subject:(Dense Core Vesicles)

1. Persoon, Claudia Marjolein. Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms.

Degree: 2021, NARCIS

URL: https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; e3705635-061b-4fac-9228-f40a54550066 ; 1871.1/e3705635-061b-4fac-9228-f40a54550066 ; urn:isbn:9789464162622 ; urn:isbn:9789464162622 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066

► Our brain consists of a complex network of neurons which communicate by secreting signaling molecules as neurotransmitters and neuromodulators. For fast communication, neurotransmitters are released… (more)

▼ Our brain consists of a complex network of neurons which communicate by secreting signaling molecules as neurotransmitters and neuromodulators. For fast communication, neurotransmitters are released by synaptic vesicles (SVs) at the contact points between neurons, the synapses. Neuromodulators are secreted by dense-core vesicles (DCVs) to regulate processes such as development, circadian rhythm, metabolism, behavior and emotions. Defects in neuromodulator signaling result in brain disorders as depression, schizophrenia, autism or obesity, but how neuromodulators are released by neurons is largely unknown. The general aim of this thesis was to characterize the mechanism of neuromodulator secretion by DCVs. We have determined the number, location and release characteristics of DCVs in neurons. Furthermore, we show that two proteins, RAB3 and RIM proteins, are essential for DCV fusion. Finally, we identified two new proteins present on DCVs and developed new tools to study DCVs in the future. The fundamental knowledge and new methods provided in this thesis will contribute to new directions for treatments of disorders related to neuromodulator signaling. Mammalian neurons contain a large number of DCVs, ranging from 1,400-18,000 per neuron, which are distributed equally throughout the neuron. DCV fusion, like SV fusion, is triggered by calcium influx but requires more prolonged repetitive stimulation to release only a small fraction. While SV fusion mechanisms have been extensively studied, providing a molecular framework of proteins organizing the release of neurotransmitters, much less is known about proteins that regulate neuromodulator secretion. We now show that RIM proteins are indispensable organizers of DCV fusion by positioning the active zone protein MUNC13 and interacting with DCVs via RAB3. Together, these data identified an essential mechanism that brings DCVs to their release site for fusion. The identification of the essential function of RAB3 in DCV fusion resolved a longstanding question in the field. In 1980, a breakthrough study by Novick and Schekman identified SEC4, the yeast RAB3, as one of the essential proteins required for fusion. Many of the proteins they identified have been shown to be essential for SV fusion in the mammalian brain, but surprisingly, RAB3 proteins are not required for SV fusion. However, removal of all RAB3 proteins is lethal for mice, suggesting RAB3 proteins had an unidentified important function. Our data now shows that RAB3 is an indispensableregulator of DCV fusion. The crucial role of RAB3 in DCV fusion shows the first distinct feature between DCV and SV fusion, and provides new explanations for the multiple, severe problems in mice which lack RAB3. This thesis contributes with fundamental insights into different aspects of neuromodulator secretion, but we currently do not have a consistent overview of what is on and inside a DCV. Therefore, we developed a new approach to isolate intact DCVs from neurons. This approach could be used for future studies to determine the… Advisors/Committee Members: Verhage, M, Toonen, RFG.

Subjects/Keywords: Neuropeptides; dense-core vesicles; secretion

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APA (6^th Edition):

Persoon, C. M. (2021). Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; e3705635-061b-4fac-9228-f40a54550066 ; 1871.1/e3705635-061b-4fac-9228-f40a54550066 ; urn:isbn:9789464162622 ; urn:isbn:9789464162622 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066

Chicago Manual of Style (16^th Edition):

Persoon, Claudia Marjolein. “Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms.” 2021. Doctoral Dissertation, NARCIS. Accessed April 13, 2021. https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; e3705635-061b-4fac-9228-f40a54550066 ; 1871.1/e3705635-061b-4fac-9228-f40a54550066 ; urn:isbn:9789464162622 ; urn:isbn:9789464162622 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066.

MLA Handbook (7^th Edition):

Persoon, Claudia Marjolein. “Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms.” 2021. Web. 13 Apr 2021.

Vancouver:

Persoon CM. Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms. [Internet] [Doctoral dissertation]. NARCIS; 2021. [cited 2021 Apr 13]. Available from: https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; e3705635-061b-4fac-9228-f40a54550066 ; 1871.1/e3705635-061b-4fac-9228-f40a54550066 ; urn:isbn:9789464162622 ; urn:isbn:9789464162622 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066.

Council of Science Editors:

Persoon CM. Neuropeptide secretion principles: Vesicle populations, characteristics and fusion mechanisms. [Doctoral Dissertation]. NARCIS; 2021. Available from: https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; e3705635-061b-4fac-9228-f40a54550066 ; 1871.1/e3705635-061b-4fac-9228-f40a54550066 ; urn:isbn:9789464162622 ; urn:isbn:9789464162622 ; urn:nbn:nl:ui:31-e3705635-061b-4fac-9228-f40a54550066 ; https://research.vu.nl/en/publications/e3705635-061b-4fac-9228-f40a54550066

2. Farina, M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons.

Degree: 2017, NARCIS

URL: https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; 87385327-83c8-4616-abea-6eaeca496f98 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98

Subjects/Keywords: Dense core vesicles; neuropeptides; regulated secretion; hippocampus; neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farina, M. (2017). Trafficking and secretion of neuropeptides in mouse hippocampal neurons. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; 87385327-83c8-4616-abea-6eaeca496f98 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98

Chicago Manual of Style (16^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons.” 2017. Doctoral Dissertation, NARCIS. Accessed April 13, 2021. https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; 87385327-83c8-4616-abea-6eaeca496f98 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98.

MLA Handbook (7^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons.” 2017. Web. 13 Apr 2021.

Vancouver:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons. [Internet] [Doctoral dissertation]. NARCIS; 2017. [cited 2021 Apr 13]. Available from: https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; 87385327-83c8-4616-abea-6eaeca496f98 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98.

Council of Science Editors:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons. [Doctoral Dissertation]. NARCIS; 2017. Available from: https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; 87385327-83c8-4616-abea-6eaeca496f98 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-87385327-83c8-4616-abea-6eaeca496f98 ; https://research.vumc.nl/en/publications/87385327-83c8-4616-abea-6eaeca496f98

3. Farina, M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons .

Degree: 2017, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/55299

Subjects/Keywords: Dense core vesicles; neuropeptides; regulated secretion; hippocampus; neurons

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farina, M. (2017). Trafficking and secretion of neuropeptides in mouse hippocampal neurons . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/55299

Chicago Manual of Style (16^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons .” 2017. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed April 13, 2021. http://hdl.handle.net/1871/55299.

MLA Handbook (7^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons .” 2017. Web. 13 Apr 2021.

Vancouver:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1871/55299.

Council of Science Editors:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2017. Available from: http://hdl.handle.net/1871/55299

4. Farina, M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons.

Degree: 2017, NARCIS

URL: https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; urn:nbn:nl:ui:31-1871/55299 ; cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; 1871/55299 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-1871/55299 ; https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9

Subjects/Keywords: Dense core vesicles; neuropeptides; regulated secretion; hippocampus; neurons

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farina, M. (2017). Trafficking and secretion of neuropeptides in mouse hippocampal neurons. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; urn:nbn:nl:ui:31-1871/55299 ; cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; 1871/55299 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-1871/55299 ; https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9

Chicago Manual of Style (16^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons.” 2017. Doctoral Dissertation, NARCIS. Accessed April 13, 2021. https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; urn:nbn:nl:ui:31-1871/55299 ; cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; 1871/55299 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-1871/55299 ; https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9.

MLA Handbook (7^th Edition):

Farina, M. “Trafficking and secretion of neuropeptides in mouse hippocampal neurons.” 2017. Web. 13 Apr 2021.

Vancouver:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons. [Internet] [Doctoral dissertation]. NARCIS; 2017. [cited 2021 Apr 13]. Available from: https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; urn:nbn:nl:ui:31-1871/55299 ; cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; 1871/55299 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-1871/55299 ; https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9.

Council of Science Editors:

Farina M. Trafficking and secretion of neuropeptides in mouse hippocampal neurons. [Doctoral Dissertation]. NARCIS; 2017. Available from: https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; urn:nbn:nl:ui:31-1871/55299 ; cba86647-7c76-4fd4-b77e-6b3ce0a061b9 ; 1871/55299 ; urn:isbn:9789462995642 ; urn:nbn:nl:ui:31-1871/55299 ; https://research.vu.nl/en/publications/cba86647-7c76-4fd4-b77e-6b3ce0a061b9

5. Keimpema, L. van. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons .

Degree: 2019, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/56012

Subjects/Keywords: neuroscience; cell biology; dense core vesicles; synapse; SNARE proteins; CAPS proteins; development

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keimpema, L. v. (2019). Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/56012

Chicago Manual of Style (16^th Edition):

Keimpema, L van. “Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons .” 2019. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed April 13, 2021. http://hdl.handle.net/1871/56012.

MLA Handbook (7^th Edition):

Keimpema, L van. “Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons .” 2019. Web. 13 Apr 2021.

Vancouver:

Keimpema Lv. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2019. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1871/56012.

