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Rutgers University
1.
Hernandez, Kristina, 1985-.
The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.
Degree: PhD, Cell and Developmental Biology, 2015, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/
► Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several…
(more)
▼ Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several neurodevelopmental disorders that are characterized by alterations in dendrite branching and spine density. NOS1AP is a protein encoded by a schizophrenia susceptibility gene, and its expression is upregulated in the dorsolateral prefrontal cortex of patients with schizophrenia. Previously, our laboratory showed that NOS1AP isoforms negatively regulate dendrite branching in cultured rat hippocampal neurons. Since dendrites and spines are influenced by changes in the cytoskeleton, we investigated whether the overexpression of NOS1AP isoforms in heterologous cells alters actin and microtubule organization. Overexpression of a long isoform of NOS1AP (NOS1AP-L) increases the presence of microtubule organizing centers, whereas overexpression of the short isoform of NOS1AP (NOS1AP-S) decreases microtubule organization. Furthermore, NOS1AP isoforms associate with F-actin in rat brain and can alter actin organization in distinct ways. NOS1AP-S increases actin polymerization, and its overexpression in HEK293T cells decreases total Rac1 and cofilin protein expression. To elucidate the role of NOS1AP in spine formation and synaptic function, we overexpressed NOS1AP isoforms in cultured rat cortical neurons. Overexpression of NOS1AP-L increases the number of immature spines, whereas overexpression of NOS1AP-S increases the number of mature and immature spines. In addition, overexpression of NOS1AP-S increases the frequency of miniature excitatory postsynaptic currents (mEPSCs) but not the amplitude. Overexpression of NOS1AP-L decreases the amplitude of mEPSCs but not the frequency. To investigate whether NOS1AP-L can mediate changes to dendrite patterning in vivo, we overexpressed NOS1AP-L in neuronal progenitor cells of the embryonic rat neocortex and analyzed dendrite patterning three weeks later. Neurons overexpressing NOS1AP-L in layers II/III of the neocortex exhibit a reduction in dendrite length and number. Finally, to investigate the role that NOS1AP plays in human dendritic arbor development, human neurons were generated using induced pluripotent stem cell technology. Overexpression of either NOS1AP-L or NOS1AP-S in human neurons results in a decrease in dendrite branching. Interestingly, treatment of human neurons with D-serine results in a reduction in NOS1AP-L protein expression. Taken together, our data support a role for NOS1AP-L and NOS1AP-S in dendritogenesis and synaptic function.
Advisors/Committee Members: Firestein, Bonnie L. (chair), Tischfield, Jay A. (internal member), Moore, Jennifer C. (internal member), Hart, Ronald P. (internal member), Brzustowicz, Linda M. (internal member), Silverstein, Steve (outside member).
Subjects/Keywords: Schizophrenia; Dendrites
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APA (6th Edition):
Hernandez, Kristina, 1. (2015). The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48510/
Chicago Manual of Style (16th Edition):
Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Doctoral Dissertation, Rutgers University. Accessed March 07, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.
MLA Handbook (7th Edition):
Hernandez, Kristina, 1985-. “The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.” 2015. Web. 07 Mar 2021.
Vancouver:
Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Mar 07].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/.
Council of Science Editors:
Hernandez, Kristina 1. The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48510/

Rutgers University
2.
Patel, Mihir V., 1987-.
The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.
Degree: PhD, Neuroscience, 2018, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/
► Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its…
(more)
▼ Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its interactor, cytosolic PSD-95 interactor (cypin), regulate dendrite branching by altering microtubule dynamics. Additionally, other PSD-95 binding proteins, end-binding protein 3 (EB3) and adenomatous polyposis coli (APC), promote microtubule bundling and stabilization. Thus, PSD-95 and binding partners may regulate the dendritic arbor during development and after injury.
I first addressed the role of cypin in the brain in vivo. While generating cypin knockout mice, I identified a novel short isoform of cypin, termed cypinS, which also binds to PSD-95 and regulates dendrite branching, although an increase in dendrites occur more distal from the soma when cypinS is overexpressed compared to when cypin is overexpressed. In addition, unlike cypin, cypinS does not have guanine deaminase activity. Overexpression of cypin, but not cypinS, decreases spine density, suggestingiv that the regulation of spine density but not dendrite branching by cypin is dependent on guanine deaminase activity. Furthermore, I have uncovered novel presynaptic roles for both isoforms as overexpression of either isoform leads to increases in miniature excitatory postsynaptic current (mEPSC) frequency. Thus, cypin and cypinS, play distinct roles in neuronal development.
I then chose to study the roles of PSD-95 and interactors in recovery after traumatic brain injury (TBI). We previously identified cypin as a novel target for TBI, and thus, here I studied the role of PSD-95 and its interaction with APC or EB3 in after injury induced by in vitro and in vivo models of TBI. I show that our in vitro model of mechanical stretch injury mimics moderate injury induced by controlled cortical impact (CCI) in mice. During the early stage (1-7 days) post-moderate CCI, the interaction of PSD-95 with APC and EB3 increases. Furthermore, downregulation of PSD-95 prevents stretch-injury mediated decreases in secondary dendrite number and total dendrite length, suggesting a required role of PSD-95 in injury-mediated insults to dendrites. Thus, PSD-95 may sequester APC and EB3 from microtubules to cause decreases in dendrite branching after TBI, and PSD-95 can be targeted as a novel approach for the treatment of patients with TBI.
Advisors/Committee Members: Firestein, Bonnie L (chair), Shumyatsky, Gleb (internal member), Alder, Janet (internal member), D’Arcangelo, Gabriella (internal member), Runnels, Loren (outside member), School of Graduate Studies.
Subjects/Keywords: Dendrites; Brain damage
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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APA (6th Edition):
Patel, Mihir V., 1. (2018). The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59121/
Chicago Manual of Style (16th Edition):
Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Doctoral Dissertation, Rutgers University. Accessed March 07, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.
MLA Handbook (7th Edition):
Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Web. 07 Mar 2021.
Vancouver:
Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Mar 07].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.
Council of Science Editors:
Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Vanderbilt University
3.
Lee, Stacey Nicole.
Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.
Degree: PhD, Biological Sciences, 2016, Vanderbilt University
URL: http://hdl.handle.net/1803/12348
► Appropriate neuronal morphogenesis is essential for forming the distinct functional domains of each of the hundreds of types of neurons in the brain. Generating the…
(more)
▼ Appropriate neuronal morphogenesis is essential for forming the distinct functional domains of each of the hundreds of types of neurons in the brain. Generating the correct size and shape of
dendrites is essential for a neuron to satisfactorily sample and process the signals that converge on its dendritic field. Understanding the control of neuronal circuit development is key to understanding normal and abnormal brain function and behavior. The habenular nuclei of the limbic system regulate responses, such as anxiety, to aversive stimuli in the environment. The habenulae receive inputs from the telencephalon via elaborate
dendrites that form in the center of the nuclei. The kinase Ulk2 positively regulates dendritogenesis on habenular neurons, and in turn is negatively regulated by the cytoplasmic protein Kctd12. Given that the habenulae are a nexus in the aversive response circuit, we suspected that incomplete habenular dendritogenesis would have profound implications for behavior. We find that Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of
dendrites. Loss of Kctd12 results in increased branching/elaboration and decreased anxiety. We conclude that fine-tuning of habenular dendritogenesis during development is essential for appropriate behavioral responses to negative stimuli. In addition to dendritic shaft development, dendritic spine development is a key event in synapse formation. Dendritic spines are protrusions emanating from the dendritic shaft that interact with axons to form excitatory synapses. Here we show that spinophilin/neurabin II, a scaffolding protein that is highly expressed in dendritic spines, has an important role in dendritic spine and synapse formation in hippocampal neurons. Knockdown of endogenous spinophilin with a short hairpin RNA (shRNA) causes a significant decrease in synapse and spine density, as shown by immunostaining for the presynaptic marker synaptic vesicle protein 2 and the postsynaptic marker postsynaptic density protein 95. On the other hand, expression of mCherry-spinophilin results in an increase in spine density. These results suggest that spinophilin is critical for dendritic spine and synapse formation. We hypothesized that spinophilin was promoting dendritic spine and synapse formation by regulating F-actin accumulation. Indeed, expression of GFP-spinophilin led to an increase in the amount of F-actin in spine heads. Collectively our data demonstrate an important function for spinophilin in modulating the formation of dendritic spines and synapses.
Advisors/Committee Members: Donna Webb (committee member), Patrick Page-McCaw (committee member), Kevin Ess (committee member), Jim Patton (committee member), Douglas McMahon (Committee Chair).
Subjects/Keywords: neuroscience; dendritogenesis; dendritic spine; dendrites
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, S. N. (2016). Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12348
Chicago Manual of Style (16th Edition):
Lee, Stacey Nicole. “Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed March 07, 2021.
http://hdl.handle.net/1803/12348.
MLA Handbook (7th Edition):
Lee, Stacey Nicole. “Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons.” 2016. Web. 07 Mar 2021.
Vancouver:
Lee SN. Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1803/12348.
Council of Science Editors:
Lee SN. Kctd12 and Ulk2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/12348

