subject:(Demyelinating Diseases)

University of Texas Southwestern Medical Center

1. Tan, Alexander. Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis.

Degree: 2018, University of Texas Southwestern Medical Center

► Research shows that youth with multiple sclerosis (MS) are at risk for neuropsychological deficits due to cerebral involvement, but establishing a clear profile remains difficult… (more)

▼ Research shows that youth with multiple sclerosis (MS) are at risk for neuropsychological deficits due to cerebral involvement, but establishing a clear profile remains difficult due to disease complexity. Emerging evidence also shows neuropsychological deficits and the possibility of brain-based involvement in youth with transverse myelitis (TM) despite absence of obvious cerebral pathology. The present objective is to further investigate neuropsychological sequelae associated with pediatric MS and TM by characterizing and comparing neurocognitive and psychosocial profiles using profile analysis, a method which has not been utilized to investigate neuropsychological functioning in pediatric demyelinating diseases. Sixty-two pediatric MS and 46 pediatric idiopathic TM participants were administered brief neuropsychological screening evaluations during routine clinical care. Separate profile analyses were conducted on performance-based neurocognitive and parent-rated psychosocial variables of interest. Results of the neurocognitive profile analysis revealed significantly (p < .05) poorer overall performance in MS, with measures of cognitive flexibility, visual-motor integration, and fine-motor speed and dexterity found to be significant (p < .05) contributors to combined profiles. However, no significant difference was found in profile patterns between MS and TM groups. Results of the psychosocial profile analysis revealed no significant difference in overall levels of psychosocial problems between groups, with no individual measures found to be significant contributors to combined profiles. However, a significant (p < .05) difference in profile patterns was found between MS and TM groups, characterized by increased elevations in working memory and attention difficulties in MS and physical and social quality of life difficulties in TM. These findings elucidate the neurocognitive and psychosocial sequelae of pediatric MS and TM. While it is established that pediatric patients with MS often present with wide-ranging neuropsychological deficits consistent with brain-based pathology, the present study shows that pediatric patients with TM are also considered to be at risk for neuropsychological difficulties, suggesting that disease mechanisms may impact brain function despite the lack of obvious cerebral involvement. Findings of the current study indicate neuropsychologists play an important role in assessment and treatment planning for these populations, and youth with TM may also benefit from interventions to address cognitive and psychosocial problems. Advisors/Committee Members: Harder, Lana, Hughes, Jennifer L., Hynan, Linda S., Lacritz, Laura H., Greenberg, Benjamin M..

Subjects/Keywords: Demyelinating Diseases; Multiple Sclerosis; Neuropsychiatry

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APA (6^th Edition):

Tan, A. (2018). Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/8807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tan, Alexander. “Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis.” 2018. Thesis, University of Texas Southwestern Medical Center. Accessed February 28, 2021. http://hdl.handle.net/2152.5/8807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tan, Alexander. “Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis.” 2018. Web. 28 Feb 2021.

Vancouver:

Tan A. Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2152.5/8807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tan A. Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis. [Thesis]. University of Texas Southwestern Medical Center; 2018. Available from: http://hdl.handle.net/2152.5/8807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Carlos Augusto Ciarlini Teixeira. CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010.

Degree: PhD, 2011, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7515 ;

►

Para analisar a histÃria natural da Esclerose MÃltipla (EM) no estado do CearÃ, Brasil, o autor estuda retrospectivamente 146 pacientes diagnosticados por critÃrios de Poser… (more)

