluster. Distribution of DM resistance was concentrated outside the k1 O. basilicum cluster with the exception of a single k1 genotype, ‘MRI’. Analysis of downy mildew response across F2 and backcross populations over two years and two locations demonstrated major gene control of downy mildew resistance conferred by MRI. Finally, a restriction site associated DNA sequencing (RADseq) approach facilitated the discovery and mapping of >1,800 single nucleotide polymorphism (SNP) and expressed sequence tag simple sequence repeat (EST-SSR) markers. The resulting genetic map was validated by the detection of a major QTL, dm11.1, which explained 38-55% of the phenotypic variance observed for the MRI x SB22 F2 mapping population. Disomic inheritance of SNP and SSR markers support previous cytological evidence that basil has evolved an allopolyploid genome. Results of this dissertation provide the most robust phylogenetic examination of the Ocimum genus to date, characterization of DM heritability across multiple environments and the first report of genetic/QTL mapping for O. basilicum. A current case study is provided for the feasibility of breeding a non-model plant species using classical genetic theory in combination with modern genomic technologies.

Advisors/Committee Members: Simon, James (chair), Bonos, Stacy (internal member), Wyenandt, Andrew (internal member), Wehner, Todd (outside member).

Subjects/Keywords: Basil – Diseases and pests; Downy mildew diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pyne, Robert M., 1. (2017). Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

Chicago Manual of Style (16^th Edition):

Pyne, Robert M., 1988-. “Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).” 2017. Doctoral Dissertation, Rutgers University. Accessed February 18, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/53965/.

MLA Handbook (7^th Edition):

Pyne, Robert M., 1988-. “Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum).” 2017. Web. 18 Feb 2020.

Vancouver:

Pyne, Robert M. 1. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2020 Feb 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/.

Council of Science Editors:

Pyne, Robert M. 1. Introgression of genetic resistance to downy mildew (peronospora belbahrii) in a non-model plant species, sweet basil (ocimum basilicum). [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/53965/

30. Fitzgerald, Julia. Monoamine oxidase in neuronal cell death.

Degree: PhD, 2008, Nottingham Trent University

URL: http://irep.ntu.ac.uk/id/eprint/51/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493065

► Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and… (more)

▼ Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product. MAO is localised in the outer mitochondrial membrane and exists as two isoforms, MAO-A and MAO-B, which are differentially expressed in the body and differ in their substrate and inhibitor specificities. Previous studies have suggested that MAO-generated reactive oxygen species (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, cause damage to mitochondrial DNA and enhance cell death signalling. In this study the role of MAO in cell death was investigated in dopaminergic neuroblastoma (SH-SY5Y) cells, in three diverse models of mitochondrially-mediated apoptosis. The relevance of MAO in cell death signalling was confirmed with the use of two unrelated MAO inhibitors and the creation of stable SH-SY5Y cell lines that either over express MAO-A or have reduced levels of MAO-A. The study is the first to over express MAO-A using recombinant technology and to use miRNA to stably knock-down MAO-A expression in human neuronal cells. Results confirm that MAO-A is involved in modulating cell death but the mechanism and extent of the involvement depends on the apoptotic inducer. In classical apoptosis induced by staurosporine (STS), cells undergo rapid morphological and biochemical changes indicative of mitochondrially-mediated apoptosis, which is partly dependent on ROS production by MAO-A and induction of mitogen-activated protein kinase (MAPK) signalling cascades. MAO-A protein and catalytic activity are increased in this model, however the mechanism by which this occurs is unknown and is not a result of increased gene transcription. In death induced by growth factor withdrawal, the MAO-A gene is up regulated via p38 and JNK MAPK pathways, which occurs downstream of caspase activation. In both the STS and growth factor withdrawal models, MAO inhibition reduced apoptosis. Most significantly reduced levels of MAO-A expression in 'knock down' cells protected against cell death induced by the complex I inhibitor rotenone, suggesting that MAO has an important role in mitochondrial function. Over expression of MAO-A resulted in stress and apoptosis, followed by a period of cellular senescence and eventually death by necrosis. These data compliment the effects of chronic exposure to oxidative stress in ageing and neurodegeneration. For the first time this work has shown that the MAO-A isoform is an important regulator of STS-induced apoptosis, that MAO-A gene expression is regulated by JNK signalling, and that MAO-A is significantly involved in mitochondrial dysfunction induced by complex I inhibition. These data raise important questions regarding predisposition to the development of neurodegenerative diseases such as Parkinson's disease and to approaches used for their treatment.

Subjects/Keywords: 616.8; Neurodegenerative diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fitzgerald, J. (2008). Monoamine oxidase in neuronal cell death. (Doctoral Dissertation). Nottingham Trent University. Retrieved from http://irep.ntu.ac.uk/id/eprint/51/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493065

Chicago Manual of Style (16^th Edition):

Fitzgerald, Julia. “Monoamine oxidase in neuronal cell death.” 2008. Doctoral Dissertation, Nottingham Trent University. Accessed February 18, 2020. http://irep.ntu.ac.uk/id/eprint/51/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493065.

MLA Handbook (7^th Edition):

Fitzgerald, Julia. “Monoamine oxidase in neuronal cell death.” 2008. Web. 18 Feb 2020.

Vancouver:

Fitzgerald J. Monoamine oxidase in neuronal cell death. [Internet] [Doctoral dissertation]. Nottingham Trent University; 2008. [cited 2020 Feb 18]. Available from: http://irep.ntu.ac.uk/id/eprint/51/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493065.

Council of Science Editors:

Fitzgerald J. Monoamine oxidase in neuronal cell death. [Doctoral Dissertation]. Nottingham Trent University; 2008. Available from: http://irep.ntu.ac.uk/id/eprint/51/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493065

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