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You searched for subject:(Cytochrome P4501A2). Showing records 1 – 2 of 2 total matches.

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Universitat Pompeu Fabra

1. Fonseca Casals, Francina. Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals.

Degree: Departament de Ciències Experimentals i de la Salut, 2010, Universitat Pompeu Fabra

Els programes de manteniment amb metadona (PMM) han demostrat eficàcia en el tractament del trastorn per dependència d'opiacis malgrat la persistència de pacients amb mala resposta al tractament. L'estudi dels factors farmacodinàmics i farmacocinètics implicats en la resposta terapèutica ofereix resultats controvertits. L'objectiu de la tesi doctoral que es presenta és estudiar els factors farmacodinàmics i farmacocinètics de la metadona que poden estar implicats en l'eficàcia del tractament. S'han inclòs pacients ambulatoris diagnosticats de trastorn per dependència d'opiacis (segons criteris DSM-IV) en PMM. Els pacients s'han avaluat a nivell clínic i s'han obtingut mostres de sang per a l'estudi de les concentracions plasmàtiques de (R,S)-, (R) i (S)- metadona. S'han estudiat també les variants al·lèliques dels gens que codifiquen per: BDNF, OPRM1, MYOCD, mGluR6, mGluR8, CRY1, NR4A2, 1q31.2 (rs965972), 2q21.2 (rs1867898), CYP3A5, CYP2D6, CYP2B6, CYP2C9, CYP2C19 i P-glicoproteïna. La mostra s'ha dividit en responedors i no responedors en funció del nombre de controls d'orina positius per a heroïna en analítiques realitzades de forma aleatòria. Es van detectar diferències en resposta al tractament segons les variants dels gens codificants per a BDNF, MYOCD i GRM6. També es va detectar una associació entre el fenotip de CYP2D6, la resposta al tractament, la dosi requerida de metadona i les concentracions plasmàtiques. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Torrens, Marta (director), Torre Fornell, Rafael de la (director).

Subjects/Keywords: genotip; haplotip; gen resistència multisubstància (ABCB1); gen miocardina (MYOCD); gen; gen candidat; farmacogenòmica; fenotip; farmacogenètica; farmacodinàmica; farmacocinètica; estereoselectivitat; epistaxi; enzim; enantiòmer; 3-diphenyl-1-pyrrolidine; 5-dimethyl-3; 3-diphenylpyrrolidine; electroforesi; EMDP; 2-ethyl-5-methyl-3; 2-ethylidene-1; dopamina; EDDP; criptocrom 1 (CRY1); desintoxicació; comorbiditat psiquiàtrica; Citocrom P4503A5; Citocrom P4503A4; Citocrom P4502D6; Citocrom P4502B6; Citocrom P4502C19; Citocrom P4502C9; Citocrom P4501A2; Citocrom P450; biodisponibilitat; Alel; addicció; abstinència; withdrawal; vulnerability; stereoselectivity; substance abuse; single nucleotide polymorphism (SNP); psychiatric comorbidity; replacement therapy; polymorphism; pharmacogenomics; pharmacokinetics; phenotype; pharmacogenetics; pharmacodynamics; opioid dependence; opioid; opiate; neurotrophins; neurotransmitter; Myocardin gene (MYOCD); resistant gene 1 (ABCB1); multidrug; methadone; mu opioid receptor; metabotropic glutamate receptors; maintenance treatment; Isomers; heroin (diacetylmorphine); Haplotype; Genotype; gene; Epistasis; Enzyme; Enantiomer; 3-diphenyl-1-pyrrolidine; 2-ethyl-5-methyl-3; EMDP; Electrophoresis; 3-diphenylpyrrolidine; 5-dimethyl-3; dopamine; EDDP; 2-ethylidene-1; detoxification; Cytochrome P4503A5; Cytochrome P4503A4; Cytochrome P4502D6; Cytochrome P4502C9; Cytochrome P4502C19; Cytochrome P4502B6; Cytochrome P4501A2; Cytochrome P450; Cryptochrome 1 gene (CRY1); craving; Complex Disease; candidate gene; allele; Brain Derived Neurotrophic factor (BDNF); addiction; heroïna (diacetilmorfina); isòmers; metadona; neurotransmissor; neurotrofines; opiacis; polimorfisme; polimorfisme de nucleòtid únic (SNP); receptor metabotròpic del glutamat; receptor opioide mu; tractament de manteniment; tractament substitutiu; trastorn per ús de substàncies; vulnerabilitat; 615

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fonseca Casals, F. (2010). Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals. (Thesis). Universitat Pompeu Fabra. Retrieved from http://hdl.handle.net/10803/7234

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fonseca Casals, Francina. “Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals.” 2010. Thesis, Universitat Pompeu Fabra. Accessed November 29, 2020. http://hdl.handle.net/10803/7234.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fonseca Casals, Francina. “Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals.” 2010. Web. 29 Nov 2020.

Vancouver:

Fonseca Casals F. Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals. [Internet] [Thesis]. Universitat Pompeu Fabra; 2010. [cited 2020 Nov 29]. Available from: http://hdl.handle.net/10803/7234.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fonseca Casals F. Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals. [Thesis]. Universitat Pompeu Fabra; 2010. Available from: http://hdl.handle.net/10803/7234

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universidade Nova

2. Rodrigues, Patrícia Raquel dos Santos. Development of oxidoreductase based electrochemical biosensors.

Degree: 2013, Universidade Nova

Dissertação para obtenção do Grau de Mestre em Biotecnologia

This thesis is divided in 2 sections, each describing the development of an oxidoreductase based biosensor. In the first part human Cytochrome P450 1A2 (CYP1A2) electrochemistry was studied, while the second is focused on the optimization of immobilization platforms and operation methods for amperometric biosensors, using cytochrome c nitrite reductase (ccNiR), (Desulfovibrio desulfuricans ATCC 27774) as a model enzyme. The direct electrochemistry of P450s immobilized in water-based sol-gel thin films was described for the first time. The optimization of the film showed that only the combination of the inorganic matrix and the PEG400 enabled the direct electron transfer reaction and electrocatalytic activity towards oxygen. The amount of dissolved oxygen in solution revealed itself a significant feature in CYP’s electrochemistry – in anaerobic conditions, when small amounts of oxygen are added the PFeIII=II signal’s intensity increased, while in aerobic conditions it disappeared; probably PFeIII is not being regenerated. However, this was not observed with the CYPOR complex, indicating that the reductase has an essential role in the CYP’s catalytic cycle completion; this was also sustained by the fact that only in its presence organic substrates catalysis (caffeine) occurs. The hybrid sol-gel developed for CYP, was optimized for a nitrite biosensor. ccNiR was successfully incorporated while promptly displaying catalytic currents. Although the bioelectrode’s response decreases after day one, it was able to maintain a reasonable catalytic activity over a time span of 2 weeks. Another electrode modification strategy, studied with ccNiR, was based on the electrophoretic deposition of macroporous assemblies of single-walled carbon nanotubes. The macroporous structure was created as a result of the presence of polystyrene beads co-deposited with the carbon nanotubes. An increase in the amount of material was correlated with a higher enzyme activity. Finally, an oxygen scavenger system consisting of glucose oxidase, glucose, and catalase was employed for oxygen removal in an open electrochemical cell. The system completely removed oxygen for over 1 h and was successfully applied to a ccNiR based nitrite sensor.

Advisors/Committee Members: Almeida, Maria Gabriela, Pereira, Sofia.

Subjects/Keywords: Biosensors; Cytochrome c nitrite reductase; Cytochrome P4501A2; Sol-gel; Carbon nanotubes; Electrophoretic deposition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rodrigues, P. R. d. S. (2013). Development of oxidoreductase based electrochemical biosensors. (Thesis). Universidade Nova. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rodrigues, Patrícia Raquel dos Santos. “Development of oxidoreductase based electrochemical biosensors.” 2013. Thesis, Universidade Nova. Accessed November 29, 2020. https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rodrigues, Patrícia Raquel dos Santos. “Development of oxidoreductase based electrochemical biosensors.” 2013. Web. 29 Nov 2020.

Vancouver:

Rodrigues PRdS. Development of oxidoreductase based electrochemical biosensors. [Internet] [Thesis]. Universidade Nova; 2013. [cited 2020 Nov 29]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rodrigues PRdS. Development of oxidoreductase based electrochemical biosensors. [Thesis]. Universidade Nova; 2013. Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.