You searched for subject:(Diabetes ).
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1.
Agik, Sandra.
DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S.
Degree: Department of Epidemiology, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733255/ 
► Background: Several studies have reported an increased risk of abnormal Pap smears and cervical cancer in populations of women with immunocompromised health, such as in…
(more)
▼ Background: Several studies have reported an increased
risk of abnormal Pap smears and cervical cancer in populations of
women with immunocompromised health, such as in women with HIV or
Inflammatory Bowel Disease. Metabolic abnormalities in women with
diabetes are known to lower immunity and, through other pathways,
result in an increased risk of abnormal Pap smears. In this study,
we determined the risk of abnormal Pap smears in black women with
diabetes and compared this risk between foreign-born and U.S.-born
black women. Methods: Combined cross-sectional survey data from the
2010 and 2015 National Health Information Survey (NHIS) was used.
Women aged 21 to 69 years who reported African-American/black
ancestry and had received a Pap smear test within 3 years prior to
the survey interview were included in the study (n=3,473). Odds
ratios (ORs) of abnormal Pap smears in women with
diabetes were
calculated using a weighted logistic regression. Results: 518 (15%)
women reported having had an abnormal Pap smear within 3 years
prior to the survey interview.
Diabetes was not associated with
abnormal Pap smears in black women living in the U.S. (OR=0.86; 95%
CI=0.54-1.39). Stratification by nativity showed no association
between
diabetes and abnormal Pap smears in either the U.S.-born
black women (OR=0.82; 95% CI=0.50-1.34) or foreign-born black women
(OR=1.01; 95% CI=0.26-3.87). Risk factors associated with abnormal
Pap smears were different for U.S.-born black women compared to
foreign-born black women. Conclusion: There was no significant
association between
diabetes and abnormal Pap smears in black women
living in the U.S. regardless of place of birth. Further studies
should be conducted to evaluate the risk of abnormal Pap smears in
black women with
diabetes as findings could have implications on
screening guidelines in this group of women.
Advisors/Committee Members: Pearlman, Deborah (Advisor), Kelsey, Karl (Reader).
Subjects/Keywords: Diabetes
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APA (6th Edition):
Agik, S. (2017). DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733255/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Agik, Sandra. “DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S.” 2017. Thesis, Brown University. Accessed April 17, 2021.
https://repository.library.brown.edu/studio/item/bdr:733255/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Agik, Sandra. “DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S.” 2017. Web. 17 Apr 2021.
Vancouver:
Agik S. DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 17].
Available from: https://repository.library.brown.edu/studio/item/bdr:733255/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Agik S. DIABETES MELLITUS AND THE RISK OF ABNORMAL PAP SMEARS IN
FOREIGN- AND U.S.-BORN BLACK WOMEN LIVING IN THE U.S. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733255/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Lacy, Mary.
Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c.
Degree: Department of Epidemiology, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:792590/
► Abstract of Diabetes Screening and Diagnosis in African Americans: The role of hemoglobin A1c, by Mary E. Lacy, Ph.D., Brown University, May 2018. African Americans…
(more)
▼ Abstract of
Diabetes Screening and Diagnosis in
African Americans: The role of hemoglobin A1c, by Mary E. Lacy,
Ph.D., Brown University, May 2018. African Americans have higher
rates of
diabetes and a number of
diabetes complications than
whites. In 2010, hemoglobin A1c was added to the diagnostic
criteria for
diabetes despite known racial differences in
hemoglobin A1c values. This dissertation examined whether or not
racial differences in hemoglobin A1c values impact our ability to
identify those at increased
diabetes risk and studied underlying
factors that are potentially contributing to racial differences in
hemoglobin A1c. In chapter 1, we used data from a biracial
community based cohort study (the CARDIA study) to compare the
performance of existing incident
diabetes prediction models. We
found significant racial differences in the performance of
diabetes
prediction models to identify those at increased risk of developing
diabetes. Importantly, racial differences were more pronounced in
models that incorporated hemoglobin A1c suggesting the need to
further evaluate the potential causes and implications of racial
differences in hemoglobin A1c. In chapter 2, we used data collected
on African Americans from two large community based cohort studies
(the CARDIA study and the Jackson Heart Study) to examine one
particular condition that may be differentially impacting
hemoglobin A1c in African Americans, sickle cell trait. We found
that sickle cell trait interfered with accurate assessment of
hemoglobin A1c in African Americans which was resulting in an
underestimation of glycemia in those with sickle cell trait. In
chapter 3, we, again, used data from CARDIA and the Jackson Heart
Study to examine whether or not this underestimation of glycemia in
African Americans with sickle cell trait was impacting
identification of incident cases of
diabetes and prediabetes. We
found that, among African Americans with sickle cell trait compared
to those without, the 10-year incidence of
diabetes and prediabetes
was significantly lower when using hemoglobin A1c to identify
cases. Overall, these findings suggest that hemoglobin A1c alone
may not represent the best tool for screening and diagnosing
diabetes in African Americans, particularly for those with sickle
cell trait or whose sickle cell status is unknown.
Advisors/Committee Members: Wu, Wen-Chih (Advisor), Wellenius, Gregory (Reader), Eaton, Charles (Reader), Gjelsvik, Annie (Reader), Luo, Xi (Reader).
Subjects/Keywords: Diabetes
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APA (6th Edition):
Lacy, M. (2017). Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792590/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lacy, Mary. “Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c.” 2017. Thesis, Brown University. Accessed April 17, 2021.
https://repository.library.brown.edu/studio/item/bdr:792590/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lacy, Mary. “Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c.” 2017. Web. 17 Apr 2021.
Vancouver:
Lacy M. Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 17].
Available from: https://repository.library.brown.edu/studio/item/bdr:792590/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lacy M. Diabetes screening and diagnosis in African Americans: The
role of hemoglobin A1c. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:792590/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wake Forest University
3.
Dover, Ellen Nicole.
Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells.
Degree: 2015, Wake Forest University
URL: http://hdl.handle.net/10339/57111
► Estrogen receptor signaling is involved in the etiology of multiple diseases including the development and progression of Type 2 Diabetes Mellitus, T2DM. The role of…
(more)
▼ Estrogen receptor signaling is involved in the etiology of multiple diseases including the development and progression of Type 2 Diabetes Mellitus, T2DM. The role of estrogen receptor signaling in peripheral insulin resistance has been shown through studies in post-menopausal women; however, estrogen receptor signaling in the β-cell is less understood. Conflicting data have arisen that demonstrate estrogen receptor signaling in the β-cell has either no effect, a protective effect against induced stress, or deleterious effects after long term activation of signaling. The present study aimed to elucidate the role of estrogen receptor isoform and variant signaling on the health and function of pancreatic β-cells. The variants of ERα differ in the presence of two activation function (AF) domains, which regulate transcriptional activities. ERα66 possesses both domains, ERα46 lacks the AF-1 domain, and ERα36 lacks both the AF-1 and AF-2 domains. Expression of ERα66 induced constitutive ERE-dependent transcriptional activity, which was correlated to an increase in pancreatic β-cell death as observed through high throughput imaging analysis and apoptotic endpoint assays (caspase 3/7). ERα46 expression resulted in increased transcriptional and caspase 3/7 activity similar to ERα66. Interestingly, in all assays ERα46 was more sensitive to ligand treatment than ERα66, suggesting an inherent difference in the ligand responsiveness between these two variants in the INS-1E cell line. ERα36 did not significantly alter transcriptional or caspase 3/7 activity. Expression of the estrogen receptor isoform, ERβ, increased ERE-dependent transcriptional activity and caspase 3/7 activity, however the magnitude of activation was less than ERα. Expanding these assays into human islets revealed that raloxifene treatment results in a significant increase in insulin mRNA expression as well as differentially regulating genes that may be involved in β-cell health. In addition to testing isoforms and variants, coregulator interaction with the receptors was also assessed. The coregulator, NCoA5, significantly potentiated ERα66 activity, but had no significant effect on ERα46 or ERβ implying a dependence on the AF-1 domain. Overall, this study elucidates that genomic estrogen receptor signaling is deleterious to β-cell health and function.
Subjects/Keywords: Diabetes
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Manager
APA (6th Edition):
Dover, E. N. (2015). Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dover, Ellen Nicole. “Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells.” 2015. Thesis, Wake Forest University. Accessed April 17, 2021.
http://hdl.handle.net/10339/57111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dover, Ellen Nicole. “Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells.” 2015. Web. 17 Apr 2021.
Vancouver:
Dover EN. Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10339/57111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dover EN. Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wake Forest University
4.
Knutson, Dylan Thomas.
NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM.
Degree: 2017, Wake Forest University
URL: http://hdl.handle.net/10339/82259
► Propulsion in the gut is orchestrated by a rhythmic complex called the neuromuscular apparatus which includes smooth muscle, enteric neurons, and interstitial cells of Cajal…
(more)
▼ Propulsion in the gut is orchestrated by a rhythmic complex called the neuromuscular apparatus which includes smooth muscle, enteric neurons, and interstitial cells of Cajal (ICC). Depletions of these cell populations are associated with several motility disorders, and their significant effects on function are uncertain. In this thesis, several different approaches are studied to understand the relationship of each key gastrointestinal cell to tissue function. Here, the focus is on the specific contribution of each cell population to tissue function using physiology of ex vivo tissue, bioengineered tissues, and a 3D printed platform. Initiation of muscular relaxation was dependent on a functional neural population. Then, ICC transduced neural-mediated relaxation through electrical pacing, in order to relax muscle with enhanced rhythm and coordination. These promising models can provide approaches for an investigator test new hypotheses by modeling clinical populations to study, alter, or repair function.
Subjects/Keywords: Diabetes
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APA (6th Edition):
Knutson, D. T. (2017). NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/82259
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Knutson, Dylan Thomas. “NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM.” 2017. Thesis, Wake Forest University. Accessed April 17, 2021.
http://hdl.handle.net/10339/82259.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Knutson, Dylan Thomas. “NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM.” 2017. Web. 17 Apr 2021.
Vancouver:
Knutson DT. NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM. [Internet] [Thesis]. Wake Forest University; 2017. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10339/82259.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Knutson DT. NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM. [Thesis]. Wake Forest University; 2017. Available from: http://hdl.handle.net/10339/82259
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
5.
Mwauseya, Tamishe.
The patients explanatory models of diabetes at the university teaching hosipital in lusaka
.
Degree: 2016, University of Zambia
URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/5062
► Introduction: Despite concordance between the Explanatory Models of patients and those of the health care providers showing a positive impact on patient’s outcomes and self-care,…
(more)
▼ Introduction: Despite concordance between the Explanatory Models of patients and those of the health care providers showing a positive impact on patient’s outcomes and self-care, little is known about the patients’ Explanatory Models of diabetes in Zambia. It is, therefore, important, that this study on understanding the patient’s explanatory models of diabetes at the University Teaching Hospital in Lusaka is explored.
Methodology: The study took a qualitative approach in particular case study. The area of study was UTH Clinic Five. Data was collected through in-depth interviews in which 20 adults above the age of 18 were interviewed. The interviews were audiotaped, transcribed verbatim and coded into themes which were informed by Kleinman’s explanatory models of disease. Data was then analysed using thematic analysis. Ethical clearance was sought from Excellency in Research Ethics and Science (ERES) with reference number 2014-May-037.
Results: The study found that most diabetes patients associate the cause of diabetes to consumption causes, biological causes such as genetics, psychosocial stress and supernatural causes such as witchcraft. It was also reviewed in this study that the diabetes patients’ understanding of the signs of diabetes was similar to the biomedical information although the patients understood the signs of diabetes through body listening other than from biomedical information availed to them. In the study, participants mentioned two categories of treatment which were traditional and conventional treatment. Following good diet was the commonly mentioned way of diabetes prevention. The study revealed that the diabetes patients had challenges with the availability of authentic information on the cause, signs, treatment, and prevention of diabetes. The study also established that there was a need to scale up availing authentic information to the patients which would be very helpful to their self-management and care for the disease.
Conclusion: The study showed that despite some of the similarities between the patients’ explanatory models of diabetes and that of the biomedical model, the patients drew their explanatory model mainly from their experience through body listening and observation from the fellow patients’ experiences.
Subjects/Keywords: Diabetes
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APA ·
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Manager
APA (6th Edition):
Mwauseya, T. (2016). The patients explanatory models of diabetes at the university teaching hosipital in lusaka
. (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/5062
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mwauseya, Tamishe. “The patients explanatory models of diabetes at the university teaching hosipital in lusaka
.” 2016. Thesis, University of Zambia. Accessed April 17, 2021.
http://dspace.unza.zm:8080/xmlui/handle/123456789/5062.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mwauseya, Tamishe. “The patients explanatory models of diabetes at the university teaching hosipital in lusaka
.” 2016. Web. 17 Apr 2021.
Vancouver:
Mwauseya T. The patients explanatory models of diabetes at the university teaching hosipital in lusaka
. [Internet] [Thesis]. University of Zambia; 2016. [cited 2021 Apr 17].
Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/5062.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mwauseya T. The patients explanatory models of diabetes at the university teaching hosipital in lusaka
. [Thesis]. University of Zambia; 2016. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/5062
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Oxford
6.
Spiliotis, Ioannis.
Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus.
Degree: PhD, 2018, University of Oxford
URL: http://ora.ox.ac.uk/objects/uuid:2c67c074-3607-4174-98fb-2a8ee97eb122
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780478
► <b>Background:</b> Diabetes is a multi-hormonal disorder characterised by insufficient insulin secretion and aberrant glucagon secretion with fasting hyperglucagonaemia leading to increased rates of hepatic glucose…
(more)
▼ <b>Background:</b> Diabetes is a multi-hormonal disorder characterised by insufficient insulin secretion and aberrant glucagon secretion with fasting hyperglucagonaemia leading to increased rates of hepatic glucose production, which further exacerbates hyperglycaemia. Sulfonylureas used at low concentrations have been shown to partially restore appropriate glucose-regulated glucagon secretion in isolated islets from donors with type 2 diabetes (T2DM). The main objective of this thesis was to investigate whether low doses of the sulfonylurea glibenclamide could reduce fasting hyperglucagonaemia in patients with T2DM. In addition, the effect of age and sex on islet hormone secretion was examined in human islets, as was the impact of low-dose gliclazide (another sulfonylurea) on glucagon secretion in MODY patients. <b>Methods:</b> I performed a pilot, dose-finding (0.3mg - 6mg/day) clinical trial (LEGEND-A) of a novel oral glibenclamide suspension in sixteen patients with T2DM (diet controlled or on metformin alone). Fasting plasma glucagon, glucose, insulin, C-peptide and glibenclamide were measured at each dose-change, and continuous glucose monitoring was used throughout. For the human islet hormone secretion study, a database analysis was performed which covered an 11-year period (2006-2017). Finally, a pilot clinical study ("Glucagon in MODY") involving an oral glucose tolerance test before and after the omission of gliclazide for 72h was performed in three patients diagnosed with HNF1-α MODY (study ongoing). <b>Results:</b> Glibenclamide at 0.3mg/day was able to reduce fasting glucagon levels by 30% in four T2DM patients who had hyperglucagonaemia, without causing insulin secretion and with no adverse effects. This effect was not observed at higher glibenclamide concentrations, nor in the twelve T2DM patient who had normal-range fasting glucagon levels. In addition, the islet hormone database analysis revealed the novel finding that islets from older donors (especially males) secreted twice as much insulin at euglycaemic conditions as those from younger donors, but only 40% as much glucagon when challenged with hypoglycaemic conditions. Finally, the preliminary results of the "Glucagon in MODY" study suggest that HNF1-α MODY patients may not display appropriate glucose-dependent glucagon suppression during an oral glucose tolerance test, and that this may be reinstated by using low doses of gliclazide. <b>Conclusions:</b> Using low-dose sulfonylureas it may be possible to normalise aberrant glucagon secretion patterns in patients with diabetes, perhaps by subtly altering the activity of the alpha-cell ATP-sensitive potassium channel. This novel approach has the potential to be used both as a standalone therapy and as an adjunct to other medications, such as SGLT2 inhibitors, in which a reduction in glucagon could increase overall efficiency. I have also demonstrated that age and sex can impact the secretion of insulin and glucagon in ex vivo human islets, and this may in part provide a mechanistic explanation for…
Subjects/Keywords: Diabetes
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APA ·
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CSE |
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Manager
APA (6th Edition):
Spiliotis, I. (2018). Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:2c67c074-3607-4174-98fb-2a8ee97eb122 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780478
Chicago Manual of Style (16th Edition):
Spiliotis, Ioannis. “Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus.” 2018. Doctoral Dissertation, University of Oxford. Accessed April 17, 2021.
http://ora.ox.ac.uk/objects/uuid:2c67c074-3607-4174-98fb-2a8ee97eb122 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780478.
MLA Handbook (7th Edition):
Spiliotis, Ioannis. “Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus.” 2018. Web. 17 Apr 2021.
Vancouver:
Spiliotis I. Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Apr 17].
Available from: http://ora.ox.ac.uk/objects/uuid:2c67c074-3607-4174-98fb-2a8ee97eb122 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780478.
Council of Science Editors:
Spiliotis I. Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:2c67c074-3607-4174-98fb-2a8ee97eb122 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780478
University of Hawaii – Manoa
7.
Lindo, Jaclyn Keiko.
Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101480
► Ph.D. University of Hawaii at Manoa 2011.
Chapter 1 uses the 2004 to 2008 Medical Expenditure Panel Survey to estimate the difference in annual medical…
(more)
▼ Ph.D. University of Hawaii at Manoa 2011.
Chapter 1 uses the 2004 to 2008 Medical Expenditure Panel Survey to estimate the difference in annual medical expenditures between diabetics and non-diabetics. Various propensity score matching methods demonstrate that an adult diagnosed with diabetes incurs annual expenditures $2,900 higher than an otherwise identical non-diabetic. By splitting the diabetic sample into 8 treatment groups by diabetes comorbidity combination, it is clear that heart disease causes the largest increase in expenditures of diabetics compared to other comorbidities.
Chapter 2 analyzes the diabetes expenditure differential over progression of the disease. Using propensity score matching, diabetes progression is defined both by disease duration and severity, as measured by treatment regimen. A persistent, statistically significant increase in the expenditure differential is estimated over diabetes duration quartile, with prescription drug, hospital and office-based provider expenditures of diabetics all increasing relative to those of non-diabetics. While diabetics treated with insulin incur the highest expenditures relative to non-diabetics, those treated with a diet modification alone are estimated to incur higher expenditures relative to non-diabetics than diabetics on a regimen of oral medication.
Chapter 3 evaluates the effect of State Children's Health Insurance Program (SCHIP) expansion on insurance coverage in Hawaii using the 1998 to 2008 Current Population Survey. A model-based difference-in-differences approach compares changes in insurance coverage between the group of SCHIP-targeted children and a control group consisting of children for whom eligibility remained constant over the period of analysis. We estimate a 20 percent take-up rate of SCHIP and an 87 percent crowd-out rate of private insurance among newly-eligible children.
Subjects/Keywords: diabetes
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APA ·
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APA (6th Edition):
Lindo, J. K. (2016). Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101480
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lindo, Jaclyn Keiko. “Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi.” 2016. Thesis, University of Hawaii – Manoa. Accessed April 17, 2021.
http://hdl.handle.net/10125/101480.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lindo, Jaclyn Keiko. “Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi.” 2016. Web. 17 Apr 2021.
Vancouver:
Lindo JK. Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10125/101480.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lindo JK. Essays on the economic burden of diabetes and the effect of schip expansion on insurance coverage in Hawaiʻi. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101480
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hawaii – Manoa
8.
Kihmm Connolly, Kathleen Hansook.
The digital divide and health outcomes : a teleretinal imaging study.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101899
► Ph.D. University of Hawaii at Manoa 2013.
The purpose of this research project was to understand, explore and describe the digital divide and the relationship…
(more)
▼ Ph.D. University of Hawaii at Manoa 2013.
The purpose of this research project was to understand, explore and describe the digital divide and the relationship between technology utilization and health outcomes. Diabetes and diabetic eye disease was used as the real-life context for understanding change and exploring the digital divide. As an investigational framework, a telemedicine intervention in the form of a diabetic eye care program that utilized web-based eye care education and retinal (teleretinal) imaging over the Internet was implemented. Research has shown that minority and underserved populations in which technology has been made available demonstrate improved their health outcomes.
The participant population for this study was recruited from a Federally Qualified Health Center that serves a Federal Medically Underserved Area. Data sources included: 1) surveys using the transtheoretical model (TTM), which were used to explore behavior change as a result of the technology intervention; and 2) focus groups to further explore computer and Internet usage, and to further examine how technology impacted health and health outcomes.
Results from the TTM surveys revealed statistically significant differences in readiness to change for exercise, carbohydrate counting and smoking cessation over a three-month period. For the measure of daily self-management there was a significant difference in the transition from having no self-management plan to having a plan. There were also significant differences in decisional balance for exercise adoption and carbohydrate counting. Significant changes in TTM-based processes of change were mainly related to social interaction, such as: 1) environmental reevaluation, which addresses the impact of the social environment on behavior; 2) helping relationships, which involves seeking and using social support; and 3) social liberation, which relates to recognizing changes in social norms.
Based on the focus group interviews, all participants felt that their study participation had been a positive experience. All focus group participants agreed that the retinal imaging was not invasive and provided little discomfort.
Family was a key theme in the use of computers, improving eHealth literacy, and a key influence as a motivator and barrier for health behavior change. Family was also a key factor in the concept of fear being a motivating factor for behavior change. Fear that they did not want to suffer from the complications of diabetes like other family members had experienced.
Additionally, social support was confirmed as a key theme as a motivator for behavior change. Barriers to behavior change included the lack of support from family, food, culture and depression. The food culture of the participants was a theme that impacted the participants a great deal: the love for food; the lack of control when it came to eating; and the culturally high-fat foods that were pervasive in their environment. Symptoms of depression were also key barriers: low self-esteem, lack of confidence,…
Subjects/Keywords: diabetes
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APA (6th Edition):
Kihmm Connolly, K. H. (2016). The digital divide and health outcomes : a teleretinal imaging study. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101899
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kihmm Connolly, Kathleen Hansook. “The digital divide and health outcomes : a teleretinal imaging study.” 2016. Thesis, University of Hawaii – Manoa. Accessed April 17, 2021.
http://hdl.handle.net/10125/101899.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kihmm Connolly, Kathleen Hansook. “The digital divide and health outcomes : a teleretinal imaging study.” 2016. Web. 17 Apr 2021.
Vancouver:
Kihmm Connolly KH. The digital divide and health outcomes : a teleretinal imaging study. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10125/101899.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kihmm Connolly KH. The digital divide and health outcomes : a teleretinal imaging study. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101899
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hawaii – Manoa
9.
Hsu, Laura Jy.
An examination of influential factors in diabetes prevention efforts.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101845
► D.P.H. University of Hawaii at Manoa 2013.
Type 2 Diabetes Mellitus (hereafter referred to as "diabetes") is a growing public health concern in the United…
(more)
▼ D.P.H. University of Hawaii at Manoa 2013.
