subject:(Dendrites)

Rutgers University

1. Hernandez, Kristina, 1985-. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.

Degree: PhD, Cell and Developmental Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

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Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several… (more)

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Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several neurodevelopmental disorders that are characterized by alterations in dendrite branching and spine density. NOS1AP is a protein encoded by a schizophrenia susceptibility gene, and its expression is upregulated in the dorsolateral prefrontal cortex of patients with schizophrenia. Previously, our laboratory showed that NOS1AP isoforms negatively regulate dendrite branching in cultured rat hippocampal neurons. Since dendrites and spines are influenced by changes in the cytoskeleton, we investigated whether the overexpression of NOS1AP isoforms in heterologous cells alters actin and microtubule organization. Overexpression of a long isoform of NOS1AP (NOS1AP-L) increases the presence of microtubule organizing centers, whereas overexpression of the short isoform of NOS1AP (NOS1AP-S) decreases microtubule organization. Furthermore, NOS1AP isoforms associate with F-actin in rat brain and can alter actin organization in distinct ways. NOS1AP-S increases actin polymerization, and its overexpression in HEK293T cells decreases total Rac1 and cofilin protein expression. To elucidate the role of NOS1AP in spine formation and synaptic function, we overexpressed NOS1AP isoforms in cultured rat cortical neurons. Overexpression of NOS1AP-L increases the number of immature spines, whereas overexpression of NOS1AP-S increases the number of mature and immature spines. In addition, overexpression of NOS1AP-S increases the frequency of miniature excitatory postsynaptic currents (mEPSCs) but not the amplitude. Overexpression of NOS1AP-L decreases the amplitude of mEPSCs but not the frequency. To investigate whether NOS1AP-L can mediate changes to dendrite patterning in vivo, we overexpressed NOS1AP-L in neuronal progenitor cells of the embryonic rat neocortex and analyzed dendrite patterning three weeks later. Neurons overexpressing NOS1AP-L in layers II/III of the neocortex exhibit a reduction in dendrite length and number. Finally, to investigate the role that NOS1AP plays in human dendritic arbor development, human neurons were generated using induced pluripotent stem cell technology. Overexpression of either NOS1AP-L or NOS1AP-S in human neurons results in a decrease in dendrite branching. Interestingly, treatment of human neurons with D-serine results in a reduction in NOS1AP-L protein expression. Taken together, our data support a role for NOS1AP-L and NOS1AP-S in dendritogenesis and synaptic function.

Advisors/Committee Members: Firestein, Bonnie L. (chair), Tischfield, Jay A. (internal member), Moore, Jennifer C. (internal member), Hart, Ronald P. (internal member), Brzustowicz, Linda M. (internal member), Silverstein, Steve (outside member).

Subjects/Keywords: Schizophrenia; Dendrites

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APA (6^th Edition):

Hernandez, Kristina, 1. (2015). The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

Chicago Manual of Style (16^th Edition):

Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Doctoral Dissertation, Rutgers University. Accessed October 15, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.

MLA Handbook (7^th Edition):

Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Web. 15 Oct 2019.

Vancouver:

Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2019 Oct 15]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.

Council of Science Editors:

Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

Rutgers University

2. Patel, Mihir V., 1987-. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.

Degree: PhD, Neuroscience, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

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Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its… (more)

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Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its interactor, cytosolic PSD-95 interactor (cypin), regulate dendrite branching by altering microtubule dynamics. Additionally, other PSD-95 binding proteins, end-binding protein 3 (EB3) and adenomatous polyposis coli (APC), promote microtubule bundling and stabilization. Thus, PSD-95 and binding partners may regulate the dendritic arbor during development and after injury. I first addressed the role of cypin in the brain in vivo. While generating cypin knockout mice, I identified a novel short isoform of cypin, termed cypinS, which also binds to PSD-95 and regulates dendrite branching, although an increase in dendrites occur more distal from the soma when cypinS is overexpressed compared to when cypin is overexpressed. In addition, unlike cypin, cypinS does not have guanine deaminase activity. Overexpression of cypin, but not cypinS, decreases spine density, suggestingiv that the regulation of spine density but not dendrite branching by cypin is dependent on guanine deaminase activity. Furthermore, I have uncovered novel presynaptic roles for both isoforms as overexpression of either isoform leads to increases in miniature excitatory postsynaptic current (mEPSC) frequency. Thus, cypin and cypinS, play distinct roles in neuronal development. I then chose to study the roles of PSD-95 and interactors in recovery after traumatic brain injury (TBI). We previously identified cypin as a novel target for TBI, and thus, here I studied the role of PSD-95 and its interaction with APC or EB3 in after injury induced by in vitro and in vivo models of TBI. I show that our in vitro model of mechanical stretch injury mimics moderate injury induced by controlled cortical impact (CCI) in mice. During the early stage (1-7 days) post-moderate CCI, the interaction of PSD-95 with APC and EB3 increases. Furthermore, downregulation of PSD-95 prevents stretch-injury mediated decreases in secondary dendrite number and total dendrite length, suggesting a required role of PSD-95 in injury-mediated insults to dendrites. Thus, PSD-95 may sequester APC and EB3 from microtubules to cause decreases in dendrite branching after TBI, and PSD-95 can be targeted as a novel approach for the treatment of patients with TBI.

Advisors/Committee Members: Firestein, Bonnie L (chair), Shumyatsky, Gleb (internal member), Alder, Janet (internal member), D’Arcangelo, Gabriella (internal member), Runnels, Loren (outside member), School of Graduate Studies.

Subjects/Keywords: Dendrites; Brain damage

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APA (6^th Edition):

Patel, Mihir V., 1. (2018). The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Chicago Manual of Style (16^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Doctoral Dissertation, Rutgers University. Accessed October 15, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

MLA Handbook (7^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Web. 15 Oct 2019.

Vancouver:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2019 Oct 15]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

Council of Science Editors:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Rutgers University

3. Peng, Sheng-Shiang. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.

Degree: MS, Biology, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

► The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance… (more)

▼ The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance molecules and receptors control the majority of the circuitry events, including promotion or inhibition of neurite growth. Semphorin 3A, a secreted Class 3 Semaphorin member, is well known for its chemorepellent function on growth cone mediated by the Neuropilin1/PlexinA4 holoreceptor complex. Recently, it has been shown to have opposite cellular responses in promoting dendrite growth and branching in mouse cortical pyramidal neurons (1, 2). However, the mechanism underlying how Semaphorin 3A/Neuropilin1/Plexin-A4 signaling regulates dendrite elaboration is unclear. Here, I have shown the importance and function of three distinct domains in the cytoplasmic region of the signaling transducing receptor of Semaphorin 3A, Plexin-A4, in regulating cortical neuron dendritic morphology. Both the C1 and H/RBD domains were found to be sufficient to trigger cortical pyramidal neuron dendrite elaboration, while the C2 domain was not necessary for dendrites growth and branching. Using biochemical and molecular methods in combination with in vitro assays, I found and demonstrated that the Rho-GEF, FARP2 associates with PlexinA4 and mediates dendritic elaboration in primary cortical neurons following the ligand, Semaphorin 3A activation of the signaling pathway. In addition, I demonstrated that Plexin-A4 extracellular domains could interact with its co-receptor Neuropilin1, independent of the ligand Semaphorin 3A. Therefore, the extracellular Semaphorin domain may play a role in preventing Plexin-A4 activation, consistent with previous studies (3, 4). Previously, another member of the Type A Plexin receptor, Plexin-A3, was shown to play a key role in inhibiting cortical neuron dendritic spine morphogenesis in vivo (2). However, the mechanism of how Plexin-A3 signals to restrain spine formation is unknown. I have generated an array of Plexin-A3 cytoplasmic deletion mutant constructs, analogous to the Plexin-A4 deletion mutants used for this study for future studies in investigating cortical neuron dendritic spine morphology. These molecular tools that I have developed will be useful for researchers to investigate the intracellular signaling mechanisms of Semaphorin signaling in regulating neuron morphology. Taken together, my findings provide new insights to Plexin-A4 signaling, in particular, highlighting distinct intracellular domains and downstream effectors required for promoting dendritic morphology. Advisors/Committee Members: Tran, Tracy (chair), Haspel, Gal (internal member), Maurel, Patrice (internal member).

Subjects/Keywords: Neurons – Growth; Semaphorins; Dendrites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peng, S. (2014). Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

Chicago Manual of Style (16^th Edition):

Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Masters Thesis, Rutgers University. Accessed October 15, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.

MLA Handbook (7^th Edition):

Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Web. 15 Oct 2019.

Vancouver:

Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Internet] [Masters thesis]. Rutgers University; 2014. [cited 2019 Oct 15]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.

Council of Science Editors:

Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Masters Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

Rutgers University

4. Sweet, Eric S. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.

Degree: Neuroscience, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Subjects/Keywords: Microtubules; Dendrites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sweet, E. S. (2011). To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Thesis, Rutgers University. Accessed October 15, 2019. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Web. 15 Oct 2019.

Vancouver:

Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Internet] [Thesis]. Rutgers University; 2011. [cited 2019 Oct 15]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Thesis]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

5. DiPietro, Joseph V. The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence .

Degree: 2017, Cornell University

URL: http://hdl.handle.net/1813/56717

► The work presented in this dissertation is an in-depth analysis of how a single neuron, the primary motoneuron of zebrafish, searches for and forms synapses… (more)

▼ The work presented in this dissertation is an in-depth analysis of how a single neuron, the primary motoneuron of zebrafish, searches for and forms synapses across the circadian periods of activity and quiescence that occur from day to night. Dendrites repeatedly extend and retract filopodia in a search for synapses, the formation of which stabilizes the process, leading to growth of the arbor. I first focused my attention on zebrafish primary neurons during the day to explore, for the first time, the search process from the level of individual filopodial dynamics to the distribution of dynamics across an entire dendritic arbor. We found the magnitude of searching at individual locations varied tremendously across locations, with filopodia extending and retracting as much as 3 microns and averaging about 12 dynamics events per filopodium in a given 30-minute period. An analysis of the temporal sequence of these dynamic events showed the pattern of dynamics at individual locations also varied tremendously. Only retractions showed a consistent trend, tending to stabilize for some time and rarely being followed by an extension. This shows that dendrites are not just simply extending and stabilizing filopodia. Instead, filopodia at each individual location are engaging in highly dynamic periods of searching, with most extensions retracting within 5 minutes. Only about 4% of extensions survive for an hour or more, possibly representing the formation of synapses. We further find that these dynamic locations are equally distributed across the dendrite arbor independent of their individual dynamics and only the furthest extents of dendrite had higher than average numbers of motile locations, suggesting the search is largely unbiased except for those furthest regions. A comparison of how the search differs between day and night shows surprisingly, that the magnitude of this searching increases at night, a quiescent time, when motoneuron are much less active. While the extensions at night are less likely to stabilize, this increase in searching may partly account for these cells still forming synapses at a similar rate as during the day, with only the rate of synapse removal changing, increasing significantly at night. These results demonstrate that during times of behavioral and activity quiescence, neurons continue to search for and form synapses at the expense of losing others, providing potential insight into the role these quiescent states may play in network development and neuronal plasticity. Advisors/Committee Members: Harris-Warrick, Ronald Morgan (committeeMember), Bass, Andrew Howard (committeeMember), Schaffer, Chris (committeeMember).

Subjects/Keywords: dendrites; motoneurons; sleep; synapses; zebrafish; Development; Neurosciences

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APA (6^th Edition):

DiPietro, J. V. (2017). The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/56717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DiPietro, Joseph V. “The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence .” 2017. Thesis, Cornell University. Accessed October 15, 2019. http://hdl.handle.net/1813/56717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DiPietro, Joseph V. “The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence .” 2017. Web. 15 Oct 2019.

Vancouver:

DiPietro JV. The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence . [Internet] [Thesis]. Cornell University; 2017. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1813/56717.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DiPietro JV. The Search for and Formation of Synapses on Zebrafish Motoneurons Across Natural Periods of Activity and Quiescence . [Thesis]. Cornell University; 2017. Available from: http://hdl.handle.net/1813/56717

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

6. Croydon, David Alexander. Random fractal dendrites.

Degree: 2006, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:4e17aebc-456d-4891-8527-692331ebff05 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440154

► Dendrites are tree-like topological spaces, and in this thesis, the physical characteristics of various random fractal versions of this type of set are investigated. This… (more)

▼ Dendrites are tree-like topological spaces, and in this thesis, the physical characteristics of various random fractal versions of this type of set are investigated. This work will contribute to the development of analysis on fractals, an area which has grown considerably over the last twenty years. First, a collection of random self-similar dendrites is constructed, and their Hausdorff dimension is calculated. Previous results determining this quantity for random self-similar structures have often relied on the scaling factors being bounded uniformly away from zero. However, using a percolative argument, and taking advantage of the tree-like structure of the sets considered here, it is shown that this condition is not necessary; a simple condition on the tail of the distribution of the scaling factors at zero is all that is assumed. The scaling factors of these recursively defined structures form what is known as a multiplicative cascade, and results about the height of this random object are also obtained. With important physical and probabilistic applications, the heat equation has justifiably received a substantial amount of attention in a variety of settings. For certain types of fractals, it has become clear that a key factor in estimating the heat kernel is the volume growth with respect to the resistance metric on the space. In particular, uniform polynomial volume growth, which occurs for many deterministic self-similar fractals, immediately implies uniform (on-diagonal) heat kernel behaviour. However, in the random fractal setting, this is frequently not the case, and volume fluctuations are often observed. Motivated by this, an analysis of how volume fluctuations lead to corresponding heat kernel fluctuations for measure-metric spaces equipped with a resistance form is conducted here. These results apply to the aforementioned random self-similar dendrites, amongst other examples. The continuum random tree (CRT) of Aldous is an important random example of a measure-metric space, and fits naturally into the framework of the previous paragraph. In this thesis, quenched (almost-sure) volume growth asymptotics for the CRT are deduced, which show that the behaviour in almost-every realisation is not uniform. Applying the results introduced above, these yield heat kernel bounds for the CRT, demonstrating that heat kernel fluctuations occur almost-surely. Finally, a new representation of the CRT as a random self-similar dendrite is presented.

Subjects/Keywords: 514.742; Dendrites : Mathematical models : Fractals : Topological spaces

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Croydon, D. A. (2006). Random fractal dendrites. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:4e17aebc-456d-4891-8527-692331ebff05 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440154

Chicago Manual of Style (16^th Edition):

Croydon, David Alexander. “Random fractal dendrites.” 2006. Doctoral Dissertation, University of Oxford. Accessed October 15, 2019. http://ora.ox.ac.uk/objects/uuid:4e17aebc-456d-4891-8527-692331ebff05 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440154.

MLA Handbook (7^th Edition):

Croydon, David Alexander. “Random fractal dendrites.” 2006. Web. 15 Oct 2019.

Vancouver:

Croydon DA. Random fractal dendrites. [Internet] [Doctoral dissertation]. University of Oxford; 2006. [cited 2019 Oct 15]. Available from: http://ora.ox.ac.uk/objects/uuid:4e17aebc-456d-4891-8527-692331ebff05 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440154.

Council of Science Editors:

Croydon DA. Random fractal dendrites. [Doctoral Dissertation]. University of Oxford; 2006. Available from: http://ora.ox.ac.uk/objects/uuid:4e17aebc-456d-4891-8527-692331ebff05 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440154

Baylor University

7. Hamilton, Brent (Brent A.). Asymptotic arc-components in inverse limits of dendrites.

Degree: Mathematics., 2011, Baylor University

URL: http://hdl.handle.net/2104/8216

► We study asymptotic behavior arising in inverse limit spaces of dendrites. In particular, the inverse limit is constructed with a single unimodal bonding map, for… (more)

Subjects/Keywords: Topology.; Continuum theory.; Inverse limits.; Dendrites.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamilton, B. (. A. ). (2011). Asymptotic arc-components in inverse limits of dendrites. (Thesis). Baylor University. Retrieved from http://hdl.handle.net/2104/8216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites. ” 2011. Thesis, Baylor University. Accessed October 15, 2019. http://hdl.handle.net/2104/8216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites. ” 2011. Web. 15 Oct 2019.

Vancouver:

Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Internet] [Thesis]. Baylor University; 2011. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/2104/8216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Thesis]. Baylor University; 2011. Available from: http://hdl.handle.net/2104/8216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

8. Burgess, JoColl Alexis. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.

Degree: MS, Anatomy & Neurobiology, 2018, Boston University

URL: http://hdl.handle.net/2144/31219

► Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of… (more)

▼ Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of the brain. Structural and morphological changes in cellular alignment in the minicolumns correlate with increased prevalence of neurological diseases and in aging. In the rhesus monkey, cognitive decline is similar to what humans experience in aging. In the monkey prefrontal cortex, Brodmann area 46, an important region for executive functioning, cognitive decline correlates with changes in cellular alignment or “columnar strength” as studies by Cruz et al., (2009). Using the density maps method in Area 46, the ventral bank was identified to be the most susceptible to structural changes. Minicolumns, are defined by the cellular alignment of neurons in the cortex and some believe that the dendritic bundles of neurons in the cortex is also considered an integral part of the columns. The functional role of apical dendrites, is not well understood, however, given the that repeated organized bundles transverse through the laminae could be further support for their inclusion in minicolumns with possible functional importance. If structural changes such as loss of columnar strength (neuronal displacement) that correlates with cognitive aging, it is possible that the dendritic organization may also be affected in this area. In this thesis, it is hypothesized that the dendritic bundles in this area could also be related to the cognitive deficits associated with normal aging. Using double- fluorescence labeling for dendrites (MAP-2) and neurons (Neu-N), 3D confocal reconstructions of the dorsal and ventral banks of Area 46 were used to investigate structural/morphological changes in the dendritic bundles in young and old rhesus monkeys. While cortical thickness and apical dendritic length between both banks did not change, we found a significant increase in inter-bundle spacing at layer 6A in the older monkeys in the ventral bank. Inter-bundle spacing for bundles in layer 5 was measured and showed that the young consistently have smaller inter-bundle spacing. Future studies with larger sample size will also investigate whether changes in dendritic bundles and their organization also correlate with age-related cognitive deficits. Advisors/Committee Members: Zumwalt, Ann C. (advisor).

Subjects/Keywords: Neurosciences; Minicolumns; Monkeys; Area 46; Apical dendrites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burgess, J. A. (2018). 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/31219

Chicago Manual of Style (16^th Edition):

Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Masters Thesis, Boston University. Accessed October 15, 2019. http://hdl.handle.net/2144/31219.

MLA Handbook (7^th Edition):

Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Web. 15 Oct 2019.

Vancouver:

Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Internet] [Masters thesis]. Boston University; 2018. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/2144/31219.

Council of Science Editors:

Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/31219

Delft University of Technology

9. Mul, M.M. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:.

Degree: 2014, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

► A three-dimensional mixed-mode cellular automaton model [C. Bos, M. G. Mecozzi, and J. Sietsma. Computational Materials Science 48.3 (2010): 692-699] for the austenite to ferrite… (more)

Subjects/Keywords: phase transformation; cellular automaton; steel alloy; dendrites

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APA (6^th Edition):

Mul, M. M. (2014). Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

Chicago Manual of Style (16^th Edition):

Mul, M M. “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:.” 2014. Masters Thesis, Delft University of Technology. Accessed October 15, 2019. http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.

MLA Handbook (7^th Edition):

Mul, M M. “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:.” 2014. Web. 15 Oct 2019.

Vancouver:

Mul MM. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:. [Internet] [Masters thesis]. Delft University of Technology; 2014. [cited 2019 Oct 15]. Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.

Council of Science Editors:

Mul MM. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability:. [Masters Thesis]. Delft University of Technology; 2014. Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

University of Edinburgh

10. Ikpegbu, Ekele. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.

Degree: PhD, 2018, University of Edinburgh

URL: http://hdl.handle.net/1842/31361

► Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In… (more)

▼ Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In cartilage, FGF-2 regulates E11/podoplanin expression in murine joints following surgical destabilisation (DMM model of osteoarthritis (OA)), and in cartilage explant injury models. In bone, E11 is critical for the early stages of osteocytogenesis and is responsible for the acquisition of the osteocyte dendritic phenotype. This dendritic phenotype is dysregulated in OA and given the known role of the osteocyte in controlling bone remodelling, this may contribute to the subchondral bone thickening observed in OA. Hence, the aim of this study was to elucidate the nature of FGF-2- mediated E11 expression and osteocytogenesis in skeletal health and disease. This thesis has shown that FGF-2 dose-dependently increased E11 mRNA expression in MC3T3 cells, primary osteoblasts and in primary calvaria organ cultures, which was confirmed by E11 protein western blotting data. The FGF-2 induced changes in E11 expression were accompanied by significant increases in the mRNA expression of the osteocyte markers Phex and Dmp1, and significant decreases in the mRNA expression of the osteoblast markers Col1a1, Postn, Bglap and Alpl expression. This thus supports the hypothesis that FGF-2 drives osteocytogenesis. The acquisition of osteocyte phenotype involves the re-organisation of the cytoskeleton, such as F-actin. This step is important for the transition of cuboidal-shaped osteoblasts to the stellate-shaped osteocyte phenotype. FGF-2 stimulation of MC3T3 cells and primary osteoblasts revealed more numerous and longer dendrites, as visualised by phalloidin staining for F-actin and indicative of the acquisition of the osteocyte phenotype. In contrast, control cells had a typical rounded morphology with fewer and shorter dendrites. Furthermore, immunofluorescence labelling for E11 in control cells revealed uniform distribution throughout the cytoplasm, especially in the perinuclear region. In contrast, FGF-2 treated cells showed a modified distribution where E11 was negligible in the cytoplasm, but concentrated in the dendrites. The use of siRNA knockdown of E11 achieved a 70% reduction of basal E11 mRNA expression. This knockdown also effectively abrogated FGF-2-related changes in E11 expression and dendrite formation as disclosed by mRNA and protein expression, immunofluorescence and F-actin staining with phalloidin. Despite these FGF-2 driven increases in E11 and osteocyte dendrite formation in vitro, immunohistochemical labelling revealed no differences in E11 expression in subchondral, trabecular and cortical osteocytes from naïve Fgf-2 deficient mice in comparison to wild-type mice. Similar results were observed upon sclerostin immunolabelling. FGF-2 stimulation of MC3T3 cells elicited activation of ERK1/2, Akt and p38 MAPK. However, inhibition of the aforementioned pathways failed to reduce FGF-2- mediated E11 expression and as such, the specific signalling pathway responsible…

Subjects/Keywords: osteoblasts; osteocyte; dendrites; E11; FGF-2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ikpegbu, E. (2018). Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/31361

Chicago Manual of Style (16^th Edition):

Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed October 15, 2019. http://hdl.handle.net/1842/31361.

MLA Handbook (7^th Edition):

Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Web. 15 Oct 2019.

Vancouver:

Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1842/31361.

Council of Science Editors:

Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/31361

Vrije Universiteit Amsterdam

11. Groen, M.R. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .

Degree: 2013, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/40417

Subjects/Keywords: neuroscience; dendrites; development

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APA (6^th Edition):

Groen, M. R. (2013). Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/40417

Chicago Manual of Style (16^th Edition):

Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .” 2013. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed October 15, 2019. http://hdl.handle.net/1871/40417.

MLA Handbook (7^th Edition):

Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .” 2013. Web. 15 Oct 2019.

Vancouver:

Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2013. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1871/40417.

Council of Science Editors:

Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2013. Available from: http://hdl.handle.net/1871/40417

George Mason University

12. Rubaharan, Myurajan. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .

Degree: 2014, George Mason University

URL: http://hdl.handle.net/1920/9111

► Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional nervous system. Dendrites,… (more)

▼ Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional nervous system. Dendrites, as the primary sites of synaptic and/or sensory input largely determine the size and nature of the neuronal receptive field. The Drosophila melanogaster peripheral nervous system (PNS) has emerged as an excellent model system for studying molecular mechanisms underlying class specific dendrite development. Dendritic arborization (da) neurons are grouped into four distinct classes (I- IV) based upon increasing orders of dendritic complexity (Grueber et al., 2002). A recent study has identified dar1, a Krüppel-like transcription factor, as an essential regulator involved in controlling dendrite development and growth via microtubule modulation (Ye et al., 2011). Interestingly, at the embryonic stage Dar1 protein exhibits nuclear localization in all da neuron subclasses, however at the third instar larval stage of development, Dar1 exhibits a subcellular shift towards class-specific differential localization. Specifically, Dar1 is primarily nuclear in the morphologically simple class I neurons, in contrast to largely cytoplasmic localization in the highly complex class IV da neurons. This observation led us to investigate putative protein interaction partners of Dar1 that potentially regulate this class specific differential localization, and the result of perturbing this localization. We conducted a pilot RNAi screen of putative Dar1- interacting proteins to investigate their potential mechanistic role(s) in dendrite development and Dar1 differential localization in class IV da neurons. From this pilot screen, we identified the CBP/p300 homolog nejire (nej) as a novel regulator of dendritic development that also modulates Dar1 subcellular localization. We have conducted detailed structure-function studies using domain-specific deletions of nej that have provided further insights into the specific role of different protein domains in mediating distinct aspects of dendritic growth. Furthermore, we have used these domain-specific deletion constructs to elucidate the interaction between Dar1 and Nej. Collectively, these analyses contribute to our understanding of molecular mechanisms of combinatorial transcription factor activity at a class-specific level and how this regulation contributes to specification of distinct neuronal morphologies that underlie the establishment of complex neural networks. Advisors/Committee Members: Cox, Daniel N (advisor).

Subjects/Keywords: dendrites; neuron; Drosophila; transcription factor; Nejire; Dar1

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APA (6^th Edition):

Rubaharan, M. (2014). Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/9111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .” 2014. Thesis, George Mason University. Accessed October 15, 2019. http://hdl.handle.net/1920/9111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .” 2014. Web. 15 Oct 2019.

Vancouver:

Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . [Internet] [Thesis]. George Mason University; 2014. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1920/9111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . [Thesis]. George Mason University; 2014. Available from: http://hdl.handle.net/1920/9111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

13. Brunette, Katyarina Efimenko. Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus.

Degree: PhD, Neuroscience, 2009, University of Minnesota

URL: http://purl.umn.edu/56586

► Using a dietary model in Sprague Dawley rats of gestational/neonatal iron deficiency, our lab has demonstrated structural, biochemical, electrophysiological and behavioral changes in the developing… (more)

Subjects/Keywords: Dendrites; Development; Hippocampus; Iron Deficiency; Spines; Neuroscience

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APA (6^th Edition):

Brunette, K. E. (2009). Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/56586

Chicago Manual of Style (16^th Edition):

Brunette, Katyarina Efimenko. “Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus.” 2009. Doctoral Dissertation, University of Minnesota. Accessed October 15, 2019. http://purl.umn.edu/56586.

MLA Handbook (7^th Edition):

Brunette, Katyarina Efimenko. “Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus.” 2009. Web. 15 Oct 2019.

Vancouver:

Brunette KE. Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus. [Internet] [Doctoral dissertation]. University of Minnesota; 2009. [cited 2019 Oct 15]. Available from: http://purl.umn.edu/56586.

Council of Science Editors:

Brunette KE. Early iron deficiency anemia alters structure in pyramidal neuron apical dendrites and cytoskeletal modifiers associated with dendrite development in the hippocampus. [Doctoral Dissertation]. University of Minnesota; 2009. Available from: http://purl.umn.edu/56586

University of California – San Francisco

14. Devault, Laura. Characterization of Dendrite Development and Regeneration.

Degree: Neuroscience, 2018, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/1fn3s6tx

► Despite their key role in neuronal function, current understanding of dendrite development and regeneration are lacking. We focused on the class IV dendritic arborization (c4da)… (more)

▼ Despite their key role in neuronal function, current understanding of dendrite development and regeneration are lacking. We focused on the class IV dendritic arborization (c4da) neuron of the Drosophila sensory system to address aspects of dendrite development and regeneration due to the complex dendritic arbor and peripheral location of these neurons. Although molecular motors are known to play a role in the development of the dendritic arbor, there was not a comprehensive understanding of kinesins in dendrite development. Therefore, a screen for kinesins which regulate dendritic arbor complexity was performed. Candidates for further study were identified. Aspects of dendrite development in adulthood were also examined, including the function of c4da neuron in the adult abdomen and the source of extracellular matrix in the abdomen. The focus of this work is on the ability of neurons to regenerate dendrites. This study characterizes the structural and functional capacity for dendrite regeneration in vivo in adult animals and examines the effect of neuronal maturation on dendrite regeneration. which has a dendritic arbor that undergoes dramatic remodeling during the first 3 d of adult life and then maintains a relatively stable morphology thereafter. Using a laser severing paradigm, we monitored regeneration after acute and spatially restricted injury. We found that the capacity for regeneration was present in adult neurons but diminished as the animal aged. Regenerated dendrites recovered receptive function. Furthermore, we found that the regenerated dendrites show preferential alignment with the extracellular matrix (ECM). Finally, inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration. These results demonstrate that dendrites retain regenerative potential throughout adulthood and that regenerative capacity decreases with aging.

Subjects/Keywords: Neurosciences; Dendrites; Development; Drosophila; Neuron; Regeneration

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APA (6^th Edition):

Devault, L. (2018). Characterization of Dendrite Development and Regeneration. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/1fn3s6tx

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Devault, Laura. “Characterization of Dendrite Development and Regeneration.” 2018. Thesis, University of California – San Francisco. Accessed October 15, 2019. http://www.escholarship.org/uc/item/1fn3s6tx.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Devault, Laura. “Characterization of Dendrite Development and Regeneration.” 2018. Web. 15 Oct 2019.

Vancouver:

Devault L. Characterization of Dendrite Development and Regeneration. [Internet] [Thesis]. University of California – San Francisco; 2018. [cited 2019 Oct 15]. Available from: http://www.escholarship.org/uc/item/1fn3s6tx.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Devault L. Characterization of Dendrite Development and Regeneration. [Thesis]. University of California – San Francisco; 2018. Available from: http://www.escholarship.org/uc/item/1fn3s6tx

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

15. Newby, Jay. Molecular motor-based models of random intermittent search in dendrites.

Degree: PhD, Mathematics;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

► A key component in the cellular mechanisms underlying learning and memory involves the distribution and delivery of mRNA to synaptic sites in dendrites. A minimal… (more)

Subjects/Keywords: Dendrites; Intracellular transport; Jump velocity; Molecular motors; MRNA transport; Random search

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APA (6^th Edition):

Newby, J. (2010). Molecular motor-based models of random intermittent search in dendrites. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

Chicago Manual of Style (16^th Edition):

Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Doctoral Dissertation, University of Utah. Accessed October 15, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.

MLA Handbook (7^th Edition):

Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Web. 15 Oct 2019.

Vancouver:

Newby J. Molecular motor-based models of random intermittent search in dendrites. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2019 Oct 15]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.

Council of Science Editors:

Newby J. Molecular motor-based models of random intermittent search in dendrites. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

University of Alberta

16. Kim, Hojeong. Biophysics underlying bistable neurons with branching dendrites.

Degree: PhD, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/fq977w125

► The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons.… (more)

▼ The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons. After reviewing the relevant motoneuron physiology and theories that describe complex dendritic signaling properties, I hypothesize that at least five passive electrical properties must be considered to better understand the physiological input-output properties of motor neurons in vivo: input resistance, system time constant, and three signal propagation properties between the soma and dendrites that depend on the signal direction (i.e. soma to dendrites or vice versa) and type (i.e. direct (DC) or alternating (AC) current). To test my hypothesis, I begin with characterizing the signal propagation of the dendrites, by directly measuring voltage attenuations along the path of dendrites of the type-identified anatomical neuron models. Based on this characterization of dendritic signaling, I develop the novel realistic reduced modeling approach by which the complex geometry and passive electrical properties of anatomically reconstructed dendrites can be analytically mapped into simple two-compartment modeling domain without any restrictive assumptions. Combining mathematical analysis and computer simulations of my new reduced model, I show how individual biophysical properties (system input resistance, time constant and dendritic signaling) contribute to the local excitability of the dendrites, which plays an essential role in activating the plateau generating membrane mechanisms and subsequent nonlinear input-output relations in a single neuron. The biophysical theories and computer simulations in this thesis are primarily applied to motor neurons that compose the motor neuron pool for control of movement. However, the general features of the new reduced neuron modeling approach and important insights into neuronal computations are not limited to this area. My findings can be extended to other areas including artificial neural networks consisting of single compartment processors.

Subjects/Keywords: Dendrites; Neuron; Direction dependent voltage attenuation; Reduced modeling; Bistable firing behaviour

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, H. (2011). Biophysics underlying bistable neurons with branching dendrites. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/fq977w125

Chicago Manual of Style (16^th Edition):

Kim, Hojeong. “Biophysics underlying bistable neurons with branching dendrites.” 2011. Doctoral Dissertation, University of Alberta. Accessed October 15, 2019. https://era.library.ualberta.ca/files/fq977w125.

MLA Handbook (7^th Edition):

Kim, Hojeong. “Biophysics underlying bistable neurons with branching dendrites.” 2011. Web. 15 Oct 2019.

Vancouver:

Kim H. Biophysics underlying bistable neurons with branching dendrites. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2019 Oct 15]. Available from: https://era.library.ualberta.ca/files/fq977w125.

Council of Science Editors:

Kim H. Biophysics underlying bistable neurons with branching dendrites. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/fq977w125

University of Edinburgh

17. Monteiro, Olivia F. de S. Mechanisms of dendritic peptide release.

Degree: 2010, University of Edinburgh

URL: http://hdl.handle.net/1842/4420

► Magnocellular neurones (MCNs) are capable of secreting vasopressin and oxytocin from the somato-dendritic compartment, which can occur independently to secretion from nerve terminals. One hypothesis… (more)

▼ Magnocellular neurones (MCNs) are capable of secreting vasopressin and oxytocin from the somato-dendritic compartment, which can occur independently to secretion from nerve terminals. One hypothesis of the mechanism that regulates this differential release is that dendrites utilise different vesicle pools compared to those found in terminals. Little is known for the function of neuronal dendrites, especially the mechanism for peptide release. One theory is that vesicles stored in dendrites are non-released vesicles ready for recycling or degradation. Immunofluorescent labelling was performed on hypothalamic slices of the transgenic rat where enhanced green fluorescent protein (eGFP) was tagged to vasopressin. Lysosomes were detected by the lysosome-associated membrane protein LAMP1. Correlation analysis of LAMP1 labelling and VP-eGFP had shown that localisation of lysosomes in dendrites is positively correlated to loci of high vasopressin expression. This suggests active degradation of vesicles in dendrites. It is not known whether preferential release of peptides occurs along the profile of dendrites. Experiments were carried out using a temperature block to block exit of vesicles from the Golgi apparatus. Release of the temperature block triggered release of a wave of newly synthesised vesicles from the Golgi apparatus. Measurement of the fluorescent intensity of VP-eGFP showed that preferential release of peptides does not occur along the profile of dendrites. I have also utilised confocal live cell imaging to study the dynamics of dendritic vasopressin release using VP-eGFP slice explants. Experiments using high potassium stimulation showed significant increase in the release of vasopressin after priming with thapsigargin (intracellular calcium mobiliser), in accordance to in vitro release and microdialysis studies. These results demonstrate that live cell imaging can be achieved in magnocellular neurons, providing a robust model system in the study of dendritic peptide release. Large dense core vesicles (LDCVs) in other cell types such as bovine adrenal chromaffin cells were shown to segregate according to vesicle age, suggesting that vesicle age is an important factor in the regulation of peptide release. Whether vesicles of different age groups exist in magnocellular dendrites is not known. Thus, biolistic transfection with exogenous fluorescent proteins for expression under temporal control was carried out. However, low transfection rate in magnocellular neurones and the high background fluorescence caused by scattered gold particles used as bullets for transfection deemed this method inappropriate for the purpose of imaging vesicles. Hence, development of an adenoviral transduction system was employed. By using an inducible adenovirus gene construct coupled with a fluorescent reporter gene, it is possible to visualise vesicle pool segregation under different experimental conditions. Subcloning of a red fluorescent construct tagged to ppANF was tested on PC12 cells to show targeting of fluorescence expression…

Subjects/Keywords: 612.8; Magnocellular neurones; vasopressin; neuronal dendrites; peptides; oxytocin

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APA (6^th Edition):

Monteiro, O. F. d. S. (2010). Mechanisms of dendritic peptide release. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4420

Chicago Manual of Style (16^th Edition):

Monteiro, Olivia F de S. “Mechanisms of dendritic peptide release.” 2010. Doctoral Dissertation, University of Edinburgh. Accessed October 15, 2019. http://hdl.handle.net/1842/4420.

MLA Handbook (7^th Edition):

Monteiro, Olivia F de S. “Mechanisms of dendritic peptide release.” 2010. Web. 15 Oct 2019.

Vancouver:

Monteiro OFdS. Mechanisms of dendritic peptide release. [Internet] [Doctoral dissertation]. University of Edinburgh; 2010. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1842/4420.

Council of Science Editors:

Monteiro OFdS. Mechanisms of dendritic peptide release. [Doctoral Dissertation]. University of Edinburgh; 2010. Available from: http://hdl.handle.net/1842/4420

18. Kastellakis, Georgios. Dendritic contributions to neuronal and synaptic memory allocation.

Degree: 2016, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/38740

►

It is generally accepted that the brain stores memories in distributed neuronal representations. The long-term storage of memories is believed to take place through the… (more)

▼

It is generally accepted that the brain stores memories in distributed neuronal representations. The long-term storage of memories is believed to take place through the strengthening and weakening of synaptic connections between neurons. Recent research has begun to probe the mechanisms that underlie these changes in synaptic connections and to identify the correlates of specific memories in the brain, which are known as memory engrams or traces. These studies have identified a number of different factors, which determine memory storage, from molecular processes to network electrophysiological phenomena. Despite this progress in identifying pieces of the puzzle of the mechanism of memory, we are still lacking a unified framework, which can explain the experimental findings with regards to memory, and can predict the structure of memory traces. In this thesis we present a novel modeling approach to memory acquisition which combines multiple experimentally observed phenomena. We apply this model in specific well-studied memory-related experimental protocols and we use it to predict the structure of the resulting memory traces in multiple spatial scales, from the synaptic to the neuronal network level. In order to create a unifying framework for studying memory formation we incorporate mechanisms related to the consolidation of long-term memories in the brain. These include the mechanisms for plasticity-related protein capture according to the synaptic tagging and capture model, the localized modulation of excitability, as well as the effects of homeostasis and inhibition. Importantly, we study the effect of dendritic compartmentalization, which is known to affect memory, by incorporating dendritic phenomena in the description of neurons. Using this model, we show that the sub-cellular structure of memories, which consists of the distribution of synapses to specific neurons and specific dendritic branches is dependent on the ability of neurons to synthesize plasticity proteins in dendrites, and on the activation history of the neuron, which affects its excitability. In addition, we find that synapses tend to potentiate in groups, a phenomenon known as synapse clustering. We extend the model to the case of multiple memories in order to examine their possible interactions and find that the neuronal populations and the synapses that represent time-related memories are intertwined. Using the model, we predict the overlapping components of different memories as a function of time. Finally, we examine the role of dendritic spine reorganization, which occurs constantly in the brain, in the storage of memories.

Είναι γενικά αποδεκτό ότι ο οι μνήμες αποθηκεύονται με διάσπαρτο τρόπο στον εγκέφαλο. Η μακρόχρονη αποθήκευση της μνήμης πιστεύεται ότι λαμβάνει χώρα μέσω της ενδυνάμωσης και αποδυνάμωσης των συναπτικών συνδέσεων μεταξύ νευρώνων. Πρόσφατες έρευνες έχουν αρχίσει να εξερευνούν τους μηχανισμούς μέσω των οποίων γίνονται αυτές οι συνδέσεις, και να ταυτοποιούν το βιοφυσικό υπόστρωμα στο οποίο αποθηκεύονται συγκεκριμένες…

Subjects/Keywords: Υπολογιστική νευροεπιστήμη; ΜΝΗΜΗ (LONG TERM POTENTIATION); Δενδρίτες; Computational neuroscience; Dendrites

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APA (6^th Edition):

Kastellakis, G. (2016). Dendritic contributions to neuronal and synaptic memory allocation. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/38740

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kastellakis, Georgios. “Dendritic contributions to neuronal and synaptic memory allocation.” 2016. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed October 15, 2019. http://hdl.handle.net/10442/hedi/38740.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kastellakis, Georgios. “Dendritic contributions to neuronal and synaptic memory allocation.” 2016. Web. 15 Oct 2019.

Vancouver:

Kastellakis G. Dendritic contributions to neuronal and synaptic memory allocation. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10442/hedi/38740.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kastellakis G. Dendritic contributions to neuronal and synaptic memory allocation. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. Available from: http://hdl.handle.net/10442/hedi/38740

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

19. Vega, Jose A. Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids.

Degree: MS, Chemical Engineering, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/28223

► In this work, ionic liquids (ILs) were investigated for use as battery electrolytes. The ILs were synthesized from quaternary ammonium and phosphonium salts and TFSI-.… (more)

▼ In this work, ionic liquids (ILs) were investigated for use as battery electrolytes. The ILs were synthesized from quaternary ammonium and phosphonium salts and TFSI-. A dendrite free lithium metal anode was demonstrated by deposition of a lithium-potassium alloy. Several phosphonium ILs were synthesized using the TFSI- and PF6- anions until a room temperature IL was obtained. The smaller size, highly symmetric PF6- anion yielded high melting point salts, while TFSI- yielded much lower melting point ILs. When a room temperature IL, Bu3HexP+TFSI-, was obtained the analogous ammonium IL, Bu3HexP+TFSI-, was synthesized and compared. The phosphonium-based ionic liquid showed improved stability and physical properties compared to the analogous ammonium-based IL. The phosphonium-based IL had higher conductivity, 0.43 mS/cm, than the ammonium-based IL, 0.28 mS/cm. The addition of LiTFSI to both ILs led to a decrease in conductivity and increase in viscosity. The lower viscosity and higher stability of the phosphonium-based IL led to higher current density and stability for electrodeposited lithium metal. IL reduction interfered with lithium deposition reflecting lower coulombic efficiencies and giving the appearance of an unstable lithium couple. An optimum deposition potential was found which was bounded by the electrochemical stability of each IL. The stability of lithium in the ILs increased at lower temperature due to slower reactivity with the IL. Addition of higher quantities of lithium ions caused a higher fraction of the cathodic current going to lithium deposition that was reoxidized. The stability of lithium in the ILs increased at lower temperature due to slower reactivity with the IL. The electrodeposition and reoxidation of potassium was also demonstrated. Deposition of a lithium-potassium alloy caused slight increases in the cathodic and anodic currents along with higher coulombic efficiencies. Also, it was found that a lithium-potassium alloy could be deposited at high current for long times without the occurrence of dendrites. Advisors/Committee Members: Paul Kohl (Committee Chair), Jiri Janata (Committee Member), Tom Fuller (Committee Member).

Subjects/Keywords: Alloy deposition; Dendrites; Phosphonium; Ammonium; Ionic liquids; Ionic solutions; Electrolytes; Lithium

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APA (6^th Edition):

Vega, J. A. (2009). Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/28223

Chicago Manual of Style (16^th Edition):

Vega, Jose A. “Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids.” 2009. Masters Thesis, Georgia Tech. Accessed October 15, 2019. http://hdl.handle.net/1853/28223.

MLA Handbook (7^th Edition):

Vega, Jose A. “Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids.” 2009. Web. 15 Oct 2019.

Vancouver:

Vega JA. Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids. [Internet] [Masters thesis]. Georgia Tech; 2009. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1853/28223.

Council of Science Editors:

Vega JA. Electrochemical comparison and deposition of lithium and potassium from phosphonium- and ammonium-tfsi ionic liquids. [Masters Thesis]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/28223

University of Edinburgh

20. Oyebode, Oyinlola R. O. Protection of neuromuscular sensory endings by the WldS gene.

Degree: PhD, 2009, University of Edinburgh

URL: http://hdl.handle.net/1842/4234

► The compartmental hypothesis of neurodegeneration proposes that the neurone, long recognized to consist of morphologically and functionally distinct compartments, also houses distinct degeneration mechanisms for… (more)

▼ The compartmental hypothesis of neurodegeneration proposes that the neurone, long recognized to consist of morphologically and functionally distinct compartments, also houses distinct degeneration mechanisms for the soma, axon and nerve endings. Support for this hypothesis is provided by the phenomenon of the WldS (for Wallerian Degeneration, slow) mouse, a mutant in which axons survive several weeks after transection, rather than degenerating within 24-48 hours as in wild type mice, by virtue of expression of a chimeric Nmnat1/Ube4b protein. In this thesis I used the WldS-mouse to re-examine and extend the theory of compartmental neurodegeneration by focusing specifically on sensory axons and endings; and finally by considering a fourth compartment, the dendrites. The first part of this thesis reports that Ia afferent axons and their annulospiral endings are robustly protected from degeneration in WldS mice. Homozygous or heterozygous WldS mice crossbred with transgenic mice expressing fluorescent protein in neurones were sacrificed at various times after sciatic nerve transection. Fluorescence microscopy of whole mount preparations of lumbrical muscles in these mice revealed excellent preservation of annulospiral endings on muscle spindles for at least 10 days after axotomy. No significant difference was detected in the protection with age or gene copy-number in contrast to the protection of motor nerve terminals, which degenerate rapidly in heterozygote and aged homozygote WldS mice. In an attempt to explain the difference in motor and sensory protection by WldS, examination of three hypotheses was undertaken: a) differences in protein expression, tested by western blot and immunohistochemistry; b) differences in the degree of neuronal branching, tested through examination of g-motor axons and endings which have a degree of branching intermediate to motor and sensory neurons; and c) differences in the activity in the disconnected stumps, through primary culture of the saphenous and phrenic nerve, selected because they comprise largely pure sensory and motor axons respectively. The data suggest that none of these hypotheses provides a sufficient explanation for the difference between sensory and motor protection by WldS. The last part of this thesis attempts to extend the theory of compartmental degeneration. I examine a system for investigation of WldS-mediated protection of dendrites. In preliminary experiments retinal explants from transgenic mice expressing YFP in a subset of retinal ganglion-cell neurones were cultured. The dendritic arbours of these cells were shown to be amenable for repeated visualization and accessible to injury and monitoring of degeneration. Overall the data in this thesis suggest that the level of WldS -mediated protection conferred to an axon or axonal endings varies between different neuronal types. This has implications for the potential applications of WldS research to clinical problems. Specifically, the data imply that sensory neuropathies may benefit more than motor neuropathies…

Subjects/Keywords: 612.8; neurodegeneration; soma; axon; nerve endings; dendrites; WldS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oyebode, O. R. O. (2009). Protection of neuromuscular sensory endings by the WldS gene. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4234

Chicago Manual of Style (16^th Edition):

Oyebode, Oyinlola R O. “Protection of neuromuscular sensory endings by the WldS gene.” 2009. Doctoral Dissertation, University of Edinburgh. Accessed October 15, 2019. http://hdl.handle.net/1842/4234.

MLA Handbook (7^th Edition):

Oyebode, Oyinlola R O. “Protection of neuromuscular sensory endings by the WldS gene.” 2009. Web. 15 Oct 2019.

Vancouver:

Oyebode ORO. Protection of neuromuscular sensory endings by the WldS gene. [Internet] [Doctoral dissertation]. University of Edinburgh; 2009. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1842/4234.

Council of Science Editors:

Oyebode ORO. Protection of neuromuscular sensory endings by the WldS gene. [Doctoral Dissertation]. University of Edinburgh; 2009. Available from: http://hdl.handle.net/1842/4234

Cornell University

21. Kishore, Sandeep. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish .

Degree: 2011, Cornell University

URL: http://hdl.handle.net/1813/33616

► The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that… (more)

▼ The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that drive swimming in larval zebrafish. I first looked at the dendritic organization of motoneurons in freely swimming fish and tracked its emergence in relation to the maturation of locomotor behavior. I used transient expression of fluorescent proteins to visualize the dendritic structure of motoneurons in zebrafish larvae at a stage when they have been swimming freely for a few days. My work showed that there is a dendritic topography related to the recruitment of motoneurons at different locomotor speeds that emerges by the time fish first begin to swim, and is maintained even as dendrites grow after the onset of spontaneous swimming. Since neuronal activity is thought to influence dendritic structure, I then studied the structural dynamics of dendritic arbors of individual motoneurons in larval zebrafish soon after they begin swimming. I found a systematic relationship between the location of a spinal motoneuron and the dynamics of its dendritic arbor - youngest, ventral motoneurons are least dynamic whereas increasingly older and more dorsal motoneurons are more dynamic. This is contrary to the idea that dendrites of younger neurons are more dynamic than dendrites of older neurons because younger ones are growing more. I then asked if this pattern of dendritic dynamics is related to the systematic variation of excitability of motoneurons described recently. I tested this possibility genetically by expressing Kir2.1 to suppress excitability of individual motoneurons. This led to a dramatic increase in the dynamics of ventral motoneurons, which became more dynamic than more dorsal ones. My results suggest that a naturally occurring dorsoventral gradient of excitability may contribute to the variation in dendritic dynamics. The patterns of dendritic organization and development I describe may also be applicable to other interneuron types in the spinal cord and hindbrain. Advisors/Committee Members: Deitcher, David Lawrence (committeeMember), Harris-Warrick, Ronald Morgan (committeeMember).

Subjects/Keywords: Dendrites; Motoneurons; Zebrafish; Development; Filopodia; Imaging; Motor networks

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kishore, S. (2011). The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/33616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish .” 2011. Thesis, Cornell University. Accessed October 15, 2019. http://hdl.handle.net/1813/33616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish .” 2011. Web. 15 Oct 2019.

