subject:(Diagnostic imaging)

University of Hong Kong

1. Chang, Yiu-chuen. Super resolution technique and its potential usage in medical imaging.

Degree: Master of Medical Sciences, 2014, University of Hong Kong

URL: Chang, Y. [張耀泉]. (2014). Super resolution technique and its potential usage in medical imaging. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204647 ; http://dx.doi.org/10.5353/th_b5204647 ; http://hdl.handle.net/10722/198844

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Purpose: Medical imaging systems are used to scan patients to obtain valuable information for diseases diagnosis and assisting treatment. An ideal scanner should be sensitive… (more)

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Purpose: Medical imaging systems are used to scan patients to obtain valuable information for diseases diagnosis and assisting treatment. An ideal scanner should be sensitive enough to detect any trace amount of abnormal tissue at its early stage. With the continuous development of high-tech treatment systems such as Tomotherapy (manufactured by Tomo HD), the high-resolution imaging system is favorable to reduce the damage of normal tissue due to the image guidance of Mega-voltage beam before treatment. In this study, a software approach was presented to improve image resolution without hardware upgrade of a scanner. Methodology A programming technique “Super Resolution Technique” was used and demonstrated in an example of CT. It utilized several similar images with known relative shifts between them. (They can be positional or angular shifted and taken at the same time frame as far as possible). Those images are of low resolution and can be reconstructed to form a higher resolution image. A Super Resolution program was written by MATLAB to prove the method. The experiments 1 to 4 were purely computer-based simulations and experiment 5 used a LightSpeed VCT scanner for real scans. For the computer-based experiments, a few low resolution images have been attempted and registration steps were explored for image reconstruction. A resolution target, USAF1951, was called from MATLAB and used to examine the resolving power before and after image processing based on Super Resolution algorithm. Image-image subtraction was used to compare pre-processing and post-processing images. The number of non-zero pixels was used to access the percentage of similarity. For the experiment using LightSpeed VCT scanner, a GE VCT QA phantom was used to test the performance of the technique. Result From the experiments using USAF1951, it was found that: the minimum resolvable line pairs had improved from family -1 element 6 to family 0 element 2 (2 elements improvement) after applying “Super Resolution Technique” as shown in the experiment 1. An xy directional shifting of the pre-processing images resulted in a better reconstructed image than x-axis shifting or y-axis shifting in terms of resolution, shown in the experiment 2. The experiment 3 concluded that the more the pre-processing images, the better the reconstructed image would be. The experiment 4 showed that the shifts of pre-processing images greater than the detector size could still result in a higher resolution image. The experiment 5 revealed that applying “Super Resolution Technique” to a real CT scanner could not give an obvious improvement in resolution, but the image background noise had reduced. Conclusion It was concluded that the “Super Resolution Technique” could improve the image resolution and reduce the background noise at expense of more imaging time and more dose from the additional view. In case of hardware upgrade of imaging device is not practicable, Super Resolution could help improve the image quality.

published_or_final_version

Medical…

Subjects/Keywords: Diagnostic imaging

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APA (6^th Edition):

Chang, Y. (2014). Super resolution technique and its potential usage in medical imaging. (Masters Thesis). University of Hong Kong. Retrieved from Chang, Y. [張耀泉]. (2014). Super resolution technique and its potential usage in medical imaging. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204647 ; http://dx.doi.org/10.5353/th_b5204647 ; http://hdl.handle.net/10722/198844

Chicago Manual of Style (16^th Edition):

Chang, Yiu-chuen. “Super resolution technique and its potential usage in medical imaging.” 2014. Masters Thesis, University of Hong Kong. Accessed February 16, 2020. Chang, Y. [張耀泉]. (2014). Super resolution technique and its potential usage in medical imaging. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204647 ; http://dx.doi.org/10.5353/th_b5204647 ; http://hdl.handle.net/10722/198844.

MLA Handbook (7^th Edition):

Chang, Yiu-chuen. “Super resolution technique and its potential usage in medical imaging.” 2014. Web. 16 Feb 2020.

Vancouver:

Chang Y. Super resolution technique and its potential usage in medical imaging. [Internet] [Masters thesis]. University of Hong Kong; 2014. [cited 2020 Feb 16]. Available from: Chang, Y. [張耀泉]. (2014). Super resolution technique and its potential usage in medical imaging. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204647 ; http://dx.doi.org/10.5353/th_b5204647 ; http://hdl.handle.net/10722/198844.

Council of Science Editors:

Chang Y. Super resolution technique and its potential usage in medical imaging. [Masters Thesis]. University of Hong Kong; 2014. Available from: Chang, Y. [張耀泉]. (2014). Super resolution technique and its potential usage in medical imaging. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5204647 ; http://dx.doi.org/10.5353/th_b5204647 ; http://hdl.handle.net/10722/198844

Rutgers University

2. Patel, Khushbu Dipak. Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.

Degree: MS, Biomedical Engineering, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/

► In vivo fluorescence imaging is an emerging technique with potential for usage in non-invasive cancer screening, surveillance, real-time surgical guidance, and staging. Fluorescence imaging uses… (more)

▼ In vivo fluorescence imaging is an emerging technique with potential for usage in non-invasive cancer screening, surveillance, real-time surgical guidance, and staging. Fluorescence imaging uses the interaction of non-ionizing optical radiation with endogenous fluorophores or fluorescent labels to provide real-time wide-field images of tissue structure and/or functional components. When imaging in vivo, excitation light must travel through overlying tissue to reach the fluorescent target and emitted fluorescence must then propagate back through the overlying tissue in order to be imaged onto a camera. Recently, fluorescent contrast agents have been developed with excitation and emission wavelengths in the near infrared (NIR) spectrum (~700 – 1,000 nm) in order to minimize attenuation and maximize the measured signal from tissue. While several clinical trials have shown the potential benefits of NIR contrast agents over visible fluorophores, there may still be room for improvement by moving to even longer wavelengths. As scattering is reduced as wavelength increases, some researchers are investigating fluorophores that emit in the short-wave infrared (SWIR) wavelength region (~1,000 – 2,300 nm). This study focuses on examining optical transmission and image contrast at NIR wavelengths and SWIR wavelengths to determine which wavelength region may be optimal for development of fluorescent contrast agents. Transmission and contrast measurements were performed on both tissue simulating phantoms and real biological tissues using 780 nm, 980 nm, and 1550 nm wavelengths. From the experiments conducted, it appears that fluorophore emissions should be chosen based on the goals of the specific application. For an application that requires simple detection of signal, near infrared wavelengths will be better as they can be detected with higher signal levels. For an application that focuses on imaging fluorophore-labeled tissues, short-wave infrared wavelengths will be the better option as they provided better image contrast Advisors/Committee Members: Pierce, Mark C. (chair), School of Graduate Studies.

Subjects/Keywords: Diagnostic imaging

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APA (6^th Edition):

Patel, K. D. (2017). Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/55614/

Chicago Manual of Style (16^th Edition):

Patel, Khushbu Dipak. “Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.” 2017. Masters Thesis, Rutgers University. Accessed February 16, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/55614/.

MLA Handbook (7^th Edition):

Patel, Khushbu Dipak. “Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.” 2017. Web. 16 Feb 2020.

Vancouver:

Patel KD. Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. [Internet] [Masters thesis]. Rutgers University; 2017. [cited 2020 Feb 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/.

Council of Science Editors:

Patel KD. Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. [Masters Thesis]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/

Rutgers University

3. Dumas, John Paul, 1991-. Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems.

Degree: PhD, Biomedical Engineering, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/61734/

► Compressed sensing (CS) is a signal processing technique that provides a theoretical framework for accurately reconstructing discrete signals from fewer samples than traditionally dictated by… (more)

▼ Compressed sensing (CS) is a signal processing technique that provides a theoretical framework for accurately reconstructing discrete signals from fewer samples than traditionally dictated by the Shannon-Nyquist theorem. In the context of imaging, CS enables the recovery of images with more resolved points than pixels in the physical sensor. This capability is appealing for minimally invasive biomedical imaging applications that suffer from poor image quality due to inherent constraints on the size and type of hardware that can be used. The goal of this dissertation is to adapt the CS framework for use in endoscopy platforms, providing a path toward higher resolution minimally invasive imaging. Endoscopes commonly use coherent fiber optic bundles to facilitate in vivo imaging. The image quality with these fiber-bundle-based endoscopes is limited because of manufacturing challenges that restrict achievable fiber density and spacing. Chapter 1 reviews endoscopy technologies and current fiber-bundle- based imaging techniques. The general field of computational imaging is then discussed, including a specific focus on CS-based and spectral imaging approaches that may overcome limitations in fiber bundle imaging. Chapter 2 identifies and addresses some practical challenges that are not anticipated by CS theory or simulations. Computational imaging based on the CS framework, or compressive imaging (CI), was evaluated with a test platform that introduced intensity modulation at a conjugate image plane. It was demonstrated that a CS model accounting for system-specific practical limitations, like optical aberration, is an efficient way to implement highly parallel CI. An imaging architecture with intensity modulation at a conjugate image plane is one approach for CI, but the development of different CS mathematical models has given rise to various different CI architectures. Chapter 3 provides a comparison of different architectures with the application of endoscopy in mind. An experimental comparison of two candidate architectures was performed, and it was determined that an architecture with coded masks at a conjugate image plane is a good option for translation to endoscopy. Chapters 2 and 3 developed imaging methods for CI in test platforms where image quality was limited by the number of pixels in a low-resolution sensor. Chapter 4 translates these methods for fiber-bundle-based imaging where image quality is limited by the number of fibers in an imaging bundle. The fiber bundle was considered as a low-resolution sensor array where the number of resolved points in an image is limited by the number of fibers in the bundle. CI was evaluated in a fiber-bundle-based imaging platform for compressive endoscopy, which was demonstrated for fluorescence imaging and resolved 17 points for each fiber in the bundle. While CI resolves multiple pixels within the diameter of each fiber in thebundle, inter-fiber cladding that binds fibers together blocks information that is not recovered by traditional CI methods. Chapter 4 presents a… Advisors/Committee Members: Pierce, Mark C (chair), Boustany, Nada N (internal member), Hacihaliloglu, Ilker (internal member), Bajwa, Waheed U (outside member), School of Graduate Studies.