Type 2 Diabetes Mellitus (hereafter referred to as "diabetes") is a growing public health concern in the United States (U.S.), making prevention a priority. An estimated 79 million U.S. adults (35% of adults) have pre-diabetes, a health condition that denotes a high risk for diabetes, surpassing the number of adults who have diabetes. Clinical trials have shown that diabetes can be prevented in individuals with pre-diabetes through lifestyle health behaviors including weight loss, physical activity, and diet/nutrition. Understanding the factors that influence diabetes prevention is important in efforts to improve the health of at-risk individuals.
This three-part dissertation aimed to better understand the influential factors in diabetes prevention efforts and the implications for chronic disease prevention. Through a secondary data analysis of the National Health and Nutrition Examination Survey (NHANES), the first study quantitatively examined the impact of risk awareness on physical activity and diet in pre-diabetic individuals. The second study used survival/time-to-event analysis and data from the epidemiological Kohala Health Study to investigate the predictive ability of the metabolic syndrome in Native Hawaiians at risk for diabetes. The third study used qualitative methods to identify the salient factors that influence the perceptions of potential adopters on lifestyle interventions, and how the identified issues affect the implementation of lifestyle interventions.
Together, these three studies suggest that in order to decrease diabetes incidence, prevention efforts will need to extend beyond the education and awareness efforts at the individual-interpersonal level (i.e. prevention programs), and address the broader environmental context (i.e. public policies, community norms, organizational values). Individual-level prevention programs will need to be complemented by population-based strategies that seek to minimize the underlying causes of diabetes.
Subjects/Keywords: diabetes
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APA (6th Edition):
Hsu, L. J. (2016). An examination of influential factors in diabetes prevention efforts. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101845
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hsu, Laura Jy. “An examination of influential factors in diabetes prevention efforts.” 2016. Thesis, University of Hawaii – Manoa. Accessed April 17, 2021.
http://hdl.handle.net/10125/101845.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hsu, Laura Jy. “An examination of influential factors in diabetes prevention efforts.” 2016. Web. 17 Apr 2021.
Vancouver:
Hsu LJ. An examination of influential factors in diabetes prevention efforts. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10125/101845.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hsu LJ. An examination of influential factors in diabetes prevention efforts. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101845
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hawaii – Manoa
10.
Wakida, Richelle Michie.
Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting.
Degree: 2015, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101155
► Ph.D. University of Hawaii at Manoa 2014.
Health disparities are documented among Hawaiʻi's multi-ethnic adult population diagnosed with diabetes mellitus type 2. The findings of…
(more)
▼ Ph.D. University of Hawaii at Manoa 2014.
Health disparities are documented among Hawaiʻi's multi-ethnic adult population diagnosed with diabetes mellitus type 2. The findings of the current study suggested the HMO model in the State of Hawaiʻi may be potentially effective in addressing racial/ethnic disparities in compliance. In terms of age and compliance in appointment keeping, findings suggested that disparities continued to exist even among patients who have medical insurance coverage as well as access to health care. Taken together, these findings have important implications for social policy and practice. The findings of the study have demonstrated that racial/ethnic disparities can be alleviated in certain health care settings with the appropriate practices in place. For example, Kaiser Permanente's integrated approach with a client centered focus may have important implications in care delivery in terms of provider-patient relationship, communication, and treatment of racial/ ethnic older adults diagnosed with diabetes mellitus type 2. This study contributed to the knowledge in disparities in health and health care as well as factors affecting compliance in appointment keeping. Moreover, it formed the foundation to which other studies may be predicated on in the future.
Subjects/Keywords: diabetes
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APA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Wakida, R. M. (2015). Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101155
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wakida, Richelle Michie. “Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting.” 2015. Thesis, University of Hawaii – Manoa. Accessed April 17, 2021.
http://hdl.handle.net/10125/101155.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wakida, Richelle Michie. “Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting.” 2015. Web. 17 Apr 2021.
Vancouver:
Wakida RM. Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting. [Internet] [Thesis]. University of Hawaii – Manoa; 2015. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10125/101155.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wakida RM. Examining disparities in compliance in appointment keeping among older adult's with diabetes mellitus type 2 within a managed care setting. [Thesis]. University of Hawaii – Manoa; 2015. Available from: http://hdl.handle.net/10125/101155
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
Musale, Vishal.
Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes.
Degree: PhD, 2019, Ulster University
URL: https://ulster.pure.elsevier.com/en/studentTheses/b0439836-cc81-42c5-8bd8-c62cfa2938a0
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793762
► Amphibian skin secretions are a rich source of biomolecules (peptides, alkaloids and biogenic amines) which play a significant role in protecting the host from predators…
(more)
▼ Amphibian skin secretions are a rich source of biomolecules (peptides, alkaloids and biogenic amines) which play a significant role in protecting the host from predators microbial attack. Peptides from frog skin secretions have shown antimicrobial activity against a wide range of microorganisms. Also, these peptides have been shown to possess anticancer, immunomodulatory and insulinotropic activities. In this thesis, peptides from skin secretions of frogs belonging to the family of Alytidae, Hylidae, Pipidae, and Ranidae were examined for insulinotropic and antidiabetic activities. Frenatin 2D and its synthetic analogues from <i>Discoglossus sardus, </i>[A14K] and [S4K] analogues of PGLa-AM1 and CPF-AM1 respectively from <i>Xenopus amieti, </i>temporin peptides from <i>Rana temporaria </i>and esculentin-1 from <i>Rana esculenta</i> demonstrated concentration-dependent insulinotropic activities in rat clonal pancreatic beta cells (BRIN-BD11) and human-derived pancreatic beta cells (1.1B4). Insulinotropic activities of the esculentin-1 peptides were associated with an increase in membrane potential and intracellular calcium, whereas frenatin 2D and temporin peptides had no effect on these parameters. In BRIN-BD11 cells, frenatin 2D peptides produced a significant increase in cAMP production and its insulin-releasing activity was abolished in PKA downregulated cells. In addition to their insulinotropic activities, these peptides protected BRIN-BD11 cells against cytokine-induced apoptosis as well as stimulated proliferation of beta-cell. Frenatin 2D and its synthetic analogues [D1W] and [G7W], temporin G and esculentin (1-21)1c improved blood glucose and increased insulin concentration in lean mice. In genetically obese-diabetic mice (<i>db/db), </i>frenatin 2D, [A14K] PGLa-AM1 and [S4K] CPF-AM1 improved blood glucose, insulin sensistivity, insulin secretory responses of islets to glucose and established insulin secretagogues, lipid profile and both kidney and liver function. The gradual demise of beta cells and a decrease of circulating insulin in <i>db/db </i>mice was delayed significantly by these peptides. Also, genes involved in both insulin signalling and secretion were improved. In conclusion, this thesis highlights the potential of frog skin peptides belonging to the family of Alytidae, Hylidae, Pipidae and Ranidae for further development into therapeutic agents for type 2 diabetes.
Subjects/Keywords: Diabetes
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APA ·
Chicago ·
MLA ·
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Export
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APA (6th Edition):
Musale, V. (2019). Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes. (Doctoral Dissertation). Ulster University. Retrieved from https://ulster.pure.elsevier.com/en/studentTheses/b0439836-cc81-42c5-8bd8-c62cfa2938a0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793762
Chicago Manual of Style (16th Edition):
Musale, Vishal. “Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes.” 2019. Doctoral Dissertation, Ulster University. Accessed April 17, 2021.
https://ulster.pure.elsevier.com/en/studentTheses/b0439836-cc81-42c5-8bd8-c62cfa2938a0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793762.
MLA Handbook (7th Edition):
Musale, Vishal. “Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes.” 2019. Web. 17 Apr 2021.
Vancouver:
Musale V. Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes. [Internet] [Doctoral dissertation]. Ulster University; 2019. [cited 2021 Apr 17].
Available from: https://ulster.pure.elsevier.com/en/studentTheses/b0439836-cc81-42c5-8bd8-c62cfa2938a0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793762.
Council of Science Editors:
Musale V. Frog skin host-defence peptides and their synthetic analogues with therapeutic potential for type 2 diabetes. [Doctoral Dissertation]. Ulster University; 2019. Available from: https://ulster.pure.elsevier.com/en/studentTheses/b0439836-cc81-42c5-8bd8-c62cfa2938a0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793762
12.
Davis, Ruth Elizabeth.
Advancing nursing jurisdiction in diabetes care.
Degree: PhD, University of Glamorgan, 2012, University of South Wales
URL: http://hdl.handle.net/10265/604
► Nursing has its own unique contribution to make to diabetes care, but that impact is rarely quantified, measured or conceptualised. The thesis makes this contribution…
(more)
▼ Nursing has its own unique contribution to make to diabetes care, but that impact is rarely quantified, measured or conceptualised. The thesis makes this contribution in the form of three published research projects and proposes an adaptation to Abbott’s conceptual framework on the division of expert labour. The first research project demonstrates the value of the hospital based diabetes specialist nurse using a randomised controlled trial; the second delineates the competences of different levels of nurses in diabetes care using a nominal group technique and the third project provides a baseline of the state of nursing in relation to the initiation of insulin therapy using a survey approach. Each project is followed by a personal reflection and discussion of the implications in the light of Abbott’s framework.
Abbott’s thesis is that the development of professions is determined by a series of jurisdictional disputes rather than by a grand plan of the professions themselves. While this assertion does not always hold true in diabetes care the studies do concur with Abbott in other ways, particularly that the profession can be taken forward by taking responsibility for appropriate educational preparation, extending the boundaries of knowledge and the nursing role where appropriate. The discussion cautions against setting up professional edifices that become self-serving and stifle development, either by rigid enforcement of competences or by fossilising the nursing contribution to diabetes care. In terms of the care of the person with diabetes, nursing remains most effective within the umbrella of a multi-disciplinary team while demonstrating its own contribution. Nursing should show professionalism by continually striving for excellence, developing new knowledge and pushing role boundaries when it is in the best interests of the patient.
The original contribution to knowledge is shown in the research projects’ contribution to the evolution of diabetes nursing in the United Kingdom and the proposal that Abbott’s framework be modified to put more emphasis on the task of work to achieve optimum patient outcomes than on the jostling of professions; acknowledging the growth in multi-disciplinary team-working and rise in the power of organisations at the expense of the power of individual professions since his work was first published.
Subjects/Keywords: Diabetes; Diabetes Treatment; Diabetes Nursing
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APA ·
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APA (6th Edition):
Davis, R. E. (2012). Advancing nursing jurisdiction in diabetes care. (Doctoral Dissertation). University of South Wales. Retrieved from http://hdl.handle.net/10265/604
Chicago Manual of Style (16th Edition):
Davis, Ruth Elizabeth. “Advancing nursing jurisdiction in diabetes care.” 2012. Doctoral Dissertation, University of South Wales. Accessed April 17, 2021.
http://hdl.handle.net/10265/604.
MLA Handbook (7th Edition):
Davis, Ruth Elizabeth. “Advancing nursing jurisdiction in diabetes care.” 2012. Web. 17 Apr 2021.
Vancouver:
Davis RE. Advancing nursing jurisdiction in diabetes care. [Internet] [Doctoral dissertation]. University of South Wales; 2012. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10265/604.
Council of Science Editors:
Davis RE. Advancing nursing jurisdiction in diabetes care. [Doctoral Dissertation]. University of South Wales; 2012. Available from: http://hdl.handle.net/10265/604
13.
Davis, Ruth Elizabeth.
Advancing nursing jurisdiction in diabetes care.
