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Universidade Estadual de Campinas

1. Pereira, Mariane Barroso, 1984-. Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease.

Degree: 2016, Universidade Estadual de Campinas

Abstract: Chagas disease (DC), discovered by Carlos Chagas in 1909, is a disease caused by the protozoan Trypanosoma cruzi. This disease affects millions of people in South and Central America. Nowadays, it is estimated that there are in Brazil between 1.9 million and 4.6 million people infected by this protozoan. In 1991, a campaign was launched to eliminate the vector transmission of the disease in the Southern Cone countries, which resulted in the reduction of acute cases of the disease. The objectives of the study were: to implant genotyping techniques and to classify T. cruzi isolates present in patients with Chagas disease treated by the Chagas Disease Study Group (GEDoCh); correlate with the clinical form and their origin, evaluate the blood culture results and evaluate the efficiency of serological kits. Four tubes were collected with 6mL EDTA for blood culture and a 4 mL dry tube for serum collection. Serological tests and genotyping were performed at the Laboratory of Diagnosis of Infectious Diseases by Techniques of Molecular Biology. Of the 54 samples collected, 26 (48%) were positive in blood culture. Samples of female patients obtained a higher percentage of positive blood culture, as well as in patients with cardiac clinical form and in patients treated with incomplete treatment with benznidazole. After genotyping in DTUs, the TC II was the most prevalent DTU, especially in patients with the cardiac form of CD. In the serological tests, the TESA-cruzi test solved a case of non-reactive serology and it was not possible to correlate the type of DTU found with the serological tests. From this study, it was concluded that: positive blood culture was more prevalent in female patients and cardiac form, the implantation of the genotyping technique was effective and it was possible to genotype the isolates present in the patients collected; two types of DTU were found, with TC III being a rare type in humans Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Costa, Sandra Cecília Botelho, 1951- (advisor), Almeida, Eros Antonio de, 1951- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Clínica Médica (nameofprogram), Gurgel, Cristina Brandt Friedrich Martin (committee member), Fattori, André (committee member), Ferreira, Eduardo de Castro (committee member), Santos, Magnun Nueldo Nunes dos (committee member).

Subjects/Keywords: Polimorfismo de fragmento de restrição; Chagas, Doença de; Técnicas de genotipagem; Unidades discretas de tipagem; Polymorphism, Restriction fragment length; Chagas disease; Genotyping techniques; Discrete type unit

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APA (6th Edition):

Pereira, Mariane Barroso, 1. (2016). Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/321970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pereira, Mariane Barroso, 1984-. “Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease.” 2016. Thesis, Universidade Estadual de Campinas. Accessed November 30, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/321970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pereira, Mariane Barroso, 1984-. “Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease.” 2016. Web. 30 Nov 2020.

Vancouver:

Pereira, Mariane Barroso 1. Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2020 Nov 30]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira, Mariane Barroso 1. Genotipagem de "Trypanosoma cruzi" isolados de pacientes portadores da doença de Chagas: Genotyping of Trypanosoma cruzi isolated from patients with Chagas disease. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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