Subjects/Keywords: Computational imaging; Endoscopy; Diagnostic imaging

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APA (6^th Edition):

Dumas, John Paul, 1. (2019). Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/61734/

Chicago Manual of Style (16^th Edition):

Dumas, John Paul, 1991-. “Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems.” 2019. Doctoral Dissertation, Rutgers University. Accessed February 16, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/61734/.

MLA Handbook (7^th Edition):

Dumas, John Paul, 1991-. “Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems.” 2019. Web. 16 Feb 2020.

Vancouver:

Dumas, John Paul 1. Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2020 Feb 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61734/.

Council of Science Editors:

Dumas, John Paul 1. Compressive endoscopy - a computational imaging approach for fiber-bundle-based imaging systems. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/61734/

University of Aberdeen

4. Egbe, Nneoyi Onen. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.

Degree: 2008, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25469 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499089

► In computed radiography (CR) images, dose reduction up to 0.10 mGy is possible in chest radiography without image manipulation. A lower dose of 0.06 mGy… (more)

Subjects/Keywords: 615.84; Diagnostic Imaging

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APA (6^th Edition):

Egbe, N. O. (2008). Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25469 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499089

Chicago Manual of Style (16^th Edition):

Egbe, Nneoyi Onen. “Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.” 2008. Doctoral Dissertation, University of Aberdeen. Accessed February 16, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25469 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499089.

MLA Handbook (7^th Edition):

Egbe, Nneoyi Onen. “Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.” 2008. Web. 16 Feb 2020.

Vancouver:

Egbe NO. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. [Internet] [Doctoral dissertation]. University of Aberdeen; 2008. [cited 2020 Feb 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25469 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499089.

Council of Science Editors:

Egbe NO. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. [Doctoral Dissertation]. University of Aberdeen; 2008. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25469 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499089

Columbia University

5. Monard, Francois. Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.

Degree: 2012, Columbia University

URL: https://doi.org/10.7916/D8DZ0GDK

► This thesis explores two mathematical routes that make the transition from some severely ill-posed parameter reconstruction problems to better-posed versions of them. The general introduction… (more)

▼ This thesis explores two mathematical routes that make the transition from some severely ill-posed parameter reconstruction problems to better-posed versions of them. The general introduction starts by defining what we mean by an inverse problem and its theoretical analysis. We then provide motivations that come from the field of medical imaging. The first part consists in the analysis of an inverse problem involving the Boltzmann transport equation, with applications in Optical Tomography. There we investigate the reconstruction of the spatially-dependent part of the scattering kernel, from knowledge of angularly averaged outgoing traces of transport solutions and isotropic boundary sources. We study this problem in the stationary regime first, then in the time-harmonic regime. In particular we show, using techniques from functional analysis and stationary phase, that this inverse problem is severely ill-posed in the former setting, whereas it is mildly ill-posed in the latter. In this case, we deduce that making the measurements depend on modulation frequency allows to improve the stability of reconstructions. In the second part, we investigate the inverse problem of reconstructing a tensor-valued conductivity (or diffusion) coefficient in a second-order elliptic partial differential equation, from knowledge of internal measurements of power density type. This problem finds applications in the medical imaging modalities of Electrical Impedance Tomography and Optical Tomography, and the fact that one considers power densities is justified in practice by assuming a coupling of this physical model with ultrasound waves, a coupling assumption that is characteristic of so-called hybrid medical imaging methods. Starting from the famous Calderon's problem (i.e. the same parameter reconstruction problem from knowledge of boundary fluxes of solutions), and recalling its lack of injectivity and severe instability, we show how going from Dirichlet-to-Neumann data to considering the power density operator leads to reconstruction of the full conductivity tensor via explicit inversion formulas. Moreover, such reconstruction algorithms only require the loss of either zero or one derivative from the power density functionals to the unknown, depending on what part of the tensor one wants to reconstruct. The inversion formulas are worked out with the help of linear algebra and differential geometry, in particular calculus with the Euclidean connection. The practical pay-off of such theoretical improvements in injectivity and stability is twofold: (i) the lack of injectivity of Calderà³n's problem, no longer existing when using power density measurements, implies that future medical imaging modalities such as hybrid methods may make anisotropic properties of human tissues more accessible; (ii) the improvements in stability for both problems in transport and conductivity may yield practical improvements in the resolution of images of the reconstructed coefficients.

Subjects/Keywords: Mathematics; Diagnostic imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Monard, F. (2012). Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8DZ0GDK

Chicago Manual of Style (16^th Edition):

Monard, Francois. “Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.” 2012. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8DZ0GDK.

MLA Handbook (7^th Edition):

Monard, Francois. “Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.” 2012. Web. 16 Feb 2020.

Vancouver:

Monard F. Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8DZ0GDK.

Council of Science Editors:

Monard F. Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D8DZ0GDK

University of Nottingham

6. Six, Joseph. New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment.

Degree: PhD, 2014, University of Nottingham

URL: http://eprints.nottingham.ac.uk/14118/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632454

► Hyperpolarized 83Kr has previously demonstrated MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. One-dimensional nuclear magnetic… (more)

Subjects/Keywords: 616.07; WN Radiology. Diagnostic imaging

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APA (6^th Edition):

Six, J. (2014). New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/14118/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632454

Chicago Manual of Style (16^th Edition):

Six, Joseph. “New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment.” 2014. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/14118/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632454.

MLA Handbook (7^th Edition):

Six, Joseph. “New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment.” 2014. Web. 16 Feb 2020.

Vancouver:

Six J. New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment. [Internet] [Doctoral dissertation]. University of Nottingham; 2014. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/14118/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632454.

Council of Science Editors:

Six J. New MRI contrast agents through spin exchange optical pumping of noble gases with a nuclear electric quadrupole moment. [Doctoral Dissertation]. University of Nottingham; 2014. Available from: http://eprints.nottingham.ac.uk/14118/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632454

University of Nottingham

7. Manita, Muftah. The prognostic value of perfusion MRI in cerebral glioma.

Degree: Thesis (M.D.), 2012, University of Nottingham

URL: http://eprints.nottingham.ac.uk/12776/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570359

► Introduction Cerebral glioma is the most prevalent primary brain tumour, of which the majority are high grade gliomas. High grade gliomas possess a poor prognosis,… (more)

▼ Introduction Cerebral glioma is the most prevalent primary brain tumour, of which the majority are high grade gliomas. High grade gliomas possess a poor prognosis, and glioblastoma patients survive less than one year after diagnosis. To date, histological grading is used as the standard technique for diagnosis and survival prediction. Previous studies using advanced techniques such as MR Perfusion have achieved a high sensitivity but a low specificity in identifying high grade gliomas. Moreover, they have failed to distinguish glioblastoma from anaplastic glioma. The purpose of the study presented here is to assess the diagnostic and prognostic value for cerebral glioma of cerebral blood volume maps derived from MR perfusion. Methods This retrospective study was approved by the local research ethics committee and clinical audit office. This study included 123 patients with newly diagnosed cerebral glioma, of all grades. Histological diagnosis was used as the standard reference for all potential patients. The relative tumour blood volume (rTBVmax) derived from MR perfusion was used for radiological grading of cerebral glioma. Receiver operating characteristics (ROC) were used to define the best threshold value in distinguishing the glioma grades and in determining the accuracy values (sensitivity, specificity, and positive and negative predictive values). For survival analysis, Kaplan-Meier was used to illustrate and compare the discriminatory value of the histological and radiological classifications. A multiple Cox regression model was used to assess the prognostic value of both classifications in addition to other tested demographic and clinical variables. Finally, the influence of potential moderators was assessed using ANOVA, to assess whether the variation in rTBVmax was only due to the difference in tumour grades. Results A model data set (n = 50) produced a 7-fold increase of TBVmax in tumour versus white matter and provided sensitivity and specificity of 97% and 94%, respectively, in distinguishing high versus low grade glioma. Moreover, a threshold value of 9.6 provided sensitivity and specificity of 100% and 56% in differentiating glioblastoma within the group of high grade gliomas. These threshold values were applied to the second group (n = 73) and provided sensitivity and specificity of 96% and 95% in distinguishing high versus low grade glioma, and 97% and 73% in differentiating, within the high grade gliomas, glioblastoma from anaplastic glioma. Using these two thresholds for a three-tier radiological classification, both the Kaplan-Meier plots and the multiple Cox regression showed that radiological classification was the most independent predictor of survival and tumour progression. The proposed radiological classification system was better than histological classification in predicting glioma patients survival especially noted in a group of moderately hyperaemic rTBVmax. Conclusion MR perfusion is a non-invasive and robust technique in glioma grading and survival prediction. The diagnostic value of…

Subjects/Keywords: 616.99; WN Radiology. Diagnostic imaging

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APA (6^th Edition):

Manita, M. (2012). The prognostic value of perfusion MRI in cerebral glioma. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/12776/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570359

Chicago Manual of Style (16^th Edition):

Manita, Muftah. “The prognostic value of perfusion MRI in cerebral glioma.” 2012. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/12776/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570359.

