subject:(Direct arylation)

University of Ottawa

1. Petrov, Ivan. The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics .

Degree: 2011, University of Ottawa

URL: http://hdl.handle.net/10393/19788

► The regioselectivity in Pd(0)-catalyzed direct arylation of pyrrole, thiophene, and indole can be improved by blocking some of the reactive sites with a chloride group,… (more)

Subjects/Keywords: direct arylation; chlorination; heteroaromatics; palladium catalysis

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APA (6^th Edition):

Petrov, I. (2011). The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/19788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrov, Ivan. “The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics .” 2011. Thesis, University of Ottawa. Accessed January 27, 2021. http://hdl.handle.net/10393/19788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrov, Ivan. “The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics .” 2011. Web. 27 Jan 2021.

Vancouver:

Petrov I. The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics . [Internet] [Thesis]. University of Ottawa; 2011. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10393/19788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrov I. The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics . [Thesis]. University of Ottawa; 2011. Available from: http://hdl.handle.net/10393/19788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Rovira i Virgili

2. de Mendoza Bonmatí, Paula. Design and synthesis of new polyaromatic scaffolds for nano-scale applications.

Degree: Departament de Química Analítica i Química Orgànica, 2010, Universitat Rovira i Virgili

URL: http://hdl.handle.net/10803/9045

► Design and Synthesis of New Polyaromatic Scaffolds for Nano-Scale Applications Resumen: En la última década, el diseño y la síntesis de nuevos sistemas poliaromáticos han… (more)

▼ Design and Synthesis of New Polyaromatic Scaffolds for Nano-Scale Applications Resumen: En la última década, el diseño y la síntesis de nuevos sistemas poliaromáticos han resultado de gran interés gracias a sus propiedades únicas y sus aplicaciones potenciales para la obtención de dispositivos electrónicos, y como precursores de fullerenos. Hemos estudiado el mecanismo que procede a través de la activación del enlace C-H en la reacción intramolecular de arilación directa catalizada por paladio, para la formación de sistemas biarílicos, demostrando que la reacción procede a través de la abstracción del protón asistido por la base. Aplicando condiciones optimizadas hemos preparado la molécula C60H24 que al ser irradiada da lugar a la formación del fullereno C60, mediante la reacción de arilación directa formando seis nuevos enlaces C-C en una única etapa. Además, en una colaboración interdisciplinar con físicos teóricos y experimentales, en el proyecto PicoInside, hemos participado en el diseño y la síntesis de moléculas poliaromáticas para su posterior aplicación como dispositivos electrónicos moleculares. Abstract: In the last decade, the design and synthesis of new polyaromatic scaffolds have attracted a broad interest due to their exceptional properties and their potential applications in material science like molecular electronic devices and as precursors of fullerene. Based in the intramolecular palladium-catalyzed direct arylation reaction we developed new procedures as reliable tools for the biaryl coupling through C-H activation. Insight mechanistic studies showed a proton abstraction mechanism assisted by the base rather than activation of aromatic systems towards electrophilic attack. Applying optimized reaction conditions, formation up to six C-C bonds, and in situ dehydrogenation, allows for the synthesis of C60H24, crushed fullerene in one single step that upon laser irradiation leads to C60 fullerene. Moreover, in an interdisciplinary collaboration with theoretical and experimental physicist, PicoInside project, we have participated in the design and synthesis of Y-shaped polyaromatic molecules required for single molecule electronic devices. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Echavarren, Antonio M. (director).

Subjects/Keywords: Molecular Electronics; Direct Arylation; PAHs; 542; 547

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APA (6^th Edition):

de Mendoza Bonmatí, P. (2010). Design and synthesis of new polyaromatic scaffolds for nano-scale applications. (Thesis). Universitat Rovira i Virgili. Retrieved from http://hdl.handle.net/10803/9045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

de Mendoza Bonmatí, Paula. “Design and synthesis of new polyaromatic scaffolds for nano-scale applications.” 2010. Thesis, Universitat Rovira i Virgili. Accessed January 27, 2021. http://hdl.handle.net/10803/9045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

de Mendoza Bonmatí, Paula. “Design and synthesis of new polyaromatic scaffolds for nano-scale applications.” 2010. Web. 27 Jan 2021.

Vancouver:

de Mendoza Bonmatí P. Design and synthesis of new polyaromatic scaffolds for nano-scale applications. [Internet] [Thesis]. Universitat Rovira i Virgili; 2010. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10803/9045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

de Mendoza Bonmatí P. Design and synthesis of new polyaromatic scaffolds for nano-scale applications. [Thesis]. Universitat Rovira i Virgili; 2010. Available from: http://hdl.handle.net/10803/9045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

3. Shanahan, Rachel. Synthesis of nitrogen-containing heterocycles.

Degree: 2019, University College Cork

URL: http://hdl.handle.net/10468/10087

► The sharp rise in antimicrobial resistance has been matched by a decline in the identiﬁcation and clinical introduction of new classes of drugs to treat… (more)

▼ The sharp rise in antimicrobial resistance has been matched by a decline in the identiﬁcation and clinical introduction of new classes of drugs to treat microbial infections. Thus new approaches are being sought to target pathogenic microorganisms. In that context, the use of non-biocidal small molecules, that target quorum sensing signalling networks in pathogens, has emerged as a solution with real clinical potential. Previous work has shown that two alkyl quinolone signal molecules (HHQ and PQS) from the nosocomial pathogen Pseudomonas aeruginosa have modulatory activity towards other microorganisms. Chapter 1 of this thesis outlines the synthesis of analogues of HHQ with the aim of learning more about the structure activity relationship of alkyl quinolone quorum sensing molecules. Chapter 2 of this thesis describes work carried out during a six month work placement at Syngenta Crop Protection in Stein, Switzerland. The project involved efforts towards a new total synthesis of pyridohomotropane (PHT), a synthetic alkaloid which has shown agonistic activity towards nicotinic acetylcholine receptors (nAChRs). Since they are found in the central nervous system of insects, nAChRs are a key target of insecticidal crop protection products. This chapter outlines the retrosynthetic analysis and synthesis of key intermediates towards the total synthesis of PHT. The formation of aryl aryl bonds is an important transformation in organic synthesis due to the abundance of aryl aryl moieties in natural products and pharmaceuticals. Direct arylation strategies aim to avoid the installation of one or both of the activating groups typically required for traditional cross coupling methods. The application of direct arylation protocols towards the synthesis of polycyclic benzofuroquinoline compounds is described in Chapter 3. Expansion of the methodology to facilitate a one pot tandem reaction combining Suzuki Miyaura and direct arylation transformations is also discussed. Finally, the retention of specific carbon bromide bonds of the quinoline substrates is achieved via a reversible oxidative addition protocol. Advisors/Committee Members: Mcglacken, Gerard P..

Subjects/Keywords: Synthesis; Direct arylation; Total synthesis; Quinolone; Quinoline

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APA (6^th Edition):

Shanahan, R. (2019). Synthesis of nitrogen-containing heterocycles. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/10087

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shanahan, Rachel. “Synthesis of nitrogen-containing heterocycles.” 2019. Thesis, University College Cork. Accessed January 27, 2021. http://hdl.handle.net/10468/10087.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shanahan, Rachel. “Synthesis of nitrogen-containing heterocycles.” 2019. Web. 27 Jan 2021.

Vancouver:

Shanahan R. Synthesis of nitrogen-containing heterocycles. [Internet] [Thesis]. University College Cork; 2019. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10468/10087.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shanahan R. Synthesis of nitrogen-containing heterocycles. [Thesis]. University College Cork; 2019. Available from: http://hdl.handle.net/10468/10087

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

4. Rudenko, Andrey E. Direct arylation polymerization (DARP) for the synthesis of conjugated polymers.

Degree: PhD, Chemistry, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/419336/rec/2011

► Direct Arylation Polymerization (DArP) has emerged recently as a C-H activation method of synthesis for conjugated polymers. It represents an attractive alternative to traditional methods… (more)

▼ Direct Arylation Polymerization (DArP) has emerged recently as a C-H activation method of synthesis for conjugated polymers. It represents an attractive alternative to traditional methods of transition metal catalyzed cross-coupling polymerization methods, such as Stille, Suzuki, Negishi and Kumada polymerization, due to elimination of the metalation step, elimination of the need to purify the metalated monomers, which often is very challenging, and in case of popular Stille polymerization, elimination of toxic organotin byproducts. DArP has emerged only recently through application of known procedures for small molecule synthesis to polymerizations. The focus of this work is development of DArP conditions to produce conjugated polymers with desired structure and target properties. This work brings new understanding of several aspects of aromatic C-H activation chemistry on polymers chains and opens a new frontier of precise control of polymer structure via modification of reaction parameters. ❧ The application of small molecule direct arylation reaction condition for specific polymer synthesis is not straightforward and as it is definitively shown in this work, a simple translation is not sufficient for the synthesis of high quality conjugated polymers of optoelectronic grade since unacceptably high amount of various defects is produced in the resulting polymers. To systematize the existing knowledge of conjugated polymer defects, Chapter 1 focuses on comprehensive treatment of polymer structural defects that are inherent to conjugated polymers synthesized via DArP in terms of definition and origin of defects, their influence on polymer properties and, finally, the available techniques to control their quantity. ❧ Chapter 2 describes direct application of the small molecule direct arylation cross-coupling conditions for the synthesis of poly(3-hexylthiophene) (P3HT) and P3HT-based semi-random analogs. The resulting polymers are thoroughly characterized in terms of their chemical structure, the optical, electronic and thermal properties and it is found that all polymer properties are significantly different from same polymers prepared via the established Stille polymerization. These differences are attributed to the presence of beta-defects, or branching, that are thought to originate from lack of selectivity of the catalytic system. It is postulated that these defects can be eliminated if the catalytic system activity is appropriately tuned. ❧ Chapter 3 describes tuning of the catalytic system to eliminate beta-defects. It was found that such tuning is possible without complication of the reaction with expensive and unstable reaction components. Instead, the desired polymer properties were obtained simply by tuning reaction temperature, catalyst loading, reaction time and utilization of a bulkier carboxylate ligand. Such tuning allowed the complete convergence of all the properties of DArP P3HT with those of previously reported Stille P3HT. In Chapter 4 several samples were selected from the previous study to… Advisors/Committee Members: Thompson, Barry C. (Committee Chair), Prakash, G. K. Surya (Committee Member), Nakano, Aiichiro (Committee Member).

Subjects/Keywords: conjugated polymer; structure; defects; direct arylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rudenko, A. E. (2014). Direct arylation polymerization (DARP) for the synthesis of conjugated polymers. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/419336/rec/2011

Chicago Manual of Style (16^th Edition):

Rudenko, Andrey E. “Direct arylation polymerization (DARP) for the synthesis of conjugated polymers.” 2014. Doctoral Dissertation, University of Southern California. Accessed January 27, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/419336/rec/2011.

MLA Handbook (7^th Edition):

Rudenko, Andrey E. “Direct arylation polymerization (DARP) for the synthesis of conjugated polymers.” 2014. Web. 27 Jan 2021.

Vancouver:

Rudenko AE. Direct arylation polymerization (DARP) for the synthesis of conjugated polymers. [Internet] [Doctoral dissertation]. University of Southern California; 2014. [cited 2021 Jan 27]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/419336/rec/2011.

