subject:(Dendrites)

Rutgers University

1. Hernandez, Kristina, 1985-. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.

Degree: PhD, Cell and Developmental Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

►

Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several… (more)

▼

Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several neurodevelopmental disorders that are characterized by alterations in dendrite branching and spine density. NOS1AP is a protein encoded by a schizophrenia susceptibility gene, and its expression is upregulated in the dorsolateral prefrontal cortex of patients with schizophrenia. Previously, our laboratory showed that NOS1AP isoforms negatively regulate dendrite branching in cultured rat hippocampal neurons. Since dendrites and spines are influenced by changes in the cytoskeleton, we investigated whether the overexpression of NOS1AP isoforms in heterologous cells alters actin and microtubule organization. Overexpression of a long isoform of NOS1AP (NOS1AP-L) increases the presence of microtubule organizing centers, whereas overexpression of the short isoform of NOS1AP (NOS1AP-S) decreases microtubule organization. Furthermore, NOS1AP isoforms associate with F-actin in rat brain and can alter actin organization in distinct ways. NOS1AP-S increases actin polymerization, and its overexpression in HEK293T cells decreases total Rac1 and cofilin protein expression. To elucidate the role of NOS1AP in spine formation and synaptic function, we overexpressed NOS1AP isoforms in cultured rat cortical neurons. Overexpression of NOS1AP-L increases the number of immature spines, whereas overexpression of NOS1AP-S increases the number of mature and immature spines. In addition, overexpression of NOS1AP-S increases the frequency of miniature excitatory postsynaptic currents (mEPSCs) but not the amplitude. Overexpression of NOS1AP-L decreases the amplitude of mEPSCs but not the frequency. To investigate whether NOS1AP-L can mediate changes to dendrite patterning in vivo, we overexpressed NOS1AP-L in neuronal progenitor cells of the embryonic rat neocortex and analyzed dendrite patterning three weeks later. Neurons overexpressing NOS1AP-L in layers II/III of the neocortex exhibit a reduction in dendrite length and number. Finally, to investigate the role that NOS1AP plays in human dendritic arbor development, human neurons were generated using induced pluripotent stem cell technology. Overexpression of either NOS1AP-L or NOS1AP-S in human neurons results in a decrease in dendrite branching. Interestingly, treatment of human neurons with D-serine results in a reduction in NOS1AP-L protein expression. Taken together, our data support a role for NOS1AP-L and NOS1AP-S in dendritogenesis and synaptic function.

Advisors/Committee Members: Firestein, Bonnie L. (chair), Tischfield, Jay A. (internal member), Moore, Jennifer C. (internal member), Hart, Ronald P. (internal member), Brzustowicz, Linda M. (internal member), Silverstein, Steve (outside member).

Subjects/Keywords: Schizophrenia; Dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hernandez, Kristina, 1. (2015). The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

Chicago Manual of Style (16^th Edition):

Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Doctoral Dissertation, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.

MLA Handbook (7^th Edition):

Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Web. 07 Mar 2021.

Vancouver:

Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.

Council of Science Editors:

Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

Rutgers University

2. Patel, Mihir V., 1987-. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.

Degree: PhD, Neuroscience, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

►

Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its… (more)

▼

Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its interactor, cytosolic PSD-95 interactor (cypin), regulate dendrite branching by altering microtubule dynamics. Additionally, other PSD-95 binding proteins, end-binding protein 3 (EB3) and adenomatous polyposis coli (APC), promote microtubule bundling and stabilization. Thus, PSD-95 and binding partners may regulate the dendritic arbor during development and after injury. I first addressed the role of cypin in the brain in vivo. While generating cypin knockout mice, I identified a novel short isoform of cypin, termed cypinS, which also binds to PSD-95 and regulates dendrite branching, although an increase in dendrites occur more distal from the soma when cypinS is overexpressed compared to when cypin is overexpressed. In addition, unlike cypin, cypinS does not have guanine deaminase activity. Overexpression of cypin, but not cypinS, decreases spine density, suggestingiv that the regulation of spine density but not dendrite branching by cypin is dependent on guanine deaminase activity. Furthermore, I have uncovered novel presynaptic roles for both isoforms as overexpression of either isoform leads to increases in miniature excitatory postsynaptic current (mEPSC) frequency. Thus, cypin and cypinS, play distinct roles in neuronal development. I then chose to study the roles of PSD-95 and interactors in recovery after traumatic brain injury (TBI). We previously identified cypin as a novel target for TBI, and thus, here I studied the role of PSD-95 and its interaction with APC or EB3 in after injury induced by in vitro and in vivo models of TBI. I show that our in vitro model of mechanical stretch injury mimics moderate injury induced by controlled cortical impact (CCI) in mice. During the early stage (1-7 days) post-moderate CCI, the interaction of PSD-95 with APC and EB3 increases. Furthermore, downregulation of PSD-95 prevents stretch-injury mediated decreases in secondary dendrite number and total dendrite length, suggesting a required role of PSD-95 in injury-mediated insults to dendrites. Thus, PSD-95 may sequester APC and EB3 from microtubules to cause decreases in dendrite branching after TBI, and PSD-95 can be targeted as a novel approach for the treatment of patients with TBI.

Advisors/Committee Members: Firestein, Bonnie L (chair), Shumyatsky, Gleb (internal member), Alder, Janet (internal member), D’Arcangelo, Gabriella (internal member), Runnels, Loren (outside member), School of Graduate Studies.

Subjects/Keywords: Dendrites; Brain damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, Mihir V., 1. (2018). The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Chicago Manual of Style (16^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Doctoral Dissertation, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

MLA Handbook (7^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Web. 07 Mar 2021.

Vancouver:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

Council of Science Editors:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Vanderbilt University

3. Lee, Stacey Nicole. Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.

Degree: PhD, Biological Sciences, 2016, Vanderbilt University

URL: http://hdl.handle.net/1803/12348

► Appropriate neuronal morphogenesis is essential for forming the distinct functional domains of each of the hundreds of types of neurons in the brain. Generating the… (more)

▼ Appropriate neuronal morphogenesis is essential for forming the distinct functional domains of each of the hundreds of types of neurons in the brain. Generating the correct size and shape of dendrites is essential for a neuron to satisfactorily sample and process the signals that converge on its dendritic field. Understanding the control of neuronal circuit development is key to understanding normal and abnormal brain function and behavior. The habenular nuclei of the limbic system regulate responses, such as anxiety, to aversive stimuli in the environment. The habenulae receive inputs from the telencephalon via elaborate dendrites that form in the center of the nuclei. The kinase Ulk2 positively regulates dendritogenesis on habenular neurons, and in turn is negatively regulated by the cytoplasmic protein Kctd12. Given that the habenulae are a nexus in the aversive response circuit, we suspected that incomplete habenular dendritogenesis would have profound implications for behavior. We find that Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites. Loss of Kctd12 results in increased branching/elaboration and decreased anxiety. We conclude that fine-tuning of habenular dendritogenesis during development is essential for appropriate behavioral responses to negative stimuli. In addition to dendritic shaft development, dendritic spine development is a key event in synapse formation. Dendritic spines are protrusions emanating from the dendritic shaft that interact with axons to form excitatory synapses. Here we show that spinophilin/neurabin II, a scaffolding protein that is highly expressed in dendritic spines, has an important role in dendritic spine and synapse formation in hippocampal neurons. Knockdown of endogenous spinophilin with a short hairpin RNA (shRNA) causes a significant decrease in synapse and spine density, as shown by immunostaining for the presynaptic marker synaptic vesicle protein 2 and the postsynaptic marker postsynaptic density protein 95. On the other hand, expression of mCherry-spinophilin results in an increase in spine density. These results suggest that spinophilin is critical for dendritic spine and synapse formation. We hypothesized that spinophilin was promoting dendritic spine and synapse formation by regulating F-actin accumulation. Indeed, expression of GFP-spinophilin led to an increase in the amount of F-actin in spine heads. Collectively our data demonstrate an important function for spinophilin in modulating the formation of dendritic spines and synapses. Advisors/Committee Members: Donna Webb (committee member), Patrick Page-McCaw (committee member), Kevin Ess (committee member), Jim Patton (committee member), Douglas McMahon (Committee Chair).