MLA Handbook (7^th Edition):

Manita, Muftah. “The prognostic value of perfusion MRI in cerebral glioma.” 2012. Web. 16 Feb 2020.

Vancouver:

Manita M. The prognostic value of perfusion MRI in cerebral glioma. [Internet] [Doctoral dissertation]. University of Nottingham; 2012. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/12776/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570359.

Council of Science Editors:

Manita M. The prognostic value of perfusion MRI in cerebral glioma. [Doctoral Dissertation]. University of Nottingham; 2012. Available from: http://eprints.nottingham.ac.uk/12776/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570359

University of Nairobi

8. Auka, Joash. Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) .

Degree: 2003, University of Nairobi

URL: http://hdl.handle.net/11295/6224

► A three-month descriptive cross-sectional survey about the care of 400 patients referred for radiological investigations at KNH X -ray department and the findings are presented.… (more)

▼ A three-month descriptive cross-sectional survey about the care of 400 patients referred for radiological investigations at KNH X -ray department and the findings are presented. The specific purpose of this survey was to determine the present level of patient care in both content and provision in the x-ray department of KNH and make recommendations for the development of the imaging services. To obtain the necessary information for this research, patients were required to complete a questionnaire comprising of general aspects of care. The technical aspects of care were evaluated by use of another questionnaire. Employees of KNH and all the on-call patients were excluded from the study. All the radiological examination rooms were covered during this survey. The questionnaires used had both open and closed questions. The data from closed questions allowed for numerical analysis. A total of233 females and 167 males were surveyed. The age range was from a 2-day old neonate to adults above 70 years with a median age of 26 years. The majority (50%) of patients were referred from the KNH clinics. Out of388 patients that responded, 47.95% came unaccompanied to the X-ray department. For 75.5% of the participants, the sign posting within the X-ray department was easy to follow. The majority (84.4%) of the patients were made to wait for more than 10 minutes at the reception desk. The staff at the reception was found to be considerate and kind by 63.2% of the respondents. The waiting area was overcrowded and boring to 62.8% of the participants. It was also the area that was most criticized in the study. The level of cleanliness was judged acceptable. The changing gowns were oversize for 44.4% of the 81 respondents. 93.50/0 of the patients were booked. 900/0 of those that were given instructions for the radiological examination found the explanation easy to follow. The KNH charges for radiological examinations in comparison with other hospitals in Nairobi were reasonable. The majority of the comments from the open-ended questions were compliments for staff. The practice of technical aspects of care at the KNH X-ray department by radiographers and radiologists was impressive. In conclusion, many of the responses from this study, especially from the openended questions, were very reasonable and valuable as the basis for any improvements in the x-ray department. The majority of measures required by patients could be best facilitated by the formation of a department customer relation's workshop. The group should comprise a number of staff that is committed to a more patient-oriented service. The first task for this group is to form an action plan for the patient Waiting area, as it was the area most criticized in the study. Further to this, there is need for regular continuing medical education programs for both radiographers and radiologists to enhance their practice to even greater heights of excellence.

Subjects/Keywords: Diagnostic imaging

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APA (6^th Edition):

Auka, J. (2003). Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) . (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/6224

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Auka, Joash. “Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) .” 2003. Thesis, University of Nairobi. Accessed February 16, 2020. http://hdl.handle.net/11295/6224.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Auka, Joash. “Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) .” 2003. Web. 16 Feb 2020.

Vancouver:

Auka J. Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) . [Internet] [Thesis]. University of Nairobi; 2003. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/11295/6224.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Auka J. Patient care in the diagnostic imaging department of kenyatta National Hospital (K.N.H.) . [Thesis]. University of Nairobi; 2003. Available from: http://hdl.handle.net/11295/6224

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Nottingham

9. Habib, Josef. Development & optimization of diffusion tensor imaging at high field strengths in translational research.

Degree: 2012, University of Nottingham

URL: http://eprints.nottingham.ac.uk/12405/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559560

► Ever since the inception of Diffusion Tensor Imaging (DTI), unabated advancements in its capabilities and applications have been spearheaded by a vibrant research effort to… (more)

▼ Ever since the inception of Diffusion Tensor Imaging (DTI), unabated advancements in its capabilities and applications have been spearheaded by a vibrant research effort to devise dedicated acquisition sequences, protocols and hardware. In translational research, however, the transition of these innovations into the arenas of biomedical research, and ultimately clinical practice is frequently hampered by practical considerations. These include the availability of appropriate expertise, time and resources for their implementation, and considerations of compatibility with established techniques and results reported in literature. Such concerns provide the impetus to maximize the utility of existing protocols before attempting the development of novel dedicated techniques. In this thesis, three investigations, each targeting a different DTI application, are presented. The strategy implemented throughout involves assessing the suitability of existing sequences for the intended task, and determining any limiting factors, evaluating whether appropriate modifications of the acquisition protocols used are capable of alleviating limitations, and developing novel, dedicated protocols wherever necessary. The value and, importantly, the wide scope of this approach in answering important research questions is exemplified through the breadth of the studies presented. The first study presents, for the first time, a quantitative evaluation of the effects of cardiac pulsation on prevalent DTI metrics acquired with a specific acquisition protocol used routinely in clinical practice. Findings inform the on-going debate on whether the investment in cardiac gating is merited by improvements in data quality. Effects were observed during only 6 % of the cardiac cycle, and not 20 % as previously reported. The impact of cardiac pulsation on selected diffusion Tensor indices was minimal in group studies, but of potential practical relevance in individual cases. Methods to predict which individuals may benefit from gating have also been suggested. Secondly, the feasibility of post-mortem DTI was established through the successful acquisition, also for the first time, of DTI data on a chemically fixed whole human post-mortem brain using a clinical sequence. Previous failed attempts have been attributed to insufficient SNR. In this study scanner stability and distortion are found to be the main limiting factors, and mitigated using appropriate averaging and co-registration strategies. The third study assessed the potential of ultra-high field strength DTI by identifying and optimizing the potential strengths of DTI at 7T. Subsequent to optimization with respect to SNR, the main sources of artefact were found to be B1 inhomogeneity and inadequate fat suppression. Both were alleviated by modification of the available acquisition protocol, resulting in higher SNR and data quality than previously reported. Finally, in developing appropriate data quality measures, the ‘Difference method’, commonly used for the quantification of SNR, was found to be…

Subjects/Keywords: 616.07548; WN Radiology. Diagnostic imaging

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APA (6^th Edition):

Habib, J. (2012). Development & optimization of diffusion tensor imaging at high field strengths in translational research. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/12405/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559560

Chicago Manual of Style (16^th Edition):

Habib, Josef. “Development & optimization of diffusion tensor imaging at high field strengths in translational research.” 2012. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/12405/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559560.

MLA Handbook (7^th Edition):

Habib, Josef. “Development & optimization of diffusion tensor imaging at high field strengths in translational research.” 2012. Web. 16 Feb 2020.

Vancouver:

Habib J. Development & optimization of diffusion tensor imaging at high field strengths in translational research. [Internet] [Doctoral dissertation]. University of Nottingham; 2012. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/12405/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559560.

Council of Science Editors:

Habib J. Development & optimization of diffusion tensor imaging at high field strengths in translational research. [Doctoral Dissertation]. University of Nottingham; 2012. Available from: http://eprints.nottingham.ac.uk/12405/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559560

University of Nottingham

10. Hughes-Riley, Theodore. Development and application of hyperpolarized krypton-83 as a new MRI contrast agent.

Degree: PhD, 2014, University of Nottingham

URL: http://eprints.nottingham.ac.uk/14460/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664675

► Hyperpolarized (hp) gases such 129Xe and 83Kr (spin I = 1/2 and I = 9/2 respectively) can allow for significantly enhanced signal in a number… (more)

Subjects/Keywords: 616.07; WN Radiology. Diagnostic imaging

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APA (6^th Edition):

Hughes-Riley, T. (2014). Development and application of hyperpolarized krypton-83 as a new MRI contrast agent. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/14460/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664675

Chicago Manual of Style (16^th Edition):

Hughes-Riley, Theodore. “Development and application of hyperpolarized krypton-83 as a new MRI contrast agent.” 2014. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/14460/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664675.

MLA Handbook (7^th Edition):

Hughes-Riley, Theodore. “Development and application of hyperpolarized krypton-83 as a new MRI contrast agent.” 2014. Web. 16 Feb 2020.

Vancouver:

Hughes-Riley T. Development and application of hyperpolarized krypton-83 as a new MRI contrast agent. [Internet] [Doctoral dissertation]. University of Nottingham; 2014. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/14460/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664675.

