subject:(Dental pulp)

1. Buntarika Unat. An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress .

Degree: คณะทันตแพทยศาสตร์ ภาควิชาชีววิทยาช่องปากและระบบการบดเคี้ยว, 2017, Prince of Songkla University

URL: http://kb.psu.ac.th/psukb/handle/2016/12032

Subjects/Keywords: Dental pulp

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Unat, B. (2017). An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress . (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2016/12032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Unat, Buntarika. “An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress .” 2017. Thesis, Prince of Songkla University. Accessed April 19, 2021. http://kb.psu.ac.th/psukb/handle/2016/12032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Unat, Buntarika. “An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress .” 2017. Web. 19 Apr 2021.

Vancouver:

Unat B. An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress . [Internet] [Thesis]. Prince of Songkla University; 2017. [cited 2021 Apr 19]. Available from: http://kb.psu.ac.th/psukb/handle/2016/12032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Unat B. An in vitro evaluation of the expression of IL-1B and TNF-A in human periodontal ligament fibroblasts after exposure to mechanical vibration combined with combined with compressive stress . [Thesis]. Prince of Songkla University; 2017. Available from: http://kb.psu.ac.th/psukb/handle/2016/12032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

2. Taylor, Taneka. Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels.

Degree: 2014, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/18912

► The investigation of focal adhesion formation in response to odontogenic culture medium on two-dimensional (2D) glass provides a reference for three-dimensional (3D) cell attachment studies.… (more)

Subjects/Keywords: pulp regeneration; human dental pulp stem cell; dentin-pulp complex

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Taylor, T. (2014). Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/18912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taylor, Taneka. “Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels.” 2014. Thesis, University of Illinois – Chicago. Accessed April 19, 2021. http://hdl.handle.net/10027/18912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taylor, Taneka. “Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels.” 2014. Web. 19 Apr 2021.

Vancouver:

Taylor T. Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels. [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10027/18912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taylor T. Human Dental Pulp Stem Cell Adhesion and Viability Studies in Hybrid Hydrogels. [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/18912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

3. Abd-Elmeguid, Ashraf A.E. The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis.

Degree: PhD, Medical Sciences-Dentistry, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/9306t005v

► Traumatic dental injuries are very common in the first and second decades of life. Trauma, if severe, could result in irreversible changes such as root… (more)

▼ Traumatic dental injuries are very common in the first and second decades of life. Trauma, if severe, could result in irreversible changes such as root resorption and/or partial or complete pulp obliteration by hard tissue. Dental pulp calcific metamorphosis is the rapid calcification of the pulp soft tissue in response to trauma. It is characterised by the deposition of dentin-like and bone-like tissues inside the dental pulp. Total avulsion of teeth represents almost 16% of dental traumatic injuries where the replantation of teeth back into their socket is the first treatment of choice. Inflammatory cells and osteoclasts were reported in teeth replantation cases, highlighting the role of inflammation in this type of calcification. Accordingly, the hypothesis of the current research was that dental pulp calcification and inflammation are closely integrated mechanisms. The immuno-histochemical localisation of a calcification molecule, dentin matrix protein (DMP-1), in pulp inflammation was performed. This was followed by determining its possible role in mediating inflammation by testing its induction of interleukin-6 (IL-6) and IL-8 expression in pulp fibroblasts. This proinflammatory effect is enhanced using lipopolysaccharide (LPS). The inhibitor of p38 mitogen activated protein kinase (p38MAPK) (SB-203580) blocked this effect. Osteopontin (OPN) and osteocalcin (OCN) were also examined for their expression in pulp inflammation using western blot and immuno-histochemistry respectively. Vascular endothelial growth factor (VEGF) increased in response to OPN stimulation of pulp cells. DMP-1 induced the expression of OPN, OCN, alkaline phosphatase (AP) and VEGF. p38MAPK inhibitor decreased DMP-1- induced OPN, AP and VEGF to their normal expression. Recombinant human DMP-1 showed marked calcification of ferret dental pulp chambers and DMP-1 was localised at 2 and 6 weeks following the replantation of ferret premolars. In vivo blocking of the inflammatory effect of DMP-1 using p38MAPK inhibitor significantly decreased calcification inside the dental pulp at 2 and 6 weeks post replantation. It is concluded that the DMP-1 is involved in the development of calcific metamorphosis partly through its pro inflammatory effect. DMP-1 also promoted pulp cells proliferation, pro-inflammation, and angiogenesis. Our data demonstrate a novel therapeutic strategy by which dental pulp inflammation and calcification are prevented at the same time.

Subjects/Keywords: Osteocalcin in dental pulp inflammation; Osteopontin and dental pulp inflammation; Dentin Matrix protein-1 (DMP-1); Preventive endodontics; Pulp inflammation; Dental pulp; Calcific metamorphosis; Traumatic dental injuries; Pulp calcification

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abd-Elmeguid, A. A. E. (2012). The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/9306t005v

Chicago Manual of Style (16^th Edition):

Abd-Elmeguid, Ashraf A E. “The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis.” 2012. Doctoral Dissertation, University of Alberta. Accessed April 19, 2021. https://era.library.ualberta.ca/files/9306t005v.

MLA Handbook (7^th Edition):

Abd-Elmeguid, Ashraf A E. “The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis.” 2012. Web. 19 Apr 2021.

Vancouver:

Abd-Elmeguid AAE. The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Apr 19]. Available from: https://era.library.ualberta.ca/files/9306t005v.

Council of Science Editors:

Abd-Elmeguid AAE. The pro-inflammatory and calcification effects of DMP-1 on pulp fibroblasts. Implications for the prevention of dental pulp calcifc metamorphosis. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/9306t005v

4. Duque, Carla Caroline de Oliveira [UNESP]. Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento.

Degree: 2016, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/138853

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Made available in DSpace on 2016-05-23T20:16:17Z (GMT). No. of bitstreams: 1 duque_cco_me_arafo.pdf: 6964321 bytes, checksum: 22480753de2d82fb176b13a6a33d913e (MD5) Previous issue date: 2016-03-23

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tem sido demonstrado que a susceptibilidade do complexo dentino-pulpar aos efeitos adversos do clareamento dental apresenta uma relação direta com a espessura de esmalte/dentina do substrato dental. Desta forma, o objetivo do presente estudo foi avaliar o efeito estético e biológico de um gel clareador contendo 10% de peróxido de hidrogênio (H2O2) aplicado por diferentes períodos sobre a superfície de discos simulando a espessura de incisivos inferiores (ICI) e pré-molares superiores (PMS). Discos de esmalte/dentina, provenientes de incisivos bovinos, com 2,3 e 4,0 mm de espessura foram adaptados a câmaras pulpares artificiais e distribuídos nos Grupos ICI e PMS, respectivamente. O gel clareador com 10% de H2O2 foi aplicado na superfície de esmalte por 3x15, 1x15 ou 1x5 minutos. Como controle positivo, um gel com 35% de H2O2 aplicado por 3x15 minutos (protocolo tradicional) foi empregado. Nenhum tratamento foi realizado na superfície de esmalte no grupo controle negativo. O meio de cultura em contato com a dentina imediatamente após o clareamento (extrato) foi coletado e aplicado por 1 hora sobre células pulpares humanas. A viabilidade e morfologia celular foram avaliados imediatamente após exposição aos extratos (T1), bem como 72 horas pós-tratamento (T2). O estresse oxidativo e a quantificação do H2O2 nos extratos também foram analisados em T1. A atividade de ALP (atividade de fosfatase alcalina) e deposição de nódulos de mineralização (NM) foram avaliados em períodos de 14 e 21 dias pós-clareamento, respectivamente. De forma a avaliar a eficácia estética dos protocolos testados nas diferentes condições experimentais, mensurou-se ainda a alteração de cor (ΔE) durante seis sessões clareadoras. De uma forma geral, observou-se que todos os protocolos experimentais com gel a 10% de H2O2 promoveram diminuição dos efeitos deletérios promovidos pelo protocolo tradicional. O protocolo 10% 3x15 causou redução significativa na viabilidade celular em relação ao controle negativo no período T1, em ambos os Grupos ICI e PMS, sendo que as células expostas a este protocolo no Grupo ICI não demonstraram capacidade proliferativa em T2. As alterações morfológicas, a…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Costa, Carlos Alberto de Souza [UNESP].

Subjects/Keywords: Citotoxicidade; Clareamento dental; Polpa dental; Cytotoxicity; Tooth-bleaching; Dental pulp

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Duque, C. C. d. O. [. (2016). Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento. (Masters Thesis). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/138853

Chicago Manual of Style (16^th Edition):

Duque, Carla Caroline de Oliveira [UNESP]. “Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento.” 2016. Masters Thesis, Universidade Estadual Paulista (UNESP). Accessed April 19, 2021. http://hdl.handle.net/11449/138853.