Subjects/Keywords: neuroscience; dendritogenesis; dendritic spine; dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, S. N. (2016). Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12348

Chicago Manual of Style (16^th Edition):

Lee, Stacey Nicole. “Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed March 07, 2021. http://hdl.handle.net/1803/12348.

MLA Handbook (7^th Edition):

Lee, Stacey Nicole. “Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.” 2016. Web. 07 Mar 2021.

Vancouver:

Lee SN. Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1803/12348.

Council of Science Editors:

Lee SN. Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/12348

Rutgers University

4. Sweet, Eric S. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.

Degree: Neuroscience, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Subjects/Keywords: Microtubules; Dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sweet, E. S. (2011). To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Thesis, Rutgers University. Accessed March 07, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Web. 07 Mar 2021.

Vancouver:

Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Internet] [Thesis]. Rutgers University; 2011. [cited 2021 Mar 07]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Thesis]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

5. Peng, Sheng-Shiang. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.

Degree: MS, Biology, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

► The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance… (more)

▼ The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance molecules and receptors control the majority of the circuitry events, including promotion or inhibition of neurite growth. Semphorin 3A, a secreted Class 3 Semaphorin member, is well known for its chemorepellent function on growth cone mediated by the Neuropilin1/PlexinA4 holoreceptor complex. Recently, it has been shown to have opposite cellular responses in promoting dendrite growth and branching in mouse cortical pyramidal neurons (1, 2). However, the mechanism underlying how Semaphorin 3A/Neuropilin1/Plexin-A4 signaling regulates dendrite elaboration is unclear. Here, I have shown the importance and function of three distinct domains in the cytoplasmic region of the signaling transducing receptor of Semaphorin 3A, Plexin-A4, in regulating cortical neuron dendritic morphology. Both the C1 and H/RBD domains were found to be sufficient to trigger cortical pyramidal neuron dendrite elaboration, while the C2 domain was not necessary for dendrites growth and branching. Using biochemical and molecular methods in combination with in vitro assays, I found and demonstrated that the Rho-GEF, FARP2 associates with PlexinA4 and mediates dendritic elaboration in primary cortical neurons following the ligand, Semaphorin 3A activation of the signaling pathway. In addition, I demonstrated that Plexin-A4 extracellular domains could interact with its co-receptor Neuropilin1, independent of the ligand Semaphorin 3A. Therefore, the extracellular Semaphorin domain may play a role in preventing Plexin-A4 activation, consistent with previous studies (3, 4). Previously, another member of the Type A Plexin receptor, Plexin-A3, was shown to play a key role in inhibiting cortical neuron dendritic spine morphogenesis in vivo (2). However, the mechanism of how Plexin-A3 signals to restrain spine formation is unknown. I have generated an array of Plexin-A3 cytoplasmic deletion mutant constructs, analogous to the Plexin-A4 deletion mutants used for this study for future studies in investigating cortical neuron dendritic spine morphology. These molecular tools that I have developed will be useful for researchers to investigate the intracellular signaling mechanisms of Semaphorin signaling in regulating neuron morphology. Taken together, my findings provide new insights to Plexin-A4 signaling, in particular, highlighting distinct intracellular domains and downstream effectors required for promoting dendritic morphology. Advisors/Committee Members: Tran, Tracy (chair), Haspel, Gal (internal member), Maurel, Patrice (internal member).

Subjects/Keywords: Neurons – Growth; Semaphorins; Dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peng, S. (2014). Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

Chicago Manual of Style (16^th Edition):

Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Masters Thesis, Rutgers University. Accessed March 07, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.

MLA Handbook (7^th Edition):

Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Web. 07 Mar 2021.

Vancouver:

Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Internet] [Masters thesis]. Rutgers University; 2014. [cited 2021 Mar 07]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.

Council of Science Editors:

Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Masters Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

Vrije Universiteit Amsterdam

6. Groen, M.R. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .

Degree: 2013, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/40417

Subjects/Keywords: neuroscience; dendrites; development

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Groen, M. R. (2013). Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/40417

Chicago Manual of Style (16^th Edition):

Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .” 2013. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed March 07, 2021. http://hdl.handle.net/1871/40417.

MLA Handbook (7^th Edition):

Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity .” 2013. Web. 07 Mar 2021.

Vancouver:

Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1871/40417.

Council of Science Editors:

Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2013. Available from: http://hdl.handle.net/1871/40417

Baylor University

7. Hamilton, Brent (Brent A.). Asymptotic arc-components in inverse limits of dendrites.

Degree: PhD, Mathematics., 2011, Baylor University

URL: http://hdl.handle.net/2104/8216

► We study asymptotic behavior arising in inverse limit spaces of dendrites. In particular, the inverse limit is constructed with a single unimodal bonding map, for… (more)

Subjects/Keywords: Topology.; Continuum theory.; Inverse limits.; Dendrites.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamilton, B. (. A. ). (2011). Asymptotic arc-components in inverse limits of dendrites. (Doctoral Dissertation). Baylor University. Retrieved from http://hdl.handle.net/2104/8216

Chicago Manual of Style (16^th Edition):

Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites.” 2011. Doctoral Dissertation, Baylor University. Accessed March 07, 2021. http://hdl.handle.net/2104/8216.

MLA Handbook (7^th Edition):

Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites.” 2011. Web. 07 Mar 2021.

Vancouver:

Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Internet] [Doctoral dissertation]. Baylor University; 2011. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2104/8216.

Council of Science Editors:

Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Doctoral Dissertation]. Baylor University; 2011. Available from: http://hdl.handle.net/2104/8216

Boston University

8. Burgess, JoColl Alexis. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.

Degree: MS, Anatomy & Neurobiology, 2018, Boston University

URL: http://hdl.handle.net/2144/31219

► Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of… (more)

▼ Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of the brain. Structural and morphological changes in cellular alignment in the minicolumns correlate with increased prevalence of neurological diseases and in aging. In the rhesus monkey, cognitive decline is similar to what humans experience in aging. In the monkey prefrontal cortex, Brodmann area 46, an important region for executive functioning, cognitive decline correlates with changes in cellular alignment or “columnar strength” as studies by Cruz et al., (2009). Using the density maps method in Area 46, the ventral bank was identified to be the most susceptible to structural changes. Minicolumns, are defined by the cellular alignment of neurons in the cortex and some believe that the dendritic bundles of neurons in the cortex is also considered an integral part of the columns. The functional role of apical dendrites, is not well understood, however, given the that repeated organized bundles transverse through the laminae could be further support for their inclusion in minicolumns with possible functional importance. If structural changes such as loss of columnar strength (neuronal displacement) that correlates with cognitive aging, it is possible that the dendritic organization may also be affected in this area. In this thesis, it is hypothesized that the dendritic bundles in this area could also be related to the cognitive deficits associated with normal aging. Using double- fluorescence labeling for dendrites (MAP-2) and neurons (Neu-N), 3D confocal reconstructions of the dorsal and ventral banks of Area 46 were used to investigate structural/morphological changes in the dendritic bundles in young and old rhesus monkeys. While cortical thickness and apical dendritic length between both banks did not change, we found a significant increase in inter-bundle spacing at layer 6A in the older monkeys in the ventral bank. Inter-bundle spacing for bundles in layer 5 was measured and showed that the young consistently have smaller inter-bundle spacing. Future studies with larger sample size will also investigate whether changes in dendritic bundles and their organization also correlate with age-related cognitive deficits. Advisors/Committee Members: Zumwalt, Ann C. (advisor).

Subjects/Keywords: Neurosciences; Minicolumns; Monkeys; Area 46; Apical dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burgess, J. A. (2018). 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/31219

Chicago Manual of Style (16^th Edition):

Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Masters Thesis, Boston University. Accessed March 07, 2021. http://hdl.handle.net/2144/31219.

MLA Handbook (7^th Edition):

Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Web. 07 Mar 2021.

Vancouver:

Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2144/31219.

Council of Science Editors:

Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/31219

George Mason University

9. Rubaharan, Myurajan. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .

Degree: 2014, George Mason University

URL: http://hdl.handle.net/1920/9111

► Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional nervous system. Dendrites,… (more)

▼ Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional nervous system. Dendrites, as the primary sites of synaptic and/or sensory input largely determine the size and nature of the neuronal receptive field. The Drosophila melanogaster peripheral nervous system (PNS) has emerged as an excellent model system for studying molecular mechanisms underlying class specific dendrite development. Dendritic arborization (da) neurons are grouped into four distinct classes (I- IV) based upon increasing orders of dendritic complexity (Grueber et al., 2002). A recent study has identified dar1, a Krüppel-like transcription factor, as an essential regulator involved in controlling dendrite development and growth via microtubule modulation (Ye et al., 2011). Interestingly, at the embryonic stage Dar1 protein exhibits nuclear localization in all da neuron subclasses, however at the third instar larval stage of development, Dar1 exhibits a subcellular shift towards class-specific differential localization. Specifically, Dar1 is primarily nuclear in the morphologically simple class I neurons, in contrast to largely cytoplasmic localization in the highly complex class IV da neurons. This observation led us to investigate putative protein interaction partners of Dar1 that potentially regulate this class specific differential localization, and the result of perturbing this localization. We conducted a pilot RNAi screen of putative Dar1- interacting proteins to investigate their potential mechanistic role(s) in dendrite development and Dar1 differential localization in class IV da neurons. From this pilot screen, we identified the CBP/p300 homolog nejire (nej) as a novel regulator of dendritic development that also modulates Dar1 subcellular localization. We have conducted detailed structure-function studies using domain-specific deletions of nej that have provided further insights into the specific role of different protein domains in mediating distinct aspects of dendritic growth. Furthermore, we have used these domain-specific deletion constructs to elucidate the interaction between Dar1 and Nej. Collectively, these analyses contribute to our understanding of molecular mechanisms of combinatorial transcription factor activity at a class-specific level and how this regulation contributes to specification of distinct neuronal morphologies that underlie the establishment of complex neural networks. Advisors/Committee Members: Cox, Daniel N (advisor).

Subjects/Keywords: dendrites; neuron; Drosophila; transcription factor; Nejire; Dar1

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rubaharan, M. (2014). Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/9111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .” 2014. Thesis, George Mason University. Accessed March 07, 2021. http://hdl.handle.net/1920/9111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons .” 2014. Web. 07 Mar 2021.

Vancouver:

Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . [Internet] [Thesis]. George Mason University; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1920/9111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons . [Thesis]. George Mason University; 2014. Available from: http://hdl.handle.net/1920/9111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

10. Lee, Kuo-Sheng. MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.

Degree: 2019, Florida Atlantic University

URL: http://fau.digital.flvc.org/islandora/object/fau:41947

►

The physical architecture of neural circuits is thought to underlie the computations that give rise to higher order feature sensitivity in the neocortex. Recent technological… (more)

Subjects/Keywords: Neocortex; Visual Cortex – physiology; Neural circuitry; Dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, K. (2019). MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:41947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Kuo-Sheng. “MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.” 2019. Thesis, Florida Atlantic University. Accessed March 07, 2021. http://fau.digital.flvc.org/islandora/object/fau:41947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Kuo-Sheng. “MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.” 2019. Web. 07 Mar 2021.

Vancouver:

Lee K. MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. [Internet] [Thesis]. Florida Atlantic University; 2019. [cited 2021 Mar 07]. Available from: http://fau.digital.flvc.org/islandora/object/fau:41947.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee K. MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. [Thesis]. Florida Atlantic University; 2019. Available from: http://fau.digital.flvc.org/islandora/object/fau:41947

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

11. Mul, M.M. (author). Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.

Degree: 2014, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

►

A three-dimensional mixed-mode cellular automaton model [C. Bos, M. G. Mecozzi, and J. Sietsma. Computational Materials Science 48.3 (2010): 692-699] for the austenite to ferrite… (more)

Subjects/Keywords: phase transformation; cellular automaton; steel alloy; dendrites

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mul, M. M. (. (2014). Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

Chicago Manual of Style (16^th Edition):

Mul, M M (author). “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.” 2014. Masters Thesis, Delft University of Technology. Accessed March 07, 2021. http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.

MLA Handbook (7^th Edition):

Mul, M M (author). “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.” 2014. Web. 07 Mar 2021.

Vancouver:

Mul MM(. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. [Internet] [Masters thesis]. Delft University of Technology; 2014. [cited 2021 Mar 07]. Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.

Council of Science Editors:

Mul MM(. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. [Masters Thesis]. Delft University of Technology; 2014. Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039

12. Ikpegbu, Ekele. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.

Degree: PhD, 2018, University of Edinburgh

URL: http://hdl.handle.net/1842/31361

► Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In… (more)

▼ Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In cartilage, FGF-2 regulates E11/podoplanin expression in murine joints following surgical destabilisation (DMM model of osteoarthritis (OA)), and in cartilage explant injury models. In bone, E11 is critical for the early stages of osteocytogenesis and is responsible for the acquisition of the osteocyte dendritic phenotype. This dendritic phenotype is dysregulated in OA and given the known role of the osteocyte in controlling bone remodelling, this may contribute to the subchondral bone thickening observed in OA. Hence, the aim of this study was to elucidate the nature of FGF-2- mediated E11 expression and osteocytogenesis in skeletal health and disease. This thesis has shown that FGF-2 dose-dependently increased E11 mRNA expression in MC3T3 cells, primary osteoblasts and in primary calvaria organ cultures, which was confirmed by E11 protein western blotting data. The FGF-2 induced changes in E11 expression were accompanied by significant increases in the mRNA expression of the osteocyte markers Phex and Dmp1, and significant decreases in the mRNA expression of the osteoblast markers Col1a1, Postn, Bglap and Alpl expression. This thus supports the hypothesis that FGF-2 drives osteocytogenesis. The acquisition of osteocyte phenotype involves the re-organisation of the cytoskeleton, such as F-actin. This step is important for the transition of cuboidal-shaped osteoblasts to the stellate-shaped osteocyte phenotype. FGF-2 stimulation of MC3T3 cells and primary osteoblasts revealed more numerous and longer dendrites, as visualised by phalloidin staining for F-actin and indicative of the acquisition of the osteocyte phenotype. In contrast, control cells had a typical rounded morphology with fewer and shorter dendrites. Furthermore, immunofluorescence labelling for E11 in control cells revealed uniform distribution throughout the cytoplasm, especially in the perinuclear region. In contrast, FGF-2 treated cells showed a modified distribution where E11 was negligible in the cytoplasm, but concentrated in the dendrites. The use of siRNA knockdown of E11 achieved a 70% reduction of basal E11 mRNA expression. This knockdown also effectively abrogated FGF-2-related changes in E11 expression and dendrite formation as disclosed by mRNA and protein expression, immunofluorescence and F-actin staining with phalloidin. Despite these FGF-2 driven increases in E11 and osteocyte dendrite formation in vitro, immunohistochemical labelling revealed no differences in E11 expression in subchondral, trabecular and cortical osteocytes from naïve Fgf-2 deficient mice in comparison to wild-type mice. Similar results were observed upon sclerostin immunolabelling. FGF-2 stimulation of MC3T3 cells elicited activation of ERK1/2, Akt and p38 MAPK. However, inhibition of the aforementioned pathways failed to reduce FGF-2- mediated E11 expression and as such, the specific signalling pathway responsible…

Subjects/Keywords: 616.7; osteoblasts; osteocyte; dendrites; E11; FGF-2

12 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ikpegbu, E. (2018). Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/31361

Chicago Manual of Style (16^th Edition):

Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed March 07, 2021. http://hdl.handle.net/1842/31361.

MLA Handbook (7^th Edition):

Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Web. 07 Mar 2021.

Vancouver:

Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1842/31361.

Council of Science Editors:

Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/31361

Indiana University

13. Chew, Cory Charles. EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE .

Degree: 2020, Indiana University

URL: http://hdl.handle.net/2022/26089

► Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. It has been previously demonstrated that partial… (more)

Subjects/Keywords: Exercise; Androgens; Motoneurons; Dendrites; Neuroprotection; Hormones

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chew, C. C. (2020). EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE . (Thesis). Indiana University. Retrieved from http://hdl.handle.net/2022/26089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chew, Cory Charles. “EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE .” 2020. Thesis, Indiana University. Accessed March 07, 2021. http://hdl.handle.net/2022/26089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chew, Cory Charles. “EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE .” 2020. Web. 07 Mar 2021.

Vancouver:

Chew CC. EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE . [Internet] [Thesis]. Indiana University; 2020. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2022/26089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chew CC. EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE . [Thesis]. Indiana University; 2020. Available from: http://hdl.handle.net/2022/26089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Guinaudeau, Ophélie. Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.

Degree: Docteur es, Informatique, 2019, Université Côte d'Azur (ComUE)

URL: http://www.theses.fr/2019AZUR4001

►

Les neurones biologiques communiquent par le biais d’impulsions électriques, appelées spikes, et les fonctions cérébrales émergent notamment de la coordination entre les réceptions et émissions… (more)

▼

Les neurones biologiques communiquent par le biais d’impulsions électriques, appelées spikes, et les fonctions cérébrales émergent notamment de la coordination entre les réceptions et émissions de ces spikes. Par ailleurs, il est largement admis que la fonction de chaque neurone dépend de sa morphologie. Les dendrites conditionnent l’intégration spatio-temporelle des spikes reçus et influent sur les temps d’occurrence des spikes émis. Elles sont donc fondamentales pour l’étude in silico des mécanismes de coordination, et en particulier pour l’étude des assemblées de neurones. Les modèles de neurones existants prenant en compte les dendrites, sont généralement des modèles mathématiques détaillés, souvent à base d’équations différentielles, dont la simulation nécessite des ressources de calculs importantes. De plus, leur complexité intrinsèque rend difficile l’analyse et les preuves sur ces modèles. Dans cette thèse, nous proposons un modèle de neurone intégrant des dendrites d’une manière abstraite. Dans l’objectif d’ouvrir la porte aux méthodes formelles, nous établissons une définition rigoureuse du cadre de modélisation et mettons en évidence des propriétés algébriques remarquables de l’intégration dendritique. Nous avons notamment démontré qu’il est possible de réduire la structure d’un neurone en préservant sa fonction d’entrée/sortie. Nous avons ainsi révélé des classes d’équivalence dont nous savons déterminer un représentant canonique. En s’appuyant sur la théorie des catégories et par des morphismes de neurones judicieusement définis, nous avons ensuite analysé plus finement ces classes d’équivalence. Un résultat surprenant découle de ces propriétés : un simple ajout de délais dans les modèles informatiques de neurones permet de prendre en compte une intégration dendritique abstraite, sans représenter explicitement la structure arborescente des dendrites. À la racine de l’arborescence dendritique, la modélisation du soma contient inévitablement une équation différentielle lorsque l’on souhaite préserver l’essence du fonctionnement biologique. Ceci impose de combiner une vision analytique avec la vision algébrique. Néanmoins, grâce à une étape préalable de discrétisation temporelle, nous avons également implémenté un neurone complet en Lustre qui est un langage formel autorisant des preuves par model checking. Globalement, nous apportons dans cette thèse un premier pas encourageant vers une formalisation complète des neurones, avec des propriétés remarquables sur l’intégration dendritique.

Biological neurons communicate by means of electrical impulses, called spikes. Brain functions emerge notably from reception and emission coordination between those spikes. Furthermore, it is widely accepted that the function of each neuron depends on its morphology. In particular, dendrites perform the spatio-temporal integration of received spikes and affect the occurrence of emitted spikes. Dendrites are therefore fundamental for in…

Advisors/Committee Members: Bernot, Gilles (thesis director).

Subjects/Keywords: Modélisation formelle; Neurone; Dendrites; Propiétés algébriques; Délais; Lustre; Formal modelling; Neuron; Dendrites; Algebraic properties; Delays; Lustre

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guinaudeau, O. (2019). Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. (Doctoral Dissertation). Université Côte d'Azur (ComUE). Retrieved from http://www.theses.fr/2019AZUR4001

Chicago Manual of Style (16^th Edition):

Guinaudeau, Ophélie. “Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.” 2019. Doctoral Dissertation, Université Côte d'Azur (ComUE). Accessed March 07, 2021. http://www.theses.fr/2019AZUR4001.

MLA Handbook (7^th Edition):

Guinaudeau, Ophélie. “Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.” 2019. Web. 07 Mar 2021.

Vancouver:

Guinaudeau O. Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. [Internet] [Doctoral dissertation]. Université Côte d'Azur (ComUE); 2019. [cited 2021 Mar 07]. Available from: http://www.theses.fr/2019AZUR4001.

Council of Science Editors:

Guinaudeau O. Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. [Doctoral Dissertation]. Université Côte d'Azur (ComUE); 2019. Available from: http://www.theses.fr/2019AZUR4001

University of Utah

15. Newby, Jay. Molecular motor-based models of random intermittent search in dendrites.

Degree: PhD, Mathematics;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

► A key component in the cellular mechanisms underlying learning and memory involves the distribution and delivery of mRNA to synaptic sites in dendrites. A minimal… (more)

Subjects/Keywords: Dendrites; Intracellular transport; Jump velocity; Molecular motors; MRNA transport; Random search

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Newby, J. (2010). Molecular motor-based models of random intermittent search in dendrites. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

Chicago Manual of Style (16^th Edition):

Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Doctoral Dissertation, University of Utah. Accessed March 07, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.

MLA Handbook (7^th Edition):

Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Web. 07 Mar 2021.

Vancouver:

Newby J. Molecular motor-based models of random intermittent search in dendrites. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Mar 07]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.

Council of Science Editors:

Newby J. Molecular motor-based models of random intermittent search in dendrites. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

University of Alberta

16. Kim, Hojeong. Biophysics underlying bistable neurons with branching dendrites.

Degree: PhD, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/fq977w125

► The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons.… (more)

▼ The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons. After reviewing the relevant motoneuron physiology and theories that describe complex dendritic signaling properties, I hypothesize that at least five passive electrical properties must be considered to better understand the physiological input-output properties of motor neurons in vivo: input resistance, system time constant, and three signal propagation properties between the soma and dendrites that depend on the signal direction (i.e. soma to dendrites or vice versa) and type (i.e. direct (DC) or alternating (AC) current). To test my hypothesis, I begin with characterizing the signal propagation of the dendrites, by directly measuring voltage attenuations along the path of dendrites of the type-identified anatomical neuron models. Based on this characterization of dendritic signaling, I develop the novel realistic reduced modeling approach by which the complex geometry and passive electrical properties of anatomically reconstructed dendrites can be analytically mapped into simple two-compartment modeling domain without any restrictive assumptions. Combining mathematical analysis and computer simulations of my new reduced model, I show how individual biophysical properties (system input resistance, time constant and dendritic signaling) contribute to the local excitability of the dendrites, which plays an essential role in activating the plateau generating membrane mechanisms and subsequent nonlinear input-output relations in a single neuron. The biophysical theories and computer simulations in this thesis are primarily applied to motor neurons that compose the motor neuron pool for control of movement. However, the general features of the new reduced neuron modeling approach and important insights into neuronal computations are not limited to this area. My findings can be extended to other areas including artificial neural networks consisting of single compartment processors.

Subjects/Keywords: Dendrites; Neuron; Direction dependent voltage attenuation; Reduced modeling; Bistable firing behaviour

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, H. (2011). Biophysics underlying bistable neurons with branching dendrites. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/fq977w125

Chicago Manual of Style (16^th Edition):

Kim, Hojeong. “Biophysics underlying bistable neurons with branching dendrites.” 2011. Doctoral Dissertation, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/fq977w125.

MLA Handbook (7^th Edition):

Kim, Hojeong. “Biophysics underlying bistable neurons with branching dendrites.” 2011. Web. 07 Mar 2021.

Vancouver:

Kim H. Biophysics underlying bistable neurons with branching dendrites. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/fq977w125.

Council of Science Editors:

Kim H. Biophysics underlying bistable neurons with branching dendrites. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/fq977w125

Cornell University

17. Kishore, Sandeep. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.

Degree: PhD, Neurobiology, 2011, Cornell University

URL: http://hdl.handle.net/1813/33616

► The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that… (more)

▼ The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that drive swimming in larval zebrafish. I first looked at the dendritic organization of motoneurons in freely swimming fish and tracked its emergence in relation to the maturation of locomotor behavior. I used transient expression of fluorescent proteins to visualize the dendritic structure of motoneurons in zebrafish larvae at a stage when they have been swimming freely for a few days. My work showed that there is a dendritic topography related to the recruitment of motoneurons at different locomotor speeds that emerges by the time fish first begin to swim, and is maintained even as dendrites grow after the onset of spontaneous swimming. Since neuronal activity is thought to influence dendritic structure, I then studied the structural dynamics of dendritic arbors of individual motoneurons in larval zebrafish soon after they begin swimming. I found a systematic relationship between the location of a spinal motoneuron and the dynamics of its dendritic arbor - youngest, ventral motoneurons are least dynamic whereas increasingly older and more dorsal motoneurons are more dynamic. This is contrary to the idea that dendrites of younger neurons are more dynamic than dendrites of older neurons because younger ones are growing more. I then asked if this pattern of dendritic dynamics is related to the systematic variation of excitability of motoneurons described recently. I tested this possibility genetically by expressing Kir2.1 to suppress excitability of individual motoneurons. This led to a dramatic increase in the dynamics of ventral motoneurons, which became more dynamic than more dorsal ones. My results suggest that a naturally occurring dorsoventral gradient of excitability may contribute to the variation in dendritic dynamics. The patterns of dendritic organization and development I describe may also be applicable to other interneuron types in the spinal cord and hindbrain. Advisors/Committee Members: Fetcho, Joseph R. (chair), Deitcher, David Lawrence (committee member), Harris-Warrick, Ronald Morgan (committee member).

Subjects/Keywords: Dendrites; Motoneurons; Zebrafish; Development; Filopodia; Imaging; Motor networks

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kishore, S. (2011). The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/33616

Chicago Manual of Style (16^th Edition):

Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.” 2011. Doctoral Dissertation, Cornell University. Accessed March 07, 2021. http://hdl.handle.net/1813/33616.

MLA Handbook (7^th Edition):

Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.” 2011. Web. 07 Mar 2021.

Vancouver:

Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1813/33616.

Council of Science Editors:

Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33616

Cornell University

18. Tu, Zhengyuan. STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.

Degree: PhD, Materials Science and Engineering, 2018, Cornell University

URL: http://hdl.handle.net/1813/59396

► Significant advances in the amount of electrical energy that can be stored in electrochemical cells, such as rechargeable batteries require the adoption of high energy… (more)

▼ Significant advances in the amount of electrical energy that can be stored in electrochemical cells, such as rechargeable batteries require the adoption of high energy metallic anodes including Li, Na, Al, Zn, etc. Such anodes introduce as significant technical challenges because they are known to form rough electrodeposits, loosely termed dendrites, during the device operation. This produces irreversible active material (electrode and electrolyte) losses during normal cell operation and poses safety concerns because the dendrites can proliferate in the inter-electrode space, shorting the cell internally. Though similar phenomenon has been investigated in the more conventional context of metal electroplating, more complex effects can dominate in a battery configuration especially at current densities below the limiting current and in cells where the metal anodes undergo chemical reaction with electrolyte components. In this thesis, a comprehensive materials strategy involving structural and interfacial engineering is pursued to stabilize lithium metal electrodeposition. The strategy is based on guidelines defined by a theoretical linear stability analysis of metal electrodeposition in structured electrolytes. The origin of deposition instability is revealed to involve fundamental features of electrolytes and interfaces near metal anodes, which lead to electro- convective, morphological and chemical instability. I show that the first two instabilities can be addressed by using a nanostructured polymer/ceramic hybrid electrolyte, which exhibits high conductivity, high modulus and the ability to rectify ion transport through confinement. The well-defined nanoporous structure of the electrolytes also confine the length scale of the electrodeposit, which allows surface tension and other weaker forces at the interface to flatten rough electrodeposits, promoting dendrite-free operation. The chemical instability poses a more serious challenge because it is intrinsic to the chemistry of the electrode and electrolyte components; any exposure of one to the other can in principle drive a reaction cascade that ends in unconstrained growth in the cell impedance and premature failure. I show that this challenge can be overcome by the careful design of solid electrolyte interphases (SEIs) that regulate mass transport of reactive electrolyte ingredients and at the same time are able to flex to accommodate volume expansion of the anode. A significant finding is that these features can be realized using electrolyte additives designed to selectively break-down in-situ to form SEI with explicit composition set by the chemistry of the additive. A particularly important example are additives that break down to form halogen salts, which exhibit low surface diffusion barrier and fast interfacial transport. Such materials are shown to be highly effective in improve battery cycle lifetime. A second category of SEI explored in the study are so- called artificial SEI formed by pretreating the metallic electrode with polymer, metals, and metal… Advisors/Committee Members: Archer, Lynden A. (chair), Wiesner, Ulrich B. (committee member), Kourkoutis, Lena Fitting (committee member).

Subjects/Keywords: dendrites; Energy; Materials Science; alkali metals; lithium batteries; rechargeable batteries; electrodeposition

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tu, Z. (2018). STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/59396

Chicago Manual of Style (16^th Edition):

Tu, Zhengyuan. “STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.” 2018. Doctoral Dissertation, Cornell University. Accessed March 07, 2021. http://hdl.handle.net/1813/59396.

MLA Handbook (7^th Edition):

Tu, Zhengyuan. “STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.” 2018. Web. 07 Mar 2021.

Vancouver:

Tu Z. STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. [Internet] [Doctoral dissertation]. Cornell University; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1813/59396.

Council of Science Editors:

Tu Z. STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. [Doctoral Dissertation]. Cornell University; 2018. Available from: http://hdl.handle.net/1813/59396

Purdue University

19. Schartz, Nicole Denise. A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.

Degree: MS, Psychological Sciences, 2016, Purdue University

URL: https://docs.lib.purdue.edu/open_access_theses/1135

► Status epilepticus (SE) triggers pathological changes to hippocampal dendrites that may promote epileptogenesis. The microtubule associated protein 2 (Map2) helps stabilize microtubules of the dendritic… (more)

▼ Status epilepticus (SE) triggers pathological changes to hippocampal dendrites that may promote epileptogenesis. The microtubule associated protein 2 (Map2) helps stabilize microtubules of the dendritic cytoskeleton. Recently, we reported a substantial decline in Map2 that coincided with robust microglia accumulation in the CA1 hippocampal region after an episode of SE. A spatial correlation between Map2 loss and reactive microglia was also reported in human cortex from refractory epilepsy. New evidence supports that microglia are guided by proteins of the classical complement pathway (C1q and C3) to prune dendritic structures. Furthermore, components of complement have been shown to be upregulated in human and experimental epilepsy. Thus, to identify a potential role of the classical complement pathway in SE-induced Map2 and microglial changes, we characterized the spatiotemporal profile of these events. We used immunohistochemistry to determine the distribution of Map2 and the microglia marker IBA1 in the hippocampus after pilocarpine-induced SE from 4 hours to 35 days. We found a decline in Map2 immunoreactivity in the CA1 area that reached minimal levels at 14 days post-SE and partially increased thereafter. In contrast, maximal microglia accumulation occurred in the CA1 area at 14 days post-SE. We then mapped the spatiotemporal profile of C1q using immunohistochemistry at 3-35 days after SE, where substantial Map2 and microglial alterations were observed. We used western blot to determine the levels of C3 and its cleavage products. C1q and C3 were both increased in the hippocampus at 14 days after SE, when Map2 and microglia changes were most profound. Our data indicate that SE-induced Map2 and microglial changes parallel each other’s spatiotemporal profiles. These findings also suggest a potential role for the classical complement pathway in SE-induced Map2-microglial interactions. Advisors/Committee Members: Amy L Brewster, Christie Sahley, Susan Sangha, Kimberly Kinzig.

Subjects/Keywords: behavioral models; classical complement; dendrites; hippocampus; microglia; temporal lobe epilepsy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schartz, N. D. (2016). A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. (Thesis). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_theses/1135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schartz, Nicole Denise. “A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.” 2016. Thesis, Purdue University. Accessed March 07, 2021. https://docs.lib.purdue.edu/open_access_theses/1135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schartz, Nicole Denise. “A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.” 2016. Web. 07 Mar 2021.

Vancouver:

Schartz ND. A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. [Internet] [Thesis]. Purdue University; 2016. [cited 2021 Mar 07]. Available from: https://docs.lib.purdue.edu/open_access_theses/1135.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schartz ND. A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. [Thesis]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_theses/1135

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

20. Guet-McCreight, Alexandre Thomas Liam. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70331

►

In hippocampus, interneuron specific 3 (IS3) cells have been shown to make inhibitory synapses onto specific types of inhibitory interneuron dendrites with the ability to… (more)

Subjects/Keywords: Computational Neuroscience; Dendrites; Multi-Compartment Modeling; Voltage-Gated Channels; 0317

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guet-McCreight, A. T. L. (2015). Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70331

Chicago Manual of Style (16^th Edition):

Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Masters Thesis, University of Toronto. Accessed March 07, 2021. http://hdl.handle.net/1807/70331.

MLA Handbook (7^th Edition):

Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Web. 07 Mar 2021.

Vancouver:

Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1807/70331.

Council of Science Editors:

Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70331

Columbia University

21. Vaadia, Rebecca Danielle. Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.

Degree: 2020, Columbia University

URL: https://doi.org/10.7916/d8-9f48-0354

► A neuron’s function depends critically on the shape, size, and territory of its dendritic field. We have only recently begun to understand how diverse dendritic… (more)

▼ A neuron’s function depends critically on the shape, size, and territory of its dendritic field. We have only recently begun to understand how diverse dendritic arbors are built and how the morphology and territory of these arbors support diverse neural functions. In this thesis, I use the Drosophila larval peripheral nervous system (PNS) as a model for studying these questions, as these neurons are very amenable to genetic manipulation and in vivo imaging. First, I examined the relationship between dendritic fields and sensory activity in the proprioceptive neurons of the body wall. In collaboration with Elizabeth Hillman’s lab, we used a high-speed volumetric microscopy technique, Swept Confocally Aligned Planar Excitation (SCAPE) microscopy, to simultaneously image the dendrite deformation dynamics and sensory activity of body wall neurons in crawling Drosophila larvae. We imaged a set of proprioceptive neurons with diverse dendrite morphologies and territories, revealing that each neuron subtype responds in sequence during crawling. These activities could conceivably provide a continuum of position encoding during locomotion. Activity timing is related to the dynamics of each neuron’s dendritic arbors, suggesting arbor shape and targeting endow each proprioceptor with a specific role in monitoring body wall deformation. Furthermore, our results provide new insights into the body-wide activity dynamics of the proprioceptive system, which will inform models of sensory feedback during locomotion. To investigate how dendritic arbors are built to support sensory function, I focused on proprioceptive (class I) and touch-sensing (class II-III) dendritic arborization (da) neurons. Proprioceptive and touch-sensing dendrite territories tend to target non-overlapping, neighboring, areas of the body wall. How is territory coverage specified during development, and how does this coverage support a specific sensory function? Ablation studies indicate that repulsive interactions between heterotypic dendrites are not required for territory patterning. Instead, dendrite boundaries correlate with Anterior (A)-Posterior (P) compartment boundaries in the underlying epidermal substrate: proprioceptive class I dendrites target the P compartment, while touch-sensing dendrites tend to avoid that region. I found that genetic expansion of the P compartment leads to expansion of class I proprioceptive dendrites, suggesting compartmentalized epidermal cues instruct dendrite targeting. Furthermore, SCAPE imaging revealed that the P compartment coincides with a major body wall fold that occurs during crawling. These results support a model in which dendrite targeting by compartment cues reliably tunes neurons for predictable stimuli on the body wall: proprioceptive dendrites target areas that bend predictably during crawling, while touch-sensing dendrites could be avoiding those areas to be tuned for external mechanosensory stimuli. To investigate the molecular identity of the substrate cues guiding the compartmental organization of…

Subjects/Keywords: Neurosciences; Drosophila – Development; Dendrites; Senses and sensation; Proprioception

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaadia, R. D. (2020). Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-9f48-0354

Chicago Manual of Style (16^th Edition):

Vaadia, Rebecca Danielle. “Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.” 2020. Doctoral Dissertation, Columbia University. Accessed March 07, 2021. https://doi.org/10.7916/d8-9f48-0354.

MLA Handbook (7^th Edition):

Vaadia, Rebecca Danielle. “Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.” 2020. Web. 07 Mar 2021.

Vancouver:

Vaadia RD. Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Mar 07]. Available from: https://doi.org/10.7916/d8-9f48-0354.

Council of Science Editors:

Vaadia RD. Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-9f48-0354

Columbia University

22. Qian, Cheng Sam. Internal tracheal sensory neuron wiring and function in Drosophila larvae.

Degree: 2018, Columbia University

URL: https://doi.org/10.7916/D8FJ40QH

► Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms,… (more)

▼ Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms, and circuitry are relatively poorly understood. To help address these gaps in knowledge, I used the tracheal dendrite (td) sensory neurons of Drosophila larvae as a model to gain insights into the cellular and molecular organization, developmental regulators, sensory functions and mechanisms, and downstream neural circuitry of internal sensory systems. In this thesis, I present data to show that td neurons comprise defined classes with distinct gene expression and axon projections to the CNS. The axons of one class project to the subesophageal zone (SEZ) in the brain, whereas the other terminates in the ventral nerve cord (VNC). This work identifies expression and a developmental role of the transcription factor Pdm3 in regulating the axon projections of SEZ-targeting td neurons. I find that ectopic expression of Pdm3 alone is sufficient to switch VNC-targeting td neurons to SEZ targets, and to induce the formation of putative synapses in these ectopic target regions. These results define distinct classes of td neurons and identity a molecular factor that contributes to diversification of central axon targeting. I present data to show that td neurons express chemosensory receptor genes and have chemosensory functions. Specifically, I show that td neurons express gustatory and ionotropic receptors and that overlapping subsets of td neurons are activated by decrease in O2 or increase in CO2 levels. I show that respiratory gas-sensitive td neurons are also activated when animals are submerged for a prolonged duration, demonstrating a natural-like condition in which td neurons are activated. I assessed the roles of chemosensory receptor genes in mediating the response of td neurons to O2 and CO2. As a result, I identify Gr28b as a mediator of td responses to CO2. Deletion of Gr28 genes or RNAi knockdown of Gr28b transcripts reduce the response of td neurons to CO2. Thus, these data identify two stimuli that are detected by td neurons, and establish a putative role for Gr28b in internal chemosensation in Drosophila larvae. Finally, I present data to elucidate the neural circuitry downstream of td sensory neurons. I show that td neurons synapse directly and via relays onto neurohormone populations in the central nervous system, providing neuroanatomical basis for internal sensory neuron regulation of hormonal physiology in Drosophila. These results pave the way for future work to functionally dissect the td circuitry to understand its function in physiology and behavior.

Subjects/Keywords: Neurosciences; Drosophila; Sensory neurons; Neurobiology; Dendrites; Neural circuitry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Qian, C. S. (2018). Internal tracheal sensory neuron wiring and function in Drosophila larvae. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8FJ40QH

Chicago Manual of Style (16^th Edition):

Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Doctoral Dissertation, Columbia University. Accessed March 07, 2021. https://doi.org/10.7916/D8FJ40QH.

MLA Handbook (7^th Edition):

Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Web. 07 Mar 2021.

Vancouver:

Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2021 Mar 07]. Available from: https://doi.org/10.7916/D8FJ40QH.

Council of Science Editors:

Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8FJ40QH

University of Glasgow

23. Naim, Magda Mohamed. Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.

Degree: PhD, 1998, University of Glasgow

URL: http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697

► Neurokinin-1 receptor-immunoreactivity is present on many neurons in the spinal cord. A population of cells which possess the receptor is located in laminae III and… (more)

▼ Neurokinin-1 receptor-immunoreactivity is present on many neurons in the spinal cord. A population of cells which possess the receptor is located in laminae III and IV and these cells have dorsal dendrites that penetrate the superficial laminae (I and II) of the dorsal horn. Since the dendrites of these neurons traverse several laminae, it has been suggested that they might receive input from different classes of primary afferents that terminate in these laminae. The present study investigated the input which these cells receive from two types of primary afferents: those which contain substance P (and are thought to function as nociceptors) and those with myelinated axons that terminate in laminae III-V (most of which are low-threshold mechanoreceptors). With the immunofluorescence technique and confocal microscopy, all neurons of this type were found to receive contacts from substance P-immunoreactive varicosities and in most cases the contacts onto dorsal dendrites were very numerous. The great majority of substance P-immunoreactive varicosities which formed contacts were also calcitonin gene- related peptide-immunoreactive, indicating that they were of primary afferent origin. Combined confocal and electron microscopy revealed that synapses were present at sites of contacts between substance P-immunoreactive primary afferent boutons and the dendrites of the NK-1 receptor-immunoreactive cells. Some neurons of this type belong to the spinothalamic tract and cells retrogradely-labelled after thalamic injection of cholera toxin B subunit, were therefore examined for the presence of contacts from substance P-immunoreactive axon terminals. The results indicated that the spinothalamic tract neurons which possess the NK-1 receptor and have dorsally directed dendrites also receive contacts from substance P-immunoreactive axonal varicosities onto their dorsal dendrites. By using the transganglionic transport technique, input from myelinated primary afferents which were labelled by injection of cholera toxin B subunit into the sciatic nerve were also examined. Dual-immunofluorescence and confocal microscopy revealed the presence of contacts between labelled primary afferent terminals and all of the NK-1 receptor-immunoreactive cells examined, however these contacts were much less numerous than those which the cells received from substance P-containing primary afferents. Electron microscopy revealed that synapses were present at some of the contacts between the myelinated afferents and the NK-1 receptor-immunoreactive neurons. Since cells of this type were found to receive monosynaptic input from two different classes of primary afferents, (a major input from substance P-containing afferents and a less dense input from myelinated primary afferents) it can be concluded that they are likely to have wide-dynamic-range receptive fields but with a relatively strong nociceptive component.

Subjects/Keywords: 611; Dorsal dendrites; Immunoreactivity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Naim, M. M. (1998). Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697

Chicago Manual of Style (16^th Edition):

Naim, Magda Mohamed. “Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.” 1998. Doctoral Dissertation, University of Glasgow. Accessed March 07, 2021. http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697.

MLA Handbook (7^th Edition):

Naim, Magda Mohamed. “Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.” 1998. Web. 07 Mar 2021.

Vancouver:

Naim MM. Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. [Internet] [Doctoral dissertation]. University of Glasgow; 1998. [cited 2021 Mar 07]. Available from: http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697.

Council of Science Editors:

Naim MM. Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. [Doctoral Dissertation]. University of Glasgow; 1998. Available from: http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697

Uppsala University

24. Morát, Julia. Towards Stable Li-metal electrodefor rechargeable batteries.

Degree: Structural Chemistry, 2016, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

► Different types of alumina containing coatings were made on lithiumand copper in the purpose to mechanically hinder the growth ofdendrites. Lithium, coated with polymer-alumina… (more)

Subjects/Keywords: Lithium metal; Battery; Dendrites; light microscopy; Adiponitrile; Al2O3; Chemical Engineering; Kemiteknik

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morát, J. (2016). Towards Stable Li-metal electrodefor rechargeable batteries. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Thesis, Uppsala University. Accessed March 07, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Web. 07 Mar 2021.

Vancouver:

Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Internet] [Thesis]. Uppsala University; 2016. [cited 2021 Mar 07]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Thesis]. Uppsala University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

25. Yalamanchili, Anurag. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.

Degree: Structural Chemistry, 2014, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

►

In this thesis, the morphological changes of the anode surface in lithium sulphur cell, during early cycling, were simulated using symmetrical lithium electrode cells… (more)

Subjects/Keywords: Lithium sulphur batteries; Li anode; morphology; dendrites; pits; cycling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yalamanchili, A. (2014). Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Thesis, Uppsala University. Accessed March 07, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Web. 07 Mar 2021.

Vancouver:

Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Internet] [Thesis]. Uppsala University; 2014. [cited 2021 Mar 07]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

26. Crawford, Melissa. Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6355

► Melanocytes are specialized melanin-producing cells found in the skin, inner ear and heart. Melanocyte abnormalities cause many human disorders, including pigmentation defects, deafness, and melanoma.… (more)

▼ Melanocytes are specialized melanin-producing cells found in the skin, inner ear and heart. Melanocyte abnormalities cause many human disorders, including pigmentation defects, deafness, and melanoma. A better understanding of melanocyte biology is essential to address those disorders. Integrin-linked kinase (ILK) is a ubiquitous scaffold protein, essential for epidermal development. Importantly, the mechanisms by which ILK modulates the development and functions of melanocytic lineage cells remains unknown. To help address this void, I have developed cell-based models, as well as a reporter mouse model that allows tamoxifen-inducible Ilk gene inactivation specifically in melanocytic cells. I observed that inactivation of Ilk in first-wave melanoblasts significantly reduces their ability to form long pseudopods, migrate and proliferate. As a result, they do not populate the developing epidermis and hair follicles, normally. In post-natal melanocytes, ILK is required for proliferation and formation of cell extensions. Rac1 activation in response to growth factors, as well as Rac1-associated morphological changes in response to collagen-1 are defective in the absence of ILK. Exogenous expression of constitutive active Rac1 restores, to some degree, the formation of cell extensions. Thus, Rac1 functions downstream from ILK to regulate melanocyte morphology. Melanocytes synthesize melanin in vesicles termed melanosomes. The latter travel along microtubule tracks to the tip of dendrites, where they are then transferred to neighbouring keratinocytes. I have examined the role of ILK in melanosome trafficking and melanin transfer to keratinocytes. In the absence of ILK, melanosome trafficking is abnormal, but is partially restored following stabilization of microtubules. Thus, it is likely that the alterations in melanosome movement are due to microtubule destabilization in the absence of ILK. Furthermore, I have shown that dendrite formation and melanin transfer in response to keratinocyte-secreted factors is severely reduced in the absence of ILK. Inhibition of GSK-3 partially restored dendricity, suggesting that ILK may be required to modulate GSK-3 activity and promote dendrite formation. In summary, my data suggest key roles for ILK in establishment of the melanocyte lineage, and for postnatal melanocyte functions.

Subjects/Keywords: Integrin-linked kinase; melanoblast; melanocyte; melanosomes; dendrites; melanin transfer; Cell Biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crawford, M. (2019). Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crawford, Melissa. “Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.” 2019. Thesis, University of Western Ontario. Accessed March 07, 2021. https://ir.lib.uwo.ca/etd/6355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crawford, Melissa. “Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.” 2019. Web. 07 Mar 2021.

Vancouver:

Crawford M. Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Mar 07]. Available from: https://ir.lib.uwo.ca/etd/6355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crawford M. Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

27. Vu, Thy H. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3983

► Long-term potentiation at the distal apical dendrites of CA1 pyramidal cells. This study investigated whether a theta burst stimulation (TBS) tetanus could induce long-term potentiation… (more)

Subjects/Keywords: synaptic plasticity; hippocampus; memory formation; distal apical dendrites; CA1

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vu, T. H. (2016). Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Thesis, University of Western Ontario. Accessed March 07, 2021. https://ir.lib.uwo.ca/etd/3983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Web. 07 Mar 2021.

Vancouver:

Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Mar 07]. Available from: https://ir.lib.uwo.ca/etd/3983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

28. Francis, Chantal. Evolution of Molecular Function in Mammalian Neurons.

Degree: 2011, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/961

► A common question in neuroscience is what forms the neurological basis of the variety of behaviors in mammals. While many studies have compared mammalian anatomy… (more)

▼ A common question in neuroscience is what forms the neurological basis of the variety of behaviors in mammals. While many studies have compared mammalian anatomy and evolution, few have investigated the physiologic functions of individual neurons in a comparative manner. Neurons’ ability to modify their features in response to stimuli, known as synaptic plasticity, is fundamental for learning and memory. A key feature of synaptic plasticity involves delivering mRNA to distinct domains where they are locally translated. Regulatory coordination of these events is critical for synaptogenesis and synaptic plasticity as defects in these processes can lead to neurological diseases. In this work, we combine computational and experimental biology to investigate subcellular localization of mRNAs in dendrites of mouse and rat neurons. Differential subcellular localization of specific gene products may highlight differential synaptic function and allow the uncovering of evolutionary conserved as well as divergent molecular functions in neurons. First, we performed a comparative analysis of the dendritic transcriptome in mouse and rat via microarrays. We found that their dendritic transcriptome are significantly more divergent than other homologous tissues and that these evolutionarily changes could be associated with transposon activity. Second, we comprehensively determined subcellular expression patterns for neuronal genes in mice and rats via a systematic in situ survey on a curated list of dendritic mRNA from our previous microarray study. This survey highlighted that dendritic localization of specific transcripts occurs in a species-specific fashion. We uncovered species-specific cis and trans-elements with possible implications in transcript localization and gene expression regulation in neurons. The interactions between these elements might play a major role in the proper development and evolution of complex nervous systems. Our data will be publically available in a database (http://kim.bio.upenn.edu/insitu/public/), which could guide future investigations. Finally, we investigated single cell variability by combining microarrays, RNAseq and in situ experiments. Our preliminary results underlined the extent of this variability and its contributions in establishing cell’s unique identity. In conclusion, our study suggests the existence of species-specific mRNA localization mechanisms and supports the idea that evolution of phenotypes might be linked to the evolution of subcellular localization of transcripts.

Subjects/Keywords: mRNA; dendrites; localization; evolution; Bioinformatics; Biology; Cell Biology; Molecular Biology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Francis, C. (2011). Evolution of Molecular Function in Mammalian Neurons. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Francis, Chantal. “Evolution of Molecular Function in Mammalian Neurons.” 2011. Thesis, University of Pennsylvania. Accessed March 07, 2021. https://repository.upenn.edu/edissertations/961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Francis, Chantal. “Evolution of Molecular Function in Mammalian Neurons.” 2011. Web. 07 Mar 2021.

Vancouver:

Francis C. Evolution of Molecular Function in Mammalian Neurons. [Internet] [Thesis]. University of Pennsylvania; 2011. [cited 2021 Mar 07]. Available from: https://repository.upenn.edu/edissertations/961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Francis C. Evolution of Molecular Function in Mammalian Neurons. [Thesis]. University of Pennsylvania; 2011. Available from: https://repository.upenn.edu/edissertations/961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

29. Zhang, Ke. A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.

Degree: 2020, Florida Atlantic University

URL: http://fau.digital.flvc.org/islandora/object/fau:44463

►

Performance motor errors trigger animals’ adaptive learning behaviors to improve the accuracy and efficiency of the movement. The cerebellum is one of the key brain… (more)

Subjects/Keywords: Cerebellum; Interneurons; Purkinje cells; Dendrites; Sensorimotor integration; Neuroplasticity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, K. (2020). A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:44463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Ke. “A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.” 2020. Thesis, Florida Atlantic University. Accessed March 07, 2021. http://fau.digital.flvc.org/islandora/object/fau:44463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Ke. “A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.” 2020. Web. 07 Mar 2021.

Vancouver:

Zhang K. A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. [Internet] [Thesis]. Florida Atlantic University; 2020. [cited 2021 Mar 07]. Available from: http://fau.digital.flvc.org/islandora/object/fau:44463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang K. A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. [Thesis]. Florida Atlantic University; 2020. Available from: http://fau.digital.flvc.org/islandora/object/fau:44463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

30. Sekulic, Vladislav. Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/89679

► The hippocampus is a brain structure implicated in memory formation and spatial navigation. Understanding the structure and function of the hippocampal system is important in… (more)

▼ The hippocampus is a brain structure implicated in memory formation and spatial navigation. Understanding the structure and function of the hippocampal system is important in developing an understanding of its functioning in behaviour and neurological disease. Inhibitory interneurons in the hippocampus serve a primary role in the generation of hippocampal network rhythms which have been linked to behaviour. One type of interneuron in the hippocampal CA1 region is the oriens-lacunosum/moleculare (O-LM) cell, which forms inhibitory synapses onto local pyramidal cells. O-LM cells express hyperpolarization-activated mixed cation currents (Ih) that contribute to cellular excitability and action potential generation. Although experimental investigations have implicated Ih in the activity of O-LM cells in hippocampal activity, it is currently unknown how Ih interacts with other voltage-gated channels and synaptic inputs to shape O-LM cell output. In this thesis, I develop and use computational models of O-LM cells that are constrained by experimental recordings to study how expression and distribution of Ih allows O-LM cells to be recruited in hippocampal networks. I first find that varying dendritic distributions of Ih in O-LM cell models can equally capture electrophysiological output of O-LM cells, so long as the total membrane current due to Ih is conserved. I then show that somatic or dendritic distributions of Ih can tune O-LM cell models to participate in different network rhythms expressed in hippocampus that have been implicated in either mnemonic or emotional behaviour. Finally, I develop a new set of multi-compartment models of O-LM cells using recently acquired experimental data. These models lead to a prediction of dendritic Ih expression in the set of O-LM cells from which the recordings were obtained. My work thus represents a link in the chain of elucidating how cellular electrophysiological properties of inhibitory interneurons allow them to perform their roles in hippocampal activity. Advisors/Committee Members: Skinner, Frances K., Physiology.

Subjects/Keywords: Computational Modelling; Dendrites; HCN; Hippocampus; Interneurons; Theoretical Neuroscience; 0317

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sekulic, V. (2018). Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89679

Chicago Manual of Style (16^th Edition):

Sekulic, Vladislav. “Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.” 2018. Doctoral Dissertation, University of Toronto. Accessed March 07, 2021. http://hdl.handle.net/1807/89679.

MLA Handbook (7^th Edition):

Sekulic, Vladislav. “Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.” 2018. Web. 07 Mar 2021.

Vancouver:

Sekulic V. Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1807/89679.

Council of Science Editors:

Sekulic V. Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89679

Open Access Theses and Dissertations