Rutgers University
4.
Sweet, Eric S.
To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.
Degree: Neuroscience, 2011, Rutgers University
URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664
Subjects/Keywords: Microtubules; Dendrites
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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APA (6th Edition):
Sweet, E. S. (2011). To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. (Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Thesis, Rutgers University. Accessed March 07, 2021.
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sweet, Eric S. “To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin.” 2011. Web. 07 Mar 2021.
Vancouver:
Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Internet] [Thesis]. Rutgers University; 2011. [cited 2021 Mar 07].
Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sweet ES. To branch or not to branch: regulation of microtubules and neuronal morphology by PSD-95 and cypin. [Thesis]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000063664
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University
5.
Peng, Sheng-Shiang.
Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.
Degree: MS, Biology, 2014, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/
► The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance…
(more)
▼ The formation of a complicate nervous system requires precise navigation and elaboration for growth cone and
dendrites to connect to their target. During development, guidance molecules and receptors control the majority of the circuitry events, including promotion or inhibition of neurite growth. Semphorin 3A, a secreted Class 3 Semaphorin member, is well known for its chemorepellent function on growth cone mediated by the Neuropilin1/PlexinA4 holoreceptor complex. Recently, it has been shown to have opposite cellular responses in promoting dendrite growth and branching in mouse cortical pyramidal neurons (1, 2). However, the mechanism underlying how Semaphorin 3A/Neuropilin1/Plexin-A4 signaling regulates dendrite elaboration is unclear. Here, I have shown the importance and function of three distinct domains in the cytoplasmic region of the signaling transducing receptor of Semaphorin 3A, Plexin-A4, in regulating cortical neuron dendritic morphology. Both the C1 and H/RBD domains were found to be sufficient to trigger cortical pyramidal neuron dendrite elaboration, while the C2 domain was not necessary for
dendrites growth and branching. Using biochemical and molecular methods in combination with in vitro assays, I found and demonstrated that the Rho-GEF, FARP2 associates with PlexinA4 and mediates dendritic elaboration in primary cortical neurons following the ligand, Semaphorin 3A activation of the signaling pathway. In addition, I demonstrated that Plexin-A4 extracellular domains could interact with its co-receptor Neuropilin1, independent of the ligand Semaphorin 3A. Therefore, the extracellular Semaphorin domain may play a role in preventing Plexin-A4 activation, consistent with previous studies (3, 4). Previously, another member of the Type A Plexin receptor, Plexin-A3, was shown to play a key role in inhibiting cortical neuron dendritic spine morphogenesis in vivo (2). However, the mechanism of how Plexin-A3 signals to restrain spine formation is unknown. I have generated an array of Plexin-A3 cytoplasmic deletion mutant constructs, analogous to the Plexin-A4 deletion mutants used for this study for future studies in investigating cortical neuron dendritic spine morphology. These molecular tools that I have developed will be useful for researchers to investigate the intracellular signaling mechanisms of Semaphorin signaling in regulating neuron morphology. Taken together, my findings provide new insights to Plexin-A4 signaling, in particular, highlighting distinct intracellular domains and downstream effectors required for promoting dendritic morphology.
Advisors/Committee Members: Tran, Tracy (chair), Haspel, Gal (internal member), Maurel, Patrice (internal member).
Subjects/Keywords: Neurons – Growth; Semaphorins; Dendrites
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APA (6th Edition):
Peng, S. (2014). Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45668/
Chicago Manual of Style (16th Edition):
Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Masters Thesis, Rutgers University. Accessed March 07, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.
MLA Handbook (7th Edition):
Peng, Sheng-Shiang. “Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons.” 2014. Web. 07 Mar 2021.
Vancouver:
Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Internet] [Masters thesis]. Rutgers University; 2014. [cited 2021 Mar 07].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/.
Council of Science Editors:
Peng S. Plexin-A4 receptor regulates dendrite morphogenesis in response to Class 3 Semaphorin 3A signaling in mouse pyramidal neurons. [Masters Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45668/

Vrije Universiteit Amsterdam
6.
Groen, M.R.
Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
.
Degree: 2013, Vrije Universiteit Amsterdam
URL: http://hdl.handle.net/1871/40417
Subjects/Keywords: neuroscience;
dendrites;
development
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Groen, M. R. (2013). Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
. (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/40417
Chicago Manual of Style (16th Edition):
Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
.” 2013. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed March 07, 2021.
http://hdl.handle.net/1871/40417.
MLA Handbook (7th Edition):
Groen, M R. “Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
.” 2013. Web. 07 Mar 2021.
Vancouver:
Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
. [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1871/40417.
Council of Science Editors:
Groen MR. Dendrites: modulation and maturation of dendritic excitability and synaptic plasticity
. [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2013. Available from: http://hdl.handle.net/1871/40417

Baylor University
7.
Hamilton, Brent (Brent A.).
Asymptotic arc-components in inverse limits of dendrites.
Degree: PhD, Mathematics., 2011, Baylor University
URL: http://hdl.handle.net/2104/8216
► We study asymptotic behavior arising in inverse limit spaces of dendrites. In particular, the inverse limit is constructed with a single unimodal bonding map, for…
(more)
▼ We study asymptotic behavior arising in inverse limit spaces of
dendrites. In particular, the inverse limit is constructed with a single unimodal bonding map, for which points have unique itineraries and the critical point is periodic. Using symbolic dynamics, sufficient conditions for two rays in the inverse limit space to have asymptotic parameterizations are given. Being a topological invariant, the classification of asymptotic parameterizations would be a useful tool when determining if two spaces are homeomorphic.
Advisors/Committee Members: Raines, Brian Edward, 1975- (advisor).
Subjects/Keywords: Topology.; Continuum theory.; Inverse limits.; Dendrites.
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APA ·
Chicago ·
MLA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Hamilton, B. (. A. ). (2011). Asymptotic arc-components in inverse limits of dendrites. (Doctoral Dissertation). Baylor University. Retrieved from http://hdl.handle.net/2104/8216
Chicago Manual of Style (16th Edition):
Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites.” 2011. Doctoral Dissertation, Baylor University. Accessed March 07, 2021.
http://hdl.handle.net/2104/8216.
MLA Handbook (7th Edition):
Hamilton, Brent (Brent A ). “Asymptotic arc-components in inverse limits of dendrites.” 2011. Web. 07 Mar 2021.
Vancouver:
Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Internet] [Doctoral dissertation]. Baylor University; 2011. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2104/8216.
Council of Science Editors:
Hamilton B(A). Asymptotic arc-components in inverse limits of dendrites. [Doctoral Dissertation]. Baylor University; 2011. Available from: http://hdl.handle.net/2104/8216

Boston University
8.
Burgess, JoColl Alexis.
3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.
Degree: MS, Anatomy & Neurobiology, 2018, Boston University
URL: http://hdl.handle.net/2144/31219
► Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of…
(more)
▼ Its known that the age-related decline in cognitive facilities is not due to the loss of neurons but more subtle changes in specific areas of the brain. Structural and morphological changes in cellular alignment in the minicolumns correlate with increased prevalence of neurological diseases and in aging. In the rhesus monkey, cognitive decline is similar to what humans experience in aging. In the monkey prefrontal cortex, Brodmann area 46, an important region for executive functioning, cognitive decline correlates with changes in cellular alignment or “columnar strength” as studies by Cruz et al., (2009). Using the density maps method in Area 46, the ventral bank was identified to be the most susceptible to structural changes. Minicolumns, are defined by the cellular alignment of neurons in the cortex and some believe that the dendritic bundles of neurons in the cortex is also considered an integral part of the columns. The functional role of apical
dendrites, is not well understood, however, given the that repeated organized bundles transverse through the laminae could be further support for their inclusion in minicolumns with possible functional importance. If structural changes such as loss of columnar strength (neuronal displacement) that correlates with cognitive aging, it is possible that the dendritic organization may also be affected in this area. In this thesis, it is hypothesized that the dendritic bundles in this area could also be related to the cognitive deficits associated with normal aging. Using double- fluorescence labeling for
dendrites (MAP-2) and neurons (Neu-N), 3D confocal reconstructions of the dorsal and ventral banks of Area 46 were used to investigate structural/morphological changes in the dendritic bundles in young and old rhesus monkeys. While cortical thickness and apical dendritic length between both banks did not change, we found a significant increase in inter-bundle spacing at layer 6A in the older monkeys in the ventral bank. Inter-bundle spacing for bundles in layer 5 was measured and showed that the young consistently have smaller inter-bundle spacing. Future studies with larger sample size will also investigate whether changes in dendritic bundles and their organization also correlate with age-related cognitive deficits.
Advisors/Committee Members: Zumwalt, Ann C. (advisor).
Subjects/Keywords: Neurosciences; Minicolumns; Monkeys; Area 46; Apical dendrites
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Burgess, J. A. (2018). 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/31219
Chicago Manual of Style (16th Edition):
Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Masters Thesis, Boston University. Accessed March 07, 2021.
http://hdl.handle.net/2144/31219.
MLA Handbook (7th Edition):
Burgess, JoColl Alexis. “3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey.” 2018. Web. 07 Mar 2021.
Vancouver:
Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2144/31219.
Council of Science Editors:
Burgess JA. 3D analysis of apical dendritic organization in the prefrontal cortex of young and old monkey. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/31219