Council of Science Editors:

Hughes-Riley T. Development and application of hyperpolarized krypton-83 as a new MRI contrast agent. [Doctoral Dissertation]. University of Nottingham; 2014. Available from: http://eprints.nottingham.ac.uk/14460/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664675

Ryerson University

11. Jenkins, Catherine Anne May. Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context.

Degree: 2016, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A5059

► Drawing on existing theoretical work, as well as field research, this dissertation examines the impact of medical imaging technologies on communication between physicians and older… (more)

▼ Drawing on existing theoretical work, as well as field research, this dissertation examines the impact of medical imaging technologies on communication between physicians and older patients when diagnostics often privilege disembodied data over the patient voice. Current diagnostic trends are contextualized within the history of medicine, from Ancient Greece to the present, including the development of imaging. Since the 1970s, advanced medical imaging technologies (e.g., ultrasound, computed tomography, magnetic resonance imaging) have become the diagnostic norm in Western medicine. The rapidity of this shift, which renders the human body as flattened data, can outstrip considerations of the implications of applying such technologies to living patients. Focusing on older patients, who may be less technologically savvy than younger patients or medical professionals, the field research begins with semi-structured interviews of patients over age sixty-five, exploring their encounters with medical imaging equipment and professionals. This data is interrogated qualitatively using Foucauldian discourse analysis drawing on Andrea Doucet’s model of slow scholarship, and informed by Arthur Frank’s notion of letting stories breathe; themes were allowed to surface from the patients’ narratives, rather than imposed by the researcher. Information emerging from the data considers patients’ emotions, unexpected physical sensations, communicative strategies and rationalizations, as well as Foucauldian allusions to power. Observational research was also conducted during encounters between physicians and simulated patients in the presence of medical images; these encounters were followed by reflective exit interviews. Research indicates that although physicians are increasingly trained in patient-centred communication, it is not always optimally practised. Physicians are sometimes more comfortable with the medical discourse of disease than with the emotional, metaphoric language of the patient’s illness experience. Since the development of modern Western medicine in Europe of the late 1700s, physicians have been trained to seek pathology, with the increasing aid of medical technologies, rather than listening to their patients. For older patients, who may experience multiple co-morbidities, the lack of communication around advanced medical technologies can increase their sense of vulnerability and anxiety. The dissertation concludes with recommendations for both patients and practitioners to improve communication in the medical context.

Subjects/Keywords: Physician and patient; Diagnostic imaging

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APA (6^th Edition):

Jenkins, C. A. M. (2016). Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A5059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jenkins, Catherine Anne May. “Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context.” 2016. Thesis, Ryerson University. Accessed February 16, 2020. https://digital.library.ryerson.ca/islandora/object/RULA%3A5059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jenkins, Catherine Anne May. “Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context.” 2016. Web. 16 Feb 2020.

Vancouver:

Jenkins CAM. Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context. [Internet] [Thesis]. Ryerson University; 2016. [cited 2020 Feb 16]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jenkins CAM. Older patient-physician communication: an examination of the tensions of the patient-centred model within a biotechnological context. [Thesis]. Ryerson University; 2016. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ryerson University

12. Jakubovic, Raphael, Y. MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases.

Degree: 2014, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3089

► We sought to determine the utility of early relative blood volume (rCBV), relative blood flow (rCBF) and permeability (K2 trans) measurements as biomarkers of radiation… (more)

Subjects/Keywords: Diagnostic imaging; Cancer – Pathophysiology

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APA (6^th Edition):

Jakubovic, Raphael, Y. (2014). MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jakubovic, Raphael, Y. “MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases.” 2014. Thesis, Ryerson University. Accessed February 16, 2020. https://digital.library.ryerson.ca/islandora/object/RULA%3A3089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jakubovic, Raphael, Y. “MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases.” 2014. Web. 16 Feb 2020.

Vancouver:

Jakubovic, Raphael Y. MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases. [Internet] [Thesis]. Ryerson University; 2014. [cited 2020 Feb 16]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jakubovic, Raphael Y. MRI based physiological parameters are biomarkers of tumor and non tumor tissue response following radiation to brain metastases. [Thesis]. Ryerson University; 2014. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

13. Lyle, David Kenneth. IRE : an image registration environment for volumetric medical images.

Degree: College of Engineering, 2001, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/8142

Subjects/Keywords: Diagnostic imaging.

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APA (6^th Edition):

Lyle, D. K. (2001). IRE : an image registration environment for volumetric medical images. (Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/8142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lyle, David Kenneth. “IRE : an image registration environment for volumetric medical images.” 2001. Thesis, Montana State University. Accessed February 16, 2020. https://scholarworks.montana.edu/xmlui/handle/1/8142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lyle, David Kenneth. “IRE : an image registration environment for volumetric medical images.” 2001. Web. 16 Feb 2020.

Vancouver:

Lyle DK. IRE : an image registration environment for volumetric medical images. [Internet] [Thesis]. Montana State University; 2001. [cited 2020 Feb 16]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/8142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lyle DK. IRE : an image registration environment for volumetric medical images. [Thesis]. Montana State University; 2001. Available from: https://scholarworks.montana.edu/xmlui/handle/1/8142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Ng, Aik Hao. Hybrid gamma camera imaging : translation from bench to bedside.

Degree: PhD, 2018, University of Nottingham

URL: http://eprints.nottingham.ac.uk/49335/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748274

► There is increasing interest in the use of small field of view (SFOV) portable gamma cameras in medical imaging. A novel hybrid optical-gamma camera (HGC)… (more)

▼ There is increasing interest in the use of small field of view (SFOV) portable gamma cameras in medical imaging. A novel hybrid optical-gamma camera (HGC) has been developed through a collaboration between the Universities of Leicester and Nottingham. This system offers high resolution gamma and optical imaging and shows potential for use at the patient bedside, or in the operating theatre. The aim of this thesis was to translate the HGC technology from in vitro laboratory studies to clinical use in human subjects. Pilot studies were undertaken with the HGC as part of this thesis. Furthermore, efforts have been made to transform the HGC technologies into a new medical device, known as Nebuleye. Initial physical evaluation of the pre-production prototype camera was carried out as part of the device developmental process, highlighting some aspects of the design that require further modification. A complete and rigorous testing scheme to assess the pre-production prototype camera has been developed and successfully implemented. The newly introduced tests enabled the system uniformity, system sensitivity, detector head shielding leakage, optical-gamma image alignment and optical image quality of the hybrid camera to be assessed objectively. This harmonised testing scheme allows characterisation and direct comparison of SFOV gamma cameras. In vitro and in vivo preclinical imaging was undertaken to examine the performance of the SFOV gamma cameras for experimental animal studies. The results of animal study have shown for the first time the feasibility and performance of these SFOV gamma cameras for imaging mice injected with a newly developed 111In labelled hybrid tracer. Further investigations are needed to improve the system resolution and prepare the camera system for combined gamma-near infrared fluorescence imaging in future. A systematic in vitro laboratory assessment method has been established to examine the imaging performance of the SFOV gamma camera in radioguided sentinel lymph node biopsy (SLNB) and radioactive seed localisation procedures for breast cancer surgery. Further preparatory work was undertaken to carry out a pilot clinical trial of the use of the pre-production prototype camera in sentinel node localisation procedures during breast cancer surgery. The clinical study protocol and routine quality control procedures have been established and are suitable for future use. Baseline data on the camera performance assessed using the routine quality control scheme have been obtained. Finally, the capabilities of the SFOV gamma camera were assessed. This has provided baseline data on user feedback and the imaging consequences on operator motion effects, as well as examining the detectability of a range of radionuclides, including 99mTc, 111In, 123I, 125I and 75Se. The first clinical results of the use of the HGC in clinical hybrid optical-gamma imaging in patients administered with 99mTc and 123I labelled radiopharmaceuticals have been reported. This clinical study has demonstrated the feasibility and…

Subjects/Keywords: WN Radiology. Diagnostic imaging

14 more images…

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APA (6^th Edition):

Ng, A. H. (2018). Hybrid gamma camera imaging : translation from bench to bedside. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/49335/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748274

Chicago Manual of Style (16^th Edition):

Ng, Aik Hao. “Hybrid gamma camera imaging : translation from bench to bedside.” 2018. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/49335/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748274.

MLA Handbook (7^th Edition):

Ng, Aik Hao. “Hybrid gamma camera imaging : translation from bench to bedside.” 2018. Web. 16 Feb 2020.

Vancouver:

Ng AH. Hybrid gamma camera imaging : translation from bench to bedside. [Internet] [Doctoral dissertation]. University of Nottingham; 2018. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/49335/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748274.

Council of Science Editors:

Ng AH. Hybrid gamma camera imaging : translation from bench to bedside. [Doctoral Dissertation]. University of Nottingham; 2018. Available from: http://eprints.nottingham.ac.uk/49335/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748274

Virginia Tech

15. Menciotti, Giulio. Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease.

Degree: PhD, Veterinary Medicine, 2017, Virginia Tech

URL: http://hdl.handle.net/10919/77704

► Myxomatous mitral valve degeneration (MMVD) is the most common canine cardiac disease. In the studies presented in this dissertation, we used advanced echocardiographic techniques to… (more)

▼ Myxomatous mitral valve degeneration (MMVD) is the most common canine cardiac disease. In the studies presented in this dissertation, we used advanced echocardiographic techniques to elucidate several aspects of MMVD in dogs. Our hypothesis was that the mitral valve (MV) morphology could have a role in the development of MMVD. First, we tested whether we could use real time three-dimensional transthoracic echocardiography (RT-3DTTE), and an offline software for MV analysis to evaluate canine MV. We described that the technique was feasible and repeatable, we evaluated the morphology of the MV in healthy dogs, and we provided reference values for MV morphologic variables in this species. Then, we used the same technique to compare healthy dogs to dogs affected by MMVD. We found that dogs affected by MMVD have more circular and flatter valve. We then analyzed the MV of healthy Cavalier King Charles Spaniels (CKCSs), given the high predisposition of this breed for MMVD. Our findings indicate that compared to healthy dogs of other breeds, the MV of healthy CKCSs is flatter and has less leaflet tenting, corroborating our hypothesis that an altered MV morphology could represent a predisposing factor for disease development. We also used RT–3DTTE to characterize the area of the regurgitant MV orifice of dogs affected with MMVD, finding that the technique requires further standardization in order to become clinically useful. The elevation of pulmonary venous pressure caused by MMVD can, in some dogs, cause pulmonary arterial hypertension (PH), which is a risk factor associated with worse outcome in dogs with MMVD. Diagnosis of PH in dogs with MMVD is usually made by estimating pulmonary pressure using Doppler echocardiography. We are currently evaluating the accuracy of this technique, compared to invasive measurement of pulmonary pressure. Only preliminary data are presented regarding this study, as the disclosure of the blinding would have infringed the power of the study. Our preliminary results demonstrate that there is only moderate agreement between the two techniques, indicating that caution should be used when deriving the non-invasive estimation of systolic pulmonary pressure in order to make clinical decisions. Advisors/Committee Members: Borgarelli, Michele (committeechair), Huckle, William Rupert (committee member), Abbott, Jonathan A. (committee member), Guglielmini, Carlo (committee member), Haggstrom, Jens Ulrik (committee member), De Vita, Raffaella (committee member).

Subjects/Keywords: canine; heart; diagnostic; imaging

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APA (6^th Edition):

Menciotti, G. (2017). Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77704

Chicago Manual of Style (16^th Edition):

Menciotti, Giulio. “Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease.” 2017. Doctoral Dissertation, Virginia Tech. Accessed February 16, 2020. http://hdl.handle.net/10919/77704.

MLA Handbook (7^th Edition):

Menciotti, Giulio. “Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease.” 2017. Web. 16 Feb 2020.

Vancouver:

Menciotti G. Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/10919/77704.

Council of Science Editors:

Menciotti G. Advanced Echocardiographic Imaging In Dogs With Myxomatous Mitral Valve Disease. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/77704

University of Aberdeen

16. Egbe, Nneoyi Onen. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.

Degree: School of Medical Sciences., 2008, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=25469&custom_att_2=simple_viewer

Subjects/Keywords: Diagnostic Imaging

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APA (6^th Edition):

Egbe, N. O. (2008). Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=25469&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Egbe, Nneoyi Onen. “Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.” 2008. Doctoral Dissertation, University of Aberdeen. Accessed February 16, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=25469&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Egbe, Nneoyi Onen. “Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality.” 2008. Web. 16 Feb 2020.

Vancouver:

Egbe NO. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. [Internet] [Doctoral dissertation]. University of Aberdeen; 2008. [cited 2020 Feb 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=25469&custom_att_2=simple_viewer.

Council of Science Editors:

Egbe NO. Measurement of dose in diagnostic radiology and the effect of dose reduction on image quality. [Doctoral Dissertation]. University of Aberdeen; 2008. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25469 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=25469&custom_att_2=simple_viewer

University of Arizona

17. MYERS, KYLE JEAN. VISUAL PERCEPTION IN CORRELATED NOISE (MODELS).

Degree: 1985, University of Arizona

URL: http://hdl.handle.net/10150/188006

► This dissertation concerns the ability of human observers to perform detection tasks in medical images that contain structured noise. We shall show that physical measures… (more)

▼ This dissertation concerns the ability of human observers to perform detection tasks in medical images that contain structured noise. We shall show that physical measures of image quality, such as signal-to-noise ratio (SNR), resolution, modulation transfer function (MTF), and contrast, do not accurately predict how well an observer can detect lesions in an image. We have found that for images with equal pixel SNR, humans can detect a low contrast object more readily in images that have a low-pass noise structure, as opposed to a high-pass noise structure. This finding is important in the comparison of images generated by a classical pinhole imaging system with images generated by a computed tomography imager. We would like to have a figure of merit that accurately predicts a physician's ability to perform perceptual tasks. That is, we want a figure of merit for imaging systems that is more than an evaluation of the physician's performance, measured using human observers and an accepted method such as receiver operating characteristic (ROC) techniques. We want a figure of merit that we can calculate without requiring lengthy observer studies. To perform this calculation, we need a model of the imaging system hardware in cascade with a verified model of the human observer. We have chosen to approach this problem by modelling the human observer as an ideal observer. Our hypothesis is that the human observer acts approximately as an ideal-observer who does not have the ability to prewhiten the noise in an image. Without this ability, the ideal observer's detection performance for even a simple task is degraded substantially in correlated noise. This is just the effect that we have found for human observers. In search of a physiological explanation for a human observer's inability to do prewhitening, we shall investigate the detection capability of the ideal observer when a frequency-selective mechanism is invoked. This mechanism corresponds to the frequency channels known to exist in the human visual system. We shall show that the presence of such a mechanism can explain the degradation of human observer performance in correlated noise. Advisors/Committee Members: Barrett, D. H (advisor).

Subjects/Keywords: Diagnostic imaging.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MYERS, K. J. (1985). VISUAL PERCEPTION IN CORRELATED NOISE (MODELS). (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/188006

Chicago Manual of Style (16^th Edition):

MYERS, KYLE JEAN. “VISUAL PERCEPTION IN CORRELATED NOISE (MODELS). ” 1985. Doctoral Dissertation, University of Arizona. Accessed February 16, 2020. http://hdl.handle.net/10150/188006.

MLA Handbook (7^th Edition):

MYERS, KYLE JEAN. “VISUAL PERCEPTION IN CORRELATED NOISE (MODELS). ” 1985. Web. 16 Feb 2020.

Vancouver:

MYERS KJ. VISUAL PERCEPTION IN CORRELATED NOISE (MODELS). [Internet] [Doctoral dissertation]. University of Arizona; 1985. [cited 2020 Feb 16]. Available from: http://hdl.handle.net/10150/188006.

Council of Science Editors:

MYERS KJ. VISUAL PERCEPTION IN CORRELATED NOISE (MODELS). [Doctoral Dissertation]. University of Arizona; 1985. Available from: http://hdl.handle.net/10150/188006

Columbia University

18. Prins, Robert Dean. Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans.

Degree: 2011, Columbia University

URL: https://doi.org/10.7916/D86M3CMV

► Diagnosing the severity of blunt trauma injuries is difficult and involves the use of diagnostic radiological scanning. The primary diagnostic radiology modality used for assessing… (more)

▼ Diagnosing the severity of blunt trauma injuries is difficult and involves the use of diagnostic radiological scanning. The primary diagnostic radiology modality used for assessing these injuries is computed tomography (CT). CT delivers more radiation dose than other diagnostic scanning modalities. Trauma patients are at an increased risk of radiation induced cancer because of the cumulative dose effects from multiple scanning procedures. Current methods for estimating effective dose, the quantity used to describe the whole body health detriment from radiation, involves the use of published conversion coefficients and procedure specific machine parameters such as dose-length-product based on computed tomography dose index and scan length. Other methods include the use of Monte Carlo simulations based upon the specific machine geometry and radiation source. Unless the requisite machine information is known, the only means of estimating the effective dose is through the use of generic estimates that are published by scientific radiation committees and have a wide range of values. This research addressed a knowledge gap in assigning effective doses from computed tomography when machine parameters knowledge is either unknown or incomplete. The research involved the development of a new method of estimating the effective dose from CT through the use of regression models incorporating the use of patient parameters as opposed to machine specific parameters. This new method was experimentally verified using two adult anthropomorphic phantoms and optically stimulated luminescent dosimeters. The new method was then compared against a real patient population undergoing similar computed tomography scanning procedures. Utilizing statistical procedures, the new method was tested for repeatability and bias against the current conversion coefficient method. The analysis of the new method verifies that the estimation ability is similar to recent research indicating that the older conversion coefficient methods can underestimate the effective dose to the patient by up to 40%. The new method can be used as a retrospective tool for effective dose estimation from CT trauma protocols for a patient population with physical characteristics similar to the U.S. Army Soldier population.

Subjects/Keywords: Medical sciences; Diagnostic imaging

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APA (6^th Edition):

Prins, R. D. (2011). Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D86M3CMV

Chicago Manual of Style (16^th Edition):

Prins, Robert Dean. “Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans.” 2011. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D86M3CMV.

MLA Handbook (7^th Edition):

Prins, Robert Dean. “Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans.” 2011. Web. 16 Feb 2020.

Vancouver:

Prins RD. Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans. [Internet] [Doctoral dissertation]. Columbia University; 2011. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D86M3CMV.

Council of Science Editors:

Prins RD. Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans. [Doctoral Dissertation]. Columbia University; 2011. Available from: https://doi.org/10.7916/D86M3CMV

Columbia University

19. Burgess, Sean Adam. Development and Applications of Laminar Optical Tomography for In Vivo Imaging.

Degree: 2011, Columbia University

URL: https://doi.org/10.7916/D8XW4RRV

► Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved measurements of absorption and fluorescence contrast in scattering tissue. LOT was first… (more)

▼ Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved measurements of absorption and fluorescence contrast in scattering tissue. LOT was first demonstrated in 2004 by Hillman et al [1]. The technique combines a non-contact laser scanning geometry, similar to a low magnification confocal microscope, with the imaging principles of diffuse optical tomography (DOT). This thesis describes the development and application of a second generation LOT system, which acquires both fluorescence and multi-wavelength measurements simultaneously and is better suited for in vivo measurements. Chapter 1 begins by reviewing the interactions of light with tissue that form the foundation of optical imaging. A range of related optical imaging techniques and the basic principles of LOT imaging are then described. In Chapter 2, the development of the new LOT imaging system is described including the implementation of a series of interfaces to allow clinical imaging. System performance is then evaluated on a range of imaging phantoms. Chapter 3 describes two in vivo imaging applications explored using the second generation LOT system, first in a clinical setting where skin lesions were imaged, and then in a laboratory setting where LOT imaging was performed on exposed rat cortex. The final chapter provides a brief summary and describes future directions for LOT. LOT has the potential to find applications in medical diagnostics, surgical guidance, and in-situ monitoring owing to its sensitivity to absorption and fluorescence contrast as well as its ability to provide depth sensitive measures. Optical techniques can characterize blood volume and oxygenation, two important biological parameters, through measurements at different wavelengths. Fluorescence measurements, either from autofluorescence or fluorescent dyes, have shown promise for identifying and analyzing lesions in various epithelial tissues including skin [2, 3], colon [4], esophagus [5, 6], oral mucosa [7, 8], and cervix [9]. The desire to capture these types of measurements with LOT motivated much of the work presented here.

Subjects/Keywords: Biomedical engineering; Diagnostic imaging

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APA (6^th Edition):

Burgess, S. A. (2011). Development and Applications of Laminar Optical Tomography for In Vivo Imaging. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8XW4RRV

Chicago Manual of Style (16^th Edition):

Burgess, Sean Adam. “Development and Applications of Laminar Optical Tomography for In Vivo Imaging.” 2011. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8XW4RRV.

MLA Handbook (7^th Edition):

Burgess, Sean Adam. “Development and Applications of Laminar Optical Tomography for In Vivo Imaging.” 2011. Web. 16 Feb 2020.

Vancouver:

Burgess SA. Development and Applications of Laminar Optical Tomography for In Vivo Imaging. [Internet] [Doctoral dissertation]. Columbia University; 2011. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8XW4RRV.

Council of Science Editors:

Burgess SA. Development and Applications of Laminar Optical Tomography for In Vivo Imaging. [Doctoral Dissertation]. Columbia University; 2011. Available from: https://doi.org/10.7916/D8XW4RRV

Columbia University

20. Taei-Tehrani, Mohammad Reza. Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times.

Degree: 2012, Columbia University

URL: https://doi.org/10.7916/D88S4WWC

► The Pseudo Random Arterial Modulation (PRAM) is a non-invasive MRI based method to measure blood flow. It does not require any contrast agent but rather… (more)

Subjects/Keywords: Biomedical engineering; Diagnostic imaging; Psychometrics

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APA (6^th Edition):

Taei-Tehrani, M. R. (2012). Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D88S4WWC

Chicago Manual of Style (16^th Edition):

Taei-Tehrani, Mohammad Reza. “Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times.” 2012. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D88S4WWC.

MLA Handbook (7^th Edition):

Taei-Tehrani, Mohammad Reza. “Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times.” 2012. Web. 16 Feb 2020.

Vancouver:

Taei-Tehrani MR. Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D88S4WWC.

Council of Science Editors:

Taei-Tehrani MR. Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D88S4WWC

Columbia University

21. Van Snellenberg, Jared Xavier. An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia.

Degree: 2012, Columbia University

URL: https://doi.org/10.7916/D8TH8TSX

► Individuals with schizophrenia exhibit substantial deficits in their ability to perform working memory (WM) tasks, and these deficits have a critical impact on health and… (more)

Subjects/Keywords: Psychology; Neurosciences; Diagnostic imaging

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APA (6^th Edition):

Van Snellenberg, J. X. (2012). An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8TH8TSX

Chicago Manual of Style (16^th Edition):

Van Snellenberg, Jared Xavier. “An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia.” 2012. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8TH8TSX.

MLA Handbook (7^th Edition):

Van Snellenberg, Jared Xavier. “An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia.” 2012. Web. 16 Feb 2020.

Vancouver:

Van Snellenberg JX. An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8TH8TSX.

Council of Science Editors:

Van Snellenberg JX. An Investigation of the Neural Correlates of Working Memory in Healthy Individuals and Individuals With Schizophrenia. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D8TH8TSX

Columbia University

22. Atanasova, Iliyana. Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease.

Degree: 2012, Columbia University

URL: https://doi.org/10.7916/D89W0NW9

► Peripheral arterial disease (PAD) is a major cause of morbidity and mortality in the USA with an estimated prevalence of up to 20% in those… (more)

Subjects/Keywords: Diagnostic imaging; Biomedical engineering

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APA (6^th Edition):

Atanasova, I. (2012). Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D89W0NW9

Chicago Manual of Style (16^th Edition):

Atanasova, Iliyana. “Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease.” 2012. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D89W0NW9.

MLA Handbook (7^th Edition):

Atanasova, Iliyana. “Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease.” 2012. Web. 16 Feb 2020.

Vancouver:

Atanasova I. Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D89W0NW9.

Council of Science Editors:

Atanasova I. Non-contrast Magnetic Resonance Angiography for Evaluation of Peripheral Arterial Disease. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D89W0NW9

Columbia University

23. Cohen, Ouri. In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain.

Degree: 2013, Columbia University

URL: https://doi.org/10.7916/D8639X3V

► Magnetic resonance spectroscopic imaging (MRSI) is a useful tool for obtaining information on the biochemical processes underlying various pathologies. A widely used multi-voxel localization method… (more)

▼ Magnetic resonance spectroscopic imaging (MRSI) is a useful tool for obtaining information on the biochemical processes underlying various pathologies. A widely used multi-voxel localization method is chemical shift imaging (CSI) which uses gradients for phase encoding. Although simple to implement, low in specific absorption rate (SAR) and immune to chemical shift displacement (CSD), it also suffers from some well known drawbacks caused by its sinc-shaped point spread function (PSF). This results in loss of both signal-to-noise ratio (SNR) as well as localization, an effect that is exacerbated at low resolutions. In contrast, an alternative localization method, Hadamard spectroscopic imaging (HSI) benefits from a theoretically ideal PSF and consequently does not suffer from these drawbacks. In this work we exploit the theoretically ideal PSF of HSI encoding to develop a novel three dimensional (3D) multi-voxel MR localization method based on transverse HSI (T-HSI). The advantages of T HSI are that unlike gradient phase-encoding: (i) the volume of interest (VOI) does not need to be smaller than the field-of-view to prevent aliasing; (ii) the number of partitions in each direction can be small, 8, 4 or even 2 at no cost in PSF; (iii) the VOI does not have to be contiguous; and (iv) the voxel profile depends on the available B1 and pulse synthesis paradigm and can therefore, at least theoretically, approach "ideal" "1" inside and "0" elsewhere. Clinical utility of the new method is shown by spectra obtained from the brain of a healthy volunteer. The benefits of T-HSI are demonstrated by a quantitative comparison to CSI of the SNR and localization in a phantom in both one and three dimensions at clinical resolutions. A novel matrix formalism is used to quantify the impact of non-ideal flip angles on T-HSI. The superior PSF of T-HSI is then used to demonstrate the feasibility of scanning regions near or on the skull while limiting the impact of lipid contamination and obtaining quantifiable spectra. A comparison to spectra obtained using CSI is shown for a healthy volunteer. The new method is also used in a clinical pathology: to scan multiple sclerosis (MS) lesions occurring near the skull. To maintain the benefits provided by the PSF of HSI at higher fields, despite its susceptibility to CSD, a additional hybrid sequence is also developed that limits both the SAR and the CSD, regardless of the size of the VOI. A comparison to CSI in a phantom and in-vivo is carried out and spectra obtained from the brain of a healthy volunteer at 3T are shown. Finally, future research avenues involving extension of this research to ultra high fields (7T) are discussed and possible clinical uses are described.

Subjects/Keywords: Biomedical engineering; Diagnostic imaging

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APA (6^th Edition):

Cohen, O. (2013). In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8639X3V

Chicago Manual of Style (16^th Edition):

Cohen, Ouri. “In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain.” 2013. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8639X3V.

MLA Handbook (7^th Edition):

Cohen, Ouri. “In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain.” 2013. Web. 16 Feb 2020.

Vancouver:

Cohen O. In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain. [Internet] [Doctoral dissertation]. Columbia University; 2013. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8639X3V.

Council of Science Editors:

Cohen O. In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain. [Doctoral Dissertation]. Columbia University; 2013. Available from: https://doi.org/10.7916/D8639X3V

Columbia University

24. Montejo, Ludguier. Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography.

Degree: 2014, Columbia University

URL: https://doi.org/10.7916/D8NS0S0C

► Diffuse optical tomography (DOT) is an imaging technique where near infrared (NIR) photons are used to probe biological tissue. DOT allows for the recovery of… (more)

▼ Diffuse optical tomography (DOT) is an imaging technique where near infrared (NIR) photons are used to probe biological tissue. DOT allows for the recovery of three-dimensional maps of tissue optical properties, such as tissue absorption and scattering coefficients. The application of DOT as a tool to aid in the diagnosis of rheumatoid arthritis (RA) is explored in this work. Algorithms for improving the image reconstruction process and for enhancing the clinical value of DOT images are presented in detail. The clinical data considered in this work consists of 99 fingers from subjects with RA and 120 fingers from healthy subjects. DOT scans of the proximal interphalangeal (PIP) joint of each finger is performed with modulation frequencies of 0, 300, and 600 MHz. A computer-aided diagnosis (CAD) framework for extracting heuristic features from DOT images and a method for using these same features to classify each joint as affected or not affected by RA is presented. The framework is applied to the clinical data and results are discussed in detail. Then, an algorithm for recovering the optical properties of biological media using the simplified spherical harmonics (SPN) light propagation model is presented. The computational performance of the algorithm is analyzed and reported. Finally, the SPN reconstruction algorithm is applied to clinical data of subjects with RA and the resulting images are analyzed with the CAD framework. As the first part of the CAD framework, heuristic image features are extracted from the absorption and the scattering coefficient images using multiple compression and dimensionality reduction techniques. Overall, 594 features are extracted from the images of each joint. Then, machine-learning techniques are used to evaluate the ability to discriminate between images of joints with RA and images of healthy joints. An evolution-strategy optimization algorithm is developed to evaluate the classification strength of each feature and to find the multidimensional feature combination that results in optimal classification accuracy. Classification is performed with k-nearest neighbors (KNN), linear (LDA) and quadratic discriminate analysis (QDA), self-organizing maps (SOM), or support vector machines (SVM). Classification accuracy is evaluated based on diagnostic sensitivity and specificity values. Strong evidence is presented that suggest there are clear differences between the tissue optical parameters of joints with RA and joints without RA. It is first shown that data obtained at 600 MHz leads to better classification results than data obtained at 300 and 0 MHz. Analysis of each extracted feature shows that DOT images of subjects with RA are statistically different (p < 0.05) from images of subjects without RA for over 90% of the features. Evidence shows that subjects with RA that do not have detectable signs of erosion, effusion, or synovitis (i.e. asymptomatic subjects) in MRI and US images have optical profiles similar to subjects who do have signs of erosion, effusion, or…

Subjects/Keywords: Biomedical engineering; Diagnostic imaging

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APA (6^th Edition):

Montejo, L. (2014). Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8NS0S0C

Chicago Manual of Style (16^th Edition):

Montejo, Ludguier. “Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography.” 2014. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8NS0S0C.

MLA Handbook (7^th Edition):

Montejo, Ludguier. “Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography.” 2014. Web. 16 Feb 2020.

Vancouver:

Montejo L. Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography. [Internet] [Doctoral dissertation]. Columbia University; 2014. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8NS0S0C.

Council of Science Editors:

Montejo L. Computational Methods For The Diagnosis of Rheumatoid Arthritis With Diffuse Optical Tomography. [Doctoral Dissertation]. Columbia University; 2014. Available from: https://doi.org/10.7916/D8NS0S0C

Columbia University

25. Jia, Jingfei. Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8KD1X4S

► It is well known that the radiative transfer equation (RTE) is the most accurate deterministic light propagation model employed in diffuse optical tomography (DOT). RTE-based… (more)

Subjects/Keywords: Biomedical engineering; Diagnostic imaging

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APA (6^th Edition):

Jia, J. (2015). Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8KD1X4S

Chicago Manual of Style (16^th Edition):

Jia, Jingfei. “Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems.” 2015. Doctoral Dissertation, Columbia University. Accessed February 16, 2020. https://doi.org/10.7916/D8KD1X4S.

MLA Handbook (7^th Edition):

Jia, Jingfei. “Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems.” 2015. Web. 16 Feb 2020.

Vancouver:

Jia J. Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2020 Feb 16]. Available from: https://doi.org/10.7916/D8KD1X4S.

Council of Science Editors:

Jia J. Fast Radiative-Transfer-Equation-Based Image Reconstruction Algorithms for Non-Contact Diffuse Optical Tomography Systems. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8KD1X4S

University of Oxford

26. Mózes, Ferenc Emil. Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:e428a3c3-b479-4b57-876c-795ad41b9cd1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780596

► Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent in the world population. The current gold standard for diagnosing NAFLD, however, is still the liver… (more)

Subjects/Keywords: Biophysical modelling; Diagnostic imaging

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APA (6^th Edition):

Mózes, F. E. (2018). Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:e428a3c3-b479-4b57-876c-795ad41b9cd1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780596

Chicago Manual of Style (16^th Edition):

Mózes, Ferenc Emil. “Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling.” 2018. Doctoral Dissertation, University of Oxford. Accessed February 16, 2020. http://ora.ox.ac.uk/objects/uuid:e428a3c3-b479-4b57-876c-795ad41b9cd1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780596.

MLA Handbook (7^th Edition):

Mózes, Ferenc Emil. “Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling.” 2018. Web. 16 Feb 2020.

Vancouver:

Mózes FE. Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2020 Feb 16]. Available from: http://ora.ox.ac.uk/objects/uuid:e428a3c3-b479-4b57-876c-795ad41b9cd1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780596.

Council of Science Editors:

Mózes FE. Magnetic resonance imaging of the liver : T1 dynamics : confounders and modelling. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:e428a3c3-b479-4b57-876c-795ad41b9cd1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780596

27. Skinner, J. G. Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging.

Degree: PhD, 2017, University of Nottingham

URL: http://eprints.nottingham.ac.uk/41416/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728460

► Spin-exchange optical pumping (SEOP) is a hyperpolarisation method used in the hyperpolarisation of noble gases and can enhance nuclear spin polarisation by five orders of… (more)

▼ Spin-exchange optical pumping (SEOP) is a hyperpolarisation method used in the hyperpolarisation of noble gases and can enhance nuclear spin polarisation by five orders of magnitude. Hyperpolarised (HP) 129-Xe has many properties that make it ideally suited to clinical lung imaging, but since its first demonstration in animals in 1994 and humans in 1996, translation to the clinic has been hampered by challenges associated with scaling up production. Within this thesis, construction and demonstration of a clinical-scale stopped-flow hyperpolariser is described, the design of which is based on the record holding XeUS and XeNA polarisers developed previously by our consortium, which had aimed to address the issue of production scale-up. Modifications enhancing the ease of operation and utility in-clinic are presented, as are modifications that reduce the capital cost of such a system. These include a re-design of the gas manifold and the development of a low-cost low-field NMR spectrometer which achieved an SNR of 125 at a cost of ~300, a 13-fold improvement in cost/SNR compared with the existing spectrometer at a saving of ~19,000. In continuous-flow 129-Xe polarisers there has long been a discrepancy in the polarisation achieved and that predicted by the standard model of SEOP which was shown recently to be due to the presence of rubidium clusters. Here, the standard model is applied to- and validated for the first time against the stopped-flow regime. The validated model is used to explore parameter space to identify the most effective ways to increase production yield in future stopped-flow polarisers. Stopped-flow SEOP in the xenon-rich regime presents unique thermal management problems due to the absence of gas flow and abundance of poorly thermally conductive, Rb spin destroying Xe. Raman spectroscopy is used to spatially examine in-cell thermal behaviour under steady-state and turbulent 'rubidium runaway' conditions as a function of temperature and Xe density and the beneficial impact of adding thermally conductive helium to the standard N2-Xe gas mix is demonstrated. Hybrid Rb-Cs-Xe SEOP is demonstrated for the first time and examined using in-situ NMR and Raman spectroscopies. High polarisations of ~50% were obtained. Finally, progress on the HP-Xe clinical trial is presented to illustrate the impact of the 4-fold increase in SNR that will come with the installation of the new N-XeUS stopped-flow polariser.

Subjects/Keywords: 616.07; WN Radiology. Diagnostic imaging

10 more images…

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APA (6^th Edition):

Skinner, J. G. (2017). Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/41416/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728460

Chicago Manual of Style (16^th Edition):

Skinner, J G. “Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging.” 2017. Doctoral Dissertation, University of Nottingham. Accessed February 16, 2020. http://eprints.nottingham.ac.uk/41416/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728460.

MLA Handbook (7^th Edition):

Skinner, J G. “Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging.” 2017. Web. 16 Feb 2020.

Vancouver:

Skinner JG. Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging. [Internet] [Doctoral dissertation]. University of Nottingham; 2017. [cited 2020 Feb 16]. Available from: http://eprints.nottingham.ac.uk/41416/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728460.

Council of Science Editors:

Skinner JG. Optimisation of xenon-rich stopped-flow spin-exchange optical pumping for functional lung imaging. [Doctoral Dissertation]. University of Nottingham; 2017. Available from: http://eprints.nottingham.ac.uk/41416/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728460

Florida State University

28. Zavala Romero, Olmo S. Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images.

Degree: PhD, Scientific Computing, 2015, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_2015fall_ZavalaRomero_fsu_0071E_12893 ;

►

A new method for the segmentation of 3D breast lesions in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) images, using parallel programming with general purpose… (more)

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A new method for the segmentation of 3D breast lesions in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) images, using parallel programming with general purpose computing on graphics processing units (GPGPUs), is proposed. The method has two main parts: a pre-processing step and a segmentation algorithm. In the pre-processing step, DCE-MRI images are registered using an intensity-based rigid transformation algorithm based on gradient descent. After the registration, voxels that correspond to breast lesions are enhanced using the Naïve Bayes machine learning classifier. This classifier is trained to identify four different classes inside breast images: lesion, normal tissue, chest and background. Training is performed by manually selecting 150 voxels for each of the four classes from images in which breast lesions have been confirmed by an expert in the field. Thirteen attributes obtained from the kinetic curves of the selected voxels are later used to train the classifier. Finally, the classifier is used to increase the intensity values of voxels labeled as lesions and to decrease the intensities of all other voxels. The post-processed images are used for volume segmentation of the breast lesions using a level set method based on the active contours without edges (ACWE) algorithm. The segmentation algorithm is implemented in OpenCL for the GPGPUs to accelerate the original model by parallelizing two main steps of the segmentation process: the computation of the signed distance function (SDF) and the evolution of the segmented curve. The proposed framework uses OpenGL to display the segmented volume in real time, allowing the physician to obtain immediate feedback on the current segmentation progress. The proposed implementation of the SDF is compared with an optimal implementation developed in Matlab and achieves speedups of 25 and 12 for 2D and 3D images, respectively. Moreover, the OpenCL implementation of the segmentation algorithm is compared with an optimal implementation of the narrow-band ACWE algorithm. Peak speedups of 55 and 40 are obtained for 2D and 3D images, respectively. The segmentation algorithm has been developed as open source software, with different versions for 2D and 3D images, and can be used in different areas of medical imaging as well as in areas within computer vision, such like tracking, robotics and navigation.

A Dissertation submitted to the Department of Scientific Computing in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Fall Semester 2015.

November 2, 2015.

GPU, Level Sets, OpenCL, OpenGL, Segmentation

Anke Meyer-Baese, Professor Directing Dissertation; Mark Sussman, University Representative; Gordon Erlebacher, Committee Member; Dennis Slice, Committee Member; Xiaoqiang Wang, Committee Member.

Advisors/Committee Members: Anke Meyer-Baese (professor directing dissertation), Mark Sussman (university representative), Gordon Erlebacher (committee member), Dennis E. Slice (committee member), Xiaoqiang Wang (committee member).

Subjects/Keywords: Diagnostic imaging; Radiography, Medical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zavala Romero, O. S. (2015). Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_2015fall_ZavalaRomero_fsu_0071E_12893 ;

Chicago Manual of Style (16^th Edition):

Zavala Romero, Olmo S. “Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images.” 2015. Doctoral Dissertation, Florida State University. Accessed February 16, 2020. http://purl.flvc.org/fsu/fd/FSU_2015fall_ZavalaRomero_fsu_0071E_12893 ;.

MLA Handbook (7^th Edition):

Zavala Romero, Olmo S. “Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images.” 2015. Web. 16 Feb 2020.

Vancouver:

Zavala Romero OS. Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images. [Internet] [Doctoral dissertation]. Florida State University; 2015. [cited 2020 Feb 16]. Available from: http://purl.flvc.org/fsu/fd/FSU_2015fall_ZavalaRomero_fsu_0071E_12893 ;.

Council of Science Editors:

Zavala Romero OS. Interactive 3D GPU-Based Breast Mass Lesion Segmentation Method Based on Level Sets for Dce-MRI Images. [Doctoral Dissertation]. Florida State University; 2015. Available from: http://purl.flvc.org/fsu/fd/FSU_2015fall_ZavalaRomero_fsu_0071E_12893 ;

Florida State University

29. Tahmassebi, Amirhessam. Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data.

Degree: PhD, Scientific Computing, 2018, Florida State University

URL: http://purl.flvc.org/fsu/fd/2018_Su_Tahmassebi_fsu_0071E_14652 ;

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Machine learning algorithms along with magnetic resonance imaging (MRI) provides promising techniques to overcome the drawbacks of the current clinical screening techniques. In this study… (more)

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Machine learning algorithms along with magnetic resonance imaging (MRI) provides promising techniques to overcome the drawbacks of the current clinical screening techniques. In this study the resting-state functional magnetic resonance imaging (fMRI) to see the level of activity in a patient's brain and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to explore the level of improvement of neo-adjuvant chemotherapy in patients with locally advanced breast cancer were considered. As the first project, we considered fMRI of patients before and after they underwent a double-blind smoking cessation treatment. For the first time, this study aims at developing new theory-driven biomarkers by implementing and evaluating novel techniques from resting-state scans that can be used in relapse prediction in nicotine-dependent patients and future treatment efficacy. In this regards, two classes of patients have been studied, one took the drug N-acetylcysteine and the other took a placebo. Our goal was to classify the patients as treatment or non-treatment, based on their fMRI scans. The image slices of brain are used as the variable. We have applied different voxel selection schemes and data reduction algorithms on all images. Then, we compared several multivariate classifiers and deep learning algorithms and also investigated how the different data reductions affect classification performance. For the second part, we have employed multi-parametric magnetic resonance imaging (mpMRI) using different morphological and functional MRI parameters such as T2-weighted, dynamic contrast-enhanced (DCE) MRI, and diffusion weighted imaging (DWI) has emerged as the method of choice for the early response assessments to NAC. Although, mpMRI is superior to conventional mammography for predicting treatment response, and evaluating residual disease, yet there is still room for improvement. In the past decade, the field of medical imaging analysis has grown exponentially, with an increased numbers of pattern recognition tools, and an increase in data sizes. These advances have heralded the field of radiomics. Radiomics allows the high-throughput extraction of the quantitative features that result in the conversion of images into mineable data, and the subsequent analysis of the data for an improved decision support with response monitoring during NAC being no exception. In this study. we determined the importance and ranking of the extracted parameters from mpMRI using T2-weighted, DCE, and DWI for prediction of pCR and patient outcomes with respect to metastases and disease-specific death employing different machine learning algorithms.

A Dissertation submitted to the Department of Scientific Computing in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Summer Semester 2018.

July 6, 2018.

Breast Cancer, Data Mining, Machine Learning, Medical Imaging, Neuroimaging

Anke Meyer-Baese, Professor Directing Dissertation; Simon Y. Foo, University Representative; Katja Pinker-Domenig, Committee…

Advisors/Committee Members: Anke Meyer-Bäse (professor directing dissertation), Simon Y. Foo (university representative), Katja Pinker-Domenig (committee member), Peter Beerli (committee member), Dennis E. Slice (committee member).

Subjects/Keywords: Diagnostic imaging; Radiography, Medical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tahmassebi, A. (2018). Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/2018_Su_Tahmassebi_fsu_0071E_14652 ;

Chicago Manual of Style (16^th Edition):

Tahmassebi, Amirhessam. “Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data.” 2018. Doctoral Dissertation, Florida State University. Accessed February 16, 2020. http://purl.flvc.org/fsu/fd/2018_Su_Tahmassebi_fsu_0071E_14652 ;.

MLA Handbook (7^th Edition):

Tahmassebi, Amirhessam. “Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data.” 2018. Web. 16 Feb 2020.

Vancouver:

Tahmassebi A. Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data. [Internet] [Doctoral dissertation]. Florida State University; 2018. [cited 2020 Feb 16]. Available from: http://purl.flvc.org/fsu/fd/2018_Su_Tahmassebi_fsu_0071E_14652 ;.

Council of Science Editors:

Tahmassebi A. Pattern Recognition in Medical Imaging: Supervised Learning of fMRI and MRI Data. [Doctoral Dissertation]. Florida State University; 2018. Available from: http://purl.flvc.org/fsu/fd/2018_Su_Tahmassebi_fsu_0071E_14652 ;

Rutgers University

30. Alamoudi, Abdullah Othman, 1985-. The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients.

Degree: PhD, Biomedical Informatics, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48228/

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Among the several factors related to high mortality, imaging methods and intervention procedures could be important. American College of Radiologists (ACR) prescribed some appropriateness guidelines… (more)

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Among the several factors related to high mortality, imaging methods and intervention procedures could be important. American College of Radiologists (ACR) prescribed some appropriateness guidelines for diagnostic imaging. Not complying with them fully or partially may also be a mortality factor. The present study was undertaken to investigate these aspects. NIS data for the period of 2008-2012 using ICD-9 codes were obtained for 6 types of aneurysms- intact and ruptured Abdominal Aortic Aneurysm (AAA), Thoracic Aneurysm and Thoracio-Abdominal Aneurysm; four imaging methods: Computerized Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasound (US) and Digital Subtraction Angiography (DSA) as diagnostic imaging methods; EVAR or OAR as the intervention procedures; patient characteristic factors of age, gender, race, comorbidities and insurance type; and hospital context factors of size, location and teaching status, region and admission type. The dependent variables were total, died in hospital and did not die frequencies patients. Data on 38263 patients were obtained from this search from more than 4,300 participating hospitals. The data were analyzed using SPSS22 software using descriptive statistics, ANOVA, logistic multiple regression test, Chi square test, McNemar test and Gamma test. AAA was most frequent (73.4%) followed by TA (20.6%). All ruptured aneurysms together constituted only about 3.4%. Very few cases of ruptured aneurysms affected precise evaluation of high mortality due to rupture. About 63% aneurysms were repaired using OAR and only 23% cases were treated by EVAR. Increasing popularity of EVAR was not reflected in this data. Among the imaging methods, DSA was used in about 86% cases and US was used in 13% cases. Always DSA was highest followed by US, CT and MRI in the decreasing order. Higher numbers of younger age group patients (65-79) were imaged using DSA and US. More numbers of older patients were imaged using CT and MRI (70-84). Whites, blacks and Hispanics were the highest three percentages among the races. About 70% of all aneurysm patients were males. Most patients were covered by Medicare or Medicaid or private insurance. Only 2% patients met their expenses on their own. Among comorbidities, hypertension, diabetes, heart failure and anaemia were more common. All objectives were achieved. Effect of imaging methods and its interaction with interventional procedures in reducing in-hospital mortality rates were demonstrated. Compliance with ACR appropriateness helps to reduce mortality rates. Age groups and comorbidities of patient characteristics influenced mortality rate more effectively. Linear logistic equations for odds for dying against imaging methods, its interaction with intervention procedures, ACR compliance level, patient age and comorbidities and some hospital contexts were developed. Limitations of this research and future scope of research have also been discussed.

Advisors/Committee Members: Srinivasan, Shankar (chair), Haque,, Syed S (internal member), Coffman,, Frederick (internal member), School of Health Related Professions.

Subjects/Keywords: Aortic aneurysms; Diagnostic imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alamoudi, Abdullah Othman, 1. (2015). The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48228/

Chicago Manual of Style (16^th Edition):

Alamoudi, Abdullah Othman, 1985-. “The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients.” 2015. Doctoral Dissertation, Rutgers University. Accessed February 16, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/48228/.

MLA Handbook (7^th Edition):

Alamoudi, Abdullah Othman, 1985-. “The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients.” 2015. Web. 16 Feb 2020.

Vancouver:

Alamoudi, Abdullah Othman 1. The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2020 Feb 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48228/.

Council of Science Editors:

Alamoudi, Abdullah Othman 1. The influence of different diagnostic imaging and interventional repair techniques on mortality rate in aortic aneurysm patients. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48228/

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