▼

Para analisar a histÃria natural da Esclerose MÃltipla (EM) no estado do CearÃ, Brasil, o autor estuda retrospectivamente 146 pacientes diagnosticados por critÃrios de Poser e / ou McDonald-2010. CasuÃstica e mÃtodos: dados biogrÃficos, clÃnicos e para-clÃnicos obtidos em visitas ambulatoriais e nos surtos. Considera como desfechos de incapacidade os marcos EDSS 4, 6 e 7. Com software estatÃstico R ( RKWard 0.5.3 ) faz anÃlise descritiva, teste exato de Fisher (p < 0,05) e curvas de anÃlise de tempo atÃ o evento ( Kaplan-Meier). Mais de 75 % dos pacientes sÃo acompanhados durante atÃ 15 anos. Resultados: EM predomina no sexo feminino (80,82 %); tem inÃcio antes dos 30 anos de idade em 47,9 % dos casos. Pacientes com educaÃÃo de nÃvel superior (33,5 %) representam mais do dobro do esperado na populaÃÃo em geral. Nas avaliaÃÃes inicial e evolutiva predominam os sintomas sensitivos, motores e esfincterianos. Pacientes mais jovens e com evoluÃÃo recorrente â remitente atingem EDSS 4 apÃs maior intervalo de tempo. A proporÃÃo de casos de EM benigna Ã de 4,7 %. A taxa anualizada de surtos Ã 0,6. Os dois primeiros surtos da maioria dos pacientes ocorreram nos primeiros 3 anos. O tempo entre 1Â e 2Â surtos tem relaÃÃo positiva com o tempo para atingir EDSS 4, 6 e 7. A duraÃÃo da doenÃa atÃ o Ãbito (8 casos, 5,4 %) foi em mÃdia de 14,4 anos. PrevalÃncia de EM no estado do CearÃ Ã estimada em 2,9 / 100.000 habitantes. ConclusÃo: As caracterÃsticas clÃnicas e evolutivas da EM, no estado do CearÃ (latitude sul entre 2o 46â e 7o 52â), sÃo semelhantes Ãs observadas mundialmente.

In order to study the natural history of Multiple Sclerosis (MS) in the state of CearÃ, Brazil, the author retrospectively analyzes 146 patients diagnosed according to Poser and/or McDonald-2010 criteria. Cases and methods: biographical, clinical and para-clinical data collected on outpatient visits and at relapses. EDSS scores 4, 6 and 7 used as disability outcomes. Statistical software R (RKWard 0.5.3) used to perform descriptive analysis, Fisher exact test (p< 0,05) and time-to-the-event curves (Kaplan-Meier). Results: over 75 % of the patients followed for as long as 15 years; disease onset before 30 years of age in 47,9 %, with female sex preponderance (80.82 %). Patients with university education (33,5 %) are in high proportion when compared to the general population. Sensory, motor and sphincter complaints are the most common, in both initial and final examinations. Younger patients with relapsing-remitting MS took a longer time to reach EDSS 4. The proportion of benign MS cases was 4, 7 %. Annualized relapse rate was 0,6 . For most patients, the first two relapses took place in the initial three years of illness.Time between 1st. and 2nd relapses bears a positive relationship with time to reach EDSS 4, 6 and 7. Disease duration until death (8 cases , 5,4 %) was an average of 14,4 years. The prevalence of MS in the state of CearÃ, Brazil, is estimated as 2,9 / 100.000 inhabitants. Conclusion: Clinical course of MS in the…

Advisors/Committee Members: Manoel Odorico de Moraes Filho, Otoni Cardoso do Vale, Francisco Marcos Bezerra da Cunha, JosÃ Arnaldo Motta de Arruda, Norberto Anizio Ferreira Frota.

Subjects/Keywords: FARMACOLOGIA; Esclerose MÃltipla; PrevalÃncia; DoenÃas Desmielinizantes; Multiple Sclerosis; Prevalence; Demyelinating Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Teixeira, C. A. C. (2011). CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010. (Doctoral Dissertation). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7515 ;

Chicago Manual of Style (16^th Edition):

Teixeira, Carlos Augusto Ciarlini. “CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010.” 2011. Doctoral Dissertation, Universidade Federal do Ceará. Accessed February 28, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7515 ;.

MLA Handbook (7^th Edition):

Teixeira, Carlos Augusto Ciarlini. “CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010.” 2011. Web. 28 Feb 2021.

Vancouver:

Teixeira CAC. CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010. [Internet] [Doctoral dissertation]. Universidade Federal do Ceará 2011. [cited 2021 Feb 28]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7515 ;.