George Mason University
9.
Rubaharan, Myurajan.
Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
.
Degree: 2014, George Mason University
URL: http://hdl.handle.net/1920/9111
► Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional nervous system. Dendrites,…
(more)
▼ Dendrite morphogenesis represents a critical process in the establishment, maintenance and modulation of neural connectivity that is the basis of a functional
nervous system.
Dendrites, as the primary sites of synaptic and/or sensory input largely
determine the size and nature of the neuronal receptive field. The Drosophila melanogaster peripheral nervous system (PNS) has emerged as an excellent model system for studying molecular mechanisms underlying class specific dendrite
development. Dendritic arborization (da) neurons are grouped into four distinct classes (I-
IV) based upon increasing orders of dendritic complexity (Grueber et al., 2002). A recent study has identified dar1, a Krüppel-like transcription factor, as an essential regulator involved in controlling dendrite development and growth via microtubule modulation (Ye et al., 2011). Interestingly, at the embryonic stage Dar1 protein exhibits nuclear localization in all da neuron subclasses, however at the third instar larval stage of
development, Dar1 exhibits a subcellular shift towards class-specific differential
localization. Specifically, Dar1 is primarily nuclear in the morphologically simple class I
neurons, in contrast to largely cytoplasmic localization in the highly complex class IV da neurons. This observation led us to investigate putative protein interaction partners of
Dar1 that potentially regulate this class specific differential localization, and the result of perturbing this localization. We conducted a pilot RNAi screen of putative Dar1-
interacting proteins to investigate their potential mechanistic role(s) in dendrite development and Dar1 differential localization in class IV da neurons. From this pilot
screen, we identified the CBP/p300 homolog nejire (nej) as a novel regulator of dendritic
development that also modulates Dar1 subcellular localization. We have conducted
detailed structure-function studies using domain-specific deletions of nej that have
provided further insights into the specific role of different protein domains in mediating distinct aspects of dendritic growth. Furthermore, we have used these domain-specific deletion constructs to elucidate the interaction between Dar1 and Nej. Collectively, these analyses contribute to our understanding of molecular mechanisms of combinatorial
transcription factor activity at a class-specific level and how this regulation contributes to
specification of distinct neuronal morphologies that underlie the establishment of complex neural networks.
Advisors/Committee Members: Cox, Daniel N (advisor).
Subjects/Keywords: dendrites;
neuron;
Drosophila;
transcription factor;
Nejire;
Dar1
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Rubaharan, M. (2014). Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
. (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/9111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
.” 2014. Thesis, George Mason University. Accessed March 07, 2021.
http://hdl.handle.net/1920/9111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rubaharan, Myurajan. “Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
.” 2014. Web. 07 Mar 2021.
Vancouver:
Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
. [Internet] [Thesis]. George Mason University; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1920/9111.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rubaharan M. Nejire, a CBP/p300 Family Transcription Factor, Regulates Dendritic Development by Modulating the Localization of the Krüppel-like Transcription Factor Dar1 in Drosophila Sensory Neurons
. [Thesis]. George Mason University; 2014. Available from: http://hdl.handle.net/1920/9111
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University
10.
Lee, Kuo-Sheng.
MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.
Degree: 2019, Florida Atlantic University
URL: http://fau.digital.flvc.org/islandora/object/fau:41947
► The physical architecture of neural circuits is thought to underlie the computations that give rise to higher order feature sensitivity in the neocortex. Recent technological…
(more)
▼ The physical architecture of neural circuits is thought to underlie the computations that give rise to higher order feature sensitivity in the neocortex. Recent technological breakthroughs have allowed the structural and functional investigation of the basic computational units of neural circuits; individual synaptic connections. However, it remains unclear how cortical neurons sample and integrate the thousands of synaptic inputs, supplied by different brain structures, to achieve feature selectivity. Here, I first describe how visual cortical circuits transform the elementary inputs supplied by the periphery into highly diverse, but well-organized, feature representations. By combining and optimizing newly developed techniques to map the functional synaptic connections with defined sources of inputs, I show that the intersection between columnar architecture and dendritic sampling strategies can lead to the selectivity properties of individual neurons: First, in the canonical feedforward circuit, the basal dendrites of a pyramidal neuron utilize unique strategies to sample ON (light increment) and OFF (light decrement) inputs in orientation columns to create the distinctive receptive field structure that is responsible for basic sensitivity to visual spatial location, orientation, spatial frequency, and phase. Second, for long-range horizontal connections, apical dendrites unbiasedly integrate functionally specialized and spatially targeted inputs in different orientation columns, which generates specific axial surround modulation of the receptive field.
2019
Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2019.
Collection: FAU
Advisors/Committee Members: Fitzpatrick, David (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences.
Subjects/Keywords: Neocortex; Visual Cortex – physiology; Neural circuitry; Dendrites
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, K. (2019). MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:41947
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lee, Kuo-Sheng. “MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.” 2019. Thesis, Florida Atlantic University. Accessed March 07, 2021.
http://fau.digital.flvc.org/islandora/object/fau:41947.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lee, Kuo-Sheng. “MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS.” 2019. Web. 07 Mar 2021.
Vancouver:
Lee K. MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. [Internet] [Thesis]. Florida Atlantic University; 2019. [cited 2021 Mar 07].
Available from: http://fau.digital.flvc.org/islandora/object/fau:41947.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lee K. MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNS. [Thesis]. Florida Atlantic University; 2019. Available from: http://fau.digital.flvc.org/islandora/object/fau:41947
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology
11.
Mul, M.M. (author).
Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.
Degree: 2014, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039
► A three-dimensional mixed-mode cellular automaton model [C. Bos, M. G. Mecozzi, and J. Sietsma. Computational Materials Science 48.3 (2010): 692-699] for the austenite to ferrite…
(more)
▼ A three-dimensional mixed-mode cellular automaton model [C. Bos, M. G. Mecozzi, and J. Sietsma. Computational Materials Science 48.3 (2010): 692-699] for the austenite to ferrite transformation in low-carbon steel has been analyzed and improved. A comparison between the new and conventional model has been made and the improvements found are significant. Interface velocity is based on diffusion of carbon atoms and determined by the local density of carbon. A higher grain boundary carbon diffusion coefficient is applied. The conventional model has been revised and stabilized. Real dilatometry tests have been used to mirror the transformation behaviour of the model with reality. For a one-dimensional model it has been shown that the space-discretizing cellular automaton model converges to the space-continuous method of Murray-Landis.
Applied Mathematics
Numerical Analysis
Electrical Engineering, Mathematics and Computer Science
Advisors/Committee Members: Vermolen, F.J. (mentor), Bos, C. (mentor), Vuik, C. (mentor).
Subjects/Keywords: phase transformation; cellular automaton; steel alloy; dendrites
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mul, M. M. (. (2014). Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039
Chicago Manual of Style (16th Edition):
Mul, M M (author). “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.” 2014. Masters Thesis, Delft University of Technology. Accessed March 07, 2021.
http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.
MLA Handbook (7th Edition):
Mul, M M (author). “Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability.” 2014. Web. 07 Mar 2021.
Vancouver:
Mul MM(. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. [Internet] [Masters thesis]. Delft University of Technology; 2014. [cited 2021 Mar 07].
Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039.
Council of Science Editors:
Mul MM(. Modeling the Austenite Ferrite Transformation by Cellular Automaton: Improving Interface Stability. [Masters Thesis]. Delft University of Technology; 2014. Available from: http://resolver.tudelft.nl/uuid:31e2ec84-2c4c-45a4-b7ae-06e81303e039
12.
Ikpegbu, Ekele.
Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.
Degree: PhD, 2018, University of Edinburgh
URL: http://hdl.handle.net/1842/31361
► Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In…
(more)
▼ Fibroblast growth factor 2 (FGF-2) is known to be released from cartilage upon injury and is able to influence chondrocyte gene expression in vitro. In cartilage, FGF-2 regulates E11/podoplanin expression in murine joints following surgical destabilisation (DMM model of osteoarthritis (OA)), and in cartilage explant injury models. In bone, E11 is critical for the early stages of osteocytogenesis and is responsible for the acquisition of the osteocyte dendritic phenotype. This dendritic phenotype is dysregulated in OA and given the known role of the osteocyte in controlling bone remodelling, this may contribute to the subchondral bone thickening observed in OA. Hence, the aim of this study was to elucidate the nature of FGF-2- mediated E11 expression and osteocytogenesis in skeletal health and disease. This thesis has shown that FGF-2 dose-dependently increased E11 mRNA expression in MC3T3 cells, primary osteoblasts and in primary calvaria organ cultures, which was confirmed by E11 protein western blotting data. The FGF-2 induced changes in E11 expression were accompanied by significant increases in the mRNA expression of the osteocyte markers Phex and Dmp1, and significant decreases in the mRNA expression of the osteoblast markers Col1a1, Postn, Bglap and Alpl expression. This thus supports the hypothesis that FGF-2 drives osteocytogenesis. The acquisition of osteocyte phenotype involves the re-organisation of the cytoskeleton, such as F-actin. This step is important for the transition of cuboidal-shaped osteoblasts to the stellate-shaped osteocyte phenotype. FGF-2 stimulation of MC3T3 cells and primary osteoblasts revealed more numerous and longer dendrites, as visualised by phalloidin staining for F-actin and indicative of the acquisition of the osteocyte phenotype. In contrast, control cells had a typical rounded morphology with fewer and shorter dendrites. Furthermore, immunofluorescence labelling for E11 in control cells revealed uniform distribution throughout the cytoplasm, especially in the perinuclear region. In contrast, FGF-2 treated cells showed a modified distribution where E11 was negligible in the cytoplasm, but concentrated in the dendrites. The use of siRNA knockdown of E11 achieved a 70% reduction of basal E11 mRNA expression. This knockdown also effectively abrogated FGF-2-related changes in E11 expression and dendrite formation as disclosed by mRNA and protein expression, immunofluorescence and F-actin staining with phalloidin. Despite these FGF-2 driven increases in E11 and osteocyte dendrite formation in vitro, immunohistochemical labelling revealed no differences in E11 expression in subchondral, trabecular and cortical osteocytes from naïve Fgf-2 deficient mice in comparison to wild-type mice. Similar results were observed upon sclerostin immunolabelling. FGF-2 stimulation of MC3T3 cells elicited activation of ERK1/2, Akt and p38 MAPK. However, inhibition of the aforementioned pathways failed to reduce FGF-2- mediated E11 expression and as such, the specific signalling pathway responsible…
Subjects/Keywords: 616.7; osteoblasts; osteocyte; dendrites; E11; FGF-2
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ikpegbu, E. (2018). Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/31361
Chicago Manual of Style (16th Edition):
Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed March 07, 2021.
http://hdl.handle.net/1842/31361.
MLA Handbook (7th Edition):
Ikpegbu, Ekele. “Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease.” 2018. Web. 07 Mar 2021.
Vancouver:
Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1842/31361.
Council of Science Editors:
Ikpegbu E. Effects of FGF-2 on E11-mediated osteocytogenesis in skeletal health and disease. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/31361