Council of Science Editors:

Rudenko AE. Direct arylation polymerization (DARP) for the synthesis of conjugated polymers. [Doctoral Dissertation]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/419336/rec/2011

Georgia Tech

5. Ponder, James. A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications.

Degree: PhD, Chemistry and Biochemistry, 2017, Georgia Tech

URL: http://hdl.handle.net/1853/60158

► Redox active conjugated polymers are used in a variety of applications including electrochromism, charge storage, plasmonic resonance tuning, and electrochemical transistors. This thesis describes the… (more)

▼ Redox active conjugated polymers are used in a variety of applications including electrochromism, charge storage, plasmonic resonance tuning, and electrochemical transistors. This thesis describes the development of processable, electron-rich dioxyheterocycle-based polymers for use in electrochromic and charge-storage applications. This thesis reports the development of soluble polymers that can be solution processed from organic or aqueous solutions (inks) and are redox active in organic or aqueous electrolytes with variable optical and redox properties through subtle differences in the repeat units and heteroatoms used. This thesis describes the development of processable, electron-rich dioxyheterocycle-based polymers for use in electrochromic and charge-storage applications. Materials with low onsets of oxidation and broad electroactivity over a large voltage window, as seen with electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT), are of interest for charge storage applications. Chapter 3 reports and discusses the copolymerization of alkoxy-functionalized 3,4-propylenedioxythiophenes (ProDOTs) with unfunctionalized 3,4-ethylenedioxythiophene (EDOT) in varying ratios using direct arylation to produce a series of solution processable polymers with highly tunable optical and electronic properties. Within this series, we have identified poly(ProDOT-alt-biEDOT) (PE2), a copolymer containing 67% EDOT compositionally, which combines the low oxidation potential, the redox behavior, and the deep-blue neutral color that are characteristic of PEDOT with the high solubility, exceptional electrochromic contrast, and color neutrality in the oxidized state characteristic of alkoxy-functionalized polyProDOTs. 3,4-Phenylenedioxythiophene (PheDOT) is a unit that is similar to EDOT in terms of planarity and steric interactions but has different electronic properties due to an attached phenyl ring that allows for electron delocalization away from the thiophene ring. This unit, and its use in soluble copolymers prepared via direct (hetero) arylation polymerization (DHAP), is discussed in Chapter 4. The notable C-H inactivity of the attached phenylene unit is compared to aromatic solvents used for DHAP and the redox stability of these copolymers are demonstrated. The first example of a solution processable dioxythiophene-alt-dioxyselenophene polymer, poly(ProDOT-alt-EDOS), prepared via DHAP is reported and its optical and electrochemical properties are compared to the all thiophene analog and other relevant dioxythiophene polymers. By substituting the sulfur atom for a selenium atom on one of the monomers in the repeat unit, a significant red-shift of both the neutral and polaronic absorbances results, as well as a reduction in the onset of oxidation compared to the all thiophene analog.Due to the redox and optical similarities of PE2 and PEDOT, the solid-state electrical conductivity of the chemically doped ProDOTxEDOTy series (discussed in Chapter 3) is studied in Chapter 6. Additional polymer structures are introduced to… Advisors/Committee Members: Reynolds, John R. (advisor), Marder, Seth R. (committee member), France, Stefan (committee member), Reichmanis, Elsa (committee member), Bottomley, Lawrence A. (committee member).

Subjects/Keywords: Conjugated polymers; Dioxythiophene; Supercapacitor; Electrochromism; Direct arylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ponder, J. (2017). A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/60158

Chicago Manual of Style (16^th Edition):

Ponder, James. “A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications.” 2017. Doctoral Dissertation, Georgia Tech. Accessed January 27, 2021. http://hdl.handle.net/1853/60158.

MLA Handbook (7^th Edition):

Ponder, James. “A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications.” 2017. Web. 27 Jan 2021.

Vancouver:

Ponder J. A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications. [Internet] [Doctoral dissertation]. Georgia Tech; 2017. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1853/60158.

Council of Science Editors:

Ponder J. A Pedot by any other name: Tuning the electroactivity of dioxy-heterocycles for redox and solid state applications. [Doctoral Dissertation]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/60158

Georgia Tech

6. Deininger, James J. Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications.

Degree: MS, Chemistry and Biochemistry, 2015, Georgia Tech

URL: http://hdl.handle.net/1853/53873

► Conjugated polymers are currently being used for a wide range of electronic applications. In this thesis, we studied two different synthetic approaches that lead to… (more)

Subjects/Keywords: Polymer; Elctrochromic; Conjugated polymer; Dithienogermole; Photovoltaic; Direct (hetero)arylation; Direct arylation; Polymerizations; 3,4-propylenedioxythiophene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deininger, J. J. (2015). Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/53873

Chicago Manual of Style (16^th Edition):

Deininger, James J. “Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications.” 2015. Masters Thesis, Georgia Tech. Accessed January 27, 2021. http://hdl.handle.net/1853/53873.

MLA Handbook (7^th Edition):

Deininger, James J. “Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications.” 2015. Web. 27 Jan 2021.

Vancouver:

Deininger JJ. Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications. [Internet] [Masters thesis]. Georgia Tech; 2015. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1853/53873.

Council of Science Editors:

Deininger JJ. Synthesis of pi conjugated polymers for use in photovoltaic and electrochromic applications. [Masters Thesis]. Georgia Tech; 2015. Available from: http://hdl.handle.net/1853/53873

Universiteit Utrecht

7. Huang, Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/324941

► In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations… (more)

▼ In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations catalyzed by Fe, Co, Ni and Cu are mainly demonstrated and discussed. Chapter 2 described a pre-made iron-based catalytic system that is able to catalyze the direct arylation reaction between aryl halides and unactivated arenes under aerobic conditions and using non-distilled benzene as solvent and reagent. Chapter 3 focuses on unraveling structural information of the FPsystem and acquiring an understanding of the evolution of iron species during the direct arylation reactions. By employing a combination of IR, UV-Vis and XAS (XANES and EXAFS) techniques, together with the information from elemental analysis and ICP-OES, a conclusion can be draw that the main component in different FPE systems is almost the same, while in FPM systems (generated in methanol) these are quite different. The constitution of the main component in FP2Eand FP1M was proposed to be [Fe(phen)Cl3(CH3CH2OH)]∙0.5CH3CH2OH ∙0.5phen and [Fe(phen)2Cl2][FeCl4], respectively. Further investigation of FP2Esystems was performed in Chapter 4. First, a kinetic study of the FP2Ecatalyzed direct aryaltion of 4-iodoanisole and benzene in air under reflux was carried out. The comparison of catalytic reactivity of FPE and FPM systems were carried out in this chapter, too. In Chapter 5 the application of FP2E in the Heck-type reaction between 4-iodoanisole and styrene in air was investigated. However, initial results showed that the combination of the applied base and alcohol additive is able to catalyze such transformations in air albeit with moderate yield (58%). Following the observation, the effects of base, alcohol additive, and solvent on the air tolerance of this kind of reaction were investigated in this chapter. The employment of KOtBu and DMF proved to be crucial to the success of the Heck-type reaction in air with non-distilled solvent. A possible mechanism was proposed, which involves radical intermediates formed from the reaction between KOtBu and DMF. Advisors/Committee Members: Klein Gebbink, Bert, Moret, Marc-Etienne.

Subjects/Keywords: iron; direct arylation; air tolerant; kinetic study; Heck reaction; radical

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APA (6^th Edition):

Huang, Y. (2015). Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/324941

Chicago Manual of Style (16^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed January 27, 2021. http://dspace.library.uu.nl:8080/handle/1874/324941.

MLA Handbook (7^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Web. 27 Jan 2021.

Vancouver:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Jan 27]. Available from: http://dspace.library.uu.nl:8080/handle/1874/324941.

Council of Science Editors:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/324941

University of Ottawa

8. Sun, Ho-Yan. Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step .

Degree: 2011, University of Ottawa

URL: http://hdl.handle.net/10393/19760

► Detailed mechanistic studies on the palladium-catalyzed direct arylation of pyridine N-oxides are presented. The order of each reaction component is determined to provide a general… (more)

Subjects/Keywords: N-Oxide; Palladium; Catalytic Direct Arylation; Mechanism; Concerted Metallation-Deprotonation

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APA (6^th Edition):

Sun, H. (2011). Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/19760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sun, Ho-Yan. “Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step .” 2011. Thesis, University of Ottawa. Accessed January 27, 2021. http://hdl.handle.net/10393/19760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sun, Ho-Yan. “Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step .” 2011. Web. 27 Jan 2021.

Vancouver:

Sun H. Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step . [Internet] [Thesis]. University of Ottawa; 2011. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10393/19760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sun H. Studies on the Mechanism of Direct Arylation of Pyridine N oxides: Evidence for the Essential Involvement of Acetate from the Pd(OAc)2 Pre-Catalyst at the C-H Bond Cleaving Step . [Thesis]. University of Ottawa; 2011. Available from: http://hdl.handle.net/10393/19760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

9. Geary, Laina Michelle. A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene.

Degree: Chemistry, 2011, University of Manitoba

URL: http://hdl.handle.net/1993/4381

► Trichloroethylene, a simple and very inexpensive material, has been identified as a tri- and tetrafunctionalizable building block. A combination of selective palladium-catalyzed cross-coupling reactions with… (more)

▼ Trichloroethylene, a simple and very inexpensive material, has been identified as a tri- and tetrafunctionalizable building block. A combination of selective palladium-catalyzed cross-coupling reactions with standard lithiation and electrophilic quenching yields a wide variety of unsaturated linear or cyclic compounds in excellent yields in few synthetic steps. Dichlorovinyl ethers, obtained from a nucleophilic displacement reaction with trichloroethylene, are the basic starting materials. Two sets of conditions have been developed to achieve the reaction of either electron-rich or –deficient phenols with trichloroethylene to give the resultant dichlorovinyl ethers in high yields. Site selective palladium-catalyzed cross-coupling for the specific functionalization of a single C-Cl bond was developed, and could install alkyl, alkenyl, alkynyl and (hetero)aryl moieties. The resulting electrophiles could be reacted with a second organometallic nucleophile forming trisubstituted, electron-rich alkenes, dienes, trienes or enynes in only two or three steps. Alternatively, the product from the first cross-coupling reaction could be isolated, deprotonated and quenched with an electrophile, then cross-coupled with a second organometallic nucleophile to give tetrasubstituted, electron-rich alkenes and dienes. In the course of studying the site selective cross-coupling, it was found that prolonged exposure of the C1-functionalized materials to palladium promoted an intramolecular C-H activation, forming 2-substituted benzofurans. This reaction proved to be very general, and a wide variety of benzofurans were synthesized, containing both electron-withdrawing and electron-donating group groups in the donor arenes, as well as alkyl, alkenyl, alkynyl and aryl functionalities at the 2-position. This method was also extended to the synthesis of 2-substituted indoles from anilines, trichloroethylene and boronic acids. Advisors/Committee Members: Hultin, Philip G. (Chemistry) (supervisor), Budzelaar, Peter H. M. (Chemistry).