Degree: PhD, 2011, University of South Wales
URL: https://pure.southwales.ac.uk/en/studentthesis/advancing-nursing-jurisdiction-in-diabetes-care(9b06e8b5-a47f-44d6-9cab-371fb532a55b).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551133
► Nursing has its own unique contribution to make to diabetes care, but that impact is rarely quantified, measured or conceptualised. The thesis makes this contribution…
(more)
▼ Nursing has its own unique contribution to make to diabetes care, but that impact is rarely quantified, measured or conceptualised. The thesis makes this contribution in the form of three published research projects and proposes an adaptation to Abbott’s conceptual framework on the division of expert labour. The first research project demonstrates the value of the hospital based diabetes specialist nurse using a randomised controlled trial; the second delineates the competences of different levels of nurses in diabetes care using a nominal group technique and the third project provides a baseline of the state of nursing in relation to the initiation of insulin therapy using a survey approach. Each project is followed by a personal reflection and discussion of the implications in the light of Abbott’s framework. Abbott’s thesis is that the development of professions is determined by a series of jurisdictional disputes rather than by a grand plan of the professions themselves. While this assertion does not always hold true in diabetes care the studies do concur with Abbott in other ways, particularly that the profession can be taken forward by taking responsibility for appropriate educational preparation, extending the boundaries of knowledge and the nursing role where appropriate. The discussion cautions against setting up professional edifices that become self-serving and stifle development, either by rigid enforcement of competences or by fossilising the nursing contribution to diabetes care. In terms of the care of the person with diabetes, nursing remains most effective within the umbrella of a multi-disciplinary team while demonstrating its own contribution. Nursing should show professionalism by continually striving for excellence, developing new knowledge and pushing role boundaries when it is in the best interests of the patient. The original contribution to knowledge is shown in the research projects’ contribution to the evolution of diabetes nursing in the United Kingdom and the proposal that Abbott’s framework be modified to put more emphasis on the task of work to achieve optimum patient outcomes than on the jostling of professions; acknowledging the growth in multi-disciplinary team-working and rise in the power of organisations at the expense of the power of individual professions since his work was first published.
Subjects/Keywords: 616.4620231; Diabetes; Diabetes treatment; Diabetes nursing
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Davis, R. E. (2011). Advancing nursing jurisdiction in diabetes care. (Doctoral Dissertation). University of South Wales. Retrieved from https://pure.southwales.ac.uk/en/studentthesis/advancing-nursing-jurisdiction-in-diabetes-care(9b06e8b5-a47f-44d6-9cab-371fb532a55b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551133
Chicago Manual of Style (16th Edition):
Davis, Ruth Elizabeth. “Advancing nursing jurisdiction in diabetes care.” 2011. Doctoral Dissertation, University of South Wales. Accessed April 17, 2021.
https://pure.southwales.ac.uk/en/studentthesis/advancing-nursing-jurisdiction-in-diabetes-care(9b06e8b5-a47f-44d6-9cab-371fb532a55b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551133.
MLA Handbook (7th Edition):
Davis, Ruth Elizabeth. “Advancing nursing jurisdiction in diabetes care.” 2011. Web. 17 Apr 2021.
Vancouver:
Davis RE. Advancing nursing jurisdiction in diabetes care. [Internet] [Doctoral dissertation]. University of South Wales; 2011. [cited 2021 Apr 17].
Available from: https://pure.southwales.ac.uk/en/studentthesis/advancing-nursing-jurisdiction-in-diabetes-care(9b06e8b5-a47f-44d6-9cab-371fb532a55b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551133.
Council of Science Editors:
Davis RE. Advancing nursing jurisdiction in diabetes care. [Doctoral Dissertation]. University of South Wales; 2011. Available from: https://pure.southwales.ac.uk/en/studentthesis/advancing-nursing-jurisdiction-in-diabetes-care(9b06e8b5-a47f-44d6-9cab-371fb532a55b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551133
14.
Lahti, Eveliina.
Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella.
Degree: 2014, Seinäjoen ammattikorkeakoulu
URL: http://www.theseus.fi/handle/10024/78917
► Opinnäytetyömme aiheena oli tyypin 2 diabeetikoiden ryhmäohjaus Kuusiokuntien alueella. Ryhmäohjausta toteutettiin Diabetes Keskustelut -ohjelman avulla, jonka on kehittänyt yhdysvaltalainen Healthy Interaction. Ohjauksessa käytettiin keskustelukarttoja, joiden…
(more)
▼ Opinnäytetyömme aiheena oli tyypin 2 diabeetikoiden ryhmäohjaus Kuusiokuntien alueella. Ryhmäohjausta toteutettiin Diabetes Keskustelut -ohjelman avulla, jonka on kehittänyt yhdysvaltalainen Healthy Interaction. Ohjauksessa käytettiin keskustelukarttoja, joiden tarkoituksena oli tukea ryhmässä käsiteltyjen asioiden mieleen jäämistä.
Opinnäytetyön tavoitteena oli selvittää, miten ryhmämuotoinen ohjaus tukee asiakasta omahoitoon. Tavoitteena oli myös, että opinnäytetyöllä saadaan lisää tietoa käytännön hoitotyöhön sekä tyypin 2 diabeteksen ohjaukseen. Opinnäytetyön tarkoituksena oli selvittää, miten tyypin 2 diabetesta sairastavat kokevat ryhmästä saamansa vertaistuen ja, miten Diabetes Keskustelut -ohjelma edistää valmiuksia omahoitoon. Tutkimustehtävät olivat: Miten Diabetes Keskustelut -ohjelma tukee tyypin 2 diabeetikkoa omahoitoon? Millaisena tyypin 2 diabetesta sairastavat kokevat Diabetes Keskustelut -ohjelmasta saamansa vertaistuen?
Opinnäytetyössä käytettiin laadullista eli kvalitatiivista tutkimusmenetelmää. Aineisto kerättiin teemahaastattelun ja avoimen kyselylomakkeen avulla haastattelemalla yhteensä kahdeksaa tyypin 2 diabetesta sairastavaa, jotka ovat osallistuneet Diabetes Keskustelut -ohjelmaan. Haastattelujen aineisto analysoitiin käyttämällä aineistolähtöistä eli induktiivista sisällönanalyysiä.
Tutkimuksessa esiin nousi vertaistuen merkitykseen liittyen myönteisinä asioina kokemusten vaihto ja ryhmästä saatu tuki. Ryhmän koolla koettiin olevan vaikutusta vertaistuen laatuun. Diabetes keskustelut -ohjelmassa haastateltavien mukaan päällimmäisiä teemoja olivat tyypin 2 diabeetikon omahoidon-ohjeet ravitsemuksessa, liikunnassa, lääkehoidossa sekä jalkojenhoidossa. Ohjauksessa käytettyjen keskustelukarttojen koettiin havainnollistavan käsiteltyjä asioita ja tukevan oppimista.
The subject of our thesis was the guidance group of people who have type 2 diabetes in Kuusiokunnat area. The group guidance was carried out with Diabetes Conservations -program which is developed by U.S. Healthy Interaction. Talk maps were used in the guidance whose purpose was to support remembering the things that were processed in the group.
The goal of the thesis was to find out how group-shaped guidance supports clients’ self-management. Another objective was for the research to gain more knowledge on practical nursing and guidance of type 2 diabetes. The thesis’s purpose was to find out how people with type 2 diabetes experience the peer support they get from the group. The research tasks were to investigate, on one hand, how Diabetes Conservations - program encourages persons with type 2 diabetes to self-management, and on the other hand, how people who have type 2 diabetes experience the peer support they get from Diabetes Conservations -program.
A qualitative research method was used in the thesis. The material was collected with the help of a theme interview and questionnaire, interviewing eight persons with type 2 diabetes who have participated in Diabtetes Conservations -program. The material from the…
Advisors/Committee Members: Seinäjoen ammattikorkeakoulu.
Subjects/Keywords: diabetes; aikuistyypin diabetes; nuoruustyypin diabetes; vertaistuki; itsehoito
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Manager
APA (6th Edition):
Lahti, E. (2014). Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella. (Thesis). Seinäjoen ammattikorkeakoulu. Retrieved from http://www.theseus.fi/handle/10024/78917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lahti, Eveliina. “Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella.” 2014. Thesis, Seinäjoen ammattikorkeakoulu. Accessed April 17, 2021.
http://www.theseus.fi/handle/10024/78917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lahti, Eveliina. “Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella.” 2014. Web. 17 Apr 2021.
Vancouver:
Lahti E. Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella. [Internet] [Thesis]. Seinäjoen ammattikorkeakoulu; 2014. [cited 2021 Apr 17].
Available from: http://www.theseus.fi/handle/10024/78917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lahti E. Diabetes Keskustelut -ohjelma : Tyypin 2 diabetesta sairastavien kokemukset ryhmämuotoisesta terveysneuvonnasta Kuusiokuntien alueella. [Thesis]. Seinäjoen ammattikorkeakoulu; 2014. Available from: http://www.theseus.fi/handle/10024/78917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Helsinki
15.
Lundgren, Virve.
Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes.
Degree: Institute of Clinical Medicine, Sisätaudit, 2013, University of Helsinki
URL: http://hdl.handle.net/10138/37943
► Evidence is emerging that Type 1 and Type 2 diabetes cluster in families. GAD autoantibodies (GADA) occur more often in families with Type 1 and…
(more)
▼ Evidence is emerging that Type 1 and Type 2 diabetes cluster in families. GAD autoantibodies (GADA) occur more often in families with Type 1 and Type 2 diabetes, are useful to predict diabetes in Type 1 diabetes studies, but their predictive value in adult relatives without diabetes is still unclear. GADA positivity is associated with a more severe insulin deficiency in Type 2 diabetes (LADA), but some patients, especially those with lower GADA levels, are more like Type 2 diabetes patients. The aim of this thesis was to learn whether a Type 1 family history (FH) has any impact on prevalence of GADA, and further, what is the impact of GADA and FH on the development of diabetes, its clinical characteristics, and the development of insulin deficiency. Subjects included in studies were; 1) Relatives (n=4976) and spouses (n=770) of diabetes patients participating in the Botnia study. Follow-up (median 8.7 years) data were available for 2764 subjects without diabetes. 2) All GADA-positive patients with Type 2 diabetes (n=213) and 648 GADA- negative patients with Type 2 diabetes participating in the Botnia study. 3) Patients with Type 2 diabetes with a family history of both Type 1 and Type 2 diabetes (Type 1 FH, n=196) or Type 2 diabetes only (Type 2 FH, n=139).. All subjects/patients participated in an oral glucose tolerance test and patients in the MIX study also underwent a glucagon-insulin intolerance test (GITT) for estimation of their insulin secretion and insulin resistance.
Three subjects developed Type 1 diabetes, and others had a non-insulin-dependent phenotype 1 year after diagnosis. BMI, age of onset, and insulin secretion and lipids associated with GADA positivity level even before the onset of diabetes and after the diagnosis. LADA patients were leaner, but surprisingly more insulin resistant according to the insulin tolerance test. A Type 1 FH was associated with higher prevalence of GADA and strength of GADA positivity but also predisposed to a more severe insulin deficiency with earlier onset not only in patients with LADA, but also in patients with Type 2 diabetes.
A family history of Type 1 diabetes was associated with GADA positivity and especially with high GADA positivity. First-degree Type 1 FH and GADA positivity predicted diabetes in adult relatives, but seroconversion to GADA was the most important risk factor. High GADA levels implied a clearly increased risk for diabetes in both the relatives and the control subjects, while low or medium-high levels implied an increased risk only for the relatives of patients with diabetes. A combination of GADA and a Type 1 FH was associated in patients with diabetes with the greatest risk for development of insulin deficiency. Most of the patients who developed a marked insulin deficiency had a Type 1 FH, which has clinical implications for screening for insulin deficiency. Further, the heterogeneity of LADA diabetes is in part explained by a Type 1 FH and GADA levels.
Diabetes on paljon monimuotoisempi sairaus, kuin mitä nykyinen jako kahteen…
Subjects/Keywords: diabetes, Lääketiede; diabetes, Lääketiede
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APA (6th Edition):
Lundgren, V. (2013). Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/37943
Chicago Manual of Style (16th Edition):
Lundgren, Virve. “Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes.” 2013. Doctoral Dissertation, University of Helsinki. Accessed April 17, 2021.
http://hdl.handle.net/10138/37943.
MLA Handbook (7th Edition):
Lundgren, Virve. “Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes.” 2013. Web. 17 Apr 2021.
Vancouver:
Lundgren V. Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes. [Internet] [Doctoral dissertation]. University of Helsinki; 2013. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10138/37943.
Council of Science Editors:
Lundgren V. Type 1 family history and GAD autoantibodies in subjects without diabetes and patients with type 2 diabetes : prevalence and association with insulin deficiency and development of diabetes. [Doctoral Dissertation]. University of Helsinki; 2013. Available from: http://hdl.handle.net/10138/37943
Stellenbosch University
16.
Ajudua, Emmanuel Enuagwuna.
Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex.
Degree: MFamMed, Interdisciplinary Health Sciences, 2015, Stellenbosch University
URL: http://hdl.handle.net/10019.1/97196
► ENGLISH ABSTRACT: Introduction: Diabetes is the most prevalent endocrinology problem encountered in primary care practice. If recent trends showing a dramatic increase in prevalence (believed…
(more)
▼ ENGLISH ABSTRACT: Introduction: Diabetes is the most prevalent endocrinology problem encountered in primary care practice. If recent trends showing a dramatic increase in prevalence (believed to be a consequence of a decline in physical activity and excessive caloric intake) continue, then the condition will soon affect nearly 20 million people in the U.S a reflection of the global trend. Effective management requires care that is thoughtful and meticulous, incorporating intensive patient education. Euglycemic control, with the level of glycosylated haemoglobin (HbA1c) kept below 7.0mmol/L, has emerged as a major treatment objective because of its association with a marked reduction in the risk for micro vascular complications. The primary physician is in the unique position to provide comprehensive care to the diabetic patient. Setting: The aim of this study is to evaluate the profile of complications arising due to diabetes mellitus among adult diabetics attending internal medicine outpatient department and family medicine/primary care outpatient department in the Dora Nginza hospital, PE hospital complex. Method: The study is a descriptive retrospective study in which names of patients were collated from clinic records of both clinics, files sought at the records department covering the period between Jan 2007 and Jan 2008 inclusive. Prevalence of statistical variables was generated using frequency tables, bar graphs, cross tabulations and chi square test. Results: Hyperglycemia was the major complication which predominantly was associated with high haemoglobin A1c (HbA1c) levels. However, some hyperglycaemic cases were also found to be associated with normal HbA1c. Complications were found to be more in type 2 diabetics. Patients with hypertension, obesity, smoking and alcohol use were observed to have a higher risk of developing diabetic complications. The findings on retinopathy in this study was inconclusive in view of the fact that patients sent for fundoscopy did not return with documented results from the sister hospital PE provincial hospital. Family Medicine outpatient department overall did better in patient care compared to the Internal Medicine outpatient department. Conclusion: The challenge for the primary care physician is to design a therapeutic program that is safe practical and acceptable to the patient. The ultimate goal of therapy is the prevention of micro vascular and macro vascular complications, consequence of diabetes that makes the condition a major risk factor for cardiovascular disease, stroke, visual impairment, renal failure, impotence, peripheral neuropathy, limb loss and ultimately death. These can be averted through appropriate education of both hospital staff, patients and their care givers. The recommendations made are based on the findings of the study.
AFRIKAANSE OPSOMMING: Nie beskikbaar.
Advisors/Committee Members: De Villiers, P. J. T., Okere, D. O., University of Stellenbosch. Faculty of Health Sciences. Dept. of Interdisciplinary Health Sciences. Family Medicine and Primary Care..
Subjects/Keywords: UCTD; Diabetes – Complications; Diabetes – Treatment
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APA (6th Edition):
Ajudua, E. E. (2015). Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/97196
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ajudua, Emmanuel Enuagwuna. “Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex.” 2015. Thesis, Stellenbosch University. Accessed April 17, 2021.
http://hdl.handle.net/10019.1/97196.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ajudua, Emmanuel Enuagwuna. “Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex.” 2015. Web. 17 Apr 2021.
Vancouver:
Ajudua EE. Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex. [Internet] [Thesis]. Stellenbosch University; 2015. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10019.1/97196.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ajudua EE. Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex. [Thesis]. Stellenbosch University; 2015. Available from: http://hdl.handle.net/10019.1/97196
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Kakusa, Mwanja.
A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia.
Degree: 2015, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/4186
► Background: Diabetes ketoacidosis (DKA) is one of the commonly encountered diabetes mellitus emergencies in hospital setups. In Zambia, there is currently no published data on…
(more)
▼ Background: Diabetes ketoacidosis (DKA) is one of the commonly encountered diabetes mellitus emergencies in hospital setups. In Zambia, there is currently no published data on DKA. This study aimed to define the clinical profile and mortality predictors of diabetic ketoacidosis at a Zambian teaching hospital.
Methods: A cross-sectional analytical study of 80 hospitalised participants with diabetes ketoacidosis at University Teaching Hospital in Lusaka, Zambia was done over a 10 month long period from October 2013 to August 2014. The data extracted included clinical presentation, precipitating factors, laboratory profile, complications and hospitalisation outcomes. Additionally, participants were dichotomised into those with coma (Glasgow Coma Scale of 8 and below) and those without coma (Glasgow Coma Scale 9 and greater). They were followed up to end of hospitalisation. Primary outcome measured was all cause in-hospital mortality. Statistical tests used were Fisher‟s Exact, Kruskal-Wallis and logistic regression.
Results: The participants were equally distributed by gender. The median age was 40 years (IQR 31-57). Treatment non-compliance was the single highest identified risk factor for development of DKA (42.5%) followed by new detection of diabetes (27.5%) and infection (22.5%). The prevalence of hypokalaemia was 15% while that of coma was 12.5%.
Comatose participants in the study were younger than those with higher Glasgow Coma Scale (30.0 vs. 42.5 years, p-value 0.005). They also had significantly lower baseline blood pressure readings [median systolic BP 105 mmHg vs. 120 mmHg (p-value 0.032) and median diastolic BP 60 mmHg vs. 77 mmHg (p-value 0.041)]. Additionally, comatose participants had a higher baseline respiratory rate compared to patients with higher GCS (28.5/min vs. 25/min p=0.031). They also had higher baseline admission random blood glucose readings compared to patients with higher coma scores (33.0mmol/L vs. 28.0mmol/L, p-value 0.012). Their baseline sodium and chloride levels were also higher [143.5 vs. 133 mmol/L, (p=0.006) and 4.0 vs. 4.2 mmol/L, (p=0.003) respectively]. The prevalences of hypokalaemia, hypernatraemia and hyperchloraemia were equally higher amongst the comatose group compared to non-comatose patients [40% vs. 11.4% (p= 0.038), 50% vs. 14.3% ( p=0.017) and 40% vs. 10% (p= 0.027) respectively]. Complications identified in decreasing order of magnitude were acute renal failure, hypoglycaemia, aspiration, adult respiratory distress syndrome and seizures. Mortality rate was 7.5%. There were factors associated with
xiv
increased risk of mortality and these were development of aspiration during DKA admission, pneumonia at baseline, development of renal failure and altered mental status. Development of renal failure was independently predictive of mortality.
Conclusion: Treatment non-compliance is the commonest risk factor for development of DKA at University Teaching Hospital, Lusaka, Zambia. The mortality rate is high compared to statistics from advanced treatment centers.…
Subjects/Keywords: Diabetes mellitus; Diabetes Ketoacidosis
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APA (6th Edition):
Kakusa, M. (2015). A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4186
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kakusa, Mwanja. “A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia.” 2015. Thesis, University of Zimbabwe. Accessed April 17, 2021.
http://dspace.unza.zm/handle/123456789/4186.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kakusa, Mwanja. “A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia.” 2015. Web. 17 Apr 2021.
Vancouver:
Kakusa M. A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2021 Apr 17].
Available from: http://dspace.unza.zm/handle/123456789/4186.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kakusa M. A study to determine the clinical profile and mortality predictors of adult patients presenting with diabetes Ketoacidosis at the University Teaching Hospital in Lusaka,Zambia. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/4186
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ghana
18.
Adade, E.E.
Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
.
Degree: 2019, University of Ghana
URL: http://ugspace.ug.edu.gh/handle/123456789/34828
► Diabetes mellitus, is a metabolic disorder caused by the inability of the beta pancreatic cells to adequately produce insulin or due to insulin resistance of…
(more)
▼ Diabetes mellitus, is a metabolic disorder caused by the inability of the beta pancreatic cells to adequately produce insulin or due to insulin resistance of cells. As a result of the increasingly high incidence of diabetes globally, the World Health Organization (WHO) has set timelines and guidelines for the reduction of the risk of mortalities and morbidities associated with non-communicable diseases including diabetes, by the year 2030. However, this agenda is hinged on the availability of affordable, safe and effective alternatives for the management and treatment of these diseases. Hence, there is a need to explore other alternatives to the conventional oral anti-hyperglycemic agents driven by factors such as patient’s preference, demand among others.
Kombucha is tea fermented by a symbiotic culture of bacteria and yeasts (SCOBY). Consumers of Kombucha have reported several anecdotal evidences of its medicinal potential. This study seeks to investigate its anti-diabetic and probiotic effect on alloxan-induced diabetic rats. It was hypothesized that Kombucha, being a complex matrix of microorganisms and nutraceuticals, would play an essential role in the management of diabetes.
Molecular characterization of the microbiome of Kombucha using shotgun metagenomics (Oxford Nanopore MINION sequencing technology) showed Brettanomyces bruxellensis CBS 2499 as the most abundant species within the microbial community accounting for about 51 % of all reads. Brettanomyces anomalus, Komagataeibacter xylinus NBRC 15237, Bacillus nealsonii AAU1, Zygosaccharomyces bailii CLIB 213, Acetobacter, Gluconobacter and over 300 other genera and species of microorganisms including archaea and viruses were also detected using a combination of REFSEQ and One Codex data bases (OXCDB). In-vivo experiment was used to evaluate the anti-diabetic property, safety and gut microbiome changes of Kombucha. Kombucha was found to perform better than the conventional antidiabetic drugs, metformin and glibenclamide in lowering the fasting blood glucose (FBG) of the diabetic rats. Daily administration of 25 mg/kg and 100 mg/kg of freeze-dried Kombucha tea demonstrated a 5 fold reduction in FBG (p<0.05) and 40% and 50% respective increases in body weight of the alloxan-induced diabetic rats compared to the diabetic control (DC). Histological analysis, shows Kombucha enhances pancreas regeneration and hence the concomitant increase in insulin secretion as demonstrated in the study. Serum lipid profiling showed 100mg/kg Kombucha treatment increases the levels of total cholesterol (16%), high density lipoproteins (HDL) (13%) and low-density lipoproteins (LDL) (10%) but conversely reduces triglyceride level (17%) compared to the DC (p>0.05).
Further analyses demonstrated that Kombucha decreases the relative organ (liver and kidney) to body weight ratio in treated animals. In addition, Kombucha was able to reduce significantly the elevated levels of liver enzymes such as Alkaline phosphatase (ALP), Alanine transaminase (ALT) and Aspartate…
Subjects/Keywords: Diabetes Mellitus;
Diabetes;
Obesity;
Kombucha
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APA (6th Edition):
Adade, E. E. (2019). Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/34828
Chicago Manual of Style (16th Edition):
Adade, E E. “Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
.” 2019. Masters Thesis, University of Ghana. Accessed April 17, 2021.
http://ugspace.ug.edu.gh/handle/123456789/34828.
MLA Handbook (7th Edition):
Adade, E E. “Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
.” 2019. Web. 17 Apr 2021.
Vancouver:
Adade EE. Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
. [Internet] [Masters thesis]. University of Ghana; 2019. [cited 2021 Apr 17].
Available from: http://ugspace.ug.edu.gh/handle/123456789/34828.
Council of Science Editors:
Adade EE. Anti-Diabetic and Probiotic Effect of Kombucha on Alloxan-Induced Diabetic Rats
. [Masters Thesis]. University of Ghana; 2019. Available from: http://ugspace.ug.edu.gh/handle/123456789/34828
University of Oxford
19.
Kellard, Joely.
Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes.
Degree: PhD, 2020, University of Oxford
URL: http://ora.ox.ac.uk/objects/uuid:4a59c2c1-c93f-4d0c-bea6-7aeb138acde2
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.813547
► In type 2 diabetes (T2D), elevated plasma glucagon concentration (hyperglucagonaemia) exacerbates hyperglycaemia due to inappropriate insulin secretion. Despite this, very little is known about why…
(more)
▼ In type 2 diabetes (T2D), elevated plasma glucagon concentration (hyperglucagonaemia) exacerbates hyperglycaemia due to inappropriate insulin secretion. Despite this, very little is known about why glucagon secreting α cells become dysfunctional. In α cells, intracellular Ca2+ ([Ca2+]i) oscillations drive glucagon secretion but much of their regulation remains obscure. Here we investigate how [Ca2+]i oscillations are regulated, and whether α cell [Ca2+]i dynamics change when mice are fed a high fat diet (to induce a T2D-like state). Mice expressing the genetically encoded calcium sensor GCaMP3 specifically in α cells were fed a control (10% calories from fat; CTL) or high fat (60% calories from fat; HFD) diet. After 12 weeks, glucose tolerance was impaired in HFD fed mice and plasma glucagon levels were elevated. Plasma glucagon was elevated in HFD mice in vivo during insulin-induced hypoglycaemia and in the perfused pancreas in situ. Glucagon secretion from HFD islets was elevated ex vivo suggesting that intra-islet (intrinsic) effects are involved. While the [Ca2+]i oscillation frequency in α cells was reduced by high (6-15 mM) glucose in both CTL and HFD islets, the frequency was higher in HFD fed mice. Following HFD, α cell [Ca2+]i oscillations and glucagon secretion were also less sensitive to inhibition by somatostatin (SST), an effect that correlated with reduced SST secretion from δ cells in mice fed the HFD. Collectively, these data indicate that altered α cell activity underlies hyperglucagonaemia in HFD. These data provide evidence that α cell dysfunction and altered intra-islet signalling manifests early in T2D. Correcting the glucagon secretion defects may provide therapeutic advantages, highlighting the potential of the α cell as a potential pharmacological target.
Subjects/Keywords: Diabetes; Type 2 diabetes; Physiology
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Manager
APA (6th Edition):
Kellard, J. (2020). Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:4a59c2c1-c93f-4d0c-bea6-7aeb138acde2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.813547
Chicago Manual of Style (16th Edition):
Kellard, Joely. “Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes.” 2020. Doctoral Dissertation, University of Oxford. Accessed April 17, 2021.
http://ora.ox.ac.uk/objects/uuid:4a59c2c1-c93f-4d0c-bea6-7aeb138acde2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.813547.
MLA Handbook (7th Edition):
Kellard, Joely. “Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes.” 2020. Web. 17 Apr 2021.
Vancouver:
Kellard J. Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes. [Internet] [Doctoral dissertation]. University of Oxford; 2020. [cited 2021 Apr 17].
Available from: http://ora.ox.ac.uk/objects/uuid:4a59c2c1-c93f-4d0c-bea6-7aeb138acde2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.813547.
Council of Science Editors:
Kellard J. Ca²⁺ᵢ and the pancreatic α cell : intrinsic regulation and dysfunction in type 2 diabetes. [Doctoral Dissertation]. University of Oxford; 2020. Available from: http://ora.ox.ac.uk/objects/uuid:4a59c2c1-c93f-4d0c-bea6-7aeb138acde2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.813547
20.
QUEIROZ, Diego Barbosa de.
Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan.
Degree: 2014, Federal University of Pernambuco
URL: https://repositorio.ufpe.br/handle/123456789/17221
► CAPES
O conceito da “programação fetal” sugere que um individuo pode ser “programado” durante as fases intra-uterina e perinatal para desenvolver doenças na vida adulta.…
(more)
▼ CAPES
O conceito da “programação fetal” sugere que um individuo pode ser “programado” durante as fases intra-uterina e perinatal para desenvolver doenças na vida adulta. A literatura mostra que o diabetes materno produz importantes alterações metabólicas na prole adulta, predispondo-os ao surgimento de doenças cardiovasculares. Este estudo analisou se a hipertensão arterial e disfunção vascular observada em ratos adultos submetidos ao diabetes materno estariam mediadas pelas ações da angiotensina II via ativação do receptor AT1 e com as alterações na inervação perivascular em preparações de artéria mesentérica. O diabetes materno foi induzido por estreptozotocina em ratas Wistar. Alterações na homeostasia da glicose, como intolerância a glicose e resistência à insulina foram observados nos ratos adultos com 12 meses de idade provenientes de mães diabéticas (O-DR) e revertidos quando tratados com losartan. Através da medida direta da PA, a PAM
dos ratos (O-DR Losartan) apresentaram níveis normotensos quando comparado aos ratos (O-DR). No grupo (O-DR losartan) foi observado um aumento no relaxamento dependente do endotélio e redução na contração à fenilefrina quando comparado aos ratos (O-DR). Para avaliar o envolvimento dos metabolitos derivados do acido araquidônico, foram utilizados inibidores da COX-1 e 2 (indometacina) ou da COX-2 (NS-398), onde ambos não alteraram o relaxamento e contratilidade, significativamente no grupo O-DR tratado com losartan. Ao analisar a inervação perivascular em artéria mesentérica superior, os ratos O-DR de 6 meses de idade apresentaram aumento da inervação adrenérgica com participação da NA e ATP e elevação da inervação nitrergica com aumento da liberação de NO neuronal. Esses resultados sugerem que o Diabetes mellitus durante a fase intrauterina e perinatal causa modificações metabólicas, cardiovasculares e na inervação perivascular em ratos adultos e que estas alterações podem ser
explicadas pela participação da ANGII e maior ativação da inervação adrenérgica e nitrérgica nestes distúrbios.
The concept of "fetal programming" suggests that an individual can be "programmed" during intrauterine and perinatal stages to develop diseases in adulthood. The literature shows that maternal diabetes cause important metabolic changes in adult offspring, predisposing them to the emergence of cardiovascular diseases. This study examined whether hypertension and vascular dysfunction observed in adult rats subjected to maternal diabetes would be mediated by the actions of angiotensin II via AT1 receptor activation and changes in perivascular innervation in mesenteric artery preparations. Maternal diabetes induced by streptozotocin in Wistar rats. Changes in glucose homeostasis, such as glucose intolerance and insulin resistance was observed in offspring diabetic rats (O-DR) and reversed when treated with losartan. Through direct measurement of BP, MAP of rats (O-DR
Losartan) showed normotensive levels compared to offspring diabetic rats (O-DR). In group…
Advisors/Committee Members: XAVIER, Fabiano Elias.
Subjects/Keywords: Diabetes; Diabetes na gravidez
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APA (6th Edition):
QUEIROZ, D. B. d. (2014). Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan. (Doctoral Dissertation). Federal University of Pernambuco. Retrieved from https://repositorio.ufpe.br/handle/123456789/17221
Chicago Manual of Style (16th Edition):
QUEIROZ, Diego Barbosa de. “Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan.” 2014. Doctoral Dissertation, Federal University of Pernambuco. Accessed April 17, 2021.
https://repositorio.ufpe.br/handle/123456789/17221.
MLA Handbook (7th Edition):
QUEIROZ, Diego Barbosa de. “Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan.” 2014. Web. 17 Apr 2021.
Vancouver:
QUEIROZ DBd. Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan. [Internet] [Doctoral dissertation]. Federal University of Pernambuco; 2014. [cited 2021 Apr 17].
Available from: https://repositorio.ufpe.br/handle/123456789/17221.
Council of Science Editors:
QUEIROZ DBd. Modificações no controle da função vascular na prole de ratos diabéticos tipo-1: Contribuição da inervação perivascular e os efeitos do tratamento com losartan. [Doctoral Dissertation]. Federal University of Pernambuco; 2014. Available from: https://repositorio.ufpe.br/handle/123456789/17221
21.
Miranda, Leonardo Garcia.
Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga.
Degree: 2013, Brazil
URL: http://repositorio.unb.br/handle/10482/15058
► Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2013.
Introdução / Objetivo: O presente estudo avaliou os…
(more)
▼ Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2013.
Introdução / Objetivo: O presente estudo avaliou os efeitos do Sistema de Infusão Contínua de Insulina (SICI) na prática clínica do controle glicêmico, principalmente em pacientes diabéticos tipo 1 previamente tratados com múltiplas doses de insulina (MDI) comparando a hemoglobina glicada (A1C) e episódios de hipoglicemia antes e após o início terapia com o SICI. Pacientes e Métodos: Oitenta diabéticos (49 feminino, 31 masculino), com idade [média ± DP] 27,9 ± 15,4 anos, duração do diabetes de 13,6 ± 9,1 anos e índice de massa corporal (IMC) de 22,6 ± 3,7 kg / m²) participaram deste estudo de coorte clínica, observacional e prospectivo. Resultados: A coorte que mostrou diminuição na A1C após transferência do tratamento anterior MDI (8,1 ± 1,4%) para o SICI (7,3 ± 0,9%, P <0,0001), teve redução de 0,8%,
favorecendo a terapia com o SICI. A coorte com diminuição (64% da coorte total) demonstrou redução na A1C (P <0,0001) de 8,73 ± 1,33% para 7,35 ± 0,99%, uma diferença de 1,4%. A média da A1C na coorte estável (9%) foi de 7,1%. A coorte com aumento (14%) teve piora da A1C de 6,87% para 7,54%. Hipoglicemia (eventos/paciente/mês) foi avaliada em 66 indivíduos antes e em uso do SICI. Na terapia com o SICI, as hipoglicemias graves diminuíram entre 61% na coorte total e 79% no grupo de A1c estável. Conclusão: A terapia com o SICI alcançou redução significativa dos episódios de hipoglicemia e melhora do controle glicêmico em curto prazo de acompanhamento e de sua implementação no Sistema Único de Saúde (SUS). Este estudo sugere que a terapia com o SICI é segura e eficaz em pacientes com diabetes e, quando bem selecionados, podem se beneficiar substancialmente do uso, razão pela qual o acesso a este não deve ser negado.
_______________________________________________________________________________________ ABSTRACT
Introduction / Objective: This study examined effects of Continuous Subcutaneous Infusion (CSII) in clinical practice on glycemic control mainly in type 1 diabetic patients previously treated with multiple daily injection (MDI) comparing the glycosylated hemoglobin (A1c) and hypoglycemic episodes before and after initiation CSII therapy. Patient and Methods: A total of 80 patients (49 female, 31 male, age [mean ± SD] 27.9±15.4 years, duration of diabetes 13.6±9.1 years and body mass index (BMI) 22.6±3.7 kg/m²) participated in this observational prospective cohort study. Results: The data were analyzed for the entire cohort and 3 subgroups (decreases, stable, or increased A1C) stratified according to a ≥0.5% change in A1C. The total cohort demonstrated a decrease in A1C comparing previous MDI (8.1±1.4%) to CSII therapy (7.3±0.9% P < 0.0001), a difference of 0.8% favoring CSII
therapy. The decreased cohort (64% of the total cohort) demonstrated a significant decrease in A1C (P < 0.0001) from 8.73±1.33% to 7.35±0.99%, a difference in A1C of…
Advisors/Committee Members: Motta, Luiz Augusto Casulari Roxo da.
Subjects/Keywords: Diabetes - insulina; Glicemia; Hipoglicemia; Diabetes
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APA (6th Edition):
Miranda, L. G. (2013). Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga. (Masters Thesis). Brazil. Retrieved from http://repositorio.unb.br/handle/10482/15058
Chicago Manual of Style (16th Edition):
Miranda, Leonardo Garcia. “Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga.” 2013. Masters Thesis, Brazil. Accessed April 17, 2021.
http://repositorio.unb.br/handle/10482/15058.
MLA Handbook (7th Edition):
Miranda, Leonardo Garcia. “Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga.” 2013. Web. 17 Apr 2021.
Vancouver:
Miranda LG. Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga. [Internet] [Masters thesis]. Brazil; 2013. [cited 2021 Apr 17].
Available from: http://repositorio.unb.br/handle/10482/15058.
Council of Science Editors:
Miranda LG. Avaliação de diabeticos após três meses de uso de sistema de infusão contínua de insulina, dispensado de forma protocolada pelo ambulatório de referência do Hospital Regional de Taguatinga. [Masters Thesis]. Brazil; 2013. Available from: http://repositorio.unb.br/handle/10482/15058
University of Zambia
22.
Ng'andu, Mary.
The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
.
Degree: 2014, University of Zambia
URL: http://hdl.handle.net/123456789/3238
► This research aimed at investigating the relationship between compliance and quality of life among adolescents with diabetes mellitus type 1 (DMT1). The study explored the…
(more)
▼ This research aimed at investigating the relationship between compliance and quality of life among adolescents with diabetes mellitus type 1 (DMT1). The study explored the impact of an information giving intervention on compliance and quality of life in adolescents with DMT1. It also explored the factors related to compliance namely units of insulin, delay in meal timings, lapse in diet, physical exercises and hypoglycaemic episodes. The study further explored the effect of compliance on the quality of life of the adolescents with type 1 diabetes mellitus. Sample:A total of 40 adolescents with diabetes mellitus type 1 were recruited at diabetes association of Zambia centre in University teaching hospital. The sample was in the age range of 16 to 19.Procedure:The baseline measures for intervention and control group was done in week 1(time 1), where the 40 adolescents answered the demographic questionnaire, quality of life scale modified for youths and the rating scale for compliance. In week 2 to week 9, the researcher was with the intervention group and had 1 meeting with them once in a week. In week 10; time 2, follow up measure (same used at time 1 with intervention and control group) was done. The researcher met both groups at the Diabetes Association of Zambia Centre DAZ in University teaching hospital UTH. The participants were asked to complete the demographic questionnaire, rating scale for compliance and the diabetes quality of life scale modified for youths. These questionnaires were completed one after the other in both baseline intervention and follow up (post assessment). Instructions were read to them before they started answering each questionnaire in a plenary setup.Results:The demographic results indicate an even distribution of participants by age in both the control and intervention groups. There was equal number of participants both in the control and intervention group. The compliance levels were tested at a significant level of 0.05 using a Mann Whitney U test, the results showed that there was a significant difference between the control and intervention group at follow up in compliance to treatment, impact of diabetes and worries about diabetes. However, satisfaction with life showed a significant difference between the control and intervention group at follow up, were the control group showed more satisfaction with life compared to the intervention group at follow up. The bivariate correlation coefficient accepted the hypothesis that there was a relationship between compliance and quality of life among adolescents with diabetes mellitus type 1 at a significant level of 0.01were r= 0.468 and p=0.002.
Subjects/Keywords: Diabetes in Children;
Diabetes Mellitus-Therapy;
Diabetes-Nursing;
Diabetes in Adolescence
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Manager
APA (6th Edition):
Ng'andu, M. (2014). The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3238
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ng'andu, Mary. “The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
.” 2014. Thesis, University of Zambia. Accessed April 17, 2021.
http://hdl.handle.net/123456789/3238.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ng'andu, Mary. “The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
.” 2014. Web. 17 Apr 2021.
Vancouver:
Ng'andu M. The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
. [Internet] [Thesis]. University of Zambia; 2014. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/123456789/3238.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ng'andu M. The relationship between compliance and quality of life among adolescents with Diabetes Mellitus Type 1
. [Thesis]. University of Zambia; 2014. Available from: http://hdl.handle.net/123456789/3238
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
23.
Banda, Lewis.
A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
.
Degree: 2012, University of Zambia
URL: http://hdl.handle.net/123456789/1298
► STUDY SETTING: The study was conducted at the University Teaching Hospital Lusaka Zambia in the diabetic clinic. OBJECTIVES: The study described common complications, their prevalence…
(more)
▼ STUDY SETTING:
The study was conducted at the University Teaching Hospital Lusaka Zambia in the diabetic clinic.
OBJECTIVES:
The study described common complications, their prevalence and factors associated with their development in diabetic mellitus patients.
DESIGN AND METHODS:
80 patients with diabetes mellitus were prospectively as well as retrospectively evaluated for complications over a period of 9 months. The evaluation included clinical and laboratory methods. The clinical methods entailed a detailed history, review of files and anthropometric measurements of weight and heights from which the body weight was expressed as body mass index (BMI). Ocular examination included the fundoscopy. A full physical examination was performed for possible diabetic complications. Laboratory methods included urinalysis, blood glucose, blood creatinine and other tests depending on the indication.
RESULTS:
This study has demonstrated that obesity is a major risk factor for the development of DM and that most of the patients attending the clinic are on diet and oral hypoglycaemic drugs. In this study only 31.3% had a family history of DM. Despite the regular attendance of the clinic by the majority of patients, complications were high and included, hypoglycaemia (19.2%), DKA (9.2%), hypertension (74.4%)), peripheral neuropathy (40%0), erectile dysfunction (58%), cataracts (38.8%), diabetic retinopathy (20%>), diabetic foot complications (13.8%)), strokes and clinical nephropathy (3.8%)) each and 2.5% had coronary artery disease. 15% of the patient had tuberculosis.
CONCLUSION:
This survey revealed that the majority of the patients are middle aged obese non-insulin dependent diabetics (NIDDs) with a female preponderance.
Attendance and compliance is generally good in this study population but monitoring and control of diabetes is poor.
Complications are a common problem in this study population. TB is also a big problem among diabetic patients. Hyperiidemia and cardiovascular complications are still a small problem.
Subjects/Keywords: Diabetes Mellitus
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APA (6th Edition):
Banda, L. (2012). A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1298
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Banda, Lewis. “A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
.” 2012. Thesis, University of Zambia. Accessed April 17, 2021.
http://hdl.handle.net/123456789/1298.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Banda, Lewis. “A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
.” 2012. Web. 17 Apr 2021.
Vancouver:
Banda L. A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
. [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/123456789/1298.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Banda L. A suvey of common complications associated with diabetes mellitus in the diabetic clinic at the University teaching hospital,Lusaka,Zambia
. [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1298
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Antu K, Antony.
Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore.
Degree: 2014, Cochin University of Science and Technology
URL: http://dyuthi.cusat.ac.in/purl/4961
► Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia with disturbances in carbohydrate, protein and lipid metabolism resulting from defects in insulin secretion, insulin…
(more)
▼ Diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia
with disturbances in carbohydrate, protein and lipid metabolism resulting from defects in
insulin secretion, insulin action or both. Currently there are 387 million people with
diabetes worldwide and is expected to affect 592 million people by 2035. Insulin
resistance in peripheral tissues and pancreatic beta cell dysfunction are the major
challenges in the pathophysiology of diabetes. Diabetic secondary complications (like
liver cirrhosis, retinopathy, microvascular and macrovascular complications) arise from
persistent hyperglycemia and dyslipidemia can be disabling or even life threatening.
Current medications are effective for control and management of hyperglycemia but
undesirable effects, inefficiency against secondary complications and high cost are still
serious issues in the present prognosis of this disorder. Hence the search for more
effective and safer therapeutic agents of natural origin has been found to be highly
demanding and attract attention in the present drug discovery research. The data
available from Ayurveda on various medicinal plants for treatment of diabetes can
efficiently yield potential new lead as antidiabetic agents. For wider acceptability and
popularity of herbal remedies available in Ayurveda scientific validation by the
elucidation of mechanism of action is very much essential. Modern biological techniques
are available now to elucidate the biochemical basis of the effectiveness of these
medicinal plants. Keeping this idea the research programme under this thesis has been
planned to evaluate the molecular mechanism responsible for the antidiabetic property of
Symplocos cochinchinensis, the main ingredient of Nishakathakadi Kashayam, a wellknown
Ayurvedic antidiabetic preparation. A general introduction of diabetes, its
pathophysiology, secondary complications and current treatment options, innovative
solutions based on phytomedicine etc has been described in Chapter 1.
The effect of Symplocos cochinchinensis (SC), on various in vitro biochemical targets
relevant to diabetes is depicted in Chapter 2 including the preparation of plant extract.
Since diabetes is a multifactorial disease, ethanolic extract of the bark of SC (SCE) and its
fractions (hexane, dichloromethane, ethyl acetate and 90 % ethanol) were evaluated by in
vitro methods against multiple targets such as control of postprandial hyperglycemia,
insulin resistance, oxidative stress, pancreatic beta cell proliferation, inhibition of protein
glycation, protein tyrosine phosphatase-1B (PTP-1B) and dipeptidyl peptidase-IV (DPPxxi
IV). Among the extracts, SCE exhibited comparatively better activity like alpha
glucosidase inhibition, insulin dependent glucose uptake (3 fold increase) in L6
myotubes, pancreatic beta cell regeneration in RIN-m5F and reduced triglyceride
accumulation in 3T3-L1 cells, protection from hyperglycemia induced generation of
reactive oxygen species in HepG2 cells with moderate antiglycation and PTP-1B
inhibition.…
Subjects/Keywords: Diabetes; Pathophysiology of diabetes; Diabetes secondary complications; Diabetes treatment options
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APA (6th Edition):
Antu K, A. (2014). Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/4961
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Antu K, Antony. “Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore.” 2014. Thesis, Cochin University of Science and Technology. Accessed April 17, 2021.
http://dyuthi.cusat.ac.in/purl/4961.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Antu K, Antony. “Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore.” 2014. Web. 17 Apr 2021.
Vancouver:
Antu K A. Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore. [Internet] [Thesis]. Cochin University of Science and Technology; 2014. [cited 2021 Apr 17].
Available from: http://dyuthi.cusat.ac.in/purl/4961.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Antu K A. Investigation on key molecular targets responsible for antidiabetic properties of Symplocos cochinchinensis (Lour.) S. Moore. [Thesis]. Cochin University of Science and Technology; 2014. Available from: http://dyuthi.cusat.ac.in/purl/4961
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hong Kong
25.
陳匡伶.
Determinants and
consequences of diabetes in Hong Kong.
Degree: 2009, University of Hong Kong
URL: http://hdl.handle.net/10722/56933
Subjects/Keywords: Diabetes.
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Manager
APA (6th Edition):
陳匡伶. (2009). Determinants and
consequences of diabetes in Hong Kong. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56933
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
陳匡伶. “Determinants and
consequences of diabetes in Hong Kong.” 2009. Thesis, University of Hong Kong. Accessed April 17, 2021.
http://hdl.handle.net/10722/56933.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
陳匡伶. “Determinants and
consequences of diabetes in Hong Kong.” 2009. Web. 17 Apr 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
陳匡伶. Determinants and
consequences of diabetes in Hong Kong. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/10722/56933.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
陳匡伶. Determinants and
consequences of diabetes in Hong Kong. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56933
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Tulane University
26.
LeBlanc, Karry.
A Mechanistic Model of Hemoglobin Glycosylation.
Degree: 2020, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:120523
► [email protected]
Abstract Glucose metabolism has become of particular importance with the epidemic of diabetes rising at an exponential rate. The current clinical standard used to…
(more)
▼ [email protected]
Abstract
Glucose metabolism has become of particular importance with the epidemic of diabetes rising at an exponential rate. The current clinical standard used to diagnose and monitor diabetes measures the level of glycation on the terminal valine of the β- subunit of hemoglobin (HbA1c).1,2 Current focus is limited to the extent of forming fructosamine, and although a stable product, its levels have been found to not always be a reliable index of mean blood glucose concentrations.3–5 Examination of some of the precursors to this fructosamine could be the key to understanding the discrepancies within the current HbA1c test, potentially removing the need for a systematic measurement of test result variability, the glycosylation gap (GGap).4 Using a valine derivative to mimic the terminal amino acid of hemoglobin, we were able to experimentally model this non-enzymatic reaction by reacting valinamide with glucose to produce a glucosylamine, followed by rearrangement to the more stable fructosamine. This kinetic model gives insight into the mechanistic variables involved in the formation of HbA1c and suggest that measurement of glucosylamine levels may provide a more reliable index of mean blood glucose levels. Gluconic acid is also suggested as a metabolic marker for diabetic diagnosis due to the relatively favorable oxidation of glucosylamine. Formation of gluconic acid, known to have increased concentrations in diabetics, could potentially be an alternative pathway in glucose metabolism.
1
Karry LeBlanc
Advisors/Committee Members: Byers, Larry (Thesis advisor), School of Science & Engineering Chemistry (Degree granting institution).
Subjects/Keywords: Diabetes; Glycosylation
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APA (6th Edition):
LeBlanc, K. (2020). A Mechanistic Model of Hemoglobin Glycosylation. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:120523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LeBlanc, Karry. “A Mechanistic Model of Hemoglobin Glycosylation.” 2020. Thesis, Tulane University. Accessed April 17, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:120523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LeBlanc, Karry. “A Mechanistic Model of Hemoglobin Glycosylation.” 2020. Web. 17 Apr 2021.
Vancouver:
LeBlanc K. A Mechanistic Model of Hemoglobin Glycosylation. [Internet] [Thesis]. Tulane University; 2020. [cited 2021 Apr 17].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:120523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LeBlanc K. A Mechanistic Model of Hemoglobin Glycosylation. [Thesis]. Tulane University; 2020. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:120523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
27.
Farnsworth, Amy Rebekah.
THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS.
Degree: MS, Nutrition, 2011, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06272011-102436/
;
► Hemoglobin A1c (HbA1c) levels are indicators for managing Diabetes Mellitus. This study investigated the effectiveness of Diabetes Mellitus education classes based on participants HbA1c…
(more)
▼ Hemoglobin A1c (HbA1c) levels are indicators for managing
Diabetes Mellitus. This study investigated the effectiveness of
Diabetes Mellitus education classes based on participants HbA1c levels. The HbA1c and body mass index (BMI) values were analyzed using t-tests to determine significant (<i>P</i> ≤ 0.05) differences between baseline (N = 46) levels compared to three months, six months, and 12 months after class participation and reported as means ± standard deviations. The study was not able to track all participants as some did not attend all follow-up sessions. Mean HbA1c levels were lower at three months (8.1% ± 2.1, <i>P</i> = 0.002, n = 31), six months (8.11% ± 2.6, <i>P</i> = 0.001, n = 39), and 12 months (8.7% ±± 2.3, <i>P</i> = 0.050, n = 29) compared to baseline (9.5% ± 2.4). The baseline BMI was 36.7kg/m
2 ± 9.7 with similar (<i>P</i> > 0.05) values after class attendance.
Advisors/Committee Members: Diane K. Tidwell (chair), Chiquita A. Briley (committee member), Michelle Lee (committee member).
Subjects/Keywords: HbA1c; Diabetes
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APA (6th Edition):
Farnsworth, A. R. (2011). THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-06272011-102436/ ;
Chicago Manual of Style (16th Edition):
Farnsworth, Amy Rebekah. “THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS.” 2011. Masters Thesis, Mississippi State University. Accessed April 17, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-06272011-102436/ ;.
MLA Handbook (7th Edition):
Farnsworth, Amy Rebekah. “THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS.” 2011. Web. 17 Apr 2021.
Vancouver:
Farnsworth AR. THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS. [Internet] [Masters thesis]. Mississippi State University; 2011. [cited 2021 Apr 17].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06272011-102436/ ;.
Council of Science Editors:
Farnsworth AR. THE EFFECTIVENESS OF DIABETES MELLITUS EDUCATION FOR MANAGING HEMOGLOBIN A1C LEVELS IN ADULTS. [Masters Thesis]. Mississippi State University; 2011. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-06272011-102436/ ;
28.
Komeilian, Zahra.
A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes.
Degree: PhD, Faculty of Nursing, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/cs4655g632
► Living with diabetes is challenging. Achieving optimal blood sugar balance involves major lifestyle choices and changes that can be difficult to sustain over time. When…
(more)
▼ Living with diabetes is challenging. Achieving optimal
blood sugar balance involves major lifestyle choices and changes
that can be difficult to sustain over time. When a woman with
diabetes immigrates to a new country with very different social and
cultural customs, religion, values, norms, and expectations,
effective diabetes self-care becomes even more complex. Despite a
growing number of Iranian immigrants in Canada, there is a paucity
of empirical research on how Iranian Canadian women integrate their
diabetes with their original and new cultural and social habits.
The purpose of this qualitative focused ethnography study was to
explore the experiences of Iranian Canadian women living with type
II diabetes. Transition Theory and Shifting Perspective Model
formed the study’s conceptual framework to explore and understand
the nature, conditions, and processes of these women’s
health-illness transitions associated with diabetes and how
immigration influenced their diabetes transitions. 15 women were
recruited using purposive and snowball sampling at a local Iranian
community center in a large Western Canadian city. Most women were
aged 42 to 48 years and were diagnosed 3–17 years prior to my
study, the majority being diagnosed with diabetes in Iran. They
arrived in Canada 3-25 years ago. Four women were fluent in English
and the rest understood English to some degree. Data collection
consisted of 21 individual semi-structured interviews conducted in
Farsi. Interviews explored their life journeys in learning to live
with diabetes and how their culture, social context, religion and
immigration experiences influenced this journey. Six participants
were interviewed twice to verify the researcher’s emerging
analysis. Data analysis occurred concurrently with data collection.
The analytic approach employed constant comparison, including open
and in vivo coding, categorizing, identifying themes and writing
memos. Verification strategies built into the inquiry process
ensured research strategies adhered to principles of inductive
qualitative inquiry and the results were trustworthy. Experiences
of having diabetes are contextualized by aspects of illness
identity, socio-cultural and religious commitments and practices
and immigration journeys for the women in my study. Iranian culture
was intertwined with Islamic beliefs that impact diabetes self-care
management directly and indirectly as women selectively chose which
cultural and social customs to retain or adopt. Each woman had a
unique transition trajectory in diabetes, but there were some
common phases: 1) “Dark days of diagnosis” started with the
reactions to diagnosis and included a search for meaning and cause;
2) “Struggling to live with diabetes” reflected each woman’s
personal journey as she learned how to integrate diabetes into
daily life and was faced with challenges and choices to attend to
diabetes or adhere to transitional cultural, social, family norms
and expectations; and 3) “Recognizing their life road with
diabetes” which included two sub themes of…
Subjects/Keywords: ethnography; diabetes
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APA ·
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MLA ·
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CSE |
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Manager
APA (6th Edition):
Komeilian, Z. (2016). A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cs4655g632
Chicago Manual of Style (16th Edition):
Komeilian, Zahra. “A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes.” 2016. Doctoral Dissertation, University of Alberta. Accessed April 17, 2021.
https://era.library.ualberta.ca/files/cs4655g632.
MLA Handbook (7th Edition):
Komeilian, Zahra. “A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes.” 2016. Web. 17 Apr 2021.
Vancouver:
Komeilian Z. A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes. [Internet] [Doctoral dissertation]. University of Alberta; 2016. [cited 2021 Apr 17].
Available from: https://era.library.ualberta.ca/files/cs4655g632.
Council of Science Editors:
Komeilian Z. A Focused Ethnography of Iranian Canadian Women’s
Experiences of Diabetes. [Doctoral Dissertation]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cs4655g632
Oregon State University
29.
Stirland, Gordon Byron.
Formulation of pharmaceuticals for the diabetic.
Degree: MS, Pharmacy, 1951, Oregon State University
URL: http://hdl.handle.net/1957/51776
Subjects/Keywords: Diabetes
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APA (6th Edition):
Stirland, G. B. (1951). Formulation of pharmaceuticals for the diabetic. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/51776
Chicago Manual of Style (16th Edition):
Stirland, Gordon Byron. “Formulation of pharmaceuticals for the diabetic.” 1951. Masters Thesis, Oregon State University. Accessed April 17, 2021.
http://hdl.handle.net/1957/51776.
MLA Handbook (7th Edition):
Stirland, Gordon Byron. “Formulation of pharmaceuticals for the diabetic.” 1951. Web. 17 Apr 2021.
Vancouver:
Stirland GB. Formulation of pharmaceuticals for the diabetic. [Internet] [Masters thesis]. Oregon State University; 1951. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/1957/51776.
Council of Science Editors:
Stirland GB. Formulation of pharmaceuticals for the diabetic. [Masters Thesis]. Oregon State University; 1951. Available from: http://hdl.handle.net/1957/51776
Oregon State University
30.
Newman, Alex.
Alloxan diabetes as a possible means of studying intermediary metabolism.
Degree: MS, Biochemistry, 1948, Oregon State University
URL: http://hdl.handle.net/1957/53513
Subjects/Keywords: Diabetes
Record Details
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Manager
APA (6th Edition):
Newman, A. (1948). Alloxan diabetes as a possible means of studying intermediary metabolism. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/53513
Chicago Manual of Style (16th Edition):
Newman, Alex. “Alloxan diabetes as a possible means of studying intermediary metabolism.” 1948. Masters Thesis, Oregon State University. Accessed April 17, 2021.
http://hdl.handle.net/1957/53513.
MLA Handbook (7th Edition):
Newman, Alex. “Alloxan diabetes as a possible means of studying intermediary metabolism.” 1948. Web. 17 Apr 2021.
Vancouver:
Newman A. Alloxan diabetes as a possible means of studying intermediary metabolism. [Internet] [Masters thesis]. Oregon State University; 1948. [cited 2021 Apr 17].
Available from: http://hdl.handle.net/1957/53513.
Council of Science Editors:
Newman A. Alloxan diabetes as a possible means of studying intermediary metabolism. [Masters Thesis]. Oregon State University; 1948. Available from: http://hdl.handle.net/1957/53513
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Open Access Theses and Dissertations