Indiana University
13.
Chew, Cory Charles.
EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
.
Degree: 2020, Indiana University
URL: http://hdl.handle.net/2022/26089
► Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. It has been previously demonstrated that partial…
(more)
▼ Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. It has been previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and that treatment with testosterone attenuates these structural and functional deficits. In this dissertation, I establish that exercise following partial motoneuron depletion is similarly neuroprotective to motoneurons, via a mechanism that requires androgen receptor activation at the target muscle of the affected motoneurons. I also establish that exercise transiently upregulates both circulating concentrations of testosterone and the density of androgen receptors in quadriceps musculature. Finally, I demonstrate that prior training with exercise is not able to confer resilience to subsequent neural injury, but that exercise may confer androgen sensitivity to a previously insensitive neuromuscular system. The findings in this dissertation demonstrate that exercise is neuroprotective to motoneurons via the same mechanism of androgen receptor activation in the target muscle seen with supplemental hormone treatment, and that a behavioral intervention such as exercise can have modulatory effects on both peripheral and central aspects of the neuromuscular complex.
Advisors/Committee Members: Sengelaub, Dale (advisor).
Subjects/Keywords: Exercise;
Androgens;
Motoneurons;
Dendrites;
Neuroprotection;
Hormones
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chew, C. C. (2020). EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
. (Thesis). Indiana University. Retrieved from http://hdl.handle.net/2022/26089
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chew, Cory Charles. “EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
.” 2020. Thesis, Indiana University. Accessed March 07, 2021.
http://hdl.handle.net/2022/26089.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chew, Cory Charles. “EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
.” 2020. Web. 07 Mar 2021.
Vancouver:
Chew CC. EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
. [Internet] [Thesis]. Indiana University; 2020. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2022/26089.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chew CC. EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
. [Thesis]. Indiana University; 2020. Available from: http://hdl.handle.net/2022/26089
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Guinaudeau, Ophélie.
Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.
Degree: Docteur es, Informatique, 2019, Université Côte d'Azur (ComUE)
URL: http://www.theses.fr/2019AZUR4001
► Les neurones biologiques communiquent par le biais d’impulsions électriques, appelées spikes, et les fonctions cérébrales émergent notamment de la coordination entre les réceptions et émissions…
(more)
▼ Les neurones biologiques communiquent par le biais d’impulsions électriques, appelées spikes, et les fonctions cérébrales émergent notamment de la coordination entre les réceptions et émissions de ces spikes. Par ailleurs, il est largement admis que la fonction de chaque neurone dépend de sa morphologie. Les dendrites conditionnent l’intégration spatio-temporelle des spikes reçus et influent sur les temps d’occurrence des spikes émis. Elles sont donc fondamentales pour l’étude in silico des mécanismes de coordination, et en particulier pour l’étude des assemblées de neurones. Les modèles de neurones existants prenant en compte les dendrites, sont généralement des modèles mathématiques détaillés, souvent à base d’équations différentielles, dont la simulation nécessite des ressources de calculs importantes. De plus, leur complexité intrinsèque rend difficile l’analyse et les preuves sur ces modèles. Dans cette thèse, nous proposons un modèle de neurone intégrant des dendrites d’une manière abstraite. Dans l’objectif d’ouvrir la porte aux méthodes formelles, nous établissons une définition rigoureuse du cadre de modélisation et mettons en évidence des propriétés algébriques remarquables de l’intégration dendritique. Nous avons notamment démontré qu’il est possible de réduire la structure d’un neurone en préservant sa fonction d’entrée/sortie. Nous avons ainsi révélé des classes d’équivalence dont nous savons déterminer un représentant canonique. En s’appuyant sur la théorie des catégories et par des morphismes de neurones judicieusement définis, nous avons ensuite analysé plus finement ces classes d’équivalence. Un résultat surprenant découle de ces propriétés : un simple ajout de délais dans les modèles informatiques de neurones permet de prendre en compte une intégration dendritique abstraite, sans représenter explicitement la structure arborescente des dendrites. À la racine de l’arborescence dendritique, la modélisation du soma contient inévitablement une équation différentielle lorsque l’on souhaite préserver l’essence du fonctionnement biologique. Ceci impose de combiner une vision analytique avec la vision algébrique. Néanmoins, grâce à une étape préalable de discrétisation temporelle, nous avons également implémenté un neurone complet en Lustre qui est un langage formel autorisant des preuves par model checking. Globalement, nous apportons dans cette thèse un premier pas encourageant vers une formalisation complète des neurones, avec des propriétés remarquables sur l’intégration dendritique.
Biological neurons communicate by means of electrical impulses, called spikes. Brain functions emerge notably from reception and emission coordination between those spikes. Furthermore, it is widely accepted that the function of each neuron depends on its morphology. In particular, dendrites perform the spatio-temporal integration of received spikes and affect the occurrence of emitted spikes. Dendrites are therefore fundamental for in…
Advisors/Committee Members: Bernot, Gilles (thesis director).
Subjects/Keywords: Modélisation formelle; Neurone; Dendrites; Propiétés algébriques; Délais; Lustre; Formal modelling; Neuron; Dendrites; Algebraic properties; Delays; Lustre
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Guinaudeau, O. (2019). Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. (Doctoral Dissertation). Université Côte d'Azur (ComUE). Retrieved from http://www.theses.fr/2019AZUR4001
Chicago Manual of Style (16th Edition):
Guinaudeau, Ophélie. “Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.” 2019. Doctoral Dissertation, Université Côte d'Azur (ComUE). Accessed March 07, 2021.
http://www.theses.fr/2019AZUR4001.
MLA Handbook (7th Edition):
Guinaudeau, Ophélie. “Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties.” 2019. Web. 07 Mar 2021.
Vancouver:
Guinaudeau O. Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. [Internet] [Doctoral dissertation]. Université Côte d'Azur (ComUE); 2019. [cited 2021 Mar 07].
Available from: http://www.theses.fr/2019AZUR4001.
Council of Science Editors:
Guinaudeau O. Neurone abstrait : une formalisation de l’intégration dendritique et ses propriétés algébriques : Abstract neuron : formalizing dendritic integration and algebraic properties. [Doctoral Dissertation]. Université Côte d'Azur (ComUE); 2019. Available from: http://www.theses.fr/2019AZUR4001

University of Utah
15.
Newby, Jay.
Molecular motor-based models of random intermittent search in dendrites.
Degree: PhD, Mathematics;, 2010, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787
► A key component in the cellular mechanisms underlying learning and memory involves the distribution and delivery of mRNA to synaptic sites in dendrites. A minimal…
(more)
▼ A key component in the cellular mechanisms underlying learning and memory involves the distribution and delivery of mRNA to synaptic sites in dendrites. A minimal three-state random intermittent search model of motor-driven mRNA transport is developed to explore the question of why motor-driven mRNA are observed moving bidirectionally. The model is analyzed by College of Engineering; the probability an mRNA is delivered to a synaptic target and the average delivery time (MFPT). It is found that if the branched geometry of the dendrite is ignored, a purely unidirectional transport strategy will result in the smallest MFPT at any given delivery probability. The branched geometry of the dendrite is then incorporated into the model, and it is shown that a phase transition exists for a critical delivery probability where bidirectional strategies improve the corresponding MFPT. To further explore the impact of motor-driven transport behavior on mRNA delivery, the three-state model is extended to include a detailed, biophysical model of a multimotor complex coordinated through a tug-of-war. The model is analyzed to explore how various measurable, physical quantities, such as adenosine triphosphate, can be tuned to optimize cargo delivery.
Subjects/Keywords: Dendrites; Intracellular transport; Jump velocity; Molecular motors; MRNA transport; Random search
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Newby, J. (2010). Molecular motor-based models of random intermittent search in dendrites. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787
Chicago Manual of Style (16th Edition):
Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Doctoral Dissertation, University of Utah. Accessed March 07, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.
MLA Handbook (7th Edition):
Newby, Jay. “Molecular motor-based models of random intermittent search in dendrites.” 2010. Web. 07 Mar 2021.
Vancouver:
Newby J. Molecular motor-based models of random intermittent search in dendrites. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Mar 07].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787.
Council of Science Editors:
Newby J. Molecular motor-based models of random intermittent search in dendrites. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/606/rec/787

University of Alberta
16.
Kim, Hojeong.
Biophysics underlying bistable neurons with branching
dendrites.
Degree: PhD, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/fq977w125
► The goal of this thesis is to investigate the biophysical basis underlying the nonlinear relationship between firing response and current stimulation in single motor neurons.…
(more)
▼ The goal of this thesis is to investigate the
biophysical basis underlying the nonlinear relationship between
firing response and current stimulation in single motor neurons.
After reviewing the relevant motoneuron physiology and theories
that describe complex dendritic signaling properties, I hypothesize
that at least five passive electrical properties must be considered
to better understand the physiological input-output properties of
motor neurons in vivo: input resistance, system time constant, and
three signal propagation properties between the soma and dendrites
that depend on the signal direction (i.e. soma to dendrites or vice
versa) and type (i.e. direct (DC) or alternating (AC) current). To
test my hypothesis, I begin with characterizing the signal
propagation of the dendrites, by directly measuring voltage
attenuations along the path of dendrites of the type-identified
anatomical neuron models. Based on this characterization of
dendritic signaling, I develop the novel realistic reduced modeling
approach by which the complex geometry and passive electrical
properties of anatomically reconstructed dendrites can be
analytically mapped into simple two-compartment modeling domain
without any restrictive assumptions. Combining mathematical
analysis and computer simulations of my new reduced model, I show
how individual biophysical properties (system input resistance,
time constant and dendritic signaling) contribute to the local
excitability of the dendrites, which plays an essential role in
activating the plateau generating membrane mechanisms and
subsequent nonlinear input-output relations in a single neuron. The
biophysical theories and computer simulations in this thesis are
primarily applied to motor neurons that compose the motor neuron
pool for control of movement. However, the general features of the
new reduced neuron modeling approach and important insights into
neuronal computations are not limited to this area. My findings can
be extended to other areas including artificial neural networks
consisting of single compartment processors.
Subjects/Keywords: Dendrites; Neuron; Direction dependent voltage attenuation; Reduced modeling; Bistable firing behaviour
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Kim, H. (2011). Biophysics underlying bistable neurons with branching
dendrites. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/fq977w125
Chicago Manual of Style (16th Edition):
Kim, Hojeong. “Biophysics underlying bistable neurons with branching
dendrites.” 2011. Doctoral Dissertation, University of Alberta. Accessed March 07, 2021.
https://era.library.ualberta.ca/files/fq977w125.
MLA Handbook (7th Edition):
Kim, Hojeong. “Biophysics underlying bistable neurons with branching
dendrites.” 2011. Web. 07 Mar 2021.
Vancouver:
Kim H. Biophysics underlying bistable neurons with branching
dendrites. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Mar 07].
Available from: https://era.library.ualberta.ca/files/fq977w125.
Council of Science Editors:
Kim H. Biophysics underlying bistable neurons with branching
dendrites. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/fq977w125