Vancouver:

Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish . [Internet] [Thesis]. Cornell University; 2011. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1813/33616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish . [Thesis]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

22. Vlasits, Anna Louise. Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development.

Degree: Neuroscience, 2017, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/224949wn

► The retina in our eyes is full of tiny neuronal computers, cells with diversely elaborate dendritic arbors that transform, sort, and integrate information about light… (more)

▼ The retina in our eyes is full of tiny neuronal computers, cells with diversely elaborate dendritic arbors that transform, sort, and integrate information about light bouncing off of objects in the world. The focus of this dissertation was to understand how dendrites of one type of cell in the retina, called the starburst amacrine cell, perform computations on visual information. The starburst amacrine cell is a part of the retina’s “direction selective circuit”, a model system for studying the cellular and synaptic implementation of a neural computation. Within this circuit, the starburst amacrine cells are responsible for detecting the direction of motion in the environment—right, left, up, or down—and cueing downstream cells, which pass on this information about motion direction to the brain. To begin, Chapter I presents the recent advances in our understanding of how the direction selective circuit works. Then, the experimental investigations presented in this dissertation attempt to clarify three issues about starburst amacrine cells. First, I examined the precise role of starburst amacrine cells in the direction selective circuit by altering their response properties and investigating how the performance of the circuit changes (Chapter II). I found that perturbations to the excitatory inputs to starburst amacrine cells using either visual adaptation of the retina or a chemo-genetic manipulation substantially altered the computational output of the entire circuit. Second, I described how the cells’ excitatory synaptic inputs are organized and contribute to the cells’ computations (Chapter III). I discovered that the precise distribution of excitatory inputs to the starburst amacrine cells shapes the cells’ ability to detect motion direction. Because of the elaborate structure of the dendrites, this precise arrangement is necessary for the electrical signals coming at different times and onto different dendritic locations to be integrated together in a direction-dependent fashion. Third, I investigated the development of the excitatory inputs to starburst amacrine cells and starburst amacrine cells’ velocity tuning (Chapter IV). These preliminary experiments provide a framework for further inquiry in these areas. Together, these experiments reveal how anatomical wiring and electrical properties of neurons in the retina produce exquisite computational abilities.

Subjects/Keywords: Neurosciences; dendrites; dendritic integration; direction selective ganglion cells; direction selectivity; retina

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APA (6^th Edition):

Vlasits, A. L. (2017). Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/224949wn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vlasits, Anna Louise. “Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development.” 2017. Thesis, University of California – Berkeley. Accessed October 15, 2019. http://www.escholarship.org/uc/item/224949wn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vlasits, Anna Louise. “Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development.” 2017. Web. 15 Oct 2019.

Vancouver:

Vlasits AL. Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development. [Internet] [Thesis]. University of California – Berkeley; 2017. [cited 2019 Oct 15]. Available from: http://www.escholarship.org/uc/item/224949wn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vlasits AL. Excitatory Inputs to Starburst Amacrine Cells: Adaptation, Computations, Development. [Thesis]. University of California – Berkeley; 2017. Available from: http://www.escholarship.org/uc/item/224949wn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

23. Behabadi, Bardia Fallah. Two-layer synaptic integration in pyramidal neurons.

Degree: PhD, Biomedical Engineering, 2011, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/666680/rec/7632

► Until recently, the accepted view of synaptic integration in most CNS neurons, including pyramidal neurons of the neocortex, has involved the vague notion that neurons… (more)

▼ Until recently, the accepted view of synaptic integration in most CNS neurons, including pyramidal neurons of the neocortex, has involved the vague notion that neurons ""sum"" their inputs from across their entire dendritic trees in some simple (e.g. linear) way, and fire action potentials when the axo-somatic spike threshold is crossed. ❧ However, evidence accumulating since the 1990's shows that active mechanisms in dendrites can produce local spikes that do not actively propagate to other parts of the cell, providing an additional 'layer' of nonlinear processing between synaptic inputs and the spike generation stage at the soma. But the recognition that dendrites can themselves act as separately-thresholded integrative subunits brought with it the same vague notion that dendrites also 'sum' their inputs in a simple way before generating local spikes once a local spike threshold is crossed. ❧ This idea of simple summation, though vague, has led to useful abstractions of synaptic integration. In the first instance they led to the point neuron abstraction for a neuron in which all synaptic potentials combine at the soma through a simple mathematical function (e.g. linear summation), and the resulting value then feeds into a global output nonlinearity essentially representing the cell's f-I curve. In the second instance it led to the 2-layer model developed previously in our lab, which extended the point neuron abstraction to two layers: synaptic inputs to a dendrite combine additively to drive a sigmoidal dendritic nonlinearity, and then all the dendritic 'outflows' combine linearly at the soma before feeding into the cell's global output nonlinearity. ❧ The 2-layer abstraction, while providing a more accurate description of a neuron's input-output behavior than the point neuron model, makes two key assumptions: 1) a dendrite's response depends only on the weighted sum of its own synaptic inputs, ignoring any spatial or other interactions between synapses that might exist within a subunit, and 2) dendrites operate independently of one another, that is, the output of one dendrite depends only on its own synaptic inputs, and is invariant to the ongoing activity within all the other dendrites, and the neuron as a whole. ❧ The first assumption raises an important unanswered question: whether integration within a dendrite depends, and if so how, on the absolute and relative locations of its activated synapses. The second assumption of subunit independence is also questionable, given that dendritic responses necessarily depend to some extent on local voltage-sensitive mechanisms, and voltage signals, such as back-propagating action potentials, do enter a dendrite carrying information from other parts of the cell. ❧ We address the first assumption through the use of both simple and complex compartmental models of a neocortical pyramidal neuron, whose results are compared to brain slice data gather in experiments conducted in Jackie Schiller's lab at the Technion in Haifa, Israel. The compartmental modeling experiments… Advisors/Committee Members: Mel, Bartlett W. (Committee Chair), Grzywacz, Norberto M. (Committee Member), Hirsch, Judith A. (Committee Member).

Subjects/Keywords: basal Dendrites; NMDA; pyramidal neurons; synaptic integration; compartmental modeling; electrophysiology

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APA (6^th Edition):

Behabadi, B. F. (2011). Two-layer synaptic integration in pyramidal neurons. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/666680/rec/7632

Chicago Manual of Style (16^th Edition):

Behabadi, Bardia Fallah. “Two-layer synaptic integration in pyramidal neurons.” 2011. Doctoral Dissertation, University of Southern California. Accessed October 15, 2019. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/666680/rec/7632.

MLA Handbook (7^th Edition):

Behabadi, Bardia Fallah. “Two-layer synaptic integration in pyramidal neurons.” 2011. Web. 15 Oct 2019.

Vancouver:

Behabadi BF. Two-layer synaptic integration in pyramidal neurons. [Internet] [Doctoral dissertation]. University of Southern California; 2011. [cited 2019 Oct 15]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/666680/rec/7632.

Council of Science Editors:

Behabadi BF. Two-layer synaptic integration in pyramidal neurons. [Doctoral Dissertation]. University of Southern California; 2011. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/666680/rec/7632

University of Western Ontario

24. Vu, Thy H. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3983

► Long-term potentiation at the distal apical dendrites of CA1 pyramidal cells. This study investigated whether a theta burst stimulation (TBS) tetanus could induce long-term potentiation… (more)

Subjects/Keywords: synaptic plasticity; hippocampus; memory formation; distal apical dendrites; CA1

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APA (6^th Edition):

Vu, T. H. (2016). Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Thesis, University of Western Ontario. Accessed October 15, 2019. https://ir.lib.uwo.ca/etd/3983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Web. 15 Oct 2019.

Vancouver:

Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2019 Oct 15]. Available from: https://ir.lib.uwo.ca/etd/3983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana Tech

25. Keck, Andrew G. A local model for dendritic solidification.

Degree: PhD, 1995, Montana Tech

URL: https://scholarworks.umt.edu/etd/10433

Subjects/Keywords: Dendrites.; Morphology Mathematical models.

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APA (6^th Edition):

Keck, A. G. (1995). A local model for dendritic solidification. (Doctoral Dissertation). Montana Tech. Retrieved from https://scholarworks.umt.edu/etd/10433

Chicago Manual of Style (16^th Edition):

Keck, Andrew G. “A local model for dendritic solidification.” 1995. Doctoral Dissertation, Montana Tech. Accessed October 15, 2019. https://scholarworks.umt.edu/etd/10433.

MLA Handbook (7^th Edition):

Keck, Andrew G. “A local model for dendritic solidification.” 1995. Web. 15 Oct 2019.

Vancouver:

Keck AG. A local model for dendritic solidification. [Internet] [Doctoral dissertation]. Montana Tech; 1995. [cited 2019 Oct 15]. Available from: https://scholarworks.umt.edu/etd/10433.