Subjects/Keywords: palladium; heterocycles; direct arylation; cross-coupling; boronic acids; trichloroethylene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Geary, L. M. (2011). A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/4381

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Geary, Laina Michelle. “A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene.” 2011. Thesis, University of Manitoba. Accessed January 27, 2021. http://hdl.handle.net/1993/4381.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Geary, Laina Michelle. “A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene.” 2011. Web. 27 Jan 2021.

Vancouver:

Geary LM. A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene. [Internet] [Thesis]. University of Manitoba; 2011. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1993/4381.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Geary LM. A diversity-oriented approach to the palladium-catalyzed modular assembly of conjugated compounds and heterocycles: high-value compounds from trichloroethylene. [Thesis]. University of Manitoba; 2011. Available from: http://hdl.handle.net/1993/4381

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

INP Toulouse

10. Oukhrib, Abdelouahd. Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions.

Degree: Docteur es, Chimie Organométallique et de Coordination, 2015, INP Toulouse

URL: http://www.theses.fr/2015INPT0029

►

Transformer des produits naturels, les fonctionnaliser par hémi-synthèse ou par voie catalytique est un outil intéressant pour élargir le spectre des structures accessibles et de… (more)

▼

Transformer des produits naturels, les fonctionnaliser par hémi-synthèse ou par voie catalytique est un outil intéressant pour élargir le spectre des structures accessibles et de développer ainsi de nouvelles molécules à potentialité biologique. Nous nous sommes intéressés à la valorisation de sesquiterpènes isolés de l’huile essentielle du Cédres de l’Atlas qui représentent une famille de molécules naturelles abondantes et de faible coût. La première partie de ce travail porte sur des réactions d’hémisynthèse des himachalènes et des α-atlantones par des voies classiques d’époxydation, de dihalogéno cyclopropanation, de Grignard et de Wittig,dans le but d’accroître l’activité biologique reconnue de la molécule naturelle ou de découvrir de nouvelles activités. Les dérivés oléfiniques synthétisés ont été ensuite impliqués dans la réaction d’hydroformylation catalysée par des complexes au rhodium. Cette seconde partie décrit dans un premier temps la synthèse des ligands phospholes et biphospholes chiraux impliqués dans cette réaction. La performance des ligands a été évaluée dans la réaction d’hydroformylation de substrats modèles tels que le styrène, l’octène et l’α-méthylstyrèneet celle des ligands biphosphosles chiraux dans la version asymétrique de la réaction avecle styrène. Ensuite,la réaction a été étudiée sur les composés oléfiniques dérivés des α-atlantones. Les systèmes catalytiques [Rh(acac)(CO)2]/phospholes se montrent actifs e donnent de bonnes chimio- et régiosélectivité en faveur de l’aldéhyde linéaire. Nous avons également réalisé des réactions tandem d’hydroformylation/Wittig/hydroformylation pour obtenir des aldéhydes à long chaines aliphatiques ainsi que les réactions hydroformylation/acétalisation des alcools homo- et allyliques dérivé des α- atlantones afin d’accéder aux motifs lactones après oxydation des hemiacétals correspondants. La dernière partie est consacrée à la synthèse des nouveaux ligands pyrrol-phosphine (phosphole) (P-N) et leur évaluation dans la réaction d’arylation directe intramoléculaire catalysée des complexes du palladium sous micro-ondes. Cette réaction permet d’accéder à des lactones présentant un motif «dibenzo-pyranone».Les complexes associés avec les ligands pyrrol-phosphine montrent de bons résultats en termes de conversion et sélectivité. Un effet électronique remarquable des substituants des esters biaryles sur la chimiosélectivité de la réaction a été observé.

The functionnalisation of natural products by hemisynthesis or catalytic reactions is a useful tool to accessand develop newinteresting molecules with biological properties.We have been interested in chemical transformation of the sesquiterpenes isolated from the essential oil of Atlas Cedar, which represent a family of abundant and inexpensive natural molecules The first part of this work concerns the hemisynthesis reactions on the himachalènes and α-atlantones by classical epoxidation, dihalogénocyclopropanation, Grignard and Wittig reactions with the aim to increase the known biological activity or to…

Advisors/Committee Members: Urrutigoïty, Martine (thesis director), Benharref, Ahmed (thesis director).

Subjects/Keywords: Terpènes; Hydroformylation; Ligands phosphorés; Rhodium; Palladium; Arylation directe intramoléculaire; Terpene; Hydroformylation; Phosphorus ligand; Rhodium; Palladium; Intramolecular arylation direct

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oukhrib, A. (2015). Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions. (Doctoral Dissertation). INP Toulouse. Retrieved from http://www.theses.fr/2015INPT0029

Chicago Manual of Style (16^th Edition):

Oukhrib, Abdelouahd. “Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions.” 2015. Doctoral Dissertation, INP Toulouse. Accessed January 27, 2021. http://www.theses.fr/2015INPT0029.

MLA Handbook (7^th Edition):

Oukhrib, Abdelouahd. “Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions.” 2015. Web. 27 Jan 2021.

Vancouver:

Oukhrib A. Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions. [Internet] [Doctoral dissertation]. INP Toulouse; 2015. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2015INPT0029.

Council of Science Editors:

Oukhrib A. Valorisation des terpènes par formation des nouvelles liaisons C-C et C-X par voie catalytique et hémisynthèse : Terpenes valuation by forming new bonds C-C and C-X by catalytically and hemisynthesis reactions. [Doctoral Dissertation]. INP Toulouse; 2015. Available from: http://www.theses.fr/2015INPT0029

11. Naas, Mohammed. Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential.

Degree: Docteur es, Chimie organique. Pharmacochimie, 2016, Orléans; Université Mohamed V

URL: http://www.theses.fr/2016ORLE2009

►

L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte,… (more)

▼

L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles. Dans la première partie, nous avons étudié la sélectivité des couplages de type Suzuki, pour fonctionnaliser la position 3 d’indazoles possédant la fonction NH libre. Par la suite, un nouveau procédé d’(hétéro)arylation direct pallado-catalysé régiosélectif a été mis à profit pour synthétiser des indazoles fonctionnalisés tant sur la position 3 que sur le sommet 7. Nous avons ensuite montré la possibilité d’accéder à des entités disubstituées indazoliques en une seule étape, via une procédure "one-pot". Afin d’accroître la diversité autour du noyau indazole, nous avons mis au point une réaction d’alcénylation oxydative pallado-catalysée, des (2H)- et (1H)-indazoles sur les sommets C-3 et C-7. Pour exemplifier cette méthodologie, nous avons développé une synthèse en trois étapes du Gamendazole, composé actuellement en phase clinique pour la contraception masculine et ce, en utilisant l’alcénylation directe en C3 d’(1H)-indazoles convenablement fonctionnalisés. Le dernier volet de ce mémoire a été consacré à la préparation de composés à structure indazolique contenant une fonction sulfonamide afin de générer des librairies de dérivés substitués par un tel motif, dans le but de les tester biologiquement dans le domaine des anticancéreux.

Access to new biologically active compounds requires the development of new rapid and efficient methods for the synthesis of original heterocyclic scaffolds. In this context, we decided to focus particularly on the reactivity of indazoles. First, we studied the selectivity of Suzuki cross-coupling reaction to functionalize position 3 of the indazole with the free NH function. Indeed, we have described the first example of the direct and regioselective palladium-catalyzed (hetero)arylation of indazoles, the reaction may be induced to occur at either in position 3 and 7. We then showed the possibility of "one-pot" synthesis of disubstituted indazolic entities. Moreover, in order to increase diversity around the indazole scaffold, we developed a direct and regioselective alkenylation of (2H)- and (1H)-indazoles by oxidative palladium catalyzed at the C-3 and C-7, then we envisaged a three staps synthesis of Gamendazole, molecule currently in clinical phase for male contraception, by using the direct alkenylation at C3 of the suitably functionalized (1H)-indazoles. The last part of this report was dedicated to the preparation of indazoles containing a sulphonamide function, with the aim of biological testing them as potentially anti-cancer candidates.

Advisors/Committee Members: Guillaumet, Gérald (thesis director), Essassi, Mokhtar El (thesis director), El Kazzouli, Saïd (thesis director).

Subjects/Keywords: Indazoles; Suzuki-Miyaura; (hétéro)arylation directe; Alcénylation directe; One-pot; Réactions pallado-catallysées; Indazoles; Suzuki-Miyaura cross-coupling; Direct (hetero)arylation; Direct alkenylation; One-pot; Palladium-catalyzed reactions; 547.59

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Naas, M. (2016). Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential. (Doctoral Dissertation). Orléans; Université Mohamed V. Retrieved from http://www.theses.fr/2016ORLE2009

Chicago Manual of Style (16^th Edition):

Naas, Mohammed. “Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential.” 2016. Doctoral Dissertation, Orléans; Université Mohamed V. Accessed January 27, 2021. http://www.theses.fr/2016ORLE2009.

MLA Handbook (7^th Edition):

Naas, Mohammed. “Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential.” 2016. Web. 27 Jan 2021.

Vancouver:

Naas M. Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential. [Internet] [Doctoral dissertation]. Orléans; Université Mohamed V; 2016. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2016ORLE2009.

Council of Science Editors:

Naas M. Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique : Synthesis of new indazoles derivatives with therapeutic potential. [Doctoral Dissertation]. Orléans; Université Mohamed V; 2016. Available from: http://www.theses.fr/2016ORLE2009

Universidade Estadual de Campinas

12. Biajoli, Andre Francisco Pivato, 1978-. Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils.

Degree: 2013, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249872

► Abstract: Aryldiazonium tetrafluoroborates are stable, easy-to-prepare compounds that have been largely employed in Heck-Matsuda reactions, allowing the development of fast, mild and phosphine-free methods. Regarding… (more)

Subjects/Keywords: Arilação direta; Sais de arenodiazônio; Paládio; Heteroaromáticos; Direct arylation; Diazonium salts; Palladium; Heteroaromatics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Biajoli, Andre Francisco Pivato, 1. (2013). Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/249872

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Biajoli, Andre Francisco Pivato, 1978-. “Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils.” 2013. Thesis, Universidade Estadual de Campinas. Accessed January 27, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249872.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Biajoli, Andre Francisco Pivato, 1978-. “Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils.” 2013. Web. 27 Jan 2021.