Cornell University
17.
Kishore, Sandeep.
The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.
Degree: PhD, Neurobiology, 2011, Cornell University
URL: http://hdl.handle.net/1813/33616
► The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that…
(more)
▼ The work described here focuses on novel patterns of motoneuron dendritic organization and dendritic development in relation to the recruitment patterns of spinal motoneurons that drive swimming in larval zebrafish. I first looked at the dendritic organization of motoneurons in freely swimming fish and tracked its emergence in relation to the maturation of locomotor behavior. I used transient expression of fluorescent proteins to visualize the dendritic structure of motoneurons in zebrafish larvae at a stage when they have been swimming freely for a few days. My work showed that there is a dendritic topography related to the recruitment of motoneurons at different locomotor speeds that emerges by the time fish first begin to swim, and is maintained even as
dendrites grow after the onset of spontaneous swimming. Since neuronal activity is thought to influence dendritic structure, I then studied the structural dynamics of dendritic arbors of individual motoneurons in larval zebrafish soon after they begin swimming. I found a systematic relationship between the location of a spinal motoneuron and the dynamics of its dendritic arbor - youngest, ventral motoneurons are least dynamic whereas increasingly older and more dorsal motoneurons are more dynamic. This is contrary to the idea that
dendrites of younger neurons are more dynamic than
dendrites of older neurons because younger ones are growing more. I then asked if this pattern of dendritic dynamics is related to the systematic variation of excitability of motoneurons described recently. I tested this possibility genetically by expressing Kir2.1 to suppress excitability of individual motoneurons. This led to a dramatic increase in the dynamics of ventral motoneurons, which became more dynamic than more dorsal ones. My results suggest that a naturally occurring dorsoventral gradient of excitability may contribute to the variation in dendritic dynamics. The patterns of dendritic organization and development I describe may also be applicable to other interneuron types in the spinal cord and hindbrain.
Advisors/Committee Members: Fetcho, Joseph R. (chair), Deitcher, David Lawrence (committee member), Harris-Warrick, Ronald Morgan (committee member).
Subjects/Keywords: Dendrites; Motoneurons; Zebrafish; Development; Filopodia; Imaging; Motor networks
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kishore, S. (2011). The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/33616
Chicago Manual of Style (16th Edition):
Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.” 2011. Doctoral Dissertation, Cornell University. Accessed March 07, 2021.
http://hdl.handle.net/1813/33616.
MLA Handbook (7th Edition):
Kishore, Sandeep. “The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish.” 2011. Web. 07 Mar 2021.
Vancouver:
Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1813/33616.
Council of Science Editors:
Kishore S. The Development And Organization Of Dendrites Of Motoneurons In Larval Zebrafish. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33616

Cornell University
18.
Tu, Zhengyuan.
STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.
Degree: PhD, Materials Science and Engineering, 2018, Cornell University
URL: http://hdl.handle.net/1813/59396
► Significant advances in the amount of electrical energy that can be stored in electrochemical cells, such as rechargeable batteries require the adoption of high energy…
(more)
▼ Significant advances in the amount of electrical energy that can be stored in electrochemical cells, such as rechargeable batteries require the adoption of high energy metallic anodes including Li, Na, Al, Zn, etc. Such anodes introduce as significant technical challenges because they are known to form rough electrodeposits, loosely termed
dendrites, during the device operation. This produces irreversible active material (electrode and electrolyte) losses during normal cell operation and poses safety concerns because the
dendrites can proliferate in the inter-electrode space, shorting the cell internally. Though similar phenomenon has been investigated in the more conventional context of metal electroplating, more complex effects can dominate in a battery configuration especially at current densities below the limiting current and in cells where the metal anodes undergo chemical reaction with electrolyte components. In this thesis, a comprehensive materials strategy involving structural and interfacial engineering is pursued to stabilize lithium metal electrodeposition. The strategy is based on guidelines defined by a theoretical linear stability analysis of metal electrodeposition in structured electrolytes. The origin of deposition instability is revealed to involve fundamental features of electrolytes and interfaces near metal anodes, which lead to electro- convective, morphological and chemical instability. I show that the first two instabilities can be addressed by using a nanostructured polymer/ceramic hybrid electrolyte, which exhibits high conductivity, high modulus and the ability to rectify ion transport through confinement. The well-defined nanoporous structure of the electrolytes also confine the length scale of the electrodeposit, which allows surface tension and other weaker forces at the interface to flatten rough electrodeposits, promoting dendrite-free operation. The chemical instability poses a more serious challenge because it is intrinsic to the chemistry of the electrode and electrolyte components; any exposure of one to the other can in principle drive a reaction cascade that ends in unconstrained growth in the cell impedance and premature failure. I show that this challenge can be overcome by the careful design of solid electrolyte interphases (SEIs) that regulate mass transport of reactive electrolyte ingredients and at the same time are able to flex to accommodate volume expansion of the anode. A significant finding is that these features can be realized using electrolyte additives designed to selectively break-down in-situ to form SEI with explicit composition set by the chemistry of the additive. A particularly important example are additives that break down to form halogen salts, which exhibit low surface diffusion barrier and fast interfacial transport. Such materials are shown to be highly effective in improve battery cycle lifetime. A second category of SEI explored in the study are so- called artificial SEI formed by pretreating the metallic electrode with polymer, metals, and metal…
Advisors/Committee Members: Archer, Lynden A. (chair), Wiesner, Ulrich B. (committee member), Kourkoutis, Lena Fitting (committee member).
Subjects/Keywords: dendrites; Energy; Materials Science; alkali metals; lithium batteries; rechargeable batteries; electrodeposition
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tu, Z. (2018). STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/59396
Chicago Manual of Style (16th Edition):
Tu, Zhengyuan. “STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.” 2018. Doctoral Dissertation, Cornell University. Accessed March 07, 2021.
http://hdl.handle.net/1813/59396.
MLA Handbook (7th Edition):
Tu, Zhengyuan. “STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES.” 2018. Web. 07 Mar 2021.
Vancouver:
Tu Z. STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. [Internet] [Doctoral dissertation]. Cornell University; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1813/59396.
Council of Science Editors:
Tu Z. STABILIZING ALKALI METAL ELECTRODEPOSITION VIA NANOSTRUCTURED HYBRID ELECTROLYTE AND INTERPHASE DESIGN FOR RECHARGEABLE METAL BASED BATTERIES. [Doctoral Dissertation]. Cornell University; 2018. Available from: http://hdl.handle.net/1813/59396

Purdue University
19.
Schartz, Nicole Denise.
A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.
Degree: MS, Psychological Sciences, 2016, Purdue University
URL: https://docs.lib.purdue.edu/open_access_theses/1135
► Status epilepticus (SE) triggers pathological changes to hippocampal dendrites that may promote epileptogenesis. The microtubule associated protein 2 (Map2) helps stabilize microtubules of the dendritic…
(more)
▼ Status epilepticus (SE) triggers pathological changes to hippocampal
dendrites that may promote epileptogenesis. The microtubule associated protein 2 (Map2) helps stabilize microtubules of the dendritic cytoskeleton. Recently, we reported a substantial decline in Map2 that coincided with robust microglia accumulation in the CA1 hippocampal region after an episode of SE. A spatial correlation between Map2 loss and reactive microglia was also reported in human cortex from refractory epilepsy. New evidence supports that microglia are guided by proteins of the classical complement pathway (C1q and C3) to prune dendritic structures. Furthermore, components of complement have been shown to be upregulated in human and experimental epilepsy. Thus, to identify a potential role of the classical complement pathway in SE-induced Map2 and microglial changes, we characterized the spatiotemporal profile of these events. We used immunohistochemistry to determine the distribution of Map2 and the microglia marker IBA1 in the hippocampus after pilocarpine-induced SE from 4 hours to 35 days. We found a decline in Map2 immunoreactivity in the CA1 area that reached minimal levels at 14 days post-SE and partially increased thereafter. In contrast, maximal microglia accumulation occurred in the CA1 area at 14 days post-SE. We then mapped the spatiotemporal profile of C1q using immunohistochemistry at 3-35 days after SE, where substantial Map2 and microglial alterations were observed. We used western blot to determine the levels of C3 and its cleavage products. C1q and C3 were both increased in the hippocampus at 14 days after SE, when Map2 and microglia changes were most profound. Our data indicate that SE-induced Map2 and microglial changes parallel each other’s spatiotemporal profiles. These findings also suggest a potential role for the classical complement pathway in SE-induced Map2-microglial interactions.
Advisors/Committee Members: Amy L Brewster, Christie Sahley, Susan Sangha, Kimberly Kinzig.
Subjects/Keywords: behavioral models; classical complement; dendrites; hippocampus; microglia; temporal lobe epilepsy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Schartz, N. D. (2016). A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. (Thesis). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_theses/1135
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schartz, Nicole Denise. “A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.” 2016. Thesis, Purdue University. Accessed March 07, 2021.
https://docs.lib.purdue.edu/open_access_theses/1135.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schartz, Nicole Denise. “A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy.” 2016. Web. 07 Mar 2021.
Vancouver:
Schartz ND. A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. [Internet] [Thesis]. Purdue University; 2016. [cited 2021 Mar 07].
Available from: https://docs.lib.purdue.edu/open_access_theses/1135.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schartz ND. A role for the classical complement pathway in hippocampal dendritic injury and hippocampal dependent memory deficits in a model of acquired epilepsy. [Thesis]. Purdue University; 2016. Available from: https://docs.lib.purdue.edu/open_access_theses/1135
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto
20.
Guet-McCreight, Alexandre Thomas Liam.
Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.
Degree: 2015, University of Toronto
URL: http://hdl.handle.net/1807/70331
► In hippocampus, interneuron specific 3 (IS3) cells have been shown to make inhibitory synapses onto specific types of inhibitory interneuron dendrites with the ability to…
(more)
▼ In hippocampus, interneuron specific 3 (IS3) cells have been shown to make inhibitory synapses onto specific types of inhibitory interneuron dendrites with the ability to control their firing patterns. Morphological and synaptic aspects of IS3 cells are being examined, but what type, how much and where voltage-gated channels (VGCs) are present on IS3 cells has not been determined. Using a combination of the NEURON and MATLAB software environments, we have developed an approach that uses experimental IS3 data to generate databases of multi-compartment models that show appropriate activity for IS3 cells. Given their correspondence with data, our models predict relative conductance balances and distributions of different channel types in IS3 cells and can be used as a basis for understanding the functional roles of IS3 cells in hippocampus, a central structure in memory formation.
M.Sc.
Advisors/Committee Members: Skinner, Frances K, Physiology.
Subjects/Keywords: Computational Neuroscience; Dendrites; Multi-Compartment Modeling; Voltage-Gated Channels; 0317
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Guet-McCreight, A. T. L. (2015). Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70331
Chicago Manual of Style (16th Edition):
Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Masters Thesis, University of Toronto. Accessed March 07, 2021.
http://hdl.handle.net/1807/70331.
MLA Handbook (7th Edition):
Guet-McCreight, Alexandre Thomas Liam. “Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus.” 2015. Web. 07 Mar 2021.
Vancouver:
Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1807/70331.
Council of Science Editors:
Guet-McCreight ATL. Predicting Cell-type Specific Active Properties by Developing Multi-compartment Models using Databases and Electrophysiological Feature Constraints: Application to Interneuron Specific 3 (IS3) Cells in the Hippocampus. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70331

