subject:(Cross coupling reaction)

1. Geogheghan, Katherine Jayne. Boronic acid speciation in Suzuki-Miyaura cross-coupling.

Degree: PhD, 2018, University of Edinburgh

► Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed… (more)

▼ Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed coupling of an organoboron and organohalide compounds proceeds through a three-stage mechanism of oxidative addition, transmetalation and reductive elimination. The transmetalation of boronic acids to a palladium(II) complex has been widely studied. However, very little is known about the transmetalation of boronic esters, which are commonly used as an alternative to unstable boronic acids. Whether these species undergo direct transmetalation or prior hydrolysis to the boronic acid under SM conditions remains unknown. This research aimed to elucidate the mechanism of this cross-coupling process. Initial results under typical SM conditions created a biphasic reaction, promoted by the inorganic base and solvent composition, and showed that the boronic esters and corresponding boronic acid couple at the same absolute rate. This is thought to be a consequence of the formation of a biphasic mixture, rendering phase transfer the turnover-limiting step. The conditions were thus adapted to maintain a monophasic system using an organic soluble base, 2-tert-butyl-1,1,3,3-tetramethylguanidine, enabling the focus to be transmetalation as the turnover-limiting step. These new conditions show a significant difference in both reaction rate and induction period when using a boronic ester compared to the corresponding boronic acid. The use of guanidine was also shown to have an interesting effect on the boronic acid/ester species by 19F and 11B NMR. Further studies found the use of guanidine to create a boronate species, with this species being an aryl trihydroxyboronate or the hydroxyl"ate"-complex of the boronic ester, depending on the presence of diol in the system. Formation of a boronate species was found to be crucial for efficient cross-coupling. When testing weaker bases, unable to form a boronate species, poor SM cross-coupling conversion was found using the newly developed phosphine-free guanidine conditions, showing the importance of the boronate species under these conditions. The results suggest that depending on the strength of base used, the pathway of transmetalation pathway can be switched, between the boronate pathway and the oxo-palladium pathway, under the specific conditions developed.

Subjects/Keywords: 660; cross-coupling; Suzuki-Miyaura reaction; palladium catalysed coupling; boronic esters

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APA (6^th Edition):

Geogheghan, K. J. (2018). Boronic acid speciation in Suzuki-Miyaura cross-coupling. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/33092

Chicago Manual of Style (16^th Edition):

Geogheghan, Katherine Jayne. “Boronic acid speciation in Suzuki-Miyaura cross-coupling.” 2018. Doctoral Dissertation, University of Edinburgh. Accessed March 04, 2021. http://hdl.handle.net/1842/33092.

MLA Handbook (7^th Edition):

Geogheghan, Katherine Jayne. “Boronic acid speciation in Suzuki-Miyaura cross-coupling.” 2018. Web. 04 Mar 2021.

Vancouver:

Geogheghan KJ. Boronic acid speciation in Suzuki-Miyaura cross-coupling. [Internet] [Doctoral dissertation]. University of Edinburgh; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1842/33092.

Council of Science Editors:

Geogheghan KJ. Boronic acid speciation in Suzuki-Miyaura cross-coupling. [Doctoral Dissertation]. University of Edinburgh; 2018. Available from: http://hdl.handle.net/1842/33092

University of Arizona

2. Bell, Christan Elizabeth. Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds .

Degree: 2012, University of Arizona

URL: http://hdl.handle.net/10150/265557

► This research focused on the synthesis of novel ogranoboron reagents in efforts to perform a variety of synthetic transformations, and additionally, the development of new… (more)

▼ This research focused on the synthesis of novel ogranoboron reagents in efforts to perform a variety of synthetic transformations, and additionally, the development of new methodologies to generate drug-like scaffolds. Initially, three novel tripod ligands were synthesized, and two were effectively chelated to boron to provide the desired organoborates. Such organoborates were employed in nucleophilic additions where they were found to be ineffective, whereas some activity was observed in Suzuki-Miyaura cross-coupling reactions. An additional project on organoboron compounds was conducted and focused on the development of organoboron frustrated Lewis pairs (FLPs) to facilitate the storage and transfer of hydrogen, nucleophilic addition reactions, and Claisen rearrangements. A new method for synthesizing a pyrrolidine diol unit was accomplished, and this intermediate was utilized to synthesize two FLPs. The reactivity of the FLPs with small molecules was assessed, and the pyrrolidine diol unit was subsequently evaluated for its ability to undergo a multicomponent reaction (MCR) to yield compounds possessing beneficial biological activity. Further research in this area was conducted, and a 5-aminoimidazole scaffold was synthesized employing a new MCR which is more efficient than previously reported methodologies. 5-Aminoimidazoles are frequently found in compounds which possess desirable biological activity, and this novel method was employed to generate a library of eleven 5-aminoimidazoles. Additionally, two post condensation modification reactions were developed. During initial studies, a side product was observed which was identified as a dihydrotriazine, which is another biologically appealing chemotype. Therefore, an enhanced method of synthesizing this product was developed, and a library of eleven dihydrotriazines was produced. In summary, novel organoboron reagents were synthesized, and their activity was evaluated. The pyrrolidine diol utilized to synthesize FLPs was applied towards an MCR. Furthermore, a novel MCR was developed for the synthesis of 5-aminoimidazoles, and an enhanced protocol for the synthesis of dihydrotriazines was found. Advisors/Committee Members: Hulme, Christopher (advisor), Christie, Hamish S. (committeemember), Polt, Robin L. (committeemember), Pyun, Jeffery (committeemember), Walker, F. Ann (committeemember), Lichtenberger, Dennis L. (committeemember), Hulme, Christopher (committeemember).

Subjects/Keywords: multicomponent reaction; Chemistry; cross-coupling; Frustrated Lewis pairs

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APA (6^th Edition):

Bell, C. E. (2012). Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/265557

Chicago Manual of Style (16^th Edition):

Bell, Christan Elizabeth. “Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds .” 2012. Doctoral Dissertation, University of Arizona. Accessed March 04, 2021. http://hdl.handle.net/10150/265557.

MLA Handbook (7^th Edition):

Bell, Christan Elizabeth. “Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds .” 2012. Web. 04 Mar 2021.

Vancouver:

Bell CE. Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds . [Internet] [Doctoral dissertation]. University of Arizona; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10150/265557.

Council of Science Editors:

Bell CE. Synthesis and Reactivity of New Organoboron Reagents and Development of New Methodologies for the Generation of Novel Drug-Like Scaffolds . [Doctoral Dissertation]. University of Arizona; 2012. Available from: http://hdl.handle.net/10150/265557

University of Edinburgh

3. Corrie, Thomas James Alexander. Intramolecular direct arylation.

Degree: PhD, 2017, University of Edinburgh

URL: http://hdl.handle.net/1842/28820

► The research conducted for this thesis has led to the development of an intramolecular gold-catalysed direct arylation protocol whereby tethered arenes and aryltrimethylsilanes are coupled… (more)

▼ The research conducted for this thesis has led to the development of an intramolecular gold-catalysed direct arylation protocol whereby tethered arenes and aryltrimethylsilanes are coupled (Scheme 1). In Chapter 1, the key synthetic and mechanistic studies that have ultimately led to the conception of this project are introduced. In Chapter 2, the substrate scope of intramolecular direct arylation is assessed. The reaction tolerates a wide range of substrates with tether lengths between one and five units (containing C, N and O) generating 5- to 9- membered rings. Substrates that lead to 5-membered rings (1 → 2) can tolerate a broad electronic range of substituents and proceed under the mildest reaction conditions (≤ 1 mol% catalyst, room temperature) and with excellent yields. A smaller collection of examples is demonstrated for the cyclisation to 6- and 7- membered rings (3 → 4, 5 → 6), but no heating is required and good yields are maintained throughout the series. The synthetically challenging synthesis of 8- and 9- membered rings (7 → 8, 9 → 10) is successful, albeit with slightly more forcing conditions (4 mol%, up to 50 °C). The methodology was subsequently applied in the successful 10-step synthesis of natural product allocolchicine 11. In Chapter 3, the operative reaction mechanism is elucidated. Reaction monitoring techniques allowed for the detailed study of linear free energy relationships (LFERs) and kinetic isotope effects (KIEs), which in turn allowed for deduction of the reaction turnover-limiting step (TLS) and thus the first quantitative experimental data on the effects of aryl electron demand and conformational freedom on the rate of reductive elimination from diarylgold(III) species. The mechanistic investigation led to the observation of complex kinetic profiles for specific substrates. The origin of these unusual effects is the focus of Chapter 4. By combining experiment with kinetic simulation, an off-cycle catalyst inhibition pathway was identified and the understanding of this process allowed for a re-optimisation of reaction conditions. In Chapter 5, the general kinetic parameters that could govern any domino reaction combining inter- and intramolecular direct arylation are deduced through kinetic analysis and simulation of hypothetical systems. The results of the kinetic analysis were proved experimentally through the successful combination of intra- and intermolecular gold-catalysed direct arylation. The products of intramolecular cyclisation 2, generated in-situ, are demonstrated to couple with intermolecular aryltrimethylsilanes 12, resulting in a rapid increase in molecular complexity from simple substrates in one pot.

Subjects/Keywords: gold-catalysis; cross-coupling; intermolecular reaction; tethered arenes; aryltrimethylsilanes

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APA (6^th Edition):

Corrie, T. J. A. (2017). Intramolecular direct arylation. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/28820

Chicago Manual of Style (16^th Edition):

Corrie, Thomas James Alexander. “Intramolecular direct arylation.” 2017. Doctoral Dissertation, University of Edinburgh. Accessed March 04, 2021. http://hdl.handle.net/1842/28820.