Vancouver:

Biajoli, Andre Francisco Pivato 1. Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Jan 27]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249872.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Biajoli, Andre Francisco Pivato 1. Arilação direta de compostos heteroaromáticos com sais de arenodiazônio: SPME (Solid Phase Microextraction) fibers coated with new sol-gel ormosils. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249872

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ottawa

13. Schipper, Derek. Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis .

Degree: 2011, University of Ottawa

URL: http://hdl.handle.net/10393/20121

► Part 1: Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis. These reactions are attractive because of they allow… (more)

▼ Part 1: Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis. These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates. Of these processes, direct arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry. Also, alkyne hydroarylation has garnered interest because it allows for the atom-economical synthesis of functionalized alkenes directly from simple arenes and alkynes. Described in this thesis are number of advancements in these areas. First, palladium catalyzed direct arylation of azine N-oxides using synthetically important aryl triflates is described. Interesting reactivity of aryl triflates compared to aryl bromides was uncovered and exploited in the synthesis of a compound that exhibits antimalarial and antimicrobial activity. Also reported is the efficient, direct arylation enabled (formal) synthesis of six thiophene based organic electronic materials in high yields using simple starting materials. Additionally, the site-selective direct arylation of both sp2 and sp3 sites on azine N-oxide substrates is described. The arylation reactions are carried out in either a divergent manner or a sequential manner and is applied to the synthesis of the natural products, Papaverine and Crykonisine. Mechanistic investigations point towards the intimate involvement of the base in the mechanism of these reactions. Next, the rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes and arenes with excellent regioselectivity for unsymmetrically substituted alkynes. Mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity. Part 2: Access to single enantiomer compounds is a fundamental goal in organic chemistry and despite remarkable advances in enantioselective synthesis, their preparation remains a challenge. Kinetic resolution of racemic products is an important method to access enantioenriched compounds, especially when alternative methods are scarce. Described in this thesis is the resolution of tertiary and secondary alcohols, which arise from ketone and aldehyde aldol additions. The method is technically simple, easily scalable, and provides tertiary and secondary alcohols in high enantiomeric ratios. A rationale for the unique reactivity/selectivity associated with (1S,2R)-N-methylephedrine in the resolution is proposed. Organocatalysis is a rapidly developing, powerful field for the construction of enantioenriched organic molecules. Described here is a complimentary class of organocatalysis using simple aldehydes as temporary tethers to perform challenging formally intermolecular reactions at room temperature. This strategy allows for the enantioselective, intermolecular…

Subjects/Keywords: direct arylation; enantioselective; hydroarylation; kinetic resolution; C-H functionalization; organocatalysis; palladium; rhodium

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schipper, D. (2011). Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/20121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schipper, Derek. “Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis .” 2011. Thesis, University of Ottawa. Accessed January 27, 2021. http://hdl.handle.net/10393/20121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schipper, Derek. “Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis .” 2011. Web. 27 Jan 2021.

Vancouver:

Schipper D. Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis . [Internet] [Thesis]. University of Ottawa; 2011. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10393/20121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schipper D. Part 1: Transition Metal Catalyzed Functionalization of Aromatic C-H Bonds / Part 2: New Methods in Enantioselective Synthesis . [Thesis]. University of Ottawa; 2011. Available from: http://hdl.handle.net/10393/20121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Bassoude, Ibtissam. Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity.

Degree: Docteur es, Chimie, 2012, Orléans; Université Mohammed V-Agdal (Rabat, Maroc)

URL: http://www.theses.fr/2012ORLE2025

►

Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l’accès de façon rapide et efficace à différents dérivés… (more)

▼

Nos travaux de thèse portent sur la mise au point de nouvelles méthodes de synthèse permettant l’accès de façon rapide et efficace à différents dérivés pyrazolo[1,5-a]pyrimidiniques diversement fonctionnalisés.La première partie de ce travail concerne l’étude et l’application de la condensation de la pyran-2-one avec les 5(3)-amino-3(5)-arylpyrazoles que ce soit par chauffage classique ou sous irradiation micro-onde. Par la suite, un nouveau procédé d’(hétéro)arylation pallado-catalysé direct régiosélectif a été mis à profit pour élaborer des pyrazolo[1,5-a]pyrimidines fonctionnalisées tant en position 3 que sur le méthyle situé sur le sommet 7 de la 5,7-diméthylpyrazolo[1,5-a]pyrimidine.Le dernier volet de ce mémoire a été consacré à la préparation des entités pyrazolo[1,5-a]pyrimidiniques substituées en position 7 par des motifs benzyliques et ce, via une procédure « one-pot », sous irradiation micro-onde, constituée d’une réaction d’arylation directe pallado-catalysée suivie d’une saponification-décarboxylation.

Our thesis works concern the development of new methods of synthesis allowing a rapid and effective access to variously functionalized pyrazolo [1,5-a] pyrimidines derivatives.First, we were explored the study and the application of the condensation of the pyran-2 one with 5(3)-amino-3 (5)-arylpyrazoles whether it is by classic heating or under microwaves. Indeed, we have described the first example of the direct and regioselective palladium-catalyzed (hetero)arylation of 5,7-dimethylpyrazolo[1,5-a]pyrimidine, the reaction may be inducted to occur at either an sp2 or an sp3 carbon atom.The last part of this report was dedicated to the preparation of some 7-substituted pyrazolo[1,5-a]pyrimidines via a one-pot two steps palladium-catalyzed direct CH-arylation followed by a saponification-decarboxylation.

Advisors/Committee Members: Guillaumet, Gérald (thesis director), Essassi, Mokhtar El (thesis director).

Subjects/Keywords: Pyrazolo[1,5-a]pyrimidine; Condensation; Pyran-2-one; Micro-onde; (hétéro)arylation directe; Réactions pallado-catalysées; Arylation intramoléculaire; One-pot; Pyrazolo[1,5-a]pyrimidine; Condensation; Pyran-2-one; Microwave; Direct (hetero)arylation; Palladium-catalyzed reactions; Intramolecular arylation; One-pot

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bassoude, I. (2012). Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity. (Doctoral Dissertation). Orléans; Université Mohammed V-Agdal (Rabat, Maroc). Retrieved from http://www.theses.fr/2012ORLE2025

Chicago Manual of Style (16^th Edition):

Bassoude, Ibtissam. “Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity.” 2012. Doctoral Dissertation, Orléans; Université Mohammed V-Agdal (Rabat, Maroc). Accessed January 27, 2021. http://www.theses.fr/2012ORLE2025.

MLA Handbook (7^th Edition):

Bassoude, Ibtissam. “Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity.” 2012. Web. 27 Jan 2021.

Vancouver:

Bassoude I. Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity. [Internet] [Doctoral dissertation]. Orléans; Université Mohammed V-Agdal (Rabat, Maroc); 2012. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2012ORLE2025.

Council of Science Editors:

Bassoude I. Synthèse de nouveaux dérivés pyrazolo[1,5-a]pyrimidiniques à visée biologique : Synthesis of new pyrazolo[1,5-a]pyrimidinic derivatives aiming at biological activity. [Doctoral Dissertation]. Orléans; Université Mohammed V-Agdal (Rabat, Maroc); 2012. Available from: http://www.theses.fr/2012ORLE2025

15. Zeineddine, Abdallah. Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III).

Degree: Docteur es, Chimie moléculaire, 2017, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2017TOU30308

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Ce travail de thèse porte sur la chimie organométallique des complexes d'or(I) et sur l'étude de leurs réactivités. Plus particulièrement, le travail présenté ici dans… (more)

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Ce travail de thèse porte sur la chimie organométallique des complexes d'or(I) et sur l'étude de leurs réactivités. Plus particulièrement, le travail présenté ici dans ce manuscrit avait pour objectif d'approfondir nos connaissances sur l'impact des ligands utilisés sur la réactivité de l'or vis-à-vis (i) de l'addition oxydante intermoléculaire et (ii) la possibilité de stabiliser des intermédiaires d'or(I) hautement réactifs. Dans la première partie de ce manuscrit, l'addition oxydante intermoléculaire des halogénures d'aryle (iodure et bromure) à des complexes moléculaires d'or(I) a été étudiée en détails. Nous avons pu montrer que cette étape élémentaire de la chimie organométallique, considéré comme impossible avec l'or, était en fait un processus favorable lorsqu'un ligand adéquat est employé, et deux stratégies différentes ont été élaborées. La première consiste à utiliser un ligand bis-phosphine bidenté qui impose une géométrie coudée autour de l'or, tandis que la deuxième stratégie implique l'utilisation d'un ligand hémi-labile bidenté avec des groupements donneurs doux et dur. Les deux stratégies ont été fructueuses, et les complexes d'or(III) issus des réactions d'addition oxydante ont été caractérisés spectroscopiquement et structuralement. Dans la deuxième partie, ayant à notre disposition deux complexes d'or(I) capable d'effectuer l'addition oxydante, nous voulions aller au-delà de cette étape élémentaire. Dans cet objectif, nous avons construit un nouveau cycle catalytique Au(I)/Au(III) impliquant une séquence d'addition oxydante Csp2-X, de Csp2-H auration et d'élimination réductrice, illustrant le premier exemple d'arylation directe d'arènes avec des halogénures d'aryle catalysée à l'or. Enfin, dans la dernière partie, nous avons tenté de stabiliser et de caractériser des intermédiaires d'or(I) très instables, comme le a-oxo carbène d'or(I). Cette espèce hautement électrophile est proposée comme un intermédiaire clés dans des nombreuses transformations catalytiques, mais n'a jamais été isolé ou caractérisé (en solution ou à l'état solide). L'utilisation d'un ligand bis-phosphine bidenté nous a permis de caractériser spectroscopiquement et structuralement le carbène a-oxo d'or(I) pour la première fois. Nous avons ensuite étudié sa réactivité vis-à-vis des réactions d'insertion et de cyclopropanation.

The present work is an organometallic study concerning the chemistry of gold(I) complexes and their reactivity. Of particular interest was to gain further knowledge on the impact of the ligands employed on the reactivity of gold towards (i) the intermolecular oxidative addition of aryl halides and (ii) the possibility of stabilizing high reactive gold(I) intermediates. In the first part of the manuscript, the intermolecular oxidative addition of aryl halides (iodide and bromide) with molecular gold(I) complexes was investigated in detail. We showed that this organometallic elementary step, usually considered to be impossible for gold, is actually a favorable process when an adequate ligand is employed…

Advisors/Committee Members: Bourissou, Didier (thesis director), Amgoune, Abderrahmane (thesis director).

Subjects/Keywords: Chimie de l'or; Addition oxydante; Arylation directe; Carbène a-oxo d'or(I); Gold chemistry; Oxidative addition; Direct arylation; Catalysis; Alpha-oxo gold(I) carbenes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zeineddine, A. (2017). Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III). (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2017TOU30308

Chicago Manual of Style (16^th Edition):

Zeineddine, Abdallah. “Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III).” 2017. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 27, 2021. http://www.theses.fr/2017TOU30308.

MLA Handbook (7^th Edition):

Zeineddine, Abdallah. “Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III).” 2017. Web. 27 Jan 2021.

Vancouver:

Zeineddine A. Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III). [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2017. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2017TOU30308.

Council of Science Editors:

Zeineddine A. Harnessing the reactivity of gold via ligand design : stabilization of reactive intermediates and development of new Au(I)/Au(III) catalytic pathways : Exploitation de la réactivité de l'or via le design des ligands : stabilisation des intermédiaires réactionnels et développement de nouveaux processus catalytiques Au(I)/Au(III). [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2017. Available from: http://www.theses.fr/2017TOU30308

16. M. Dell'Acqua. NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS.

Degree: 2012, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/170500

► The aim of the project of this doctoral thesis is the development of new synthetic strategies for the preparation of heterocyclic and heteropolycyclic compounds of… (more)

▼ The aim of the project of this doctoral thesis is the development of new synthetic strategies for the preparation of heterocyclic and heteropolycyclic compounds of potential interest in biological and pharmacological fields. In particular, we studied new general, flexible and regioselective synthetic approaches to oxygen and nitrogen heterocycles. We showed the versatility of nucleophilic addition/annulation domino reactions of alkyne compounds bearing a proximate nucleophile in the synthesis of heterocyclic systems, such as dihydroisobenzofurans, isoquinolines and naphthyridines. These approaches have been successfully transformed in Pd-catalysed multicomponent processes involving a one-pot coupling/addition/cyclisation sequence starting from the simple building blocks, such as ortho-bromoarylaldehydes, terminal alkynes and methanol or ammonia. In some cases, the reactivity of less reactive alkyne substrates has been enhanced by the catalysis of alkynophilic transition metals, such as gold and silver. In particular, we reported a new silver-catalysed approach to 2-methylisoquinolines and 5-methyl-1,6-naphtyridines by tandem addition/cyclisation of γ-ketoalkynes with ammonia. The domino approach has been also extended to 2-acetyl-N-propargylpyrroles for the synthesis of pyrrolo[1,2-a]pyrazine. In this case TiCl4 revealed to be the best promoter. Microwave heating demonstrated to be able to improve the efficiency of both domino and multicomponent processes. Finally, the project developed at the Institut für Organische und Biomolekulare Chemie in the Georg-August-Universität Göttingen (Germany), under the supervision of Prof. L. Ackermann, concerned with the direct arylations of indoles and pyrroles with differently substituted diaryliodonium salts in the absence of metal catalysts. The protocol proved broadly applicable, thereby enabling C-H bond functionalisations of free (NH)- as well as N-substituted indoles and pyrroles. Advisors/Committee Members: tutor: G. Abbiati, coordinatore: E. Valoti, ABBIATI, GIORGIO, VALOTI, ERMANNO.