Columbia University
21.
Vaadia, Rebecca Danielle.
Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.
Degree: 2020, Columbia University
URL: https://doi.org/10.7916/d8-9f48-0354
► A neuron’s function depends critically on the shape, size, and territory of its dendritic field. We have only recently begun to understand how diverse dendritic…
(more)
▼ A neuron’s function depends critically on the shape, size, and territory of its dendritic field. We have only recently begun to understand how diverse dendritic arbors are built and how the morphology and territory of these arbors support diverse neural functions. In this thesis, I use the Drosophila larval peripheral nervous system (PNS) as a model for studying these questions, as these neurons are very amenable to genetic manipulation and in vivo imaging.
First, I examined the relationship between dendritic fields and sensory activity in the proprioceptive neurons of the body wall. In collaboration with Elizabeth Hillman’s lab, we used a high-speed volumetric microscopy technique, Swept Confocally Aligned Planar Excitation (SCAPE) microscopy, to simultaneously image the dendrite deformation dynamics and sensory activity of body wall neurons in crawling Drosophila larvae. We imaged a set of proprioceptive neurons with diverse dendrite morphologies and territories, revealing that each neuron subtype responds in sequence during crawling. These activities could conceivably provide a continuum of position encoding during locomotion. Activity timing is related to the dynamics of each neuron’s dendritic arbors, suggesting arbor shape and targeting endow each proprioceptor with a specific role in monitoring body wall deformation. Furthermore, our results provide new insights into the body-wide activity dynamics of the proprioceptive system, which will inform models of sensory feedback during locomotion.
To investigate how dendritic arbors are built to support sensory function, I focused on proprioceptive (class I) and touch-sensing (class II-III) dendritic arborization (da) neurons. Proprioceptive and touch-sensing dendrite territories tend to target non-overlapping, neighboring, areas of the body wall. How is territory coverage specified during development, and how does this coverage support a specific sensory function? Ablation studies indicate that repulsive interactions between heterotypic dendrites are not required for territory patterning. Instead, dendrite boundaries correlate with Anterior (A)-Posterior (P) compartment boundaries in the underlying epidermal substrate: proprioceptive class I dendrites target the P compartment, while touch-sensing dendrites tend to avoid that region. I found that genetic expansion of the P compartment leads to expansion of class I proprioceptive dendrites, suggesting compartmentalized epidermal cues instruct dendrite targeting. Furthermore, SCAPE imaging revealed that the P compartment coincides with a major body wall fold that occurs during crawling. These results support a model in which dendrite targeting by compartment cues reliably tunes neurons for predictable stimuli on the body wall: proprioceptive dendrites target areas that bend predictably during crawling, while touch-sensing dendrites could be avoiding those areas to be tuned for external mechanosensory stimuli.
To investigate the molecular identity of the substrate cues guiding the compartmental organization of…
Subjects/Keywords: Neurosciences; Drosophila – Development; Dendrites; Senses and sensation; Proprioception
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vaadia, R. D. (2020). Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-9f48-0354
Chicago Manual of Style (16th Edition):
Vaadia, Rebecca Danielle. “Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.” 2020. Doctoral Dissertation, Columbia University. Accessed March 07, 2021.
https://doi.org/10.7916/d8-9f48-0354.
MLA Handbook (7th Edition):
Vaadia, Rebecca Danielle. “Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae.” 2020. Web. 07 Mar 2021.
Vancouver:
Vaadia RD. Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Mar 07].
Available from: https://doi.org/10.7916/d8-9f48-0354.
Council of Science Editors:
Vaadia RD. Development and Function of Proprioceptive Dendrite Territories in Drosophila Larvae. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-9f48-0354

Columbia University
22.
Qian, Cheng Sam.
Internal tracheal sensory neuron wiring and function in Drosophila larvae.
Degree: 2018, Columbia University
URL: https://doi.org/10.7916/D8FJ40QH
► Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms,…
(more)
▼ Organisms possess internal sensory systems to detect changes in physiological state. Despite the importance of these sensory systems for maintaining homeostasis, their development, sensory mechanisms, and circuitry are relatively poorly understood. To help address these gaps in knowledge, I used the tracheal dendrite (td) sensory neurons of Drosophila larvae as a model to gain insights into the cellular and molecular organization, developmental regulators, sensory functions and mechanisms, and downstream neural circuitry of internal sensory systems. In this thesis, I present data to show that td neurons comprise defined classes with distinct gene expression and axon projections to the CNS. The axons of one class project to the subesophageal zone (SEZ) in the brain, whereas the other terminates in the ventral nerve cord (VNC). This work identifies expression and a developmental role of the transcription factor Pdm3 in regulating the axon projections of SEZ-targeting td neurons. I find that ectopic expression of Pdm3 alone is sufficient to switch VNC-targeting td neurons to SEZ targets, and to induce the formation of putative synapses in these ectopic target regions. These results define distinct classes of td neurons and identity a molecular factor that contributes to diversification of central axon targeting. I present data to show that td neurons express chemosensory receptor genes and have chemosensory functions. Specifically, I show that td neurons express gustatory and ionotropic receptors and that overlapping subsets of td neurons are activated by decrease in O2 or increase in CO2 levels. I show that respiratory gas-sensitive td neurons are also activated when animals are submerged for a prolonged duration, demonstrating a natural-like condition in which td neurons are activated. I assessed the roles of chemosensory receptor genes in mediating the response of td neurons to O2 and CO2. As a result, I identify Gr28b as a mediator of td responses to CO2. Deletion of Gr28 genes or RNAi knockdown of Gr28b transcripts reduce the response of td neurons to CO2. Thus, these data identify two stimuli that are detected by td neurons, and establish a putative role for Gr28b in internal chemosensation in Drosophila larvae. Finally, I present data to elucidate the neural circuitry downstream of td sensory neurons. I show that td neurons synapse directly and via relays onto neurohormone populations in the central nervous system, providing neuroanatomical basis for internal sensory neuron regulation of hormonal physiology in Drosophila. These results pave the way for future work to functionally dissect the td circuitry to understand its function in physiology and behavior.
Subjects/Keywords: Neurosciences; Drosophila; Sensory neurons; Neurobiology; Dendrites; Neural circuitry
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Qian, C. S. (2018). Internal tracheal sensory neuron wiring and function in Drosophila larvae. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8FJ40QH
Chicago Manual of Style (16th Edition):
Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Doctoral Dissertation, Columbia University. Accessed March 07, 2021.
https://doi.org/10.7916/D8FJ40QH.
MLA Handbook (7th Edition):
Qian, Cheng Sam. “Internal tracheal sensory neuron wiring and function in Drosophila larvae.” 2018. Web. 07 Mar 2021.
Vancouver:
Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2021 Mar 07].
Available from: https://doi.org/10.7916/D8FJ40QH.
Council of Science Editors:
Qian CS. Internal tracheal sensory neuron wiring and function in Drosophila larvae. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8FJ40QH

University of Glasgow
23.
Naim, Magda Mohamed.
Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.
Degree: PhD, 1998, University of Glasgow
URL: http://theses.gla.ac.uk/71352/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697
► Neurokinin-1 receptor-immunoreactivity is present on many neurons in the spinal cord. A population of cells which possess the receptor is located in laminae III and…
(more)
▼ Neurokinin-1 receptor-immunoreactivity is present on many neurons in the spinal cord. A population of cells which possess the receptor is located in laminae III and IV and these cells have dorsal dendrites that penetrate the superficial laminae (I and II) of the dorsal horn. Since the dendrites of these neurons traverse several laminae, it has been suggested that they might receive input from different classes of primary afferents that terminate in these laminae. The present study investigated the input which these cells receive from two types of primary afferents: those which contain substance P (and are thought to function as nociceptors) and those with myelinated axons that terminate in laminae III-V (most of which are low-threshold mechanoreceptors). With the immunofluorescence technique and confocal microscopy, all neurons of this type were found to receive contacts from substance P-immunoreactive varicosities and in most cases the contacts onto dorsal dendrites were very numerous. The great majority of substance P-immunoreactive varicosities which formed contacts were also calcitonin gene- related peptide-immunoreactive, indicating that they were of primary afferent origin. Combined confocal and electron microscopy revealed that synapses were present at sites of contacts between substance P-immunoreactive primary afferent boutons and the dendrites of the NK-1 receptor-immunoreactive cells. Some neurons of this type belong to the spinothalamic tract and cells retrogradely-labelled after thalamic injection of cholera toxin B subunit, were therefore examined for the presence of contacts from substance P-immunoreactive axon terminals. The results indicated that the spinothalamic tract neurons which possess the NK-1 receptor and have dorsally directed dendrites also receive contacts from substance P-immunoreactive axonal varicosities onto their dorsal dendrites. By using the transganglionic transport technique, input from myelinated primary afferents which were labelled by injection of cholera toxin B subunit into the sciatic nerve were also examined. Dual-immunofluorescence and confocal microscopy revealed the presence of contacts between labelled primary afferent terminals and all of the NK-1 receptor-immunoreactive cells examined, however these contacts were much less numerous than those which the cells received from substance P-containing primary afferents. Electron microscopy revealed that synapses were present at some of the contacts between the myelinated afferents and the NK-1 receptor-immunoreactive neurons. Since cells of this type were found to receive monosynaptic input from two different classes of primary afferents, (a major input from substance P-containing afferents and a less dense input from myelinated primary afferents) it can be concluded that they are likely to have wide-dynamic-range receptive fields but with a relatively strong nociceptive component.
Subjects/Keywords: 611; Dorsal dendrites; Immunoreactivity
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Naim, M. M. (1998). Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697
Chicago Manual of Style (16th Edition):
Naim, Magda Mohamed. “Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.” 1998. Doctoral Dissertation, University of Glasgow. Accessed March 07, 2021.
http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697.
MLA Handbook (7th Edition):
Naim, Magda Mohamed. “Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor.” 1998. Web. 07 Mar 2021.
Vancouver:
Naim MM. Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. [Internet] [Doctoral dissertation]. University of Glasgow; 1998. [cited 2021 Mar 07].
Available from: http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697.
Council of Science Editors:
Naim MM. Primary afferent input to neurons in laminae III and IV of the rat spinal cord which possess the neurokinin-1 (NK-1) receptor. [Doctoral Dissertation]. University of Glasgow; 1998. Available from: http://theses.gla.ac.uk/71352/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298697

Uppsala University
24.
Morát, Julia.
Towards Stable Li-metal electrodefor rechargeable batteries.
Degree: Structural Chemistry, 2016, Uppsala University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694
► Different types of alumina containing coatings were made on lithiumand copper in the purpose to mechanically hinder the growth ofdendrites. Lithium, coated with polymer-alumina…
(more)
▼ Different types of alumina containing coatings were made on lithiumand copper in the purpose to mechanically hinder the growth ofdendrites. Lithium, coated with polymer-alumina composites wereplaced in symmetric cells for in situ studies by a light microscope.The coatings did not block the dendrites, but they did change thegrowth rate and morphology of them, probably throw both chemicalinteractions and changes in ion transportation. Also the stability ofcapacity were tested for the same coatings, the result showed abigger capacity drop for cells containing coated lithium versus cellswithout coatings.Attempted alumina coatings were also made by a solgel technique, bydirect reaction with the compound trimethylaluminium and with analumina containing acetonitrile solution.The theses also includes a study of the stability of lithium inadiponitrile. A higher amount of LiTFSI salt in adiponitrile could bythis study be reported to inhibit the dissolution of lithium that wasseen for lower salt concentrations. The dissolution appeared when thesolution was used as an electrolyte in a symmetric lithium cell. Somedifferences could be seen when the lithium surface were studied byXPS after interaction with high, low and zero concentration LiTFSI.Both the XPS studies and the absences of lithium dissolutionindicates that a more or less stable SEI had been formed.
Subjects/Keywords: Lithium metal; Battery; Dendrites; light microscopy; Adiponitrile; Al2O3; Chemical Engineering; Kemiteknik
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APA (6th Edition):
Morát, J. (2016). Towards Stable Li-metal electrodefor rechargeable batteries. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Thesis, Uppsala University. Accessed March 07, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Morát, Julia. “Towards Stable Li-metal electrodefor rechargeable batteries.” 2016. Web. 07 Mar 2021.
Vancouver:
Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Internet] [Thesis]. Uppsala University; 2016. [cited 2021 Mar 07].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Morát J. Towards Stable Li-metal electrodefor rechargeable batteries. [Thesis]. Uppsala University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-306694
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University
25.
Yalamanchili, Anurag.
Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.
Degree: Structural Chemistry, 2014, Uppsala University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378
► In this thesis, the morphological changes of the anode surface in lithium sulphur cell, during early cycling, were simulated using symmetrical lithium electrode cells…
(more)
▼ In this thesis, the morphological changes of the anode surface in lithium sulphur cell, during early cycling, were simulated using symmetrical lithium electrode cells with dissolved polysulphides (PS) in the electrolyte. Electron microscopy (SEM) was used as the principal investigation technique to study and record the morphological changes. The resulting images from the SEM were analysed and discussed. The initial surface structure of the lithium anode largely influenced the ensuing morphological changes taking place through lithium dissolution (pits) and lithium deposition (dendrites) during discharge and charge respectively. The rate of lithium dissolution and deposition was found to be linearly proportional to the current density applied to the cell and the effect of cycling on the anode was proportional to the total charge of the cell in general in agreement with the expected reaction. The effect of self-discharge on the anode was also studied using photoelectron spectroscopy (XPS) in tandem with SEM. The results indicated that self-discharge, occurring in the form of corrosion of the anode SEI by PS reduction, was influenced by the altered morphology of the cell after cycling. The findings presented in this project can be understood as a preliminary description for the morphological changes in the anode and their influence in the performance of lithium sulphur battery, which can be further investigated by more advanced methods.
Joint collaboration project between Scania CV AB and Uppsala University.
Subjects/Keywords: Lithium sulphur batteries; Li anode; morphology; dendrites; pits; cycling
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yalamanchili, A. (2014). Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Thesis, Uppsala University. Accessed March 07, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yalamanchili, Anurag. “Insights into the morphological changes undergone by the anode in the lithium sulphur battery system.” 2014. Web. 07 Mar 2021.
Vancouver:
Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Internet] [Thesis]. Uppsala University; 2014. [cited 2021 Mar 07].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yalamanchili A. Insights into the morphological changes undergone by the anode in the lithium sulphur battery system. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario
26.
Crawford, Melissa.
Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.
Degree: 2019, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/6355
► Melanocytes are specialized melanin-producing cells found in the skin, inner ear and heart. Melanocyte abnormalities cause many human disorders, including pigmentation defects, deafness, and melanoma.…
(more)
▼ Melanocytes are specialized melanin-producing cells found in the skin, inner ear and heart. Melanocyte abnormalities cause many human disorders, including pigmentation defects, deafness, and melanoma. A better understanding of melanocyte biology is essential to address those disorders. Integrin-linked kinase (ILK) is a ubiquitous scaffold protein, essential for epidermal development. Importantly, the mechanisms by which ILK modulates the development and functions of melanocytic lineage cells remains unknown. To help address this void, I have developed cell-based models, as well as a reporter mouse model that allows tamoxifen-inducible Ilk gene inactivation specifically in melanocytic cells.
I observed that inactivation of Ilk in first-wave melanoblasts significantly reduces their ability to form long pseudopods, migrate and proliferate. As a result, they do not populate the developing epidermis and hair follicles, normally. In post-natal melanocytes, ILK is required for proliferation and formation of cell extensions. Rac1 activation in response to growth factors, as well as Rac1-associated morphological changes in response to collagen-1 are defective in the absence of ILK. Exogenous expression of constitutive active Rac1 restores, to some degree, the formation of cell extensions. Thus, Rac1 functions downstream from ILK to regulate melanocyte morphology.
Melanocytes synthesize melanin in vesicles termed melanosomes. The latter travel along microtubule tracks to the tip of dendrites, where they are then transferred to neighbouring keratinocytes. I have examined the role of ILK in melanosome trafficking and melanin transfer to keratinocytes. In the absence of ILK, melanosome trafficking is abnormal, but is partially restored following stabilization of microtubules. Thus, it is likely that the alterations in melanosome movement are due to microtubule destabilization in the absence of ILK. Furthermore, I have shown that dendrite formation and melanin transfer in response to keratinocyte-secreted factors is severely reduced in the absence of ILK. Inhibition of GSK-3 partially restored dendricity, suggesting that ILK may be required to modulate GSK-3 activity and promote dendrite formation. In summary, my data suggest key roles for ILK in establishment of the melanocyte lineage, and for postnatal melanocyte functions.
Subjects/Keywords: Integrin-linked kinase; melanoblast; melanocyte; melanosomes; dendrites; melanin transfer; Cell Biology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Crawford, M. (2019). Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6355
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Crawford, Melissa. “Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.” 2019. Thesis, University of Western Ontario. Accessed March 07, 2021.
https://ir.lib.uwo.ca/etd/6355.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Crawford, Melissa. “Integrin-linked Kinase Modulation of Melanocytic Lineage Cells.” 2019. Web. 07 Mar 2021.
Vancouver:
Crawford M. Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Mar 07].
Available from: https://ir.lib.uwo.ca/etd/6355.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Crawford M. Integrin-linked Kinase Modulation of Melanocytic Lineage Cells. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6355
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario
27.
Vu, Thy H.
Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.
Degree: 2016, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/3983
► Long-term potentiation at the distal apical dendrites of CA1 pyramidal cells. This study investigated whether a theta burst stimulation (TBS) tetanus could induce long-term potentiation…
(more)
▼ Long-term potentiation at the distal apical dendrites of CA1 pyramidal cells. This study investigated whether a theta burst stimulation (TBS) tetanus could induce long-term potentiation (LTP) at the distal apical dendrites via the temporoammonic (TA) pathway and the nucleus reuniens (RE)-CA1 pathway. Neuromodulation by dopamine (DA) and acetylcholine (ACh) during LTP in the TA synapse was also investigated. Extracellular potentials were recorded in hippocampal CA1 of urethane-anaesthetized mice. LTP was induced in the TA and RE-CA1 synapses. DA and ACh were also found to have neuromodulatory roles in LTP of the TA-CA1 synapse. Mice deficient in their ability to produce vesicular ACh transporter showed a reduced ability for LTP. Co-stimulation of the ventral tegmental area (VTA) during the TA tetanus did not affect LTP; DA antagonist haloperidol injected prior to the TA tetanus also did not affect LTP. However, co-stimulation of the TA pathway and VTA after haloperidol injection reduced LTP. Therefore, LTP may be induced in vivo at the distal apical dendrites, and this plasticity at the TA synapse is modulated by DA and ACh.
Subjects/Keywords: synaptic plasticity; hippocampus; memory formation; distal apical dendrites; CA1
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vu, T. H. (2016). Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3983
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Thesis, University of Western Ontario. Accessed March 07, 2021.
https://ir.lib.uwo.ca/etd/3983.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vu, Thy H. “Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo.” 2016. Web. 07 Mar 2021.
Vancouver:
Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Mar 07].
Available from: https://ir.lib.uwo.ca/etd/3983.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vu TH. Synaptic Plasticity and Neuromodulation at the Distal Apical Dendrites Of CA1 Pyramidal Cells In Vivo. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3983
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania
28.
Francis, Chantal.
Evolution of Molecular Function in Mammalian Neurons.
Degree: 2011, University of Pennsylvania
URL: https://repository.upenn.edu/edissertations/961
► A common question in neuroscience is what forms the neurological basis of the variety of behaviors in mammals. While many studies have compared mammalian anatomy…
(more)
▼ A common question in neuroscience is what forms the neurological basis of the variety of behaviors in mammals. While many studies have compared mammalian anatomy and evolution, few have investigated the physiologic functions of individual neurons in a comparative manner. Neurons’ ability to modify their features in response to stimuli, known as synaptic plasticity, is fundamental for learning and memory. A key feature of synaptic plasticity involves delivering mRNA to distinct domains where they are locally translated. Regulatory coordination of these events is critical for synaptogenesis and synaptic plasticity as defects in these processes can lead to neurological diseases. In this work, we combine computational and experimental biology to investigate subcellular localization of mRNAs in dendrites of mouse and rat neurons. Differential subcellular localization of specific gene products may highlight differential synaptic function and allow the uncovering of evolutionary conserved as well as divergent molecular functions in neurons.
First, we performed a comparative analysis of the dendritic transcriptome in mouse and rat via microarrays. We found that their dendritic transcriptome are significantly more divergent than other homologous tissues and that these evolutionarily changes could be associated with transposon activity. Second, we comprehensively determined subcellular expression patterns for neuronal genes in mice and rats via a systematic in situ survey on a curated list of dendritic mRNA from our previous microarray study. This survey highlighted that dendritic localization of specific transcripts occurs in a species-specific fashion. We uncovered species-specific cis and trans-elements with possible implications in transcript localization and gene expression regulation in neurons. The interactions between these elements might play a major role in the proper development and evolution of complex nervous systems. Our data will be publically available in a database (http://kim.bio.upenn.edu/insitu/public/), which could guide future investigations. Finally, we investigated single cell variability by combining microarrays, RNAseq and in situ experiments. Our preliminary results underlined the extent of this variability and its contributions in establishing cell’s unique identity.
In conclusion, our study suggests the existence of species-specific mRNA localization mechanisms and supports the idea that evolution of phenotypes might be linked to the evolution of subcellular localization of transcripts.
Subjects/Keywords: mRNA; dendrites; localization; evolution; Bioinformatics; Biology; Cell Biology; Molecular Biology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Francis, C. (2011). Evolution of Molecular Function in Mammalian Neurons. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/961
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Francis, Chantal. “Evolution of Molecular Function in Mammalian Neurons.” 2011. Thesis, University of Pennsylvania. Accessed March 07, 2021.
https://repository.upenn.edu/edissertations/961.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Francis, Chantal. “Evolution of Molecular Function in Mammalian Neurons.” 2011. Web. 07 Mar 2021.
Vancouver:
Francis C. Evolution of Molecular Function in Mammalian Neurons. [Internet] [Thesis]. University of Pennsylvania; 2011. [cited 2021 Mar 07].
Available from: https://repository.upenn.edu/edissertations/961.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Francis C. Evolution of Molecular Function in Mammalian Neurons. [Thesis]. University of Pennsylvania; 2011. Available from: https://repository.upenn.edu/edissertations/961
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University
29.
Zhang, Ke.
A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.
Degree: 2020, Florida Atlantic University
URL: http://fau.digital.flvc.org/islandora/object/fau:44463
► Performance motor errors trigger animals’ adaptive learning behaviors to improve the accuracy and efficiency of the movement. The cerebellum is one of the key brain…
(more)
▼ Performance motor errors trigger animals’ adaptive learning behaviors to improve the accuracy and efficiency of the movement. The cerebellum is one of the key brain centers for encoding motor performance and motor learning. Climbing fibers relay information related to motor errors to the cerebellar cortex, evoking elevation of intracellular Ca2+ signals at Purkinje cell dendrites and inducing plasticity at coactive parallel fiber synapses, ultimately recalibrating sensorimotor associations to alter behavior. Molecular layer interneurons (MLIs) inhibit Purkinje cells to modulate dendritic excitability and action potential output. How MLIs contribute to the regulation and encoding of climbing fiber-evoked adaptive movements remains poorly understood. In this dissertation, I used genetic tools to manipulate the activity of MLIs while monitoring Purkinje cell dendritic activity during a cerebellum-dependent motor learning task with different contexts to evaluate how MLIs are involved in this process. The results show that by suppressing dendritic Ca2+ signals in Purkinje cells, MLI activity coincident with climbing fiber-mediated excitation prevents the occurrence of learning when adaptation is not necessary. On the other hand, with error signals present, disinhibition onto Purkinje cells, mediated by MLI-MLI microcircuit, unlocked the ability of climbing fibers to induce plasticity and motor learning.
2020
Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2020.
Collection: FAU
Advisors/Committee Members: Christie, Jason (Thesis advisor), Dawson-Scully, Ken (Thesis advisor), Florida Atlantic University (Degree grantor), Department of Biological Sciences, Charles E. Schmidt College of Science.
Subjects/Keywords: Cerebellum; Interneurons; Purkinje cells; Dendrites; Sensorimotor integration; Neuroplasticity
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhang, K. (2020). A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:44463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Ke. “A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.” 2020. Thesis, Florida Atlantic University. Accessed March 07, 2021.
http://fau.digital.flvc.org/islandora/object/fau:44463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Ke. “A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING.” 2020. Web. 07 Mar 2021.
Vancouver:
Zhang K. A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. [Internet] [Thesis]. Florida Atlantic University; 2020. [cited 2021 Mar 07].
Available from: http://fau.digital.flvc.org/islandora/object/fau:44463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang K. A DISINHIBITORY MICROCIRCUIT FOR GATED CEREBELLAR LEARNING. [Thesis]. Florida Atlantic University; 2020. Available from: http://fau.digital.flvc.org/islandora/object/fau:44463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto
30.
Sekulic, Vladislav.
Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.
Degree: PhD, 2018, University of Toronto
URL: http://hdl.handle.net/1807/89679
► The hippocampus is a brain structure implicated in memory formation and spatial navigation. Understanding the structure and function of the hippocampal system is important in…
(more)
▼ The hippocampus is a brain structure implicated in memory formation and spatial navigation. Understanding the structure and function of the hippocampal system is important in developing an understanding of its functioning in behaviour and neurological disease. Inhibitory interneurons in the hippocampus serve a primary role in the generation of hippocampal network rhythms which have been linked to behaviour. One type of interneuron in the hippocampal CA1 region is the oriens-lacunosum/moleculare (O-LM) cell, which forms inhibitory synapses onto local pyramidal cells. O-LM cells express hyperpolarization-activated mixed cation currents (Ih) that contribute to cellular excitability and action potential generation. Although experimental investigations have implicated Ih in the activity of O-LM cells in hippocampal activity, it is currently unknown how Ih interacts with other voltage-gated channels and synaptic inputs to shape O-LM cell output. In this thesis, I develop and use computational models of O-LM cells that are constrained by experimental recordings to study how expression and distribution of Ih allows O-LM cells to be recruited in hippocampal networks. I first find that varying dendritic distributions of Ih in O-LM cell models can equally capture electrophysiological output of O-LM cells, so long as the total membrane current due to Ih is conserved. I then show that somatic or dendritic distributions of Ih can tune O-LM cell models to participate in different network rhythms expressed in hippocampus that have been implicated in either mnemonic or emotional behaviour. Finally, I develop a new set of multi-compartment models of O-LM cells using recently acquired experimental data. These models lead to a prediction of dendritic Ih expression in the set of O-LM cells from which the recordings were obtained. My work thus represents a link in the chain of elucidating how cellular electrophysiological properties of inhibitory interneurons allow them to perform their roles in hippocampal activity.
Advisors/Committee Members: Skinner, Frances K., Physiology.
Subjects/Keywords: Computational Modelling; Dendrites; HCN; Hippocampus; Interneurons; Theoretical Neuroscience; 0317
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sekulic, V. (2018). Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89679
Chicago Manual of Style (16th Edition):
Sekulic, Vladislav. “Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.” 2018. Doctoral Dissertation, University of Toronto. Accessed March 07, 2021.
http://hdl.handle.net/1807/89679.
MLA Handbook (7th Edition):
Sekulic, Vladislav. “Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling.” 2018. Web. 07 Mar 2021.
Vancouver:
Sekulic V. Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1807/89679.
Council of Science Editors:
Sekulic V. Investigating the Contribution of Hyperpolarization-Activated Mixed Cation Channels to the Role of Oriens-Lacunosum/Moleculare Interneurons in Oscillatory Activity of the Hippocampus Using Computational Modelling. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89679
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