subject:(Dextran)

Rutgers University

1. Rong, Yunhong. Probing the structure of dextran systems and their organization.

Degree: MS, Food Science, 2008, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17381

► Dextran with molecular weight 9,700 (T10) was dissolved directly in water (66%) at room temperature to form a concentration of three times its overlap concentration.… (more)

Subjects/Keywords: Dextran

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APA (6^th Edition):

Rong, Y. (2008). Probing the structure of dextran systems and their organization. (Masters Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17381

Chicago Manual of Style (16^th Edition):

Rong, Yunhong. “Probing the structure of dextran systems and their organization.” 2008. Masters Thesis, Rutgers University. Accessed June 19, 2019. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17381.

MLA Handbook (7^th Edition):

Rong, Yunhong. “Probing the structure of dextran systems and their organization.” 2008. Web. 19 Jun 2019.

Vancouver:

Rong Y. Probing the structure of dextran systems and their organization. [Internet] [Masters thesis]. Rutgers University; 2008. [cited 2019 Jun 19]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17381.

Council of Science Editors:

Rong Y. Probing the structure of dextran systems and their organization. [Masters Thesis]. Rutgers University; 2008. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17381

The Ohio State University

2. Grahame, David A. (David Alexander). The purification of dextransucrase and the study of its structural and catalytic properties.

Degree: PhD, Graduate School, 1984, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487255963554899

Subjects/Keywords: Chemistry; Dextran

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APA (6^th Edition):

Grahame, D. A. (. A. (1984). The purification of dextransucrase and the study of its structural and catalytic properties. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1487255963554899

Chicago Manual of Style (16^th Edition):

Grahame, David A (David Alexander). “The purification of dextransucrase and the study of its structural and catalytic properties.” 1984. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487255963554899.

MLA Handbook (7^th Edition):

Grahame, David A (David Alexander). “The purification of dextransucrase and the study of its structural and catalytic properties.” 1984. Web. 19 Jun 2019.

Vancouver:

Grahame DA(A. The purification of dextransucrase and the study of its structural and catalytic properties. [Internet] [Doctoral dissertation]. The Ohio State University; 1984. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487255963554899.

Council of Science Editors:

Grahame DA(A. The purification of dextransucrase and the study of its structural and catalytic properties. [Doctoral Dissertation]. The Ohio State University; 1984. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1487255963554899

The Ohio State University

3. Hamdy, Mostafa Kamal. Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander.

Degree: PhD, Graduate School, 1953, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486550192262579

Subjects/Keywords: Biology; Dextran

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APA (6^th Edition):

Hamdy, M. K. (1953). Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486550192262579

Chicago Manual of Style (16^th Edition):

Hamdy, Mostafa Kamal. “Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander.” 1953. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486550192262579.

MLA Handbook (7^th Edition):

Hamdy, Mostafa Kamal. “Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander.” 1953. Web. 19 Jun 2019.

Vancouver:

Hamdy MK. Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander. [Internet] [Doctoral dissertation]. The Ohio State University; 1953. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486550192262579.

Council of Science Editors:

Hamdy MK. Factors affecting the production of dextran having physico-chemical properties of a plasma volume expander. [Doctoral Dissertation]. The Ohio State University; 1953. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486550192262579

University of British Columbia

4. Forster, Allan Bruce Burton. The use of dextrans as particulate tracers in respiratory epithelial permeability studies .

Degree: 1981, University of British Columbia

URL: http://hdl.handle.net/2429/23141

► These experiments were designed to test the suitability of dextrans as alternate light and electron microscopic tracers to horseradish peroxidase (HRP) in studies of respiratory… (more)

▼ These experiments were designed to test the suitability of dextrans as alternate light and electron microscopic tracers to horseradish peroxidase (HRP) in studies of respiratory epithelial permeability in control and cigarette smoke-exposed guinea pigs. Nine animals were utilized initially to establish the most effective means of preserving highly water-soluble dextran while adequately maintaining airway cell ultrastructure. The perfusion-nebulization fixation and carbohydrate retention techniques developed were then used on the twenty-six guinea pigs in the permeability study. Five animals served as controls, while others were exposed to the dextran tracer, smoke from 10 cigarettes, or both. Intratracheal tracer instillations of sonicated preparations of unlabelled or either FITC- or iron-labelled dextran T10 or T40 were carried out 1/2-hour after smoke exposure. All dextrans could be visualized light-microscopically along the respiratory epithelium of airways and lung parenchyma by the Mowry-Millican technique, a modified alcoholic periodic acid-schiff (PAS) stain. As witnessed in previous HRP studies, some post-mortem tracer diffusion was seen, and no difference in dextran epithelial penetration was noted between smoked and sham-smoked animals. At the electron microscopic level, treatment of guinea pig trachea and lung with aldehyde-OsO₄-lead citrate fixative cocktail preserved the unlabelled dextran as irregular, highly electron-dense aggregates of particles along the luminal surfaces only of airways of control guinea pigs. One-half of the animals in the smoke-exposed group showed penetration of dextran between the tracheal epithelial cells. Incomplete tracer dissolution prior to instillation, as shown by negative staining of the instillates, is thought to be responsible for this inconsistency. No intrapulmonary or alveolar trans-epithelial tracer transport could be detected. FITC-dextrans presented the additional advantages of qualitative detection by fluorescence-differentiated interference contrast (DIC) microscopy and quantitative detection by spectrophotofluoro-metric means. Iron-dextrans exhibited too large a molecular size for practical use with smoke-exposed guinea pig tracheobronchial epithelium. We conclude that dextrans provide distinct advantages over HRP in terms of low price, inertness, and size versatility, as light and electron microscopic tracers.

Subjects/Keywords: Dextran; Epithelium

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APA (6^th Edition):

Forster, A. B. B. (1981). The use of dextrans as particulate tracers in respiratory epithelial permeability studies . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/23141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Forster, Allan Bruce Burton. “The use of dextrans as particulate tracers in respiratory epithelial permeability studies .” 1981. Thesis, University of British Columbia. Accessed June 19, 2019. http://hdl.handle.net/2429/23141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Forster, Allan Bruce Burton. “The use of dextrans as particulate tracers in respiratory epithelial permeability studies .” 1981. Web. 19 Jun 2019.

Vancouver:

Forster ABB. The use of dextrans as particulate tracers in respiratory epithelial permeability studies . [Internet] [Thesis]. University of British Columbia; 1981. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2429/23141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Forster ABB. The use of dextrans as particulate tracers in respiratory epithelial permeability studies . [Thesis]. University of British Columbia; 1981. Available from: http://hdl.handle.net/2429/23141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

5. Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani, Zakaria. Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter.

Degree: Engineering Sciences, 2015, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254851

► Projektet har inriktning på Galdermas produkter Deflux och Solesta, de ämnen som produkterna är uppbyggda av (dextran och hyaluronsyra) har studerats laborativt. Ändringar av… (more)

Subjects/Keywords: Dextran; Hyaluronsyra; Siktningsmetoder; Deflux; Solesta

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APA (6^th Edition):

Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani, Z. (2015). Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani, Zakaria. “Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter.” 2015. Thesis, Uppsala University. Accessed June 19, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani, Zakaria. “Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter.” 2015. Web. 19 Jun 2019.

Vancouver:

Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani Z. Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter. [Internet] [Thesis]. Uppsala University; 2015. [cited 2019 Jun 19]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aldujaili, Aya; Berndtson, Emma; Hedström, Tom; Piccolo, Sofia; Rahmani Z. Hur partikelstorleksfördelning påverkar kritiska parametrar för medicinska enheter. [Thesis]. Uppsala University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oklahoma

6. Nguyen, Hoai. Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs.

Degree: PhD, 2015, University of Oklahoma

URL: http://hdl.handle.net/11244/14597

► Cardiovascular diseases, including acute myocardial infarction, stroke, peripheral arterial diseases, and pulmonary embolism, are the most common and growing cause of morbidity and mortality in… (more)

▼ Cardiovascular diseases, including acute myocardial infarction, stroke, peripheral arterial diseases, and pulmonary embolism, are the most common and growing cause of morbidity and mortality in the United States. Early reperfusion of occluded blood vessels can be achieved by using thrombolytic therapy. However, thrombolysis is associated with its side effects, including bleeding complications and reocclusion. The hours after treatment for myocardial infarction represent a critical period when the patient is subject to reocclusion and a second coronary event. While rapid release on the order of minutes is desirable initially, an extended half-life of a thrombolytic agent functions better to address reocclusion. The overall goal of this research was the design, synthesis, characterization and testing of microspheres which i) are suitable for extension the half-life of a thrombolytic agent for prevention of reocclusion in vitro, and ii) provide a general controlled release by triggered release mechanism for cardiovascular delivery of therapeutic drugs. The first project of this thesis is to synthesize dextran acetate (DA) with various degrees of substitutions (DA1<DA2<DA3) and prepare, characterize polyethylene glycol (PEG)/DA microspheres which were combined with PEG microspheres to provide short and intermediate term release. Bovine serum albumin (BSA) was used as a model protein. PEG/DA3 microspheres exhibited the release of BSA on the scale of hours (180 min), more slowly than that of PEG microspheres. The percentage of BSA released from PEG and PEG/DA3 microspheres with time (min) was modeled mathematically [YPEG = 100(1 – e−0.12t); YPEG/DA3 = 100(1 – e−0.024t)] in order to predict cumulative delivery from mixtures in vitro over a period of hours when constrained to a target level at 30 min. The system is examined for potential application in thrombolytic therapy. The second project is to develop and characterize eudragit (Eud) microspheres which were coated with chitosan (CS) by the covalent bonding in order to meet short and longer term needs. The extension of thrombolytic activity of these microspheres in in vitro experiments was also examined. CS-Eud/SK microspheres had a lower encapsulation efficiency of streptokinase (SK), reduced activity of SK, and a much slower release of SK when compared with those of Eud/SK microspheres. Release of SK from Eud/SK microspheres obeyed first-order kinetics model [YEud/SK = 100(1 – e−0.6t)] while release of SK from CS-Eud/SK microspheres obeyed the Hixson-Crowell model [YCS-Eud/SK = 100(1 – (1 – 0.1t)3)]. Counter-intuitively, slower release leads to faster thrombolysis as a result of greater penetration of agent into the thrombus and the mechanism of distributed intraclot thrombolysis. In the in vitro lysis experiment, the presence of CS coating on the surface of Eud/SK microspheres induced a much slower release of SK up to 8 h which would seem to provide clot-lytic efficacy in prevention of second blockage up to 4 h. This study has demonstrated that longer release… Advisors/Committee Members: O'Rear, Edgar (advisor), Nollert, Matthias (committee member), Harrison, Roger (committee member), Gan, Rong (committee member), Sabatini, David (committee member).

