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University of Guelph
1.
Ahmad, Saira.
A Genetic Algorithm Approach to Exploring Simulation Parameters.
Degree: MS, Department of Computing and Information Science, 2012, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3996 
► Simulation of animal disease spread is essential for understanding and controlling the outbreak of disease among herds of livestock (in particular cattle and poultry). Using…
(more)
▼ Simulation of animal disease spread is essential for understanding and controlling the outbreak of disease among herds of livestock (in particular cattle and poultry). Using a computerized system or simulator, animal health professionals or epidemiologists often spend many hours determining the set of input parameters that most accurately represent a disease spread or an outbreak scenario. A parameter can be a simple boolean value, or a scientific or often hypothetically derived range of real numbers. Many times, an epidemiologist chooses a value provisionally in a random fashion and repeats the simulation until a viable solution is achieved. This tedious process is inefficient and lengthy. To assist and improve this laborious practice in a concise and timely manner, a Genetic Algorithm is employed to determine a population based solution consisting of input parameters using the North American Animal Disease Spread Model (NAADSM).
Subjects/Keywords: Genetic Algorithm; animal disease spread simulator; stochastic simulation; simulation; simulation parameters
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APA (6th Edition):
Ahmad, S. (2012). A Genetic Algorithm Approach to Exploring Simulation Parameters. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3996
Chicago Manual of Style (16th Edition):
Ahmad, Saira. “A Genetic Algorithm Approach to Exploring Simulation Parameters.” 2012. Masters Thesis, University of Guelph. Accessed March 05, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3996.
MLA Handbook (7th Edition):
Ahmad, Saira. “A Genetic Algorithm Approach to Exploring Simulation Parameters.” 2012. Web. 05 Mar 2021.
Vancouver:
Ahmad S. A Genetic Algorithm Approach to Exploring Simulation Parameters. [Internet] [Masters thesis]. University of Guelph; 2012. [cited 2021 Mar 05].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3996.
Council of Science Editors:
Ahmad S. A Genetic Algorithm Approach to Exploring Simulation Parameters. [Masters Thesis]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3996
Kansas State University
2.
Trupka, Andrew Tristan.
Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber.
Degree: MS, Department of Mechanical and
Nuclear Engineering, 2011, Kansas State University
URL: http://hdl.handle.net/2097/8853
► In 2010, over 786 million passengers flew on commercial flights in the United States according to the Bureau of Transportation Statistics (2011). With the average…
(more)
▼ In 2010, over 786 million passengers flew on
commercial flights in the United States according to the Bureau of
Transportation Statistics (2011). With the average flight length
over 1300 miles for domestic flights, this amounts to billions of
hours spent aboard airliners by passengers each year. During these
flights, diseases and other harmful contaminates, some malicious,
can
spread throughout aircraft cabins, harming passengers. Aircraft
ventilation systems are designed to remove these harmful
contaminates as quickly as possible to minimize
spread in cabin
air. Disruptions to the design airflow pattern can hinder the
effectiveness of contamination removal efforts. A common form of
this airflow disruption is longitudinal air movement through cabin
aisles. To examine the effect of contaminate transport down
aircraft aisles by a moving body, a motorized beverage cart is past
by a contamination source as it traverses the length of the cabin
aisle.
An experimental study is performed in a mockup Boeing 767
cabin section consisting of eleven rows with seven seats per row.
Carbon Dioxide (CO2) tracer gas is injected at a constant flow rate
at a location of interest until concentrations in the cabin reach
steady state. Ventilation equipment and flow rates representative
of an actual aircraft are used for all experiments. Seats in the
mockup are occupied by thermal manikins to simulate passenger heat
load. A motorized beverage cart traverses the length of the cabin
aisle passing by the injection location. The concentrations of
tracer gas displaced by the cart are measured at locations
throughout the cabin. Comparing these measurements to baseline
readings taken with no cart movement, a map of the degree to which
contaminant transport is affected by the beverage cart is
calculated.
The cabin mockup is supplied by 100% outdoor air
through actual Boeing supply ductwork and linear diffusers along
the cabin length above the aisles. The CO2 level is measured in the
inlet air, measurement locations in the cabin, and exhaust air
using nondispersive infrared (NDIR) sensors. Measured results are
reported for all (54) seat locations downstream of the cart
traverse/injection location for an injection location near the rear
of the cabin. Analogous measurements are also conducted examining
the effect of variations in cart speed and modified injection
location.
It was found the beverage cart movement had an effect of
up to a 35% increase in tracer gas concentration relative to the
local steady state concentration for several seat locations
adjacent to the aisle. This increased concentration continued for
only a few minutes in all cases, but was generally less than the
steady state exposure one row closer to the injection location.
Moving in the lateral direction away from the aisle, the variance
in tracer gas concentration due to the cart movement diminished
quickly. The significance of increased concentration for such short
periods of time in comparison to the length of actual commercial
flights may require further biological analysis.…
Advisors/Committee Members: Mohammad H. HosniByron W. Jones.
Subjects/Keywords: Airliner
aisle movement; Aircraft
disease spread; Mechanical Engineering (0548)
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APA (6th Edition):
Trupka, A. T. (2011). Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/8853
Chicago Manual of Style (16th Edition):
Trupka, Andrew Tristan. “Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber.” 2011. Masters Thesis, Kansas State University. Accessed March 05, 2021.
http://hdl.handle.net/2097/8853.
MLA Handbook (7th Edition):
Trupka, Andrew Tristan. “Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber.” 2011. Web. 05 Mar 2021.
Vancouver:
Trupka AT. Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber. [Internet] [Masters thesis]. Kansas State University; 2011. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2097/8853.
Council of Science Editors:
Trupka AT. Tracer gas
mapping of beverage cart wake in a twin aisle aircraft cabin
simulation chamber. [Masters Thesis]. Kansas State University; 2011. Available from: http://hdl.handle.net/2097/8853
University of Georgia
3.
Whitley, Kari Rebecca.
Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/20478
► A soft rot of hosta, caused by an unknown agent, was observed at a large wholesale nursery in South Carolina in 1999. Losses ranged between…
(more)
▼ A soft rot of hosta, caused by an unknown agent, was observed at a large wholesale nursery in South Carolina in 1999. Losses ranged between 80 and 90 percent in the cultivated varieties Aureo-marginata and Golden Tiara that had been chilled
at 0°C in a refrigerated storage facility for 8-16 weeks to fulfill dormancy requirements. The causal agent of bacterial soft rot of hosta was determined to be Erwinia carotovora subsp. carotovora. Hosta plants spray-inoculated with suspensions of E.
carotovora subsp. carotovora developed soft rot following 24 hours cold storage at 0°C. Spread of disease occurred during cold storage of dormant hosta rhizome divisions and through vegetative propagation. Bactericides and disinfectants tested were
ineffective when used as a protectant prior to exposure to 0°C. Using polymerase chain reaction, specific primers ECC K and W were developed for the detection of E. carotovora subsp. carotovora.
Subjects/Keywords: Erwinia carotovora subsp. carotovora; Hosta spp.; Cold Storage; Disease Spread; Disease Management
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APA (6th Edition):
Whitley, K. R. (2014). Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/20478
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Whitley, Kari Rebecca. “Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora.” 2014. Thesis, University of Georgia. Accessed March 05, 2021.
http://hdl.handle.net/10724/20478.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Whitley, Kari Rebecca. “Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora.” 2014. Web. 05 Mar 2021.
Vancouver:
Whitley KR. Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/10724/20478.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Whitley KR. Development and detection of bacterial soft rot of Hosta spp. Tratt. caused by Erwinia carotovora subsp. Carotovora. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/20478
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Purdue University
4.
Sahar, Madih.
A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation.
Degree: MS, Electrical and Computer Engineering, 2014, Purdue University
URL: http://docs.lib.purdue.edu/open_access_theses/247
► Social interactions play an important role in spread of a disease. In this thesis we propose a probabilistic approach to synthesize an agent-based heterogeneous…
(more)
▼ Social interactions play an important role in
spread of a
disease. In this thesis we propose a probabilistic approach to synthesize an agent-based heterogeneous population interaction model to study the spatio-temporal dynamics of an air-born epidemic, such as influenza, in a metropolitan area. The proposed methodology is generic in nature and can generate a baseline population for the cities for which detailed population summary tables are not available. The joint probabilities of population demographics are estimated using the International Public Use Microsimulation Data (IPUMS) sample data set. Based on the population density and the socio-economic status, the population is divided into three types of residential areas. Agents, representing individuals, are assigned various activities based on their education, age, and gender. Since transportation can also influence the
spread of a
disease, this "activity," with a finite time span, is also assigned to individuals. The proposed approach is used for the city of Lahore, Pakistan. The agent-based model for Lahore is synthesized and a rule based
disease spread model of influenza is simulated for the city population. The simulation results are visualized to analyze the spatio-temporal dynamics of an influenza epidemic for Lahore.
Advisors/Committee Members: Arif Ghafoor, Walid Aref, Young Charlie Hu.