Council of Science Editors:

Keimpema Lv. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2019. Available from: http://hdl.handle.net/1871/56012

University of Illinois – Urbana-Champaign

6. Maki, Agatha. Analyzing peptide release using mass spectrometry.

Degree: PhD, 0323, 2014, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/49662

► Neuropeptides are cell-to-cell signaling molecules that act as neurotransmitters, neuromodulators and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to… (more)

▼ Neuropeptides are cell-to-cell signaling molecules that act as neurotransmitters, neuromodulators and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While many peptides can be detected in a tissue homogenate, these will include processing intermediates and even protein degradation products. It is of great interest in the field of peptidomics to focus on functional characterization of proteins products such as cell-to-cell signaling peptides that are released from specific neuronal tissues, whether a brain region or specific cell. A variety of analytical techniques have emerged over the years to analyze neuropeptide release, and these methods have enabled scientists to characterize thousands of brain peptides. The focus of this research was on using various sampling approaches coupled to matrix-assisted laser desorption/ionization-mass spectrometry (MALDI MS) to analyze neuropeptide release from rodent brains. Chapter 2 is a general overview of the current state of analytical methods used to characterize neuropeptide release from cells to animals. Chapter 3 highlights two methods demonstrating neuropeptide release in a mouse model of fragile X syndrome. Sampling techniques using synaptoneurosomes and ex vivo brain slices were used to show a neuropeptide release deficit in Fmr1 KO mice. Chapter 4 highlights an approach utilizing in vivo microdialysis coupled to offline MALDI MS. This method was used to characterize extracellular peptide release from the hippocampus of rats in response to saline or morphine injection coupled with a spontaneous alternation task. In particular, fibrinopeptide A, a peptide derived from the fibrinogen α-chain, was significantly upregulated in rats exposed to morphine and spontaneous alternation testing. The functional consequence of fibronopeptide A release is still under investigation. The advancement of such analytical approaches to characterize neuropeptide release from a variety of samples ranging from cells to animals enables new discovery efforts for understanding the physiological and behavioral role of unknown peptides. Advisors/Committee Members: Sweedler, Jonathan V. (advisor), Sweedler, Jonathan V. (Committee Chair), Gillette, Martha U. (committee member), Ceman, Stephanie S. (committee member), Galvez, Roberto (committee member).

Subjects/Keywords: Peptides; Neuropeptides; Peptide Release; Mass Spectrometry; Fragile X Syndrome; Synaptoneurosomes; Brain Slices; Rab3A; Dense-Core Vesicles; Morphine; In Vivo Microdialysis; Hippocampus; Fibrinogen; Fibrinogen-α Chain Peptides; Fibrinopeptide A.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maki, A. (2014). Analyzing peptide release using mass spectrometry. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/49662

Chicago Manual of Style (16^th Edition):

Maki, Agatha. “Analyzing peptide release using mass spectrometry.” 2014. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed April 13, 2021. http://hdl.handle.net/2142/49662.

MLA Handbook (7^th Edition):

Maki, Agatha. “Analyzing peptide release using mass spectrometry.” 2014. Web. 13 Apr 2021.

Vancouver:

Maki A. Analyzing peptide release using mass spectrometry. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2014. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2142/49662.

Council of Science Editors:

Maki A. Analyzing peptide release using mass spectrometry. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2014. Available from: http://hdl.handle.net/2142/49662

7. van Keimpema, L. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons.

Degree: 2019, NARCIS

URL: https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def ; urn:nbn:nl:ui:31-1871/56012 ; b7d0110b-158b-4d1a-b548-3444385a1def ; 1871/56012 ; urn:isbn:9789402814118 ; urn:nbn:nl:ui:31-1871/56012 ; https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def

Subjects/Keywords: CAPS proteins; SNARE proteins; cell biology; dense core vesicles; development; neuroscience; synapse

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Keimpema, L. (2019). Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def ; urn:nbn:nl:ui:31-1871/56012 ; b7d0110b-158b-4d1a-b548-3444385a1def ; 1871/56012 ; urn:isbn:9789402814118 ; urn:nbn:nl:ui:31-1871/56012 ; https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def

Chicago Manual of Style (16^th Edition):

van Keimpema, L. “Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons.” 2019. Doctoral Dissertation, NARCIS. Accessed April 13, 2021. https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def ; urn:nbn:nl:ui:31-1871/56012 ; b7d0110b-158b-4d1a-b548-3444385a1def ; 1871/56012 ; urn:isbn:9789402814118 ; urn:nbn:nl:ui:31-1871/56012 ; https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def.

MLA Handbook (7^th Edition):

van Keimpema, L. “Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons.” 2019. Web. 13 Apr 2021.

Vancouver:

van Keimpema L. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons. [Internet] [Doctoral dissertation]. NARCIS; 2019. [cited 2021 Apr 13]. Available from: https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def ; urn:nbn:nl:ui:31-1871/56012 ; b7d0110b-158b-4d1a-b548-3444385a1def ; 1871/56012 ; urn:isbn:9789402814118 ; urn:nbn:nl:ui:31-1871/56012 ; https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def.

Council of Science Editors:

van Keimpema L. Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons. [Doctoral Dissertation]. NARCIS; 2019. Available from: https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def ; urn:nbn:nl:ui:31-1871/56012 ; b7d0110b-158b-4d1a-b548-3444385a1def ; 1871/56012 ; urn:isbn:9789402814118 ; urn:nbn:nl:ui:31-1871/56012 ; https://research.vu.nl/en/publications/b7d0110b-158b-4d1a-b548-3444385a1def

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