Council of Science Editors:

Keck AG. A local model for dendritic solidification. [Doctoral Dissertation]. Montana Tech; 1995. Available from: https://scholarworks.umt.edu/etd/10433

University of Edinburgh

26. Hasel, Philip. Investigation into the destructive and adaptive responses of neural cells to stress.

Degree: PhD, 2017, University of Edinburgh

URL: http://hdl.handle.net/1842/23547

► Homeostasis within the neuro-glial unit is essential to the longevity of neurons. Conversely, loss of homeostasis, particularly of Ca2+ levels, of redox balance and of… (more)

▼ Homeostasis within the neuro-glial unit is essential to the longevity of neurons. Conversely, loss of homeostasis, particularly of Ca2+ levels, of redox balance and of ATP, contribute to neuronal loss and dysfunction in many neurodegenerative and neurological disorders. This thesis is centred on better understanding the vulnerability of neurons to stress, as well as adaptive responses to these stresses. Since neurodegenerative conditions associated with Ca2+, redox and bioenergetic dyshomeostasis are often characterised by early dendritic pathology, I first studied dendritic vs. somatic responses of primary cortical neurons to these types of challenges in real-time. Using a wide range of genetically-encoded probes to measure Ca2+, ATP, NADH, glutathione and glutamate, I show that dendrites are selectively vulnerable to oxidative stress, excitotoxicity as well as to metabolic demand induced by action potential (AP) burst activity. However, I provide evidence that neurons undergoing energetically demanding AP burst activity can adjust their metabolic output by increasing mitochondrial NADH production in a manner dependent on the mitochondrial calcium uniporter (MCU), as well as increase their capacity to buffer their intracellular redox balance. Finally, I have studied transcriptional programs in astrocytes triggered by neurons and neuronal activity to better understand adaptive signaling between different cell types in the neuro-glial unit. I developed a novel system combining neurons and astrocytes from closely-related species, followed by RNA-seq and in silico read sorting. I uncovered a program of neuron-induced astrocytic gene expression which drives and maintains astrocytic maturity and neurotransmitter uptake function. In addition I identified a novel form of synapse-to-nucleus signaling, mediated by glutamatergic activity and acutely regulating diverse astrocytic genes involved in astrocyte-neuron metabolic coupling. Of note, neuronal activity co-ordinately induced astrocytic genes involved in astrocyte-to-neuron thyroid hormone signaling, extracellular antioxidant defences, and the astrocyte-neuron lactate shuttle, suggesting that this non cell-autonomous signaling may form part of the homeostatic machinery within the neuro-glial unit.

Subjects/Keywords: 612.8; adaptive responses; stress; dendrites; neurons; dendritic pathology; astrocytes; transcriptional programs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hasel, P. (2017). Investigation into the destructive and adaptive responses of neural cells to stress. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/23547

Chicago Manual of Style (16^th Edition):

Hasel, Philip. “Investigation into the destructive and adaptive responses of neural cells to stress.” 2017. Doctoral Dissertation, University of Edinburgh. Accessed October 15, 2019. http://hdl.handle.net/1842/23547.

MLA Handbook (7^th Edition):

Hasel, Philip. “Investigation into the destructive and adaptive responses of neural cells to stress.” 2017. Web. 15 Oct 2019.

Vancouver:

Hasel P. Investigation into the destructive and adaptive responses of neural cells to stress. [Internet] [Doctoral dissertation]. University of Edinburgh; 2017. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1842/23547.

Council of Science Editors:

Hasel P. Investigation into the destructive and adaptive responses of neural cells to stress. [Doctoral Dissertation]. University of Edinburgh; 2017. Available from: http://hdl.handle.net/1842/23547

Uppsala University

27. Yalamanchili, Anurag. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.

Degree: Structural Chemistry, 2014, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

►

In this thesis, the morphological changes of the anode surface in lithium sulphur cell, during early cycling, were simulated using symmetrical lithium electrode cells… (more)

Subjects/Keywords: Lithium sulphur batteries; Li anode; morphology; dendrites; pits; cycling

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APA (6^th Edition):

Yalamanchili, A. (2014). Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Thesis, Uppsala University. Accessed October 15, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Web. 15 Oct 2019.

Vancouver:

Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Internet] [Thesis]. Uppsala University; 2014. [cited 2019 Oct 15]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

28. Morát, Julia. Towards Stable Li-metal electrodefor rechargeable batteries.

Degree: Structural Chemistry, 2016, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

► Different types of alumina containing coatings were made on lithiumand copper in the purpose to mechanically hinder the growth ofdendrites. Lithium, coated with polymer-alumina… (more)

Subjects/Keywords: Lithium metal; Battery; Dendrites; light microscopy; Adiponitrile; Al2O3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morát, J. (2016). Towards Stable Li-metal electrodefor rechargeable batteries. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Thesis, Uppsala University. Accessed October 15, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Web. 15 Oct 2019.

Vancouver:

Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Internet] [Thesis]. Uppsala University; 2016. [cited 2019 Oct 15]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Thesis]. Uppsala University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

29. Qian, Cheng Sam. Internal tracheal sensory neuron wiring and function in Drosophila larvae.

Degree: 2018, Columbia University

URL: https://doi.org/10.7916/D8FJ40QH

► Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms,… (more)

▼ Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms, and circuitry are relatively poorly understood. To help address these gaps in knowledge, I used the tracheal dendrite (td) sensory neurons of Drosophila larvae as a model to gain insights into the cellular and molecular organization, developmental regulators, sensory functions and mechanisms, and downstream neural circuitry of internal sensory systems. In this thesis, I present data to show that td neurons comprise defined classes with distinct gene expression and axon projections to the CNS. The axons of one class project to the subesophageal zone (SEZ) in the brain, whereas the other terminates in the ventral nerve cord (VNC). This work identifies expression and a developmental role of the transcription factor Pdm3 in regulating the axon projections of SEZ-targeting td neurons. I find that ectopic expression of Pdm3 alone is sufficient to switch VNC-targeting td neurons to SEZ targets, and to induce the formation of putative synapses in these ectopic target regions. These results define distinct classes of td neurons and identity a molecular factor that contributes to diversification of central axon targeting. I present data to show that td neurons express chemosensory receptor genes and have chemosensory functions. Specifically, I show that td neurons express gustatory and ionotropic receptors and that overlapping subsets of td neurons are activated by decrease in O2 or increase in CO2 levels. I show that respiratory gas-sensitive td neurons are also activated when animals are submerged for a prolonged duration, demonstrating a natural-like condition in which td neurons are activated. I assessed the roles of chemosensory receptor genes in mediating the response of td neurons to O2 and CO2. As a result, I identify Gr28b as a mediator of td responses to CO2. Deletion of Gr28 genes or RNAi knockdown of Gr28b transcripts reduce the response of td neurons to CO2. Thus, these data identify two stimuli that are detected by td neurons, and establish a putative role for Gr28b in internal chemosensation in Drosophila larvae. Finally, I present data to elucidate the neural circuitry downstream of td sensory neurons. I show that td neurons synapse directly and via relays onto neurohormone populations in the central nervous system, providing neuroanatomical basis for internal sensory neuron regulation of hormonal physiology in Drosophila. These results pave the way for future work to functionally dissect the td circuitry to understand its function in physiology and behavior.

Subjects/Keywords: Neurosciences; Drosophila; Sensory neurons; Neurobiology; Dendrites; Neural circuitry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Qian, C. S. (2018). Internal tracheal sensory neuron wiring and function in Drosophila larvae. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8FJ40QH

Chicago Manual of Style (16^th Edition):

Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Doctoral Dissertation, Columbia University. Accessed October 15, 2019. https://doi.org/10.7916/D8FJ40QH.

MLA Handbook (7^th Edition):

Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Web. 15 Oct 2019.

Vancouver:

Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2019 Oct 15]. Available from: https://doi.org/10.7916/D8FJ40QH.

Council of Science Editors:

Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8FJ40QH

University of Toronto

30. Guet-McCreight, Alexandre Thomas Liam. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70331

►

In hippocampus, interneuron specific 3 (IS3) cells have been shown to make inhibitory synapses onto specific types of inhibitory interneuron dendrites with the ability to… (more)

Subjects/Keywords: Computational Neuroscience; Dendrites; Multi-Compartment Modeling; Voltage-Gated Channels; 0317

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guet-McCreight, A. T. L. (2015). Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70331

Chicago Manual of Style (16^th Edition):

Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Masters Thesis, University of Toronto. Accessed October 15, 2019. http://hdl.handle.net/1807/70331.

MLA Handbook (7^th Edition):

Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Web. 15 Oct 2019.

Vancouver:

Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1807/70331.

Council of Science Editors:

Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70331

Open Access Theses and Dissertations