Subjects/Keywords: Reocclusion; Thrombolysis; Microspheres; Dextran

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, H. (2015). Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/14597

Chicago Manual of Style (16^th Edition):

Nguyen, Hoai. “Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs.” 2015. Doctoral Dissertation, University of Oklahoma. Accessed June 19, 2019. http://hdl.handle.net/11244/14597.

MLA Handbook (7^th Edition):

Nguyen, Hoai. “Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs.” 2015. Web. 19 Jun 2019.

Vancouver:

Nguyen H. Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs. [Internet] [Doctoral dissertation]. University of Oklahoma; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11244/14597.

Council of Science Editors:

Nguyen H. Encapsulated thrombolytic microspheres to prevent reocclusion after thrombolysis and triggered release microspheres to deliver therapeutic drugs. [Doctoral Dissertation]. University of Oklahoma; 2015. Available from: http://hdl.handle.net/11244/14597

Hong Kong University of Science and Technology

7. Tsai, Sheung Pun LIFS. Dextran-hemoglobin as potential blood substitute.

Degree: 1997, Hong Kong University of Science and Technology

URL: https://doi.org/10.14711/thesis-b571519 ; http://repository.ust.hk/ir/bitstream/1783.1-97219/1/th_redirect.html

► Hemoglobin (Hb) has long been proposed for use as a blood substitute. In order to overcome its disadvantages of massive renal excretion and short plasma… (more)

▼ Hemoglobin (Hb) has long been proposed for use as a blood substitute. In order to overcome its disadvantages of massive renal excretion and short plasma half-life, Hb was conjugated to dextran yielding a dextran-hemoglobin conjugate (Dx-Hb). Methods to stabilize and right-shift the conjugates had been invented, and exchange transfusions with Dx-Hb in dogs and macaques performed. However, hitherto the flow properties of the conjugate have not been investigated. In this study, Dx-Hb with varying viscosities (1.98 - 2.60 cps) and effects on erythrocyte sedimentation rate (ESR) (12 - 53 mm/hr) were synthesized, and the precise relationship between ESR enhancement and the molecular size of modified Hb was delineated. It was found that red blood cell aggregation was induced by overly large glutaraldehyde-polymerized hemoglobin (Poly-Hb) or Dx-Hb molecules. On the other extreme, excessively small molecules would result in high renal excretion levels. Employing the two indices, namely ESR enhancement and renal excretion level, a molecular weight window was defined for each of Poly-Hb and Dx-Hb, within which no disturbance of ESR or renal excretion was observed. It was determined that the effective molecular size for Dx-Hb or right-shifted dextran-hemoglobin (rsDx-Hb) for this purpose is 100 kD to 350 kD. When some elevation of ESR is desired, the effective size could be upwards from 350 kD. In order to further define the clinical usefulness of the different sizes of conjugates, excretion by rabbits and exchange transfusion in dogs were performed. Dextran-hemoglobin synthesized from dextran of 10 kD (Dx(Tl0)-Hb) showed basically the same excretion rate as Dx-Hb synthesized from larger dextrans. The excretion of Dx-Hb was less than 8%, whereas for unmodified Hb it was about 40%. The hematocrit could be lowered to less than 2% with the refined rsDx-Hb, and the dogs survived essentially complete exchange transfusion. Both in vivo and in vitro methods were employed to confirm the hypothesis that Dx-Hb or rsDx-Hb could bind sufficient nitric oxide to increase vascular tone. This allows a deeper understanding of the intrinsic physiological properties of the conjugation product. Researches in defining the manufacturing parameters such as the choice of starting size of dextran and the synthetic conditions for the conjugation were performed. With the use of Dx(Tl0) and diafiltration (the retentate of 50 kD cartridge) to select the desirable size of bromodextran, optimal preparation of Dx-Hb of varying size could be obtained. The production method is also cost-effective and amenable to large scale production.

Subjects/Keywords: Hemoglobin; Dextran

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APA (6^th Edition):

Tsai, S. P. L. (1997). Dextran-hemoglobin as potential blood substitute. (Thesis). Hong Kong University of Science and Technology. Retrieved from https://doi.org/10.14711/thesis-b571519 ; http://repository.ust.hk/ir/bitstream/1783.1-97219/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tsai, Sheung Pun LIFS. “Dextran-hemoglobin as potential blood substitute.” 1997. Thesis, Hong Kong University of Science and Technology. Accessed June 19, 2019. https://doi.org/10.14711/thesis-b571519 ; http://repository.ust.hk/ir/bitstream/1783.1-97219/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tsai, Sheung Pun LIFS. “Dextran-hemoglobin as potential blood substitute.” 1997. Web. 19 Jun 2019.

Vancouver:

Tsai SPL. Dextran-hemoglobin as potential blood substitute. [Internet] [Thesis]. Hong Kong University of Science and Technology; 1997. [cited 2019 Jun 19]. Available from: https://doi.org/10.14711/thesis-b571519 ; http://repository.ust.hk/ir/bitstream/1783.1-97219/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tsai SPL. Dextran-hemoglobin as potential blood substitute. [Thesis]. Hong Kong University of Science and Technology; 1997. Available from: https://doi.org/10.14711/thesis-b571519 ; http://repository.ust.hk/ir/bitstream/1783.1-97219/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Núñez, Eutimio Gustavo Fernández. Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela.

Degree: PhD, Tecnologia Nuclear - Aplicações, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29062011-164358/ ;

►

O diagnóstico precoce de tumores e metástase constitui atualmente o elemento de maior impacto dentro das políticas de saúde públicas contra o câncer. No câncer… (more)

▼

O diagnóstico precoce de tumores e metástase constitui atualmente o elemento de maior impacto dentro das políticas de saúde públicas contra o câncer. No câncer de mama e melanoma, a técnica de biópsia de linfonodo sentinela, para o diagnostico de metástase, tem sido muito utilizada evitando a dissecção total dos nodos da região anatômica afetada, e permitindo definir com precisão o procedimento terapêutico a utilizar. O objetivo principal deste trabalho centrou-se no desenvolvimento de conjugados radiomarcados de dextran-manose para diagnóstico, utilizando o núcleo de tecnécio altamente estável, [99mTc(CO)3]+. A cisteína, ligante tridentado, foi incorporada na estrutura dos conjugados, como agente quelante do Tecnécio-99m. As condições de marcação definidas para os produtos avaliados garantiram altos valores de pureza radioquímica (>90%) e atividade específica (>59,9 MBq/nmol) assim como uma alta estabilidade in vitro. Os conjugados de dextran-cisteína-manose demonstraram uma captação superior (4 vezes maior) nos nodos linfáticos em relação aos homólogos que não possuíam manose na estrutura. O conjugado de dextran-cisteína-manose de 30 kDa radiomarcado (99mTc-DCM2) foi o traçador com melhor desempenho biológico entre os avaliados à diferentes atividades injetadas. Demonstrou-se que concentrações superiores a 1 M favorecem a retenção do produto nos nodos linfáticos. As comparações com radiofármacos já utilizados no Brasil (Dextran-500 e Fitato) para detecção de linfonodo sentinela evidenciaram a superioridade do 99mTc-DCM2.

Early diagnosis of tumors and metastasis is the current cornerstone in public health policies directed towards the fights against cancer. In breast cancer and melanoma, the sentinel lymph node biopsy has been widely used for diagnoses of metastasis. The minor impact in patient of this technique compared with total nodes dissection and the accurate definition of therapeutic strategies have powered its spreading. The aim of this work was the development of radiolabeled dextran-mannose conjugates for diagnosis using the stable technetium core [99mTc(CO)3]+. Cysteine, a trident ligand, was attached to the conjugates backbone, as a chelate for 99mTc labeling. Radiolabeling conditions established for all products considered in this study showed high radiochemical purities (> 90%) and specific activities (>59,9 MBq/nmol) as well and high stability obtained through in vitro tests. The lymphatic node uptake increased significantly (4-folds) when mannose units were added to the conjugates compared with those without this monosaccharide. The radiolabeled cysteine-mannose-dextran conjugate with 30 kDa (99mTc-DCM2) showed the best performance at different injected activities among the studied tracers. Concentrations of this radiocomplex higher than 1 M demonstrated an improvement of lymph node uptakes. Comparisons of 99mTc-DCM2 performance with commercial radiopharmaceuticals in Brazil market for lymph node detection showed its upper profile.

Advisors/Committee Members: Faintuch, Bluma Linkowski.

Subjects/Keywords: cancer; câncer; dextran; dextran; linfonodo sentinela; radiofármaco; sentinel lymph; tecnécio-99m

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APA (6^th Edition):

Núñez, E. G. F. (2011). Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29062011-164358/ ;

Chicago Manual of Style (16^th Edition):

Núñez, Eutimio Gustavo Fernández. “Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela.” 2011. Doctoral Dissertation, University of São Paulo. Accessed June 19, 2019. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29062011-164358/ ;.

MLA Handbook (7^th Edition):

Núñez, Eutimio Gustavo Fernández. “Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela.” 2011. Web. 19 Jun 2019.

Vancouver:

Núñez EGF. Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2019 Jun 19]. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29062011-164358/ ;.

Council of Science Editors:

Núñez EGF. Desenvolvimento de conjugados de dextran manose radiomarcados para detecção de linfonodo sentinela. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29062011-164358/ ;

The Ohio State University

9. Haines, Willis Egbert. A study of the purification, properties, and mechanism of action of the enzyme dextransucrase.

Degree: PhD, Graduate School, 1957, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394933905883

Subjects/Keywords: Chemistry; Dextran; Sugar

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APA (6^th Edition):

Haines, W. E. (1957). A study of the purification, properties, and mechanism of action of the enzyme dextransucrase. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394933905883

Chicago Manual of Style (16^th Edition):

Haines, Willis Egbert. “A study of the purification, properties, and mechanism of action of the enzyme dextransucrase.” 1957. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394933905883.

