Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:(Degradable hydrogels). Showing records 1 – 2 of 2 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Georgia Tech

1. Lloyd, Jessica. Development of biocompatible dextran-oxanorbornadiene hydrogels.

Degree: MS, Chemistry and Biochemistry, 2019, Georgia Tech

Hydrogels have garnered much attention over the past few decades for their ability to deliver therapeutics with spatial and temporal control. However, many of these systems can exhibit burst release and are not easily adjusted to realize different release kinetics. The research reported in this thesis aims to develop tunable degradable hydrogels from oxanorbornadiene linkers, which have been shown to have programmable fragmentation rates that can be tuned over an exceptionally wide range of time. OND hydrogels of different crosslinking compositions were all able to form robust gels in as little as seconds and release of entrained cargo was found to be tunable over 0.5 to 25 days by changing the OND substitution or crosslinking system. Oxanorbornadiene hydrogels were then applied to in vivo models seeking to improve healing in chronic wounds where it was found that OND hydrogels were able to deliver therapeutic cargo at the expected preprogrammed rates to improve wound healing. Degradable hydrogels comprised of OND cleavable linkages continue to show great promise as simple drug delivery systems that can be widely useful to applications requiring controlled release over hours or months. Advisors/Committee Members: Finn, M. G. (advisor), Gutekunst, Will (committee member), Reddi, Amit (committee member).

Subjects/Keywords: Degradable hydrogels; Drug delivery

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lloyd, J. (2019). Development of biocompatible dextran-oxanorbornadiene hydrogels. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/61784

Chicago Manual of Style (16th Edition):

Lloyd, Jessica. “Development of biocompatible dextran-oxanorbornadiene hydrogels.” 2019. Masters Thesis, Georgia Tech. Accessed October 15, 2019. http://hdl.handle.net/1853/61784.

MLA Handbook (7th Edition):

Lloyd, Jessica. “Development of biocompatible dextran-oxanorbornadiene hydrogels.” 2019. Web. 15 Oct 2019.

Vancouver:

Lloyd J. Development of biocompatible dextran-oxanorbornadiene hydrogels. [Internet] [Masters thesis]. Georgia Tech; 2019. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1853/61784.

Council of Science Editors:

Lloyd J. Development of biocompatible dextran-oxanorbornadiene hydrogels. [Masters Thesis]. Georgia Tech; 2019. Available from: http://hdl.handle.net/1853/61784


University of New Mexico

2. Rush, Matthew N. CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING.

Degree: Nanoscience and Microsystems, 2018, University of New Mexico

As a cell mediated-process, valvular heart disease (VHD) results in significant morbidity and mortality world-wide. In the US alone, valvular heart disease VHD is estimated to affect 2.5% of the population with a disproportionate impact on an increasing elderly populous. It is well understood that the primary driver for valvular calcification is the differentiation of valvular interstitial cells (VICs) into an osteoblastic-like phenotype. However, the factors leading to the onset of osteoblastic-like VICs (obVICs) and resulting calcification are not fully understood and a more complete characterization of VIC differentiation and phenotypic change is required before treatment of valve disease or growth of tissue engineered heart valves (TEHVs) can be realized. By investigating the microenvironmental cues at the cell-material interface, surface chemistry, protein adhesion, and integrin expression we have identified cell-material signaling that may be responsible for heart valve tissue calcification as well as healthy in vitro growth environments. These studies were then translated into a three-dimensional hydrogel system for the study of VICs in a more physically relevant cell culture system. Advisors/Committee Members: Elizabeth L. Hedberg-Dirk, Andrew P. Shreve, Linnea K. Ista, Gabriel A. MontaƱo.

Subjects/Keywords: Valvular Interstitial Cells; Heart Valve; Tissue Engineering; Degradable Hydrogels; Self-Assembled Monolayers; Biomaterials; Cell Biology; Molecular, Cellular, and Tissue Engineering; Nanoscience and Nanotechnology

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rush, M. N. (2018). CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/nsms_etds/47

Chicago Manual of Style (16th Edition):

Rush, Matthew N. “CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING.” 2018. Doctoral Dissertation, University of New Mexico. Accessed October 15, 2019. https://digitalrepository.unm.edu/nsms_etds/47.

MLA Handbook (7th Edition):

Rush, Matthew N. “CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING.” 2018. Web. 15 Oct 2019.

Vancouver:

Rush MN. CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING. [Internet] [Doctoral dissertation]. University of New Mexico; 2018. [cited 2019 Oct 15]. Available from: https://digitalrepository.unm.edu/nsms_etds/47.

Council of Science Editors:

Rush MN. CHEMICALLY MODIFIED MONOLAYER SURFACES INFLUENCE VALVULAR INTERSTITIAL CELL ATTACHMENT AND DIFFERENTIATION FOR HEART VALVE TISSUE ENGINEERING. [Doctoral Dissertation]. University of New Mexico; 2018. Available from: https://digitalrepository.unm.edu/nsms_etds/47

.