Subjects/Keywords: alkynes; heterocycles; domino reaction; multicomponent reaction; microwave-promoted synthesis; direct arylation; ammonia; palladium; gold; silver; Settore CHIM/06 - Chimica Organica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dell'Acqua, M. (2012). NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/170500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dell'Acqua, M.. “NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS.” 2012. Thesis, Università degli Studi di Milano. Accessed January 27, 2021. http://hdl.handle.net/2434/170500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dell'Acqua, M.. “NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS.” 2012. Web. 27 Jan 2021.

Vancouver:

Dell'Acqua M. NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS. [Internet] [Thesis]. Università degli Studi di Milano; 2012. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/2434/170500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dell'Acqua M. NEW SYNTHETIC STRATEGIES FOR THE PREPARATION OF HETEROCYCLIC AND HETEROPOLYCYCLIC COMPOUNDS. [Thesis]. Università degli Studi di Milano; 2012. Available from: http://hdl.handle.net/2434/170500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Grolleau, Jérémie. Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation.

Degree: Docteur es, Chimie, 2016, Angers

URL: http://www.theses.fr/2016ANGE0029

►

Les recherches sur le photovoltaïque organique depuis une dizaine d’année ont permis une constante progression de l’efficacité des cellules solaires. Plusieurs groupes de recherche ont… (more)

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Les recherches sur le photovoltaïque organique depuis une dizaine d’année ont permis une constante progression de l’efficacité des cellules solaires. Plusieurs groupes de recherche ont amorcé une réflexion sur les procédés de synthèse qui permettraient de limiter les déchets. Ainsi le couplage par arylation directe qui évite l’utilisation de dérivés organométalliques a émergé comme alternative au couplage organométallique classique. Une première partie est consacrée à l’étude méthodologique du couplage par arylation directe de la triphénylamine avec des dérivés du thiophène-2- carboxaldéhyde substitués en C3 et C4 par des groupements électro-accepteurs et électro-donneurs. Ce motif de base permet l’accès à trois séries de petites molécules par simple condensation. Des cellules photovoltaïques atteignant des rendements de photo-conversion de 3% en cellules bicouches, ont été obtenues. Dans une deuxième partie, la polymérisation par arylation directe sur des monomères du thiophène substitué par des groupements nitriles comme accepteur et des groupements alcoxy ou thioalkyl comme donneur conduit en une seule étape à une nouvelle famille de polymères conjugués. Ces polymères ont été utilisés comme matériaux donneurs et accepteur dans des cellules. Enfin en dernière partie, un travail exploratoire sur les propriétés d’émission de dérivés du benzofurane a été entrepris. Des réactions de condensation de Knoevenagel ont été développées pour obtenir toute une série de dérivés contenant l’unité cyano-vinylbenzofurane. La plupart des composés présente une forte émission à l’état solide.

Research on organic photovoltaics over a decade allowed a steadily increasing in the efficiency of solar cells. Several research groups have begun a reflection on the synthesis processes to limit wastes. Thus the direct arylation coupling which avoids the use of organometallic compounds, has emerged as an example of green reaction. The first part is devoted to the methodological study of direct arylation of bromotriphenylamine with thiophene-2-carboxaldehyde derivatives substituted in C3 and C4 by electron-withdrawing groups and electron-donor groups. This basic pattern allows access to three small molecules by condensation. Photovoltaic cells reaching photoconversion efficiencies of 3% were obtained. In the second part, the polymerization by direct arylation of sustituted thiophene monomers by nitrile groups as the acceptor and by alkoxy or thioalkyl as the donor led in one step to a novel family of conjugated polymers having donor and acceptor groups alternately. Solar cells were made with the polymers as donors or as acceptors materials. Finally, in the last part, exploratory work on the emission properties of benzofuran derivatives have been made. Knoevenagel condensations have been developed for a range of compounds containing the cyano-vinylbenzofuran unit. Most compounds have high emission in the solid state.

Advisors/Committee Members: Frère, Pierre (thesis director), Legoupy, Stéphanie (thesis director).

Subjects/Keywords: Emission induite par agrégation; Organic semiconducteur; Organic photovoltaics; Direct arylation; Substitued thiophene; Aggregation-Induced emission; Benzofuran; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grolleau, J. (2016). Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation. (Doctoral Dissertation). Angers. Retrieved from http://www.theses.fr/2016ANGE0029

Chicago Manual of Style (16^th Edition):

Grolleau, Jérémie. “Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation.” 2016. Doctoral Dissertation, Angers. Accessed January 27, 2021. http://www.theses.fr/2016ANGE0029.

MLA Handbook (7^th Edition):

Grolleau, Jérémie. “Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation.” 2016. Web. 27 Jan 2021.

Vancouver:

Grolleau J. Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation. [Internet] [Doctoral dissertation]. Angers; 2016. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2016ANGE0029.

Council of Science Editors:

Grolleau J. Synthèse de nouveaux semi-conducteurs organiques par arylation directe : Synthesis of new organic semiconducteurs by direct arylation. [Doctoral Dissertation]. Angers; 2016. Available from: http://www.theses.fr/2016ANGE0029

Florida International University

18. Liang, Yong. Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides.

Degree: PhD, Chemistry, 2014, Florida International University

URL: https://digitalcommons.fiu.edu/etd/1591 ; 10.25148/etd.FI14110716 ; FI14110716

► The antiviral or anticancer activities of C-5 modified pyrimidine nucleoside analogues validate the need for the development of their syntheses. In the first half… (more)

▼ The antiviral or anticancer activities of C-5 modified pyrimidine nucleoside analogues validate the need for the development of their syntheses. In the first half of this dissertation, I explore the Pd-catalyzed cross-coupling reaction of allylphenylgermanes with aryl halides in the presence of SbF₅/TBAF to give various biaryls by transferring multiple phenyl groups, which has also been applied to the 5-halo pyrimidine nucleosides for the synthesis of 5-aryl derivatives. To avoid the use of organometallic reagents, I developed Pd-catalyzed direct arylation of 5-halo pyrimidine nucleosides. It was discovered that 5-aryl pyrimidine nucleosides could be synthesized by Pd-catalyzed direct arylation of N³-free 5-halo uracil and uracil nucleosides with simple arenes or heteroaromatics in the presence of TBAF within 1 h. Both N³-protected and N³-free uracil and uracil nucleosides could undergo base-promoted Pd-catalyzed direct arylation, but only with electron rich heteroaromatics. In the second half of this dissertation, 5-acetylenic uracil and uracil nucleosides have been employed to investigate the hydrogermylation, hydrosulfonylation as well as hydroazidation for the synthesis of various functionalized 5-vinyl pyrimidine nucleosides. Hydrogermylation of 5-alkynyl uracil analogues with trialkylgermane or tris(trimethylsilyl)germane hydride gave the corresponding vinyl trialkylgermane, or tris(trimethylsilyl)germane uracil derivatives. During the hydrogermylation with triphenylgermane, besides the vinyl triphenylgermane uracil derivatives, 5-[2-(triphenylgermyl)acetyl]uracil was also isolated and characterized and the origin of the acetyl oxygen was clarified. Tris(trimethylsilyl)germane uracil derivatives were coupled to aryl halides but with decent yield. Iron-mediated regio- and stereoselective hydrosulfonylation of the 5-ethynyl pyrimidine analogues with sulfonyl chloride or sulfonyl hydrazine to give 5-(1-halo-2-tosyl)vinyluracil nucleoside derivatives has been developed. Nucleophilic substitution of the 5-(β-halovinyl)sulfonyl nucleosides with various nucleophiles have been performed to give highly functionalized 5-vinyl pyrimidine nucleosides via the addition-elimination mechanism. The 5-(β-keto)sulfonyluracil derivative has also been synthesized via the aerobic difunctionalization of 5-ethynyluracil analogue with sulfinic acid in the presence of catalytic amount of pyridine. Silver catalyzed hydroazidation of protected 2'-deoxy-5-ethynyluridine with TMSN₃ in the presence of catalytic amount of water to give 5-(α-azidovinyl)uracil nucleoside derivatives was developed. Strain promoted Click reaction of the 5-(α-azidovinyl)uracil with cyclooctyne provide the corresponding fully conjugated triazole product. Advisors/Committee Members: Stanislaw F. Wnuk, Kevin O'Shea, David Becker, Piero Gardinali, M. Alejandro Barbieri.

Subjects/Keywords: Nucleoside; Pd-catalyzed Cross-coupling; Palladium; Click Chemistry; Hydrogermylation; C-H activation; Direct Arylation; Organic Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liang, Y. (2014). Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/1591 ; 10.25148/etd.FI14110716 ; FI14110716

Chicago Manual of Style (16^th Edition):

Liang, Yong. “Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides.” 2014. Doctoral Dissertation, Florida International University. Accessed January 27, 2021. https://digitalcommons.fiu.edu/etd/1591 ; 10.25148/etd.FI14110716 ; FI14110716.

MLA Handbook (7^th Edition):

Liang, Yong. “Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides.” 2014. Web. 27 Jan 2021.

Vancouver:

Liang Y. Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides. [Internet] [Doctoral dissertation]. Florida International University; 2014. [cited 2021 Jan 27]. Available from: https://digitalcommons.fiu.edu/etd/1591 ; 10.25148/etd.FI14110716 ; FI14110716.

Council of Science Editors:

Liang Y. Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides. [Doctoral Dissertation]. Florida International University; 2014. Available from: https://digitalcommons.fiu.edu/etd/1591 ; 10.25148/etd.FI14110716 ; FI14110716

19. Tan, Yichen. Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide.

Degree: Chemistry, 2013, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/9hz9d488

► This dissertation discusses three studies on the Pd-catalyzed direct functionalization of aromatic C-H bonds. 1) Methods for direct amination are developed. 2) Mechanistic studies on… (more)

Subjects/Keywords: Chemistry; C-H Functionalization; Direct Amination; Direct Arylation; Palladium

…Direct Arylation of Arenes. Direct functionalization of aromatic C-H bonds offers an attractive… …amination and direct arylation, which are the topics of the research described in this thesis… …of initial intermolecular direct arylation, followed by intramolecular direct amination. 5… …and direct arylation,43 13 sterically controlled amination processes that would make this… …two decades, various methods have been developed for the direct arylation of a variety of…

8 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tan, Y. (2013). Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/9hz9d488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tan, Yichen. “Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide.” 2013. Thesis, University of California – Berkeley. Accessed January 27, 2021. http://www.escholarship.org/uc/item/9hz9d488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tan, Yichen. “Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide.” 2013. Web. 27 Jan 2021.