MLA Handbook (7^th Edition):

Haines, Willis Egbert. “A study of the purification, properties, and mechanism of action of the enzyme dextransucrase.” 1957. Web. 19 Jun 2019.

Vancouver:

Haines WE. A study of the purification, properties, and mechanism of action of the enzyme dextransucrase. [Internet] [Doctoral dissertation]. The Ohio State University; 1957. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394933905883.

Council of Science Editors:

Haines WE. A study of the purification, properties, and mechanism of action of the enzyme dextransucrase. [Doctoral Dissertation]. The Ohio State University; 1957. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394933905883

The Ohio State University

10. Spendlove, John Clifton. A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides.

Degree: PhD, Graduate School, 1953, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486467544555468

Subjects/Keywords: Biology; Dextran; Leuconostoc

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APA (6^th Edition):

Spendlove, J. C. (1953). A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486467544555468

Chicago Manual of Style (16^th Edition):

Spendlove, John Clifton. “A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides.” 1953. Doctoral Dissertation, The Ohio State University. Accessed June 19, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486467544555468.

MLA Handbook (7^th Edition):

Spendlove, John Clifton. “A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides.” 1953. Web. 19 Jun 2019.

Vancouver:

Spendlove JC. A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides. [Internet] [Doctoral dissertation]. The Ohio State University; 1953. [cited 2019 Jun 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486467544555468.

Council of Science Editors:

Spendlove JC. A study of some cultural factors upon yield and character of the dextran produced by Leuconostoc mesentroides. [Doctoral Dissertation]. The Ohio State University; 1953. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486467544555468

University of Helsinki

11. Wang, Yu. In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase.

Degree: Department of Food and Environmental Sciences; Helsingfors universitet, Agrikultur- och forstvetenskapliga fakulteten, Institutionen för livsmedels- och miljövetenskaper, 2017, University of Helsinki

URL: http://hdl.handle.net/10138/222931

► Dextrans are polysaccharides and mainly produced from lactic acid bacteria, which have great values in industrial applications. Dextrans with different molar mass and branches have… (more)

▼ Dextrans are polysaccharides and mainly produced from lactic acid bacteria, which have great values in industrial applications. Dextrans with different molar mass and branches have different applications. In this thesis, the effects of different reaction factors on the molar mass and composites of dextrans had been studied. Weissella confusa VTT E-90392 dextransucrase was used to synthesize dextran with sucrose as substrates. The effects of sucrose concentration, enzyme concentration, reaction time, temperature and pH on dextran macromolecular properties were detected. Sucrose concentration, enzyme concentration and reaction time were selected as the most influential factors for the subsequent response surface modeling to analyze how they affect dextran properties, according to experimental design. 18 reaction conditions were conducted and the product mixtures containing dextran were analyzed by HPSEC. The effects of the three reaction factors on dextran production were also studied. The predictive contour plot showed that dextran conversion was positively proportional to the enzyme concentration and increased in the early stage, but decreased in the late stage. In the preliminary study of the effects of various factors on dextran profile, two or three main dextran size populations eluting at different volumes were found in HPSEC analysis. The 1st dextran size population (eluted around 10.5 ml) had the highest Mw ranging from 7 × 107 to 2 × 108 g/mol. The 2nd dextran size population (eluted at around 12.5 ml) had Mw ranging from 2 × 107 to 4×107 g/mol. Besides, there seemed to be a 3rd dextran size populations (eluted at 16.2 ml to 17.5 ml) and the Mw was within the widest range (5 × 106 g/mol to 1.3 × 107 g/mol).We kept the samples' 4 factors constant and one factor changed and compared the effect of each factor. Under conditions: low sucrose, dextransucrase concentration, low temperature, low pH or short reaction time, the amount of the 2nd dextran size population was in equal or higher amount than the 1st one and 3rd one hardly appeared. On the contrary, the 1st size population became predominant over 2nd one, and the 3rd one started to form. In the modeling experiments, the overall effects of reaction time, sucrose concentration and enzyme concentration on the molar mass and amounts of different dextran size populations were studied. In our study, as the sucrose and enzyme concentration increased, the 2nd dextran size population decreased. The amount of 3rd one was positively proportional to the sucrose and enzyme concentrations. At the early stage of reaction, the amount of 3rd one was positively proportional to the reaction time, but the amount of 3rd one was negatively proportional to the reaction time. We hypothesize that as the reaction proceeds, 2nd dextran size population can be elongated into the 1st population. It was not clear whether the 2nd dextran size population could combine with themselves to form 1st one (internal insertion) or the 2nd one could only be inserted with D-glucosyl units one by one…

Subjects/Keywords: Weissella confusa; dextran; SEC (Size-Exclusion Chromatography ); dextran size population; Elintarvikekemia; Food Chemistry; Livsmedelskemi; Weissella confusa; dextran; SEC (Size-Exclusion Chromatography ); dextran size population

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APA (6^th Edition):

Wang, Y. (2017). In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/222931

Chicago Manual of Style (16^th Edition):

Wang, Yu. “In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase.” 2017. Masters Thesis, University of Helsinki. Accessed June 19, 2019. http://hdl.handle.net/10138/222931.

MLA Handbook (7^th Edition):

Wang, Yu. “In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase.” 2017. Web. 19 Jun 2019.

Vancouver:

Wang Y. In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase. [Internet] [Masters thesis]. University of Helsinki; 2017. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10138/222931.

Council of Science Editors:

Wang Y. In vitro synthesis and macromolecular analysis of dextrans from Weissella confusa dextransucrase. [Masters Thesis]. University of Helsinki; 2017. Available from: http://hdl.handle.net/10138/222931

Louisiana State University

12. Kim, Duwoon. The production of a dextran binding antibody by phage display library and its applications to sugar processing.

Degree: PhD, 2003, Louisiana State University

URL: etd-03152004-113133 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2810

► A phage collection (M1114), which is a mixture of two collections, M710-3R and Silica 426 each derived from a human synthetic phage antibody library (Fab… (more)

▼ A phage collection (M1114), which is a mixture of two collections, M710-3R and Silica 426 each derived from a human synthetic phage antibody library (Fab 2lox), was used further enriched for dextran binding using enzyme-linked immunosorbent assays (ELISA) screening. The effects of dextran concentration on phage binding affinity were tested using indirect sandwich ELISA on phage collections, M1114-m74 and AE-M1114-m74-2R. Most of the phage bound to dextran (T2000) coated on a sandwich ELISA. The combination of ELISA screening and a sephadex columns enriched dextran binding 7 fold over enrichment by a single ELISA screen. Phage collection (M1114-m74) produced by combination screening showed the greatest binding on ELISA. The color intensity produced by phage collection (AE-M1114-m74-2R) obtained after the 2nd round of selection was 3.5 fold higher than that of phage collections, AE-M1114-m74-1R after the 1st round. Dextran binding by phage collection (AE-M1114-m74-2R) was illustrated using image analysis of transmission electron micrographs. Sephadex bead agarose electrophoresis (SBAE) screening produced phage collections (AE-M1114-m74-1R and 2R) which were used in a paper-dip assay. A dip stick assay using a protein blocked paper with adsorbed high molecular size dextran (T10,000, 107) produced the most color (59 ±5) using anti-dextran phage enzyme linked assays. Low molecular size dextran (T40, 4x104) produced significantly lower color (15 ±1). Phage collection (AE-M1114-m74-2R) was tested for specificity against dextran (T2000), corn starch, sucrose, dextrose, and chitin. Dextran produced up to 18 fold the normalized intensity of the other carbohydrates. The presence of Fab inserts in the phage collections was confirmed using PCR, and the presence of the same insert in the host E.coli was checked using a â-galactosidase linked assay. DNA sequencing of phage collection (AE-M1114-m74-2R) confirmed that human origin antibody was present. The PCR products of ë, ê light chains and heavy chain from phage collection (AE-M1114-m74-2R) were approximately 420 bp, 550 bp and 600 bp. This research used various selection methods to isolate anti-dextran phages from a library. These were used to develop a paper-dip stick method for dextran detection used for routine screening of sugar juices.

Subjects/Keywords: antibody; dextran; phage

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APA (6^th Edition):

Kim, D. (2003). The production of a dextran binding antibody by phage display library and its applications to sugar processing. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-03152004-113133 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2810

Chicago Manual of Style (16^th Edition):

Kim, Duwoon. “The production of a dextran binding antibody by phage display library and its applications to sugar processing.” 2003. Doctoral Dissertation, Louisiana State University. Accessed June 19, 2019. etd-03152004-113133 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2810.

MLA Handbook (7^th Edition):

Kim, Duwoon. “The production of a dextran binding antibody by phage display library and its applications to sugar processing.” 2003. Web. 19 Jun 2019.

Vancouver:

Kim D. The production of a dextran binding antibody by phage display library and its applications to sugar processing. [Internet] [Doctoral dissertation]. Louisiana State University; 2003. [cited 2019 Jun 19]. Available from: etd-03152004-113133 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2810.

Council of Science Editors:

Kim D. The production of a dextran binding antibody by phage display library and its applications to sugar processing. [Doctoral Dissertation]. Louisiana State University; 2003. Available from: etd-03152004-113133 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2810

University of Toronto

13. Silva, Andre Paes Batista da. Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis.

Degree: 2009, University of Toronto

URL: http://hdl.handle.net/1807/19071

►

Osteopontin (OPN) is a matricellular cytokine found in most tissues and body fluids. It is involved in a variety of cell processes by binding to… (more)

▼

Osteopontin (OPN) is a matricellular cytokine found in most tissues and body fluids. It is involved in a variety of cell processes by binding to integrins and CD44 receptors, and it modulates immune responses. To investigate the functions of OPN during colitis the DSS acute colitis model in OPN-/- and WT control mice was utilized. OPN-/- mice were more susceptible to DSS-induced colitis than the DSS-treated WT control mice. The increased susceptibility of the OPN-/- mice was characterized by greater intestinal crypt destruction; high myeloperoxidase activity of infiltrating neutrophils; lack of differentiation of inflammatory cells such as lymphocytes subsets (CD4+, CD8+) and macrophages (F4/80); reduced production of certain cytokines, especially TNF-alpha; and non-programmed cell death of enterocytes. It is postulated that the hyperactivity of neutrophils may explain the increased tissue destruction during experimental colitis in the absence of OPN. Analysis of OPN’s impact on neutrophil function showed that while OPN may be important for the recruitment and migration of neutrophils, the expression of OPN by neutrophils is not required for manifestation of their destructive capabilities. This would suggest that OPN administration may protect the intestines from the adverse effects of colitis. Exogenous bovine milk OPN (20 μg/ml), administered for 8 days dissolved in the drinking water, ameliorated DSS-induced colitis. It diminished signs of disease, with a greater impact in the WT than the OPN-/- mice. It reduced the levels of neutrophils, macrophages, and pro-inflammatory mediators in the colon tissue. Recombinant OPN failed to reproduce the beneficial effects of milk OPN, which suggests that post-translational modifications of OPN are crucial to ameliorate experimental colitis. Collectively, these studies demonstrate that OPN has a protective effect during experimental colitis and that the oral administration of bovine milk OPN (20 μg/ml) ameliorates acute DSS-induced colitis. The results of this study also imply that the protective effect probably depends on a post-translationally modified form of OPN, and may require intracellular-OPN as a cofactor for significant attenuation of colitis. Future research could concentrate on more detailed investigation of these latter findings to determine OPN’s mechanism of action.

PhD

Advisors/Committee Members: Ellen, Richard P., Dentistry.

Subjects/Keywords: Osteopontin; Colitis; Dextran Sulphate Sodium; 0571

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APA (6^th Edition):

Silva, A. P. B. d. (2009). Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/19071

Chicago Manual of Style (16^th Edition):

Silva, Andre Paes Batista da. “Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis.” 2009. Doctoral Dissertation, University of Toronto. Accessed June 19, 2019. http://hdl.handle.net/1807/19071.

MLA Handbook (7^th Edition):

Silva, Andre Paes Batista da. “Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis.” 2009. Web. 19 Jun 2019.

Vancouver:

Silva APBd. Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis. [Internet] [Doctoral dissertation]. University of Toronto; 2009. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1807/19071.

Council of Science Editors:

Silva APBd. Role of Osteopntin during Dextran Sulphate Sodium-induced Colitis. [Doctoral Dissertation]. University of Toronto; 2009. Available from: http://hdl.handle.net/1807/19071

IUPUI

14. Peuler, Kevin. Modular Nanoparticles for Selective Cell Targeting.

Degree: 2019, IUPUI

URL: http://hdl.handle.net/1805/18947

►

Indiana University-Purdue University Indianapolis (IUPUI)

Nanoparticles (NPs) are an emerging technology in biomedical engineering with opportunities in diagnostics, imaging, and drug delivery. NPs can be… (more)

Subjects/Keywords: Nanoparticle; Modular; Tetrazine; Macrophage; Heparin; Dextran Sulfate

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APA (6^th Edition):

Peuler, K. (2019). Modular Nanoparticles for Selective Cell Targeting. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/18947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peuler, Kevin. “Modular Nanoparticles for Selective Cell Targeting.” 2019. Thesis, IUPUI. Accessed June 19, 2019. http://hdl.handle.net/1805/18947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peuler, Kevin. “Modular Nanoparticles for Selective Cell Targeting.” 2019. Web. 19 Jun 2019.

Vancouver:

Peuler K. Modular Nanoparticles for Selective Cell Targeting. [Internet] [Thesis]. IUPUI; 2019. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1805/18947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peuler K. Modular Nanoparticles for Selective Cell Targeting. [Thesis]. IUPUI; 2019. Available from: http://hdl.handle.net/1805/18947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Chindawong, Chakkresit. Drying-induced structure formation in polymer films.

Degree: 2015, Technische Universität Dortmund

URL: https://doi.org/10.21268/20150507-083132 ; https://nbn-resolving.org/urn:nbn:de:gbv:104-1121769 ; https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00000111 ; https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/Document_derivate_00000161/Db112176.pdf

►

The thesis focusses on mechanisms of structure formation in drying polymer films. Most thoroughly investigated were structures, where irradiation with light created the pattern. Light… (more)

▼

The thesis focusses on mechanisms of structure formation in drying polymer films. Most thoroughly investigated were structures, where irradiation with light created the pattern. Light was always converted to a source of heat, for instance by adding a dye to the material. The dye’s absorption amounts to a localized heat source. Sine the rate of evaporation is high at the irradiated spot, there is a flow of liquid towards the irradiated spot. In consequence, a “Mexican hat” develops. The phenomenon is related to what is called “evaporative lithography” in the literature. Novel to this work is the combined action of solvent flow and buckling. Buckling leads to a characteristic pattern, which is a small peak on top of a wider pedestal. Importantly, the buckling-induced features are narrower than the features induced by flow. Buckling was only found when employing dextran. Presumably, buckling is the consequence of an elastic skin. For reasons which are not understood to date, the minimum feature size obtainable with the flow mechanism only is limited to about 300 μm. The size of the laser spot is a few tens of microns. Starting from this experience other means of localized heating were explored, as well. Films were dried films on a polyester sheet with printed black lines onto the back. When drying a polystyrene film deposited on this kind of substrate under an IR-lamp, the black line absorbed heat. The films after drying showed elevations at the position of the black lines. We showed that the amplitude of the surface features depends on several parameters such as the initial thickness of the film, the molecular weight of polystyrene and the pitch size, where increasing the pitch size leads to increasing of amplitude of surface features. Motivated by the need to create patterned structures during drying, we investigated the properties of cellulose nanocrystals (CNC). CNC does have an impact on structure formation. When cellulose nanocrystals are dispersed in water, they form a stable suspension. Depending on concentration, there is a phase separation, where the phase with lower density is isotropic, while the other phase forms a chiral nematic liquid crystal. Upon drying, CNC suspensions form fingerprint-like textures. We reported the use of a CNC/latex blend as an ink for security printing. The inks is recognized as being special in diffuse reflection, if polarizers are inserted between the light source and the paper and, also, between the paper and the observer. Such devices are easily realized; their application is trivial. Ink made of CNC appears peculiar because it scrambles the polarization from the background without being a strong scatterer, itself. Application requires a dark background. Applied to black paper, the contrast strongly depends on whether the printed area is viewed with polarizers being parallel or with crossed polarizers.

Die Dissertation befasst sich mit verschiedenen Mechanismen der Strukturbildung bei trocknenden Polymerfilmen. In der Regel wurde Licht als der…

Advisors/Committee Members: Johannsmann, Diethelm.

Subjects/Keywords: ddc:540; film formation; evaporative lithography; dextran

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APA (6^th Edition):

Chindawong, C. (2015). Drying-induced structure formation in polymer films. (Thesis). Technische Universität Dortmund. Retrieved from https://doi.org/10.21268/20150507-083132 ; https://nbn-resolving.org/urn:nbn:de:gbv:104-1121769 ; https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00000111 ; https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/Document_derivate_00000161/Db112176.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chindawong, Chakkresit. “Drying-induced structure formation in polymer films.” 2015. Thesis, Technische Universität Dortmund. Accessed June 19, 2019. https://doi.org/10.21268/20150507-083132 ; https://nbn-resolving.org/urn:nbn:de:gbv:104-1121769 ; https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00000111 ; https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/Document_derivate_00000161/Db112176.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chindawong, Chakkresit. “Drying-induced structure formation in polymer films.” 2015. Web. 19 Jun 2019.

Vancouver:

Chindawong C. Drying-induced structure formation in polymer films. [Internet] [Thesis]. Technische Universität Dortmund; 2015. [cited 2019 Jun 19]. Available from: https://doi.org/10.21268/20150507-083132 ; https://nbn-resolving.org/urn:nbn:de:gbv:104-1121769 ; https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00000111 ; https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/Document_derivate_00000161/Db112176.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chindawong C. Drying-induced structure formation in polymer films. [Thesis]. Technische Universität Dortmund; 2015. Available from: https://doi.org/10.21268/20150507-083132 ; https://nbn-resolving.org/urn:nbn:de:gbv:104-1121769 ; https://dokumente.ub.tu-clausthal.de/receive/clausthal_mods_00000111 ; https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/Document_derivate_00000161/Db112176.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

16. Howard, Angela Marie. Basement Membrane Homeostasis and Repair.

Degree: PhD, Cell and Developmental Biology, 2019, Vanderbilt University

URL: http://etd.library.vanderbilt.edu/available/etd-03222019-152412/ ;

► The basement membrane is a sheet-like extracellular matrix that wraps around muscle fibers and underlies epithelia. Although the basement membrane is often considered to be… (more)

Subjects/Keywords: Basement Membrane; Dextran Sodium Sulfate; Drosophila

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APA (6^th Edition):

Howard, A. M. (2019). Basement Membrane Homeostasis and Repair. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03222019-152412/ ;

Chicago Manual of Style (16^th Edition):

Howard, Angela Marie. “Basement Membrane Homeostasis and Repair.” 2019. Doctoral Dissertation, Vanderbilt University. Accessed June 19, 2019. http://etd.library.vanderbilt.edu/available/etd-03222019-152412/ ;.

MLA Handbook (7^th Edition):

Howard, Angela Marie. “Basement Membrane Homeostasis and Repair.” 2019. Web. 19 Jun 2019.

Vancouver:

Howard AM. Basement Membrane Homeostasis and Repair. [Internet] [Doctoral dissertation]. Vanderbilt University; 2019. [cited 2019 Jun 19]. Available from: http://etd.library.vanderbilt.edu/available/etd-03222019-152412/ ;.

Council of Science Editors:

Howard AM. Basement Membrane Homeostasis and Repair. [Doctoral Dissertation]. Vanderbilt University; 2019. Available from: http://etd.library.vanderbilt.edu/available/etd-03222019-152412/ ;

Brno University of Technology

17. Šméralová, Ester. Hydratace biopolymerů .

Degree: 2017, Brno University of Technology

URL: http://hdl.handle.net/11012/66351

► Tato bakalářská práce se zabývá studiem hydratace vybraných biopolymerů – huminových kyselin, chitosanu, kyseliny hyaluronové (nízkomolekulární a vysokomolekulární) a dextranu. K určení obsahu původní vlhkosti… (more)

Subjects/Keywords: Biopolymery; huminové kyseliny; chitosan; kyselina hyaluronová; dextran; hydratace; Biopolymers; humic acid; chitosan; hyaluronic acid; dextran; hydration

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APA (6^th Edition):

Šméralová, E. (2017). Hydratace biopolymerů . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/66351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Šméralová, Ester. “Hydratace biopolymerů .” 2017. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/66351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Šméralová, Ester. “Hydratace biopolymerů .” 2017. Web. 19 Jun 2019.