MLA Handbook (7^th Edition):

Duque, Carla Caroline de Oliveira [UNESP]. “Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento.” 2016. Web. 19 Apr 2021.

Vancouver:

Duque CCdO[. Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento. [Internet] [Masters thesis]. Universidade Estadual Paulista (UNESP); 2016. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/11449/138853.

Council of Science Editors:

Duque CCdO[. Influência da espessura do substrato dental sobre a eficácia clareadora e citotoxicidade de diferentes protocolos de clareamento. [Masters Thesis]. Universidade Estadual Paulista (UNESP); 2016. Available from: http://hdl.handle.net/11449/138853

IUPUI

5. Azabi, Asma Abulqasem. The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii.

Degree: 2015, IUPUI

URL: http://hdl.handle.net/1805/8043

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Indiana University-Purdue University Indianapolis (IUPUI)

Background: Root canal disinfection is an essential requirement for the success of regenerative endodontics. Currently, the so-called triple antibiotic paste… (more)

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Indiana University-Purdue University Indianapolis (IUPUI)

Background: Root canal disinfection is an essential requirement for the success of regenerative endodontics. Currently, the so-called triple antibiotic paste (TAP) is considered the standard of care. Notwithstanding the good antimicrobial capacity, the high concentration of TAP has shown significant toxicity to human cells, especially dental pulp stem cells. A novel drug release system, i.e., a triple antibiotic paste-mimic electrospun scaffold containing low concentrations of the antibiotics present in the TAP, has emerged as an effective and reliable alternative to fight root canal infections without potential toxic effects on dental stem cells, which are an integral part of the regenerative treatment. Objectives: The aim of this study was to determine the antimicrobial efficacy of an innovative three-dimensional (3D) triple antibiotic paste-mimic tubular scaffold against Actinomyces naeslundii biofilm formed inside human root canal dentinal tubules. Materials and methods: Pure polydioxanone (PDS) polymer solution and PDS loaded with metronidazole, ciprofloxacin and minocycline (35 wt.% of each antibiotic, 3D-TAP-mimic scaffold) were spun into 3D fibrous scaffolds. A. naeslundii (ATCC 43146) was centrifuged to induce biofilm formation inside human root canal dentinal tubules using a dentin slice model (1 mm thickness and 2.5 mm canal diameter). The infected dentin slices were exposed to the 3D-TAP-mimic scaffold, TAP solution (50 mg/mL of each antibiotic), and antibiotic-free PDS. Biofilm elimination was quantitatively and qualitatively analyzed by confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM), respectively. Results: A dense penetration of A. naeslundii biofilm was observed by CLSM throughout the dentinal tubules. 3D-TAP-mimic scaffold significantly reduced the percentage of viable bacteria compared with PDS (p <.05). TAP solution completely eliminated viable bacteria without differing from 3D-TAP-mimic scaffolds. SEM images showed results similar to CLSM. Conclusion: Collectively, the proposed tubular 3D-TAP-mimic scaffold holds significant clinical potential for root canal disinfection strategy prior to regenerative endodontics.

Advisors/Committee Members: Bottino, Marco C., Gregory, Richard L., Spolnik, Kenneth J., Cook, Norman Blaine, 1954-, Chu, Tien-Min Gabriel.

Subjects/Keywords: Biofilm; Regeneration; Pulp; Nanofibers; Scaffold; Biofilms; Regeneration; Dental Pulp; Nanofibers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Azabi, A. A. (2015). The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/8043

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Azabi, Asma Abulqasem. “The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii.” 2015. Thesis, IUPUI. Accessed April 19, 2021. http://hdl.handle.net/1805/8043.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Azabi, Asma Abulqasem. “The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii.” 2015. Web. 19 Apr 2021.

Vancouver:

Azabi AA. The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii. [Internet] [Thesis]. IUPUI; 2015. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/1805/8043.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Azabi AA. The antimicrobial efficacy of innovative 3D triple antibiotic paste-mimic tubular scaffold against actinomyces naeslundii. [Thesis]. IUPUI; 2015. Available from: http://hdl.handle.net/1805/8043

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

6. Cao, Yangpei. Senescing Effects of Ionizing Radiation on Dental Pulp Cells.

Degree: Oral Biology, 2014, UCLA

URL: http://www.escholarship.org/uc/item/99n2s21g

► It was hypothesized that IR triggered premature senescence in dental pulp, resulting in loss of mineralization potential and enhanced expression of senescence-associated inflammation. It was… (more)

Subjects/Keywords: Dentistry; Dental pulp cells; Ionizing radiation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cao, Y. (2014). Senescing Effects of Ionizing Radiation on Dental Pulp Cells. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/99n2s21g

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cao, Yangpei. “Senescing Effects of Ionizing Radiation on Dental Pulp Cells.” 2014. Thesis, UCLA. Accessed April 19, 2021. http://www.escholarship.org/uc/item/99n2s21g.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cao, Yangpei. “Senescing Effects of Ionizing Radiation on Dental Pulp Cells.” 2014. Web. 19 Apr 2021.

Vancouver:

Cao Y. Senescing Effects of Ionizing Radiation on Dental Pulp Cells. [Internet] [Thesis]. UCLA; 2014. [cited 2021 Apr 19]. Available from: http://www.escholarship.org/uc/item/99n2s21g.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cao Y. Senescing Effects of Ionizing Radiation on Dental Pulp Cells. [Thesis]. UCLA; 2014. Available from: http://www.escholarship.org/uc/item/99n2s21g

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

7. Ho, Wai-mei. A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction.

Degree: 1999, University of Hong Kong

URL: http://hdl.handle.net/10722/50923

Subjects/Keywords: Dental pulp - Diseases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ho, W. (1999). A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/50923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ho, Wai-mei. “A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction.” 1999. Thesis, University of Hong Kong. Accessed April 19, 2021. http://hdl.handle.net/10722/50923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ho, Wai-mei. “A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction.” 1999. Web. 19 Apr 2021.

Vancouver:

Ho W. A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction. [Internet] [Thesis]. University of Hong Kong; 1999. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10722/50923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ho W. A microbiological study of endodontically treated teeth associated with asymptomatic peri-radicular rarefaction. [Thesis]. University of Hong Kong; 1999. Available from: http://hdl.handle.net/10722/50923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. poimenova, anna. Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης.

Degree: 2018, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/43098

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Objectives. Early responses of human pulp to Prime&Bond / phosphoric acid, Clearfil SE Bond, Clearfil S3 Bond and Dycal were investigated ex vivo. Materials and… (more)

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Objectives. Early responses of human pulp to Prime&Bond / phosphoric acid, Clearfil SE Bond, Clearfil S3 Bond and Dycal were investigated ex vivo. Materials and Methods. The three adhesives, Dycal or buffer (DPBS) were applied directly onto the pulp of human teeth slices that were placed in culture for 4 days. Cell viability was monitored by the MTT assay during the culture period. After 4 days, tissue integrity was examined by hematoxylin-eosin staining. Vimentin levels were assessed by Western blotting. TUNEL assay was applied for apoptotic cell detection at specific pulp areas. Results. Profound reduction of cell viability and tissue integrity was observed in adhesive-treated groups, while the impact of Dycal was found to be less harmful. Extended apoptosis was caused mostly by the Clearfil SE and Prime&Bond. All adhesives reduced Vimentin levels. Significance. The study provides evidence that early pulp responses to direct capping with different adhesive systems or calcium hydroxide may vary significantly and underline the need for further studies in relevant ex vivo systems.

Σκοπός: Ο σκοπός της παρούσας ex vivo μελέτης ήταν η εξέταση των πρώιμων κυτταρικών αποκρίσεων του πολφού στην άμεση κάλυψή του με τρία συγκολλητικά συστήματα συνθέτων ρητινών (Prime&Bond NT, Clearfil SE Bond και Clearfil S3 Bond) και το Dycal. Οι παράμετροι που εξετάστηκαν περιλάμβαναν την ζωτικότητα και την ιστική ακεραιότητα του πολφού, την απόπτωση των κυττάρων του καθώς και την έκφραση της Βιμεντίνης, του ERdj5 και του TGFβ2. Υλικά και Μέθοδος:Τα συγκολλητικά συστήματα, το Dycal και το ρυθμιστικό διάλυμα (DPBS) εφαρμόστηκαν άμεσα σε τομές πολφού ανθρώπινων δοντιών διατηρημένων σε θρεπτικό μέσο κυτταροκαλλιέργειας για 4 μέρες. Η εκτίμηση της ζωτικότητας του ιστού κατά τη διάρκεια της παραμονής του σε καλλιέργεια έγινε με την εφαρμογή της χρώσης ΜΤΤ. Μετά το πέρας των τεσσάρων ημερών, η ακεραιότητα του ιστού εκτιμήθηκε με τη χρώση αιματοξυλίνης-ηωσίνης, την ανοσοϊστοχημική χρώση και την ανοσοστύπωση κατά Western για τη Βιμεντίνη, καθώς και με τη μέθοδο TUNEL για τον εντοπισμό των αποπτωτικών κυττάρων. Η εκτίμηση του στρες του Ενδοπλασματικού Δικτύου και της ιστικής ανάπλασης πραγματοποιήθηκε με την ανοσοϊστοχημική χρώση και την ανοσοστύπωση κατά Western για την πρωτεΐνη-δείκτη στρες του ενδοπλασματικού δικτύου ERdj5 και τον αυξητικό παράγοντα TGFβ2, αντίστοιχα. Αποτελέσματα:Τα αποτελέσματα της μελέτης έδειξαν ότι οι πρώιμες αποκρίσεις του πολφού στην άμεση κάλυψή του με τους εξεταζόμενους συγκολλητικούς παράγοντες και το Dycal διαφέρουν σημαντικά. Σημαντική μείωση της ζωτικότητας των κυττάρων και διατάραξη της ακεραιότητας του ιστού παρατηρήθηκε στις ομάδες όπου εφαρμόστηκαν τα συγκολλητικά συστήματα. Λιγότερο σημαντική επίδραση είχε η εφαρμογή του Dycal. Εκτεταμένη απόπτωση προκάλεσαν το Clearfil SE και το Prime&Bond. Το Dycal προκάλεσε περιορισμένη απόπτωση στην περιοχή της εφαρμογής του. Όλα τα συγκολλητικά συστήματα μείωσαν τα επίπεδα της Βιμεντίνης και του TGFβ2 στην περιοχή της εφαρμογής. Τα συνολικά επίπεδα της Βιμεντίνης στον…

Subjects/Keywords: άμεση κάλυψη πολφού; dental pulp capping

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APA (6^th Edition):

poimenova, a. (2018). Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/43098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

poimenova, anna. “Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης.” 2018. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 19, 2021. http://hdl.handle.net/10442/hedi/43098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

poimenova, anna. “Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης.” 2018. Web. 19 Apr 2021.

Vancouver:

poimenova a. Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10442/hedi/43098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

poimenova a. Ex vivo μελέτη των κυτταρικών αποκρίσεων του ανθρώπινου πολφού σε συγκολλητικούς παράγοντες κατά τα πρώιμα στάδια της διεργασίας επούλωσης. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. Available from: http://hdl.handle.net/10442/hedi/43098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Thanh Huy Thai. Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp .

Degree: คณะทันตแพทยศาสตร์ ภาควิชาศัลยศาสตร์, 2016, Prince of Songkla University

URL: http://kb.psu.ac.th/psukb/handle/2016/11441

Subjects/Keywords: Dental pulp; Fibronectins

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APA (6^th Edition):

Thai, T. H. (2016). Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp . (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2016/11441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thai, Thanh Huy. “Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp .” 2016. Thesis, Prince of Songkla University. Accessed April 19, 2021. http://kb.psu.ac.th/psukb/handle/2016/11441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thai, Thanh Huy. “Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp .” 2016. Web. 19 Apr 2021.

Vancouver:

Thai TH. Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp . [Internet] [Thesis]. Prince of Songkla University; 2016. [cited 2021 Apr 19]. Available from: http://kb.psu.ac.th/psukb/handle/2016/11441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thai TH. Evaluation of new bone formation in rabbit calvarial defects induced by silk fibroin scaffolds coated with fibronectin and decellularized dental pulp . [Thesis]. Prince of Songkla University; 2016. Available from: http://kb.psu.ac.th/psukb/handle/2016/11441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Sutiwa Benjakul. Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro .

Degree: คณะทันตแพทยศาสตร์ ภาควิชาชีววิทยาช่องปากและระบบการบดเคี้ยว, 2017, Prince of Songkla University

URL: http://kb.psu.ac.th/psukb/handle/2016/11644

Subjects/Keywords: Dental pulp; Periodontium

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APA (6^th Edition):

Benjakul, S. (2017). Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro . (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2016/11644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Benjakul, Sutiwa. “Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro .” 2017. Thesis, Prince of Songkla University. Accessed April 19, 2021. http://kb.psu.ac.th/psukb/handle/2016/11644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Benjakul, Sutiwa. “Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro .” 2017. Web. 19 Apr 2021.

Vancouver:

Benjakul S. Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro . [Internet] [Thesis]. Prince of Songkla University; 2017. [cited 2021 Apr 19]. Available from: http://kb.psu.ac.th/psukb/handle/2016/11644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Benjakul S. Effects of Low Magnitude High Frequency Mechanical Vibration Combined with Compressive Force on RANKL/OPG and Runx2 Expression in Human periodontal Ligament Cells in vitro . [Thesis]. Prince of Songkla University; 2017. Available from: http://kb.psu.ac.th/psukb/handle/2016/11644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

11. Boyle, Michael J. Cytoskeletal Reorganization in Human Dental Pulp Stem Cells.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19379

► Cytoskeletal f-actin reorganization is essential in many cellular processes. It has been shown that as stem cells differentiate along various lineages they undergo a unique… (more)

▼ Cytoskeletal f-actin reorganization is essential in many cellular processes. It has been shown that as stem cells differentiate along various lineages they undergo a unique change in cytoskeletal organization. In dental pulp regeneration, dental pulp stem cells differentiate to replace lost or damaged odontoblasts. Odontoblasts are lineage commited cells found within the tooth whose responsibility is to maintain the mineralized tissue of the tooth. Dental-pulp inflammation is a complex process involving cellular microenvironment and mitogenic signaling. Exposure to inflammatory mediators induces downstream cellular events mediating angiogenic signaling, a process crucial for pulpal inflammation and repair. Further, inflammation has been shown to initiate certain changes in cytoskeletal organization. Also, it has been demonstrated that certain materials commonly used in dentistry may be play a role in the regeneration response of dental pulp stem cells. Several studies have addressed the effects of proinflammatory stimuli on the survival and differentiation of dental-pulp stem cells. However, the mechanisms common to the inflammatory and angiogenic signaling involved in DPSC survival and differentiation remain unknown. Our studies observed that short-term exposure to TNF-α induced apoptosis with an upregulation of NF-κB signaling. In contrast, long-term exposure resulted in an increased proliferation with an associated telomere length shortening. Interestingly, DPSC pretreated with Nemo binding domain peptide, a cell permeable NF-κB inhibitor, significantly ameliorated TNF-α-induced increases in proliferation and the shortening of telomere length. Furthermore, NBD peptide pretreatment significantly ameliorated TNF-α-induced downregulation of proteins essential for differentiation, such as bone morphogenic proteins. Furthermore, inhibition of NF-κB signaling markedly increased the mineralization, abrogated by TNF-α signaling. Thus, our studies demonstrate that chronic inflammation mediates telomere shortening via NF-κB signaling in human DPSC. The resultant chromosomal instability leads to an emergence of angiogenic proliferation of DPSC and negative regulation of differentiation of DPSC, in vitro. Advisors/Committee Members: Alapati, Satish (advisor), Cho, Michael (committee member), Sun, Shan (committee member).

Subjects/Keywords: actin; dental pulp; regeneration; inflammation; angiogenesis

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APA (6^th Edition):

Boyle, M. J. (2015). Cytoskeletal Reorganization in Human Dental Pulp Stem Cells. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boyle, Michael J. “Cytoskeletal Reorganization in Human Dental Pulp Stem Cells.” 2015. Thesis, University of Illinois – Chicago. Accessed April 19, 2021. http://hdl.handle.net/10027/19379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boyle, Michael J. “Cytoskeletal Reorganization in Human Dental Pulp Stem Cells.” 2015. Web. 19 Apr 2021.