Council of Science Editors:

Teixeira CAC. CaracterÃsticas clÃnicas e epidemiolÃgicas de 146 pacientes com esclerose mÃltipla acompanhados na cidade de Fortaleza, CE, Brasil, entre os anos 1979 e 2010. [Doctoral Dissertation]. Universidade Federal do Ceará 2011. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7515 ;

3. Preston, Marnie Anne. Novel mechanisms underlying hyaluronan-mediated remyelination failure.

Degree: PhD, 2011, Oregon Health Sciences University

URL: doi:10.6083/M4HM56FW ; http://digitalcommons.ohsu.edu/etd/677

Subjects/Keywords: Oligodendroglia; Demyelination; Hyaluronan; Oligodendroglia; Demyelinating Diseases; Hyaluronic Acid; Hyaluronoglucosaminidase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Preston, M. A. (2011). Novel mechanisms underlying hyaluronan-mediated remyelination failure. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4HM56FW ; http://digitalcommons.ohsu.edu/etd/677

Chicago Manual of Style (16^th Edition):

Preston, Marnie Anne. “Novel mechanisms underlying hyaluronan-mediated remyelination failure.” 2011. Doctoral Dissertation, Oregon Health Sciences University. Accessed February 28, 2021. doi:10.6083/M4HM56FW ; http://digitalcommons.ohsu.edu/etd/677.

MLA Handbook (7^th Edition):

Preston, Marnie Anne. “Novel mechanisms underlying hyaluronan-mediated remyelination failure.” 2011. Web. 28 Feb 2021.

Vancouver:

Preston MA. Novel mechanisms underlying hyaluronan-mediated remyelination failure. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2011. [cited 2021 Feb 28]. Available from: doi:10.6083/M4HM56FW ; http://digitalcommons.ohsu.edu/etd/677.

Council of Science Editors:

Preston MA. Novel mechanisms underlying hyaluronan-mediated remyelination failure. [Doctoral Dissertation]. Oregon Health Sciences University; 2011. Available from: doi:10.6083/M4HM56FW ; http://digitalcommons.ohsu.edu/etd/677

4. Ketelslegers, Immy. Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis.

Degree: 2014, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/50369

► markdownabstract__Abstract__ Acquired inflammatory demyelinating diseases of the central nervous system (CNS) cause damage to myelin sheaths and typically result in white matter lesions due to… (more)

Subjects/Keywords: Multiple Sclerosus; MS; central nervous system; inflammatory demyelinating diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ketelslegers, I. (2014). Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/50369

Chicago Manual of Style (16^th Edition):

Ketelslegers, Immy. “Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis.” 2014. Doctoral Dissertation, Erasmus University Medical Center. Accessed February 28, 2021. http://hdl.handle.net/1765/50369.

MLA Handbook (7^th Edition):

Ketelslegers, Immy. “Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis.” 2014. Web. 28 Feb 2021.

Vancouver:

Ketelslegers I. Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1765/50369.

Council of Science Editors:

Ketelslegers I. Acquired Demyelinating Syndromes and Pediatric Multiple Sclerosis. [Doctoral Dissertation]. Erasmus University Medical Center; 2014. Available from: http://hdl.handle.net/1765/50369

5. Thomas, Ruth Erin. Studies on the function and mechanism of action of attractin.

Degree: PhD, 2005, Oregon Health Sciences University

URL: doi:10.6083/M41V5C7B ; http://digitalcommons.ohsu.edu/etd/2964

Subjects/Keywords: Drosophila Proteins; Ubiquitin-Conjugating Enzymes; Nerve Degeneration; Pigmentation Disorders; Demyelinating Diseases; Immunity, Innate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thomas, R. E. (2005). Studies on the function and mechanism of action of attractin. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M41V5C7B ; http://digitalcommons.ohsu.edu/etd/2964

Chicago Manual of Style (16^th Edition):

Thomas, Ruth Erin. “Studies on the function and mechanism of action of attractin.” 2005. Doctoral Dissertation, Oregon Health Sciences University. Accessed February 28, 2021. doi:10.6083/M41V5C7B ; http://digitalcommons.ohsu.edu/etd/2964.

MLA Handbook (7^th Edition):

Thomas, Ruth Erin. “Studies on the function and mechanism of action of attractin.” 2005. Web. 28 Feb 2021.

Vancouver:

Thomas RE. Studies on the function and mechanism of action of attractin. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2005. [cited 2021 Feb 28]. Available from: doi:10.6083/M41V5C7B ; http://digitalcommons.ohsu.edu/etd/2964.

Council of Science Editors:

Thomas RE. Studies on the function and mechanism of action of attractin. [Doctoral Dissertation]. Oregon Health Sciences University; 2005. Available from: doi:10.6083/M41V5C7B ; http://digitalcommons.ohsu.edu/etd/2964

6. Carvalho, Fabricio Leite de. Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida.

Degree: PhD, Urologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-27082014-084739/ ;

► INTRODUÇÃO: Neuromielite óptica (NMO) e suas formas limitadas são doenças desmielinizantes autoimunes do sistema nervoso central que acometem preferencialmente a medula espinhal e o nervo… (more)

▼ INTRODUÇÃO: Neuromielite óptica (NMO) e suas formas limitadas são doenças desmielinizantes autoimunes do sistema nervoso central que acometem preferencialmente a medula espinhal e o nervo óptico. Várias formas clínicas do espectro da NMO (NMO-SD) tem sido descritas e incluem desde um evento único de mielite transversa longitudinalmente extensa (MTLE) à NMO recorrente. O comprometimento neurológico destes pacientes pode levar a diversas disfunções autonômicas, incluindo disfunção miccional. OBJETIVOS: Determinar a prevalência e as características dos sintomas do trato urinário inferior (STUI) e dos achados urodinâmicos em pacientes portadores de NMO-SD, e analisar suas associações com o grau de comprometimento neurológico e qualidade de vida (QV). MÉTODOS: Avaliamos 30 pacientes (23 mulheres e 7 homens) com diagnóstico estabelecido de NMO-SD, que foram convidados a participar do estudo a despeito de apresentarem ou não STUI. A avaliação neurológica foi realizada por meio da Escala Expandida do Estado de Incapacidade (EDSS), ressonância magnética de crânio e coluna vertebral, e dosagem de NMOIgG. Os STUI foram avaliados pelo Questionário de Avaliação da Bexiga Hiperativa (OAB-V8) e pelo Escore Internacional de Sintomas Prostáticos (IPSS). A qualidade de vida de forma geral foi avaliada pelo questionário de Satisfação com a Vida (LiSat-9). Todos os pacientes foram submetidos ao estudo videourodinâmico. RESULTADOS: A idade média dos pacientes foi de 41,1 ± 13,5 anos (intervalo de 13 a 70) e o tempo médio de duração da doença neurológica foi de 33,8 ± 30,8 meses (intervalo de 3 a 135). A avaliação neurológica mostrou pacientes com EDSS médio de 5,3 ± 1,8 (intervalo de 1 a 8,5). O escore médio do OAB-V8 foi de 17,5 ± 14,0 (intervalo de 0 a 40) e de 14,3 ± 10,6 (intervalo de 0 a 35) para o I-PSS. A média da QV geral medida pelo Lisat-9 foi de 38,9 ± 6,8 (intervalo de 26 a 49). Os STUI mais comuns foram urgência em 15 (50%) pacientes, noctúria em 15 (50%), jato urinário fraco em 15 (50%), intermitência em 14 (46,6%), esvaziamento incompleto em 13 (43,3%), hesitação em 13 (43,3%), aumento da frequência urinária em 13 (43,3%) e urge-incontinência em 5 (16%). Os achados urodinâmicos mais comuns foram hiperatividade detrusora (HD) com dissinergia detrusor-esfincteriana (DDE) em 11 (36,6%) pacientes, DDE sem HD em 7 (23,3%), HD sem DDE em 6 (20%), e incontinência urinária de esforço em 1 (3,3%). Cinco (16,6%) pacientes apresentaram estudo videourodinâmico sem anormalidades. Sintomas urinários medidos pelo IPSS e pelo OAB-V8 correlacionaram-se com maior comprometimento neurológico (r=0,42; p=0,018 e r=0,48; p=0,006 respectivamente). Pacientes portadores de DDE foram aqueles que mostraram maior comprometimento neurológico (p=0,027). Da mesma forma, pacientes dissinérgicos apresentaram maiores escores ao I-PSS (p=0,029) e ao OAB-V8 (p=0,008). Pacientes com maior comprometimento neurológico foram aqueles que apresentaram pior QV (r=-0,410; p=0,022). CONCLUSÃO: Encontramos alta prevalência de STUI e disfunção miccional em portadores… Advisors/Committee Members: Gomes, Cristiano Mendes.

Subjects/Keywords: Demyelinating diseases; Doenças desmielinizantes; Lower urinary tract symptoms; Neuromielite óptica; Neuromyelitis optica; Qualidade de vida; Quality of life; Sintomas do trato urinário inferior; Urodinâmica; Urodynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carvalho, F. L. d. (2014). Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5153/tde-27082014-084739/ ;

Chicago Manual of Style (16^th Edition):

Carvalho, Fabricio Leite de. “Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida.” 2014. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-27082014-084739/ ;.

MLA Handbook (7^th Edition):

Carvalho, Fabricio Leite de. “Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida.” 2014. Web. 28 Feb 2021.

Vancouver:

Carvalho FLd. Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-27082014-084739/ ;.

Council of Science Editors:

Carvalho FLd. Caracterização das disfunções miccionais em pacientes portadores do espectro da neuromielite óptica e suas associações com o comprometimento neurológico e a qualidade de vida. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/5/5153/tde-27082014-084739/ ;

7. 山本, 梓司. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.

Degree: 博士(医学), 2018, Saitama Medical University / 埼玉医科大学

URL: http://id.nii.ac.jp/1386/00000615/

►

Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination,… (more)

▼

Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn-2 and sn-3 positions of the glycerol backbone. We reported earlier that cPA elicits a neurotrophin-like action and protects hippocampal neurons from ischemia-induced delayed neuronal death. We designed, chemically synthesized, and metabolically stabilized derivatives of cPA: 2-carba-cPA (2ccPA), a synthesized compound in which one of the phosphate oxygen molecules is replaced with a methylene group at the sn-2 position. In the present study, we investigated whether 2ccPA exerts protective effects in oligodendrocytes and suppresses pathology in the two most common mouse models of multiple sclerosis.

To evaluate whether 2ccPA has potential beneficial effects on the pathology of multiple sclerosis, we investigated the effects of 2ccPA on oligodendrocyte cell death in vitro and administrated 2ccPA to mouse models of experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination.

We demonstrated that 2ccPA suppressed the CoCl

-induced increase in the Bax/Bcl-2 protein expression ratio and phosphorylation levels of p38MAPK and JNK protein. 2ccPA treatment reduced cuprizone-induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction. Furthermore, 2ccPA treatment reduced autoreactive T cells and macrophages, spinal cord injury, and pathological scores in EAE, the autoimmune multiple sclerosis mouse model.

We demonstrated that 2ccPA protected oligodendrocytes via suppression of the mitochondrial apoptosis pathway. Also, we found beneficial effects of 2ccPA in the multiperiod of cuprizone-induced demyelination and the pathology of EAE. These data indicate that 2ccPA may be a promising compound for the development of new drugs to treat demyelinating disease and ameliorate the symptoms of multiple sclerosis.

平成29年度

Subjects/Keywords: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Differentiation; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Humans; MAP Kinase Signaling System; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidic Acids; Proto-Oncogene Proteins c-bcl-2; p38 Mitogen-Activated Protein Kinases

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APA (6^th Edition):

山本, �. (2018). Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. (Thesis). Saitama Medical University / 埼玉医科大学. Retrieved from http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Thesis, Saitama Medical University / 埼玉医科大学. Accessed February 28, 2021. http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Web. 28 Feb 2021.

Vancouver:

山本 �. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Internet] [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. [cited 2021 Feb 28]. Available from: http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

山本 �. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. Available from: http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

8. Πολυζωΐδου, Ελένη. Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα.

Degree: 2007, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/19538

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Neural stem cell transplantation has been proposed as a mean of cell replacement therapy for various diseases of the central nervous system (CNS). Transplanted neural… (more)

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Neural stem cell transplantation has been proposed as a mean of cell replacement therapy for various diseases of the central nervous system (CNS). Transplanted neural precursors of various origins improved the clinical outcome in experimental models of stroke and spinal cord trauma. Although transplanted myelin-forming cells have remarkable remyelinating properties the exact mechanisms by which they react are not clear yet. In multiple sclerosis (MS), as well as in experimental allergic encephalomyelitis (EAE), a model of MS, demyelination and inflammation-related axonal pathology lead to chronic neurological disability. Here, we transplanted neural stem cells (NSCs) into the ventricles of mice at day 7 after induction of chronic EAE. Transplanted cells attenuated the clinical course of disease and migrated into the white matter. NPC transplantation down-regulated the inflammatory brain process at the acute phase of disease, as indicated by a reduction in the number of perivascular infiltrates. Demyelination and acute axonal injury in this model are considered to result mainly from the acute inflammatory process and correlate well with the chronic neurological residua. Except for the downregulation of the inflammatory process, the transplanted cells reduced the primary demyelination and axonal injury and induced the remyelination of demyelinated axons, a result though which did not derive directly from the transplanted cells. In consequence to inhibition of brain inflammation, precursor cell transplantation attenuated the primary demyelinating process and reduced the acute axonal injury. As a result, the size of demyelinated areas and extent of chronic axonal pathology were reduced in the transplanted brains. We suggest that the beneficial effect of transplanted NPCs in chronic EAE is mediated, in part, by decreasing brain inflammation and reducing tissue injury and finally to improvement in the clinical outcome.

Η μεταμόσχευση των στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος (ΚΝΣ), έχει προταθεί ως μέσο για τη θεραπεία ποικίλων νοσημάτων του ΚΝΣ. Τα μεταμοσχευμένα στελεχιαία προγονικά κύτταρα βελτίωσαν την κλινική πορεία των πειραματόζωων σε διαφορετικά πειραματικά μοντέλα όπως της εγκεφαλικής ισχαιμίας και της κάκωσης του νωτιαίου μυελού. Παρ’ όλο που τα μεταμοσχευμένα κύτταρα εμφανίζουν σημαντικές επαναμυελινωτικές ιδιότητες, δεν είναι ακόμα γνωστοί οι ακριβείς μηχανισμοί με τους οποίους δρουν. Στην πολλαπλή σκλήρυνση, όπως και στο πειραματικό μοντέλο της νόσου, την πειραματική αλλεργική εγκεφαλομυελίτιδα (ΠΑΕ), η απομυελίνωση και η παθολογία των νευραξόνων η οποία σχετίζεται με τη φλεγμονή, έχουν ως αποτέλεσμα το χρόνιο νερολογικό έλλειμμα. Στην παρούσα μελέτη μεταμοσχεύθηκαν στελεχιαία προγονικά κύτταρα του ΚΝΣ στις πλάγιες κοιλίες μυών την 7η ημέρα μετά την επαγωγή της χρόνιας ΠΑΕ. Τα μεταμοσχευμένα κύτταρα βελτίωσαν την κλινική πορεία των πειραματόζωων και μετανάστευσαν στη λευκή ουσία των εγκεφάλων τους. Η μεταμόσχευση των κυττάρων κατέστειλε τη φλεγμονώδη διαδικασία στον εγκέφαλο,…

Subjects/Keywords: Κεντρικό νευρικό σύστημα; Κύτταρα, Στελεχιαία; Πολλαπλή σκλήρυνση; Εγκεφαλομυελίτιδα, Πειραματική αλλεργική; Μεταμοσχεύσεις; Μυελίνη; Νοσήματα, Απομυελινωτικά; Central nervous system; Stem cells; Multiple sclerosis; Encephalomyelitis, Experimental allergic; Transplantation; Myelin; Diseases, Demyelinating

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APA (6^th Edition):

Πολυζωΐδου, . �. (2007). Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/19538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Πολυζωΐδου, Ελένη. “Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα.” 2007. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed February 28, 2021. http://hdl.handle.net/10442/hedi/19538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Πολυζωΐδου, Ελένη. “Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα.” 2007. Web. 28 Feb 2021.

Vancouver:

Πολυζωΐδου �. Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10442/hedi/19538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Πολυζωΐδου �. Μεταμόσχευση στελεχιαίων προγονικών κυττάρων του κεντρικού νευρικού συστήματος στη πειραματική αλλεργική εγκεφαλομυελίτιδα. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2007. Available from: http://hdl.handle.net/10442/hedi/19538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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