Vancouver:

Tan Y. Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide. [Internet] [Thesis]. University of California – Berkeley; 2013. [cited 2021 Jan 27]. Available from: http://www.escholarship.org/uc/item/9hz9d488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tan Y. Palladium-Catalyzed Direct Functionalization of Aromatic C-H Bonds: Development of Methods for Direct Amination and Mechanistic Studies of Direct Arylation of Benzene and Pyridine N-Oxide. [Thesis]. University of California – Berkeley; 2013. Available from: http://www.escholarship.org/uc/item/9hz9d488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston

20. Nadres, Enrico 1979-. PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES.

Degree: PhD, Chemistry, 2012, University of Houston

URL: http://hdl.handle.net/10657/708

► Palladium-catalyzed functionalization of C–H bonds is becoming an important synthetic tool that allows the preparation of desired substances in fewer steps and higher yields compared… (more)

▼ Palladium-catalyzed functionalization of C–H bonds is becoming an important synthetic tool that allows the preparation of desired substances in fewer steps and higher yields compared to traditional synthetic routes. The C–H bonds can be directly converted to C–C or C–heteroatom bonds. However, the ubiquity of C–H bonds in organic compounds can lead to problems in chemo- and regioselectivity. In heterocycles, the control of regioselectivity of the reaction is governed by the difference in acidity of the heterocyclic ring C–H bonds. An economical method for the arylation of C–H bonds of pyrroles and furans by aryl chlorides was developed. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)biphenyl ligand, and an inorganic base. Electron-rich, electron-poor, and heterocyclic aryl chloride coupling partners can be used and arylated heterocycles are obtained in moderate to good yields. The functionalization of sp2 and sp3 C–H bonds can be promoted by the use of directing groups that coordinate the Pd catalyst and activate the desired C–H functionalities. Use of Pd(OAc)2 in conjunction with cesium acetate or potassium carbonate bases allows functionalization of sp2 and sp3 C–H bonds in amides possessing picolinic acid directing group. Stoichiometric silver additive is not required in contrast with previously published procedure. Arylations are effective for sp2 as well as primary and secondary sp3 C–H bonds. Alkylations of sp2 C–H bonds are successful in most cases. Both primary and secondary alkyl iodides are reactive but secondary alkyl iodides afford low yields. Alkylation of sp2 C–H bonds is low yielding and the reaction requires further optimization. Alkyl and aryl iodides as well as benzyl bromides are reactive. Aryl and alkyl bromides afford no product. Direct conversion of C–H bonds to C–N bonds was also developed. Pd-catalyzed method for pyrrolidine, indoline, and isoindoline formation by cyclization via C–H/N–H coupling is presented. The method employs a picolinamide directing group, PhI(OAc)2 oxidant, and toluene solvent at 80–120 °C. Cyclization is effective for sp2 as well as aliphatic and benzylic sp3 C–H bonds. Advisors/Committee Members: Daugulis, Olafs (advisor), Briggs, James M. (committee member), Cai, Chengzhi (committee member), Miljanić, Ognjen Š. (committee member), Xu, Shoujun (committee member).

Subjects/Keywords: C-H activation; C-H functionalization; Palladium; Catalysis; Arylation; Alkylation; Amination; Heterocycle; Furan; Pyrrole; Aryl chloride; Aryl iodide; Picolinic acid; Picolinamide; Auxiliary-directed; Auxiliary-assisted; Direct functionalization; Direct

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nadres, E. 1. (2012). PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/708

Chicago Manual of Style (16^th Edition):

Nadres, Enrico 1979-. “PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES.” 2012. Doctoral Dissertation, University of Houston. Accessed January 27, 2021. http://hdl.handle.net/10657/708.

MLA Handbook (7^th Edition):

Nadres, Enrico 1979-. “PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES.” 2012. Web. 27 Jan 2021.

Vancouver:

Nadres E1. PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES. [Internet] [Doctoral dissertation]. University of Houston; 2012. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/10657/708.

Council of Science Editors:

Nadres E1. PALLADIUM-CATALYZED C–H BOND FUNCTIONALIZATION OF HETEROCYCLES AND AMINES. [Doctoral Dissertation]. University of Houston; 2012. Available from: http://hdl.handle.net/10657/708

21. Skhiri, Aymen. Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions.

Degree: Docteur es, Chimie, 2017, Rennes 1; Université de Sfax (Tunisie)

URL: http://www.theses.fr/2017REN1S080

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Au cours de cette thèse, nous nous sommes intéressés à la synthèse d’hétérocycles arylés via l’activation de liaisons sp2 C-H d’hétéroaromatiques et à la synthèse… (more)

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Au cours de cette thèse, nous nous sommes intéressés à la synthèse d’hétérocycles arylés via l’activation de liaisons sp2 C-H d’hétéroaromatiques et à la synthèse d’alcènes arylés halo-substitués catalysée par le palladium. Les produits obtenus sont considérés comme des briques moléculaires, intéressantes pour les biochimistes, ainsi que pour la préparation de matériaux. Le système catalytique Pd(MeCN)2Cl2/Li2CO3/dioxane permet l’accès direct à une grande variété de molécules arylées à partir d’hétéroarènes ou d’alcènes et de chlorures de benzènesulfonyle. Nous avons mis au point une méthode permettant l’arylation directe en position β de sélénophènes à partir de sélénophènes et de chlorures de benzènesulfonyle. Nous avons également montré que l’utilisation de chlorures de benzènesulfonyle (poly)halogénés permet de synthétiser par des réactions pallado-catalysées des hétéroarènes arylés, des stilbènes ou des cinnamates (poly)halo-substitués.

In this thesis we have been interested in the synthesis of arylated heterocycles via the activation of sp2 C-H bonds of heteroaromatics and to the synthesis of halo-substituted arylated alkenes using palladium-catalysis. The products obtained are considered to be molecular bricks which are of interest to biochemists as well as to the preparation of materials. The catalyst system Pd(MeCN)2Cl2/Li2CO3/dioxane allows the direct access to a wide variety of arylated molecules from heteroarenes or alkenes and benzenesulfonyl chlorides. We have developed a method for the direct β-arylation of selenophenes from selenophenes and benzenesulfonyl chlorides. We have also shown that the use of (poly)halogenated benzenesulfonyl chlorides makes it possible to synthesize, by Pd-catalyzed reactions, (poly)halo-substituted arylated heteroarenes, stilbenes or cinnamates.

Advisors/Committee Members: Doucet, Henri (thesis director), Ben Salem, Ridha (thesis director).

Subjects/Keywords: Arylations; Activation de la liaison C-H; Réaction du Heck; Palladium; Catalyse; Chlorures benzènesulfonyle; Alcènes; Arylation direct; Selenophènes; Arylations; C-H bond activation; Heck reaction; Palladium; Catalysis; Benzenesulfonyl chlorides; Alkenes; Direct arylation; Selenophenes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Skhiri, A. (2017). Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions. (Doctoral Dissertation). Rennes 1; Université de Sfax (Tunisie). Retrieved from http://www.theses.fr/2017REN1S080

Chicago Manual of Style (16^th Edition):

Skhiri, Aymen. “Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions.” 2017. Doctoral Dissertation, Rennes 1; Université de Sfax (Tunisie). Accessed January 27, 2021. http://www.theses.fr/2017REN1S080.

MLA Handbook (7^th Edition):

Skhiri, Aymen. “Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions.” 2017. Web. 27 Jan 2021.

Vancouver:

Skhiri A. Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions. [Internet] [Doctoral dissertation]. Rennes 1; Université de Sfax (Tunisie); 2017. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2017REN1S080.

Council of Science Editors:

Skhiri A. Réactivité des chlorures de benzènesulfonyle pour l'accès à des hétéroarènes et alcènes arylés via des réactions pallado-catalysées : Reactivity of benzenesulfonyl chlorides for access to heteroarenes and arylated alkenes via palladium-catalyzed reactions. [Doctoral Dissertation]. Rennes 1; Université de Sfax (Tunisie); 2017. Available from: http://www.theses.fr/2017REN1S080

Université de Bordeaux I

22. Naturale, Guillaume. Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions.

Degree: Docteur es, Chimie organique, 2012, Université de Bordeaux I

URL: http://www.theses.fr/2012BOR14635

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Dans le cadre d’un programme de recherche dédié à la découverte de petites molécules à visée anticancéreuse, nous avons envisagé de concevoir des composés originaux… (more)

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Dans le cadre d’un programme de recherche dédié à la découverte de petites molécules à visée anticancéreuse, nous avons envisagé de concevoir des composés originaux dérivés de quinones. Notre premier objectif a été d’élaborer des mimes non-peptidiques de la protéine Smac, susceptibles de participer à relancer le phénomène d’apoptose, dont la structure est rigidifiée par des contraintes conformationnelles. Par ailleurs, les kinases et les phosphatases, jouant des rôles complémentaires de phosphorylation / déphosphorylation dans le cadre du contrôle du cycle cellulaire notamment, apparaissent aussi comme des cibles intéressantes. Une étude attentive de leurs inhibiteurs connus nous a permis de mettre en avant des analogies structurales qui nous ont conduit à vouloir synthétiser des motifs fonctionnalisés de dérivés de naphtoquinones.L’introduction directe de chaînes latérales aliphatiques sur nos substrats, par création de liaisons de type C(sp2)–C(sp3), a été rendue possible grâce au développement d’une méthodologie de décarboxylation radicalaire. Dans les conditions réactionnelles mises au point, le couple Ag(I)/S2O82- est utilisé comme initiateur radicalaire et autorise la génération de radicaux alkyles par décarboxylation d’acides aminés. L’introduction directe de cycles aromatiques fonctionnalisés, via la création de liaisons de type C(sp2)–C(sp2), a été réalisée par l’intermédiaire de la génération de radicaux aryles issus de sels de diazonium stables ou d’anilines. Les procédés décrits dans ce manuscrit nous ont permis d’apporter certains éclaircissements sur la réactivité des substrats et sur les mécanismes réactionnels impliqués.

In our ongoing course dedicated to the discovery of small anticancer molecules, we designed novel quinone derivatives. Our first objective was to fashion non-peptidic Smac mimics, able to trigger apoptosis in tumor cells, displaying a structure rigidified by conformational restrictions. Otherwise, the kinases and the phosphatases, acting as phosphorylating / dephosphorylating agents mostly in the control of the cell cycle, were thought to be other relevant biological targets. An intent study of their known inhibitors allowed us to underline trends in their chemical structure and made us plan the synthesis of functionalized naphthoquinones.A dedicated approach involving radical decarboxylation of amino acids allowed the introduction of aliphatic side chains on our substrates though C(sp2)–C(sp3) bond formation. Ag(I)/S2O82- was used as alkyl radical initiator and the direct C-H alkylation of the quinonic positions could take place. C(sp2)–C(sp2) bonds were created through aryl radicals generation from stable diazonium salts or anilines which allowed the direct C-H arylation of quinones. The procedures described along this manuscript let us formulate several advances on the substrates reactivity and on the reaction mechanisms involved.

Advisors/Committee Members: Dessolin, Jean (thesis director), Felpin, François-Xavier (thesis director).

Subjects/Keywords: Quinones; Chimie Médicinale; Agents Anticancéreux; Réactions Radicalaires; Alkylation Directe; Arylation Directe; Acides Aminés; Sels de Diazonium; Anilines; Quinones; Medicinal Chemistry; Anticancer Agents; Radical Reactions; C-H Direct Alkylation; C-H Direct Arylation; Amino Acids; Diazonium Salts; Anilines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Naturale, G. (2012). Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions. (Doctoral Dissertation). Université de Bordeaux I. Retrieved from http://www.theses.fr/2012BOR14635

Chicago Manual of Style (16^th Edition):

Naturale, Guillaume. “Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions.” 2012. Doctoral Dissertation, Université de Bordeaux I. Accessed January 27, 2021. http://www.theses.fr/2012BOR14635.

MLA Handbook (7^th Edition):

Naturale, Guillaume. “Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions.” 2012. Web. 27 Jan 2021.

Vancouver:

Naturale G. Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions. [Internet] [Doctoral dissertation]. Université de Bordeaux I; 2012. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2012BOR14635.

Council of Science Editors:

Naturale G. Approches radicalaires pour la fonctionnalisation directe de quinones à visée anticancereuse : Direct functionalization of anticancer quinones through radical reactions. [Doctoral Dissertation]. Université de Bordeaux I; 2012. Available from: http://www.theses.fr/2012BOR14635

23. Cohen Potier de Courcy, Anita. Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures.

Degree: Docteur es, Sciences, 2012, Aix Marseille Université

URL: http://www.theses.fr/2012AIXM5503

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L'objectif de ce travail consiste en la synthèse et l'évaluation antiparasitaire in vitro de nouveaux dérivés du thiazole et apparentés. Plusieurs stratégies de synthèse visant… (more)

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L'objectif de ce travail consiste en la synthèse et l'évaluation antiparasitaire in vitro de nouveaux dérivés du thiazole et apparentés. Plusieurs stratégies de synthèse visant à une pharmacomodulation en séries mono- et polycycliques ont été étudiées : en série 2-méthyl-5-nitrothiazole, la pharmacomodulation anti-Trichomonas de la position 4 par stratégie SRN1 n'a pas permis d'améliorer l'activité déjà démontrée en série 2-méthyl-5-nitroimidazole, mais a conduit à des dérivés à activité antiproliférative in vitro, spécifique de la lignée HepG2. En série 4-arylsulfonylméthyl-2-méthylthiazole, la pharmacomodulation de la position 5, par couplage de Suzuki-Miyaura d'une part, et par arylation directe et réaction de Knoevenagel intramoléculaire d'autre part, a conduit à des dérivés mono- et polycycliques dont certains ont démontré une activité antiplasmodiale in vitro encourageante. En série 5H-thiazolo[3,2-a]pyrimidin-5-one, la réaction de double couplage de Suzuki-Miyaura a révélé l'importance du groupement phényle en position 6 pour l'activité antiplasmodiale de ces dérivés. Enfin, l'évaluation biologique in vitro de thiéno[3,2-d]pyrimidin-4(3H)-ones a permis de caractériser le pharmacophore responsable de l'activité antiplasmodiale significative de cette série. Les résultats préliminaires encourageants d'une étude mécanistique antiplasmodiale présentent l'inhibition spécifique des kinases plasmodiales comme un mécanisme d'action potentiel de ces composés.

The objective of this work consists of the synthesis and the antiparasitic in vitro evaluation of new thiazole derivatives and related structures. Several synthetic strategies aiming at the pharmacomodulation on mono- and polycyclic series have been studied: in 2-methyl-5-nitrothiazole series, the anti-Trichomonas pharmacomodulation on position 4 by SRN1 strategy did not improve the activity previously demonstrated in 2-methyl-5-nitroimidazole series, but led to derivatives displaying a selective in vitro antiproliferative activity toward the HepG2 cell line. In 4-arylsulfonylmethyl-2-methylthiazole series, the pharmacomodulation on position 5, by Suzuki-Miyaura cross-coupling reaction on the one hand, and by direct arylation and intramolecular Knoevenagel reaction on the other hand, led to mono- and polycyclic derivatives among which some displayed an encouraging in vitro antiplasmodial activity. In 5H-thiazolo[3,2-a]pyrimidin-5-one series, a double Suzuki-Miyaura cross-coupling reaction revealed that the phenyl group on position 6 contributes to the antiplasmodial effect of this series. Finally, the in vitro biological evaluation of the thieno[3,2-d]pyrimidin-4(3H)-one scaffold let to characterize the pharmacophore responsible for the significant antiplasmodial activity. Some preliminary encouraging results regarding a mechanistic antiplasmodial study show the specific inhibition of plasmodial kinases, as a potential mechanism of action of some of these compounds.

Advisors/Committee Members: Vanelle, Patrice (thesis director), Rathelot, Pascal (thesis director).

Subjects/Keywords: Thiazole; Plasmodium falciparum; Activité antiproliférative in vitro; Activité antiplasmodiale in vitro; Pharmacomodulation; Kinases plasmodiales; Srn1; Palladium; Couplage de Suzuki-Miyaura; Arylation directe; Thiazole; Plasmodium falciparum; In vitro antiproliferative activity; In vitro antiplasmodial activity; Pharmacomodulation; Plasmodial kinases; Srn1; Palladium; Suzuki-Miyaura cross-coupling; Direct arylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cohen Potier de Courcy, A. (2012). Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2012AIXM5503

Chicago Manual of Style (16^th Edition):

Cohen Potier de Courcy, Anita. “Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures.” 2012. Doctoral Dissertation, Aix Marseille Université. Accessed January 27, 2021. http://www.theses.fr/2012AIXM5503.

MLA Handbook (7^th Edition):

Cohen Potier de Courcy, Anita. “Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures.” 2012. Web. 27 Jan 2021.

Vancouver:

Cohen Potier de Courcy A. Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures. [Internet] [Doctoral dissertation]. Aix Marseille Université 2012. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2012AIXM5503.

Council of Science Editors:

Cohen Potier de Courcy A. Synthèse et évaluation antiparasitaire de nouveaux dérivés du thiazole et apparentés : Synthesis and antiparasitic evaluation of new thiazole derivatives and related structures. [Doctoral Dissertation]. Aix Marseille Université 2012. Available from: http://www.theses.fr/2012AIXM5503

24. Huang, Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.

Degree: 2015, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/324941 ; URN:NBN:NL:UI:10-1874-324941 ; 1874/324941 ; urn:isbn:9789039364697 ; URN:NBN:NL:UI:10-1874-324941 ; https://dspace.library.uu.nl/handle/1874/324941

► In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations… (more)

▼ In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations catalyzed by Fe, Co, Ni and Cu are mainly demonstrated and discussed. Chapter 2 described a pre-made iron-based catalytic system that is able to catalyze the direct arylation reaction between aryl halides and unactivated arenes under aerobic conditions and using non-distilled benzene as solvent and reagent. Chapter 3 focuses on unraveling structural information of the FPsystem and acquiring an understanding of the evolution of iron species during the direct arylation reactions. By employing a combination of IR, UV-Vis and XAS (XANES and EXAFS) techniques, together with the information from elemental analysis and ICP-OES, a conclusion can be draw that the main component in different FPE systems is almost the same, while in FPM systems (generated in methanol) these are quite different. The constitution of the main component in FP2Eand FP1M was proposed to be [Fe(phen)Cl3(CH3CH2OH)]∙0.5CH3CH2OH ∙0.5phen and [Fe(phen)2Cl2][FeCl4], respectively. Further investigation of FP2Esystems was performed in Chapter 4. First, a kinetic study of the FP2Ecatalyzed direct aryaltion of 4-iodoanisole and benzene in air under reflux was carried out. The comparison of catalytic reactivity of FPE and FPM systems were carried out in this chapter, too. In Chapter 5 the application of FP2E in the Heck-type reaction between 4-iodoanisole and styrene in air was investigated. However, initial results showed that the combination of the applied base and alcohol additive is able to catalyze such transformations in air albeit with moderate yield (58%). Following the observation, the effects of base, alcohol additive, and solvent on the air tolerance of this kind of reaction were investigated in this chapter. The employment of KOtBu and DMF proved to be crucial to the success of the Heck-type reaction in air with non-distilled solvent. A possible mechanism was proposed, which involves radical intermediates formed from the reaction between KOtBu and DMF. Advisors/Committee Members: Klein Gebbink, Bert, Moret, Marc-Etienne.

Subjects/Keywords: iron; direct arylation; air tolerant; kinetic study; Heck reaction; radical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, Y. (2015). Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/324941 ; URN:NBN:NL:UI:10-1874-324941 ; 1874/324941 ; urn:isbn:9789039364697 ; URN:NBN:NL:UI:10-1874-324941 ; https://dspace.library.uu.nl/handle/1874/324941

Chicago Manual of Style (16^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Doctoral Dissertation, University Utrecht. Accessed January 27, 2021. https://dspace.library.uu.nl/handle/1874/324941 ; URN:NBN:NL:UI:10-1874-324941 ; 1874/324941 ; urn:isbn:9789039364697 ; URN:NBN:NL:UI:10-1874-324941 ; https://dspace.library.uu.nl/handle/1874/324941.

MLA Handbook (7^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Web. 27 Jan 2021.

Vancouver:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Internet] [Doctoral dissertation]. University Utrecht; 2015. [cited 2021 Jan 27]. Available from: https://dspace.library.uu.nl/handle/1874/324941 ; URN:NBN:NL:UI:10-1874-324941 ; 1874/324941 ; urn:isbn:9789039364697 ; URN:NBN:NL:UI:10-1874-324941 ; https://dspace.library.uu.nl/handle/1874/324941.

Council of Science Editors:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Doctoral Dissertation]. University Utrecht; 2015. Available from: https://dspace.library.uu.nl/handle/1874/324941 ; URN:NBN:NL:UI:10-1874-324941 ; 1874/324941 ; urn:isbn:9789039364697 ; URN:NBN:NL:UI:10-1874-324941 ; https://dspace.library.uu.nl/handle/1874/324941

Université de Montréal

25. Ladd, Carolyn L. Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis.

Degree: 2014, Université de Montréal

URL: http://hdl.handle.net/1866/10665

Subjects/Keywords: Palladium; Silver; Direct arylation; Direct functionalization; Cyclopropanes; Catalysis; Benzoazepinones; Spirooxindoles; Argent; Arylation directe; Fonctionnalisation directe; Catalyse; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ladd, C. L. (2014). Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/10665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ladd, Carolyn L. “Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis.” 2014. Thesis, Université de Montréal. Accessed January 27, 2021. http://hdl.handle.net/1866/10665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ladd, Carolyn L. “Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis.” 2014. Web. 27 Jan 2021.

Vancouver:

Ladd CL. Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis. [Internet] [Thesis]. Université de Montréal; 2014. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1866/10665.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ladd CL. Intramolecular Direct Functionalization of Cyclopropanes via Silver-Mediated, Palladium Catalysis. [Thesis]. Université de Montréal; 2014. Available from: http://hdl.handle.net/1866/10665

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Grosse, Sandrine. Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation.

Degree: Docteur es, Chimie organique, 2013, Université d'Orléans

URL: http://www.theses.fr/2013ORLE2056

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Les imidazo[1,2-b]pyrazoles tout comme les imidazo[1,2-a]imidazoles sont des entités présentant diverses applications intéressantes notamment dans le domaine pharmacologique. Cependant, malgré ce potentiel, ces structures hétérobicycliques… (more)

Subjects/Keywords: Imidazo[1,2-b]pyrazoles; Imidazo[1,2-a]imidazoles; Imidazo[1,2-a]imidazolin-2-ones; (hétéro)arylation directe; Metallo-catalysées; Régioselectivité; Suzuki-Miyaura; Micro-ondes; Imidazo[1,2-b]pyrazoles; Imidazo[1,2-a]imidazoles; Imidazo[1,2-a]imidazolin-2-ones; Direct (hetero)arylation; Metallo-catalysed reactions; Regioselectivity; Suzuki-Miyaura; Micro-waves

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grosse, S. (2013). Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2013ORLE2056

Chicago Manual of Style (16^th Edition):

Grosse, Sandrine. “Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation.” 2013. Doctoral Dissertation, Université d'Orléans. Accessed January 27, 2021. http://www.theses.fr/2013ORLE2056.

MLA Handbook (7^th Edition):

Grosse, Sandrine. “Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation.” 2013. Web. 27 Jan 2021.

Vancouver:

Grosse S. Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation. [Internet] [Doctoral dissertation]. Université d'Orléans; 2013. [cited 2021 Jan 27]. Available from: http://www.theses.fr/2013ORLE2056.

Council of Science Editors:

Grosse S. Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique : Imidazo[1,2-b]pyrazoles, imidazo[1,2-a]imidazoles : synthesis, functionalisation and biological evaluation. [Doctoral Dissertation]. Université d'Orléans; 2013. Available from: http://www.theses.fr/2013ORLE2056

Université de Montréal

27. Mousseau, James J. Direct functionalization of heterocyclic and non-heterocyclic arenes.

Degree: 2011, Université de Montréal

URL: http://hdl.handle.net/1866/4893

Subjects/Keywords: Ylures de N-iminopyridinium; arylation directe; vinylation; catalyse; palladium; cuivre; fer; groupement directeur; N-Iminopyridinium ylides; direct arylation; alkenylation; catalysis; palladium; copper; iron; directing group; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mousseau, J. J. (2011). Direct functionalization of heterocyclic and non-heterocyclic arenes. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/4893

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mousseau, James J. “Direct functionalization of heterocyclic and non-heterocyclic arenes.” 2011. Thesis, Université de Montréal. Accessed January 27, 2021. http://hdl.handle.net/1866/4893.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mousseau, James J. “Direct functionalization of heterocyclic and non-heterocyclic arenes.” 2011. Web. 27 Jan 2021.

Vancouver:

Mousseau JJ. Direct functionalization of heterocyclic and non-heterocyclic arenes. [Internet] [Thesis]. Université de Montréal; 2011. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1866/4893.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mousseau JJ. Direct functionalization of heterocyclic and non-heterocyclic arenes. [Thesis]. Université de Montréal; 2011. Available from: http://hdl.handle.net/1866/4893

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

28. Ladd, Carolyn L. Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs.

Degree: 2018, Université de Montréal

URL: http://hdl.handle.net/1866/20442

Subjects/Keywords: palladium; arylation; alkenylation; ring-opening; direct functionalization; cyclopropanes; asymmetric catalysis; heterocycles; indolines; tetrahydroisoquinolones; Alcénylation; Fonctionnalisation des liaisons C–H; Catalyse asymétrique; Hétérocycles; Tétrahydroquinolones; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ladd, C. L. (2018). Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/20442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ladd, Carolyn L. “Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs.” 2018. Thesis, Université de Montréal. Accessed January 27, 2021. http://hdl.handle.net/1866/20442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ladd, Carolyn L. “Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs.” 2018. Web. 27 Jan 2021.

Vancouver:

Ladd CL. Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs. [Internet] [Thesis]. Université de Montréal; 2018. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1866/20442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ladd CL. Palladium-Catalyzed intramolecular sp3 C–H functionalization : studies in cyclopropyl and heterocyclic motifs. [Thesis]. Université de Montréal; 2018. Available from: http://hdl.handle.net/1866/20442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

29. Vallée, Frédéric. Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées.

Degree: 2010, Université de Montréal

URL: http://hdl.handle.net/1866/4409

Subjects/Keywords: Insertion C-H; Activation C-H; Catalyseur de fer; Catalyseur de palladium; Synthèse de biphényles; Mécansime radicalaire; Direct arylation; Iron catalysis; C-H bond functionalization; Radical transfer; Biaryls synthesis; Palladium catalysis; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vallée, F. (2010). Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/4409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vallée, Frédéric. “Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées.” 2010. Thesis, Université de Montréal. Accessed January 27, 2021. http://hdl.handle.net/1866/4409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vallée, Frédéric. “Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées.” 2010. Web. 27 Jan 2021.

Vancouver:

Vallée F. Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées. [Internet] [Thesis]. Université de Montréal; 2010. [cited 2021 Jan 27]. Available from: http://hdl.handle.net/1866/4409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vallée F. Synthèse de motifs biarylés : fonctionnalisation directe catalysée par des métaux de transition d’espèces aromatiques non activées. [Thesis]. Université de Montréal; 2010. Available from: http://hdl.handle.net/1866/4409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Svensson Akusjärvi, Emma. Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-209

► Reaktionsgeschwindigkeiten der katalytischen Reaktionen zwischen Pyridin-N-Oxiden und Bromaromaten: Die direkte Arylierung von 4-substituierten Pyridin-N-oxiden mit Bromaromaten ergibt Arylpyridin- N-oxide in Ausbeuten von 70-80%. Jedoch ergeben… (more)

▼ Reaktionsgeschwindigkeiten der katalytischen Reaktionen zwischen Pyridin-N-Oxiden und Bromaromaten: Die direkte Arylierung von 4-substituierten Pyridin-N-oxiden mit Bromaromaten ergibt Arylpyridin- N-oxide in Ausbeuten von 70-80%. Jedoch ergeben analoge Arylierungsreaktionen zwischen 2-Brompyridinen und Pyridin-N-oxiden, welche elektronschiebende Substituenten tragen, Kreuzkupplungsprodukte in niedrigeren Ausbeuten von 23-49%. Hingegen bilden Arylierungen von Pyridin-N-oxiden, welche elektronziehende Substituenten tragen, mit 2-Brompyridinen die Pyridin- N-oxidprodukte in 70% Ausbeute. Frühere Berichte über den Mechanismus erklären nicht diese Substratabhängigkeit, weshalb die Geschwindigkeiten der Substratverbräuche und Produktbildungen für die Reaktionen von fünf 4-substituierten Pyridin-N-oxiden mit 2-Brompyridin und Brombenzol bestimmt wurden. Die Reaktionen mit beiden Arylhalogeniden zeigten, dass elektronarme Pyridin- N-oxide eine höhere Reaktivität gegenüber C-H-Aktivierung aufweisen und bilden das Kreuzkupplungsprodukt schneller als elektronreiche N-oxide. Als Nebenreaktion wurde eine konkurrierende Homokupplung des Arylhalogenids identifiziert, wodurch 2,2ʹ-Bipyridin bzw. Biphenyl gebildet wird. Wo die Ausbeute des Kreuzkupplungsprodukts niedrig war, ergab die Homokupplung des 2-Brompyridins Bipyridin in bis zu 35% Ausbeute. Die Homokupplung von Brombenzol zu Biphenyl wurde in signifikant niedrigeren Ausbeuten von <10% beobachtet. Im Vergleich zum Brombenzol, wurde eine schnellere Verbrauchsrate mit 2-Brompyridin beobachtet und dessen Ursprung dem konkurrierenden Homokupplungsmechanismus zugeschrieben. Als zusätzliche Nebenreaktion wurde die Homokupplung des Pyridin-N-oxidsubstrats identifiziert. Homokupplungsprodukte des Arylhalogenids und des Pyridin-N-oxids wurden in jeder Reaktionen in ähnlichen Ausbeuten erhalten, was darauf hindeutet, dass beide Nebenreaktionen durch miteinander verbundene Redoxzyklen ablaufen. Potentiell inhibierende Effekte durch die stickstoffhaltigen Verbindungen, welche in der Reaktionsmischung vorhanden sind, wurden untersucht. Mit der Zugabe von Pyridin, Bipyridin oder Bipyridin-N-oxid wurden langsamere Bildungsgeschwindigkeiten der Kreuzkupplungsprodukte beobachtet. Jedoch sanken die Ausbeuten nicht signifikant, was ausschließt, dass die Inhibierung durch das Substrat oder durch das Produkt für das Absenken der Ausbeuten in Reaktionen mit 2-Brompyridin verantwortlich ist. Synthese und Reaktivität von Arylpalladiumkomplexen in der direkten Arylierung von Pyridin-N-Oxiden: Um die Reaktivität von Arylpalladiumkomplexen in der direkten Arylierung von Pyridin-N-oxiden zu untersuchen, wurden die vorgeschlagenen Intermediate synthetisiert. Ein 6-tert-Butyl- 2-pyridylpalladium(II)bromidkomplex, welcher ein P(t-Bu)3-Ligand trägt, wurde synthetisiert und mittels Röntgenstrukturanalyse charakterisiert, was einen ungewöhnlichen η2-C,N-Bindungsmodus des Pyridylliganden aufdeckte. Zum Vergleich wurde ein 3-Methylphenylpalladium(II)komplex, an dem… Advisors/Committee Members: female (gender), Tzschucke, Carl Christoph (firstReferee), Müller, Christian (furtherReferee).

Subjects/Keywords: C–H bond activation; direct arylation; 2,2'-bipyridine; Suzuki-Miyaura reaction; pyridyl palladium complex; pyridine N-oxide; 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

…Synthesis and Reactivity of Aryl Palladium Complexes in the Direct Arylation of Pyridine… …4 1.2.2 Direct arylation of pyridine N-oxides with halobenzenes… …5 1.2.3 Direct arylation of pyridine N-oxides with heteroaryl halides… …7 1.2.4 Previous mechanistic studies on the direct arylation of pyridine N-oxides… …36 2 Synthesis and Reactivity of Aryl Palladium Complexes in the Direct Arylation of…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Svensson Akusjärvi, E. (2018). Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svensson Akusjärvi, Emma. “Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds.” 2018. Thesis, Freie Universität Berlin. Accessed January 27, 2021. http://dx.doi.org/10.17169/refubium-209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svensson Akusjärvi, Emma. “Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds.” 2018. Web. 27 Jan 2021.

Vancouver:

Svensson Akusjärvi E. Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Jan 27]. Available from: http://dx.doi.org/10.17169/refubium-209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svensson Akusjärvi E. Mechanistic Investigations of the Direct Arylation of Pyridine N-oxides with Bromoarenes and Structure-Reactivity Relationship of Aryl Palladium Complexes in Transmetalations with Organoboron Compounds. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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