Subjects/Keywords: Applied sciences; Agent model; Baseline population; Disease spread; Epidemic; Joint distributions; Computer Engineering
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APA (6th Edition):
Sahar, M. (2014). A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation. (Thesis). Purdue University. Retrieved from http://docs.lib.purdue.edu/open_access_theses/247
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sahar, Madih. “A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation.” 2014. Thesis, Purdue University. Accessed March 05, 2021.
http://docs.lib.purdue.edu/open_access_theses/247.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sahar, Madih. “A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation.” 2014. Web. 05 Mar 2021.
Vancouver:
Sahar M. A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation. [Internet] [Thesis]. Purdue University; 2014. [cited 2021 Mar 05].
Available from: http://docs.lib.purdue.edu/open_access_theses/247.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sahar M. A Framework for Synthesizing Agent-Based Heterogeneous Population Model for Epidemic Simulation. [Thesis]. Purdue University; 2014. Available from: http://docs.lib.purdue.edu/open_access_theses/247
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Louisville
5.
Jin, Shengpeng.
Early detection and control of potential pandemics.
Degree: MS, 2011, University of Louisville
URL: 10.18297/etd/690
;
https://ir.library.louisville.edu/etd/690
► Early information is crucial for policy makers and public health officials responsible for protecting the public from the virulent spread of contagious diseases. Current…
(more)
▼ Early information is crucial for policy makers and public health officials responsible for protecting the public from the virulent
spread of contagious diseases. Current indicators of the
spread of contagious outbreaks lag behind the actual
spread of the epidemic, leaving no time for a planned response. The studies of Christakis et al. in 2010 have shown that social networks can provide more timely information for prediction. Our focus, however, is on the effective control of the
spread of contagious outbreaks in their early stages. We do this by defining a more effective way to chart the
spread of contagious outbreaks, in a spatio-temporal sense, so that effective control actions can be taken. In this paper, we use information from "sensors", such as, First Watch and EARS (Early Aberration Response Systems) and "central" individuals in social networks for early "spatio-temporal" prediction of virulent contagious outbreaks as a means to allocate resources to "nip a potential pandemic in the bud." Specifically we combine the research of Christakis et. al on social networks and that of Hongbo Yu on "spatio-temporal" prediction of human activities to chart the
spread of a virulent
disease.
Advisors/Committee Members: Alexander, Suraj Mammen.
Subjects/Keywords: Social network; Spatio-temporal interaction; Disease spread; Space-time path; Public health; Infection index
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APA (6th Edition):
Jin, S. (2011). Early detection and control of potential pandemics. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/690 ; https://ir.library.louisville.edu/etd/690
Chicago Manual of Style (16th Edition):
Jin, Shengpeng. “Early detection and control of potential pandemics.” 2011. Masters Thesis, University of Louisville. Accessed March 05, 2021.
10.18297/etd/690 ; https://ir.library.louisville.edu/etd/690.
MLA Handbook (7th Edition):
Jin, Shengpeng. “Early detection and control of potential pandemics.” 2011. Web. 05 Mar 2021.
Vancouver:
Jin S. Early detection and control of potential pandemics. [Internet] [Masters thesis]. University of Louisville; 2011. [cited 2021 Mar 05].
Available from: 10.18297/etd/690 ; https://ir.library.louisville.edu/etd/690.
Council of Science Editors:
Jin S. Early detection and control of potential pandemics. [Masters Thesis]. University of Louisville; 2011. Available from: 10.18297/etd/690 ; https://ir.library.louisville.edu/etd/690
University of Sydney
6.
Gabriele-Rivet, Vanessa.
Potential spread of rabies in dingo populations of northern Australia
.
Degree: 2020, University of Sydney
URL: http://hdl.handle.net/2123/24319
► Australia is free from canine rabies. The spread of the disease in Indonesia has increased the risk of rabies incursion in northern Australia. Remote Indigenous…
(more)
▼ Australia is free from canine rabies. The spread of the disease in Indonesia has increased the risk of rabies incursion in northern Australia. Remote Indigenous communities, such as those in the Northern Peninsula Area (NPA), contain large populations of free-roaming domestic dogs surrounded by dingo populations, creating optimal conditions for rabies establishment. A cross-sectional survey of NPA hunters revealed that hunting practices using domestic dogs create opportunities for dingo-dog interactions. Dingo purity analyses on scats of canine origin collected in the NPA region demonstrated that dingoes visit areas around the communities, increasing the likelihood of contact with roaming domestic dogs. A scoping review on the ecology of dingoes identified density, home range size and contacts between dingoes, three key ecological parameters for disease spread modelling, as major research gaps especially in northern Australia. Dingo population density and home range size in the NPA were estimated from spatially explicit mark-resight models based on data from a one-year camera-trap study. This study also revealed a substantial temporal overlap and spatial correlation in activity between dingoes and domestic dogs, further supporting the likelihood for disease spread at the wild-domestic interface. A novel spatial stochastic rabies spread model, which incorporated field-derived dingo ecological parameters and landscape heterogeneity specific to the NPA, predicted a high probability (59%) of spread to other packs following the introduction of the disease into the dingo population from a roaming or hunting domestic dog. Outbreaks were generally larger when rabies was introduced during the dry season and in areas around the communities. Overall, this research provides compelling evidence of the importance of improving Australia’s preparedness for a potential rabies incursion in high-risk areas, to prevent serious consequences in remote Indigenous communities.
Subjects/Keywords: Disease spread modelling; rabies; dingo; wild-domestic interface; Indigenous; Spatio-temporal epidemiology
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APA (6th Edition):
Gabriele-Rivet, V. (2020). Potential spread of rabies in dingo populations of northern Australia
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/24319
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gabriele-Rivet, Vanessa. “Potential spread of rabies in dingo populations of northern Australia
.” 2020. Thesis, University of Sydney. Accessed March 05, 2021.
http://hdl.handle.net/2123/24319.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gabriele-Rivet, Vanessa. “Potential spread of rabies in dingo populations of northern Australia
.” 2020. Web. 05 Mar 2021.
Vancouver:
Gabriele-Rivet V. Potential spread of rabies in dingo populations of northern Australia
. [Internet] [Thesis]. University of Sydney; 2020. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2123/24319.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gabriele-Rivet V. Potential spread of rabies in dingo populations of northern Australia
. [Thesis]. University of Sydney; 2020. Available from: http://hdl.handle.net/2123/24319
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Penn State University
7.
Lutz, Clayton Lee.
Dispersal Behavior in Female White-tailed Deer.
Degree: 2015, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/27216
► Dispersal is a common life-history trait across taxa and is ecologically important because it influences gene flow, population dynamics, colonization, and the spread of disease.…
(more)
▼ Dispersal is a common life-history trait across taxa and is ecologically important because it influences gene flow, population dynamics, colonization, and the
spread of
disease. The reasons animals disperse can be separated into two categories: proximate and ultimate causes. Proximate causes provide cues for dispersal to occur and can influence the characteristics of the dispersal event. Ultimate causes of dispersal refer to the evolutionary advantages of dispersal and why dispersal persists on the population level. Documenting an organism’s dispersal behavior and identifying factors that influence that behavior are crucial not only to understanding the basic ecology of a species, but also for providing critical information for the conservation and management of that species. Although dispersal is an important component of white-tailed deer (Odocoileus virginianus) ecology and management, it remains understudied and most analysis has focused on the dispersal of males. I investigated dispersal behavior patterns in female white-tailed deer to better understand proximate and ultimate causes of dispersal.
Proximate cues influence important features of dispersal behavior, including when dispersal occurs, how long it lasts, and the direction, straightness, and distance of the dispersal path. I tracked 229 radiomarked (VHF collars, n = 204; GPS collars, n = 25) juvenile female white-tailed deer in 4 study areas in Pennsylvania to evaluate dispersal behavior and to determine proximate cues that influence dispersal. I observed dispersal in all 4 study areas, with an overall dispersal rate of 11.8%. Female dispersal largely occurred at 1 year of age with an average dispersal date of 6 June, which coincides with the fawning season. Dispersal paths varied, but were generally non-linear (average straightness = 0.579), long distanced (average dispersal distance = 18.0 km), and prolonged (average duration = 355 hrs). Physical landscape features (i.e., roadways, rivers, residential areas) were important influences on changing dispersal path direction and influencing where dispersal terminated, however topography did not influence dispersal direction. Additionally, forays outside the natal range that did not result in dispersal were recorded in 52% of GPS-collared deer during the dispersal period. Our results suggest that dispersal behavior in female deer is influenced by both intra-specific social interactions, particularly during the fawning season, and physical landscape features.
The characteristics of dispersal behavior can provide insight into the ultimate causes and evolutionary strategies of dispersal. Hypotheses for the ultimate cause of dispersal suggest it is a beneficial strategy for the disperser because it reduces competition for local resources, reduces competition for breeding partners, and reduces the potential for inbreeding. Dispersal behavior in white-tailed deer predominantly occurs in 1-year-old males; however, females of the same age also disperse. The timing of female dispersal during fawning season and low…
Advisors/Committee Members: Duane R Diefenbach, Thesis Advisor/Co-Advisor, C Paola Ferreri, Thesis Advisor/Co-Advisor, Michael John Sheriff, Thesis Advisor/Co-Advisor, Christopher S Rosenberry, Thesis Advisor/Co-Advisor, Michael Gerard Messina, Thesis Advisor/Co-Advisor.
Subjects/Keywords: barriers; chronic wasting disease; disease spread; dispersal; foray; movement; Odocoileus virginianus; Pennsylvania; proximate causes; ultimate causes; white-tailed deer
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APA (6th Edition):
Lutz, C. L. (2015). Dispersal Behavior in Female White-tailed Deer. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/27216
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lutz, Clayton Lee. “Dispersal Behavior in Female White-tailed Deer.” 2015. Thesis, Penn State University. Accessed March 05, 2021.
https://submit-etda.libraries.psu.edu/catalog/27216.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lutz, Clayton Lee. “Dispersal Behavior in Female White-tailed Deer.” 2015. Web. 05 Mar 2021.
Vancouver:
Lutz CL. Dispersal Behavior in Female White-tailed Deer. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Mar 05].
Available from: https://submit-etda.libraries.psu.edu/catalog/27216.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lutz CL. Dispersal Behavior in Female White-tailed Deer. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/27216
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Humboldt State University
8.
Sanchez, Jessica N.
Spatial ecology of disease spread in the island fox.
Degree: 2012, Humboldt State University
URL: http://hdl.handle.net/2148/1045
► Diseases are potential threats to wildlife populations worldwide, and recent epidemics have demonstrated their far-reaching impacts. The spread of directly transmitted pathogens is influenced by…
(more)
▼ Diseases are potential threats to wildlife populations worldwide, and recent epidemics have demonstrated their far-reaching impacts. The
spread of directly transmitted pathogens is influenced by host contact rates, and host density can alter these contact rates by changing the spatial distribution of host home ranges. I explored how host density might affect the
spread of directly transmitted pathogens in Channel Island foxes (Urocyon littoralis) through changes in contact rates, home range size and overlap. I tracked 40 radio-collared foxes at four sites on San Clemente Island, which ranged in density from 2.8??1.28 to 42.8??9.43 foxes/km2. Thirty foxes wore collars that also contained proximity loggers. More overlap correlated with higher rates of contact between neighbors. Foxes at high densities had more neighbors with overlapping home ranges but not an increase in the amount of pair-wise overlap or contact between individual neighbors. I used these home range and contact data to parameterize a spatially explicit model of rabies and canine distemper
spread in island foxes. Modeled fox densities, home range sizes and degree of overlap, and contact rates approximated those measured on San Clemente Island. I examined how host density at the point of
disease introduction and different vaccination strategies (i.e., no vaccination, random vaccination, or firewall/core area vaccination) might affect
disease dynamics. In model simulations, canine distemper
spread quicker, infected more animals, and caused a greater reduction in the fox population than rabies due to differences in the length of the prepatent and infectious periods. The introduction of either pathogen to areas of high fox density resulted in more rapid transmission than if the pathogen was introduced at lower densities. Random vaccination was generally the more successful strategy for reducing the number of infected or dead animals from both diseases, and may be the preferable strategy for San Clemente Island. The model parameters with the greatest proportional effect on output were fox contact rates, virus transmissibility, background transmission rate, and the length of the prepatent and infectious periods. This study was the first time island fox contact rates were directly measured and compared to density and home range overlap, and it confirms that overlap is a reliable index of the amount of direct contact between island foxes. Model results can be used to advise conservation efforts aimed at preventing and responding to
disease outbreaks in island foxes.
Advisors/Committee Members: Hudgens, Brian.
Subjects/Keywords: Channel Islands; Urocyon littoralis; Modeling; Rabies; Canine distemper; Contact rates; Home range; Disease spread; Population density; Island fox
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APA (6th Edition):
Sanchez, J. N. (2012). Spatial ecology of disease spread in the island fox. (Thesis). Humboldt State University. Retrieved from http://hdl.handle.net/2148/1045
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sanchez, Jessica N. “Spatial ecology of disease spread in the island fox.” 2012. Thesis, Humboldt State University. Accessed March 05, 2021.
http://hdl.handle.net/2148/1045.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sanchez, Jessica N. “Spatial ecology of disease spread in the island fox.” 2012. Web. 05 Mar 2021.
Vancouver:
Sanchez JN. Spatial ecology of disease spread in the island fox. [Internet] [Thesis]. Humboldt State University; 2012. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2148/1045.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sanchez JN. Spatial ecology of disease spread in the island fox. [Thesis]. Humboldt State University; 2012. Available from: http://hdl.handle.net/2148/1045
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Arizona State University
9.
Padilla, Dustin.
Modeling the Role of Land-Use Change on the Spread of
Infectious Disease.
Degree: Applied Mathematics for the Life and Social
Sciences, 2020, Arizona State University
URL: http://repository.asu.edu/items/62713
Subjects/Keywords: Applied mathematics; Ecology; Epidemiology; edge effects; epidemiology; epizootic disease spread; land conversion; land-use change; zoonotic disease spread
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APA (6th Edition):
Padilla, D. (2020). Modeling the Role of Land-Use Change on the Spread of
Infectious Disease. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/62713
Chicago Manual of Style (16th Edition):
Padilla, Dustin. “Modeling the Role of Land-Use Change on the Spread of
Infectious Disease.” 2020. Doctoral Dissertation, Arizona State University. Accessed March 05, 2021.
http://repository.asu.edu/items/62713.
MLA Handbook (7th Edition):
Padilla, Dustin. “Modeling the Role of Land-Use Change on the Spread of
Infectious Disease.” 2020. Web. 05 Mar 2021.
Vancouver:
Padilla D. Modeling the Role of Land-Use Change on the Spread of
Infectious Disease. [Internet] [Doctoral dissertation]. Arizona State University; 2020. [cited 2021 Mar 05].
Available from: http://repository.asu.edu/items/62713.
Council of Science Editors:
Padilla D. Modeling the Role of Land-Use Change on the Spread of
Infectious Disease. [Doctoral Dissertation]. Arizona State University; 2020. Available from: http://repository.asu.edu/items/62713
Swedish University of Agricultural Sciences
10.
Widgren, Stefan.
Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.
Degree: 2016, Swedish University of Agricultural Sciences
URL: https://pub.epsilon.slu.se/13821/
► Verotoxigenic Escherichia coli O157:H7 (VTEC O157) is an important zoonotic pathogen capable of causing infections in humans, sometimes with severe symptoms such as hemorrhagic colitis…
(more)
▼ Verotoxigenic Escherichia coli O157:H7 (VTEC O157) is an important zoonotic pathogen capable of causing infections in humans, sometimes with severe symptoms such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). Cattle are considered to be the main reservoir of the bacterium. In this thesis, sampling strategies to detect VTEC O157 in a cattle herd, risk factors for the introduction and the spread of VTEC O157 in Swedish cattle herds, as well as options for control, are studied. A spatial data-driven stochastic model was developed to explore the spread of VTEC O157 by livestock movements and local transmission among proximal holdings in the complete Swedish cattle population. Overshoe sampling alone or in combination with dust and/or pooled pat sampling were established to be reliable for identifying cattle herds with animals shedding VTEC O157. Results from field studies and computer simulations show that animal movements and local spread are important for the transmission of VTEC O157 in the Swedish cattle population. However, simulated control measures based on reducing the between-herd VTEC O157 transmission by animal movements and local spread, had marginal effect in decreasing the prevalence. On the other hand, simulated control measures based on reducing the shedding and susceptibility, efficiently decreased the prevalence of VTEC O157 in the Swedish cattle population.
Subjects/Keywords: escherichia coli; zoonoses; cattle; herds; epidemiology; data analysis; mathematical models; simulation; disease control; sweden; Data-driven disease spread modelling; Computer simulations; Epidemiology; VTEC O157; Control; Zoonosis
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APA (6th Edition):
Widgren, S. (2016). Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. (Doctoral Dissertation). Swedish University of Agricultural Sciences. Retrieved from https://pub.epsilon.slu.se/13821/
Chicago Manual of Style (16th Edition):
Widgren, Stefan. “Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.” 2016. Doctoral Dissertation, Swedish University of Agricultural Sciences. Accessed March 05, 2021.
https://pub.epsilon.slu.se/13821/.
MLA Handbook (7th Edition):
Widgren, Stefan. “Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.” 2016. Web. 05 Mar 2021.
Vancouver:
Widgren S. Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. [Internet] [Doctoral dissertation]. Swedish University of Agricultural Sciences; 2016. [cited 2021 Mar 05].
Available from: https://pub.epsilon.slu.se/13821/.
Council of Science Editors:
Widgren S. Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. [Doctoral Dissertation]. Swedish University of Agricultural Sciences; 2016. Available from: https://pub.epsilon.slu.se/13821/
Swedish University of Agricultural Sciences
11.
Widgren, Stefan.
Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.
Degree: 2016, Swedish University of Agricultural Sciences
URL: https://pub.epsilon.slu.se/13821/
► Verotoxigenic Escherichia coli O157:H7 (VTEC O157) is an important zoonotic pathogen capable of causing infections in humans, sometimes with severe symptoms such as hemorrhagic colitis…
(more)
▼ Verotoxigenic Escherichia coli O157:H7 (VTEC O157) is an important zoonotic pathogen capable of causing infections in humans, sometimes with severe symptoms such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). Cattle are considered to be the main reservoir of the bacterium. In this thesis, sampling strategies to detect VTEC O157 in a cattle herd, risk factors for the introduction and the spread of VTEC O157 in Swedish cattle herds, as well as options for control, are studied. A spatial data-driven stochastic model was developed to explore the spread of VTEC O157 by livestock movements and local transmission among proximal holdings in the complete Swedish cattle population. Overshoe sampling alone or in combination with dust and/or pooled pat sampling were established to be reliable for identifying cattle herds with animals shedding VTEC O157. Results from field studies and computer simulations show that animal movements and local spread are important for the transmission of VTEC O157 in the Swedish cattle population. However, simulated control measures based on reducing the between-herd VTEC O157 transmission by animal movements and local spread, had marginal effect in decreasing the prevalence. On the other hand, simulated control measures based on reducing the shedding and susceptibility, efficiently decreased the prevalence of VTEC O157 in the Swedish cattle population.
Subjects/Keywords: escherichia coli; zoonoses; cattle; herds; epidemiology; data analysis; mathematical models; simulation; disease control; sweden; Data-driven disease spread modelling; Computer simulations; Epidemiology; VTEC O157; Control; Zoonosis
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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Manager
APA (6th Edition):
Widgren, S. (2016). Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. (Doctoral Dissertation). Swedish University of Agricultural Sciences. Retrieved from https://pub.epsilon.slu.se/13821/
Chicago Manual of Style (16th Edition):
Widgren, Stefan. “Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.” 2016. Doctoral Dissertation, Swedish University of Agricultural Sciences. Accessed March 05, 2021.
https://pub.epsilon.slu.se/13821/.
MLA Handbook (7th Edition):
Widgren, Stefan. “Studies on verotoxigenic Escherichia coli O157 in Swedish cattle.” 2016. Web. 05 Mar 2021.
Vancouver:
Widgren S. Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. [Internet] [Doctoral dissertation]. Swedish University of Agricultural Sciences; 2016. [cited 2021 Mar 05].
Available from: https://pub.epsilon.slu.se/13821/.
Council of Science Editors:
Widgren S. Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. [Doctoral Dissertation]. Swedish University of Agricultural Sciences; 2016. Available from: https://pub.epsilon.slu.se/13821/
Humboldt State University
12.
Deshais, Janelle.
Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models.
Degree: MS, Natural Resources: Forestry, 2010, Humboldt State University
URL: http://hdl.handle.net/2148/659
► Phytophthora ramorum, an aggressive introduced plant pathogen, has caused the death of several million tanoak (Lithocarpus densiflorus) and oak (Quercus spp.) trees throughout coastal forests…
(more)
▼ Phytophthora ramorum, an aggressive introduced plant pathogen, has caused the death of several million tanoak (Lithocarpus densiflorus) and oak (Quercus spp.) trees throughout coastal forests of California and Oregon. In the United States, P. ramorum infections occur in 14 contiguous coastal California counties, from Monterey to Humboldt, and in Curry County, Oregon. Currently, P. ramorum has not been detected in the forests of Redwood National and State Parks (RNSP), however, the pathogen occurs in close proximity. An infestation in Curry County, Oregon is 17 km north of RNSP???s Jedediah Smith State Park, and a recent detection near Redwood Valley (Humboldt County, California) is less than 8 km southeast of the Parks??? southern border. This closeness is concerning because much of RNSP is vulnerable to P. ramorum infestation. Using Maxent, a niche-based modeling program, I determined that 60% of RNSP has the presence of at least one key pathogen-transmission species: California bay (Umbellularia californica), tanoak, and Pacific rhododendron (Rhododendron macrophyllum). Tanoak, which is also highly susceptible to P. ramorum-induced mortality, occurred in 47% of RNSP. All species??? models showed sufficient sensitivity and accuracy to create reliable distribution maps at 30 m x 30 m resolution. These data will be used in future efforts to predict potential P. ramorum
disease spread throughout the Parks.
Advisors/Committee Members: Stuart, John.
Subjects/Keywords: Phytophthora ramorum; Sudden oak death; Ecological niche model; Maxent; Disease spread
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APA (6th Edition):
Deshais, J. (2010). Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models. (Masters Thesis). Humboldt State University. Retrieved from http://hdl.handle.net/2148/659
Chicago Manual of Style (16th Edition):
Deshais, Janelle. “Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models.” 2010. Masters Thesis, Humboldt State University. Accessed March 05, 2021.
http://hdl.handle.net/2148/659.
MLA Handbook (7th Edition):
Deshais, Janelle. “Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models.” 2010. Web. 05 Mar 2021.
Vancouver:
Deshais J. Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models. [Internet] [Masters thesis]. Humboldt State University; 2010. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2148/659.
Council of Science Editors:
Deshais J. Predicting sudden oak death transmission hosts in Redwood National and State Parks using ecological niche models. [Masters Thesis]. Humboldt State University; 2010. Available from: http://hdl.handle.net/2148/659
Kansas State University
13.
Carlyle, Kyle R.
Optimizing
quarantine regions through graph theory and simulation.
Degree: MS, Department of Industrial &
Manufacturing Systems
Engineering, 2009, Kansas State University
URL: http://hdl.handle.net/2097/1472
► Epidemics have been modeled mathematically as a way to safely understand them. For many of these mathematical models, the underlying assumptions they make provide excellent…
(more)
▼ Epidemics have been modeled mathematically as a way to
safely understand them. For many of these mathematical models, the
underlying assumptions they make provide excellent mathematical
results, but are unrealistic for practical use. This research
branches out from previous work by providing a model of the
spread
of infectious diseases and a model of quarantining this
disease
without the limiting assumptions of previous research.
One of the
main results of this thesis was the development of a core
simulation that rapidly simulates the
spread of an epidemic on a
contact network. This simulation can be easily adapted to any
disease through the adjustment of many parameters.
This research
provides the first definition for a quarantine cut and an
ellipsoidal geographic network. This thesis uses the ellipsoidal
geographic network to determine what is, and what is not, a
feasible quarantine region. The quarantine cut is a new approach to
partitioning quarantined and saved individuals in an optimized way.
To achieve an optimal quarantine cut, an integer program was
developed. Although this integer program runs in polynomial time,
the preparation required to execute this algorithm is unrealistic
in a
disease outbreak scenario. To provide implementable results, a
heuristic and some general theory are provided. In a study, the
heuristic performed within 10% of the optimal quarantine cut, which
shows that the theory developed in this thesis can be successfully
used in a
disease outbreak scenario.
Advisors/Committee Members: Todd W. Easton.
Subjects/Keywords: Quarantine;
Optimizing;
Simulation;
Disease;
Spread; Engineering, Industrial (0546); Operations Research (0796)
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APA (6th Edition):
Carlyle, K. R. (2009). Optimizing
quarantine regions through graph theory and simulation. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/1472
Chicago Manual of Style (16th Edition):
Carlyle, Kyle R. “Optimizing
quarantine regions through graph theory and simulation.” 2009. Masters Thesis, Kansas State University. Accessed March 05, 2021.
http://hdl.handle.net/2097/1472.
MLA Handbook (7th Edition):
Carlyle, Kyle R. “Optimizing
quarantine regions through graph theory and simulation.” 2009. Web. 05 Mar 2021.
Vancouver:
Carlyle KR. Optimizing
quarantine regions through graph theory and simulation. [Internet] [Masters thesis]. Kansas State University; 2009. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2097/1472.
Council of Science Editors:
Carlyle KR. Optimizing
quarantine regions through graph theory and simulation. [Masters Thesis]. Kansas State University; 2009. Available from: http://hdl.handle.net/2097/1472
University of Edinburgh
14.
Bessell, Paul R.
Spatial epidemiology of Foot and Mouth Disease in Great Britain.
Degree: PhD, 2009, University of Edinburgh
URL: http://hdl.handle.net/1842/4831
► During 2007 the UK experienced outbreaks of three notifiable exotic livestock diseases; Foot and Mouth Disease (FMD), Highly Pathogenic Avian Influenza (HPAI) and bluetongue. Large…
(more)
▼ During 2007 the UK experienced outbreaks of three notifiable exotic livestock diseases; Foot and Mouth Disease (FMD), Highly Pathogenic Avian Influenza (HPAI) and bluetongue. Large epidemics of any of these diseases would have a serious impact on animal welfare, farming, food production and the economy. In light of this, understanding holdings which are most likely to acquire and spread infection and being able to identify areas at higher risk of an epidemic is valuable when preparing for and managing an epidemic. This thesis uses a spatial epidemiological framework and the detailed disease and demographic data from the 2001 Great Britain (GB) FMD epidemic to develop static models of the risk of FMD susceptibility and transmission. These models are used to develop maps of FMD risk. These methods are then applied to the outbreak of FMD in 2007. The inputs for this analysis comprised a set of data relating to the farms diagnosed with FMD and farms culled as part of the disease control measures. The cleaning of these data is described and data which were estimated relating to dates of infection and putative sources of infection are evaluated. The distribution of farm holdings and animals is taken from the June 2000 GB agricultural census, off-fields of farms in the agricultural census are recorded in other datasets and these have been identified and linked to census holdings. A model of holding level susceptibility is developed using both farm level variables and measures of animal numbers in the locality of the holding as well as the distance to the nearest farm infected before the ban on animal movements (seeds). The overall fit of the model was very good with an area under the Receiver Operator Characteristic (ROC) curve of 0.91. A further model was developed to describe the risk of FMD transmission. However, due to incompleteness of transmission data, this was a model of the risk of finding a subsequent Infected Premises (IP) within 3km of an IP. Risk factors were a combination of holding level variables and locality measures as well as data relevant to the infection, such as infectious period and the species initially infected. The area under the ROC curve for this model was 0.71, which is regarded as an acceptable fit. Geographical barriers to FMD transmission were investigated using a case-control methodology, linear barriers comprising rivers and railways had a significant protective effect with respect to disease transmission (odds ratio = 0.54, 95% CIs = 0.30,0.96, p=0.038). Modelled values for the transmission and susceptibility models were transformed to a raster surface in ESRI ArcMap for both the disease as it was seeded in the 2001 epidemic and a non-specific background risk surface independent of the distribution of seeds. A risk map generated for the outbreak of FMD in Surrey in August 2007 suggested that there was little risk of a large outbreak in Surrey. Potential disease introductions through livestock movements from Surrey into Scotland were identified and these suggested that if the disease were…
Subjects/Keywords: 636.089; spatial epidemiology; livestock disease; Foot and Mouth Disease; infection spread; susceptibility and transmission
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APA (6th Edition):
Bessell, P. R. (2009). Spatial epidemiology of Foot and Mouth Disease in Great Britain. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4831
Chicago Manual of Style (16th Edition):
Bessell, Paul R. “Spatial epidemiology of Foot and Mouth Disease in Great Britain.” 2009. Doctoral Dissertation, University of Edinburgh. Accessed March 05, 2021.
http://hdl.handle.net/1842/4831.
MLA Handbook (7th Edition):
Bessell, Paul R. “Spatial epidemiology of Foot and Mouth Disease in Great Britain.” 2009. Web. 05 Mar 2021.
Vancouver:
Bessell PR. Spatial epidemiology of Foot and Mouth Disease in Great Britain. [Internet] [Doctoral dissertation]. University of Edinburgh; 2009. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/1842/4831.
Council of Science Editors:
Bessell PR. Spatial epidemiology of Foot and Mouth Disease in Great Britain. [Doctoral Dissertation]. University of Edinburgh; 2009. Available from: http://hdl.handle.net/1842/4831
Kansas State University
15.
Montazeri Shahtori, Narges.
Quantifying
the impact of contact tracing on ebola spreading.
Degree: MS, Department of Electrical and
Computer Engineering, 2016, Kansas State University
URL: http://hdl.handle.net/2097/34540
► Recent experience of Ebola outbreak of 2014 highlighted the importance of immediate response to impede Ebola transmission at its very early stage. To this aim,…
(more)
▼ Recent experience of Ebola outbreak of 2014
highlighted the importance of immediate response to impede Ebola
transmission at its very early stage. To this aim, efficient and
effective allocation of limited resources is crucial. Among
standard interventions is the practice of following up with
physical contacts of individuals diagnosed with Ebola virus
disease
– known as contact tracing. In an effort to objectively understand
the effect of possible contact tracing protocols, we explicitly
develop a model of Ebola transmission incorporating contact
tracing. Our modeling framework has several features to suit
early–stage Ebola transmission: 1) the network model is
patient–centric because when number of infected cases are small
only the myopic networks of infected individuals matter and the
rest of possible social contacts are irrelevant, 2) the Ebola
disease model is individual–based and stochastic because at the
early stages of
spread, random fluctuations are significant and
must be captured appropriately, 3) the contact tracing model is
parameterizable to analyze the impact of critical aspects of
contact tracing protocols.
Notably, we propose an activity driven
network approach to contact tracing, and develop a Monte-Carlo
method to compute the basic reproductive number of the
disease
spread in different scenarios. Exhaustive simulation experiments
suggest that while contact tracing is important in stopping the
Ebola
spread, it does not need to be done too urgently. This result
is due to rather long incubation period of Ebola
disease infection.
However, immediate hospitalization of infected cases is crucial and
requires the most attention and resource allocation.
Moreover, to
investigate the impact of mitigation strategies in the 2014 Ebola
outbreak, we consider reported data in Guinea, one the three West
Africa countries that had experienced the Ebola virus
disease
outbreak. We formulate a multivariate sequential Monte Carlo filter
that utilizes mechanistic models for Ebola virus propagation to
simultaneously estimate the
disease progression states and the
model parameters according to reported incidence data streams. This
method has the advantage of performing the inference online as the
new data becomes available and estimating the evolution of the
basic reproductive ratio R₀(t) throughout the Ebola outbreak. Our
analysis identifies a peak in the basic reproductive ratio close to
the time of Ebola cases reports in Europe and the USA.
Advisors/Committee Members: Faryad Darabi Sahneh.
Subjects/Keywords: Infectious
diseases spread; Ebola virus
disease;
Mathematical modeling of infectious disease; State
estimation; Monte Carlo
methods; Sequential
Monte Carlo method;
Reproductive ratio; Basic
reproductive number; Temporal
network;
Heterogeneous network; Contact
tracing;
Sensitivity;
Specificity
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APA ·
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MLA ·
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Manager
APA (6th Edition):
Montazeri Shahtori, N. (2016). Quantifying
the impact of contact tracing on ebola spreading. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/34540
Chicago Manual of Style (16th Edition):
Montazeri Shahtori, Narges. “Quantifying
the impact of contact tracing on ebola spreading.” 2016. Masters Thesis, Kansas State University. Accessed March 05, 2021.
http://hdl.handle.net/2097/34540.
MLA Handbook (7th Edition):
Montazeri Shahtori, Narges. “Quantifying
the impact of contact tracing on ebola spreading.” 2016. Web. 05 Mar 2021.
Vancouver:
Montazeri Shahtori N. Quantifying
the impact of contact tracing on ebola spreading. [Internet] [Masters thesis]. Kansas State University; 2016. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/2097/34540.
Council of Science Editors:
Montazeri Shahtori N. Quantifying
the impact of contact tracing on ebola spreading. [Masters Thesis]. Kansas State University; 2016. Available from: http://hdl.handle.net/2097/34540
16.
Werkman, Marleen.
Network models of live fish movements and disease spread in Scottish aquaculture.
Degree: PhD, 2012, University of Stirling
URL: http://hdl.handle.net/1893/6510
► The Scottish salmon industry is facing challenges in the control of aquatic infectious disease, as is the case in other countries such as Chile and…
(more)
▼ The Scottish salmon industry is facing challenges in the control of aquatic infectious disease, as is the case in other countries such as Chile and Norway. Disease outbreaks can have an enormous economic impact and possibly affect wild fish populations. Disease transmission in an aquatic environment is complex and there are several transmission routes (vertical transmission, natural reservoirs, hydrodynamic transmission and long-distance movements). Effective control methods such as vaccines are not available in all cases and therefore disease prevention remains a priority.
In livestock, epidemiological network models have been proven to be a highly useful tool to investigate the role of different transmission routes on the course of epidemics and have the potential to provide the same utility for aquatic networks. Understanding the complex contact network will result in more effective disease prevention, surveillance systems and control strategies. The aim of this thesis was to investigate the Scottish live fish movement network and its consequences for pathogen transmission between farms in order to develop and optimize control strategies for epidemics.
The main objective of chapter 3 was to investigate the effect of different fallowing strategies on the spread of diseases with different transmission properties. A network model was constructed that included both local transmission and long-distance transmission. The basic structure of this network was a ring model where neighbours within a management area could infect each other and non-local transmission occurred at random. The results showed that when long-distance transmission was under reasonable control in comparison with local transmission risk, synchronized fallowing at the management area level was potentially a highly effective tool in the control of infectious diseases.
Chapter 4 presents a detailed description of the number of live fish movements and their timing for Atlantic salmon (Salmo salar) in Scottish aquaculture. For this, movement records from 2002 to 2004 were provided by Marine Scotland, Aberdeen. Salmon are anadromous and have a freshwater (FW) and seawater phase (SW). Scottish live fish movements can be divided in FW-FW, FW-SW, SW-SW, SW-FW and “other” movements. The latter are mainly movements from and to research sites. This study showed that the contact structure and timing of live fish movements are seasonal and differ largely between production phases. Disease control measures should take these differences into account to optimize their strategies.
In chapter 4, live fish movements were shown to be seasonal; therefore in chapter 5 the main aim was to quantify the effects of seasonality of live fish movements on the course of epidemics. The results showed that the sequence of salmon movements is important for the course of an epidemic. Seasonality is important when local transmission is higher than 0.05 per contact per week and when the movements are not clustered and when movements do not occur in a specific order based on the…
Subjects/Keywords: Epidemiology; Aquaculture; Live fish movements; Disease spread; Salmon industry Scotland; Fishes Diseases
…potential disease
spread. Prev. Vet. Med. 80, 143-165.
Bigras-Poulin, M., Thompson, R.A., Chriel… …patterns as an evaluation of risk
potential for disease spread. Prev. Vet. Med. 76, 11-39… …147!
6.2.2. Disease transmission… …150!
6.3.2. Disease data… …describe the spread of pathogens between Scottish marine fish farms. ..................... 60…
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Werkman, M. (2012). Network models of live fish movements and disease spread in Scottish aquaculture. (Doctoral Dissertation). University of Stirling. Retrieved from http://hdl.handle.net/1893/6510
Chicago Manual of Style (16th Edition):
Werkman, Marleen. “Network models of live fish movements and disease spread in Scottish aquaculture.” 2012. Doctoral Dissertation, University of Stirling. Accessed March 05, 2021.
http://hdl.handle.net/1893/6510.
MLA Handbook (7th Edition):
Werkman, Marleen. “Network models of live fish movements and disease spread in Scottish aquaculture.” 2012. Web. 05 Mar 2021.
Vancouver:
Werkman M. Network models of live fish movements and disease spread in Scottish aquaculture. [Internet] [Doctoral dissertation]. University of Stirling; 2012. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/1893/6510.
Council of Science Editors:
Werkman M. Network models of live fish movements and disease spread in Scottish aquaculture. [Doctoral Dissertation]. University of Stirling; 2012. Available from: http://hdl.handle.net/1893/6510
17.
van der Burgh, Hannelore Kristine|info:eu-repo/dai/nl/413641066.
Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective.
Degree: 2020, University Utrecht
URL: https://dspace.library.uu.nl/handle/1874/390139
;
URN:NBN:NL:UI:10-1874-390139
;
urn:isbn:978-90-393-7244-9
;
URN:NBN:NL:UI:10-1874-390139
;
https://dspace.library.uu.nl/handle/1874/390139
► Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease and is characterized by upper and lower motor neuron involvement. ALS is a heterogeneous disease in…
(more)
▼ Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative
disease and is characterized by upper and lower motor neuron involvement. ALS is a heterogeneous
disease in terms of
disease onset and progression, making it difficult to determine the cause of the
disease. Identifying subgroups within the ALS population and elucidating their corresponding neuroimaging patterns may help as a biomarker to monitor
disease progression and possible treatment effects in clinical trials. This thesis combines different perspectives of neuroimaging, network science and machine learning to shine light on
disease patterns of gray and white matter involvement in the brain and spinal cord of patients within the ALS population. Patients with ALS, divided into subgroups based on clinical or genetic characteristics, display various degrees of gray and white matter involvement. From these results, four different MRI-detectable brain patterns could be distinguished over time. White matter degeneration seems to occur early in the
disease process, followed by gray matter involvement over time. For patients with a C9orf72 gene mutation, the opposite might be true as these patients display thinner cortex throughout the brain at baseline. Not only patients but also asymptomatic family members with this mutation show changes in the brain compared to family members without the mutation. The relative cortical thinning is associated with the gene expression of C9orf72, which suggests a regional vulnerability of brain areas to become affected by ALS. Besides brain alterations, ALS also affects the motor neurons in the spinal cord. Thinning of the upper cervical spinal cord does not occur only in patients with ALS, but throughout the motor neuron
disease spectrum. Longitudinal cervical spinal cord measurements were progressive over time for ALS and showed a significant relationship with
disease severity. Therefore, neuroimaging of the spinal cord may possibly be an additional measure for diagnosis or
disease progression outside the brain. Simulating
disease spread can provide insight in potential
disease mechanisms. By applying a random walker model on the white matter network,
disease spread according to histologically defined neuropathology staging was simulated. Simulated aggregation levels of pTDP-43 proteins correlated with empirical impairment found at follow-up, both for the total group and individual patients. Hence, early-stage white matter alterations define subsequent pathology. Characterization of network metrics has the potential to elucidate affected organization in the connectome (i.e. white matter network), reflecting patterns of neurodegeneration
spread across the white matter tracts in the brain. The findings showed that the nodal network metrics based on shortest paths in the network are important network measures in the understanding of
disease effects. Survival classes of patients may be predicted by using supervised deep learning techniques on clinical and neuroimaging variables. The combination of modalities improves…
Advisors/Committee Members: van den Berg, Leonard, van den Heuvel, Martijn, Meier, Jil.
Subjects/Keywords: Amyotrophic lateral sclerosis; neuroimaging; network science; machine learning; disease spread; survival prediction; spinal cord; gray matter; white matter; connectome
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APA (6th Edition):
van der Burgh, H. K. (2020). Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/390139 ; URN:NBN:NL:UI:10-1874-390139 ; urn:isbn:978-90-393-7244-9 ; URN:NBN:NL:UI:10-1874-390139 ; https://dspace.library.uu.nl/handle/1874/390139
Chicago Manual of Style (16th Edition):
van der Burgh, Hannelore Kristine|info:eu-repo/dai/nl/413641066. “Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective.” 2020. Doctoral Dissertation, University Utrecht. Accessed March 05, 2021.
https://dspace.library.uu.nl/handle/1874/390139 ; URN:NBN:NL:UI:10-1874-390139 ; urn:isbn:978-90-393-7244-9 ; URN:NBN:NL:UI:10-1874-390139 ; https://dspace.library.uu.nl/handle/1874/390139.
MLA Handbook (7th Edition):
van der Burgh, Hannelore Kristine|info:eu-repo/dai/nl/413641066. “Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective.” 2020. Web. 05 Mar 2021.
Vancouver:
van der Burgh HK. Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective. [Internet] [Doctoral dissertation]. University Utrecht; 2020. [cited 2021 Mar 05].
Available from: https://dspace.library.uu.nl/handle/1874/390139 ; URN:NBN:NL:UI:10-1874-390139 ; urn:isbn:978-90-393-7244-9 ; URN:NBN:NL:UI:10-1874-390139 ; https://dspace.library.uu.nl/handle/1874/390139.
Council of Science Editors:
van der Burgh HK. Shining light on patterns in ALS : from a neuroimaging, network science and machine learning perspective. [Doctoral Dissertation]. University Utrecht; 2020. Available from: https://dspace.library.uu.nl/handle/1874/390139 ; URN:NBN:NL:UI:10-1874-390139 ; urn:isbn:978-90-393-7244-9 ; URN:NBN:NL:UI:10-1874-390139 ; https://dspace.library.uu.nl/handle/1874/390139
18.
Lee, Mi Lim.
Bio-surveillance: detection and mitigation of disease outbreak.
Degree: PhD, Industrial and Systems Engineering, 2013, Georgia Tech
URL: http://hdl.handle.net/1853/50297
► In spite of the remarkable development of modern medical treatment and technology, the threat of pandemic diseases such as anthrax, cholera, and SARS has not…
(more)
▼ In spite of the remarkable development of modern medical treatment and technology, the threat of pandemic diseases such as anthrax, cholera, and SARS has not disappeared. As a part of emerging healthcare decision problems, many researchers have studied how to detect and contain
disease outbreaks, and our research is aligned with this trend. This thesis mainly consists of two parts: epidemic simulation modeling for effective intervention strategies and spatiotemporal monitoring for outbreak detection.
We developed a stochastic epidemic simulation model of a pandemic influenza virus (H1N1) to test possible interventions within a structured population. The possible interventions — such as vaccination, antiviral treatment, household prophylaxis, school closure and social distancing — are investigated in a large number of scenarios, including delays in vaccine delivery and low and moderate efficacy of the vaccine.
Since timely and accurate detection of a
disease outbreak is crucial in terms of preparation for emergencies in healthcare and biosurveillance, we suggest two spatiotemporal monitoring charts, namely, the SMCUSUM and RMCUSUM charts, to detect increases in the rate or count of
disease incidents. Our research includes convenient methods to approximate the control limits of the charts. An analytical control limit approximation method for the SMCUSUM chart performs well under certain conditions on the data distribution and monitoring range. Another control limit approximation method for the RMCUSUM chart provides robust performance to various monitoring range, spatial correlation structures, and data distributions without intensive modeling of the underlying process.
Advisors/Committee Members: Kim, Seong-Hee (advisor), Tsui, Kwok-Leung (advisor), Goldsman, David M. (advisor), Andradottir, Sigrun (committee member), Vengazhiyil, Roshan (committee member).
Subjects/Keywords: Biosurveillance; Disease outbreaks; Disease spread simulation; CUSUM chart; Detection; Mitigation; Epidemics; Public health surveillance; Environmental monitoring; Communicable diseases
…detect and contain disease outbreaks, and our research is aligned
with this trend. This thesis… …of the vaccine.
Since timely and accurate detection of a disease outbreak is crucial in… …rate or count of disease incidents. Our research includes
convenient methods to approximate… …undertaken on the design and performance of disease outbreak
surveillance systems and mitigation… …analyzing and estimating the spread of
past and future pandemics.
Epidemic simulation models that…
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APA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Lee, M. L. (2013). Bio-surveillance: detection and mitigation of disease outbreak. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/50297
Chicago Manual of Style (16th Edition):
Lee, Mi Lim. “Bio-surveillance: detection and mitigation of disease outbreak.” 2013. Doctoral Dissertation, Georgia Tech. Accessed March 05, 2021.
http://hdl.handle.net/1853/50297.
MLA Handbook (7th Edition):
Lee, Mi Lim. “Bio-surveillance: detection and mitigation of disease outbreak.” 2013. Web. 05 Mar 2021.
Vancouver:
Lee ML. Bio-surveillance: detection and mitigation of disease outbreak. [Internet] [Doctoral dissertation]. Georgia Tech; 2013. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/1853/50297.
Council of Science Editors:
Lee ML. Bio-surveillance: detection and mitigation of disease outbreak. [Doctoral Dissertation]. Georgia Tech; 2013. Available from: http://hdl.handle.net/1853/50297
19.
Schaik, van, G.
Risk and economics of disease introduction into dairy farms.
Degree: 2000, Agricultural University
URL: http://library.wur.nl/WebQuery/wurpubs/66750
;
urn:nbn:nl:ui:32-66750
;
urn:nbn:nl:ui:32-66750
;
http://library.wur.nl/WebQuery/wurpubs/66750
► A well closed farming system will enhance the success of disease eradication programs, because introduction or reintroduction of infectious diseases are less likely. The…
(more)
▼ A well closed farming system will enhance the success of
disease eradication programs, because introduction or reintroduction of infectious diseases are less likely. The economic implications of a more closed farming system will not always been obvious for farmers. The management decisions need to be made for different parts of the farm and are farm-specific. The objective of the study was to obtain input for and to develop an on-farm decisions support model to calculate the economic consequences of a more closed farming system. The input was based on IBR, since there were numerous data on this
disease, but a more closed farming system will prevent introduction of other diseases as well (i.e. Bovine Virus Diarrhoea Virus (BVDV), Leptospira interrogans serovar hardjo
(L. hardjo) , and Salmonella enterica subsp. enterica serotype Dublin
(S. dublin) ). Direct animal contacts such as purchase of cattle, participating in cattle shows, and cattle that breach or escape and mingle with other cattle were found to be important risk factors for introduction of Bovine Herpesvirus type 1 (BHV1). Furthermore, the use of protective farm clothing was found to be an important preventive factor. The effect of a BHV1 outbreak on milk production was estimated with a random effect model. An outbreak of BHV1 on a BHV1-free farm, caused limited milk production losses of on average 39 kg per cow during the outbreak, but the variability was high (95% CI 1-77 kg). Nine percent of Dutch BHV1-free dairy farms that were also at risk for BVDV,
L. hardjo and/or
S. dublin had one introduction per year of one of these four diseases. All these results were incorporated in the static, deterministic economic model. The management measures to reduce the probability of introduction of BHV1, the costs of these measures, and the risk reduction of these measures were obtained from other sources. Costs were calculated by using partial budgeting. The model was verified and partly validated and a sensitivity analysis was carried out to obtain insight into the model behaviour. A hypothetical 55-cow dairy farm that refrained from purchasing cattle, provided protective clothing to professional visitors and a temporary worker, and placed a double fence on six ha. of land to prevent over the fence contacts, had to spend Dfl. 4495 in five years. The probability of
disease introduction was decreased by 74%. The avoided losses for
disease introduction amounted to Dfl. 7033 over five years. The benefit of becoming more closed for this hypothetical farm was Dfl. 2538. The implementation of a more closed system will be profitable for most farms. The profitability will increase when a farm is at risk for more diseases, but will decrease when farms are limited in their facilities to rear replacement heifers or when a large amount of pasture adjoins pasture of other cattle farms.
Advisors/Committee Members: A.A. Dijkhuizen, Y.H. Schukken, M. Nielen, G. Benedictus.
Subjects/Keywords: rundvee; melkveebedrijven; ziekten; economie; ziektedistributie; spreiding; ziektebestrijding; risicovermindering; Infectieziekten; cattle; dairy farms; diseases; economics; disease distribution; spread; disease control; risk reduction; Infectious Diseases
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Schaik, van, G. (2000). Risk and economics of disease introduction into dairy farms. (Doctoral Dissertation). Agricultural University. Retrieved from http://library.wur.nl/WebQuery/wurpubs/66750 ; urn:nbn:nl:ui:32-66750 ; urn:nbn:nl:ui:32-66750 ; http://library.wur.nl/WebQuery/wurpubs/66750
Chicago Manual of Style (16th Edition):
Schaik, van, G. “Risk and economics of disease introduction into dairy farms.” 2000. Doctoral Dissertation, Agricultural University. Accessed March 05, 2021.
http://library.wur.nl/WebQuery/wurpubs/66750 ; urn:nbn:nl:ui:32-66750 ; urn:nbn:nl:ui:32-66750 ; http://library.wur.nl/WebQuery/wurpubs/66750.
MLA Handbook (7th Edition):
Schaik, van, G. “Risk and economics of disease introduction into dairy farms.” 2000. Web. 05 Mar 2021.
Vancouver:
Schaik, van G. Risk and economics of disease introduction into dairy farms. [Internet] [Doctoral dissertation]. Agricultural University; 2000. [cited 2021 Mar 05].
Available from: http://library.wur.nl/WebQuery/wurpubs/66750 ; urn:nbn:nl:ui:32-66750 ; urn:nbn:nl:ui:32-66750 ; http://library.wur.nl/WebQuery/wurpubs/66750.
Council of Science Editors:
Schaik, van G. Risk and economics of disease introduction into dairy farms. [Doctoral Dissertation]. Agricultural University; 2000. Available from: http://library.wur.nl/WebQuery/wurpubs/66750 ; urn:nbn:nl:ui:32-66750 ; urn:nbn:nl:ui:32-66750 ; http://library.wur.nl/WebQuery/wurpubs/66750
Queensland University of Technology
20.
Hafner, Gregory.
Replication of banana bunchy top virus : mechanisms and interference.
Degree: 1998, Queensland University of Technology
URL: http://eprints.qut.edu.au/36970/
Subjects/Keywords: Banana bunchy top disease; Bananas Diseases and pests; banana; bunchy top; virus; disease; transmission; movement; systemic spread; Pentalonia nigronervosa; genome; strand-initiation; self-priming; primer; Rep; replication; initiator; protein; nicking; joining; ribozyme; antisense; resistance; Musa; thesis; doctoral
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Hafner, G. (1998). Replication of banana bunchy top virus : mechanisms and interference. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/36970/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hafner, Gregory. “Replication of banana bunchy top virus : mechanisms and interference.” 1998. Thesis, Queensland University of Technology. Accessed March 05, 2021.
http://eprints.qut.edu.au/36970/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hafner, Gregory. “Replication of banana bunchy top virus : mechanisms and interference.” 1998. Web. 05 Mar 2021.
Vancouver:
Hafner G. Replication of banana bunchy top virus : mechanisms and interference. [Internet] [Thesis]. Queensland University of Technology; 1998. [cited 2021 Mar 05].
Available from: http://eprints.qut.edu.au/36970/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hafner G. Replication of banana bunchy top virus : mechanisms and interference. [Thesis]. Queensland University of Technology; 1998. Available from: http://eprints.qut.edu.au/36970/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
N'Guessan, R.
Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay.
Degree: 2009, NARCIS
URL: http://library.wur.nl/WebQuery/wurpubs/384855
;
urn:nbn:nl:ui:32-384855
;
urn:nbn:nl:ui:32-384855
;
http://library.wur.nl/WebQuery/wurpubs/384855
► There is a current policy to eliminate malaria in the African continent. Pyrethroid-incorporated Long Lasting Insecticidal Nets (LLINs) and/or Indoor Residual Spraying (IRS) are the…
(more)
▼ There is a current policy to eliminate malaria in the African continent. Pyrethroid-incorporated Long Lasting Insecticidal Nets (LLINs) and/or Indoor Residual Spraying (IRS) are the chemical weapons being deployed to achieve that goal. Rather worryingly, resistance to pyrethroids is well documented in the major vectors of malaria in Africa, and could decimate the contribution that vector control can make to any successful elimination agenda over the next decade. DDT (Dichlorodiphenyltrichloroethane) for IRS is cost effective but undesirable because of its environmental impact. There is a need to identify pyrethroid resistance mechanisms in the areas being scaled up, evaluate their direct impact on the efficacy of these tools and identify novel tools that might have potential as alternatives to pyrethroids and DDT for net or indoor residual treatments. This thesis reports that pyrethroid, organophosphate (Ops) & carbamate resistance is present in the Mopti (M) and Savanah (S) molecular forms of the major vector of malaria, Anopheles gambiae, in two West African countries, Benin and Ivory Coast where LLINs are currently being deployed,. Mechanisms for pyrethroids include elevated oxidase activities and the knock down resistance (kdr) gene at high frequency (>80%) whereas an insensitive acetylcholinesterase conferred Ops and carbamate resistance. Experimental hut tests in Southern Benin showed that the efficacy of Insecticide Treated Net (ITN) and IRS with the pyrethroid lambdacyalothrin was seriously compromised by pyrethroid resistance in the M form of An. gambiae, as opposed to the North where there is no record of pyrethroid resistance. This type of pyrethroid resistance, now spreading through West African populations of the M molecular form of An. gambiae, appears to have major operational significance in other areas such as Bioko, Niger and Burkina Faso. The alternative candidate insecticides, indoxacarb (an oxadiazine), chlorfenapy (a pyrrole) and chlorpyrifos methyl (an organophosphate) were evaluated, in the laboratory and/or in the field. In the laboratory, indoxacarb and chlorfenapyr on netting were more toxic than permethrin over the same dosage range (100-500mg/m2). Toxic activity was rather slow and bloodfeeding of mosquitoes was uninhibited in the presence of either insecticide. The experimental hut tests conducted in Southern Benin indicated that chlorfenapyr has high potential for IRS, killing 82.9% of pyrethroid resistant An. gambiae and 69% of Culex quinquefasciatus. Likewise, IRS with chlorpyrifos methyl CS (Capsule Suspension) was very efficacious at the same site in Benin. It killed 95.5% of pyrethroid resistant An. gambiae that entered a hut and showed activity on walls that lasted for more than 9 months without significant decay. If applied at high coverage, chlorpyrifos methyl CS should show higher, more-sustained levels of malaria transmission control than that achievable with DDT or pyrethroids. The feasibility of applying synthetic insect repellents on bednets (RTNs) to…
Advisors/Committee Members: Wageningen University, Marcel Dicke, M. Rowland, B.G.J. Knols.
Subjects/Keywords: anopheles gambiae; vectoren, ziekten; malaria; resistentie tegen insecticiden; spreiding; pyrethroïden; carbamaten; organo-fosfaatinsecticiden; diethyltoluamide; vectorbestrijding; bednetten; geïmpregneerde weefsels; Medische entomologie; anopheles gambiae; disease vectors; malaria; insecticide resistance; spread; pyrethroids; carbamates; organophosphate insecticides; diethyltoluamide; vector control; bed nets; impregnated fabrics; Medical Entomology
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
N'Guessan, R. (2009). Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay. (Doctoral Dissertation). NARCIS. Retrieved from http://library.wur.nl/WebQuery/wurpubs/384855 ; urn:nbn:nl:ui:32-384855 ; urn:nbn:nl:ui:32-384855 ; http://library.wur.nl/WebQuery/wurpubs/384855
Chicago Manual of Style (16th Edition):
N'Guessan, R. “Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay.” 2009. Doctoral Dissertation, NARCIS. Accessed March 05, 2021.
http://library.wur.nl/WebQuery/wurpubs/384855 ; urn:nbn:nl:ui:32-384855 ; urn:nbn:nl:ui:32-384855 ; http://library.wur.nl/WebQuery/wurpubs/384855.
MLA Handbook (7th Edition):
N'Guessan, R. “Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay.” 2009. Web. 05 Mar 2021.
Vancouver:
N'Guessan R. Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay. [Internet] [Doctoral dissertation]. NARCIS; 2009. [cited 2021 Mar 05].
Available from: http://library.wur.nl/WebQuery/wurpubs/384855 ; urn:nbn:nl:ui:32-384855 ; urn:nbn:nl:ui:32-384855 ; http://library.wur.nl/WebQuery/wurpubs/384855.
Council of Science Editors:
N'Guessan R. Insecticide resistance in the West African malaria vector Anopheles gambiae and investigation of alternative tools for its delay. [Doctoral Dissertation]. NARCIS; 2009. Available from: http://library.wur.nl/WebQuery/wurpubs/384855 ; urn:nbn:nl:ui:32-384855 ; urn:nbn:nl:ui:32-384855 ; http://library.wur.nl/WebQuery/wurpubs/384855
Tartu University
22.
Balikova, Anna.
Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
.
Degree: 2012, Tartu University
URL: http://hdl.handle.net/10062/25631
► Kasvajates on rakud kaotanud kontrolli jagunemise üle, paljunedes valel ajal ja vales kohas sõltumata välistest signaalidest. Kasvajarakkude piiramatu jagunemine on tingitud kasvu ja ellujäämist soodustavate…
(more)
▼ Kasvajates on rakud kaotanud kontrolli jagunemise üle, paljunedes valel ajal ja vales kohas sõltumata välistest signaalidest. Kasvajarakkude piiramatu jagunemine on tingitud kasvu ja ellujäämist soodustavate valkude ehk onkovalkude aktivatsioonist ning samaaegsest rakusurma reguleerivate valkude ehk tuumorsupressorite inaktivatsioonist. Kasvajaseoseliste valkude hulk kasvab pidevalt, kuid normaalse raku transformeerumine kasvajarakuks toimub tänu muutustele peamistes signaaliülekande radades, mis vastutavad raku surma ja kasvu eest. Seega on kasvajaseoseliste valkude identifitseerimine ja nende funktsioonide uurimine keskse tähtsusega vähivastaste ravistrateegiate väljatöötamisel.
Käesolevas töös uuriti potentsiaalse onkovalgu leukosialiini (CD43) funktsioone inimese kasvajarakkudes. CD43 peeti pikka aega ainult vererakkudele omaseks pinnamolekuliks, kuid järjest enam vihjeid koguneb selle kohta, et CD43 võiks käituda soodustava faktorina mitte-verepäritolu kasvajate tekkes. Mitmed tööd on kirjeldanud kõrget CD43 taset erinevates kasvajarakuliinides ja -kudedes, sealhulgas käärsoolekasvajates. Samas ei ole CD43 leitud normaalsetest soolerakkudest. Samuti on näidatud CD43 seost erinevate signaaliradade komponentidega, mis rakkude elulemust või paljunemist mõjutavad. Antud töö tulemused viitavad, et koostöös tuntud onkovalgu β-kateniiniga soodustab CD43 rakkude ellujäämist ja kasvu. Paljude kasvajate üheks peamiseks tekkepõhjuseks on häired β-kateniini funktsioneerimises, mille tulemusena käivitab β-kateniin rakkude jagunemist stimuleerivate geenide avaldumist. Rakkudes, kus tuumorsupressorite rada on rikutud, võib suurenenud CD43 hulk β-kateniini signaaliraja kaudu viia rakkude kontrollimatu paljunemiseni, mis on aluseks kasvaja moodustumisele. Samas, CD43 ja β-kateniinist lähtuvad liigsed kasvusignaalid kutsuvad rakus esile surmaprotsessi, mis on peamine mehhanism kasvaja tekke takistamisel. Lisaks sellele vähendavad tuumorsupressorid omakorda CD43 hulka rakus. Kokkuvõttes näitavad töö tulemused uusimaid aspekte seoses CD43 võimega rakukasvu soodustada ning seeläbi kasvajat tekitada, ning varem kirjeldamata tagasisidet CD43 ja tuumorsupressorite talitluse vahel, mis võiks olla olulise tähtsusega kasvajate tekke vältimisel.
Subjects/Keywords: Cancer is a complex disease where cells proliferate uncontrollably and spread into different parts of the body. Unlimited division of cancer cells occurs due to activation of proteins that promote cell growth, i.e. oncoproteins, and simultaneous inactivation of proteins that regulate cell death, i.e. tumorsuppressors. Although the number of ascertained cancer-associated proteins continues to grow rapidly, the transformation of a normal cell into a tumor cell depends on changes in several key signaling pathways that regulate cell proliferation and death. Identification of tumor-associated proteins and studying their function might be applied to the elaboration of novel therapeutic strategies.
In this work the functions of a potential oncoprotein leukosialin (CD43) were studied in human cancer cells. CD43 has long been regarded as a molecule present exclusively on the surface of blood cells. However, there is a growing body of evidence suggesting that CD43 might play a role in tumor development. Several studies demonstrate high level of CD43 in human solid tumor cells, including colorectal tumors, but it was not detectable in normal colon cells. Moreover, CD43 has been shown to interact with proteins that influence cell survival or proliferation. The results of the present research imply that CD43 in cooperation with the well known oncoprotein β-catenin facilitates cell growth and survival. It is believed that disorders in the functioning of β-catenin frequently lead to the formation of various types of cancer, especially colorectal cancers, since deregulated β-catenin triggers production of proteins that stimulate cell division. In cells with impaired tumorsuppressors, the increased amount of CD43, via β-catenin signaling, might cause uncontrollable proliferation of cells and initiate a tumor. However, excessive growth signals emanating from CD43 and β-catenin actuate the process of cell death, which is the main protective mechanism against tumors. Furthermore, the tumorsuppressors, in turn, decrease the level of CD43 protein. In summary, this work presents new aspects on the ability of CD43 to enhance cell growth and thereby promote tumor formation. Also, a previously undescribed negative feedback loop is proposed between CD43 and tumorsuppressors that might be important in preventing the disease.;
tumor cells growth;
tumor markers;
molecular aspects;
proteins;
kasvajarakkude kasv;
valgud;
kasvaja markerid;
molekulaaraspektid
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Balikova, A. (2012). Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
. (Thesis). Tartu University. Retrieved from http://hdl.handle.net/10062/25631
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Balikova, Anna. “Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
.” 2012. Thesis, Tartu University. Accessed March 05, 2021.
http://hdl.handle.net/10062/25631.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Balikova, Anna. “Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
.” 2012. Web. 05 Mar 2021.
Vancouver:
Balikova A. Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
. [Internet] [Thesis]. Tartu University; 2012. [cited 2021 Mar 05].
Available from: http://hdl.handle.net/10062/25631.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Balikova A. Studies on the functions of tumor-associated mucin-like leukosialin (CD43) in human cancer cells
. [Thesis]. Tartu University; 2012. Available from: http://hdl.handle.net/10062/25631
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
. 
Open Access Theses and Dissertations