Vancouver:

Boyle MJ. Cytoskeletal Reorganization in Human Dental Pulp Stem Cells. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10027/19379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boyle MJ. Cytoskeletal Reorganization in Human Dental Pulp Stem Cells. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

12. Alwafi, Hanadi. Effect of thymoquinone on odontogensis of human dental pulp cells.

Degree: Doctor of Science in Dentistry, Pediatric Dentistry, 2018, Boston University

URL: http://hdl.handle.net/2144/29856

► BACKGROUND: Thymoquinone (TQ) is one of the most active ingredients of Nigella sativa seed. TQ has a variety of pharmacologic properties including possess antinociceptive, antibacterial,… (more)

▼ BACKGROUND: Thymoquinone (TQ) is one of the most active ingredients of Nigella sativa seed. TQ has a variety of pharmacologic properties including possess antinociceptive, antibacterial, anti-inflammatory, anti-oxidative activities and osteogenic effects on bone cells. Because of these properties, TQ might play an important role in odontogenic effects on human dental pulp cells and be used as a pulp capping material. PURPOSE: This study evaluates the effect of TQ on the attachment efficiency, proliferation, and odontogenic differentiation of Human Dental Pulp Cells (HDPC's). The effect of TQ on odontogenic differentiation was also determined by evaluating alkaline phosphatase (ALP) activity and Dentin Sialoprotein (DSP) expression. METHODS: Human dental pulp cells were cultured in triplicate using growth media with various TQ concentrations: 5 μM, 10μM, 15μM, 30μM, and 0μM as a control group at 7 and 21 days. Crystal violet staining was used to determine cell attachment efficiency and cell proliferation. The proliferation rates were normalized to cell numbers of each group at 16 hours. Cell differentiation was assessed by evaluating ALP activity and DSP expression. The data were normalized on per million cells basis. Univariate analyses including ANOVA and Student’s t-test were conducted. RESULTS: Higher cell attachment efficiency was shown in all TQ groups at 16 hours (P<. 0001) except for the 5 μM group. A significantly higher cell proliferation rate was shown with low TQ concentration 5 μM at 7 days (P<. 0001) and at 21days (P<. 0.05). However, the cell proliferation rates decreased significantly with higher TQ concentrations at both time intervals (P< 0.0001). Similarly, prolifration rates decreased at 21 days TQ =10 μM (P< 0.0001) and TQ =15 μM (P=0.0006). Significantly higher levels of alkaline phosphatase activity were observed in all TQ groups at 7 days (P <0.0001) and at 21 days (P <0.0001). Dentin sialoprotein expression was significantly down regulated in all TQ groups at 7 days compared to the control (P <0.05), however, at day 21 only TQ =15 μM exhibited significant down regulation of DSP compared to the control (P <0.0001). CONCLUSION: All tested TQ concentrations significantly enhanced cell attachment efficiency at 16 hours except TQ =5 μM. Cell proliferation rates were increased significantly by low TQ concentration 5 μM, and decreased significantly with higher TQ concentration 30 μM at 7 and 21 days. TQ exhibits odontogenic potential by inducing a significant increase in ALP activity at 7 and 21 days. TQ did not have any effect on DSP expression at 21 days except TQ =15 μM which significantly decreased DSP expression. Advisors/Committee Members: Chou, Laisheng (advisor).

Subjects/Keywords: Dentistry; Dental pulp; Nigella sativa; Thymoquinone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alwafi, H. (2018). Effect of thymoquinone on odontogensis of human dental pulp cells. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/29856

Chicago Manual of Style (16^th Edition):

Alwafi, Hanadi. “Effect of thymoquinone on odontogensis of human dental pulp cells.” 2018. Doctoral Dissertation, Boston University. Accessed April 19, 2021. http://hdl.handle.net/2144/29856.

MLA Handbook (7^th Edition):

Alwafi, Hanadi. “Effect of thymoquinone on odontogensis of human dental pulp cells.” 2018. Web. 19 Apr 2021.

Vancouver:

Alwafi H. Effect of thymoquinone on odontogensis of human dental pulp cells. [Internet] [Doctoral dissertation]. Boston University; 2018. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/2144/29856.

Council of Science Editors:

Alwafi H. Effect of thymoquinone on odontogensis of human dental pulp cells. [Doctoral Dissertation]. Boston University; 2018. Available from: http://hdl.handle.net/2144/29856

Boston University

13. Auerbach, David. The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment.

Degree: MSin Dentistry, Endodontics, 1973, Boston University

URL: http://hdl.handle.net/2144/31730

► The purpose of this study was to evaluate and compare the effectiveness of a number of widely used endodontic medicaments for the emergency pulpotomy procedure.… (more)

Subjects/Keywords: Pulpotomy; Dental pulp

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APA (6^th Edition):

Auerbach, D. (1973). The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/31730

Chicago Manual of Style (16^th Edition):

Auerbach, David. “The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment.” 1973. Masters Thesis, Boston University. Accessed April 19, 2021. http://hdl.handle.net/2144/31730.

MLA Handbook (7^th Edition):

Auerbach, David. “The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment.” 1973. Web. 19 Apr 2021.

Vancouver:

Auerbach D. The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment. [Internet] [Masters thesis]. Boston University; 1973. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/2144/31730.

Council of Science Editors:

Auerbach D. The effectiveness of camphorated parachlorophenol, cresatin, eugenol and formocresol for the emergency pulpotomy prior to endodontic treatment. [Masters Thesis]. Boston University; 1973. Available from: http://hdl.handle.net/2144/31730

University of Illinois – Chicago

14. Cheng, William. Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23120

► The multipotent nature of dental pulp stem cells (DPSCs) promises regenerative endodontic potential. A specific microenvironment controls the differentiation capability of DPSCs. Oxygen is known… (more)

Subjects/Keywords: regenerative endodontics; dental pulp stem cells

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APA (6^th Edition):

Cheng, W. (2018). Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23120

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, William. “Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia.” 2018. Thesis, University of Illinois – Chicago. Accessed April 19, 2021. http://hdl.handle.net/10027/23120.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, William. “Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia.” 2018. Web. 19 Apr 2021.

Vancouver:

Cheng W. Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10027/23120.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng W. Role of p38 MAPK in Odontogenic Differentiation of Dental Pulp Stem Cells in Hypoxia. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23120

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

15. Jones, Taneka Denise. Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23337

► Although more than 16 million endodontic procedures are performed in the United States annually, reinfections and tooth fractures have prompted recent advances in tissue engineering… (more)

Subjects/Keywords: Extrusion-Based Bioprinting; Dental Pulp Tissue Engineering

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APA (6^th Edition):

Jones, T. D. (2018). Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Taneka Denise. “Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering.” 2018. Thesis, University of Illinois – Chicago. Accessed April 19, 2021. http://hdl.handle.net/10027/23337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Taneka Denise. “Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering.” 2018. Web. 19 Apr 2021.

Vancouver:

Jones TD. Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10027/23337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones TD. Extrusion Based Bioprinting: An In Vitro Model for Dental Pulp Tissue Engineering. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

16. Bernard Charles Kerkhove, Jr., 1935-. A clinical and television densitometric evaluation of the indirect pulp capping technique.

Degree: 1964, IUPUI

URL: http://hdl.handle.net/1805/4373

Indiana University-Purdue University Indianapolis (IUPUI) Advisors/Committee Members: McDonald, Ralph E..

Subjects/Keywords: Dental Pulp Capping

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bernard Charles Kerkhove, Jr., 1. (1964). A clinical and television densitometric evaluation of the indirect pulp capping technique. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/4373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bernard Charles Kerkhove, Jr., 1935-. “A clinical and television densitometric evaluation of the indirect pulp capping technique.” 1964. Thesis, IUPUI. Accessed April 19, 2021. http://hdl.handle.net/1805/4373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bernard Charles Kerkhove, Jr., 1935-. “A clinical and television densitometric evaluation of the indirect pulp capping technique.” 1964. Web. 19 Apr 2021.

Vancouver:

Bernard Charles Kerkhove, Jr. 1. A clinical and television densitometric evaluation of the indirect pulp capping technique. [Internet] [Thesis]. IUPUI; 1964. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/1805/4373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bernard Charles Kerkhove, Jr. 1. A clinical and television densitometric evaluation of the indirect pulp capping technique. [Thesis]. IUPUI; 1964. Available from: http://hdl.handle.net/1805/4373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

17. Page, James, 1939-. A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation.

Degree: 1966, IUPUI

URL: http://hdl.handle.net/1805/4365

►

Indiana University-Purdue University Indianapolis (IUPUI)

A study was made to develop a method for investigating the quantity and location of vascular leakage during acute inflammation… (more)

Subjects/Keywords: Pulpitis; Dental Pulp

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APA (6^th Edition):

Page, James, 1. (1966). A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Page, James, 1939-. “A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation.” 1966. Thesis, IUPUI. Accessed April 19, 2021. http://hdl.handle.net/1805/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Page, James, 1939-. “A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation.” 1966. Web. 19 Apr 2021.

Vancouver:

Page, James 1. A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation. [Internet] [Thesis]. IUPUI; 1966. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/1805/4365.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Page, James 1. A method for studying the permeability of the blood vessels of the dental pulp during acute inflammation. [Thesis]. IUPUI; 1966. Available from: http://hdl.handle.net/1805/4365

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Guthrie, T.J. (Thomas J.), 1929-2006. An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy.

Degree: 1959, IUPUI

URL: http://hdl.handle.net/1805/4152

Indiana University-Purdue University Indianapolis (IUPUI)

Subjects/Keywords: Dental Pulp

…x22; re n no·~ be c ppe . . t . b lth of th . c OJ.. pulp infla in 1.955 st ·· d… …x22;"' at. tion nd one lo and th abila: y o· the pulp o · · hould · ~ ch · s… …v t 1 p lp aetric pulp tQat w s n ·t J;ound date pos y ti ~ obSG p in o: p… …0 . pulp in · c i au n 0 count e He mn io . bout 1>. . p t;ten i ~ o. pu i.e…

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APA (6^th Edition):

Guthrie, T.J. (Thomas J.), 1. (1959). An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/4152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guthrie, T.J. (Thomas J.), 1929-2006. “An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy.” 1959. Thesis, IUPUI. Accessed April 19, 2021. http://hdl.handle.net/1805/4152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guthrie, T.J. (Thomas J.), 1929-2006. “An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy.” 1959. Web. 19 Apr 2021.

Vancouver:

Guthrie, T.J. (Thomas J.) 1. An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy. [Internet] [Thesis]. IUPUI; 1959. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/1805/4152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guthrie, T.J. (Thomas J.) 1. An investigation of the dental pulp hemogram as a diagnostic aid for vital pulp therapy. [Thesis]. IUPUI; 1959. Available from: http://hdl.handle.net/1805/4152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

19. Bhoj, Manasi. A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments.

Degree: 2015, University of Hong Kong

URL: http://hdl.handle.net/10722/224667

► A living, self-supporting pulp tissue replacement for patients remains a considerable bioengineering challenge. As yet there is no method for engineering a self-sustaining living pulp… (more)

▼ A living, self-supporting pulp tissue replacement for patients remains a considerable bioengineering challenge. As yet there is no method for engineering a self-sustaining living pulp tissue that can be successfully transplanted into the patient and have any beneficial clinical outcomes. The main reason for this failure is the inability to reconstitute a functional blood vessel tubular network within the engineered pulp tissue. In addition, it has yet not been possible to engineer the various anatomically distinct structures and architectures of the healthy pulp tissue. The idea is that a bio-engineered pulp-like structure prior to transplantation will accelerate integration and reduce the potential for complications. Recently new strides are being taken to make a functioning living pulp tissue using the latest step by step enhancements that are occurring in biomimetic molecular engineering. The use of this basic tissue engineering processes of living organic matter in fabrication is ensuring that prospective lab-made tissue products are biologically compatible. Systems built into biomaterials involving self-assembly, feedback mechanisms will lead to realistic tissue replicates. The new methods include, fabricating biomimetic tissue frameworks with an array of keystone biochemical cues and structural cues. Alternatively others are suggesting that it is feasible to stimulate natural repair using small molecules and temporary frameworks together or independently. A typical tissue engineering strategy that also promises to work is to combine mixed cell populations and growth factors in a scaffold microenvironment. The hypothesis is that recreating an early stage tissue microenvironment-one that resembles the postnatal constitution that will initiate the autonomous reconstruction of native pulp tissue in vitro. As a result, a coherent self-sustaining and self-supporting tissue construct is prepared for rapid integration and remodeling. Our purpose, in this study is to create the formative elements for pulp tissue that go on to develop and regenerate into a functional living pulp tissue. The objective were firstly, to combine dental mesenchymal stem cells and human umbilical vein endothelial cells with limited key growth factors within a space filling the aalginate hydrogel. Secondly, to test the capacity of these encapsulated stem cells for proliferationon, and lastly, measure the capture level for soluble bio-chemicals and test the capacity of the system to release growth factors in a slow, continuous fashion. These are critical performance issues for building pulp de novo. There are more to be tackled in later stages of developing this technology. An alginate-RGD conjugated gel was used to encapsulate adult dental pulp mesenchymal stem cells and human umbilical vein endothelial cells (HUVEC) in the ratio of 1:1. It also served as a means for the targeted delivery of two key growth factors 〖VEGF〗¹²¹ (Vascular endothelial growth factor) and FGF-2 (Fibroblastic growth factor) towards the population of cells. In the…

Subjects/Keywords: Biomimetics; Dental pulp

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APA (6^th Edition):

Bhoj, M. (2015). A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/224667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhoj, Manasi. “A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments.” 2015. Thesis, University of Hong Kong. Accessed April 19, 2021. http://hdl.handle.net/10722/224667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhoj, Manasi. “A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments.” 2015. Web. 19 Apr 2021.

Vancouver:

Bhoj M. A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments. [Internet] [Thesis]. University of Hong Kong; 2015. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10722/224667.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhoj M. A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments. [Thesis]. University of Hong Kong; 2015. Available from: http://hdl.handle.net/10722/224667

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

20. Flanagan, Michael B. Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells.

Degree: PhD, Medicine and Health Sciences, 2013, Louisiana State University

URL: etd-11182013-150645 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3709

► Stem cells exist in various tissues, including dental follicles and dental pulps. Adult stem cells (ASC) can be isolated from patients for autologous transplantation, which… (more)

▼ Stem cells exist in various tissues, including dental follicles and dental pulps. Adult stem cells (ASC) can be isolated from patients for autologous transplantation, which eliminates the risk of immune rejection with low or no tumorigenesis. However, one of the challenges is that ASC progressively lose their differentiation ability when cultured in vitro. This prevents expansion of large quantities of high-potential stem cells for therapeutics, especially for stem cells with limited tissue source, such as dental pulp stem cells (DPSC). The goal of this study is to define possible molecular regulation causing loss of differentiation. To achieve this goal, we determined that DPSC at passages 3 and 5 (early passage) possessed strong differentiation capability, and such differentiation capability is completely lost at passage 11 (late passage). Using whole-genome microarray to compare the transcriptomes, we found that the expression of 34 genes were decreased for more than 10-fold in p11 DPSC when compared to p3. After confirming gene expression with RT-PCR, heat shock protein B8 (HspB8) and the GIPC PDZ domain-containing family (Gipc2) were selected for siRNA knockdown study. Knockdown of HspB8 in early-passage DPSC resulted in the cells losing differentiation, but knockdown of Gipc2 had no effect, suggesting that HspB8 plays an important role in maintaining DPSC differentiation. To further study HspB8, we constructed 2 vectors, one containing the coding sequence (CDS) and 3’ untranslated region (3’UTR) and another containing only the CDS. Transfection of the vectors into early passage DPSC dramatically increased both HspB8 mRNA and protein. However, transfection of the vectors into the late passage DPSC resulted in overexpression of HspB8 mRNA, but increase of HspB8 protein was seen only in CDS transfection. Given that 3’UTR of mRNA is the major target region for microRNAs (miRNAs), the results indicate that miRNAs are responsible for down-regulation of HspB8 in long-term culture of DPSCs. We conclude that high-level HspB8 expression is essential for differentiation of DPSC, and down-regulation of HspB8 in cultured DPSC is likely due to increased expression of miRNAs. These are novel findings regarding HspB8 and miRNAs on the regulation of stem cell fate.

Subjects/Keywords: dental pulp; adult stem cell; DPSC; differentiation

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APA (6^th Edition):

Flanagan, M. B. (2013). Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-11182013-150645 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3709

Chicago Manual of Style (16^th Edition):

Flanagan, Michael B. “Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells.” 2013. Doctoral Dissertation, Louisiana State University. Accessed April 19, 2021. etd-11182013-150645 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3709.

MLA Handbook (7^th Edition):

Flanagan, Michael B. “Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells.” 2013. Web. 19 Apr 2021.

Vancouver:

Flanagan MB. Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells. [Internet] [Doctoral dissertation]. Louisiana State University; 2013. [cited 2021 Apr 19]. Available from: etd-11182013-150645 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3709.

Council of Science Editors:

Flanagan MB. Identification of genes responsible for maintenance of differentiation capability in dental pulp stem cells. [Doctoral Dissertation]. Louisiana State University; 2013. Available from: etd-11182013-150645 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3709

UCLA

21. Arasteh, Hobie H. Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity.

Degree: Oral Biology, 2015, UCLA

URL: http://www.escholarship.org/uc/item/8248p09f

► The aim of this study is to understand the role of immune regulators such as Natural Killer Cells and Monocytes with Dental Pulp Stem Cells… (more)

Subjects/Keywords: Dentistry; Immunology; Surgery; Dental Pulp; Dental Pulp Stomal Cells; FGF; immunology; Monocytes; Natural Killer cells

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APA (6^th Edition):

Arasteh, H. H. (2015). Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/8248p09f

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arasteh, Hobie H. “Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity.” 2015. Thesis, UCLA. Accessed April 19, 2021. http://www.escholarship.org/uc/item/8248p09f.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arasteh, Hobie H. “Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity.” 2015. Web. 19 Apr 2021.

Vancouver:

Arasteh HH. Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity. [Internet] [Thesis]. UCLA; 2015. [cited 2021 Apr 19]. Available from: http://www.escholarship.org/uc/item/8248p09f.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arasteh HH. Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity. [Thesis]. UCLA; 2015. Available from: http://www.escholarship.org/uc/item/8248p09f

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Malmö University

22. Fransson, Helena. On the repair of the dentine barrier .

Degree: Malmö University. Faculty of Odontology, 2012, Malmö University

URL: http://hdl.handle.net/2043/13824

► The overall aim of this thesis was to study some aspects of the repair of the dentine barrier, especially in conjunction with dental pulp capping.… (more)

▼ The overall aim of this thesis was to study some aspects of the repair of the dentine barrier, especially in conjunction with dental pulp capping. Understanding the events leading to the healing of the dentine and pulp, and hence successfully preserving the vitality and functions of the tooth, would lead to a scientific basis for a less invasive treatment of pulp exposures than performing root canal treatments. The surfaces of the body have physiological barrier functions aimed at protecting the body from external noxious agents. In the tooth, the odontoblasts, which line the outermost part of the pulp and are responsible for the formation of dentine, play a central role in the barrier function and thus in the defence mechanisms of the tooth. The micro-organisms in the caries lesion can reach the pulp via the dentinal tubules. However, the barrier function helps to prevent microbial invasion and thereby avoid deleterious inflammation and subsequent necrosis of the pulp. Dentine repair is an important part of the barrier function. There are however doubts as to whether the repair also leads to restitution of the function and the ability to withstand bacterial influx over the longer term. Pulp capping is a treatment method used when the pulp has been exposed in order to stimulate healing of the pulp and dentine. The evidence for repair of the dentine after pulp capping in humans has been studied by means of a systematic review. The focus of the literature search was studies performed in humans where hard tissue formation had been studied with the aid of a microscope. We concluded, based on the limited evidence available, that calcium hydroxide based materials but not bonding agents promote formation of a hard tissue bridge. Scientific evidence was lacking as to whether MTA was better than calcium hydroxide based materials in this regard. A gel (Emdogain®Gel) containing amelogenin, known to be involved in dentinogenesis, was evaluated with regard to formation of hard tissue in a clinical study. A greater amount of hard tissue was formed after application of the gel compared to the control. Characterization of the tissue concluded it to be dentine, based on its content of type 1 collagen and dentine sialoprotein, although it was not formed as a continuous bridge covering the pulp wound. Beneath a deep caries lesion an important part of the barrier function is the odontoblasts´ response to bacteria with the formation of new dentine. A cell model with odontoblasts was used to study the effects of clinical isolates from a deep carious lesion on their viability and production of type 1 collagen, the major component of the dentine in the early stages of its formation. There were bacteria that negatively affected the viability of the odontoblast-like cells and different bacteria varied in their effects on type 1 collagen production, suggesting that some bacteria may have a direct influence on the odontoblasts´ ability to form dentine. In summary; Emdogain®Gel initiated dentine formation, though not in a form…

Subjects/Keywords: dentine; dental pulp capping; immunohistochemistry; enamel matrix proteins; bacteria; dental pulp exposure

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fransson, H. (2012). On the repair of the dentine barrier . (Thesis). Malmö University. Retrieved from http://hdl.handle.net/2043/13824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fransson, Helena. “On the repair of the dentine barrier .” 2012. Thesis, Malmö University. Accessed April 19, 2021. http://hdl.handle.net/2043/13824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fransson, Helena. “On the repair of the dentine barrier .” 2012. Web. 19 Apr 2021.

Vancouver:

Fransson H. On the repair of the dentine barrier . [Internet] [Thesis]. Malmö University; 2012. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/2043/13824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fransson H. On the repair of the dentine barrier . [Thesis]. Malmö University; 2012. Available from: http://hdl.handle.net/2043/13824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

23. Czaperacker, Cynthia H. Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp.

Degree: 2016, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21272

► Introduction: Vital pulp therapy (VPT) and pulp regeneration or revascularization are current endodontic treatments that aim to either repair or regenerate dental pulp affected by… (more)

▼ Introduction: Vital pulp therapy (VPT) and pulp regeneration or revascularization are current endodontic treatments that aim to either repair or regenerate dental pulp affected by caries, trauma, or iatrogenic exposure. Teeth undergoing these procedures are usually in a state of inflammation ranging from reversible pulpitis to pulpal necrosis. This inflammatory microenvironment provides a unique challenge to the dental stem cells used in VPT or pulp revascularization. Leptin, an inflammation-related protein, and its receptor (Lep-R) have been shown to be upregulated in dental pulp stem cells (DPSCs) exposed to hypoxic conditions in vitro, simulating inflammation. This study investigates the difference in leptin expression and adipogenic differentiation potential between ex vivo dental pulp diagnosed as normal and irreversible pulpitis. Methods: In vitro (simulated stressor model): DPSCs were isolated from seven virgin, human extracted third molars with normal pulp. Half of the DPSCs were exposed to hypoxic (5% oxygen) conditions and the remaining half were cultured in normoxic (21% oxygen) conditions. DPSCs were evaluated for lipid accumulation using oil red O stain and light microscopy. Ex vivo (disease model): Dental pulp was procured from six, virgin, human extracted premolars with normal pulp and six, non-restorable carious, human extracted premolars and molars with irreversible pulpitis. Pulp tissue was analyzed for adipogenic lineage proteins using a BioPlex Luminex Assay (BioRad, CA, USA). Results: In vitro (simulated stressor model): DPSCs exposed to hypoxic conditions have a higher concentration of cells with lipid accumulation. Ex vivo (disease model): Leptin and Lep-R are significantly (p0.05) up-regulated in the irreversibly inflamed pulp compared to healthy pulp. Conclusions: This study demonstrates that the stress of hypoxia and caries-driven irreversible pulpitis drive differentiation of DPSCs towards an adipogenic lineage with increased leptin production. In the future, leptin may be employed as a therapeutic molecule in bioengineering models to facilitate regenerative endodontics. Advisors/Committee Members: Alapati, Satish (advisor), Johnson, Bradford (committee member), Colvard, Michael (committee member).

Subjects/Keywords: Vital pulp therapy; pulp revascularization; pulp regeneration; dental pulp stem cells; hypoxia; pulpitis; inflammation; leptin; pulpal necrosis

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APA (6^th Edition):

Czaperacker, C. H. (2016). Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21272

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Czaperacker, Cynthia H. “Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp.” 2016. Thesis, University of Illinois – Chicago. Accessed April 19, 2021. http://hdl.handle.net/10027/21272.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Czaperacker, Cynthia H. “Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp.” 2016. Web. 19 Apr 2021.

Vancouver:

Czaperacker CH. Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/10027/21272.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Czaperacker CH. Upregulation of Adipogenic Lineage Differentiation and Markers in Inflamed-Dental Pulp. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21272

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Simony Hidée Hamoy Kataoka. Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas.

Degree: 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23145/tde-19022015-153458/

►

O objetivos deste estudo foi avaliar a influência da radiação ionizante na vitalidade do tecido pulpar mensurada através dos níveis de saturação de oxigênio (%SpO2)… (more)

▼

O objetivos deste estudo foi avaliar a influência da radiação ionizante na vitalidade do tecido pulpar mensurada através dos níveis de saturação de oxigênio (%SpO2) em pacientes com tumores malígnos intraoral ou de orofaringe, passado de 4-6 anos da radioterapia (RT). Noventa pacientes com tumores malígnos intraoral ou de orofaringe, submetidos de 4-6 anos anteriores a RT foram selecionados para este estudo. Os níveis de oxigenação e sensibilidade pulpar, avaliados através do oxímetro de pulso e do spray refrigerante TFE (tetrafluoretano), foram analisados nos dentes anteriores (superior e inferior) de cada paciente selecionado (n=693),, indiferente do quadrante e da área irradiada. Como grupo controle foram selecionados noventa pacientes saudáveis (nunca submetidos a RT) e os mesmos testes foram empregados (n=693). Todos os dentes foram considerados vitais. 100% mostraram resposta positva ao teste térmico e as médias de %SpO2 foram de 92.7% no grupo dos pacientes irradiados (SD ± 1.83) e 92.6% no grupo dos não-irradiados (SD ± 1.80), sem diferença estatística observada. Houve uma tendência de valores de %SpO2 menores em dentes caninos comparados aos incisivos, entretanto sem diferença estatística significante. Passados de 4-6 anos da RT, as %SpO2 da polpa dental estão dentro dos padrões considerados normais para uma polpa vital e podese assumir que a RT não têm influência danosa a longo prazo sobre a vitalidade do tecido pulpar, assim sugerindo que este tecido pode ser apto a retornar o fluxo sanguíneo normal após a RT. As mudanças observadas na microcirculação pulpar devido a RT parecem ser temporárias, então o tratamento endodôntico preventivo ou a extração dental em pacientes que receberam radiação ionizante são desnecessários.

The aim of this study was to evaluate the influence of radioation on pulp vitality through the measurement of pulpal oxigenation levels (%SpO2) in patients with malignant intraoral and oropharyngeal tumors at 4-6 years after radiotherapy (RT). Ninety patients with malignant tumors in the oral cavity or oropharynx, submitted to RT 4-6 years prior to the study were selected. Pulp oxygenation levels and pulp sensitivity, measured by pulse oximetry and by cold refrigerant spray TFE (tetrafluoroethane), were analyzed in the anterior teeth (upper and lower) of each patient selected (n=693), regardless of the quadrant and the irradiated area. As a control group were selected ninety healthy patients (never submitted to RT) and the same tests were performed (n=693). All teeth were considered vital. 100% showed a positive response to the thermal test and the %SpO2 rates were 92.7% in irradiated group (SD ± 1.83) and 92.6% in non-irradiated group (SD ± 1.80), without statistical difference. There was a trend for lower %SpO2 values in canine teeth compared to incisors, however it was not statistically significant. After 4-6 years of RT the dental pulp %SpO2 are within the normal range considered for a vital pulp and it can be assumed that RT did not have a long term influence on the pulp…

Advisors/Committee Members: Celso Luiz Caldeira, Andrea Mantesso Pobocik, Eduardo Rodrigues Fregnani, Giulio Gavini, Eudes Gondim Junior, Oscar Faciola Pessoa.

Subjects/Keywords: Microcirculação; Polpa dental; Radioterapia; Dental Pulp; Microcirculation; Radiotheraphy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kataoka, S. H. H. (2014). Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23145/tde-19022015-153458/

Chicago Manual of Style (16^th Edition):

Kataoka, Simony Hidée Hamoy. “Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas.” 2014. Doctoral Dissertation, University of São Paulo. Accessed April 19, 2021. http://www.teses.usp.br/teses/disponiveis/23/23145/tde-19022015-153458/.

MLA Handbook (7^th Edition):

Kataoka, Simony Hidée Hamoy. “Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas.” 2014. Web. 19 Apr 2021.

Vancouver:

Kataoka SHH. Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Apr 19]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23145/tde-19022015-153458/.

Council of Science Editors:

Kataoka SHH. Avaliação dos efeitos tradios da radioterapia na microcirculação pulpar: Taxa de %SpO2 pulpar de pacientes irradiados para tumores malignos intraorais e de orofaringe. Tese apresentada à Faculdade de Odontologia da Universidade de São Paulo para obtenção do título de Doutor em Ciências Odontológicas. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/23/23145/tde-19022015-153458/

25. Soares, Diana Gabriela de Sousa [UNESP]. Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares.

Degree: 2014, Universidade Estadual Paulista (UNESP)

URL: http://hdl.handle.net/11449/114050

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Made available in DSpace on 2015-01-26T13:21:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-03-28Bitstream added on 2015-01-26T13:30:19Z : No. of bitstreams: 1 000806001_20170328.pdf: 531116 bytes, checksum: 4bcef8dc36e6fadb7f840876180a7545 (MD5) Bitstreams deleted on 2017-03-31T12:19:25Z: 000806001_20170328.pdf,. Added 1 bitstream(s) on 2017-03-31T12:20:23Z : No. of bitstreams: 1 000806001.pdf: 3239201 bytes, checksum: 56301903e59b57f9f74a836016abf9ac (MD5)

Nesta pesquisa, foram analisadas a eficácia clareadora, citotoxicidade e características fenotípicas de células pulpares expostas a protocolos de clareamento de consultório experimentais. No primeiro estudo, discos de esmalte/dentina foram submetidos a 6 sessões clareadoras, caracterizadas por 1 ou 3 aplicações de peróxido de hidrogênio (H2O2) a 35% ou 17,5%, por 5 ou 15 min, ou de peróxido de carbamida (PC) a 37%, por 10 ou 20 min. A alteração de cor (E) e quantificação da difusão de H2O2 (violeta leuco-cristal/peroxidase) foram avaliadas. Todos os protocolos testados promoveram alteração significativa de cor associados a redução na difusão de H2O2; no entanto, o gel com PC apresentou os piores resultados (Traço de Pilai; Bonferroni/p<0,05). Apenas os protocolos 35% H2O2/ 1x 15 e 3x 5 min, 17,5% H2O2/ 3x 15 min e 37% PC/ 3x 20 min apresentaram valores de E similares ao protocolo tradicional (35%/ 3x 15 min) em até 6 sessões de clareamento (ANOVA; SNK e Tamhane/p>0.05). No segundo estudo, foi avaliada a citotoxicidade trans-amelodentinária causada pela aplicação de protocolos experimentais usando 35% H2O2/ 1x 15 e 1x 5 min e 17,5% H2O2/ 3x 15, 1x 15 e 1x 5 min. O protocolo 35% H2O2/ 3x 15 min foi empregado como controle positivo. Os discos de esmalte/dentina foram adaptados em dispositivos trans-well, os quais foram posicionados sobre células odontoblastóides (MDPC-23) e cultura primária de células pulpares humanas (HDPCs) previamente semeadas. A viabilidade (MTT) e morfologia celular (MEV) foram avaliadas imediatamente e 72 h pós-clareamento, bem como o estresse oxidativo e lesão à membrana celular (microscopia de fluorescência). Todos os protocolos experimentais avaliados reduziram significativamente o dano celular quando comparados ao controle positivo (Kruskal-Wallis; Mann-Whitney/p<0,05). Esta redução foi tempo/concentração dependente. As células expostas aos protocolos com o gel contendo 17,5% de...

In this study, the bleaching effectiveness, cytotoxicity and phenotypic characteristic of dental pulp cells exposed to experimental in-office bleaching protocols were analyzed. In the first study, enamel/dentin discs were subjected to 6 bleaching sessions, composed by 1 or 3 applications of a 35%- or 17.5%-H2O2 (hydrogen peroxide) gel, during 5 or 15 minutes, or by a 37%-CP (carbamide peroxide) gel, applied for 10 or 20 minutes. Color change (E) and H2O2 diffusion (leucocrystal violet/ peroxidase) were analyzed. All the tested protocols promoted significant color alteration and reduction of H2O2 diffusion; however, the CP gel presented the…

Advisors/Committee Members: Universidade Estadual Paulista (UNESP), Costa, Carlos Alberto de Souza [UNESP].

Subjects/Keywords: Polpa dentaria; Clareamento dental; Reabilitação bucal; Dental pulp

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Soares, D. G. d. S. [. (2014). Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares. (Doctoral Dissertation). Universidade Estadual Paulista (UNESP). Retrieved from http://hdl.handle.net/11449/114050

Chicago Manual of Style (16^th Edition):

Soares, Diana Gabriela de Sousa [UNESP]. “Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares.” 2014. Doctoral Dissertation, Universidade Estadual Paulista (UNESP). Accessed April 19, 2021. http://hdl.handle.net/11449/114050.

MLA Handbook (7^th Edition):

Soares, Diana Gabriela de Sousa [UNESP]. “Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares.” 2014. Web. 19 Apr 2021.

Vancouver:

Soares DGdS[. Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares. [Internet] [Doctoral dissertation]. Universidade Estadual Paulista (UNESP); 2014. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/11449/114050.

Council of Science Editors:

Soares DGdS[. Novos parâmetros para o clareamento dental: avaliação da eficácia, citotoxicidade e efeitos moleculares. [Doctoral Dissertation]. Universidade Estadual Paulista (UNESP); 2014. Available from: http://hdl.handle.net/11449/114050

26. Schwendeman, Frederick J. D. Thermal pulpal insult from laser debonding ceramic brackets.

Degree: Certificate, 1995, Oregon Health Sciences University

URL: doi:10.6083/M4HX19X0 ; http://digitalcommons.ohsu.edu/etd/2759

Subjects/Keywords: Dental Debonding; Dental Enamel; Dental Pulp

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schwendeman, F. J. D. (1995). Thermal pulpal insult from laser debonding ceramic brackets. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4HX19X0 ; http://digitalcommons.ohsu.edu/etd/2759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schwendeman, Frederick J D. “Thermal pulpal insult from laser debonding ceramic brackets.” 1995. Thesis, Oregon Health Sciences University. Accessed April 19, 2021. doi:10.6083/M4HX19X0 ; http://digitalcommons.ohsu.edu/etd/2759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schwendeman, Frederick J D. “Thermal pulpal insult from laser debonding ceramic brackets.” 1995. Web. 19 Apr 2021.

Vancouver:

Schwendeman FJD. Thermal pulpal insult from laser debonding ceramic brackets. [Internet] [Thesis]. Oregon Health Sciences University; 1995. [cited 2021 Apr 19]. Available from: doi:10.6083/M4HX19X0 ; http://digitalcommons.ohsu.edu/etd/2759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schwendeman FJD. Thermal pulpal insult from laser debonding ceramic brackets. [Thesis]. Oregon Health Sciences University; 1995. Available from: doi:10.6083/M4HX19X0 ; http://digitalcommons.ohsu.edu/etd/2759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

27. Prateepchinda, Sagaw. Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D80864CN

► Over 15 million root canal treatments (RCT) are performed yearly in the United States to treat deep caries and dental pulp infection. This procedure however,… (more)

▼ Over 15 million root canal treatments (RCT) are performed yearly in the United States to treat deep caries and dental pulp infection. This procedure however, removes both the diseased and healthy pulp, leading to tooth devitalization. Furthermore, RCTs are associated with a high incidence of re-infection and dentin fracture, reduced sensitivity and eventual tooth loss. Thus there is an unmet clinical need for alternative endodontic therapies that can preserve tooth vitality and ensure long term dental health. The strategy of vital endodontic therapy explored in this thesis centers on the design of a bioactive scaffold that guides host cell homing while providing antibiotic release, in effect harnessing the intrinsic repair potential of the native pulp while simultaneously eliminating residual bacteria that can cause recurrent infection. Specifically, a bioactive polyethylene glycol fibrinogen (PEG-fibrinogen) hydrogel is optimized to support host cell infiltration, maintain dental pulp cell phenotype, and enable pulp regeneration. Ciprofloxacin, a clinically relevant antibiotic for RCT, is incorporated into PEG-fibrinogen to prevent infection. The scaffold and culturing parameters optimized in vitro using either explant or a tooth slice model includes fibrinogen, poly(ethylene glycol) diacrylate (PEGDA) and photoinitiator concentration, as well as cell source and density. In addition, dose-dependent antibiotic effects on both anaerobic bacteria isolated from deep caries and healthy pulp cells are evaluated. The collective findings of this thesis demonstrate that a cell-instructive hydrogel comprised of a fibrinogen backbone and cross-linked with difunctional poly(ethylene glycol) side chains supports pulp cell viability, phenotypic morphology, and host cell migration. Furthermore, increasing pulp cell density promotes cell biosynthesis and a higher fibrinogen concentration is found to enhance collagen deposition. Photoinitiator and PEGDA concentrations have been optimized to enhance hydrogel mechanical properties and gel degradation, while supporting pulp cell phenotype. An optimal antibiotic dosage in the hydrogel has been identified that significantly reduces bacteria count from infected dental pulp without harmful side effects on dental pulp cell phenotype and host cell migration. In summary, this thesis focuses on the design of a bioactive hydrogel-based scaffold with antibiotic release that can induce dental pulp regeneration without the addition of cells and stimuli such as growth factors and minimize post-therapy infection. The innovative scaffold design strategy presented here lays the foundation for the development of vital endodontic therapy that harnesses pulp self-repair and sustains long-term tooth function.

Subjects/Keywords: Dental pulp cavity; Root canal therapy; Colloids in medicine; Biomedical materials; Endodontics; Dental pulp; Biomedical engineering; Dentistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prateepchinda, S. (2015). Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D80864CN

Chicago Manual of Style (16^th Edition):

Prateepchinda, Sagaw. “Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration.” 2015. Doctoral Dissertation, Columbia University. Accessed April 19, 2021. https://doi.org/10.7916/D80864CN.

MLA Handbook (7^th Edition):

Prateepchinda, Sagaw. “Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration.” 2015. Web. 19 Apr 2021.

Vancouver:

Prateepchinda S. Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Apr 19]. Available from: https://doi.org/10.7916/D80864CN.

Council of Science Editors:

Prateepchinda S. Bioactive Hydrogel Scaffold for Guided Dental Pulp Regeneration. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D80864CN

28. Walshe, Martin J., 1940-. Pulp reaction to anorganic bovine dentin.

Degree: 1967, IUPUI

URL: http://hdl.handle.net/1805/4136

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Indiana University-Purdue University Indianapolis (IUPUI)

A study was made to determine if heterogenous dentin, devoid of its antigenic potential, would stimulate reparative dentino-genesis in the… (more)

Subjects/Keywords: Dental Pulp Capping; Dental Pulp Test

…conservatively treating exposures of the dental pulp has long been a problem in dentistry. Early… …of the literature shows that superficial lesions of the dental pulp continue to present a… …pulp is now well documented * Temrex Cement, Interstate Dental Co., Inc., New York, N.Y… …technique 26 Pulp capped with bovine dentin (21 days) • • • • 27 4. Magnified view… …of Figure 3 27 5· Pulp capped with bovine dentin ( 42 days) • • • ·• • • • 28…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walshe, Martin J., 1. (1967). Pulp reaction to anorganic bovine dentin. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/4136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Walshe, Martin J., 1940-. “Pulp reaction to anorganic bovine dentin.” 1967. Thesis, IUPUI. Accessed April 19, 2021. http://hdl.handle.net/1805/4136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Walshe, Martin J., 1940-. “Pulp reaction to anorganic bovine dentin.” 1967. Web. 19 Apr 2021.

Vancouver:

Walshe, Martin J. 1. Pulp reaction to anorganic bovine dentin. [Internet] [Thesis]. IUPUI; 1967. [cited 2021 Apr 19]. Available from: http://hdl.handle.net/1805/4136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Walshe, Martin J. 1. Pulp reaction to anorganic bovine dentin. [Thesis]. IUPUI; 1967. Available from: http://hdl.handle.net/1805/4136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

29. Lee-Knight, C Todd. Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp.

Degree: MS, Faculty of Dentistry, 1995, University of Alberta

URL: https://era.library.ualberta.ca/files/2z10ws591

Subjects/Keywords: Dental ceramics.; Dental technology.; Dental bonding.; Dental pulp.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee-Knight, C. T. (1995). Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2z10ws591

Chicago Manual of Style (16^th Edition):

Lee-Knight, C Todd. “Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp.” 1995. Masters Thesis, University of Alberta. Accessed April 19, 2021. https://era.library.ualberta.ca/files/2z10ws591.

MLA Handbook (7^th Edition):

Lee-Knight, C Todd. “Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp.” 1995. Web. 19 Apr 2021.

Vancouver:

Lee-Knight CT. Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp. [Internet] [Masters thesis]. University of Alberta; 1995. [cited 2021 Apr 19]. Available from: https://era.library.ualberta.ca/files/2z10ws591.

Council of Science Editors:

Lee-Knight CT. Mechanical and electrothermal debonding: effect on ceramic veneers and dental pulp. [Masters Thesis]. University of Alberta; 1995. Available from: https://era.library.ualberta.ca/files/2z10ws591

Universidade do Rio Grande do Norte

30. Antunes, Fernanda Ginani. Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação .

Degree: 2013, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/17840

► Dental pulp stem cells have been widely investigated because of their ability to differentiate into both dental and non-dental cells, with potential use in therapies… (more)

▼ Dental pulp stem cells have been widely investigated because of their ability to differentiate into both dental and non-dental cells, with potential use in therapies involving tissue engineering. The technique of cell cryopreservation represents a viable alternative for the conservation of these cells, since it stops reversibly, in a controlled manner, all of cell biological functions in an ultra low temperature. The present study aimed to evaluate, using in vitro experiments, the influence of a cryopreservation protocol on the biologic acti vity of stem cells from human exfoliated deciduous teeth (SHED). Cells obtained from the pulp of three deciduous teeth on end-stage exfoliation or with indicated extraction were expanded in α-MEM culture medium supplemented with antibiotics and 15% fetal bovine serum. At second subculture (P2), a group of cells were submitted to cryopreservation for 30 days in 10% DMSO diluted in fetal bovine serum, at -80º C, while the remind cells continued under normal conditions of cell culture. Cell proliferation was evaluated in both groups (not cryopreserved or cryopreserved) by Trypan blue stain essay at intervals of 24, 48 and 72h after plating. Cell cycle analysis of SHEDs submitted or not to the cryopreservation protocol was performed in the same intervals. Events related to cell death were studied by Annexyn V and PI expression under flow cytometry at the intervals of 24 and 72h. The presence of nuclear morphological changes was evaluated by DAPI staining at 72h interval. It was observed that both groups exhibited an upward cell proliferation curve, without considerable changes in cell viability throughout the experiment. The distribution of cell in the cell cycle phasis was consistent with cell proliferation in both groups. There were no nuclear morphological damages in the end range of the experiment. therefore, it is concluded that the proposed cryopreservation protocol is efficient for storing the studied cell type, allowing its use in future experimental studies Advisors/Committee Members: Barbosa, Carlos Augusto Galvão (advisor), CPF:67269621420 (advisor), http://lattes.cnpq.br/5004397230198722 (advisor).

Subjects/Keywords: Polpa dental. Células-tronco. Criopreservação. Cultivo celular; Dental pulp. Stem cells. Cryopreservation. Cell culture

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antunes, F. G. (2013). Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/17840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antunes, Fernanda Ginani. “Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação .” 2013. Thesis, Universidade do Rio Grande do Norte. Accessed April 19, 2021. http://repositorio.ufrn.br/handle/123456789/17840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antunes, Fernanda Ginani. “Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação .” 2013. Web. 19 Apr 2021.

Vancouver:

Antunes FG. Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2013. [cited 2021 Apr 19]. Available from: http://repositorio.ufrn.br/handle/123456789/17840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antunes FG. Atividade biológica de células-tronco da polpa de dentes decíduos humanos submetidas à criopreservação . [Thesis]. Universidade do Rio Grande do Norte; 2013. Available from: http://repositorio.ufrn.br/handle/123456789/17840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations