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You searched for subject:(D tagatose). Showing records 1 – 3 of 3 total matches.

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1. Simão, Ana Catarina. Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses.

Degree: Docteur es, Chimie organique, 2009, Orléans; Université de Lisbonne

Une réaction simple de condensation de l'acide thiocyanique avec un cétohexose peut conduire à la formation d’une dizaine de 10 oxazolidinethiones (OZTs) ou oxazolinethiones (OXTs) distinctes. La question que nous nous sommes posée a été “comment gérer une chimie aussi complexe?” Un contrôle attentif des conditions de réaction, associé à des séquences de purification comportant des protections sélectives et diverses fonctionnalisations, peuvent certainement être utiles. Un jeu chimique subtil et stimulant a été développé entre des pré- et post-protections sélectives et des réactions originales de fonctionnalisation. Dans ce travail de thèse, nous avons mis à l’étude de nouvelles tactiques de synthèse et de purification pour accéder à des OZTs et des oxazolidinones (OZOs) ancrées sur des charpentes des cétohexoses. Ces travaux ont été mis en application notamment en série D-fructo et dans les séries épimères D-psico et D-tagato dont la chimie ont été peu explorée en comparaison d’autres séries monosaccharidiques. Nous avons ainsi mieux maîtrisé les approches chimiques permettant d’accéder à ces thionocarbamates saccharidiques et ainsi de valoriser ces molécules dont l’intérêt d’un point de vue biologique et chimique est important. Dans ces études, nous avons élaboré une bibliothèque de formes tautomères fixes de composés hybrides qui ont été soumis à des essais biologiques. Ainsi, ce groupe de composés a fait l’objet de tests antimicrobiens, livrant des résultats très intéressants. Par ailleurs, les meilleurs inhibiteurs de GLUT5 seront utilisés dans le développement de nouveaux outils biochimiques pour une meilleure compréhension des rôles joués par ce transporteur du D-fructose en relation au le diabète de type 2 et de l'obésité.

A simple condensation reaction of thiocyanic acid with a ketohexose can provide a library of up to 10 different molecules composed of oxazolidinethiones (OZTs) or oxazolinethiones (OXTs). The question arising is “how to manage such a complex chemistry?” Careful control of the reaction conditions associated with purification sequences (involving selective protection or functionalization) can certainly help. A subtle and challenging chemical game could be played between selective pre- and post-protections and original functionalizing reactions. In this PhD work, we disclose the development of new chemical and purification tactics to access OZTs and oxazolidinones (OZOs) anchored onto ketohexose scaffolds, namely D-fructo and its epimers D-psico, D-tagato, whose chemistry has been poorly investigated in comparison with other monosaccharidic systems. Furthermore we have improved our understanding about saccharidic thionocarbamates chemistry for a better valorization from both chemical and biological point of view. We have generated a library of fixed tautomeric forms of hybrid compounds to be submitted to biological tests. This panel of compounds was subjected to antimicrobial screening and some molecules have shown very efficient effects. Moreover, the leading inhibitors of GLUT5 will be…

Advisors/Committee Members: Rauter, Amélia Pilar (thesis director), Rollin, Patrick (thesis director).

Subjects/Keywords: Oxazolidinethiones; Oxazolidinones; Cétohexoses; D-fructose; D-psicose; D-tagatose; Thionocarbamates; Oxazolidinethiones; Oxazolidinones; Ketohexoses; D-fructose; D-psicose; D-tagatose; Thionocarbamates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Simão, A. C. (2009). Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses. (Doctoral Dissertation). Orléans; Université de Lisbonne. Retrieved from http://www.theses.fr/2009ORLE2038

Chicago Manual of Style (16th Edition):

Simão, Ana Catarina. “Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses.” 2009. Doctoral Dissertation, Orléans; Université de Lisbonne. Accessed December 07, 2019. http://www.theses.fr/2009ORLE2038.

MLA Handbook (7th Edition):

Simão, Ana Catarina. “Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses.” 2009. Web. 07 Dec 2019.

Vancouver:

Simão AC. Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses. [Internet] [Doctoral dissertation]. Orléans; Université de Lisbonne; 2009. [cited 2019 Dec 07]. Available from: http://www.theses.fr/2009ORLE2038.

Council of Science Editors:

Simão AC. Ancrages sélectifs sur cétohexoses de thionocarbamates cycliques : Selective anchoring of cyclic thionocarbamates on ketohexoses. [Doctoral Dissertation]. Orléans; Université de Lisbonne; 2009. Available from: http://www.theses.fr/2009ORLE2038


University of Kentucky

2. Williams, Jarrod B. The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans.

Degree: 2017, University of Kentucky

While type 2 diabetes mellitus (T2DM) is distinguished as a disorder of blood glucose homeostasis, the vast majority of patients afflicted with this disease in the US present with the entire complement of the metabolic syndrome: abdominal obesity, hypertriglyceridemia, low HDL levels, elevated blood pressure, and elevated fasting plasma glucose. Current guidelines aim to treat each of these disorders, but do so individually even though they are manifestations of common pathologies. In other words, a patient will be prescribed different medications for diabetes, blood pressure, CVD prevention, etc., while the only single treatment aimed at the myriad of disorders together is changes to dietary and exercise habits. Diet and exercise, when executed properly, has been shown consistently to be the most effective treatment for T2DM. The rate of type 2 diabetes in the US is close to 10%, but the rate of type 2 diabetes is even higher in patients with Prader-Willi Syndrome (a genetic disease that causes excessive weight gain from overeating, resulting in approximately double the risk of diabetes). BSN272 is a combination of 2 molecules (D-tagatose and trans-polydatin) that have shown benefits in treating individual manifestations of the metabolic syndrome presentation as monotherapy and have proved synergistic when taken together to treat the entire complement of the disorders. Previous research in our lab with D-tagatose included safety studies in animal models and humans for use as a dietary ingredient which culminated with the generally recognized as safe (GRAS) designation by the FDA and EU for use in foods. Based on these exposures to determine safety, an IND was granted to evaluate the safety and efficacy of D-tagatose in treating hyperglycemia in T2DM. Phase 2 and 3 global clinical trials were completed showing D-tagatose to be highly safe and moderately effective. The decision was made to search for a molecular complement to D-tagatose that could more completely treat T2DM. Dihydromyricetin and trans-polydatin were identified through literature searches as potentially synergistic with D-tagatose. Both molecules were tested in combination with D-tagatose for their ability to prevent diet-induced elevations in cholesterol markers in ApoE-/- mice. Dihydromyricetin appeared to be additively effective with D-tagatose for lipids, but transpolydatin showed synergy in prevention of cholesterol elevations as results were greater for the combination than were the additive benefits of either as monotherapy. Trans-polydatin also showed this property in a hyperlipidemic hamster model and a LDLr-/- mouse model. Following safety and efficacy results in three animal models for BSN272, an exploratory Phase 1 PK microdose study was submitted to the FDA in an IND filing to investigate whether the presence of D-tagatose has any effects on the kinetics of trans-polydatin when administered in concert compared to trans-polydatin alone. The indication sought for the IND is Prader-Willi Syndrome (PWS) due to the added potential of D-tagatose…

Subjects/Keywords: Polydatin; piceid; D-tagatose; tagatose; type 2 diabetes; Prader-Willi syndrome; Endocrinology, Diabetes, and Metabolism; Pharmacy Administration, Policy and Regulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Williams, J. B. (2017). The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacy_etds/69

Chicago Manual of Style (16th Edition):

Williams, Jarrod B. “The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans.” 2017. Doctoral Dissertation, University of Kentucky. Accessed December 07, 2019. https://uknowledge.uky.edu/pharmacy_etds/69.

MLA Handbook (7th Edition):

Williams, Jarrod B. “The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans.” 2017. Web. 07 Dec 2019.

Vancouver:

Williams JB. The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans. [Internet] [Doctoral dissertation]. University of Kentucky; 2017. [cited 2019 Dec 07]. Available from: https://uknowledge.uky.edu/pharmacy_etds/69.

Council of Science Editors:

Williams JB. The Development of BSN272 From Prevention of Diet-Induced Hyperlipidemia in Mice to a Potential Therapy For Prader-Willi Syndrome in Humans. [Doctoral Dissertation]. University of Kentucky; 2017. Available from: https://uknowledge.uky.edu/pharmacy_etds/69


Brno University of Technology

3. Jurečková, Zuzana. Prebiotické sladidlo tagatosa .

Degree: 2010, Brno University of Technology

Toto sladidlo D-tagatosa, má četné výhody, které by se časem i u nás mohly využívat v potravinovém průmysle. Jsou zde shrnuty vlastnosti D-tagatosy, fyzikální také chemické a možnosti výroby D-tagatosy. V základních informacích o vlastnostech se také pojednává o samotném metabolismu D-tagatosy a jejich prebiotických vlastnostech v trávicím traktu. D-tagatosa je nově navržené náhradní sladidlo, také proto nesmí chybět možnost aplikace D-tagatosy v potravinách jako jsou např. cukrovinky. Vlastnosti D-tagatosy jsou porovnány se sladivostí klasického cukru. Nedílnou součástí je také možnost stanovení D-tagatosy v potravinách různými metodami a technikami.; This sweetener, D-tagatose, has numerous advantages, which would eventually be able to use in the food industry. It summarizes the properties of Dtagatose, physical and also chemical, the possibility of production from lactose or bacterial action on Dtalitol. The basic information about the properties of Dtagatosy also discusses the actual metabolism of Dtagatose, prebiotic properties and their effect in the gastrointestinal tract. Dtagatose is a proposed new sweetener, because the possibility can not be missed in certain applications tagatose in a different types of foods for example confectionery. And positive qualities in comparison with sucrose. This comparison is made to examples of disease associated with excessive use of conventional sweeteners sucrose. This paper also discusses possibilities Dtagatose determination in foods by different methods. Advisors/Committee Members: Vespalcová, Milena (advisor).

Subjects/Keywords: D-tagatosa; náhradní sladidla; monosacharid; ketohexosa; Maillardovy reakce; výroba D-tagatosy; Salivanůw test; Acetobacter suboxydans; metabolismus D-tagatosy; metabolismus D-fruktosy; prebiotikum; obezita; diabetes; mellitus; zubní kaz; D-tagatose; sweeteners; monosacharides; ketohexose; Maillard´s reaction; production of D-tagatose; Salivan´s test; Acetobacter suboxydans; metabolism of D-tagatose; metabolism of D-fructose; prebiotic; obesity; diabetes; tooth decay

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jurečková, Z. (2010). Prebiotické sladidlo tagatosa . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/7254

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jurečková, Zuzana. “Prebiotické sladidlo tagatosa .” 2010. Thesis, Brno University of Technology. Accessed December 07, 2019. http://hdl.handle.net/11012/7254.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jurečková, Zuzana. “Prebiotické sladidlo tagatosa .” 2010. Web. 07 Dec 2019.

Vancouver:

Jurečková Z. Prebiotické sladidlo tagatosa . [Internet] [Thesis]. Brno University of Technology; 2010. [cited 2019 Dec 07]. Available from: http://hdl.handle.net/11012/7254.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jurečková Z. Prebiotické sladidlo tagatosa . [Thesis]. Brno University of Technology; 2010. Available from: http://hdl.handle.net/11012/7254

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.