Vancouver:

Šméralová E. Hydratace biopolymerů . [Internet] [Thesis]. Brno University of Technology; 2017. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/66351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Šméralová E. Hydratace biopolymerů . [Thesis]. Brno University of Technology; 2017. Available from: http://hdl.handle.net/11012/66351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

18. Vyroubal, David. Transportní vlastnosti hydrogelových systémů na bázi dextranu .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/81434

► Tato bakalářská práce se zabývá studiem transportních vlastností hydrogelových systému na bázi dextranu. Cílem práce je prozkoumat jejich schopnost absorbovat a uvolňovat navázanou látku. Jako… (more)

Subjects/Keywords: dextran; dodecylsíran sodný; SDS; nilská červeň; hydrogel; uvolňování; spektrofotometrie; dextran; sodium dodecyl sulfate; SDS; nile red; hydrogel; releasing; spectrophotometry

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APA (6^th Edition):

Vyroubal, D. (2018). Transportní vlastnosti hydrogelových systémů na bázi dextranu . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/81434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vyroubal, David. “Transportní vlastnosti hydrogelových systémů na bázi dextranu .” 2018. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/81434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vyroubal, David. “Transportní vlastnosti hydrogelových systémů na bázi dextranu .” 2018. Web. 19 Jun 2019.

Vancouver:

Vyroubal D. Transportní vlastnosti hydrogelových systémů na bázi dextranu . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/81434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vyroubal D. Transportní vlastnosti hydrogelových systémů na bázi dextranu . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/81434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

19. Kadlec, Martin. Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/82209

► Tato bakalářská práce se zabývá studiem principu „time-temperature superposition“ a jeho možnou aplikovatelností na hydrogely. Na základě literární rešerše byl jako vhodný materiál pro optimalizaci… (more)

▼ Tato bakalářská práce se zabývá studiem principu „time-temperature superposition“ a jeho možnou aplikovatelností na hydrogely. Na základě literární rešerše byl jako vhodný materiál pro optimalizaci tohoto principu vybrán včelí med z důvodu své jednoduché viskoelastické povahy (newtonovská kapalina). Poznatky získané během optimalizace byly následně využity při studiu reálných hydrogelových materiálů, konkrétně byl vybrán agarózový gel jako zástupce termoreverzibilních hydrogelů, dále pak hyaluronanový a dextranový gel jako zástupci hydrogelů vzniklých interakcí polyelektrolytu s opačně nabitým tenzidem. Aplikací principu „time-temperature superposition“ bylo dosaženo značného zvětšení rozsahu sledované frekvence oscilace u všech vybraných vzorků, což vedlo k zisku informací o paměťovém a ztrátovém respektive komplexním modulu, kterých by nebylo možno dosáhnout pomocí klasického oscilačního testu. Ačkoliv byly vytvořeny generalizované křivky pro všechny zkoumané vzorky, pouze u hydrogelů vzniklých interakcí polyelektrolytu s opačně nabitým tenzidem bylo možno vytvořit zvlášť křivku pro paměťový respektive ztrátový modul. Z tohoto důvodu se jako vhodnější materiály pro aplikaci principu „time-temperature superposition“ jeví právě tato skupina hydrogelů.; This bachelor thesis provides a study of the “time-temperature superposition” principle and its applicability to hydrogels. According to current research, honey was chosen due to its simple viscoelastic properties (Newtonian liquid) as a suitable material for optimalization procedure. The knowledge obtained during optimization was further applied to real hydrogel materials, namely the agarose gel was selected as an example of thermoreversible hydrogel, as well as the hyaluronan and dextran gels as examples of hydrogels formed by the interaction of the polyelectrolyte with the opposite charged surfactant. By using the “time-temperature superposition” principle, a considerable increase in the range of the observed oscillation frequencies was achieved for all chosen samples, which led to gain of information about storage and loss or complex modulus, which could not be achieved by classical oscillatory test. Although master curves were generated for all the samples examined, curves for storage and loss modulus could be created separately only for hydrogels formed by the interaction of the polyelectrolyte with the opposite charged surfactant. For this reason, this group of hydrogels appears to be more suitable materials for the application of the “time-temperature superposition” principle. Advisors/Committee Members: Smilek, Jiří (advisor).

Subjects/Keywords: Reologie; princip „time-temperature superposition“; agaróza; hyaluronan; dextran; hydrogely.; Rheology; “time-temperature superposition” principle; agarose; hyaluronan; dextran; hydrogels.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kadlec, M. (2018). Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/82209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kadlec, Martin. “Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů .” 2018. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/82209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kadlec, Martin. “Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů .” 2018. Web. 19 Jun 2019.

Vancouver:

Kadlec M. Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/82209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kadlec M. Aplikace principu "time-temperature superposition" při studiu reologických vlastností polymerních materiálů . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/82209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Delattre, Cécilia. Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application.

Degree: Docteur es, Sciences de l'ingénieur mention génie biologique et médical, 2015, Sorbonne Paris Cité

URL: http://www.theses.fr/2015USPCD061

►

L’objectif de ce travail est d’évaluer la biocompatibilité d’un copolymère de Dextrane- Polybutylmethacrylate utilisé comme revêtement de stent métallique en Cobalt-Chrome. L’étude s’est déroulée en… (more)

▼

L’objectif de ce travail est d’évaluer la biocompatibilité d’un copolymère de Dextrane- Polybutylmethacrylate utilisé comme revêtement de stent métallique en Cobalt-Chrome. L’étude s’est déroulée en trois phase : 1/La production du polymère et la caractérisation physico-chimique, 2/L’évaluation in vitro et 3/L’évaluation in vivo dans plusieurs modèles. Dans un premier temps deux copolymères de concentrations distinctes ont été synthétisés et mis en forme pour les différentes expériences. Leur caractérisation par FTIR, mesure d’angle de contact et une première implantation in vivo évaluant la réaction à corps étranger a permis d’ensélectionner un : le Dex-PBMA. Aucune réaction inflammatoire chronique n’a été observée. Desépreuves dynamiques et une observation des stents recouverts au MEB ont permis de confirmer la présence et la tenue du film de Dex-PBMA sur les stents. Des tests in vitro ont montré une faible d’adhésion bactérienne et plaquettaire ainsi qu’une thrombogénicité modérée. Un dispositif sous flux ex vivo et l’utilisation d’une molécule modèle - le Tacrolimus – ont montré la faisabilité d’utiliser le Dex-PBMA comme plateforme de libération de substances. In vitro, l’adhésion et la prolifération des progéniteurs endothéliaux ainsi que des cellules souches mésenchymateuses étaient faibles mais aucun effet toxique n’a été noté. Finalement les stents recouverts de Dex-PBMA ont été implantés in vivo dans un modèle d’aorte saine de rat puis dans un modèle de resténose chez le lapin. Chez le rat, après 30 jours, une hyperplasie limitée, l’absence de macrophage et une réendothélialisation des mailles ont été observées. Les premières implantations chez le lapin ont confirmé ces tendances mais l’étude doit être élargie afin d’en tirer une conclusion plus fiable. En conclusion, ces données démontrent que le Dex-PBMA est un matériau intéressant pour le revêtement de stent.

The purpose of this work was to study the biocompatibility of a dextran-graft-polybutylmethacrylate copolymer coated on cobalt chromium metallic stent. This study was divided in 3 parts: 1/the production of the copolymer and its physico-chemical characterization; 2/ its in vitro evaluation and 3/ its in vivo evaluation in several models. In the first step, 2 copolymers with different concentrations were synthetized and shaped for the following experiments. Their FTIR examination, contact angle measurement and a first in vivo implantation to evaluate foreign body reaction lead to the selection of one copolymer: the Dex-PBMA. No chronicle inflammatory reaction was noticed. Dynamic tests and SEM observations of coated stents confirmed the presence and the resistance of the Dex-PBMA coating. In vitro tests showed both low bacterial and platelet adhesions and a moderate thrombogenicity. An ex vivo test under flow with a model molecule – the Tacrolimus – showed the ability of Dex-PBMA to deliver drug. In vitro, the human endothelial progenitors and mesenchymal stem cells adhesion and proliferation were low but didn’t reveal any toxic effect. Finally…

Advisors/Committee Members: Letourneur, Didier (thesis director), Pellé, Anne (thesis director).

Subjects/Keywords: Revêtement de stent; Hémocompatibilité; Dextrane; Stent coating; Copolymer; Hemocompatibility; Dextran; 600

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Delattre, C. (2015). Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2015USPCD061

Chicago Manual of Style (16^th Edition):

Delattre, Cécilia. “Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application.” 2015. Doctoral Dissertation, Sorbonne Paris Cité. Accessed June 19, 2019. http://www.theses.fr/2015USPCD061.

MLA Handbook (7^th Edition):

Delattre, Cécilia. “Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application.” 2015. Web. 19 Jun 2019.

Vancouver:

Delattre C. Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2015. [cited 2019 Jun 19]. Available from: http://www.theses.fr/2015USPCD061.

Council of Science Editors:

Delattre C. Mise au point et évaluation de nouveaux revêtements de stents pour application cardio-vasculaire : Design of a new stent for cardiovascular application. [Doctoral Dissertation]. Sorbonne Paris Cité; 2015. Available from: http://www.theses.fr/2015USPCD061

University of Alberta

21. Zhao, YUewen. Role of RASSF1A in intestinal inflammation.

Degree: MS, Department of Biochemistry, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/pr76f457z

► Ras association domain family 1 A (RASSF1A) is an important tumor suppressor, which expression is frequently lost in various cancers due to promoter hypermethylation. Chronic… (more)

Subjects/Keywords: RASSF1A; dextran sodium sulphate; intestinal inflammation; NF-κB

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhao, Y. (2011). Role of RASSF1A in intestinal inflammation. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/pr76f457z

Chicago Manual of Style (16^th Edition):

Zhao, YUewen. “Role of RASSF1A in intestinal inflammation.” 2011. Masters Thesis, University of Alberta. Accessed June 19, 2019. https://era.library.ualberta.ca/files/pr76f457z.

MLA Handbook (7^th Edition):

Zhao, YUewen. “Role of RASSF1A in intestinal inflammation.” 2011. Web. 19 Jun 2019.

Vancouver:

Zhao Y. Role of RASSF1A in intestinal inflammation. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2019 Jun 19]. Available from: https://era.library.ualberta.ca/files/pr76f457z.

Council of Science Editors:

Zhao Y. Role of RASSF1A in intestinal inflammation. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/pr76f457z

Virginia Tech

22. Kittle, Joshua Daniel. Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers.

Degree: PhD, Chemistry, 2012, Virginia Tech

URL: http://hdl.handle.net/10919/26806

► As the two most abundant natural polymers on earth, cellulose and chitin have attracted increasing attention as a source of renewable energy and functional materials.… (more)

▼ As the two most abundant natural polymers on earth, cellulose and chitin have attracted increasing attention as a source of renewable energy and functional materials. Thin films of cellulose and chitin are useful for studying interactions of these materials with other natural and synthetic molecules via techniques such as quartz crystal microbalance with dissipation monitoring (QCM-D) and surface plasmon resonance (SPR). Because of the difficulty of extracting native cellulose, regenerated cellulose (RC), sulfated nanocrystalline cellulose (SNC), and desulfated nanocrystalline cellulose (DNC) thin films are often studied in its place. In this work, QCM-D solvent exchange studies showed that water contents of RC, SNC and DNC films were proportional to the film thickness (d). Accessibility and degradation of the films was further analyzed via substrate exposure to cellulase. Cellulase adsorption onto RC films was independent of d, whereas cellulase adsorption onto SNC and DNC films increased with d. Enhanced access to guest molecules for SNC and DNC films relative to RC films revealed they are more porous. The porosity of these cellulose films aided in understanding the observed differences of xyloglucan (XG) adsorption onto their surfaces. Xyloglucan adsorption onto RC, SNC, and DNC was studied by QCM-D and SPR. The amount of adsorbed XG increased in the order RC < SNC < DNC. XG adsorption onto RC films was independent of d, whereas XG adsorption was weakly dependent upon d for SNC films and strongly dependent upon d for DNC films. However, XG adsorbed onto "monolayer" thin films of RC, SNC, and DNC in approximately the same amount. These results suggested that the morphology and surface charge of the cellulose substrate had a limited effect upon XG adsorption and that accessible surface area of the cellulose film may be the factor leading to apparent differences in XG adsorption for different surfaces. The porosity and surface charge of SNC films presented a unique opportunity to examine polyelectrolyte adsorption and subsequent dewatering of the SNC substrate. The adsorption of a series of cationically derivatized dextran (cDex) polyelectrolytes with various degrees of substitution (DS) onto SNC was studied using QCM-D and SPR. As the hydrophobic character of the cDex samples increased, the water content of the adsorbed cDex layer decreased. For cDex with the greatest hydrophobic content, nearly 50% by mass of the initial water present in the porous SNC film was removed upon cDex adsorption. This study indicated that the water content of the film could be tailored by controlling the DS and hydrophobic character of the polyelectrolyte. This work also presents the first report of smooth, homogeneous, ultrathin chitin films, opening the door to surface studies of binding interactions, adsorption kinetics, and enzymatic degradation. The chitin films were formed by spincoating trimethylsilyl chitin onto gold or silica substrates, followed by regeneration to a chitin film. The utility of these chitin films… Advisors/Committee Members: Esker, Alan R. (committeechair), Troya, Diego (committee member), Morris, John R. (committee member), Madsen, Louis A. (committee member).

Subjects/Keywords: Chitin; Cellulose; Surface Plasmon Resonance; Quartz Crystal Microbalance; Xyloglucan; Dextran

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kittle, J. D. (2012). Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26806

Chicago Manual of Style (16^th Edition):

Kittle, Joshua Daniel. “Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers.” 2012. Doctoral Dissertation, Virginia Tech. Accessed June 19, 2019. http://hdl.handle.net/10919/26806.

MLA Handbook (7^th Edition):

Kittle, Joshua Daniel. “Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers.” 2012. Web. 19 Jun 2019.

Vancouver:

Kittle JD. Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10919/26806.

Council of Science Editors:

Kittle JD. Characterization of Cellulose and Chitin Thin Films and Their Interactions with Bio-based Polymers. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/26806

University of Helsinki

23. Pynnönen, Henna. Metylointianalyysit polysakkaridien rakenteen määrittämisessä.

Degree: Department of Applied Chemistry and Microbiology; Helsingfors universitet, Agrikultur- och forstvetenskapliga fakulteten, Institutionen för tillämpad kemi och mikrobiologi, 2009, University of Helsinki

URL: http://hdl.handle.net/1975/9252

►

Tutkielman kirjallisuusosassa tarkasteltiin Ciucanun ja Kerekin (1984) sekä Hakomorin (1964) metylointimenetelmiä, metylointiolosuhteiden ja reagenssien sekä rakenteen vaikutusta metyloinnin onnistumiseen. Kokeellisessa osassa metyloitiin glukoosia ja glukoosin… (more)

▼

Tutkielman kirjallisuusosassa tarkasteltiin Ciucanun ja Kerekin (1984) sekä Hakomorin (1964) metylointimenetelmiä, metylointiolosuhteiden ja reagenssien sekä rakenteen vaikutusta metyloinnin onnistumiseen. Kokeellisessa osassa metyloitiin glukoosia ja glukoosin polymeereja: sellobioosia, isomaltoosia, pullulaania, kaupallista dekstraania sekä maitohappobakteerien Weissella confusan ja Leuconostoc citreumin tuottamia dekstraaneja. Metyloinnin onnistumista tarkasteltiin IR:n avulla. Metyloituja näytteitä käsiteltiin metanolyysillä ja happohydrolyysillä. Metylointituotteiden rakennetarkastelu tehtiin GC-MS-spektrien perusteella. GC-määrityksessä vertailtiin DB-1 ja HP-5 - kolonneja. Kahden tunnin metylointi ultraäänihauteessa antoi hyviä metylointituloksia. IRmenetelmällä oli helppo tarkistaa metyloinnin onnistuminen. OH-ryhmiä kuvaava piikki noin 3400 cm-1 puuttui sekä CH3-ryhmän liittymistä kuvaavat piikit noin 2900 ja 2800 cm-1 erottuivat helposti metyloituneista näytteistä. IR-menetelmällä voidaan tarkastaa metyloinnin onnistuminen ja tarvittaessa metyloida näytteet uudelleen ennen hydrolyysiä ja johdoksenmuodostusta. Metanolyysimenetelmällä jokaisesta metylointituotteesta erotettiin ?- ja ?- pyranoosimuodot. Happohydrolyysimenetelmässä pelkistyksen johdosta muodostui vain yhdet muodot metylointituotteista. Glukoosin, sellobioosin, isomaltoosin ja pullulaanin rakenne tunnistettiin molemmilla menetelmillä. Näiden näytteiden saannot olivat hyviä, tosin rinnakkaisten näytteiden välillä oli paljon eroa. Kaupallisen dekstraanin ja W. confusan tuottaman dekstraanin rakenne saatiin selvitettyä metanolyysimenetelmällä ja osittain happohydrolyysimenetelmällä. Näytteiden saannot tosin olivat pienet. L. citreumin tuottaman dekstraanin kuudesta rinnakkaisesta näytteestä vain yksi metyloitui. Dekstraanien metyloituvuutta voidaan jatkossa kehittää sekoitusaikaa pidentämällä sekä lämmitystä ja glyserolia lisäämällä.

Methylation analysis by Ciucanu and Kerek (1984) and Hakomori (1964) and the meaning of circumstances in the reaction, reaction parameters and structure of the sample were reviewed in this study. The experimental work consisted of methylation analysis of glucose, cellobiose, isomaltose, pullulan, commercial dextran and dextrans produced by lactic acid bacteria Weissella confusa and Leuconostoc citreum. The success of the methylation was controlled using the IR-method. Methylated samples were treated by methanolysis and acid hydrolysis. The structure analyses were carried out with GC-MSspectra. Two different columns: DB-1 and HP-5 were compared in the GC-analysis. Two hours methylation in the ultrasonic bath gave good methylation results. It was easy to control the methylation by IR-method. OH-peak (3400 cm-1) was absent and CH3- peaks (2900 and 2800 cm-1) were high after successful methylation. IR-spectroscopy is a valuable tool to check if methylation has been successful. Samples could be remethylated before hydrolysis and derivation if necessary. After methanolysis there were ?- and ?-pyranose forms from each…

Subjects/Keywords: dekstraani; metylointi; IR; metanolyysi; happohydrolyysi; GC-MS; dextran; methylation; methanolysis; acid hydrolysis; Livsmedelskemi; Food Chemistry; Elintarvikekemia; dekstraani; metylointi; IR; metanolyysi; happohydrolyysi; GC-MS; dextran; methylation; methanolysis; acid hydrolysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pynnönen, H. (2009). Metylointianalyysit polysakkaridien rakenteen määrittämisessä. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/1975/9252

Chicago Manual of Style (16^th Edition):

Pynnönen, Henna. “Metylointianalyysit polysakkaridien rakenteen määrittämisessä.” 2009. Masters Thesis, University of Helsinki. Accessed June 19, 2019. http://hdl.handle.net/1975/9252.

MLA Handbook (7^th Edition):

Pynnönen, Henna. “Metylointianalyysit polysakkaridien rakenteen määrittämisessä.” 2009. Web. 19 Jun 2019.

Vancouver:

Pynnönen H. Metylointianalyysit polysakkaridien rakenteen määrittämisessä. [Internet] [Masters thesis]. University of Helsinki; 2009. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1975/9252.

Council of Science Editors:

Pynnönen H. Metylointianalyysit polysakkaridien rakenteen määrittämisessä. [Masters Thesis]. University of Helsinki; 2009. Available from: http://hdl.handle.net/1975/9252

24. Lenoir, Loïc. Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats.

Degree: Docteur es, Nutrition, 2011, Clermont-Ferrand 1

URL: http://www.theses.fr/2011CLF1PP05

► La consommation de polyphénols, micronutriments largement répandus dans lesaliments d’origine végétale, a été associée à la diminution du risque de développement denombreuses pathologies telles que… (more)

▼ La consommation de polyphénols, micronutriments largement répandus dans lesaliments d’origine végétale, a été associée à la diminution du risque de développement denombreuses pathologies telles que maladies cardiovasculaires, maladies neurodégénérativesou cancers. Cet effet des polyphénols s’explique en partie par leurs propriétés antioxydanteset anti-inflammatoires. Du fait de leur faible absorption au niveau de l’intestin grêle, lespolyphénols sont présents en grande quantité dans le côlon où ils peuvent exercer cespropriétés. L’inflammation intestinale fait interagir le système immunitaire intestinal avecde nombreux facteurs environnementaux et est fréquemment associée à une augmentationdu stress oxydant via la production d’espèces réactives de l’oxygène par les cellulesimmunitaires. De nombreuses études ont montré, sur des modèles animaux d’inflammationintestinale, les effets protecteurs de certains polyphénols. La verveine odorante (Aloysiatriphylla (L’Hérit.) Britton) est une plante médicinale connue pour ses vertus thérapeutiquesdigestives et anti-spasmodiques et couramment consommée en infusion. L’infusé deverveine odorante contient de grandes quantités de polyphénols (acides phénoliquescomplexes et dérivés de flavones) et ses propriétés antioxydantes ont été mises en évidenceaussi bien in vitro qu’in vivo.L’objectif de cette thèse a donc été d'évaluer l’effet d’une consommation préventived’un infusé de verveine odorante à dose nutritionnelle (40 g/l et 4 g/l) sur le développementd’une inflammation intestinale modérée chez le rat. Des rats Wistar ont consommé commeboisson l’infusé de verveine seul pendant deux semaines puis associé à un agentinflammatoire, le sulfate de dextran sodique (DSS), à 4% pendant 7 ou 9 jours. L’effet de laverveine a été évalué sur différents paramètres cliniques (diarrhée, saignements rectaux,poids corporel), marqueurs de l’inflammation (longueur du côlon, score histologique,activité myéloperoxydase, cytokines) et du stress oxydant (peroxydation lipidique,glutathion, défenses antioxydantes enzymatiques). Les cellules immunitaires ont étéidentifiées dans le sang ainsi que dans les structures lymphoïdes secondaires par cytométrieen flux. Enfin l’étude du métabolisme des polyphénols en situation inflammatoire ou non aété initiée par l’analyse de l’excrétion urinaire des dérivés polyphénoliques.Lors d’une inflammation de 7 jours, la consommation préventive d’infusé deverveine à 40 g/l et 4 g/l retarde l’apparition de diarrhée et de saignements rectaux, limite larétraction du côlon et la diminution de la prise de poids des rats. Malgré l’absence d’effetsur l’activité myéloperoxydase, l’infusé à 40 g/l atténue les altérations histologiques de lamuqueuse colique induites par l’inflammation. L’infusé à 4 g/l stimule l’activité de lasuperoxyde dismutase et réduit la peroxydation lipidique. Les deux infusés modulent lespopulations de cellules immunitaires dans les structures lymphoïdes secondaires (ganglionsmésentériques et plaques de Peyer), en particulier les lymphocytes B et les… Advisors/Committee Members: Felgines, Catherine (thesis director).

Subjects/Keywords: Verveine odorante (Aloysia triphylla); Polyphénols; Inflammation intestinale; Stress oxydant; Immunité; Sulfate de dextran sodique; Rats; Lemon verbena (Aloysia triphylla); Polyphenols; Colitis; Oxidative stress; Gut immunity; Dextran sulfate sodium; Rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lenoir, L. (2011). Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats. (Doctoral Dissertation). Clermont-Ferrand 1. Retrieved from http://www.theses.fr/2011CLF1PP05

Chicago Manual of Style (16^th Edition):

Lenoir, Loïc. “Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats.” 2011. Doctoral Dissertation, Clermont-Ferrand 1. Accessed June 19, 2019. http://www.theses.fr/2011CLF1PP05.

MLA Handbook (7^th Edition):

Lenoir, Loïc. “Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats.” 2011. Web. 19 Jun 2019.

Vancouver:

Lenoir L. Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats. [Internet] [Doctoral dissertation]. Clermont-Ferrand 1; 2011. [cited 2019 Jun 19]. Available from: http://www.theses.fr/2011CLF1PP05.

Council of Science Editors:

Lenoir L. Effet protecteur des polyphénols de la verveine odorante dans un modèle d'inflammation colique chez le rat : Protective effect of lemon verbena polyphenols in a model of colonic inflammation in rats. [Doctoral Dissertation]. Clermont-Ferrand 1; 2011. Available from: http://www.theses.fr/2011CLF1PP05

Université de Lorraine

25. Koné, Tiangoua. Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium.

Degree: Docteur es, Génie civil, 2012, Université de Lorraine

URL: http://www.theses.fr/2012LORR0404

►

Un dispositif expérimental a été développé pour l'étude du couplage de la croissance d'un biofilm de Shewanella oneidensis MR-1 et du transport conservatif de l'Erioglaucine.… (more)

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Un dispositif expérimental a été développé pour l'étude du couplage de la croissance d'un biofilm de Shewanella oneidensis MR-1 et du transport conservatif de l'Erioglaucine. La croissance du biofilm a été suivie par mesure de conductivité hydraulique et par acquisition d'images à l'aide d'une caméra digitale. La fraction volumique du biofilm a été caractérisée par des essais d'élution d'une macromolécule (i.e. : le Bleu Dextran) par analogie avec les méthodes de chromatographie d'exclusion ou de filtration sur gel. Ainsi au bout de 29 jours, un biofilm quasi-homogène sur l'ensemble de la cellule d'écoulement (0,1×0,1×0,05m3) et équivalent à 50% du volume poral a été formé. L'influence de la croissance du biofilm sur les propriétés de transport du milieu a été évaluée. Les essais de transport conservatif de l'Erioglaucine effectués pour deux vitesses d'injection et à deux stades de croissance du biofilm (17 et 29 jours) ont montré l'influence d'hétérogénéités locales sur les paramètres de transport (i.e. : la porosité, la perméabilité et la dispersion hydrodynamique). Ainsi après 17 jours de culture quand le biofilm occupe partiellement le milieu poreux (moitié inférieure) un modèle à deux équations ou double milieu permet de caractériser le transport conservatif. A contrario après 29 jours de culture où le biofilm occupe tout le milieu poreux, un comportement fickien classique caractérise le transport. Les valeurs théoriques du coefficient de dispersion longitudinale prédites par la méthode de prise de moyenne volumique ont permis de reproduire de manière satisfaisante le comportement observé expérimentalement

An experimental device was performed for the study of coupling the growth of a Shewanella oneidensis MR-1 bacterial biofilm and the non reactive transport of Brilliant Blue FCF. The biofilm growth was monitored by hydraulic conductivity measurements and by image acquisition with a digital camera. The biofilm volume fraction was estimated through tracer experiments with a macromolecular tracer (i.e., Dextran Blue) as in size-exclusion chromatography or gel filtration chromatography. Then after 29 days of bacterial culture a quasi-homogenous biofilm was grown in the whole flow cell (0,1×0,1×0,05m3) occupying about 50% of void space volume. The influence of biofilm growth on porous media transport properties was evaluated. Conservative tracer experiments with Brilliant Blue FCF run at two hydrodynamic conditions and at two growth steps of biofilm (17 and 29 days) showed the influence of local heterogeneities on transport parameters (i.e., porosity, permeability and hydrodynamic dispersion). Then at 17 days of growth when the biofilm partially covers the porous medium (bottom half of the flow cell) a two-equation model or double-layer model was suitable to characterize the conservative transport. A contrario after 29 days of growth, when the biofilm covers the whole porous medium, a classical fickian model was convenient. Numerical values of longitudinal dispersion coefficient from volume averaging well fitted…

Advisors/Committee Members: Buès, Michel A. (thesis director), Golfier, Fabrice (thesis director), Oltean, Constantin (thesis director).

Subjects/Keywords: Biofilm; Shawenella oneidensis; Milieu Poreux; Transport Conservatif; Erioglaucine; Bleu Dextran; Prise de moyenne volumique; Biofilm; Shawenella oneidensis; Porous media; Conservative Transport; Brilliant Blue FCF; Dextran Blue; Volume Averaging; 660.284 2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koné, T. (2012). Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium. (Doctoral Dissertation). Université de Lorraine. Retrieved from http://www.theses.fr/2012LORR0404

Chicago Manual of Style (16^th Edition):

Koné, Tiangoua. “Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium.” 2012. Doctoral Dissertation, Université de Lorraine. Accessed June 19, 2019. http://www.theses.fr/2012LORR0404.

MLA Handbook (7^th Edition):

Koné, Tiangoua. “Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium.” 2012. Web. 19 Jun 2019.

Vancouver:

Koné T. Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium. [Internet] [Doctoral dissertation]. Université de Lorraine; 2012. [cited 2019 Jun 19]. Available from: http://www.theses.fr/2012LORR0404.

Council of Science Editors:

Koné T. Étude expérimentale du couplage entre croissance bactérienne et transport d'un polluant organique en milieu poreux : Experimental study of coupling between bacterial growth and transport of an organic pollutant in a porous medium. [Doctoral Dissertation]. Université de Lorraine; 2012. Available from: http://www.theses.fr/2012LORR0404

Brno University of Technology

26. Kolenová, Milada. Interakce dextranu s tenzidem SDS .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/81429

► Pred samotnou charakterizáciou interakcií dextranu s tenzidom SDS boli skúmané vlastnosti roztoku dextranu vo vode a v chloride sodnom. Najprv boli merané denzitometricky, pričom bola… (more)

Subjects/Keywords: Dextran; dodecylsulfát sodný; kritická micelárna koncentrácia; denzitometria; ultrazvuková spektroskopia s vysokým rozlíšením; hustota; ultrazvuková rýchlosť; Dextran; sodium dodecyl sulphate; critical micelle concentration; densitometry; high resolution ultrasonic spectroscopy; density; ultrasonic velocity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kolenová, M. (2018). Interakce dextranu s tenzidem SDS . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/81429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kolenová, Milada. “Interakce dextranu s tenzidem SDS .” 2018. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/81429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kolenová, Milada. “Interakce dextranu s tenzidem SDS .” 2018. Web. 19 Jun 2019.

Vancouver:

Kolenová M. Interakce dextranu s tenzidem SDS . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/81429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kolenová M. Interakce dextranu s tenzidem SDS . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/81429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

27. Stiborský, Filip. Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty.

Degree: 2012, Brno University of Technology

URL: http://hdl.handle.net/11012/4837

► V této diplomové práci byly studovány interakce v systému obsahující polyelektrolyt-tenzid při nízkých i vysokých koncentracích tenzidu. Při fluorescenčním měření byl použit pyren jako fluorescenční… (more)

Subjects/Keywords: Fluorescenční spektrofotometrie; povrchově aktivní látky; pyren; dextran; hyaluronan; polystyrensulfonát sodný; UVVIS spektroskopie; interakce; Fluorescence spectroscopy; surfactants; pyrene; dextran; hyaluronan; sodium polystyrene sulfonate; UV-VIS spectroscopy; interaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stiborský, F. (2012). Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/4837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stiborský, Filip. “Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty. ” 2012. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/4837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stiborský, Filip. “Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty. ” 2012. Web. 19 Jun 2019.

Vancouver:

Stiborský F. Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty. [Internet] [Thesis]. Brno University of Technology; 2012. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/4837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stiborský F. Srovnávací studie interakcí tenzidů s hyauronanem a jinými polyelektrolyty. [Thesis]. Brno University of Technology; 2012. Available from: http://hdl.handle.net/11012/4837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

28. Burešová, Natálie. Studium kvality hydrofobních domén ve fázově separovaných hydrogelech .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/80640

► Diplomová práce se zabývá studiem hydrofobních domén ve fázově separovaných hydrogelech. Byly použity dva typy polyelektrolytů (hyaluronan, dextran) a opačně nabitých tenzidů (karbethopendecinium bromid, dodecylsulfát… (more)

Subjects/Keywords: Hydrogel; hyaluronan; dextran; karbethopendecinium bromid; dodecylsulfát sodný; fluorescenční spektroskopie; pyren; nilská červeň; laurdan.; Hydrogel; hyaluronan; dextran; carbethopendecinium brodmide; sodium dodecylsulphate; flourescence spectroscopy; pyrene; nile red; laurdane.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burešová, N. (2018). Studium kvality hydrofobních domén ve fázově separovaných hydrogelech . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/80640

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Burešová, Natálie. “Studium kvality hydrofobních domén ve fázově separovaných hydrogelech .” 2018. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/80640.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Burešová, Natálie. “Studium kvality hydrofobních domén ve fázově separovaných hydrogelech .” 2018. Web. 19 Jun 2019.

Vancouver:

Burešová N. Studium kvality hydrofobních domén ve fázově separovaných hydrogelech . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/80640.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burešová N. Studium kvality hydrofobních domén ve fázově separovaných hydrogelech . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/80640

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

29. Máčala, Jakub. Fluorescenční sondy pro studium vlastností hydrogelových systémů .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/81794

► Tato bakalářská práce se zabývá možnostmi použití vybraných fluorescenčních sond ke studiu vlastností hydrogelových systémů. Vybranými fluorescenčními sondami byly Prodan pro studium polarity, HPTS pro… (more)

▼ Tato bakalářská práce se zabývá možnostmi použití vybraných fluorescenčních sond ke studiu vlastností hydrogelových systémů. Vybranými fluorescenčními sondami byly Prodan pro studium polarity, HPTS pro studium pH prostředí a komplex platiny [2,6-Bis(2-pyridyl)fenyl-C,N,N]chloroplatina kvůli svým unikátním fluorescenčním vlastnostem a potenciálu například pro měření přenosu energie v hydrogelových systémech. Spektrální vlastnosti fluoroforů byly nejprve definovány ve vybraném souboru rozpouštědel o různé polaritě pomocí metody stacionární fluorescenční spektroskopie. Vlastnosti sondy HPTS byly rovněž zkoumány v pufrech o různém pH. Následně byly připraveny hydrogely na bázi hyaluronan-septonex a na bázi dextran-SDS s inkorporovaným fluorescenčními sondami. Měření stacionární fluorescence fluoroforů z prostředí hydrogelů probíhalo pomocí optických vláken fluorimetru. Bylo zjištěno, že sondy Prodan a HPTS se zdají býti vhodným prostředkem ke studiu polarity a pH hydrogelů a pravděpodobně budou moci být použity pro studium hydrogelů i dalšími technikami, jako je fluorescenční mikroskopie, zatímco komplex platiny je kvůli nízké intenzitě fluorescence a možnému zhášení polárním vodným prostředím nejspíše dále nepoužitelným pro další měření.; This bachelors thesis is focused on possibility of selected fluorescent probes for study of properties of hydrogel systems. Chosen probes are Prodan for polarity study, HPTS for measurement of pH of the probe environment and platinum complex [2,6-Bis(2-pyridyl)fenyl-C,N,N]chloroplatinum(II) for its unique fluorescence properties and potential of energy transfer studies in hydrogel systems. Spectral properties of fluorophores were defined in selected set of solvents with different polarity with steady state fluorescence spectroscopy method. Properties of HPTS probe were also tested in buffers with different pH. Subsequently, hydrogels based on hyaluronan-septonex and dextran-SDS with incorporated fluorescence probes were prepared. Steady state fluorescence measurement of fluorophores from hydrogel were made using fluorimeter optical fibres. It was found, that probes Prodan and HPTS are suitable for study of polarity and pH of hydrogels and probably they will be able to be used for study of hydrogel with other techniques, like fluorescence microscopy, however platinum complex is, due to the low fluorescence intensity and possible quenching by polar water environment, probably not suitable for other measurements. Advisors/Committee Members: Mravec, Filip (advisor).

Subjects/Keywords: Hydrogel; hyaluronan; dextran; tenzidy; Septonex; SDS; ustálená fluorescence; sondy; fluorofory; fyzikální chemie; Hydrogel; hyaluronan; dextran; sufractants; Septonex; SDS; Steady State fluorescence; probes; flurophores; physical chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Máčala, J. (2018). Fluorescenční sondy pro studium vlastností hydrogelových systémů . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/81794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Máčala, Jakub. “Fluorescenční sondy pro studium vlastností hydrogelových systémů .” 2018. Thesis, Brno University of Technology. Accessed June 19, 2019. http://hdl.handle.net/11012/81794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Máčala, Jakub. “Fluorescenční sondy pro studium vlastností hydrogelových systémů .” 2018. Web. 19 Jun 2019.

Vancouver:

Máčala J. Fluorescenční sondy pro studium vlastností hydrogelových systémů . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/11012/81794.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Máčala J. Fluorescenční sondy pro studium vlastností hydrogelových systémů . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/81794

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Kola-Mustapha, Adeola Tawakalitu. Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs.

Degree: PhD, 2013, De Montfort University

URL: http://hdl.handle.net/2086/10243

► Active Pharmaceutical Ingredients with poor solubility have presented significant difficulties in drug product design and development including slow and ineffective absorption leading to inadequate and… (more)

▼ Active Pharmaceutical Ingredients with poor solubility have presented significant difficulties in drug product design and development including slow and ineffective absorption leading to inadequate and variable bioavailability. Therefore it has become increasingly desirable to overcome the low aqueous solubility of drug candidates and develop more novel and innovative formulation approaches to increase the dissolution rate of the poorly soluble drugs. This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic solvents. Plain and ibuprofen-loaded binary and ternary nanoconjugates were prepared using four modified co-precipitation techniques including melt solubilization; alkaline solubilization; surfactant solubilization and hydrotropic complexation techniques. A remarkably high loading capacity was achieved ranging from 89.05 to 99.49% across the four techniques and polymer-polymer ratio of 50:50 was found to be most efficient. All the four techniques reduced the size of ibuprofen (2.87 μm) significantly in the presence of 2.0 x10-3 mM of Diethylaminoethyl Dextran (DEAE-Dextran) in the order melt solubilization (203.25 nm) > alkaline solubilization (185.68 nm) > surfactant (Tween 80) solubilization (122.17 nm) > hydrotropic complexation (77.92 nm). 5.0 x 10-4 mM of chitosan also reduced the size of ibuprofen from 2872.12 to 10.70 nm (268-fold reduction). The FTIR spectroscopic analysis revealed electrostatic, hydrophobic and hydrogen bonding interaction between solubilized ibuprofen and the cationic polymers (DEAE-Dextran and chitosan) to form a new product (an amide). Polymer-polymer complexation also occurred between DEAE-Dextran and gellan as well as chitosan and gellan to a different extent depending on the mixing ratios. 1H and 13C NMR analysis confirmed the conjugation between ibuprofen and each of the cationic polymers as well as the formation of a new amide product. DSC thermal analysis showed that the nanoconjugates exhibited new broad and diffuse peaks confirming that they did exist in amorphous state as multiple complexes. The TGA thermograms of the binary nanoconjugates exhibited one step degradation profile compared with the physical mixture which exhibited two steps. However the ternary nanoconjugates exhibited two steps degradation profile confirming the formation of multiple complexes. Marked enhancement of drug release was achieved by the four techniques compared with the ibuprofen control. All the DG (DEAE-Dextran - Gellan) complexes exhibited a higher release profile than ibuprofen control. Fickian and non-Fickian anomalous mechanisms were deduced for the drug release of ibuprofen from the binary conjugates. The ternary nanoconjugates exhibited non-Fickian (anomalous) diffusion, Fickian diffusion and Super Case II transport release mechanisms. The ternary nanoconjugate hydrogels exhibited complete release (100%) within 48 h. The…

Subjects/Keywords: 615.1; Ibuprofen-DEAE-Dextran nanoconjugates; Ibuprofen-Chitosan nanoconjugates; bilayer films; composite films; polyelectrolyte complex hydrogels

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kola-Mustapha, A. T. (2013). Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs. (Doctoral Dissertation). De Montfort University. Retrieved from http://hdl.handle.net/2086/10243

Chicago Manual of Style (16^th Edition):

Kola-Mustapha, Adeola Tawakalitu. “Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs.” 2013. Doctoral Dissertation, De Montfort University. Accessed June 19, 2019. http://hdl.handle.net/2086/10243.

MLA Handbook (7^th Edition):

Kola-Mustapha, Adeola Tawakalitu. “Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs.” 2013. Web. 19 Jun 2019.

Vancouver:

Kola-Mustapha AT. Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs. [Internet] [Doctoral dissertation]. De Montfort University; 2013. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2086/10243.

Council of Science Editors:

Kola-Mustapha AT. Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs. [Doctoral Dissertation]. De Montfort University; 2013. Available from: http://hdl.handle.net/2086/10243

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