MLA Handbook (7^th Edition):

Corrie, Thomas James Alexander. “Intramolecular direct arylation.” 2017. Web. 04 Mar 2021.

Vancouver:

Corrie TJA. Intramolecular direct arylation. [Internet] [Doctoral dissertation]. University of Edinburgh; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1842/28820.

Council of Science Editors:

Corrie TJA. Intramolecular direct arylation. [Doctoral Dissertation]. University of Edinburgh; 2017. Available from: http://hdl.handle.net/1842/28820

University of South Carolina

4. Key, Ryan J. Development of Nickel Catalyzed Cross-Coupling Methodologies.

Degree: PhD, Chemistry and Biochemistry, 2019, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/5324

► In this work, we have addressed some of the issues surrounding catalytic crosscoupling reactions by using a nickel terpyridine catalyst, [Ni(tpy)(py)(CH3CN)2](PF6)2 in the Buchwald-Hartwig… (more)

Subjects/Keywords: Chemistry; nickel; cross-coupling; Atomic Layer Deposition; Suzuki reaction

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APA (6^th Edition):

Key, R. J. (2019). Development of Nickel Catalyzed Cross-Coupling Methodologies. (Doctoral Dissertation). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/5324

Chicago Manual of Style (16^th Edition):

Key, Ryan J. “Development of Nickel Catalyzed Cross-Coupling Methodologies.” 2019. Doctoral Dissertation, University of South Carolina. Accessed March 04, 2021. https://scholarcommons.sc.edu/etd/5324.

MLA Handbook (7^th Edition):

Key, Ryan J. “Development of Nickel Catalyzed Cross-Coupling Methodologies.” 2019. Web. 04 Mar 2021.

Vancouver:

Key RJ. Development of Nickel Catalyzed Cross-Coupling Methodologies. [Internet] [Doctoral dissertation]. University of South Carolina; 2019. [cited 2021 Mar 04]. Available from: https://scholarcommons.sc.edu/etd/5324.

Council of Science Editors:

Key RJ. Development of Nickel Catalyzed Cross-Coupling Methodologies. [Doctoral Dissertation]. University of South Carolina; 2019. Available from: https://scholarcommons.sc.edu/etd/5324

Indian Institute of Science

5. Dhineshkumar, J. Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions.

Degree: PhD, Faculty of Science, 2018, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/3020

► Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions” is divided into two sections. Section-A, contains two chapters, describes the catalytic ability of iodine… (more)

▼ Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions” is divided into two sections. Section-A, contains two chapters, describes the catalytic ability of iodine for cross coupling reactions. Section-B, divided into three chapters, presents the azidation of organic scaffolds under oxidative conditions. Section A Chapter 1 presents a C-H functionalization of tetrahydroisoquinolines using iodine as a catalyst under aerobic conditions.1 This methodology employs Cross Dehydrogenative Coupling (CDC) strategy as a key step, which is highly atom economical as it doesn’t require pre-functionalized starting materials.2 Owing to the importance of tetrahydroisoquinoline moiety which is present in the umpteen natural products, considerable attention has been put up to functionalize tetrahydroisoquinoline scaffold.3 Iodine a non-metal which is non-toxic was found to catalyze the C-H functionalization of tetrahydroisoquinolines with a variety of nucleophiles such as coumarin, alkyl phosphite, phenols, indoles, acetone and dialkyl malonoates were coupled to it. Significant mechanistic study has been carried out to find the possible intermediate and support the mechanistic proposal. A few representative examples are highlighted in Scheme 1.1 Synopsis Scheme 1: A CDC coupling of tetrahydroisoquinoline with variety of nucleophiles Chapter 2 describes the Cross Hetero Dehydrogenative Coupling (CHDC) reactions of amines, alcohols and sulfoximines with various phosphites.4 Phosphoramidates and phosphate esters are structural scaffolds that are present in a variety of biologically active molecules.5 The conventional methods for synthesizing phosphoramidates/phosphate esters largely involve treating alcohol/amine with appropriate phosphorus halides which generates stoichiometric amount of halogen waste.6 Due to the usage of stoichiometric reagents and difficulties associated with the reported methods, there is a need for developing a protocol which is catalytic and mild. Therefore, we developed a method which employs catalytic amount of iodine and aq. H2O2 as a sole oxidant under milder conditions. Using this methodology, variety of phosphoramidates, phosphorous triesters and sulfoximine derived Synopsis Scheme 2: Phosphorylation of amines, alcohols and sulfoximines phosphoramidates have been synthesized with great efficiency and environmentally benign conditions. A few representative examples are highlighted in Scheme 2.4 Section B Chapter 1 of Section B demonstrates a mild way of synthesizing quaternary azides from α-substituted active methylene compounds which will serve as surrogates for several unnatural amino acid derivatives.7 Azidation has emerged as one of the efficient methods to introduce nitrogen atom in to the organic molecules.8 Azides are versatile functional groups which can be converted to amine, amide, and nitro compounds by simple modification. Moreover, azides are potential handle for “click” chemistry and provide late stage modifications in drug candidates, biomolecules and… Advisors/Committee Members: Prabhu, K R (advisor).

Subjects/Keywords: Carbon-heteroatom Bond; Cross Dehydrogenative Coupling; Tetrabutylammonium Iodide; Cross-Hetero-Dehydrogenative Coupling Reaction; Phosphites; Quaternary Azides; Organic Chemistry

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APA (6^th Edition):

Dhineshkumar, J. (2018). Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3020

Chicago Manual of Style (16^th Edition):

Dhineshkumar, J. “Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed March 04, 2021. http://etd.iisc.ac.in/handle/2005/3020.

MLA Handbook (7^th Edition):

Dhineshkumar, J. “Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions.” 2018. Web. 04 Mar 2021.

Vancouver:

Dhineshkumar J. Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Mar 04]. Available from: http://etd.iisc.ac.in/handle/2005/3020.

Council of Science Editors:

Dhineshkumar J. Iodine and Copper Catalyzed Oxidative Cross Coupling Reactions : Design and Development of Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3020

NSYSU

6. Huang, Hao-ping. Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.

Degree: Master, Chemistry, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051

► The direct ortho arylation of 4-methyl-N-phenylpyridin-2-amines via palladium(II)-catalyzed C-H activation is described. Treatment of 4-methyl-N-phenylpyridin-2-amine with potassium aryltrifluoroborate using ten mol % of Pd(OAc)2 as… (more)

Subjects/Keywords: palladium; C-H bond activation; potassium aryltrifluoroborate; Suzuki-Miyaura cross-coupling reaction

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APA (6^th Edition):

Huang, H. (2013). Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Hao-ping. “Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.” 2013. Thesis, NSYSU. Accessed March 04, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Hao-ping. “Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling.” 2013. Web. 04 Mar 2021.

Vancouver:

Huang H. Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Mar 04]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang H. Palladium(II)-Catalyzed Direct Ortho Arylation of 4-Methyl-N-phenylpyridin-2-amines via Suzuki-Miyaura Type C-H Bond Activation/C-C Bond Coupling. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0406113-201051

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

7. Lee, Jack C. H. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.

Degree: PhD, Department of Chemistry, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/qn59q550n

► As Organic Chemistry evolves into the 21st Century, the goal of this discipline has altered dramatically from merely accessing target molecules to efficiently synthesizing these… (more)

▼ As Organic Chemistry evolves into the 21st Century, the goal of this discipline has altered dramatically from merely accessing target molecules to efficiently synthesizing these compounds with minimization of non-strategic functional group manipulations and interconversions. Organoboron reagents represent one of the potential solutions towards reaching this goal. These versatile compounds can either be used to construct the desired carbon−carbon bond through various cross-coupling reactions, or be converted directly to the desired functionality through different chemical reactions. Direct transformations make interconversions between different functional groups unnecessary, thus making the overall process step-economical. In this thesis, several synthetic methods were developed to synthesize chiral alkyl boronates or alkenyl boronates through metal-catalyzed chemical transformations. These methodologies are based on early introduction strategy which applies well-established synthetic protocols to substrates with a pre-installed boronyl moiety. The subsequent applications of these compounds were also investigated, leading to a variety of synthetically valuable adducts. In order to access novel chiral secondary alkyl boronates, catalytic asymmetric conjugate addition reactions of 3-boronyl -unsaturated esters with Grignard reagents were developed. Chapter 2 describes the details of optimization of this methodology and the applications of the chiral alkyl boronate products. Aiming to explore the intrinsic reactivity of enantioenriched 1,1-diboron compounds, their synthesis was accomplished for the first time by performing asymmetric conjugate borylation on 3-boronyl enoates. The resulting optically enriched 1,1-diboron compounds were found to be excellent cross-coupling partners in Suzuki-Miyaura cross-couplings, leading to chiral alkyl boronates with excellent enantioselectivity. The details of these studies are presented in Chapter 3. In order to conduct a thorough examination of substrate scope in asymmetric conjugate reductions of 3-boronyl-3-aryl -unsaturated esters, a diastereoselective protocol for the preparation of these alkenyl boronates through Heck coupling was developed. In Chapter 4, the optimization of the coupling process, the substrate scope, and the subsequent application of these alkenyl boronates are discussed. Due to the synthetic potential of cyclic alkenyl boronates, new methods for their efficient synthesis are desirable. In Chapter 5, the preparation of novel cyclic alkenyl boronates through gold-catalyzed enyne cycloisomerizations is presented.

Subjects/Keywords: Gold-catalyzed cycloisomerization; Suzuki-Miyaura cross-coupling; Chiral alkyl boronates; Heck reaction; Enantioselective conjugate addition

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APA (6^th Edition):

Lee, J. C. H. (2013). Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/qn59q550n

Chicago Manual of Style (16^th Edition):

Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.” 2013. Doctoral Dissertation, University of Alberta. Accessed March 04, 2021. https://era.library.ualberta.ca/files/qn59q550n.

MLA Handbook (7^th Edition):

Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.” 2013. Web. 04 Mar 2021.

Vancouver:

Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Mar 04]. Available from: https://era.library.ualberta.ca/files/qn59q550n.

Council of Science Editors:

Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/qn59q550n

University of KwaZulu-Natal

8. Molefe, Patience Snenhlanhla Sthembile. Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones.

Degree: 2018, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18146

► Asymmetric biaryl ketones are important building block in organic chemistry since they occur in large number of biological active compounds, natural product, cosmetics as well… (more)

▼ Asymmetric biaryl ketones are important building block in organic chemistry since they occur in large number of biological active compounds, natural product, cosmetics as well as in organic synthesis. The aim of this project was to develop a novel base-free Suzuki-Miyaura cross-coupling of biaryl ketones from sodium (aryl trihydroxyborate) salts coupled with acyl chlorides catalysed by palladium precursor and investigate the electron effect of substituents attached to acyl chloride and sodium (aryl trihydroxyborate) salts on the yields of ketones produced. A novel synthesis of biaryl ketones was successfully developed in coupling of commercially available substituted acyl chlorides with easily accessible substituted sodium (aryl trihydroxyborate) salts catalysed by Pd(PPh3)4 in aqueous toluene. A wide range of functional groups were accommodated including CF3, OMe, SMe, Br, F, NO2, OH, NH2 yielding up to 96% in 24 hours. Encouraged by successful cross-coupling reaction between sodium (aryl trihydroxyborate) salts and acyl chlorides under the Suzuki-Miyaura cross-coupling acylation reaction conditions, we thought it would be logical to extend the scope of the developed reaction condition to include carboxylic anhydrides as electrophiles. As a result, substituted benzoic anhydrides were first synthesised following previously published procedures giving the desired products in excellent yields (87-99%). The synthesised carboxylic anhydrides were subsequently cross-coupled with boronate salts under base-free and ligandless palladium catalysed cross-coupling reaction conditions to synthesise biaryl ketones in aqueous acetone. The developed method appears sensitive to electronic effects both on the electrophile and on the nucleophile and on the nucleophile furnishing the desired ketones in moderate yields. Two novel methods have been developed to synthesise ketones from stable, easy to prepare and free flowing pure sodium (aryl trihydroxyborate) salts. Advisors/Committee Members: Sithebe, Siphamandla. (advisor).

Subjects/Keywords: Base-free Suzuki.; Sodium salts.; Aryl trihydroxyborate.; Ketones.; Suzuki-Miyaura cross-coupling acylation reaction.

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APA (6^th Edition):

Molefe, P. S. S. (2018). Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Molefe, Patience Snenhlanhla Sthembile. “Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones.” 2018. Thesis, University of KwaZulu-Natal. Accessed March 04, 2021. https://researchspace.ukzn.ac.za/handle/10413/18146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Molefe, Patience Snenhlanhla Sthembile. “Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones.” 2018. Web. 04 Mar 2021.

Vancouver:

Molefe PSS. Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Mar 04]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Molefe PSS. Base-Free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: a novel synthesis of substituted aryl ketones. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/18146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Urgin, Karene. Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic.

Degree: Docteur es, Chimie organique, minérale, industrielle, 2010, Université Paris-Est

URL: http://www.theses.fr/2010PEST1094

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Les hétérocycles aromatiques sont des motifs structuraux rencontrés dans un grand nombre de substances d'intérêts biologiques ou pharmacologiques. Plus particulièrement, les pyridazines substituées font l'objet… (more)

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Les hétérocycles aromatiques sont des motifs structuraux rencontrés dans un grand nombre de substances d'intérêts biologiques ou pharmacologiques. Plus particulièrement, les pyridazines substituées font l'objet d'un intérêt grandissant pour leurs propriétés pharmaceutiques (antibactériens, anti-inflammatoires, médicaments cardiovasculaires…). De plus, les structures comportant des pyridazines peuvent également être utilisées en tant qu'agents chélatants de cations métalliques et s'ordonner en édifices utilisés en chimie supramoléculaire.Nous nous sommes donc intéressés à l'élaboration d'éléments de base comportant des cycles pyridaziniques de type aryl ou hétéroarylpyridazines. La mise au point de méthodes impliquant des espèces organométalliques a été l'un de nos objectifs primordial. L'élaboration de ces composés a été réalisée par formation de liaisons C-C. Une approche électrochimique d'hétérocouplage associé à une catalyse au nickel a été utilisée. Quelques limites à cette méthode ont cependant été observées dans le cas des couplages mettant en jeu des 3,6-dihalogénopyridazines. Une étude par électrochimie analytique a permis d'en comprendre les raisons. La seconde partie de notre travail a consisté en l'étude de la réactivité d'arylzinciques ou de triarylbismuths vis-à-vis de 3,6-dihalogénopyridazines

Heteroaromatic rings are present in various biological and pharmacological active molecules. Substituted aryl-pyridazines have given rise to considerable interest because of their diverse pharmacological properties (antibacterial, anti-inflammatory, cardiovascular drugs…). Moreover, structures which contain pyridazines are used in supramolecular chemistry for their applications through self-assembly processes in the presence of metal ions.In order to elaborate building blocks containing pyridazine rings such as aryl or heteroaryl-pyridazines, we turned our intention on the development of complementary methods involving organometallic reagents. Transition metal-catalyzed cross-coupling reaction of organometallic compounds with organic halides is one of the most powerful methods for the generation of C-C bonds.We chose to develop the most straightforward method involves heterocoupling reaction of aryl/heteroaryl compounds under electrochemical conditions (sacrificial anode process) associated to a nickel catalysis. However some limitations have been pointed out when 3,6-dihalogenopyridazines are involved in the cross-coupling reaction. An electrochemical study was investigated in order to propose some mechanistic considerations. A second part of this work consisted in the study of arylzinc and triarylbismuths reagents toward 3,6-dihalogenopyridazines

Advisors/Committee Members: Condon, Sylvie (thesis director).

Subjects/Keywords: Pyridazine; Couplage; Electrosynthèse; Organozinciques; Triarylbismuths; Palladium; Pyridazine; Cross-coupling reaction; Electrosynthesis; Organozinc compounds; Triarylbismuths; Palladium

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Urgin, K. (2010). Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2010PEST1094

Chicago Manual of Style (16^th Edition):

Urgin, Karene. “Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic.” 2010. Doctoral Dissertation, Université Paris-Est. Accessed March 04, 2021. http://www.theses.fr/2010PEST1094.

MLA Handbook (7^th Edition):

Urgin, Karene. “Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic.” 2010. Web. 04 Mar 2021.

Vancouver:

Urgin K. Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic. [Internet] [Doctoral dissertation]. Université Paris-Est; 2010. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2010PEST1094.

Council of Science Editors:

Urgin K. Préparation de dérivés aryl- et hétéroaryl- pyridazine(s) par voies organométalliques chimiques ou électrochimiques : Preparation of heteroaryl and aryl pyridazine derivatives by organometallic. [Doctoral Dissertation]. Université Paris-Est; 2010. Available from: http://www.theses.fr/2010PEST1094

Boston College

10. Zhang, Liang. Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions.

Degree: PhD, Chemistry, 2017, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:107561

► This dissertation will present four main projects focused on stereoselective construction of borylated compounds as well as their applications in asymmetric syntheses. The first two… (more)

Subjects/Keywords: boron-Wittig reaction; catalytic conjunctive cross-coupling; catalytic diboration; enantioselective synthesis; organoboronates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, L. (2017). Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:107561

Chicago Manual of Style (16^th Edition):

Zhang, Liang. “Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions.” 2017. Doctoral Dissertation, Boston College. Accessed March 04, 2021. http://dlib.bc.edu/islandora/object/bc-ir:107561.

MLA Handbook (7^th Edition):

Zhang, Liang. “Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions.” 2017. Web. 04 Mar 2021.

Vancouver:

Zhang L. Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions. [Internet] [Doctoral dissertation]. Boston College; 2017. [cited 2021 Mar 04]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107561.

Council of Science Editors:

Zhang L. Catalytic Conjunctive Cross-Coupling and Catalytic Diboration Reactions. [Doctoral Dissertation]. Boston College; 2017. Available from: http://dlib.bc.edu/islandora/object/bc-ir:107561

11. D'Attoma, Joseph. Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.

Degree: Docteur es, Chimie, 2013, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2013LYO10243

►

Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité… (more)

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Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité des ALCL est issue d'une translocation t(2;5)(p23;q35) donnant lieu à la formation d'une protéine de fusion appelée NPM-ALK. A ce jour, peu d'inhibiteurs présentent de bonnes activités contre cette protéine chimérique. L'obésité représente un problème socio-médical d'envergure, à la fois pour ses effets directs et indirects ; le surpoids étant un facteur primaire dans de nombreuses maladies, tout particulièrement les diabètes, les accidents cardiovasculaires, le cancer, etc. A contrario, une restriction calorique (RC) est associée à des bénéfices importants en terme de santé. A l'issue de plusieurs criblages, un inhibiteur au motif 2-acylaminothiazole a montré une activité anticancéreuse sur ALK mais également la faculté de mimer la restriction calorique chez C. Elegans. Par conséquent, les travaux de recherche réalisés lors de cette thèse ont concerné la synthèse d'inhibiteurs comportant le squelette 2-acylaminothiazole. Les chromatographies d'affinité effectuées sur deux de nos inhibiteurs ont permis l'identification de cibles principales potentielles dans le cadre de la restriction calorique et des cibles secondaires possibles pour NPM-ALK. Ensuite, la présence d'un atome de brome sur le cycle aromatique a mené à la formation de liaisons C(sp2)-C(sp2), C(sp2)-C(sp) et C(sp2)- N, en utilisant les couplages catalysés par le palladium. Les différentes méthodes de modulation chimique ont conduit à mettre en place une librairie de 134 molécules. Certains d'entres eux et plus précisément ceux possédant un atome de silicium ont démontré une très bonne activité contre ALK et son mutant L1196M. Enfin, des résultats préliminaires ont également été obtenus sur le sujet de la restriction calorique avec quatre composés montrant une réduction du taux de lipides chez C. Elegans

Anaplastic Large-Cell Lymphoma (ALCL) is a type of cancer belonging to the non-Hodgkin family. The majority of ALCL arises from a translocation t(2;5) (p23;35) which leads to the formation of a fusion protein called NPM-ALK. Nowadays, few molecules are known to inhibit the activity of this chimeric protein. Obesity is a major socio-medical problem, for both direct and indirect effects, overweight is a primary factor in many diseases, especially diabetes, cardiovascular events, cancer, etc... In contrast, caloric restriction (CR) is associated with significant benefits in terms of health. After several screenings, one inhibitor based on a 2-acylaminothiazol scaffold showed anticancer activity on the protein ALK but also the ability to mimic caloric restriction in C. Elegans. The aim of this PhD was to develop the synthesis of new inhibitors including the 2-acylaminothiazol scaffold. The affinity chromatography performed on two of our inhibitors was used to identify potential major cellular targets in the process of caloric restriction and secondary cellular targets for NPM-ALK.…

Advisors/Committee Members: Goekjian, Peter (thesis director).

Subjects/Keywords: 2-acylaminothiazoles; Restriction calorique; ALCL; NPM-ALK; Réaction de Suzuki- Miyaura; Réaction de Buchwald-Hartwig; Réaction de Sonogashira; 2-acylaminothiazols; Caloric restriction; ALCL; NPM-ALK; Suzuki-Miyaura crosscoupling reaction; Buchwald-Hartwig cross-coupling reaction; Sonogashira cross-coupling reaction; 547

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

D'Attoma, J. (2013). Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2013LYO10243

Chicago Manual of Style (16^th Edition):

D'Attoma, Joseph. “Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.” 2013. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed March 04, 2021. http://www.theses.fr/2013LYO10243.

MLA Handbook (7^th Edition):

D'Attoma, Joseph. “Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction.” 2013. Web. 04 Mar 2021.

Vancouver:

D'Attoma J. Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013LYO10243.

Council of Science Editors:

D'Attoma J. Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique : Design, synthesis and biological evaluations of inhibitors double target : ALK and caloric restriction. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2013. Available from: http://www.theses.fr/2013LYO10243

Kyoto University

12. Agata, Ryosuke. Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis .

Degree: 2019, Kyoto University

URL: http://hdl.handle.net/2433/242522

Subjects/Keywords: Iron catalyst; Cross-coupling reaction; Natural product; Mechanistic study

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Agata, R. (2019). Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/242522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Agata, Ryosuke. “Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis .” 2019. Thesis, Kyoto University. Accessed March 04, 2021. http://hdl.handle.net/2433/242522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Agata, Ryosuke. “Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis .” 2019. Web. 04 Mar 2021.

Vancouver:

Agata R. Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis . [Internet] [Thesis]. Kyoto University; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2433/242522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Agata R. Development of Iron-Catalyzed Selective Cross-Coupling Reactions toward Natural Product Synthesis . [Thesis]. Kyoto University; 2019. Available from: http://hdl.handle.net/2433/242522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Paris-Sud – Paris XI

13. Roche, Maxime. Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4.

Degree: Docteur es, Chimie thérapeutique, 2014, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2014PA114843

►

Les travaux rapportés dans ce mémoire concernent le développement de nouveaux couplages pallado-catalysés de N-tosylhydrazones ainsi que leurs applications à la synthèse d’analogues de l’isocombrétastatine… (more)

▼

Les travaux rapportés dans ce mémoire concernent le développement de nouveaux couplages pallado-catalysés de N-tosylhydrazones ainsi que leurs applications à la synthèse d’analogues de l’isocombrétastatine A4 (isoCA-4). La première partie du manuscrit est consacrée à l’étude de la réactivité de N-tosylhydrazones encombrées dans les couplages avec des halogénures d’aryle. Des conditions ont été mise au point afin d’avoir accès à des molécules 1,1-diaryléthylène ortho/ortho’-disubstituées en relation avec l’isoCA-4. Une autre partie de ce travail est dédiée au développement de réactions tandem impliquant une N-tosylhydrazone. Deux nouvelles transformations sont rapportées, une réaction tandem couplage de Barluenga-couplage de Buchwald-Hartwig, ainsi qu’une réaction tandem couplage de Barluenga-couplage de Suzuki-Miyaura. Dans le dernier chapitre, le couplage oxydatif d’indoles avec les N-tosylhydrazones a été examiné. Les N-vinylindoles synthétisés par ce couplage ont démontré des activités antiprolifératives prometteuses.

This thesis work concerns the development of new palladium catalyzed cross-coupling reactions of N-tosylhydrazones and their applications to the synthesis of isocombretastatin A4 (isoCA-4) analogs. The first part of this work is dedicated to the study of the reactivity of hindered N-tosylhydrazones in coupling with aryl halides. A protocol has been developed to synthesize ortho/ortho’-disubstituted 1,1-diarylethylenes related to isoCA-4. Another part of this thesis is dedicated to the development of tandem reactions involving N-tosylhydrazones. Two new reactions are reported, a Barluenga cross coupling-Buchwald-Hartwig cross coupling tandem reaction as well as a Barluenga cross coupling-Suzuki-Miyaura cross coupling tandem reaction. In the last chapter, oxidative coupling of indoles with N-tosylhydrazones was examined. N-vinylindoles synthesized by this way showed promising antiproliferative activities.

Advisors/Committee Members: Hamzé, Abdallah (thesis director).

Subjects/Keywords: Combrétastatine; Antivasculaire; N-tosylhydrazone; Couplage pallado-catalysé; Réaction tandem; Couplage oxydatif; Combretastatin; Antivascular; N-tosylhydrazone; Palladium catalyzed cross-coupling; Tandem reaction; Oxidative coupling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roche, M. (2014). Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2014PA114843

Chicago Manual of Style (16^th Edition):

Roche, Maxime. “Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4.” 2014. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed March 04, 2021. http://www.theses.fr/2014PA114843.

MLA Handbook (7^th Edition):

Roche, Maxime. “Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4.” 2014. Web. 04 Mar 2021.

Vancouver:

Roche M. Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2014. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2014PA114843.

Council of Science Editors:

Roche M. Couplages pallado-catalysés de N-tosylhydrazones : synthèse d’oléfines apparentées à l’isocombrétastatine A4 : Palladium catalyzed coupling of N-tosylhydrazones : synthesis of olefines related to isocombretastatin A4. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2014. Available from: http://www.theses.fr/2014PA114843

University of Gothenburg / Göteborgs Universitet

14. Kleimark, Jonatan. MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS.

Degree: 2011, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/27967

► Transition metal catalyzed reactions have had a large impact on the human progress for the last century. Several extremely important areas, such as the agricultural… (more)

▼ Transition metal catalyzed reactions have had a large impact on the human progress for the last century. Several extremely important areas, such as the agricultural industry and the plastic industry, have benefited from this development. The evolution of different transition metal catalysts has also been very important for the pharmaceutical industry. One vital factor when developing new and more effective catalysts is to obtain mechanistic insights. In this thesis, several different methods to investigate mechanisms for transition metal catalyzed reactions are presented. The factors controlling regioselectivity for a palladium catalyzed allylic alkylation has been studied. Pre-formed (η3-allyl)Pd complexes were used to minimize dynamic processes. In the study it was found that the regioselectivity depends mainly on steric interactions, rather than electronic effects. For complexes with less steric hindrance, the trans effect controlls the selectivity. Furthermore, the mechanism for a sulfinyl nucleophile, employed in the same type of reaction, has been studied and the mode of attack has been revealed. The importance of a fast palladium catalyzed Mislow-Braverman-Evans rearrangement to ensure that the correct product was formed, was also disclosed. The important Mizoroki-Heck reaction has been investigated in two different studies. The first study revealed the mechanistic pathway for a Pd(II) catalyzed domino Mizoroki-Heck-Suzuki diarylation reaction. The dependence of benzoquinone as the re-oxidant, in order to achieve the diarylation product, was explained by its ability to coordinate to the palladium moiety, thereby allowing access to a new low-energy pathway to the product. In the second study, a new and mild nickel catalyzed variant of the Mizoroki-Heck reaction was presented and the mechanistic pathway for the reaction was introduced. In addition to this, the reasons for several unsuccessful conditions and additives were uncovered. The development of new, environmentally more benign, catalysts for cross coupling reactions is important. Iron is one of the most promising metals for this purpose, but the mechanistic knowledge of this reaction is still not comprehensive. In this thesis, several mechanistic and computational studies reveal new insights into this reaction, paving the way to develop new and more effective catalysts and conditions for the reaction.

Subjects/Keywords: alkene insertion; allylic alkylation; catalysis; cross coupling; density funtional theory; free energy surface; iron; kinetic investigation; Mizoroki-Heck reaction; nickel; palladium; reaction mechanism; sulfinylation; transition metal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kleimark, J. (2011). MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/27967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kleimark, Jonatan. “MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS.” 2011. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 04, 2021. http://hdl.handle.net/2077/27967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kleimark, Jonatan. “MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS.” 2011. Web. 04 Mar 2021.

Vancouver:

Kleimark J. MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2077/27967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kleimark J. MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. Available from: http://hdl.handle.net/2077/27967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Satou, Motoi. Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis .

Degree: 2018, Kyoto University

URL: http://hdl.handle.net/2433/232048

Subjects/Keywords: Poly(ethylene glycol); Ligand Development; Transition Metal Catalyst; Oxidation Reaction; Cross-Coupling Reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Satou, M. (2018). Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/232048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Satou, Motoi. “Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis .” 2018. Thesis, Kyoto University. Accessed March 04, 2021. http://hdl.handle.net/2433/232048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Satou, Motoi. “Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis .” 2018. Web. 04 Mar 2021.

Vancouver:

Satou M. Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis . [Internet] [Thesis]. Kyoto University; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2433/232048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Satou M. Synthesis of Ligands Bearing Poly(ethylene glycol) Chains and Their Application in Catalysis . [Thesis]. Kyoto University; 2018. Available from: http://hdl.handle.net/2433/232048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Weeden, Jason. Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions.

Degree: 2013, University of Nevada – Reno

URL: http://hdl.handle.net/11714/3132

► This dissertation investigates the ability of the phosphine 1,3,5-triaza-7-phosphaadamantane (PTA) and derivatives to serve as either organocataysts or ancillary ligands coordinated to transition metal catalysts.… (more)

Subjects/Keywords: 1; 3; 5-triaza-7-phophaadamantane (PTA); Henry (Nitroaldol) Reaction; Morita-Baylis-Hillman Reaction; Nitrile Hydration; Ruthenium Arene Piano stool complexes; Suzuki Cross-Coupling

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APA (6^th Edition):

Weeden, J. (2013). Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/3132

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weeden, Jason. “Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions.” 2013. Thesis, University of Nevada – Reno. Accessed March 04, 2021. http://hdl.handle.net/11714/3132.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weeden, Jason. “Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions.” 2013. Web. 04 Mar 2021.

Vancouver:

Weeden J. Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions. [Internet] [Thesis]. University of Nevada – Reno; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11714/3132.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weeden J. Organic and Organometallic Catalysts for Aqueous Nitrile Hydration and Carbon-Carbon Bond Forming Reactions. [Thesis]. University of Nevada – Reno; 2013. Available from: http://hdl.handle.net/11714/3132

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Africa

17. Paumo, Hugues Kamdem. 2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties .

Degree: 2014, University of South Africa

URL: http://hdl.handle.net/10500/14197

► The 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were prepared in a single-pot operation by condensing 6,8-dibromoanthranilamide and aryl aldehydes in the presence of molecular iodine in ethanol. Treatment of the… (more)

Subjects/Keywords: 2-aryl-6,8-dibromoquinazolin-4(3H)-ones; 2-aryl-4-chloro-6; 8-dibromoquinazolines; 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines; 2,6,8-triaryl-4-(phenylethynyl)quinazolines; Sonogashira cross-coupling reaction; Suzuki-Miyaura cross-coupling reaction; Absorption and emission properties

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paumo, H. K. (2014). 2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties . (Masters Thesis). University of South Africa. Retrieved from http://hdl.handle.net/10500/14197

Chicago Manual of Style (16^th Edition):

Paumo, Hugues Kamdem. “2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties .” 2014. Masters Thesis, University of South Africa. Accessed March 04, 2021. http://hdl.handle.net/10500/14197.

MLA Handbook (7^th Edition):

Paumo, Hugues Kamdem. “2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties .” 2014. Web. 04 Mar 2021.

Vancouver:

Paumo HK. 2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties . [Internet] [Masters thesis]. University of South Africa; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10500/14197.

Council of Science Editors:

Paumo HK. 2-Aryl-6,8-Dibromo-4-Chloroquinazoline as scaffold for the synthesis of Novel 2,6,8-Triaryl-4-(Phenylethynyl)Quinazolines with potential photophysical properties . [Masters Thesis]. University of South Africa; 2014. Available from: http://hdl.handle.net/10500/14197

University of South Africa

18. Makelane, Hlamulo Reply. Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes .

Degree: 2010, University of South Africa

URL: http://hdl.handle.net/10500/3838

► Sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline derivatives with stoichiometric amount of terminal alkynes in the presence of bis(triphenylphosphine)palladium(II)chloride and copper iodide in triethylamine afforded the 3-(alkynyl)-2-aryl-4-chloroquinoline, exclusively.… (more)

Subjects/Keywords: 2-aryl-4-chloro-3-iodoquinoline; Sonogashira cross-coupling reaction; Suzuki cross-coupling reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makelane, H. R. (2010). Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes . (Masters Thesis). University of South Africa. Retrieved from http://hdl.handle.net/10500/3838

Chicago Manual of Style (16^th Edition):

Makelane, Hlamulo Reply. “Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes .” 2010. Masters Thesis, University of South Africa. Accessed March 04, 2021. http://hdl.handle.net/10500/3838.

MLA Handbook (7^th Edition):

Makelane, Hlamulo Reply. “Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes .” 2010. Web. 04 Mar 2021.

Vancouver:

Makelane HR. Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes . [Internet] [Masters thesis]. University of South Africa; 2010. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10500/3838.

Council of Science Editors:

Makelane HR. Regioselectivity of palladium-catalyzed sonogashira cross-coupling of 2-aryl-4-chloro-3-iodoquinoline- derivatives with terminal alkynes . [Masters Thesis]. University of South Africa; 2010. Available from: http://hdl.handle.net/10500/3838

Kyoto University / 京都大学

19. Haraguchi, Ryosuke. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究.

Degree: 博士(工学), 2016, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/215552 ; http://dx.doi.org/10.14989/doctor.k19726

新制・課程博士

甲第19726号

工博第4181号

Subjects/Keywords: Bis(iodozincio)methane; Organozinc reagent; Cross-coupling reaction; Asymmetric synthesis; Carbocycle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haraguchi, R. (2016). Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/215552 ; http://dx.doi.org/10.14989/doctor.k19726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haraguchi, Ryosuke. “Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究.” 2016. Thesis, Kyoto University / 京都大学. Accessed March 04, 2021. http://hdl.handle.net/2433/215552 ; http://dx.doi.org/10.14989/doctor.k19726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haraguchi, Ryosuke. “Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究.” 2016. Web. 04 Mar 2021.

Vancouver:

Haraguchi R. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究. [Internet] [Thesis]. Kyoto University / 京都大学; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2433/215552 ; http://dx.doi.org/10.14989/doctor.k19726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haraguchi R. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation : 亜鉛メチル化による官能基化された有機亜鉛反応剤の調製に関する研究. [Thesis]. Kyoto University / 京都大学; 2016. Available from: http://hdl.handle.net/2433/215552 ; http://dx.doi.org/10.14989/doctor.k19726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Da Costa, Laurène. Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections.

Degree: Docteur es, Sciences Chimiques, 2017, Aix Marseille Université

URL: http://www.theses.fr/2017AIXM0350

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Le rhinovirus (RV) est connu pour être l'étiologie de plus de la moitié des rhumes bénins. Ces virus ont également été associés à des pathologies… (more)

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Le rhinovirus (RV) est connu pour être l'étiologie de plus de la moitié des rhumes bénins. Ces virus ont également été associés à des pathologies respiratoires beaucoup plus graves (asthme, bronchopneumopathie chronique obstructive (BPCO) et mucoviscidose). Le développement d'inhibiteurs de décapsidation du virus, appelés agents « capsid-binders », est ainsi devenu une priorité pour de nombreux laboratoires de recherche. Dans ce contexte, une classe d’inhibiteurs se liant au sein de la poche hydrophobe de la protéine capsidaire VP1 a été développée par notre équipe au travers d’une stratégie radicalaire médiée par le TDAE (Tétrakis(DiméthylAmino)Ethylène). Dans le but de poursuivre les investigations sur le hit LPCRW_0005, un travail de pharmacochimie a été entrepris selon deux approches. Dans un premier temps, une optimisation de la taille du LPCRW_0005 a été envisagée par un allongement du squelette chimique. La conception de ces molécules a été guidée par l’utilisation de modélisation moléculaire via la réalisation de docking rigide ligand/protéine. La synthèse de nombreux composés et leur évaluation in vitro, ont permis de mieux apprécier le potentiel biologique de ce type de dérivés. L’identification de la configuration active du centre stéréogène porté par le linker alcool a été rendue possible par la séparation énantiosélective de certains inhibiteurs suivie d’une caractérisation basée sur un protocole de Mosher. Dans un second temps, une étude comparative des séquences primaires protéiques, nous ont conduits à concevoir de nouveaux composés afin de développer des « capsid-binders » à plus large spectre d'action.

Rhinovirus (RV), virus of Picornaviridae family, is known to be the aetiology of more than half of the common cold. Through advances in molecular biology, the rhinoviruses have been associated with much more serious respiratory pathologies (asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis). So, the development of viral attachment and/or uncoating inhibitors named « capsid-binders » molecules has become a priority for many research laboratories. In this context, a class of inhibitors binding into a hydrophobic pocket of the VP1 capsid protein has been identified by our team through a TDAE strategy. In order to follow the investigations on the LPCRW_0005 hit, a pharmacochemistry work was begun according to two approaches. Initially, an optimisation of the LPCRW_0005 size was envisaged by an extension of the scaffold via various pallado-catalyzed cross-coupling reactions. The design of these molecules was guided by the use of molecular modeling via a rigid ligand/protein docking. The synthesis of many compounds and their in vitro biological evaluation on HeLa cells infected with the rhinovirus 14 (RV-B14), refined our knowledge about the biological potential of such a scaffold. The enantioselective separation of some inhibitors followed by a Mosher’s protocol allowed us to identify the active configuration of the alcohol linker. Finally, a comparative study of protein primary…

Advisors/Committee Members: Vanelle, Patrice (thesis director), Terme, Thierry (thesis director).

Subjects/Keywords: Rhinovirus; Capsid-Binder; Réaction par transfert monoélectronique; Tdae; Couplages pallado-Catalysés; Méthode de Mosher; Rhinovirus; Capsid-Binder; Single electron transfer (SET) reaction; Tdae; Pallado-Catalyzed cross-Coupling reactions; Mosher’s method

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Da Costa, L. (2017). Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0350

Chicago Manual of Style (16^th Edition):

Da Costa, Laurène. “Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed March 04, 2021. http://www.theses.fr/2017AIXM0350.

MLA Handbook (7^th Edition):

Da Costa, Laurène. “Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections.” 2017. Web. 04 Mar 2021.

Vancouver:

Da Costa L. Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2017AIXM0350.

Council of Science Editors:

Da Costa L. Pharmacochimie de nouveaux inhibiteurs contre les infections à rhinovirus : Pharmacochemistry of new inhibitors against rhinovirus infections. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0350

Indian Institute of Science

21. Yogesh, S. Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds.

Degree: PhD, Faculty of Science, 2018, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/3698

► The thesis entitled “Design and Development of Metal-Free Cross Dehydrogenative Coupling Reactions for the construction of C-S, C-O and C-C bonds” is divided into three… (more)

▼ The thesis entitled “Design and Development of Metal-Free Cross Dehydrogenative Coupling Reactions for the construction of C-S, C-O and C-C bonds” is divided into three Chapters. Chapter 1 is presented in five parts, which reveals the cross dehydrogenative coupling (CDC) strategies for the C–S bond forming reactions through C–H functionalization strategy using heterocyclic thiols and thiones. Chapter 2 presents tetrabutyl ammonium iodide (TBAI) catalyzed chemoselective α-aminoxylation of ketones with N-hydroxyimidates using TBHP as oxidant under cross dehydrogenative coupling (CDC) strategy. Chapter 3 describes a transition metal-free Minisci reaction for the acylation of isoquinolines, quinolines, and quinoxaline. Chapter 1 Iodine Promoted C-S Bond Forming Reactions using Dimethyl Sulfoxide as an Oxidant Chapter 1 reveals the utility of cross dehydrogenative coupling (CDC) reactions for the formation of C–S bonds by employing C–H functionalization strategies.1 The direct functionalization of C–H bonds to form C–C and C–X (N, O, S and P) bonds using metal-free reaction conditions is an interesting research topic in recent years.2 Use of dimethyl sulfoxide as an oxidant is emerging as one of the research topics of great interest and utility.3 Heterocyclic thiols and thiones are important precursors for synthesizing a variety of pharmaceuticals and biologically active compounds.4 Therefore it is useful to develop CDC reactions using heterocyclic thiols and thiones as precursors. In this chapter, we describe CDC reactions of heterocyclic thiols and thiones for the sulfenylation of ketones, aldehydes, α, β unsaturated methyl ketone derivatives, pyrazolones, enaminones and imidazoheterocycles using DMSO as an oxidant Chapter 1: Part 1 Iodine Promoted Regioselective α-Sulfenylation of Carbonyl Compounds using Dimethyl Sulfoxide as an Oxidant: In this chapter, a rare regioselective C–H sulfenylation of carbonyl compounds with heterocyclic thiones and thiols have been described using iodine and dimethyl sulfoxide as reagents. Thus, dimethyl sulfoxide (as an oxidant) and stoichiometric amount of iodine have been used for the sulfenylation of ketones using heterocyclic thiones. Whereas the sulfenylation of ketones with heterocyclic thiols required catalytic amount of iodine. This protocol offers a rare regioselective sulfenylation of (i) methyl ketones in the presence of more reactive α-CH2 or α-CH groups, and (ii) aldehydes under CDC method. A few representative examples are highlighted in Scheme 1.5 The application of this methodology has been demonstrated by synthesizing a few precursors for Julia-Kocienski olefination intermediates. Scheme 1. Iodine promoted rare regioselective α-sulfenylation of ketones and aldehydes Siddaraj , Y.; Prabhu, K. R. Org. Lett. 2016, 18, 6090 Chapter 1: Part 2 Regioselective Sulfenylation of α’-CH3 or α’-CH2 Groups of α, β Unsaturated Ketones using Dimethyl Sulfoxide as an Oxidant: In this chapter, an interesting regioselective sulfenylation of α’-CH3 or α’-CH2 groups of α, β… Advisors/Committee Members: Prabhu, K R (advisor).

Subjects/Keywords: Cross Dehydrogenative Coupling Reactions; Chemoselective α-Aminoxylation; Acylation Quinolines; Transition Metal Free Minisci Reaction; CDC Reactions; Dimethyl Sulfoxide; Carbonyl Compounds; Ketones; Pyrazolones; Orcanic Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yogesh, S. (2018). Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3698

Chicago Manual of Style (16^th Edition):

Yogesh, S. “Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed March 04, 2021. http://etd.iisc.ac.in/handle/2005/3698.

MLA Handbook (7^th Edition):

Yogesh, S. “Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds.” 2018. Web. 04 Mar 2021.

Vancouver:

Yogesh S. Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Mar 04]. Available from: http://etd.iisc.ac.in/handle/2005/3698.

Council of Science Editors:

Yogesh S. Design and Development of Metal-free Cross Dehydrogenative Coupling Reactions for the Construction of C-S, C-O and C-C bonds. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3698

22. Peramo, Arnaud. Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction.

Degree: Docteur es, Pharmacotechnie et biopharmacie, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLS600

►

Les nanotechnologies ont ouvert de nouvelles perspectives pour l’administration ciblée des médicaments. Les approches actuelles en nanomédecine sont basées sur l’encapsulation d’un principe actif dans… (more)

▼

Les nanotechnologies ont ouvert de nouvelles perspectives pour l’administration ciblée des médicaments. Les approches actuelles en nanomédecine sont basées sur l’encapsulation d’un principe actif dans un nano-vecteur. Nous proposons dans ce travail l’utilisation de nanoparticules non plus pour adresser un médicament encapsulé vers sa cible, mais pour manipuler une protéine d’intérêt en milieu biologique, ce qui constitue une nouvelle stratégie thérapeutique. Avec cet objectif, nous avons identifié une formulation de nanoparticules de palladium, stable, non toxique et dotée d’un pouvoir catalytique remarquable de la réaction de Suzuki-Miyaura. Ce nano-catalyseur permet, en utilisant un dérivé du bore approprié, de greffer des résidus aromatiques sur des acides aminés halogénés dans un tampon phosphate à température et pH physiologiques. En parallèle, la formulation sous forme de nanoparticules de calixarenes fonctionnalisés par des complexes carbéniques du palladium a été également étudiée. Ce nano-réacteur permet d’effectuer dans l’eau et à température ambiante une réaction d’arylation d’amino acides halogénés de manière très efficace. Nous montrons qu’il est possible grâce à ces nanoparticules de modifier sélectivement par une liaison covalente, la thyroglobuline, une protéine naturelle halogénée, impliquée dans la maladie de Basedow et dans certains cancers de la thyroïde. L’absence de modèle cellulaire exprimant la protéine nous a conduit à tester la réaction dans un homogénat d’organe provenant de l’exérèse chirurgicale de la thyroïde chez un patient de la maladie de Basedow. Le couplage de la thyroglobuline par réaction de Suzuki-Miyaura a pu être détecté par analyse protéomique grâce au marquage par un cycle aromatique simple, et par western blot à l’aide d’une sonde biotine autorisant une détection par immuno-essai. En conclusion, la thèse apporte la démonstration de la formation sélective d’une liaison C-C sur une protéine par des nanoparticules de palladium dans un milieu biologique complexe et en conditions physiologiques. Ces résultats pourraient ouvrir la voie à de nouvelles options thérapeutiques permettant de controler le taux de thyroglobuline dans le cas d’une dérégulation hormonale.

Nanotechnology has opened up new perspectives for targeted drug delivery in the treatment of severe diseases. Current approaches in nanomedicine are based on the encapsulation of an active drug in a nanocarrier. In the present study, we have used nanoparticles not to address an encapsulated drug to a target tissue, but for manipulating a protein of interest in a complex biological medium. With this aim, we have identified a stable, non-toxic palladium nanoparticle formulation, embedding a remarkable catalytic activity on the Suzuki-Miyaura reaction. This nano-catalyst allows by using an appropriate boron derivative to couple aromatic residues onto halogenated amino acids in a phosphate buffer at physiological pH. By the same way, the formulation as nanoparticles of calixarene derivatives functionalized with palladium…

Advisors/Committee Members: Couvreur, Patrick (thesis director), Desmaële, Didier (thesis director).

Subjects/Keywords: Palladium nanoparticules; Réaction de Suzuki-Myaura; Chimie in vivo; Thyroglobuline; Protémoque; Palladium nanoparticles; Suzuki-Myaura cross-Coupling reaction; In vivo chemistry; Thyroglobulin; Proteomic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peramo, A. (2019). Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS600

Chicago Manual of Style (16^th Edition):

Peramo, Arnaud. “Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 04, 2021. http://www.theses.fr/2019SACLS600.

MLA Handbook (7^th Edition):

Peramo, Arnaud. “Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction.” 2019. Web. 04 Mar 2021.

Vancouver:

Peramo A. Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2019SACLS600.

Council of Science Editors:

Peramo A. Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée : Selective modification of a protein in biological media by nanocatalyzed Suzuki-Miyaura reaction. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS600

Université de Bordeaux I

23. Pradhan, Anirban. Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés.

Degree: Docteur es, Chimie, 2013, Université de Bordeaux I

URL: http://www.theses.fr/2013BOR14849

►

Les nanorubans de carbone présentent aujourd’hui un grand intérêt en tant que segments de graphène aux propriétés électroniques modulables. Alors que des techniques de synthèse… (more)

▼

Les nanorubans de carbone présentent aujourd’hui un grand intérêt en tant que segments de graphène aux propriétés électroniques modulables. Alors que des techniques de synthèse destructives top down donnent des rubans de très grande taille, d’autres techniques constructives bottom up, par synthèse organique, pourraient former des nanorubans bien définis de géométries contrôlées. Dans cette optique, la réaction de Scholl est un outil chimique précieux car elle permet la graphénisation de longs précurseurs flexibles de type polyphénylène.Etonnamment, des structures distordues peuvent être obtenues majoritairement même si des isomères plans moins encombrés sont a priori favorisés. Nous avons ainsi montré que contre toute attente même un encombrement stérique important n’a aucun effet notoire sur la régiosélectivité et que des composés aromatiques polycycliques courbés sont préférentiellement formés. Ainsi, des structures particulièrement tordues, tel que l’hexabenzotriphénylène (HBTP) peuvent être facilement obtenues à partir de précurseurs de type polyphénylène.Après avoir découvert cette régiosélectivité inattendue, nous en avons tiré parti pour former des composés de type polyhélicène. Plusieurs tentatives de formation de l’hexaphénanthrotriphénylène (HPTP) furent infructueuses à cause de problèmes de réactivité lors des synthèses des précurseurs flexibles correspondants. En mettant au point une stratégie de synthèse versatile fondée sur un précurseur commun, plusieurs substrats flexibles de symétrie C3 ont été synthétisés puis soumis à la réaction de Scholl. Des produits de réarrangement ont cependant été obtenus au détriment des [6]hélicènes attendus. Toutefois, un HBTP fonctionnalisé par des groupements TMS a pu être efficacement préparé, ainsi qu’un hexabenzocoronène (HBC) dont l’exceptionnelle solubilité est due à la distorsion du coeur aromatique sous l’effet des groupements encombrants situés dans les régions baie.Ce fragment [5]hélicène favorisé a enfin été incorporé dans la formulation de nanorubans de carbone tordus, alors composés d’une succession de ce motif. En tant que réactions test, les synthèses du monomère et du dimère correspondants ont été effectuées avec d’excellents rendements et les deux composés entièrement caractérisés. Leurs structures ont été déterminée par diffraction de rayons X sur monocristaux et ont fourni d’intéressantes informations complémentaires quant à leurs configurations. Une stratégie plus générale a enfin été développée et optimisée pour la synthèse systématique d’oligomères plus longs de nanorubans de carbone tordus. En utilisant cette technique les trimère et tétramère correspondants ont été synthétisés et caractérisés par spectrométrie de masse.

Carbon nanoribbons are today of great interest as graphene segments with modulable electronic properties. Whilst top down techniques give giant ribbons, bottom-up organic synthesis may lead to exactly designed nanoribbons of controlled geometries. The Scholl reaction is a precious chemical tool for that purpose since it yields…

Advisors/Committee Members: Durola, Fabien (thesis director), Bock, Harald (thesis director).

Subjects/Keywords: Composés aromatiques polycycliques; Nanorubans de carbone; Hélicènes; Réaction de Scholl; Réactions catalysées de couplages croisés; Polycyclic aromatic compounds (PAC); Carbon nanoribbons; Helicenes; Scholl reaction; Catalyzed cross-coupling reactions

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APA (6^th Edition):

Pradhan, A. (2013). Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés. (Doctoral Dissertation). Université de Bordeaux I. Retrieved from http://www.theses.fr/2013BOR14849

Chicago Manual of Style (16^th Edition):

Pradhan, Anirban. “Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés.” 2013. Doctoral Dissertation, Université de Bordeaux I. Accessed March 04, 2021. http://www.theses.fr/2013BOR14849.

MLA Handbook (7^th Edition):

Pradhan, Anirban. “Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés.” 2013. Web. 04 Mar 2021.

Vancouver:

Pradhan A. Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés. [Internet] [Doctoral dissertation]. Université de Bordeaux I; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013BOR14849.

Council of Science Editors:

Pradhan A. Distorted arenes by Scholl cyclizations, towards twisted carbon nanoribbons : Synthèse de composés aromatiques polycycliques distordus par réaction de Scholl vers des nanorubans de carbone courbés. [Doctoral Dissertation]. Université de Bordeaux I; 2013. Available from: http://www.theses.fr/2013BOR14849

24. XUE FEI. NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS.

Degree: 2015, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/122709

Subjects/Keywords: Nickel catalyst; carbon-carbon formation; cross-coupling; arylmagnesiation; domino reaction; cyclotrimerizatio

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APA (6^th Edition):

FEI, X. (2015). NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/122709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

FEI, XUE. “NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS.” 2015. Thesis, National University of Singapore. Accessed March 04, 2021. http://scholarbank.nus.edu.sg/handle/10635/122709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

FEI, XUE. “NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS.” 2015. Web. 04 Mar 2021.

Vancouver:

FEI X. NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS. [Internet] [Thesis]. National University of Singapore; 2015. [cited 2021 Mar 04]. Available from: http://scholarbank.nus.edu.sg/handle/10635/122709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FEI X. NICKEL-CATALYZED CARBON-CARBON BOND FORMATION REACTIONS. [Thesis]. National University of Singapore; 2015. Available from: http://scholarbank.nus.edu.sg/handle/10635/122709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

25. Rosocha, Yaroslav Gregory S. Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization.

Degree: 2011, University of Toronto

URL: http://hdl.handle.net/1807/32082

PhD Advisors/Committee Members: Batey, Robert A., Chemistry.

Subjects/Keywords: Indene, Thiatriazole, Thiotetrazole, Electrocyclization, Cascade reaction, Isoquinoline, Cross-coupling, HIV inhibitor; 0490

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APA (6^th Edition):

Rosocha, Y. G. S. (2011). Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/32082

Chicago Manual of Style (16^th Edition):

Rosocha, Yaroslav Gregory S. “Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization.” 2011. Doctoral Dissertation, University of Toronto. Accessed March 04, 2021. http://hdl.handle.net/1807/32082.

MLA Handbook (7^th Edition):

Rosocha, Yaroslav Gregory S. “Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization.” 2011. Web. 04 Mar 2021.

Vancouver:

Rosocha YGS. Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization. [Internet] [Doctoral dissertation]. University of Toronto; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1807/32082.

Council of Science Editors:

Rosocha YGS. Development and Investigation of Electrocyclization Reactions Leading Towards Indene and Thiatriazole Formation and their Functionalization. [Doctoral Dissertation]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/32082

Laurentian University

26. Landry, Eric D. Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications.

Degree: 2015, Laurentian University

URL: https://zone.biblio.laurentian.ca/dspace/handle/10219/2420

► The arm-first synthesis of large unimolecular star-structured polyethylene nanoparticles or SPE-NPs (MW > 1,000 kg/mol, PDI ≈ 1.1) joined by a cross-linked polynorbornadiene (PNBD) core… (more)

▼ The arm-first synthesis of large unimolecular star-structured polyethylene nanoparticles or SPE-NPs (MW > 1,000 kg/mol, PDI ≈ 1.1) joined by a cross-linked polynorbornadiene (PNBD) core is described in this thesis. SPE-NPs having high arm number (fn > 100) and tunable arm topologies (hyperbranched HBPE or linear-but-branched LBPE) are conveniently synthesized in a single reactor following four consecutive steps. In step 1, living ethylene polymerization is catalyzed by 0.1 mmol of Pd-diimine catalyst 1 to grow HBPE arms (1 atm C2H4/15 °C) or LBPE arms (27 atm C2H4/5 °C) of tunable lengths (tE = 1-5 h, Mn = 11-40 kg/mol). In step 2, the norbornadiene (NBD) cross-linker is added into the ethylene reactor for several hours (tNBD = 1-4 h) yielding PE-b-PNBD block copolymers with a short PNBD segment bearing cross-linkable pendant double bonds. SPEs are then formed in step 3 during precipitation in acidified methanol (H+/MeOH) and the final SPE-NPs are formed in step 4 after several hours of drying in vacuo at 120 °C. A thorough systematic investigation of the reaction parameters indicates that to produce increasingly larger SPE-NPs, it is essential to add a significant molar excess of NBD to 1 ([NBD]0/[1]0 > 50) and synthesize short LBPE arms but large HBPE arms. When synthesized with LBPE arms, the SPE-NPs have higher MW compared to those synthesized with HBPE arms due to the lower steric hindrance of the linear arms which enables a high number of arms to be joined at the PNBD core. Furthermore, the Pd-diimine catalyst used in the synthesis of the SPE-NPs was encapsulated within the cross-linked PNBD core. These encapsulated Pd(II) species were tested for their activity in hydrogenation reactions of terminal alkenes and alkynes (1-octene, 1-hexene, and 1-hexyne) and Heck coupling reactions of iodobenzene and n-butyl acrylate. Preliminary data suggests that these SPE-NPs may be used as models for the design of more advanced recyclable nanovessel for Pd(II) catalysts.

Subjects/Keywords: star-structured polyethylene nanoparticles; cross-linked polynorbornadiene (PNBD); SPE-NPs; living ethylene polymerization; hydrogenation reactions of terminal alkenes and alkynes; Heck coupling reaction; iodobenzene; n-butyl acrylate

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APA (6^th Edition):

Landry, E. D. (2015). Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications. (Thesis). Laurentian University. Retrieved from https://zone.biblio.laurentian.ca/dspace/handle/10219/2420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Landry, Eric D. “Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications. ” 2015. Thesis, Laurentian University. Accessed March 04, 2021. https://zone.biblio.laurentian.ca/dspace/handle/10219/2420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Landry, Eric D. “Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications. ” 2015. Web. 04 Mar 2021.

Vancouver:

Landry ED. Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications. [Internet] [Thesis]. Laurentian University; 2015. [cited 2021 Mar 04]. Available from: https://zone.biblio.laurentian.ca/dspace/handle/10219/2420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Landry ED. Star-structured polyethylene nanoparticles via Pd-catalyzed living polymerization : synthesis, characterization, and catalytic applications. [Thesis]. Laurentian University; 2015. Available from: https://zone.biblio.laurentian.ca/dspace/handle/10219/2420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Haraguchi, Ryosuke. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation .

Degree: 2016, Kyoto University

URL: http://hdl.handle.net/2433/215552

Subjects/Keywords: Bis(iodozincio)methane; Organozinc reagent; Cross-coupling reaction; Asymmetric synthesis; Carbocycle

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APA (6^th Edition):

Haraguchi, R. (2016). Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/215552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haraguchi, Ryosuke. “Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation .” 2016. Thesis, Kyoto University. Accessed March 04, 2021. http://hdl.handle.net/2433/215552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haraguchi, Ryosuke. “Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation .” 2016. Web. 04 Mar 2021.

Vancouver:

Haraguchi R. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation . [Internet] [Thesis]. Kyoto University; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2433/215552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haraguchi R. Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation . [Thesis]. Kyoto University; 2016. Available from: http://hdl.handle.net/2433/215552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. 山田,重之. Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents.

Degree: Kyoto Institute of Technology / 京都工芸繊維大学

URL: http://hdl.handle.net/10212/1612

►

This thesis consists of five chapters. Chapter 1 describes general introduction including description of fluorinated alkenes as well as brief summary of the results that… (more)

Subjects/Keywords: Organofluorine Compounds; Fluorinated Alkenes; Organometallic Reagents; Addition-elimination Reaction; Fluorine-metal Exchange Reaction; Cross-coupling Reaction

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APA (6^th Edition):

山田,重之. (n.d.). Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents. (Thesis). Kyoto Institute of Technology / 京都工芸繊維大学. Retrieved from http://hdl.handle.net/10212/1612

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

山田,重之. “Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents.” Thesis, Kyoto Institute of Technology / 京都工芸繊維大学. Accessed March 04, 2021. http://hdl.handle.net/10212/1612.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

山田,重之. “Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents.” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.

Vancouver:

山田,重之. Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents. [Internet] [Thesis]. Kyoto Institute of Technology / 京都工芸繊維大学; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10212/1612.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

山田,重之. Studies on the Developments of Selective Synthetic Methods for Polyfluoroalkene Derivatives by Employing Organometallic Reagents. [Thesis]. Kyoto Institute of Technology / 京都工芸繊維大学; Available from: http://hdl.handle.net/10212/1612

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

29. Allouch, Fatima. Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.

Degree: Docteur es, Chimie, 2013, Dijon; Université libanaise

URL: http://www.theses.fr/2013DIJOS002

►

Ce mémoire porte sur l’accès simple et peu coûteux à de nouveaux ligands ferrocéniques aminés et aminophosphinés et leur coordination avec des métaux de transition… (more)

▼

Ce mémoire porte sur l’accès simple et peu coûteux à de nouveaux ligands ferrocéniques aminés et aminophosphinés et leur coordination avec des métaux de transition pour des applications en catalyse homogène.Des métallo-ligands aminés flexibles ont été obtenus et caractérisés après amination réductrice du 1,1’-diformylferrocène. D’autres ligands (N,N) rigides ont été isolés au départ du précurseur du 1,1’-di-tert-butyl-3,3’-diformylferrocène. Des aza-ferrocénophanes ont également été facilement préparés avec ces deux précurseurs carbonylés. Lors de la coordination de ces ligands avec le palladium, un palladacycle original a été isolé et caractérisé par diffraction de rayons X.Des ligands ferrocéniques (N,P) ont été obtenus par trois méthodes: i) ortholithiation de ligands ferrocéniques aminés suivie d’un ajout de chlorophosphine, ii) amination réductrice des ferrocènes formylés substitués ou non en présence d’amine portant une fonction phosphine, iii) substitution directe du ferrocène dilithié par des chlorophosphines comportant un hétérocycle azoté. Leur coordination avec du palladium et du platine a été étudiée. Ces métallo-ligands hybrides ont été impliqués dans des réactions de chlorures d’aryle avec des acides arylboroniques (couplage de Suzuki), ainsi que dans la réaction de Sonogashira avec le couplage de bromures et de chlorures d’aryle avec le phénylacétylène

This thesis focuses on simple and inexpensive access to new amino and aminophosphine ferrocenyl ligands and their coordination with transition metals for applications in homogeneous catalysis.Flexible amine metallo-ligands were obtained and characterized after reductive amination of 1,1'-diformylferrocene. Other rigid (N,N) ligands were isolated starting from the precursor 1,1'-di-tert-butyl-3, 3'-diformylferrocene. Aza-ferrocenophanes were also easily prepared with these two formyl precursors. During the coordination of these ligands with palladium, a stable and original palladacycle was isolated and characterized by DRX.(N,P) ferrocenyl ligands were obtained by three methods: i) ortholithiation of aminoferrocenyl ligands followed by addition of chlorophosphines, ii) reductive amination of substituted or not formylferrocene in the presence of amine bearing a phosphine function, iii) direct substitution of dilithiated ferrocene by chlorophosphines with a nitrogen-containing heterocycle. Their coordination with palladium and platinum has been studied. These hybrid metallo-ligands have been implicated in the reactions of aryl chlorides to arylboronic acids (Suzuki cross-coupling), as well as in the Sonogashira reaction involving of coupling aryl bromides and chlorides to phenylacetylene

Advisors/Committee Members: Pirio, Nadine (thesis director), Naoufal, Daoud (thesis director).

Subjects/Keywords: Métallo-ligands ferrocéniques aminés et aminophosphinés; Palladation; Amination réductrice; Ligands hybrides (N,P); Réaction de couplage carbone-carbone; Suzuki; Sonogashira; Amino and aminophosphine ferrocenyl metallo-ligand; Palladation; Reductive amination; N,P hybrid ligands; C-C cross-coupling reaction; Suzuki; Sonogashira; 541.2; 541.39; 547

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APA (6^th Edition):

Allouch, F. (2013). Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. (Doctoral Dissertation). Dijon; Université libanaise. Retrieved from http://www.theses.fr/2013DIJOS002

Chicago Manual of Style (16^th Edition):

Allouch, Fatima. “Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.” 2013. Doctoral Dissertation, Dijon; Université libanaise. Accessed March 04, 2021. http://www.theses.fr/2013DIJOS002.

MLA Handbook (7^th Edition):

Allouch, Fatima. “Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes.” 2013. Web. 04 Mar 2021.

Vancouver:

Allouch F. Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. [Internet] [Doctoral dissertation]. Dijon; Université libanaise; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013DIJOS002.

Council of Science Editors:

Allouch F. Synthèse et applications de nouveaux complexes métallocéniques multidentes : Synthesis and applications of new multidentate metallocenic complexes. [Doctoral Dissertation]. Dijon; Université libanaise; 2013. Available from: http://www.theses.fr/2013DIJOS002

30. Nakajima, Sho. Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究.

Degree: 博士(工学), 2017, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/225616 ; http://dx.doi.org/10.14989/doctor.k20391

新制・課程博士

甲第20391号

工博第4328号

Subjects/Keywords: Iron catalyst; Cross-coupling reaction; Alkyl halide; X-ray absorption spectroscopy; Mechanistic study; Bisphosphine ligand

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APA (6^th Edition):

Nakajima, S. (2017). Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/225616 ; http://dx.doi.org/10.14989/doctor.k20391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nakajima, Sho. “Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究.” 2017. Thesis, Kyoto University / 京都大学. Accessed March 04, 2021. http://hdl.handle.net/2433/225616 ; http://dx.doi.org/10.14989/doctor.k20391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nakajima, Sho. “Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究.” 2017. Web. 04 Mar 2021.

Vancouver:

Nakajima S. Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究. [Internet] [Thesis]. Kyoto University / 京都大学; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2433/225616 ; http://dx.doi.org/10.14989/doctor.k20391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nakajima S. Mechanistic and Synthetic Studies on Iron-Bisphosphine-Catalyzed Cross-Coupling Reactions of Alkyl Halides : ハロゲン化アルキルを用いる鉄触媒クロスカップリング反応の機構および開発に関する研究. [Thesis]. Kyoto University / 京都大学; 2017. Available from: http://hdl.handle.net/2433/225616 ; http://dx.doi.org/10.14989/doctor.k20391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations