subject:(Crohn s)

1. Mota, Erodilho Sande. Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença.

Degree: Mestrado, Cirurgia do Aparelho Digestivo, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-10032008-153646/ ;

► INTRODUÇÃO: As doenças inflamatórias intestinais têm chamado a atenção da comunidade científica pela multiplicidade de manifestações no trato digestivo, manifestações extra-intestinais e pela sua incidência… (more)

▼ INTRODUÇÃO: As doenças inflamatórias intestinais têm chamado a atenção da comunidade científica pela multiplicidade de manifestações no trato digestivo, manifestações extra-intestinais e pela sua incidência em ascensão. Existe uma grande prevalência de manifestações extra-intestinais em portadores de doença de Crohn e de retocolite ulcerativa, variando na literatura de 24 a 65%. Estas alterações podem surgir antes dos sintomas intestinais, concomitante ou ulteriormente, podendo ou não ter relação com a atividade da doença intestinal. O conhecimento destas manifestações extra-intestinais assim como seu quadro clínico, evolução e tratamento é importante, devido ao aumento da morbidade e mortalidade desencadeada por elas. OBJETIVO: Objetivou-se neste trabalho determinar a prevalência de manifestações extra-intestinais em retocolite ulcerativa e doença de Crohn, correlacionando com diagnóstico do tipo de doença inflamatória intestinal, extensão, tempo de evolução e aparecimento dos sintomas, sexo e atividade da doença. MÉTODOS: Os pacientes que participaram do estudo estão cadastrados no Ambulatório de Doenças Inflamatórias do Serviço de Cirurgia do Cólon, Reto e Ânus do Departamento de Gastroenterologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo de setembro de 1984 até setembro de 2004. Os dados para a pesquisa foram colhidos retrospectivamente de mil protocolos que foram preenchidos em caráter prospectivo na primeira consulta do doente e atualizados em consultas subsequentes. Foram estudadas as manifestações articulares, dermatológicas, oftalmológicas, urológicas, hepáticas, pulmonares e vasculares. RESULTADOS: Entre os 1.000 pacientes estudados encontrou-se 468 com doença de Crohn (46,8%) e 532 com retocolite ulcerativa (53,2%). Foram encontrados 627 pacientes com pelo menos uma forma de manifestação extra-intestinal(315-59,2% com RCUI e 312-66,7% com doença de Crohn). A média de tempo de duração da doença inflamatória intestinal dos pacientes que tinham manifestações extra-intestinais foi de 10,23 anos, comparado a 7,89 anos daqueles que não possuíam, sendo estatisticamente significativo. Também foi evidenciado que as manifestações extraintestinais surgiram com maior frequencia ulteriormente aos sintomas intestinais da doença. CONCLUSÕES: Na retocolite ulcerativa a maior extensão da doença no cólon foi proporcional a incidência de manifestações extra-intestinais, enquanto na doença de Crohn, quando havia algum acometimento colônico era maior a incidência destas manifestações. Apenas as manifestações urológicas tiveram uma predisposição maior pela doença de Crohn, e nestes, no sexo masculino. As manifestações articulares e dermatológicas foram mais prevalentes no sexo feminino tanto em retocolite ulcerativa quanto na doença de Crohn. Na doença de Crohn também houve maior prevalência de manifestações hepáticas no sexo feminino. As manifestações articulares, dermatológicas e vasculares tiveram uma maior correlação com a atividade da doença intestinal em ambos os… Advisors/Committee Members: Kiss, Desiderio Roberto.

Subjects/Keywords: Crohn\'s disease; Doença de Crohn; Enteropatias inflamatórias; Inflammatory enteropathy; Prevalence; Prevalência; Proctocolite; Proctocolitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mota, E. S. (2008). Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5154/tde-10032008-153646/ ;

Chicago Manual of Style (16^th Edition):

Mota, Erodilho Sande. “Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença.” 2008. Masters Thesis, University of São Paulo. Accessed March 09, 2021. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-10032008-153646/ ;.

MLA Handbook (7^th Edition):

Mota, Erodilho Sande. “Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença.” 2008. Web. 09 Mar 2021.

Vancouver:

Mota ES. Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 09]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-10032008-153646/ ;.

Council of Science Editors:

Mota ES. Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/5/5154/tde-10032008-153646/ ;

2. A.M. Maestroni. DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE.

Degree: 2019, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/621110

► Riassunto Introduzione. Numerosi fattori, tra cui eventi immunitari, agenti ambientali tossici, predisposizione genetica e microbiota anormale svolgono un ruolo chiave nella patogenesi della malattia di… (more)

▼ Riassunto Introduzione. Numerosi fattori, tra cui eventi immunitari, agenti ambientali tossici, predisposizione genetica e microbiota anormale svolgono un ruolo chiave nella patogenesi della malattia di Crohn, ma il principale meccanismo alla base è ancora oggetto di studio. L'omeostasi della mucosa intestinale si basa su un delicato equilibrio tra auto-rinnovamento e differenziazione, che è garantita dal ricambio delle cellule staminali intestinali all'interno delle cripte. Recenti studi suggeriscono che una differenziazione alterata delle cellule staminali intestinali (ISC) può facilitare l'insorgenza della malattia di Crohn attraverso la formazione di una barriera antimicrobica difettosa, che consente ai batteri intestinali di provocare l'infiammazione. Lo scopo del nostro studio è quello di esplorare se le ISC sono danneggiate e le loro proprietà rigenerative sono alterate nella malattia di Crohn, rappresentando così un nuovo attore nell'insorgenza della malattia e un potenziale bersaglio terapeutico per ripristinare le capacità di auto-rinnovamento della mucosa intestinale. Metodi. Su campioni intestinali (sia area marginale che infiammata rispetto alla sede della malattia) ottenuti da pazienti con e senza malattia di Crohn è stata condotta un’analisi del trascrittoma per valutare l'espressione dei marcatori per ISC. Le proprietà rigenerative delle ISC sono state studiate utilizzando il test del mini-guts, in cui le cripte purificate sono state coltivate come organoidi tridimensionali e la loro morfologia / sviluppo sono stati valutati. Infine, mini-guts sono stati coltivati a partire dalle cripte di soggetti sani con siero di pazienti affetti da malattia di Crohn per dimostrare se i fattori circolanti / citochine potessero esercitare un effetto significativo nell'abrogazione dello sviluppo di organoidi e influenzare l'espressione dei marcatori per ISC. Risultati. I marcatori per ISC, in particolare LGR5 e EPHB2, sono scarsamente espressi in cripte isolate da campioni intestinali di pazienti con malattia di Crohn. È interessante notare che i marcatori per ISC sono più preservati nella zona sana, mentre la loro espressione è quasi assente nell'area infiammata. Ancora più importante, la capacità delle ISC di auto-rinnovamento testata nel saggio mini-guts, è stata trovata significativamente ridotta nei pazienti con malattia di Crohn, con solo il 40% dei mini-guts che si sviluppano da cripte ottenute dall'area marginale e meno del 5% da quelle isolate dalla parte infiammata del campione intestinale. Quando i mini-guts ottenuti dalle cripte dei controlli sono stati coltivati in presenza di siero di pazienti affetti da malattia di Crohn non riuscivano a generare organoidi normali e mostravano una ridotta espressione dei marcatori per ISC EPHB2 e LGR5. Conclusione. Abbiamo dimostrato che il pool delle ISC è ridotto nella malattia di Crohn e che questo si associa a una perdita di proprietà rigenerative delle ISC all'interno delle cripte. La crescita di mini-gut in vitro in presenza del siero di pazienti affetti da morbo… Advisors/Committee Members: TUTOR: G. ZUCCOTTI, COORDINATOR: L. PINOTTI, ZUCCOTTI, GIAN VINCENZO, PINOTTI, LUCIANO.

Subjects/Keywords: INTESTINAL STEM CELL; Crohn' s disease; Settore MED/12 - Gastroenterologia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maestroni, A. (2019). DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/621110

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maestroni, A.M.. “DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE.” 2019. Thesis, Università degli Studi di Milano. Accessed March 09, 2021. http://hdl.handle.net/2434/621110.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maestroni, A.M.. “DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE.” 2019. Web. 09 Mar 2021.

Vancouver:

Maestroni A. DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE. [Internet] [Thesis]. Università degli Studi di Milano; 2019. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2434/621110.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maestroni A. DYSREGULATION OF INTESTINAL STEM CELLS IN CROHN'S DISEASE. [Thesis]. Università degli Studi di Milano; 2019. Available from: http://hdl.handle.net/2434/621110

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Montana

3. Benson, Jenna Marie. Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease.

Degree: PhD, 2012, University of Montana

URL: https://scholarworks.umt.edu/etd/234

► Activation of the aryl hydrocarbon (AhR), a ligand-activated transcription factor present in many immune cells, can trigger immunosuppressive responses through the generation of regulatory cells.… (more)

▼ Activation of the aryl hydrocarbon (AhR), a ligand-activated transcription factor present in many immune cells, can trigger immunosuppressive responses through the generation of regulatory cells. Several AhR ligands exist in the diet including environmental contaminants, such as its prototypical ligand 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD), and natural sources, such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in mucosal immune responses is not well understood to date so we aimed to understand the consequences of AhR activation in gut inflammatory responses. The overall hypothesis of this project is that AhR agonists found in the diet have the potential to dampen inflammation associated with Crohn's disease. The first goal of this project was to examine the role of AhR activation in the development and progression of colitis using TCDD and the natural ligand I3C. TCDD suppressed TNBS-induced colitis, as demonstrated by the decreased disease severity and dampened inflammation in the gut. TCDD-treated mice exhibited decreased inflammatory mediator production and increased frequency of regulatory cells, both Foxp3+ Tregs and dendritic cells (DCs) in gut immune tissues. In comparison, I3C suppressed disease severity in females but not males. Sex-specific effects on colonic cytokine production and gene expression were observed. The second goal of this project was to define the cellular mechanisms by which AhR ligands elicit their effects on important immune cell populations present in the gut. Therefore, we investigated the immunomodulatory effects of the dietary AhR ligands I3C and indirubin in bone marrow derived DCs (BMDCs). I3C-and indirubin-treated BMDCs upregulated the expression of immunoregulatory genes, such as ALDH1A, IDO, and TGFâ, and also drove the generation of Foxp3+ Tregs. Following LPS stimulation, I3C-and IO-treated BMDCs suppressed the LPS-induced production of TNF-á, IL-1â, IL-6 and IL-12. Anti-inflammatory effects were also observed in intestinal epithelial cells (IECs) treated with AhR ligands. Thus, I3C and indirubin possess immunosuppressive and anti-inflammatory effects in BMDCs and IECs. Taken together, our data demonstrate that the AhR is a therapeutic target that warrants further investigation, as natural AhR ligands may effectively prevent the onset of chronic inflammatory diseases or more effectively induce and maintain remission when combined with conventional medicine.

Subjects/Keywords: Aryl Hydrocarbon Receptor; Crohn'; s Disease; Indirubin; Indole-3-Carbinol; Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Benson, J. M. (2012). Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease. (Doctoral Dissertation). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/234

Chicago Manual of Style (16^th Edition):

Benson, Jenna Marie. “Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease.” 2012. Doctoral Dissertation, University of Montana. Accessed March 09, 2021. https://scholarworks.umt.edu/etd/234.

MLA Handbook (7^th Edition):

Benson, Jenna Marie. “Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease.” 2012. Web. 09 Mar 2021.

Vancouver:

Benson JM. Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease. [Internet] [Doctoral dissertation]. University of Montana; 2012. [cited 2021 Mar 09]. Available from: https://scholarworks.umt.edu/etd/234.

Council of Science Editors:

Benson JM. Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease. [Doctoral Dissertation]. University of Montana; 2012. Available from: https://scholarworks.umt.edu/etd/234

4. Costa, Camila Ortiz Prospero Cavalcante. Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn.

Degree: Mestrado, Gastroenterologia Clínica, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-12012012-160215/ ;

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Introdução: Aproximadamente 25 a 30% dos pacientes com DC iniciam a doença antes da idade dos 20 anos. O déficit de crescimento é a complicação… (more)

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Introdução: Aproximadamente 25 a 30% dos pacientes com DC iniciam a doença antes da idade dos 20 anos. O déficit de crescimento é a complicação mais específica da DII pediátrica, causada pela combinação de ingestão calórica inadequada, aumento das perdas calóricas e inflamação ativa persistente da mucosa intestinal. Pacientes com DII comumente sofrem de desnutrição protéico-energética no diagnóstico e com flutuações durante todo o curso da doença. A perda de peso é uma característica comum no paciente com DII recém diagnosticada, particularmente na DC, e acompanha quase todas as recaídas. Aproximadamente 60% das crianças com DC apresentam perda de peso recente no momento do diagnóstico. Objetivos: verificar o estado nutricional de pacientes portadores de DC na adolescência, através da avaliação da composição corporal, dosagem de macro e micronutrientes e consumo alimentar. Casuística e Métodos: vinte e dois pacientes com DC em atividade (leve ou moderada), vinte e nove com DC em remissão e 35 parentes de 1º grau desses pacientes de mesma faixa etária (grupo controle) foram selecionados para participar prospectivamente. Antropometria (peso, estatura e índice de massa corporal (IMC) expressos em z escore, bioimpedância e estágio de Tanner), níveis séricos e a ingestão de macro e micronutrientes foram avaliados. Resultados: os adolescentes com DC em atividade seguidos pelo DC em remissão tiveram menor valor de escore z da estatura/idade e IMC para a idade, da massa magra e do estágio pubertário (p<0,05) do que o grupo controle. Os pacientes com DC apresentaram alterações significativas da qualidade da ingestão alimentar, principalmente calorias, proteínas, fibras e micronutrientes, refletindo nas dosagens séricas principalmente das vitaminas A e E (p<0,05). Conclusão: Adolescentes com DC, mesmo quando na fase de atividade da doença leve e inativa, apresentam riscos nutricionais, reforçando a importância da avaliação nutricional

Introduction: About 25 to 30% of patients with Crohns disease begin before age 20 years. The growth deficit is the most specific complication of pediatric CD, caused by a combination of inadequate energy intake, increased loss of calories and persistent active inflammation of the mucosa intestinal. Patients with IBD often suffer from protein-energy malnutrition in the diagnosis and fluctuations throughout the course of the disease. Weight loss is a common feature in patients with newly diagnosed IBD, particularly in CD, and accompanies almost all relapses. Approximately 60% of children with CD have a recent weight loss at diagnosis Objectives: We aimed to determine the nutritional status of patients with CD in adolescence, through the assessment of body composition, levels of macro and micronutrients and food consumption. Methods: Twenty-two patients with CD activity (mild or moderate), twenty-nine with CD in remission and 35 relatives of a degree of these patients the same age range (control group) were selected to enrolled prospectively . Anthropometry (weight, height and body mass index…

Advisors/Committee Members: Carrilho, Flair José.

Subjects/Keywords: Adolescent; Adolescente; Avaliação nutricional; Consumo alimentar; Crohn\'s disease; Doença de Crohn; Food consumption; Nutritional assessment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, C. O. P. C. (2011). Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5147/tde-12012012-160215/ ;

Chicago Manual of Style (16^th Edition):

Costa, Camila Ortiz Prospero Cavalcante. “Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn.” 2011. Masters Thesis, University of São Paulo. Accessed March 09, 2021. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-12012012-160215/ ;.

MLA Handbook (7^th Edition):

Costa, Camila Ortiz Prospero Cavalcante. “Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn.” 2011. Web. 09 Mar 2021.

Vancouver:

Costa COPC. Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Mar 09]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-12012012-160215/ ;.

Council of Science Editors:

Costa COPC. Avaliação clínico-laboratorial do estado nutricional de adolescentes portadores de doença de Crohn. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5147/tde-12012012-160215/ ;

5. André Luis Tavares Pinto. Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta.

Degree: 2010, Universidade Federal de Juiz de Fora

URL: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=736

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The Crohns disease is a chronic, inflammatory, multisystem bowel disorder with a relapsing course. Her etiology remains unknown but probably theres a scenario characterized by… (more)

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The Crohns disease is a chronic, inflammatory, multisystem bowel disorder with a relapsing course. Her etiology remains unknown but probably theres a scenario characterized by inibition of innate immunity and exacerbation of the adaptative immunity with exacerbated mucosal inflammatory activity. Then, the corticosteroids have been the mainstay of pharmacologic treatment for inducing clinical remission in the disease. However, the prohibitive side effects of prolonged corticosteroid therapy associated with high frequency of the corticosteroid- dependency in the disease taken to alternative treatments for long- term maintenance of clinical remission. The immunomodulators, especially, the purine analogs, azathioprine(AZA) or 6- mercaptopurine are the major option for this indication, with corticosteroid- sparing proprieties. The use of these agents is supported by randomized, controlled clinical studies. However, these trials have not evaluated the specific issue of the steroid dependence. Thus, our objectives in this study were to asses the efficacy and safety of AZA therapy in patients strictly with steroid-dependent Crohn`s disease and possibly, factors associated with sustained clinical remission. Therefore, 106 adults patients with steroid-dependent Crohn`s disease were prospectively included for treatment with AZA (2-3mg/Kg/day) during the period of follow up as long as 10 years. The proportion of patients remaining in sustained steroid-free remission at 12, 24, 36, 48 and 60 months was 0.61, 0.73, 0.72, 0.70 and 0.70, respectively. Thereafter, the annual rate of weaning from steroids decreased gradually, reaching a nadir of 0.41 at 108 months. Median time to complete steroid withdrawal was 6 months. Demographics, disease-related data and the AZA dose did not correlate with sustained remission. Only the reduced mean leukocyte count during the follow up was associated with remission free steroids (P= 0.01). Serious adverse effects related to AZA therapy were uncommon

A doença de Crohn é uma afecção intestinal inflamatória crônica, multissistêmica e de caráter recorrente. Sua etiopatogênese permanece ainda desconhecida, mas considera-se haver um cenário fisiopatológico caracterizado, principalmente, pela inibição da imunidade inata com exacerbação da imunidade adaptativa, com atividade inflamatória mucosa intensificada. Por isso, os corticosteróides constituem a base fundamental do tratamento farmacológico na indução da remissão clínica na doença, graças às suas potentes ações como supressores do processo inflamatório. Entretanto, os proibitivos efeitos colaterais da corticoterapia prolongada associados à alta freqüência da cortico-dependencia na doença estimulou a busca de alternativas terapêuticas para manutenção da remissão no longo prazo. Nesse contexto, os imunossupressores, particularmente, os análogos da purina, azatioprina (AZA) ou 6-mercaptopurina ocupam um papel central no tratamento de manutenção na doença, com efeitos poupadores de esteróides. A utilização desses agentes para manter a remissão clínica…

Advisors/Committee Members: Luiz Carlos Bertges, Paulo Sérgio Gonçalves da Costa, Herval de Lacerda Bonfante, Fábio Heleno de Lima Pace, Júlio Maria Fonseca Chebli.

Subjects/Keywords: Crohn`s disease; Corticosteróides; Azatioprina; Doença Inflamatória Intestinal; Doença de Crohn; Inflammatory Bowel Disease; Azathioprine; Corticosteroids; MEDICINA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pinto, A. L. T. (2010). Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta. (Thesis). Universidade Federal de Juiz de Fora. Retrieved from http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinto, André Luis Tavares. “Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta.” 2010. Thesis, Universidade Federal de Juiz de Fora. Accessed March 09, 2021. http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinto, André Luis Tavares. “Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta.” 2010. Web. 09 Mar 2021.

Vancouver:

Pinto ALT. Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta. [Internet] [Thesis]. Universidade Federal de Juiz de Fora; 2010. [cited 2021 Mar 09]. Available from: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinto ALT. Azatioprina no tratamento de pacientes com doença de Crohn córtico-dependente: resultados no longo prazo e fatores preditivos de resposta. [Thesis]. Universidade Federal de Juiz de Fora; 2010. Available from: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Millan, Isabel Cristina Da Silva. Manifestações orais da doença de Crohn.

Degree: 2017, Universidade Fernando Pessoa

URL: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6312

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A doença de Crohn (DC) é uma doença crónica de etiologia complexa, envolvendo fatores ambientais, genéticos e imunológicos. A DC apresenta um quadro clínico complexo… (more)

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A doença de Crohn (DC) é uma doença crónica de etiologia complexa, envolvendo fatores ambientais, genéticos e imunológicos. A DC apresenta um quadro clínico complexo que inclui alterações intestinais e extra-intestinais e, entre estas últimas, estão as manifestações orais que são classificados em lesões específicas e não específicas. Estas lesões são variadas incluindo úlceras, hiperplasia gengival, aftas, entre outras e afetam essencialmente a mucosa, gengiva, lábios, área vestibular e retromolar. As lesões orais podem não ser derivadas da própria patologia mas, também, do uso prolongado de fármacos por estes pacientes e pela sua deficiente absorção de nutrientes. Por estas razões, o paciente com DC necessita de uma atenção própria do médico dentista, especialmente durante os períodos de exacerbação da doença. A terapia farmacológica da DC inclui imunossupressores, corticosteróides, e aminossalicilatos, que são utilizados para o controlo dos sintomas intestinais, o que, regra geral, é também suficiente para o tratamento das manifestações orais.

Crohn's disease (CD) is a chronic disease of complex etiology, involving environmental, genetic and immunological factors. CD presents a complex clinical picture that includes intestinal and extra-intestinal manifestations, and these last ones include oral manifestations that are classified into specific and non-specific lesions. The oral lesions are several including ulcers, gingival hyperplasia, aphtha’s, between others affecting mainly the mucosa, gingiva, lips, vestibular and retromolar areas. Other oral lesions are those caused by the prolonged use of drugs by this patients and nutrients malabsorption. For these reasons the patient with CD needs more attention from the medical dentist, especially during periods of exacerbation of the disease. Pharmacological therapy of Crohn Disease includes immunosuppressant’s, corticosteroids and aminosalicylates, which are used to control intestinal symptoms and also are generally sufficient for the treatment of oral manifestations.

Advisors/Committee Members: Soares, Sandra.

Subjects/Keywords: Doença de Crohn; Doença Inflamatória Intestinal; Granulomatose Orofacial; Lesões Orais e Doença Crónica; Terapêutica na Doença de Crohn; Crohn`s Disease; Inflammatory Bowel Disease; Orofacial Granulomatosis; Oral Lesions and Chronic Disease; Therapeutic in Crohn`s Disease; Domínio/Área Científica::Ciências Médicas::Medicina Clínica

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APA (6^th Edition):

Millan, I. C. D. S. (2017). Manifestações orais da doença de Crohn. (Thesis). Universidade Fernando Pessoa. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Millan, Isabel Cristina Da Silva. “Manifestações orais da doença de Crohn.” 2017. Thesis, Universidade Fernando Pessoa. Accessed March 09, 2021. https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Millan, Isabel Cristina Da Silva. “Manifestações orais da doença de Crohn.” 2017. Web. 09 Mar 2021.

Vancouver:

Millan ICDS. Manifestações orais da doença de Crohn. [Internet] [Thesis]. Universidade Fernando Pessoa; 2017. [cited 2021 Mar 09]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Millan ICDS. Manifestações orais da doença de Crohn. [Thesis]. Universidade Fernando Pessoa; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

7. Lehtinen, Pieta. Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes .

Degree: 2016, Tampere University

URL: https://trepo.tuni.fi/handle/10024/99128

► Kroonisten tulehduksellisten suolistosairauksien (IBD) kaksi pääryhmää ovat haavainen paksusuolen tulehdus (UC) ja Crohnin tauti (CD). Haavaisen paksusuolen tulehduksen yleisin oire on veriripuli. Vastaavasti Crohnin taudin… (more)

▼ Kroonisten tulehduksellisten suolistosairauksien (IBD) kaksi pääryhmää ovat haavainen paksusuolen tulehdus (UC) ja Crohnin tauti (CD). Haavaisen paksusuolen tulehduksen yleisin oire on veriripuli. Vastaavasti Crohnin taudin tyyppioireita ovat vatsakipu ja ripuli. Nämä etiologialtaan tuntemattomat suoliston krooniset tulehdussairaudet ovat lisääntyneet viimeisten vuosikymmenten aikana etenkin länsimaissa. Geneettisen alttiuden lisäksi sairauden puhkeamiseen vaikuttavat esimerkiksi ympäristötekijät. Etenkin lapsilla kroonisiin tulehduksellisiin suolistosairauksiin sairastuminen voi vaikuttaa laajalti kehitykseen aina pituuskasvusta elämänlaatuun. Tämän väitöskirjatutkimuksen tavoitteena oli selvittää lasten IBD:n ilmaantuvuus Suomessa vuosien 1987 ja 2003 välillä. Tavoitteena oli lisäksi tutkia ympäristötekijöiden vaikutusta ilmaantuvuuden alueellisiin eroihin. Lasten kroonisten suolistosairauksien taudinkuvaa, käytettyjä hoitomuotoja ja sairauden vaikutusta elämänlaatuun selvitettiin sairauskertomusten ja kyselytutkimuksen perusteella. Tulehduksellisten suolistosairauksien ilmaantuvuus kolminkertaistui suomalaisen lapsiväestön keskuudessa tutkimusjakson aikana. Alueilla, joissa on matala lapsiväestöntiheys, havaittiin suuremmat ilmaantuvuusluvut verrattuna alueisiin, joissa lapsiväestöntiheys on korkea. Maanviljelijöiden määrällä, merenrannan läheisyydellä, paperitehtaiden sijainnilla tai vesijohtoveden kemikaalipitoisuuksilla ei todettu olevan merkittävää vaikusta ilmaantuvuuden alueellisiin eroihin. Lapsilla taudinkuva on usein aggressiivinen; jopa joka viides lapsipotilas joutui leikkaukseen. Elämänlaadun havaittiin olevan alentunut varhaisaikuisuudessa verrattuna terveisiin ikätovereihin. Tulevaisuudessa onkin tärkeää selvittää lasten tulehduksellisten suolistosairauksien ilmaantuvuuden nopean kasvun taustalla olevia tekijöitä.; Background: The incidence of inflammatory bowel disease (IBD) has been increasing among children especially in Western countries over the past decades. Crohn’s disease (CD) predominates over ulcerative colitis (UC) in most countries. The factors behind this increase are mainly unknown. Environmental factors influence, however, unquestionably the pathogenesis of IBD. The disease course in pediatric IBD is suggested to be more severe compared to adults which may have particularly impact on child development. The possible long-term sequelae of pediatric onset disease include growth impairment, risk of surgery and reduced quality of life. Objectives: This epidemiological study aimed to evaluate the incidence of IBD among Finnish children between the years 1987-2003. The role of environmental determinants (pediatric population density, agricultural industry, paper mills or sea shore close to the place of residence, north-south gradient and chemical concentrations of tap water) in the spatial variations of pediatric IBD was explored. Further, medical record data were applied in the characterization of the clinical picture. The long-term outcome of pediatric IBD patients was…

Subjects/Keywords: IBD ; Crohnin tauti ; haavainen paksusuolen tulehdus ; ilmaantuvuus ; Crohn´s disease ; ulcerative colitis ; incidence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lehtinen, P. (2016). Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/99128

Chicago Manual of Style (16^th Edition):

Lehtinen, Pieta. “Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes .” 2016. Doctoral Dissertation, Tampere University. Accessed March 09, 2021. https://trepo.tuni.fi/handle/10024/99128.

MLA Handbook (7^th Edition):

Lehtinen, Pieta. “Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes .” 2016. Web. 09 Mar 2021.

Vancouver:

Lehtinen P. Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes . [Internet] [Doctoral dissertation]. Tampere University; 2016. [cited 2021 Mar 09]. Available from: https://trepo.tuni.fi/handle/10024/99128.

Council of Science Editors:

Lehtinen P. Pediatric Inflammatory Bowel Disease in Finland: Incidence and Long-term Outcomes . [Doctoral Dissertation]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/99128

Freie Universität Berlin

8. Reichhardt, Adriane. Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9802

► Morbus Crohn is an inflammatory bowel disease (IBD). The disease is a result of genetic disposition, immunologic disorders and environmental influences as much as differences… (more)

▼ Morbus Crohn is an inflammatory bowel disease (IBD). The disease is a result of genetic disposition, immunologic disorders and environmental influences as much as differences of the intestinal mucosa. On the immunologic site, there is an imbalance between immunologic response and tolerance against the microbiom. Regulatory t cells play an essential role sustaining the immunologic balance. For IBD, current data show that Treg proportion in peripheral blood is decreased in active disease. So far, no functional defects of Treg from IBD patients have been described since they maintain their normal function of cell-contact-dependent, cytokine-independent suppressive capacity, even against pathogenic T-effector cells derived from the inflamed mucosa. In contrast to peripheral Treg, their frequency is comparatively low in inflamed IBD mucosa compared to diverticulitis. Currently, it is not clear whether this phenomenon is caused by a disturbed peripheral induction or migration of Treg. Here, we demonstrate that Treg from CD patients show a functional defect caused by an impaired CCR4-dependent migration capacity and mediated by a decreased expression of CCR4. This may explain decreased Treg frequencies in inflamed IBD mucosa. It is probable that CCR4 is not the only molecule that is involved in the inappropriate migration of Treg in CD. It has been described in CD that fewer CD4+ memory cells express CD62L. This receptor decelerates lymphocytes by engaging ligands expressed on high endothelial venules. CD62L is therefore required for recirculation and compartmentalization of CD4+ cells between blood and lymph nodes. Although we found an accumulation of Treg in mesenteric lymph nodes, there is also a lower percentage of CD62L+ peripheral Treg, some of them also express CCR4. This may point to a more extensively disturbed migration of Treg in CD. Based on these results, it becomes conceivable to design therapeutic strategies which manipulate the intestinal recruitment of Treg and thus suppress the pathologically increased immune reaction in IBD. Advisors/Committee Members: w (gender), Prof. Dr. med. M. Zeitz (firstReferee), Prof. Dr. rer. nat. A. Thiel, Prof. Dr. med. A. Stallmach (furtherReferee).

Subjects/Keywords: regulatory t cells; crohn´s disease; CCR4; migration; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Reichhardt, A. (2013). Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reichhardt, Adriane. “Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease.” 2013. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-9802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reichhardt, Adriane. “Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease.” 2013. Web. 09 Mar 2021.

Vancouver:

Reichhardt A. Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-9802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reichhardt A. Impaired CCR4-dependent migration of regulatory T cells in Crohn´s disease. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-9802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jönköping University

9. Wåhlin, Monica. Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie.

Degree: Dep. of Nursing Science, 2015, Jönköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27404

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Bakgrund: En kronisk oförutsägbar sjukdom som Crohns sjukdom framkallar fysisk, psykologisk och social stress. Sjukdomen påverkar vardagen, försämrar livskvalitet och skapar oro. För att… (more)

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Bakgrund: En kronisk oförutsägbar sjukdom som Crohns sjukdom framkallar fysisk, psykologisk och social stress. Sjukdomen påverkar vardagen, försämrar livskvalitet och skapar oro. För att bedriva personcentrerad vård krävs insikt i hur denna oro upplevs. Syfte: Syftet med studien var att belysa sjukdomsrelaterad oro hos personer med Crohns sjukdom. Metod: Åtta kvinnor och fyra män mellan 30 och 64 år som skattat sin sjukdomsrelaterade oro som hög eller mycket hög identifierades. Intervjuer genomfördes och analyserades med kvalitativ innehållsanalys. Resultat: Analysen genererade tre kategorier: (1) Oro för sjukdomen i sig, (2) känslor runt oron, (3) samt hantering av oron. Sjukdomens oförutsägbarhet samt nedsatt funktion till följd av trötthet och bristande kontroll över tarmfunktionen var de mest framträdande orsakerna till oro. Oron skapade känslor av stress, skuld och besvikelse. Deltagarna uttryckte önskemål att få prata om och synliggöra oron men hade också funnit egna sätt att hantera denna. Slutsats: Det finns ett kvarstående behov av att ventilera och få förståelse för sjukdomsrelaterad oro, även efter många års sjukdom. Personer med Crohns sjukdom måste få prata om sin oro, vara en aktiv partner i vården och tillsammans med vårdgivaren finna sätt att hantera oron så att denna kan lindras.

Background: A chronic, unpredictable disease as Crohn's disease provides physical, psychological and social stress. The disease affects everyday life, impairs quality of life and create worries. To conduct person-centered care requires insight into how this worry is experienced. Objective: To explore disease-related worries in persons with Crohn´s disease. Method: Eight women and four men between 30 and 64 who estimated their disease-related worries high or very high were identified. Interviews were conducted and analyzed with content analysis. Results: The analysis generated three categories: (1) Worries about the disease itself, (2) feelings around the worries, (3) management of the worries. The unpredictable course of the disease and the impaired function due to fatigue and lack of control of bowel function were the most prominent causes of worries. The worries created feelings of stress, guilt and disappointment. The participants expressed the wish to talk about and make the worries visible but had also found their own ways to handle it. Conclusion: There is a persistent need to vent and get an understanding of disease-related worries, even after many years of disease. Persons with Crohn's disease need to talk about their worries, be an active partner in healthcare and together with the health-care providers find ways to handle the worries so it can be relieved.

Subjects/Keywords: Crohn´s disease; inflammatory bowel disease; patient-centered care; qualitative research; worries; Crohns sjukdom; inflammatorisk tarmsjukdom; kvalitativ forskning; oro; patientcentrerad vård

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wåhlin, M. (2015). Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie. (Thesis). Jönköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wåhlin, Monica. “Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie.” 2015. Thesis, Jönköping University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wåhlin, Monica. “Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie.” 2015. Web. 09 Mar 2021.

Vancouver:

Wåhlin M. Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie. [Internet] [Thesis]. Jönköping University; 2015. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wåhlin M. Sjukdomsrelaterad oro hos personer med Crohns sjukdom- en intervjustudie. [Thesis]. Jönköping University; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-27404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Linnaeus University

10. Gustafsson, Susanne. Fysisk Aktivitet hos Barn och Ungdomar med IBD.

Degree: Health and Caring Sciences, 2020, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-91238

► Background Pediatric IBD can limit the dayly life and is associated with psychosocial strain and future illness. However, physical activity and exercise are at… (more)

Subjects/Keywords: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn´s Disease; Children; Adolescents; Physical activity; Exercise; Health; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gustafsson, S. (2020). Fysisk Aktivitet hos Barn och Ungdomar med IBD. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-91238

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gustafsson, Susanne. “Fysisk Aktivitet hos Barn och Ungdomar med IBD.” 2020. Thesis, Linnaeus University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-91238.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gustafsson, Susanne. “Fysisk Aktivitet hos Barn och Ungdomar med IBD.” 2020. Web. 09 Mar 2021.

Vancouver:

Gustafsson S. Fysisk Aktivitet hos Barn och Ungdomar med IBD. [Internet] [Thesis]. Linnaeus University; 2020. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-91238.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gustafsson S. Fysisk Aktivitet hos Barn och Ungdomar med IBD. [Thesis]. Linnaeus University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-91238

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. ELMAGHRAWY, KHALID MUFTAH. Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling.

Degree: School of Dental Sciences. Discipline of Dental Science, 2019, Trinity College Dublin

URL: http://hdl.handle.net/2262/88800

► Abstract Aims: This study aimed to analyse the oral mucosal microbiota (bacteria and fungi) in paediatric IBD patients. The mucosa was selected rather than the… (more)

▼ Abstract Aims: This study aimed to analyse the oral mucosal microbiota (bacteria and fungi) in paediatric IBD patients. The mucosa was selected rather than the saliva as this is the region where tissue and immune cells directly interact with the microbiome Methods: The oral microbiome and mycobiome were examined in a cohort of children diagnosed with Crohn s disease (n=38, CD), and ulcerative colitis (n=21, UC). Children were treatment na?ve at the time of sampling. A cohort of 36 children who were attending DDUH were grouped as a healthy control (HC) group. DNA was extracted from tongue and buccal swabs and the V1-V2 region of the 16S gene and ITS2 barcode of fungal DNA were amplified and sequenced using the Illumina MiSeq. Sequences were analysed with the Mothur and DADA2 pipelines. Additionally, IBD children following therapy were also analysed. Results: The tongue and buccal microbiota of CD children exhibted reduced biodiversity and lower species richness compared to healthy children. Our finding shows a reduction in the levels of several major oral bacterial genera, including Veillonella, and H. parinfluenza, and increased levels of oral Enterobacteriaceae and Actinobacteria in patients with severe IBD. Previous studies have implicated these taxa in the pathogenesis of IBD. In our follow up studies, remission from IBD symptoms was associated with loss of Enterobacteriaceae from the oral microbiome. We observed an increase in C. albicans and S. cerevisiae in the oral mycobiota in IBD. Interestingly, C. krusei and C. dubliniensis were also observed in the oral cavity in IBD. Overall, the mycobiome changes observed were more related to IBD disease activity compared to microbiome changes. Shifting of the oral microbial community was noted in follow up samples from patients after therapy, returning some taxa (Veillonella, Enterobacteriaceae) to levels close to the normal oral community. Conclusion: Children with IBD have an altered microbiota that may contribute to their oral health problems and may be linked to the pathogenesis of IBD. These data could potentially important to understand the aetiology of IBD and could be used in practical applications in diagnosis and monitoring disease progression. Advisors/Committee Members: Moran, Gary.

Subjects/Keywords: Oral microbiome and mycobiome; gut microbiomta; Crohn s disease; ulcerative colitis; dysbiosis; 16S and ITS2 profiling

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ELMAGHRAWY, K. M. (2019). Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/88800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ELMAGHRAWY, KHALID MUFTAH. “Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling.” 2019. Thesis, Trinity College Dublin. Accessed March 09, 2021. http://hdl.handle.net/2262/88800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ELMAGHRAWY, KHALID MUFTAH. “Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling.” 2019. Web. 09 Mar 2021.

Vancouver:

ELMAGHRAWY KM. Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2262/88800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ELMAGHRAWY KM. Analysis of the oral bacteriome and mycobiome in children with inflammatory bowel disease compared to healthy children by 16S and ITS2 profiling. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/88800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Central Florida

12. Rumsey, John. Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol.

Degree: 2004, University of Central Florida

URL: https://stars.library.ucf.edu/etd/236

► Mycobacterium avium subspecies paratuberculosis (map) is an intracellular pathogen that is known to parasitize macrophages and monocytes. Map infiltrates gastrointestinal tract host tissue where it… (more)

▼ Mycobacterium avium subspecies paratuberculosis (map) is an intracellular pathogen that is known to parasitize macrophages and monocytes. Map infiltrates gastrointestinal tract host tissue where it is the known etiological agent of johne's disease in ruminants and implicated in the etiology of crohn's disease in humans. Map's ability to survive within macrophages enables it to disseminate throughout the rest of the host, possibly infecting other circulating blood leukocytes. In this study, the survival and fate of map strain atcc 43015 (human isolate) following phagocytosis was determined using in vitro murine macrophage cell line j774a.1 and polymorphonuclear cells (pmnc's) from five crohn's disease patients. Pmnc's from three healthy individuals and two ulcerative colitis patients, as well as escherichia coli (atcc 11303) and mycobacterium tuberculosis strain h37ra (atcc 25177), were included as controls (moi 10:1). Maturation of the phagosome was determined by evaluating the presence of stage specific markers on the surface of the phagosomal membrane. The endosomal protein, transferrin receptor, and the lysosomal marker, lamp-1, were then immunostained with cy-5 conjugated secondary antibodies, and colocalization of bacteria with each marker was evaluated separately using confocal scanning laser microscopy (cslm). In both tissue models, colocalization of viable map and m. Tuberculosis with the early endosomal marker, transferrin receptor occurred with an estimated five fold higher frequency than did association with the late lysosomal marker, lamp-1, as compared to live e. Coli, and all dead bacterial species. Using differential live/dead staining and fluorescent microscopy, survival of m. Tuberculosis and map was estimated at 85% and 79%, respectively compared to only 14% for e. Coli. The outcome was similar for both tissue culture and pmncs from all patients tested, suggesting that map and m. Tuberculosis can survive readily in both cell types, and regardless of the disease state of the host or the killing power of the cell. Map's survival appears to mimic m. Tuberculosis', suggesting the ability to resist phagolysosome fusion, by maintaining association with the early endosomes. Overall, the data confirms map virulence in host human blood leukocytes. Advisors/Committee Members: Naser, Saleh.

Subjects/Keywords: Mycobacteria; polymorphonuclear leukocytes; Crohn s Disease; Microbiology; Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rumsey, J. (2004). Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol. (Masters Thesis). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/236

Chicago Manual of Style (16^th Edition):

Rumsey, John. “Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol.” 2004. Masters Thesis, University of Central Florida. Accessed March 09, 2021. https://stars.library.ucf.edu/etd/236.

MLA Handbook (7^th Edition):

Rumsey, John. “Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol.” 2004. Web. 09 Mar 2021.

Vancouver:

Rumsey J. Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol. [Internet] [Masters thesis]. University of Central Florida; 2004. [cited 2021 Mar 09]. Available from: https://stars.library.ucf.edu/etd/236.

Council of Science Editors:

Rumsey J. Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol. [Masters Thesis]. University of Central Florida; 2004. Available from: https://stars.library.ucf.edu/etd/236

Freie Universität Berlin

13. Becker, Janek. Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-28166

► Background and Aims: In patients with inflammatory bowel disease (IBD), restless legs syndrome (RLS) may occur as extraintestinal complication. A modified cerebral iron metabolism or… (more)

Subjects/Keywords: restless legs syndrome; cerebral iron metabolism; Crohn´s disease; ulcerative colitis; inflammatory bowel disease; ddc:610

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APA (6^th Edition):

Becker, J. (2020). Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-28166

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Becker, Janek. “Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution.” 2020. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-28166.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Becker, Janek. “Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution.” 2020. Web. 09 Mar 2021.

Vancouver:

Becker J. Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-28166.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Becker J. Prävalenz, klinische Charakteristika und Auswirkungen einer therapeutischen Eisensubstitution. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-28166

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Laranjeira, Nuno Filipe Dourado. Manifestações orais da doença inflamatória intestinal.

Degree: 2016, RCAAP

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/20113

►

Introdução: A doença inflamatória intestinal (DII) abrange uma gama de entidades clínicas cuja característica principal passa pela inflamação crónica do tubo digestivo em diferentes localizações,… (more)

▼

Introdução: A doença inflamatória intestinal (DII) abrange uma gama de entidades clínicas cuja característica principal passa pela inflamação crónica do tubo digestivo em diferentes localizações, sendo a colite ulcerosa (CU) e a doença de Crohn (DC) as formas mais representativas. Dada a sua associação a múltiplas manifestações extraintestinais, a DII pode atingir diferentes órgãos e sistemas do organismo, incluindo a cavidade oral. Objetivo: O objetivo do presente estudo foi o de verificar a existência de associação entre as alterações da cavidade oral e a DII. Materiais e Métodos: A amostra, de conveniência, foi selecionada no Hospital Garcia de Orta, em Almada, Portugal, sendo constituída por 171 indivíduos adultos de ambos os géneros, 113 doentes (65 com doença de Crohn e 48 com colite ulcerosa) e 58 controlos saudáveis. Foram determinados os valores do índice de dentes cariados perdidos e obturados (CPOD), do índice periodontal comunitário (IPC), do índice higiene oral simplificado (IHOS) e pesquisadas as mucosas orais para presença de lesões. Foram ainda obtidos dados referentes à sintomatologia oral, aos hábitos de higiene oral, hábitos tabágicos, terapêutica farmacológica, duração e atividade da doença inflamatória intestinal. Resultados: A sintomatologia oral, a doença periodontal e a cárie dentária, foram significativamente mais frequentes no grupo de doentes com DII. A sintomatologia oral e as lesões da mucosa oral foram mais acentuadas durante a fase ativa da DII. Não houve diferenças significativas entre as duas apresentações da doença (DC e CU) em nenhum dos parâmetros avaliados. A terapêutica com corticosteroides mostrou uma tendência para agravar a sintomatologia e as lesões da mucosa oral. Os hábitos tabágicos não mostraram modificar os parâmetros pesquisados. O duração clínica da DII mostrou agravar os índices CPOD, IPC e a presença de lesões da mucosa oral, no entanto nenhuma destas tendências se mostrou estatisticamente significativa. Conclusão: Foi possível verificar na população estudada que a cavidade oral é afetada pela DII. Estes doentes apresentaram maior frequência de sintomatologia oral e maior severidade de doença periodontal e de cárie do que o grupo de controlo. A atividade da DII mostrou acentuar a sintomatologia e as lesões da mucosa oral.

Introduction: Inflammatory bowel disease (IBD) encompasses a range of clinical entities. The most prominent feature is the chronic inflammation in different locations of the digestive tract. Ulcerative colitis (UC) and Crohn's disease (CD) are the most representative forms of IBD. Given its association with multiple extraintestinal manifestations, IBD is likely to target different organ systems, including the oral cavity. Aim: The aim of this study was to verify the existence of association between changes of the oral cavity and IBD. Materials and Methods: A convenience sample was selected at Hospital Garcia de Orta, Almada, Portugal, and consisted of 171 adult individuals of both genders, 113 patients (65 with Crohn's disease and 48 with…

Advisors/Committee Members: Leitão, Jorge Galvão Martins, Fonseca, Jorge Celso Dias Correia da.

Subjects/Keywords: Doença inflamatória intestinal; Doença de Crohn; Colite ulcerosa; Manifestações orais; Cárie; Doença periodontal; Lesões orais; Sintomatologia oral; Inflammatory Bowel Disease; Crohn´s disease; Ulcerative colitis; Oral manifestations; Tooth Decay; Periodontal disease; Oral lesions; Oral symptoms; Domínio/Área Científica::Ciências Médicas::Ciências da Saúde

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APA (6^th Edition):

Laranjeira, N. F. D. (2016). Manifestações orais da doença inflamatória intestinal. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/20113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Laranjeira, Nuno Filipe Dourado. “Manifestações orais da doença inflamatória intestinal.” 2016. Thesis, RCAAP. Accessed March 09, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/20113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Laranjeira, Nuno Filipe Dourado. “Manifestações orais da doença inflamatória intestinal.” 2016. Web. 09 Mar 2021.

Vancouver:

Laranjeira NFD. Manifestações orais da doença inflamatória intestinal. [Internet] [Thesis]. RCAAP; 2016. [cited 2021 Mar 09]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/20113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Laranjeira NFD. Manifestações orais da doença inflamatória intestinal. [Thesis]. RCAAP; 2016. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio.ucp.pt:10400.14/20113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Johansson, Annika. Förekomst av karies och parodontit hos personer med Morbus Crohn.

Degree: Health and Society, 2012, Kristianstad University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9308

►

Syftet med litteraturstudien var att undersöka förekomsten av karies och parodontit hos personer med Morbus Crohn. Metoden som användes var en allmän litteraturstudie. Materialet… (more)

▼

Syftet med litteraturstudien var att undersöka förekomsten av karies och parodontit hos personer med Morbus Crohn. Metoden som användes var en allmän litteraturstudie. Materialet till litteraturstudien samlades in genom sökning i databaserna Cinahl, PubMed och ScienceDirect. De sökord som användes vid litteratursökningen i samtliga databaser var ”caries”, ”Crohn’s disease”, ”periodontal disease” och ”periodontitis”. Vetenskapliga artiklar som fick ingå i litteraturstudien begränsades till ”English”, ”humans” och ”title/abstract” alternativt ”abstract/title/keywords”. Litteraturstudiens resultat baserades på en sammanställning av resultaten från tolv vetenskapliga artiklar. Tio av de vetenskapliga artiklarna berörde förekomst av karies hos personer med Morbus Crohn och i sju av dem redovisades att en signifikant förhöjd förekomst av karies fanns hos dessa personer. Tre av de tio vetenskapliga artiklarna redogjorde för att det fanns en förhöjd förekomst av karies hos personer med Morbus Crohn men det framgick inte om den var signifikant eller ej. Fem av de tolv vetenskapliga artiklarna berörde förekomst av parodontit hos personer med Morbus Crohn och i fyra av dem redovisades att en signifikant förhöjd förekomst av parodontit fanns hos dessa personer. Den kvarvarande vetenskapliga artikeln som berörde förekomst av parodontit hos personer med Morbus Crohn redogjorde för att det inte fanns en liten men inte signifikant förhöjd förekomst av parodontit hos dessa personer. Tre av de tolv vetenskapliga artiklarna berörde både förekomst av karies och parodontit hos personer med Morbus Crohn. Slutsatsen med litteraturstudien är att personer med Morbus Crohn verkar ha ökad förekomst av karies och parodontit.

The aim of the study was to investigate the occurrence of dental caries and periodontitis in people with Crohn’s disease. The method that was used in this study was a general literature review. The material for the literature review was collected by searching in the databases Cinahl, PubMed and ScienceDirect. The keywords that were used in the searches in all of the databases were ”caries”, ”Crohn’s disease”, ”periodontal disease” and ”periodontitis”. The scientific articles that were included in the literature review were limited to ”English”, ”humans” and ”title/abstract” alternatively ”abstract/title/keywords”. The result of the literature review was based on a compilation of the results from twelve scientific articles. Ten of the twelve scientific articles concerned the occurrence of dental caries in people with Crohn’s disease and seven of them reported a significantly elevated prevalence of dental caries in these individuals. Three of the ten scientific articles reported that there was an elevated incidence of dental caries in people with Crohn’s disease but they did not show whether the elevated incidence was significant or not. Five of the twelve scientific articles concerned the occurrence of periodontitis in people with Crohn’s disease and four of them reported a significantly elevated prevalence of…

Subjects/Keywords: Crohn´s disease; Dental caries; Occurrence; Oral health; Periodontitis; Förekomst; Karies; Morbus Crohn; Oral hälsa; Parodontit

…tandvårdspersonal att känna till om Morbus Crohn påverkar förekomsten av karies och parodontit, för att… …undersöka förekomsten av karies och parodontit hos personer med Morbus Crohn. 4. MATERIAL OCH… …av karies hos personer med Morbus Crohn (n=10). Den andra rubriken involverar… …vetenskapliga artiklar som berör förekomsten av parodontit hos personer med Morbus Crohn (n=5… …både karies och parodontit. 6.1. Förekomst av karies hos personer med Morbus Crohn I sju av…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johansson, A. (2012). Förekomst av karies och parodontit hos personer med Morbus Crohn. (Thesis). Kristianstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Annika. “Förekomst av karies och parodontit hos personer med Morbus Crohn.” 2012. Thesis, Kristianstad University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Annika. “Förekomst av karies och parodontit hos personer med Morbus Crohn.” 2012. Web. 09 Mar 2021.

Vancouver:

Johansson A. Förekomst av karies och parodontit hos personer med Morbus Crohn. [Internet] [Thesis]. Kristianstad University; 2012. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson A. Förekomst av karies och parodontit hos personer med Morbus Crohn. [Thesis]. Kristianstad University; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Trautmann, Dietmar. The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5001

► Crohn´s disease is a multifactorial chronic inflammatory disease of the gut, which is characterized by a Th1-type- and a Th17-type-immunopathology. A dysfunction of the gut… (more)

▼ Crohn´s disease is a multifactorial chronic inflammatory disease of the gut, which is characterized by a Th1-type- and a Th17-type-immunopathology. A dysfunction of the gut barrier is associated with a not fully understood cascade of inflammatory mediators and cytokines, among others TNF-alpha, IFN- gamma, Il-1, IL-6 und IL-17. An important role in the final tissue destruction is attributed to matrixmetalloproteinases as terminal mediators. At present the established therapy is mainly confined to alleviation of symptoms respectively concerning the TNF-alpha antibody therapy to immunmodulation, which however often leads to not inconsiderable side effects. Other therapies with less side effects are desirable. The oral infection of C57BL/6-mice with Toxoplasma gondii results in a Th1-type-immunopathology as well, characterized by the above-named inflammatory mediators and is suitable for the experimental study of terminal mediators within the inflammation cascade initiated by Toxoplasma gondii. Because of the extensive immunological similarities the oral infection of mice with Toxoplasma gondii serves as a model for Crohn´s disease and offers beside pathophysiological findings the possibility to investigate new therapy options. In this dissertation the increased expression of MMP-2 and MMP-9 in the terminal ileum of C57BL/6-mice following oral infection with Toxoplasma gondii could be shown using immunohistochemical staining. The expression of both gelatinases increases considerably on day 3 post infectionem and significantly until day 8. This concerns MMP-2 and MMP-9 to a similar extent. The expression correlates with intestinal pathology and loss of weight. Therapy with both specific and unspecific MMP-Inhibitors reduces intestinal pathology and loss of weight of Toxoplasma gondii-infected C57BL/6-mice considerably. Therefore the present paper could show the importance of MMP-2 and MMP-9 concerning the development of intestinal pathology in the context of a Th1-type-immunopathology in a mouse model following infection with Toxoplasma gondii. Direct MMP-Inhibition could serve as an therapy option for Crohn´s disease. However it has to be considerd that MMP-2 and MMP-9 are not the only mediators which contribute to intestinal pathology and that this would also not be a curative therapy. Other factors such as the pathophysiological impact of gut flora and other exogenic as well as endogenic components, which are etiologically jointly responsible, should be included in the discussion about therapy alternatives. Advisors/Committee Members: [email protected] (contact), m (gender), Prof. Dr. med. O. Liesenfeld (firstReferee), Prof. Dr. med. R. Somasundaram (furtherReferee), Prof. Dr. med. S. Ehlers (furtherReferee).

Subjects/Keywords: IBD; Crohn´s disease; CD; MMP-2; MMP-9; Toxoplasma gondii; matrixmetalloproteinases; gut; Th1-type-immunopathology; Doxycyclin; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Trautmann, D. (2013). The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Trautmann, Dietmar. “The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii.” 2013. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-5001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Trautmann, Dietmar. “The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii.” 2013. Web. 09 Mar 2021.

Vancouver:

Trautmann D. The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-5001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Trautmann D. The role of matrixmetalloproteinases 2 and 9 in intestinal Th1-type- immunopathology following peroral infection of mice with Toxoplasma gondii. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-5001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Jödicke, Lisa Joanna. T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-2571

► Introduction: Obesity and Crohn´s disease (CD) respresent diseases increasing worldwide. Both involve an inflammation of visceral adipose tissue (VAT). In hypertrophic, obese VAT, a low-grade… (more)

▼ Introduction: Obesity and Crohn´s disease (CD) respresent diseases increasing worldwide. Both involve an inflammation of visceral adipose tissue (VAT). In hypertrophic, obese VAT, a low-grade inflammation has been associated with insulin resistance. Observations in obese patients imply an impairment of intestinal barrier function and an altered disease course in obese CD patients. In CD patients a pathognomonic fat wrapping occurs around inflamed regions of the intestine, the so-called creeping fat (CF). However, the exact function of this tissue, consisting of a hyperplasia of small-sized adipocytes and infiltrating leukocytes, remains unsolved. Both a protective and a contributing role towards intestinal inflammation are discussed. This study characterized T-cell subpopulations in VAT from obese patients as well as adipose tissue and adjacent mucosa in inflammatory bowel disease (IBD) patients. The study also focuses on expression of the gut-homing integrin α4β7. Methods: VAT (and in IBD patients mucosal) samples were obtained from 47 patients undergoing disease-related surgery. Fractions were fixed and stained for immunohistochemistry. Immune cells were isolated, stained and analyzed by flow cytometry. Cytometric bead array (CBA) was performed to quantify cytokine release in adipose tissue supernatants. Results: In obese VAT a high proportion of T-cells expressed integrin α4β7, significantly more than in subcutaneous adipose tissue. VAT was dominated by a pro-inflammatory T-cell milieu. Macroscopic differences were found between colonic and ileal CF. Histology showed significantly smaller adipocytes and a high absolute T-cell infiltration only in ileal CF. Colonic CF resembled fat from UC patients. T-cell populations differed between IBD groups, ileal CF standing out by a higher amount of regulatory T-cells (Treg) and central memory T-cells. Furthermore, T-cells in ileal CF and mucosa consisted of distinct subgroups. Correlation of adipose tissue T-helper cell and Treg share with disease activity was inverse in ileal and colonic CF. When comparing obese VAT with ileal CF, VAT showed a higher amount of pro-inflammatory T-cells, also significantly more T-cells were α4β7-positive. Conclusion: In obese VAT α4β7+ T-cells are present in a pro-inflammatory milieu. These cells could be involved in intestinal barrier impairment and exacerbation of CD in obese individuals. Ileal CF from CD patients presents a more balanced T-cell infiltration compared to VAT in obese individuals. Interestingly, ileal and colonic CF differ regarding macroscopic and histological aspects, composition of T-cells and correlation with disease activity. This supports genetic data placing colonic CD between ileal CD and UC. Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: Crohn´s disease; T-cells; Morbid obesity; Visceral adipose tissue; Creeping fat; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jödicke, L. J. (2019). T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-2571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jödicke, Lisa Joanna. “T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna.” 2019. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-2571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jödicke, Lisa Joanna. “T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna.” 2019. Web. 09 Mar 2021.

Vancouver:

Jödicke LJ. T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-2571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jödicke LJ. T-Zell-Subtypen im Fettgewebe - Die Beziehung zwischen Fettgewebsinflammation und intestinaler Inflammation bei Patienten mit Morbus Crohn und Adipositas per magna. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-2571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Franz, Sabine. Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12661

► The progressive course of chronic inflammatory bowel disease (IBD) remains a challenge to treat. Immunosuppressive, immunomodulatory and immunostimulatory therapy models are the subject of controversial… (more)

▼ The progressive course of chronic inflammatory bowel disease (IBD) remains a challenge to treat. Immunosuppressive, immunomodulatory and immunostimulatory therapy models are the subject of controversial debate. Against this background, the effects of chronic immunosuppressive therapy as compared with conventional anti-inflammatory therapy were of interest. The disease progression of 41 IBD patients ulcerative colitis (UC) 30, crohn`s disease (CD) 6, indeterminate colitis (CI) 5, who, on account of advanced primary sclerosing cholangitis (PSC), had predominantly undergone a liver transplant, was compared with a control group consisting of 42 (UC 29, CD 11, CI 2) IBD patients, who did not undergo a transplant, assessed by means of retrospective data collection, standardised surveys and updated telephone interviews. After the transplant, oral types of immunosuppressive medication, such as cyclosporine A, tacrolimus, and mycophenolate mofetil (MMF), were applied. On the one hand, analyses were carried out by means of non-parametric test procedures, according to short-term schemes of treatment at time intervals (6 month-intervals) irrespective of the patient; on the other hand, the Kaplan- Meier method was applied at time intervals of more than 6 months (long-term therapy). In the longitudinal analysis, after 14.5 years, 22 out of 41 patients in the transplant group remained permanently in remission (p = 0.0295) in comparison with 14 out of 42 of the control group patients. All three types of immunosuppressive medication were associated with remission inductions (cyclosporine: p =0.000, tacrolimus: p =0.000, MMF: p =0.001). However, stable remission after 14.5 years was observed only during MMF therapy (p =0.000). In the immunosuppressive group, over the course, 3 colectomies (UC patients) were necessary, compared with 7 within the control group (3 UC, 4 CD patients). Furthermore, in the immunosuppressive group, over the entire course, 5 cases of carcinoma arose, consisting of one case of colorectal carcinoma in those with UC (2.4%) and 2 cases of cholangiocellular carcinoma. In the control group, 4 cases of carcinoma occurred, among which there was also one case of colorectal carcinoma in those with UC (2.4%) and one case of cholangiocellular carcinoma. Extra intestinal symptoms occurred as arthropathies during cyclosporine (p=0.000) and tacrolimus therapy (p=0.000). Side effects observed in cyclosporine were attributed to dermatological (p=0.005) classification, in tacrolimus to cardiovascular (p=0.000) classification and during MMF medication, to dermatological (p=0.011) and pulmonological (p=0.006) classification. 16 patients were completely free from IBD symptoms immediately after the transplant; more than a year after the transplant there were only 9 patients. Progression of the IBD symptoms following liver transplant was only evident in CI patients (4 patients, while initially 1 patient). By deduction, on the one hand, in comparison with other studies, the incidence of colorectal carcinoma in long-term… Advisors/Committee Members: w (gender), Priv.-Doz. Dr. med. A. Pascher (firstReferee), Prof. Dr. med. A. Dignaß (furtherReferee), Prof. Dr. med. T. Steinmüller (furtherReferee).

Subjects/Keywords: ulcerative colitis; crohn`s disease; indeterminate colitis; cyclosporin a; tacrolimus; mycophenolate mofetil; liver-transplant; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA (6^th Edition):

Franz, S. (2011). Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Franz, Sabine. “Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation.” 2011. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-12661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Franz, Sabine. “Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation.” 2011. Web. 09 Mar 2021.

Vancouver:

Franz S. Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-12661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Franz S. Effects of long-term immunosuppression in inflammatory bowel-disease-patients undergone liver-transplantation. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-12661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Rasche, Katerina. Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-26707

► Background: Deficient immunoregulation through CD4+CD25+ Forkhead-box protein(FOX)P3+ regulatory T-cells (Treg) can cause Crohn´s disease. Therefore, Treg were phenotypically characterized. Establishing transforming growth factor (TGF)β induced… (more)

Subjects/Keywords: Crohn´s disease; FOXP3; Regulatory T cell; Induced Treg; Treg; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rasche, K. (2020). Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rasche, Katerina. “Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn.” 2020. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-26707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rasche, Katerina. “Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn.” 2020. Web. 09 Mar 2021.

Vancouver:

Rasche K. Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-26707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rasche K. Induktion regulatorischer T Zellen bei Patienten mit Morbus Crohn. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-26707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Central Florida

20. Safavi-Khasraghi, Mitra. Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification.

Degree: 2006, University of Central Florida

URL: https://stars.library.ucf.edu/etd/964

► Despite the fact that E. coli supports limited posttranslational modification, this bacterium has been universally used as the expression system of choice. Expression of modified… (more)

▼ Despite the fact that E. coli supports limited posttranslational modification, this bacterium has been universally used as the expression system of choice. Expression of modified proteins in E. coli may lead to expression of recombinant proteins that lack essential immunomodulatory or catalytic components essentials for infectious processes. Previously in our laboratory, pMptb#28 plasmid containing a 4.8 kb insert from M. paratuberculosis has been identified which expressed 16 kDa recombinant protein in E. coli and 19 kDa recombinant protein in Mycobacterium smegmatis. The objective of this study is to identify the ORF sequence, investigate possible posttranslational modification and characterize the protein forms in the two hosts. Earlier in the study, the genome sequence for M. paratuberculosis was not available and therefore sequencing both the 5' and 3' ends of the 4.8 kb insert did not help in the identification of the ORF. However, unidirectional Exonuclease deletion resulted in identification of subclones containing possible ORF sequence. Later on, the publication of the M. paratuberculosis genome sequence along with BLAST analysis of sequences from the subclones resulted in the identification of 486 bp ORF with significant identity to that from M. tuberculosis and M. leprae. Cloning of the 486 ORF coding sequence in E. coli resulted in the expression of 16 kDa protein similar to the calculated predicted size of translated peptide. Cloning of the 486 bp ORF coding sequence in M. smegmatis resulted in the expression of 19 kDa protein similar to that from M. paratuberculosis. The 16/19 kDa forms of the same protein were verified using rabbit anti-M. paratuberculosis antibodies adsorbed in E. coli and M. smegmatis lysates. The size of the 19 kDa proteins was not reduced following treatment with deglycosylation enzymes in absence of any enzyme inhibitors. The 19 kDa product was confirmed not be a glycoprotein when failed to react with ConA stain. The 16/19 kDa forms of the protein were evaluated against T-lymphocytes from Crohn's disease patients and normal controls. T- proliferation assay included controls such as PHA and PPD from M. paratuberculosis. There was not a significant difference between the two forms of the protein (16/19 kDa) against T-cell response from both populations. Overall, the study identified the ORF of the 19 kDa non-glycoprotein from M. paratuberculosis. Moreover, this is the first study which reports that the zoonotic M. paratuberculosis supports posttranslational modification similar to M. tuberculosis and M. leprae pathogens. Although the posttranslational modification component in this 19 kDa nonglycoprotein did not affect T- cell response, the finding is significant toward glycoproteins from M. paratuberculosis and their role in the pathogenesis of this bacterial infection in animals and humans. Advisors/Committee Members: Naser, Saleh.

Subjects/Keywords: Mycobacterium paratuberculosis; Mycobacterium smegmatis; posttranslational modification; Crohn s disease; Microbiology; Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Safavi-Khasraghi, M. (2006). Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification. (Masters Thesis). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/964

Chicago Manual of Style (16^th Edition):

Safavi-Khasraghi, Mitra. “Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification.” 2006. Masters Thesis, University of Central Florida. Accessed March 09, 2021. https://stars.library.ucf.edu/etd/964.

MLA Handbook (7^th Edition):

Safavi-Khasraghi, Mitra. “Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification.” 2006. Web. 09 Mar 2021.

Vancouver:

Safavi-Khasraghi M. Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification. [Internet] [Masters thesis]. University of Central Florida; 2006. [cited 2021 Mar 09]. Available from: https://stars.library.ucf.edu/etd/964.

Council of Science Editors:

Safavi-Khasraghi M. Expression And Characterization Of Mycobacterium Paratuberculosis 19kda With Posttranslational Modification. [Masters Thesis]. University of Central Florida; 2006. Available from: https://stars.library.ucf.edu/etd/964

21. Dewulf, Nathalie de Lourdes Souza. "Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais".

Degree: Mestrado, Clínica Médica, 2005, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/17/17138/tde-27122005-114027/ ;

► A adesão ao tratamento medicamentoso é um importante fator determinante no sucesso terapêutico. A adesão do paciente pode ser influenciada por fatores diversos, ligados à… (more)

▼ A adesão ao tratamento medicamentoso é um importante fator determinante no sucesso terapêutico. A adesão do paciente pode ser influenciada por fatores diversos, ligados à doença, ao tratamento, ao paciente, às condições sociais e econômicas, como também, relacionada ao sistema de saúde que o atende. Ainda que existam inúmeros estudos sobre a adesão ao tratamento em portadores com doenças crônicas, são escassas as investigações sobre este tema nas doenças inflamatórias intestinais. O presente trabalho teve o objetivo de avaliar a adesão ao tratamento medicamentoso e os possíveis fatores que a influenciam, em pacientes portadores de doenças inflamatórias intestinais (DII): doença de Crohn (DC) e retocolite ulcerativa (RCU), do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (HCFMRP), da Universidade de São Paulo. Como controles, foram investigados pacientes portadores de pancreatite crônica e insuficiência pancreática (PC), com medicação fornecida pelo hospital, tal como os pacientes portadores de DII. Foram também investigados pacientes portadores de afecções digestivas variadas (ADV), grupo no qual a medicação prescrita não era fornecida pelo hospital. Por meio de estudo transversal e indireto, foi realizada entrevista estruturada para avaliar a adesão de 110 pacientes, que foram caracterizados como apresentando maior ou menor grau de adesão. Esta classificação foi baseada no cotejo entre os dados do prontuário e os informados pelo paciente em entrevista, considerando a afirmação do paciente que usava a medicação e que conhecia o nome da droga em uso. Utilizou-se, também, o teste de Morisky, que permite avaliar o padrão de comportamento do paciente em relação ao uso diário do medicamento. Este teste consiste de quatro perguntas padronizadas relacionadas ao esquecimento, descuido com o horário de tomada do medicamento, percepção de efeitos colaterais e ausência de sintomas. Na análise dos medicamentos utilizados pelo paciente, foram observadas as seguintes proporções de pacientes classificados como menos aderentes: 15,4% em pacientes portadores de DC, 13,3% na RCU, 8,4% na PC e 16,6% nos pacientes do grupo ADV. Porém, o teste de Morisky mostrou as seguintes proporções de menos aderentes: 50% de pacientes portadores de DC, 63,3% na RCU, 54,2% na PC e 63,4% na ADV. Não houve diferenças estatisticamente significativas, entre os grupos de pacientes, tanto na análise dos medicamentos utilizados pelo paciente como pelos resultados do teste de Morisky. Em análise univariada, nenhum dos fatores demográficos, sociais, clínicos ou referentes ao tratamento medicamentoso apresentou relação estatisticamente significativa, comum a todos os grupos, que indicasse influência sobre a adesão ao tratamento. Apesar do alto grau de adesão, de acordo com a análise dos medicamentos utilizados, detectou-se alto percentual de não-adesão ao tratamento medicamentoso ligado ao comportamento habitual e independente do diagnóstico, ou do acesso gratuito aos medicamentos. Isto pode indicar a existência de um padrão específico de… Advisors/Committee Members: Troncon, Luiz Ernesto de Almeida.

Subjects/Keywords: adesão ao tratamento medicamentoso; compliance to drug therapy; Crohns disease; doença de Crohn; doença inflamatória intestinal; estudo de utilização de medicamento; inflammatory bowel disease; retocolite ulcerativa; ulcerative colitis; use of medication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dewulf, N. d. L. S. (2005). "Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais". (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17138/tde-27122005-114027/ ;

Chicago Manual of Style (16^th Edition):

Dewulf, Nathalie de Lourdes Souza. “"Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais".” 2005. Masters Thesis, University of São Paulo. Accessed March 09, 2021. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-27122005-114027/ ;.

MLA Handbook (7^th Edition):

Dewulf, Nathalie de Lourdes Souza. “"Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais".” 2005. Web. 09 Mar 2021.

Vancouver:

Dewulf NdLS. "Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais". [Internet] [Masters thesis]. University of São Paulo; 2005. [cited 2021 Mar 09]. Available from: http://www.teses.usp.br/teses/disponiveis/17/17138/tde-27122005-114027/ ;.

Council of Science Editors:

Dewulf NdLS. "Investigação sobre a adesão ao tratamento medicamentoso em pacientes com doenças inflamatórias intestinais". [Masters Thesis]. University of São Paulo; 2005. Available from: http://www.teses.usp.br/teses/disponiveis/17/17138/tde-27122005-114027/ ;

Freie Universität Berlin

22. Hengstermann, Susanne. Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease.

Degree: 2007, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6671

► Background: Only few data are available about the plasma fatty acid (FA) profile as well as antioxidant vitamins in inactive IBD compared with active IBD… (more)

▼ Background: Only few data are available about the plasma fatty acid (FA) profile as well as antioxidant vitamins in inactive IBD compared with active IBD patients and healthy controls (HC). Methods: To obtain a detailed overview of antioxidant vitamins and FA we analysed vitamin C, vitamin E, carotenoids (lycopene, lutein/zeaxanthin, β-cryptoxanthin, a-/β-carotene), saturated (SFA, C14:0, C15:0, C16:0, C18:0, C20:0, C22:0), mono-unsaturated (MUFA, C16:1n7, C18:1n7, C18:1n9, C22:1n9) and poly-unsaturated FA (PUFA, C18:2n6, C18:3n6, C20:3n6, C20:4n6, C22:4n6, C18:3n3, C20:5n3, C20:6n3, C22:5n3, C22:6n3) in plasma. Inflammatory parameters (CRP; a-1-acid glycoprotein, AAG; faecal calprotectin, FC) as well as clinical disease activity (CDAI, CAI) were determined in 167 IBD patients and 45 sex, age and BMI matched HC. The IBD study groups consisted of 138 inactive IBD (83 Crohn s disease, CD, 49 ulcerative colitis, UC) and 35 active IBD patients (17 CD, 18 UC). Results: Overall nutritional status was normal in inactive (BMI 23.9±4.7 kg/m2), active (22.7±4.2 kg/m2) IBD patients and HC (22.3±1.9 kg/m2). Inflammatory parameters (CRP, AAG, FC) were significantly increased in inactive and active IBD in comparison to HC. Plasma levels of carotenoids differed significantly between inactive and active IBD as well as between inactive/active IBD and HC. Significantly decreased plasma levels of vitamin C, increased levels of MUFA and comparable levels of vitamin E, SFA and PUFA have been found between inactive/active IBD and HC. FA inversely correlated with FC, vitamin C and total carotenoids were found to inversely correlate with FC, CRP and AAG in IBD patients. Discussion: This study showed for the first time that antioxidant status and FA profile in a large population of inactive and active IBD patients are disturbed independently from disease activity as compared to matched HC, despite normal overall nutritional status. The compromised status of antioxidant vitamins might offer a therapeutic opportunity to improve antioxidant and inflammatory status. Advisors/Committee Members: n (gender), Prof. Dr. Herbert Lochs (firstReferee), Prof. Dr. Stefan Bischoff (furtherReferee), Prof. Dr. Hartmut Schmidt (furtherReferee).

Subjects/Keywords: micronutrients; fatty acids; nutritional status; ulcerative colitis; Crohn s disease; remission; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hengstermann, S. (2007). Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hengstermann, Susanne. “Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease.” 2007. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-6671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hengstermann, Susanne. “Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease.” 2007. Web. 09 Mar 2021.

Vancouver:

Hengstermann S. Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease. [Internet] [Thesis]. Freie Universität Berlin; 2007. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-6671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hengstermann S. Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease. [Thesis]. Freie Universität Berlin; 2007. Available from: http://dx.doi.org/10.17169/refubium-6671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Troschke, Ilka. Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro.

Degree: 2008, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11312

► Introduction: Although probiotic Escherichia coli strain Nissle 1917 (EcN) has been proven to be efficacious to maintain remission of ulcerative colitis and pouchitis, the underlying… (more)

▼ Introduction: Although probiotic Escherichia coli strain Nissle 1917 (EcN) has been proven to be efficacious to maintain remission of ulcerative colitis and pouchitis, the underlying mechanisms of action still remain elusive. A major role in the initiation and perpetuation of chronic IBD is attributed to the luminal bacterial flora. Several studies have demonstrated that bacterial products can activate T cells via Toll-like receptors even in the absence of antigen-presenting cells or costimulatory molecules, suggesting a direct link between the luminal bacterial flora and the immune system. Aims: To explore the role of TLR`s and costimulatory molecules in the response of T cells towards EcN. Methods: Peripheral blood (PBMC) and lamina propria (LPMC) mononuclear cells from wildtype, TLR-2 and TLR-4 knockout mice were stimulated and cultered in the presence or absence of sterile filtered EcN supernatants (EcN-SC). Flow cytometry analysis was used to assess DNA content (PI), T-cell receptor and TLR expression. Cell adhesion to the ECM components fibronectin and collagen was measured by using an adhesion assay based on luminometric analysis of fluorescently labelled cells. TLR-negative HEK293 cells were stably transfected with hTLR-2 and hTLR-4 and stimulated in the presence and absence of EcN supernatants followed by measurement of NF-κB activity using a chemiluminescence assay. Results: EcN-SN significantly increases TLR-2 and TLR-4 expression in wildtype PBMC. EcN-SN significantly inhibits cell cycle progression of activated wildtype PBMC, but not PBMC from TLR-2 or -4 deficient mice. Further EcN-SN increases NF-κB activity in TLR-2 and TLR-4 transfected HEK293 cells and inhibits adhesion of Wildtype and TLR-2 PBMC and LPMC to collagen and fibronectin. In contrast, the inhibition of T-cell adhesion to fibronectin is reduced in TLR-2 T-cells. Discussion: We firstly demonstrated that cell free supernatants of EcN distinctively modulates T cell function. EcN increases TLR-2 and -4 expression and activate NF-κB via these receptors. Consequently, inhibition of T cell cycling by EcN is not observed in TLR-2 or -4 knockout mice, demonstrating that these receptors are crucial in mediating the effects of EcN to T cells. Whereas the effects of EcN on T cell activation are TLR-2 and -4 dependent, the inhibition t cell adhesion to the ECM to be only TLR-4 dependent, indicating that EcN use distinct signaling pathways to exert its broad biological functions. Advisors/Committee Members: n (gender), Priv.-Doz. Dr. med. A.Sturm (firstReferee), Priv.-Doz. Dr. med. C.Maaser (furtherReferee), Priv.-Doz. Dr. med. B.Siegmund (furtherReferee).

Subjects/Keywords: Inflammatory bowel disease, Crohn’; s disease, ulcerative colitis, Escherichia coli; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Troschke, I. (2008). Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Troschke, Ilka. “Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro.” 2008. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-11312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Troschke, Ilka. “Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro.” 2008. Web. 09 Mar 2021.

Vancouver:

Troschke I. Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro. [Internet] [Thesis]. Freie Universität Berlin; 2008. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-11312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Troschke I. Signal transduction and signal processing of the probiotic bakterium E. coli Nissle 1917 in vitro. [Thesis]. Freie Universität Berlin; 2008. Available from: http://dx.doi.org/10.17169/refubium-11312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Lasson, Anders. Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure.

Degree: 2014, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/36736

► Fecal Calprotectin The usefulness in special clinical situations and issues on the sampling procedure Anders Lasson Department of Internal Medicine Institute of Medicine at the… (more)

▼ Fecal Calprotectin The usefulness in special clinical situations and issues on the sampling procedure Anders Lasson Department of Internal Medicine Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Sweden Ulcerative colitis and Crohnʼs disease are chronic inflammatory bowel diseases (IBD) of unknown etiology. In recent years, mucosal healing has emerged as the goal for therapy to achieve long-term remission and to change the natural course of IBD. Thus, it is essential to monitor thoroughly the disease activity. Fecal calprotectin is the best available biomarker of disease activity in IBD. The overall aim of this thesis was to study the clinical usefulness of fecal calprotectin. Four different patient cohorts were investigated. For patients with active ulcerative colitis, the fecal calprotectin levels varied considerably, even over a single day, and the variability was considered to be clinically important in up to one-third of the patients. However, the longer the time period between bowel movements, the higher were the concentrations of calprotectin. To reduce both the impact of the variability and the risk of false low calprotectin values, samples should be obtained from the first stool passed in the morning. In stool samples stored at room temperature, the concentrations of calprotectin were stable for 3 days, while the levels decreased significantly after 7 days. In a questionnaire, the patients declared that they did not find it burdensome to obtain stool samples, although suitable equipment was considered desirable. The levels of fecal calprotectin did not distinguish between patients with endoscopic recurrence 1 year after ileocaecal resection for Crohn’s disease and those without. However, in patients with low calprotectin values, endoscopic remission was commonly noted, suggesting that a colonoscopy might be avoided in these cases. In the group of patients with quiescent ulcerative colitis, dose escalation of 5-aminosalicylic acid (5-ASA) in those patients identified with increased levels of calprotectin significantly reduced the relapse rate. However, the overall relapse rate of the intervention group was not significantly lower than that of the control group. At cut-off values for calprotectin of 169 µg/g and 262 µg/g, the clinical course in patients with newly diagnosed ulcerative colitis could be predicted with good specificity and moderate sensitivity, for 1 and 3 years, respectively. Conclusions: These results facilitate standardization of the stool sampling procedure, which is necessary to improve the accuracy of this biomarker. Furthermore, fecal calprotectin might be used to select patients for ileocolonoscopy 1 year after ileocaecal resection for Crohnʼs disease. To treat patients with IBD in clinical remission, but with increased values of calprotectin suggesting subclinical disease activity, brings a new dimension to IBD care. In this context, dose escalation of 5-ASA may be appropriate in patients with ulcerative colitis. This therapeutic concept should be tested…

Subjects/Keywords: Inflammatory bowel disease; ulcerative colitis; Crohn´s disease; fecal biomarker; calprotectin; 5-aminosalicylic acid; ileocaecal resection; colonoscopy

…described in 1932 by Dr Burril B Crohn in a paper with the title Regional Ileitis: A Pathologic… …disease is not so serious. Although the magnitude of the colorectal cancer risk in Crohn colitis… …one of more than 20 proteins in the so-called S-100 family. These proteins were named…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lasson, A. (2014). Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/36736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lasson, Anders. “Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 09, 2021. http://hdl.handle.net/2077/36736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lasson, Anders. “Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure.” 2014. Web. 09 Mar 2021.

Vancouver:

Lasson A. Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2077/36736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lasson A. Fecal calprotectin - the usefulness in special clinical situations and issues on the sampling procedure. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/36736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. Mayr, Bastian. The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa.

Degree: 2007, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13033

► Background: Inflammatory bowel diseases can be associated with high endotoxin levels due to epithelial barrier disfunction. Therefore the effects of Lipopolysaccharide (LPS) on epithelial transport… (more)

Subjects/Keywords: Barrier function; intestinal permeability; Crohn s disease; ulcerative colitis; bacteremia; hydrochloric acid; lipopolysaccharide; TGF-ß1; dioctahedral smectite; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mayr, B. (2007). The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13033

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mayr, Bastian. “The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa.” 2007. Thesis, Freie Universität Berlin. Accessed March 09, 2021. http://dx.doi.org/10.17169/refubium-13033.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mayr, Bastian. “The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa.” 2007. Web. 09 Mar 2021.

Vancouver:

Mayr B. The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa. [Internet] [Thesis]. Freie Universität Berlin; 2007. [cited 2021 Mar 09]. Available from: http://dx.doi.org/10.17169/refubium-13033.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mayr B. The Effect of lipopolysaccharide on intact and experimentally injured human colon mucosa. [Thesis]. Freie Universität Berlin; 2007. Available from: http://dx.doi.org/10.17169/refubium-13033

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

26. Carlsson, Eva 1959-. Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome.

Degree: 2003, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/15992

► Patients with IBD are at risk for intestinal disability (e.g. having a stoma, malnutrition). The general aim of the thesis was to investigate physiological, psychological… (more)

▼ Patients with IBD are at risk for intestinal disability (e.g. having a stoma, malnutrition). The general aim of the thesis was to investigate physiological, psychological and social consequences of having IBD and an ileostomy or short bowel syndrome (SBS).Patients and Methods: Six SBS patients were interviewed to investigate practical aspects on daily life. In 21 ileostomates, and 19 patients with SBS, bioelectric impedance spectroscopy (BIS) was compared with other methods for determination of water compartments and fat free mass (FFM). Differences were analysed using the Bland-Altman method. Concerns, health related quality of life (HRQOL), quality of life (QOL) and coping were assessed in 21 patients with an ileostomy and 28 patients with SBS. HRQOL were compared with a matched group from the general population. Results: The differences between methods (BIS, Dual-energy absorptiometry (DXA), Dilution and derived estimates) to assess total body water (TBW) and FFM were pronounced. The mean difference of extracellular water (ECW) between dilution and BIS was less in female ileostomates than male, (p<0.01). Hydration of FFM assessed by BIS gave a mean of 0.77 for ileostomates and 0.75 for SBS patients. Most SBS patients were maintained in a stable clinical condition within normal limits of body weight and BMI.The most serious limitation of every day life for SBS patients was the planning involved to get most out of life. Dominating concerns for the ileostomates were intimacy, access to quality medical care and energy level and for the SBS patients being a burden, further surgery and energy level. Vitality was significantly reduced in ileostomates. In SBS patients all dimensions in HRQOL were significantly reduced except physical function. More than 1/3 of SBS patients rated health worse or much worse than one year ago. Most definitions on " good quality of life " were found in the social dimension. Most " obstacles to good quality of life" were found in the psychological dimension for the ileostomates and in the physical dimension for the SBS patients. Perceived QOL was rated 70/100 for ileostomates and 64/100 for the SBS patients. Confrontation was the dominating coping style.Conclusion: The differences between methods to assess body water compartments and FFM were pronounced. Methods could not be used interchangeably. BIS should be further evaluated with repeated, longitudinal measurements. The high concern for being a burden needs further investigation and how it can be reduced. Concern for intimacy as the concern for loss of sexual drive and sexual performance needs to be further explored. Fatigue needs to be defined. It is also necessary to study how concern changes over time. Integrating items of concern into counselling may result in greater coping ability and improved QOL.Key words; inflammatory bowel disease, Crohn´s disease, ulcerative colitis, short bowel syndrome, quality of life, health related quality of life, coping, concern, body composition, bioelectric impedance spectroscopy, Dual-energy…

Subjects/Keywords: inflammatory bowel disease; Crohn´s disease; ulcerative colitis; short bowel syndrome; quality of life; health related quality of life; coping; concern; body composition; bioelectric impedance spectroscopy; Dual-energy absorptiometry; total body water

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carlsson, E. 1. (2003). Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/15992

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carlsson, Eva 1959-. “Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome.” 2003. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 09, 2021. http://hdl.handle.net/2077/15992.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carlsson, Eva 1959-. “Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome.” 2003. Web. 09 Mar 2021.

Vancouver:

Carlsson E1. Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2003. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2077/15992.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carlsson E1. Body composition and quality of life in patients with IBD, ileostomy and short bowel syndrome. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2003. Available from: http://hdl.handle.net/2077/15992

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations