You searched for subject:(Creatine).
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Texas A&M University
1.
Dalton, Ryan Lee.
Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion.
Degree: PhD, Kinesiology, 2017, Texas A&M University
URL: http://hdl.handle.net/1969.1/173038 
► Creatine and nitrates are popular dietary supplements, but little is known regarding their co-ingestion relative to performance, side effects and safety. The purpose of this…
(more)
▼ Creatine and nitrates are popular dietary supplements, but little is known regarding their co-ingestion relative to performance, side effects and safety. The purpose of this study was to examine the safety and efficacy of a
creatine nitrate dietary supplement. In a double-blind, crossover, randomized and placebo-controlled manner; 28 apparently healthy and recreationally active men and women ingested daily supplements for 7 days consisting of a dextrose flavored placebo; a low dose of
creatine nitrate and a high dose of
creatine nitrate. Participants repeated the experiment with the alternate supplements with a 7 day washout period between each. Blood pressure, heart rate, blood samples, body weight, body composition, side effects questionnaires, bench press, leg press, and cycle ergometry performance were measured during each supplement period. No differences among treatments were found for any of the hemodynamic responses. No blood measurements exceeded normal clinical limits among treatments. No significant differences were observed in body composition or reported side effects among treatments. Pairwise comparisons found a significant difference between CNH and PLA, but not CNL at day 5 pre supplementation (PLA: 0.3 [-0.8, 1.5], CNL: 0.9 [-0.3, 2.1], CNH: 2.7 [1.6, 3.9], p=0.01) and a significant decrease in PLA and CNL, but not CNH, at day 5 post supplementation (PLA: -4.2 [-5.7, -2.7], CNL: -4.2 [-5.7, -2.7], CNH: -1.8 [-3.3, -0.3], p=0.01) in bench press 1RM and in leg press 1RM (PLA: -13.9 [-23.1, -4.7], CNL: -13.2 [-22.3, -4.0], CNH: -6.0 [-15.2, 3.1], p=0.01). No other changes were noticed in any of the performance variables.
Creatine nitrate supplementation appears to be safe and enhance performance at the doses and for the duration studied.
Advisors/Committee Members: Kreider, Richard B (advisor), Fluckey, James D (committee member), Woodman, Christopher R (committee member), Turner, Nancy D (committee member).
Subjects/Keywords: Creatine; Nitrate; Creatine Nitrate
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APA (6th Edition):
Dalton, R. L. (2017). Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173038
Chicago Manual of Style (16th Edition):
Dalton, Ryan Lee. “Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion.” 2017. Doctoral Dissertation, Texas A&M University. Accessed March 04, 2021.
http://hdl.handle.net/1969.1/173038.
MLA Handbook (7th Edition):
Dalton, Ryan Lee. “Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion.” 2017. Web. 04 Mar 2021.
Vancouver:
Dalton RL. Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1969.1/173038.
Council of Science Editors:
Dalton RL. Short-term Safety and Dose Effects of Different Forms of Creatine Ingestion. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/173038
University of Toronto
2.
Robinson, Nicholas.
Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?.
Degree: 2017, University of Toronto
URL: http://hdl.handle.net/1807/77888
► Creatine supplementation (Cr+) is known to increase recovery between exercise bouts and may increase force production capabilities of skeletal muscle. Heat shock proteins (Hsps), are…
(more)
▼ Creatine supplementation (Cr+) is known to increase recovery between exercise bouts and may increase force production capabilities of skeletal muscle. Heat shock proteins (Hsps), are up-regulated in skeletal muscle following damage, particularly following lengthening contractions (LC). Two experiments were conducted to examine the effect of Cr supplementation (Cr+; 14 days @ 300mg/kg) on skeletal muscle damage following 15 and 25 LCs. In each the left tibilais anterior (TA) of (n=6) Cr+ and Cr- Sprague-Dawley rats underwent LCs (either 15 or 25). No significant differences in TA Hsp content were observed between Cr- and Cr+ animals following 25 LCs, with both showing elevated Hsp72 and 25 content. Fifteen LCs also significantly increased Hsp72 content in both groups, but Hsp25 was significantly elevated only in Cr- animals. In summary, Cr supplementation did not significantly reduce LC induced muscle damage. However, it remains possible that Cr supplementation may reduce stress following 15 LCs.
M.Sc.
Advisors/Committee Members: Locke, Marius, Exercise Sciences.
Subjects/Keywords: Creatine; Muscle; 0575
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APA (6th Edition):
Robinson, N. (2017). Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/77888
Chicago Manual of Style (16th Edition):
Robinson, Nicholas. “Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?.” 2017. Masters Thesis, University of Toronto. Accessed March 04, 2021.
http://hdl.handle.net/1807/77888.
MLA Handbook (7th Edition):
Robinson, Nicholas. “Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?.” 2017. Web. 04 Mar 2021.
Vancouver:
Robinson N. Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1807/77888.
Council of Science Editors:
Robinson N. Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage?. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/77888
Boise State University
3.
McDonough, Daniel.
Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises.
Degree: 2017, Boise State University
URL: https://scholarworks.boisestate.edu/td/1348
► The purpose of this study was to examine the acute effects of oral creatine hydrochloride (CrHCl) supplementation on three repeated bouts of bench press and…
(more)
▼ The purpose of this study was to examine the acute effects of oral creatine hydrochloride (CrHCl) supplementation on three repeated bouts of bench press and vertical jumping exercises and body composition measures (body weight (BW), fat-free mass (FFM) and fat mass (FM)). Methods: Fifteen resistance trained males completed 3 sets of the barbell bench press (70% 1RM) and 3 sets of the repeated counter-movement vertical jump (CMJ; 85% maximal CMJ height), with 2 min rest between sets, before and after a 7 d CrHCl intervention (4 g·day-1). A two-factor repeated measures ANOVA was used to determine significant main effects (time and set) with post-hoc Bonferroni analysis and interaction effects (time x set) for bench press and CMJ performances from pre- to post-intervention. A one-factor repeated measures ANOVA was used to assess pre- to post-intervention differences in body composition. Results: Significant main and interaction effects for time and set were found in the bench press from pre- to post-intervention (p < 0.005, for all) with Bonferroni analysis indicating increased performance on later sets (eg, Set 3 > Set 2 > Set 1, p < 0.005). Significant main effects for time and set were found in the CMJ test from pre- to post-intervention (p < 0.005) but no interaction effect was found (p > 0.05). Post hoc analysis indicated increased performance on later sets. BW was the only body measure to reach significance (p < 0.005). Conclusion: Supplementation with 4 g of CrHCl for 7 d in healthy, resistance trained men significantly increased the number of repetitions performed during intermittent bouts of submaximal bench press and CMJ exercises and body weight.
Subjects/Keywords: creatine; creatine hydrochloride; creatine HCl; ergogenic aids; exercise science; anaerobic exercise; Exercise Physiology
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APA (6th Edition):
McDonough, D. (2017). Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises. (Thesis). Boise State University. Retrieved from https://scholarworks.boisestate.edu/td/1348
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McDonough, Daniel. “Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises.” 2017. Thesis, Boise State University. Accessed March 04, 2021.
https://scholarworks.boisestate.edu/td/1348.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McDonough, Daniel. “Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises.” 2017. Web. 04 Mar 2021.
Vancouver:
McDonough D. Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises. [Internet] [Thesis]. Boise State University; 2017. [cited 2021 Mar 04].
Available from: https://scholarworks.boisestate.edu/td/1348.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McDonough D. Oral Creatine Hydrochloride Supplementation: Acute Effects on Submaximal, Intermittent Bouts of Bench Press and Vertical Jump Exercises. [Thesis]. Boise State University; 2017. Available from: https://scholarworks.boisestate.edu/td/1348
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Bowling Green State University
4.
Reuland, Emily Marie.
The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women.
Degree: MEd, Human Movement, Sport and Leisure Studies
/Kinesiology, 2016, Bowling Green State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1462549479
► Researchers have reported that creatine monohydrate is an effective ergogenic aid. With a lack of research on women and creatine hydrochloride, there was a need…
(more)
▼ Researchers have reported that
creatine monohydrate is
an effective ergogenic aid. With a lack of research on women and
creatine hydrochloride, there was a need for further research into
creatine hydrochloride’s effect on men versus women during
resistance training. This study compared the change in total
training volume (TTV) from a control trial to an experimental trial
between men and women who ingested either a placebo or a single
dose of 0.033 grams per kilogram of body weight of
creatine
hydrochloride. Both sexes in the
creatine group and the placebo
group significantly increased TTV from the control trial to the
experimental trial during the leg press, but there was no
significant change in TTV for the bench press. The change in TTV
for the leg press compared between the
creatine and placebo groups
was not significant. There was a significant difference between men
and women’s TTV, with women in the
creatine group performing more
total repetitions than men in the
creatine group during the leg
press. The efficacy of
creatine hydrochloride on resistance
training remains unclear.
Advisors/Committee Members: Morgan, Amy (Advisor).
Subjects/Keywords: Kinesiology; Nutrition; Creatine; Supplementation; Resistance Training; Women and Creatine Supplementation; Creatine Hydrochloride
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APA (6th Edition):
Reuland, E. M. (2016). The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women. (Masters Thesis). Bowling Green State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1462549479
Chicago Manual of Style (16th Edition):
Reuland, Emily Marie. “The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women.” 2016. Masters Thesis, Bowling Green State University. Accessed March 04, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1462549479.
MLA Handbook (7th Edition):
Reuland, Emily Marie. “The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women.” 2016. Web. 04 Mar 2021.
Vancouver:
Reuland EM. The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women. [Internet] [Masters thesis]. Bowling Green State University; 2016. [cited 2021 Mar 04].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1462549479.
Council of Science Editors:
Reuland EM. The Effects of a Single Dosage of Creatine Hydrochloride on
Total Training Volume in Resistance Trained Men Versus
Women. [Masters Thesis]. Bowling Green State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1462549479
University of Utah
5.
Levedahl, Blaine H.
Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;.
Degree: PhD, Biochemistry;, 1949, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1365/rec/201
► The metabolism of testosterone and methyltestosterone by liver and kidney tissue of several species has been investigated. In the livers of all species studied there…
(more)
▼ The metabolism of testosterone and methyltestosterone by liver and kidney tissue of several species has been investigated. In the livers of all species studied there appears to be an enzyme system that requires citrate as a cofactor. This system causes the destruction of the alpha-beta bonding which is found in ring A of many steroids. There is also present in the livers of all species studied except the rabbit an enzyme that requires diphosphopyridine nucleotide for its activity and oxidized the alcohol group at carbon -17 to a ketone. Kidney tissue contains the diphosphopyridine nucleotide – activated system but has very little activity on the alpha-beta conjugation. The effect of variation of diphosphopyridine nucleotide on the metabolism of testosterone by liver mince has been investigated. The effect noted on the metabolism of ring A was very small and errotic. The metabolism of carbon-17 apparently requires 3 mole of diphosphopyridine nucleotide per mole of steroid for maximum oxidation. It has been found that carbon-17 of methyltestosterone is not metabolized to form 17-ketone groups by either tissue. The methyl grouping at carbon-17 appears to block the action of the enzyme system which otherwise catalyzes the oxidation of the alcohol group to a ketone group. Ring A of the two steroids is metabolized by liver tissue to the same extent under similar conditions. It is therefore concluded that the metabolism of ring A for both compounds follows the same course and is perhaps carried out by the same enzyme systems. The alpha-beta conjugation in both compounds is destroyed only to be very slight extent in kidney tissue. Methyltestosterone labeled in the methyl group at carbon-17 with C14 has been incubated with liver mince. No. definite compound has been completely identified to data. However, it is clear that several products are formed during the incubation. These included a steroid component with a melting point of 220-235° C. and some organic acid. No single metabolic product accumulated in significant amounts. Methyltestosterone when incubated with testosterone in ratios as high as 2:1 did not act as inhibitor to the enzyme system that oxidizes carbon-17 of testosterone. There was no effect of either steroid on the formation of guanidoacetic acid, creatine, or creatinine by liver or kidney tissues. The addition of diphosphopyridine nucleotide and citrate led to an increase in both “apparent” creatine and “apparent” creatinine but this was unaffected by the presence of the steroids. When a paper chromatographic method was used to separate creatine and creatinine from other substances giving the Jaffe reaction, no increase in creatine was observed, but the marked increase in creatinine was confirmed. It was concluded that the ration of oral to subcutaneous activity can be explained by presence of one enzyme which acts on testosterone but no on methyltestosterone. The failure of other workers to isolate products of methyltestosterone metabolism in the urine is probably due to the number of such products, none of…
Subjects/Keywords: Metabolism; Creatine
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APA ·
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APA (6th Edition):
Levedahl, B. H. (1949). Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1365/rec/201
Chicago Manual of Style (16th Edition):
Levedahl, Blaine H. “Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;.” 1949. Doctoral Dissertation, University of Utah. Accessed March 04, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1365/rec/201.
MLA Handbook (7th Edition):
Levedahl, Blaine H. “Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;.” 1949. Web. 04 Mar 2021.
Vancouver:
Levedahl BH. Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;. [Internet] [Doctoral dissertation]. University of Utah; 1949. [cited 2021 Mar 04].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1365/rec/201.
Council of Science Editors:
Levedahl BH. Comparison of the metabolism of testosterone and methyltestosterone and their relation to the in vitro metabolism of creatine and guanidoacetic acid;. [Doctoral Dissertation]. University of Utah; 1949. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1365/rec/201
6.
Mo, Yoonsun.
Physicochemical Characterization of Creatine.
Degree: M.S. in Pharmaceutical Sciences, Pharmaceutical Science (graduate program), 2002, Creighton University
URL: http://hdl.handle.net/10504/68433
► Creatine is a naturally occurring guanidino compound. It is found in all types of muscle tissues, most of which are present in skeletal muscle and…
(more)
▼ Creatine is a naturally occurring guanidino compound. It is found in all types of muscle tissues, most of which are present in skeletal muscle and brain.
Creatine in its free or phosphrylated forms plays an important role in the regulation and homeostasis of muscle energy metabolism. It appears to increase lean body mass, high-intensity power output and strength in healthy human. Therefore, there has been great interest among both athletes and the scientific community regarding the therapeutic application of
creatine and its benefits as a dietary supplement. However, despite such interest, a little attempt has been made to determine solid-state properties and the oral bioavailability of
creatine. Currently,
creatine is available as a monohydrate or di-
creatine citrate salt form.|The aim of this study was to develop a simple and sensitive LC method for the determination of
creatine in aqueous solution as wel) as in rat plasma and characterize the solid-state properties of this compound.|Various HPLC methods have been reported for the analysis of
creatine. In most cases, reversed-phase ion-pairing HPLC with UV- photometric detection was utilized. However, not a single study was utilized electrochemical detection tor the determination of
creatine in aqueous and biological samples. Electrochemical detection not only offers superior sensitivity and limits of detection for non-aromatic compounds when compared to UV detection, but potentially can be canned out with a minimum of sample preparation. Therefore, a simple and sensitive LC method with pulsed electrochemical detection was developed and validated for the quantitation of
creatine in aqueous solution as well as in rat plasma. This method was further utilized to study the solid-state properties, the saturated solubility, and vitro dissolution characteristics of various
creatine salts.|In order to detennine solid-state properties of
creatine monohydrate, samples were subjected to thermal Analyses, Karl-Fisher titrimetry (KFT), scanning electron microscopy (SEM) and variable temperature X-ray powder difffactonietry (VTXRD). The results of this study suggested that commercially available
creatine monohydrate dehydrates at about 97-125°C. A phase transition after dehydration was confirmed by X-ray diffraction. This dehydrated phase at a temperature above 230°C undergoes intramolecular cyclization with a loss of an additional mole of water to form creatinine. Creatinine finally melts with decomposition at about 290°C. VTXRD, confirmed that the above solid- state thermal transfonnation was kinetically driven, and occurred within a narrow temperature range. Mass spectrometric (MS) studies further indicated a possible dimerization of creatinine formed during the solid- state transformation. The future direction of this work is to evaluate the oral bioavailability of different
creatine salts in an animal model.
Advisors/Committee Members: Dash, Alekha K. (advisor), Mo, Yoonsun (cuauthor).
Subjects/Keywords: Creatine – chemistry
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APA (6th Edition):
Mo, Y. (2002). Physicochemical Characterization of Creatine. (Masters Thesis). Creighton University. Retrieved from http://hdl.handle.net/10504/68433
Chicago Manual of Style (16th Edition):
Mo, Yoonsun. “Physicochemical Characterization of Creatine.” 2002. Masters Thesis, Creighton University. Accessed March 04, 2021.
http://hdl.handle.net/10504/68433.
MLA Handbook (7th Edition):
Mo, Yoonsun. “Physicochemical Characterization of Creatine.” 2002. Web. 04 Mar 2021.
Vancouver:
Mo Y. Physicochemical Characterization of Creatine. [Internet] [Masters thesis]. Creighton University; 2002. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10504/68433.
Council of Science Editors:
Mo Y. Physicochemical Characterization of Creatine. [Masters Thesis]. Creighton University; 2002. Available from: http://hdl.handle.net/10504/68433
University of Manitoba
7.
Alraddadi, Eman.
Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation.
Degree: Pharmacology and Therapeutics, 2016, University of Manitoba
URL: http://hdl.handle.net/1993/31184
► Little is known about the anti-inflammatory activity of creatine. The aim of this study was to evaluate the anti-inflammatory effects of creatine supplements in canine…
(more)
▼ Little is known about the anti-inflammatory activity of
creatine. The aim of this study was to evaluate the anti-inflammatory effects of
creatine supplements in canine chondrocytes (CnC). CnC were stimulated with IL-1β. Release of PGE2 and TNFa was measured using ELISA. Changes in oxylipin profile was assessed using HPLC/MS. Expression of COX-2 and phosphorylated NF-kB was performed using western blot. Changes in above inflammatory responses were examined following treatment with various
creatine compounds including the metabolite creatinine. COX inhibitor, Rimadyl, substantially reduced PGE2 release, despite increasing both TNFa release and COX-2 expression. All
creatine compounds, including creatinine, reduced PGE2, COX-2 and TNFa in stimulated CnC. In addition, all the compounds examined reduced phosphorylated NF-kB expression. The
creatine compounds were also able to interfere with the production of several oxylipins in response to IL-1β.
Creatine supplements may have a beneficial role in preventing inflammation within the joint and other tissues.
Advisors/Committee Members: Miller, Donald (Pharmacology and Therapeutics) (supervisor), Sitar, Daniel (Pharmacology and Therapeutics) Burczynski, Frank (Pharmacology) (examiningcommittee).
Subjects/Keywords: Creatine; Canine; Chondrocytes; Joint
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APA (6th Edition):
Alraddadi, E. (2016). Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31184
Chicago Manual of Style (16th Edition):
Alraddadi, Eman. “Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation.” 2016. Masters Thesis, University of Manitoba. Accessed March 04, 2021.
http://hdl.handle.net/1993/31184.
MLA Handbook (7th Edition):
Alraddadi, Eman. “Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation.” 2016. Web. 04 Mar 2021.
Vancouver:
Alraddadi E. Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1993/31184.
Council of Science Editors:
Alraddadi E. Evaluation of the Anti-Inflammatory Effects of Creatine in Canine Chondrocytes as an in-vitro Model of Joint Inflammation. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31184
University of New Mexico
8.
Fransen, Jeremy.
Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization.
Degree: Health, Exercise, and Sports Sciences, 2012, University of New Mexico
URL: http://hdl.handle.net/1928/20820
► The purpose of this dissertation was to identify the effect of creatine (Cr) supplementation during immobilization on muscle performance. Twenty-five healthy, active male (n =…
(more)
▼ The purpose of this dissertation was to identify the effect of
creatine (Cr) supplementation during immobilization on muscle performance. Twenty-five healthy, active male (n = 14; age 28 ± 5 years) and female (n = 11; age 22 ± 4 years) subjects performed wrist flexion exercise before (PRE) and after (POST) one week of wrist/forearm cast immobilization. During the immobilization period, subjects consumed Cr (20g) or placebo PL (4% CHO flavored solution) interspersed throughout the day. On the first day of immobilization subjects consumed two doses of Cr (10 g) or PL. Subjects consumed 5 g of Cr or PL on four occasions from day 2 to day 7 for a total of 20 g•d-1. On day 8, subjects were instructed to consume a total of 5 g CR or PL, and the cast was removed prior to POST test. Exercise was performed on a custom developed rotational ergometer device attached by a cord to suspended weights across a wall pulley. Wrist flexion exercise commenced with an incremental protocol to fatigue followed by a 4.8 min rest. Then constant-load exercise (CL1) was performed with the peak weight achieved in the incremental protocol for 2.4 min, followed by another 4.8 min rest. The second constant-load exercise bout (CL2) used the same weight as CL1 for a final 2.4 min endurance exercise bout. Total work and average power was quantified by the kg load, the distance the weight was lifted, and the time to conduct the work. Immobilization caused a significant decrement in forearm total work (-3.17 ± 2.27% PL; -2.61 ± 1.89% CR) and average power (-3.43 ± 2.35% PL; -2.61 ± 1.89% CR) during the incremental protocol, regardless of Cr supplementation. During the first CL bout, both total work and average power decreased in PL after immobilization (-28.9 ± 9.63%; p < 0.05), but not in CR. However, during CL2, both total work and average power decreased in CR (work -14.39 ± 4.54%; power -10.52 ± 4.6% and PL (work -21.98 ± 8.28%; power -21.3 ± 8.25%) groups after immobilization. The significance of these findings are; 1) 7 days of wrist immobilization will significantly decrease wrist flexion work and power, 2) this decrement can be slowed with Cr supplementation for an initial constant load exercise bout performance, and 3) however, this beneficial effect may be lost with repeated bouts of constant load exercise. Future research should help elucidate the underlying mechanisms of fatigue after immobilization to explain possible differences in incremental and constant load endurance exercise performance.
Advisors/Committee Members: Kravitz, Len, Schneider, Suzanne, Conn, Carole, Mermier, Christine.
Subjects/Keywords: Casting; Creatine; Muscle Endurance
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APA (6th Edition):
Fransen, J. (2012). Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization. (Doctoral Dissertation). University of New Mexico. Retrieved from http://hdl.handle.net/1928/20820
Chicago Manual of Style (16th Edition):
Fransen, Jeremy. “Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization.” 2012. Doctoral Dissertation, University of New Mexico. Accessed March 04, 2021.
http://hdl.handle.net/1928/20820.
MLA Handbook (7th Edition):
Fransen, Jeremy. “Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization.” 2012. Web. 04 Mar 2021.
Vancouver:
Fransen J. Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization. [Internet] [Doctoral dissertation]. University of New Mexico; 2012. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1928/20820.
Council of Science Editors:
Fransen J. Effect of Creatine Supplementation on Wrist Flexion Work and Power after Immobilization. [Doctoral Dissertation]. University of New Mexico; 2012. Available from: http://hdl.handle.net/1928/20820
Utah Valley University
9.
Mills, Heath.
Creatine's Effects.
Degree: 2002, Utah Valley University
URL: http://contentdm.uvu.edu:81/u?/UVUTheses,442
This thesis addresses the benefits and possible health hazards associated with the use of creatine to enhance athletic performance. The author also looks at ethical issues surrounding the manufacture and distribution of creatine by companies who are aware of the associated health problems.
26 pages; 22 cm.
Subjects/Keywords: Creatine; Creatine – Health aspects
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APA (6th Edition):
Mills, H. (2002). Creatine's Effects. (Thesis). Utah Valley University. Retrieved from http://contentdm.uvu.edu:81/u?/UVUTheses,442
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mills, Heath. “Creatine's Effects.” 2002. Thesis, Utah Valley University. Accessed March 04, 2021.
http://contentdm.uvu.edu:81/u?/UVUTheses,442.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mills, Heath. “Creatine's Effects.” 2002. Web. 04 Mar 2021.
Vancouver:
Mills H. Creatine's Effects. [Internet] [Thesis]. Utah Valley University; 2002. [cited 2021 Mar 04].
Available from: http://contentdm.uvu.edu:81/u?/UVUTheses,442.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mills H. Creatine's Effects. [Thesis]. Utah Valley University; 2002. Available from: http://contentdm.uvu.edu:81/u?/UVUTheses,442
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
10.
Galvan, Elfego.
Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance.
Degree: PhD, Kinesiology, 2015, Texas A&M University
URL: http://hdl.handle.net/1969.1/174207
► Creatine monohydrate (CrM) and nitrate are popular supplements for improving exercise performance; yet they have not been investigated in combination. We performed two studies to…
(more)
▼ Creatine monohydrate (CrM) and nitrate are popular supplements for improving exercise performance; yet they have not been investigated in combination. We performed two studies to determine the safety and exercise performance-characteristics of
creatine nitrate (CrN) supplementation.
In Study 1, 13 participants ingested 1.5 g CrN (CrN-L), 3 g CrN (CrN-H), 5 g CrM or a placebo (PL) in a crossover study to determine supplement safety. Hepatorenal and muscle enzymes, heart rate, blood pressure and side effects were measured before supplementation, 30 minutes after ingestion, and then hourly for 5 hours post-supplementation. In Study 2, 48 participants received the same CrN treatments vs. 3 g CrM in a double-blind, 28-day trial inclusive of a 7-day interim testing period and loading sequence (4 servings/d). Day-0 and day-28 measured bench press performance, Wingate testing and a 6x6-s bicycle ergometer sprints. Data were analyzed using a general linear model and results are reported as mean ± standard deviation or mean change ± 95% confidence interval (CI).
Both studies yielded several significant, yet stochastic changes in blood markers that were not indicative of potential harm or consistent for any treatment group. Equally, all treatment groups reported a similar number of minimal side effects. In Study 2, there was a significant increase in plasma nitrates for both CrN groups by day-7, subsequently abating by day-28. Muscle
creatine increased significantly by day-7 in the CrM and CrN-H groups, but decreased by day-28 for CrN-H. By day-28, there were significant increases in bench press lifting volume (kg) for all groups (PL, 126.6, 95% CI 26.3, 226.8; CrM, 194.1, 95% CI 89.0, 299.2; CrN-L, 118.3, 95% CI 26.1, 210.5; CrN-H, 267.2, 95% CI 175.0, 359.4, kg). Only the CrN-H group was significantly greater than PL (p<0.05). Similar findings were observed for bench press peak power (PL, 59.0, 95% CI 4.5, 113.4; CrM, 68.6, 95% CI 11.4, 125.8; CrN-L, 40.9, 95% CI -9.2, 91.0; CrN-H, 60.9, 95% CI 10.8, 111.1, Watts) and average power.
Creatine nitrate was well-tolerated, demonstrated similar performance benefits to 3 g CrM, and was void of significant hemodynamics or blood enzymes changes associated with supplement safety.
Advisors/Committee Members: Kreider, Richard B (advisor), Fluckey, James D (committee member), Riechman, Steven E (committee member), Smith, Stephen B (committee member).
Subjects/Keywords: Creatine; Nitrate; Creatine Nitrate; Nutrition; Supplementation; Exercise Performance
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APA (6th Edition):
Galvan, E. (2015). Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/174207
Chicago Manual of Style (16th Edition):
Galvan, Elfego. “Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance.” 2015. Doctoral Dissertation, Texas A&M University. Accessed March 04, 2021.
http://hdl.handle.net/1969.1/174207.
MLA Handbook (7th Edition):
Galvan, Elfego. “Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance.” 2015. Web. 04 Mar 2021.
Vancouver:
Galvan E. Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1969.1/174207.
Council of Science Editors:
Galvan E. Acute and Chronic Analysis of the Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/174207
University of Cincinnati
11.
Udobi, Kenea C.
The Critical Period for Creatine Transporter
Deficiency.
Degree: PhD, Medicine: Neuroscience/Medical Science Scholars
Interdisciplinary, 2018, University of Cincinnati
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838614741075
► The discovery of the creatine (Cr)-phosphocreatine (PCr) system has had profound impact on the understanding of cellular bioenergetics, physiology and human pathology. Cr is essential…
(more)
▼ The discovery of the
creatine (Cr)-phosphocreatine
(PCr) system has had profound impact on the understanding of
cellular bioenergetics, physiology and human pathology. Cr is
essential for maintaining ATP homeostasis by providing phosphate
pools that can quickly replenish ATP. The importance of Cr is
highlighted by individuals with cerebral Cr deficiency syndromes
(CCDSs), which are caused by a loss of Cr transport or synthesis.
CCDSs are characterized by a wide spectrum of neurological symptoms
with intellectual disability, epilepsy, and language impairments
being the most frequent. The predominantly neurologic phenotype of
CCDS indicates the importance of Cr in proper brain function. Of
the mutations that lead to CCDS,
Creatine transporter deficiency
(CTD) is the most prevalent, affecting 1-2% of males with X-linked
intellectual disability (ID). Despite the abundance of Cr in the
brain and the striking phenotype of CCDS, little is known about the
role Cr plays in brain function. Mouse models have provided
invaluable tools for the study of CCDSs. Ubiquitous Slc6a8 knockout
mice (Slc6a8-/y) possess a similar phenotype to CTD patients,
exhibiting cognitive deficits, and a lack of whole-body Cr but show
reductions in size and swim speed that could affect the
interpretation of the behavioral data and how subsequent
experiments should be designed. To address this, we created
brain-specific Slc6a8 knockout (bKO) mice that have reduced
cerebral Cr levels and normal Cr levels in peripheral tissue. The
bKO mice are similar in stature to wild-type mice and do not show
deficits in swim speed. Similar to Slc6a8-/y mice bKO mice have
cognitive deficits in the MWM, NOR and CF tasks. This suggests that
the Slc6a8-/y mouse is the best model of CTD, as it more closely
matches the biochemical phenotype of CTD. To determine the ontogeny
of the cognitive and metabolic deficits in CTD, we eliminated the
Slc6a8 gene ubiquitously in either adult (postnatal day (P) 60) or
neonatal (P5) mice. Both adult and neonatal knockout mice were
hyperactive in the open-field test. Elimination of the Slc6a8 gene
in adulthood did not result in learning and memory deficits. The P5
knockout mice showed spatial learning deficits evidenced by
increases in latency and path length during both phases of the MWM.
Neonatal knockout mice also had deficits in object recognition and
fear memory. Both groups of mice showed increases in whole-body
metabolism and mitochondrial respiration, consistent with Slc6a8-/y
mice. The results of this research suggest that cognitive deficits
seen in CTD result from changes in the brain due to Cr loss during
early brain development.
Advisors/Committee Members: Vorhees, Charles (Committee Chair).
Subjects/Keywords: Neurology; creatine; cellular metabolism; mitochondria; intellectual disability; creatine transporter
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APA (6th Edition):
Udobi, K. C. (2018). The Critical Period for Creatine Transporter
Deficiency. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838614741075
Chicago Manual of Style (16th Edition):
Udobi, Kenea C. “The Critical Period for Creatine Transporter
Deficiency.” 2018. Doctoral Dissertation, University of Cincinnati. Accessed March 04, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838614741075.
MLA Handbook (7th Edition):
Udobi, Kenea C. “The Critical Period for Creatine Transporter
Deficiency.” 2018. Web. 04 Mar 2021.
Vancouver:
Udobi KC. The Critical Period for Creatine Transporter
Deficiency. [Internet] [Doctoral dissertation]. University of Cincinnati; 2018. [cited 2021 Mar 04].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838614741075.
Council of Science Editors:
Udobi KC. The Critical Period for Creatine Transporter
Deficiency. [Doctoral Dissertation]. University of Cincinnati; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838614741075
University of Pretoria
12.
Rossouw, France.
Safety and
effect of creatine monohydrate supplementation.
Degree: Biokinetics, Sport and Leisure
Sciences, 2013, University of Pretoria
URL: http://hdl.handle.net/2263/32947
► Creatine (Cr) is a nitrogen-containing compound endogenously synthesised in the kidneys, liver and pancreas from the amino acid arginine, with further additions from glycine and…
(more)
▼ Creatine (Cr) is a nitrogen-containing compound
endogenously synthesised in the kidneys, liver and pancreas from
the amino acid arginine, with further additions from glycine and
methionine. Optimal levels of muscle Cr and PCr may delay the onset
of fatigue during muscle contraction that relies on the ATP-PCr
energy system. Cr supplementation is considered necessary to
increase skeletal muscle’s capacity to generate energy quickly,
thereby enhancing maximal exercise performance. Researchers have
paid little attention to the effect of Cr supplementation on
aerobic endurance performance. Cr supplementation is also
associated with an enhanced cellular anabolic state that may
potentially prevent or lessen muscle atrophy associated with
high-mileage training in ultradistance runners.
The aim of this
research was to investigate the ergogenic effects and safety of Cr
supplementation over the short-, moderate-, and long term. For this
purpose two population groups of interest were identified, namely
well-trained male ultradistance runners and highly active male
university students.
Seventeen well-trained male ultradistance
runners were paired and then, in a double-blind fashion, assigned
to either a group consuming Cr monohydrate (CRE group; 38 ± 7.8
yrs; n = 9) or a group consuming placebo (PLA group; 37 ± 8.2 yrs;
n = 8). Participants ingested 6 g/day supplement for six days.
After post-test 1 (on day 7), the maintenance dosage was ingested
at 3 g/day for 9 weeks. Participants adhered to an
individually-tailored, high-intensity, high-volume sport-specific
training programme.
Advisors/Committee Members: Kruger, P.E. (Pieter Ernst) (advisor).
Subjects/Keywords: Creatine
monohydrate;
UCTD
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APA (6th Edition):
Rossouw, F. (2013). Safety and
effect of creatine monohydrate supplementation. (Doctoral Dissertation). University of Pretoria. Retrieved from http://hdl.handle.net/2263/32947
Chicago Manual of Style (16th Edition):
Rossouw, France. “Safety and
effect of creatine monohydrate supplementation.” 2013. Doctoral Dissertation, University of Pretoria. Accessed March 04, 2021.
http://hdl.handle.net/2263/32947.
MLA Handbook (7th Edition):
Rossouw, France. “Safety and
effect of creatine monohydrate supplementation.” 2013. Web. 04 Mar 2021.
Vancouver:
Rossouw F. Safety and
effect of creatine monohydrate supplementation. [Internet] [Doctoral dissertation]. University of Pretoria; 2013. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/2263/32947.
Council of Science Editors:
Rossouw F. Safety and
effect of creatine monohydrate supplementation. [Doctoral Dissertation]. University of Pretoria; 2013. Available from: http://hdl.handle.net/2263/32947
University of Adelaide
13.
Narayan, Daniel Sanju.
Manipulation of photoreceptor energy metabolism for clinical advantage.
Degree: 2018, University of Adelaide
URL: http://hdl.handle.net/2440/122058
► Photoreceptors are metabolically active cells that account for the majority of the energy consumption in the retina. Photoreceptors also display high rates of aerobic glycolysis…
(more)
▼ Photoreceptors are metabolically active cells that account for the majority of the energy consumption in the retina. Photoreceptors also display high rates of aerobic glycolysis which is unusual in non-proliferating cells. Many diseases of the retina involve degeneration of photoreceptors. Retinitis pigmentosa is the most commonly encountered hereditary retinal dystrophy, featuring degeneration of rod photoreceptors followed by cone photoreceptors. The genetic mutations in retinitis pigmentosa are exclusively expressed in rods, and the secondary death of cones likely involves a component of energy failure. The overriding premise of this thesis was to further our understanding of photoreceptor energy metabolism, then manipulate photoreceptor energy metabolism for clinical advantage using an in vivo model of retinitis pigmentosa. The current thesis comprises three main experiments. In the first experiment, we investigated the role of glucose in the mouse retina and sought to provide an explanation for the high rate of aerobic glycolysis. This was performed by observing the distribution of carbon-14 glucose in the mouse retina using autoradiographic methods. In the second experiment, we characterized the temporal and spatial distribution of cone degeneration in a mouse model of retinitis pigmentosa. Cone quantification was performed using immunohistochemistry and reverse transcription polymerase chain reaction. In the third experiment, we tested two novel bio-energetic agents on the previously characterized mouse model of retinitis pigmentosa. Mice received either systemic
creatine, delivered orally, or local glucose, delivered via repeated subconjunctival injection, and the effect on cone survival was measured using immunohistochemistry and neuro-behavioral responses. The results revealed that local glucose injections had no protective effect on cone survival. However, oral
creatine treatment preserved cones and improved neuro-behavioral responses in retinal degeneration mice. Therefore, we demonstrated that cone degeneration in retinitis pigmentosa likely occurs due to a mechanism that involves, at least in part, energy failure. Bio-energetic treatments, such as
creatine, may play a role as future therapies for retinitis pigmentosa. Further studies will be performed to elucidate the precise mechanisms through which
creatine exerts its protective effects, prior to developing a pathway to clinical translation in human patients.
Advisors/Committee Members: Casson, Robert (advisor), Chidlow, Glyn (advisor), Wood, John (advisor), Adelaide Medical School (school).
Subjects/Keywords: Ophthalmology; retina; photoreceptor; energy metabolism; glucose; creatine
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APA (6th Edition):
Narayan, D. S. (2018). Manipulation of photoreceptor energy metabolism for clinical advantage. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/122058
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Narayan, Daniel Sanju. “Manipulation of photoreceptor energy metabolism for clinical advantage.” 2018. Thesis, University of Adelaide. Accessed March 04, 2021.
http://hdl.handle.net/2440/122058.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Narayan, Daniel Sanju. “Manipulation of photoreceptor energy metabolism for clinical advantage.” 2018. Web. 04 Mar 2021.
Vancouver:
Narayan DS. Manipulation of photoreceptor energy metabolism for clinical advantage. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/2440/122058.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Narayan DS. Manipulation of photoreceptor energy metabolism for clinical advantage. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/122058
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
14.
Abyat, Zahra.
Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice.
Degree: Biomedical Engineering, 2019, University of Manitoba
URL: http://hdl.handle.net/1993/34395
► The creatine/phosphocreatine system, regulated by Creatine kinase, plays a vital role in maintaining energy balance in the brain. Energy metabolism and the function of creatine…
(more)
▼ The
creatine/phosphocreatine system, regulated by
Creatine kinase, plays a vital role in maintaining energy balance in the brain. Energy metabolism and the function of
creatine kinase are known to be affected in Alzheimer’s diseased brain and cells exposed to the amyloid peptide. In Alzheimer’s disease (AD), the brain and cells that contain amyloid peptide deposits show dysfunctional energy metabolism and impaired
creatine kinase activity.
Creatine kinase is an important regulator of the
creatine/phosphocreatine system that keeps the energy balance in these tissues. Therefore, we hypothesize that an enriched
creatine diet provides neuroprotection in early, preclinical AD. Previous publications from our lab indicate increased
creatine levels in brain tissue of AD mice. Given that hypo-metabolism likely precedes neurodegeneration and plaque formation, use of
creatine to target hypo-metabolism could be a promising approach for altering or decelerating the onset of AD. Infrared spectrochemical imaging was used to examine hippocampal, cortical, and cerebellum tissue from 9-month-old mice expressing triple mutations of PSIM146V, APPSwe and tauP301L transgenes, that progressively develop plaques and tangles. These transgenic mice were used to evaluate the effect of
creatine diet (3% w/w) on the development of neurodegeneration. A total of 12 mice (n = 6 background & n = 6 transgenic) were used in this study. These animals were each divided into two groups (n = 3) to be fed regular or
creatine-enriched diets.
Creatine deposits suggestive of altered energetic status were detected by infrared spectrochemical imaging in all the animals. However, the
creatine appearance and crystal morphology was affected by the freeze-thaw procedure involved in sample preparation. Long-term freeze storage also affected
creatine crystallization as indicated by a series of freeze storage and freeze-thaw experiments.
Creatine crystals can get washed away or migrate from tissue surface during the freeze-thaw procedure as
creatine is highly soluble in water. Freeze-thaw experiments confirmed that the sample preparation methods, i.e., methods of tissue acquisition, freezing, storage, and transport affect the formation of the crystals.
Advisors/Committee Members: Gough, Kathleen (Chemistry) (supervisor), Albensi, Benedict C. (Pharmacology and Therapeutics).
Subjects/Keywords: FTIR; 3XTg mouse model; creatine dietary enrichment
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APA (6th Edition):
Abyat, Z. (2019). Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34395
Chicago Manual of Style (16th Edition):
Abyat, Zahra. “Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice.” 2019. Masters Thesis, University of Manitoba. Accessed March 04, 2021.
http://hdl.handle.net/1993/34395.
MLA Handbook (7th Edition):
Abyat, Zahra. “Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice.” 2019. Web. 04 Mar 2021.
Vancouver:
Abyat Z. Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice. [Internet] [Masters thesis]. University of Manitoba; 2019. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/1993/34395.
Council of Science Editors:
Abyat Z. Method optimization for Fourier transform infrared imaging of hippocampal sections from background and 3xTg (AD model) mice. [Masters Thesis]. University of Manitoba; 2019. Available from: http://hdl.handle.net/1993/34395
University of North Carolina – Greensboro
15.
Farah, Shatha I.
Creatine as a neuroprotective agent in manganese-induced
neurotoxicity.
Degree: 2011, University of North Carolina – Greensboro
URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8117
► Manganese (Mn) is a trace metal that is essential for optimal functioning of mammalian systems. However, excessive exposure to Mn is known to cause an…
(more)
▼ Manganese (Mn) is a trace metal that is essential for
optimal functioning of mammalian systems. However, excessive
exposure to Mn is known to cause an extrapyramidal disease.
Presently, Mn-induced neurotoxicity has no cure. In these studies,
we examined the effectiveness of
creatine therapy on models of Mn
neurotoxicity. Primary astrocytes were cultured and divided into
five groups: controls (CN), Mn group (300 μM MnCl2 for 24
hour),
creatine group (1 mM
creatine monohydrate for 24 hour), Mn
followed by
creatine treatment group (MnCr), and
creatine treatment
followed by Mn exposure group (CrMn). Results showed a significant
increase in Mn concentrations in Mn and CrMn groups (p < 0.05),
with Mn group showing a significant decrease in cellular viability
and
creatine attenuating the toxic effects of Mn in the MnCr and
CrMn groups. A significant elevation in glutamate-aspartate
transporter gene expression was seen in CrMn compared to CN, and
glutathione peroxidase (GPx) gene expression was significantly
decreased in MnCr and CrMn groups. Based on this study, we
concluded that
creatine may have some sort of neuroprotection in
Mn-exposed primary cultured astrocytes. Following the astrocyte
study, four brain regions from male Sprague-Dawley rats exposed to
1 g MnCl2 /L in water (Mn; n=6), given intraperitoneal injections
of 75 g/kg body weight monohydrate
creatine (Cr; n=6), or exposed
to Mn and
creatine injections (MnCr; n=6), or received no
creatine
injection with no exposure to Mn (CN; n=6) were dissected and
processed. The effect of waterborne exposure to Mn and
creatine
treatment on gene expression profiles showed a statistical trend
for an increase in glutamate-transporter-1 gene expression in MnCr
group in the globus pallidus (GP) (p=0.066) and caudate-putamen
(CP) (p=0.052) when compared to CN. A statistical trend for
increased GPx gene expression was observed in Cr group of the
substania nigra (SN) (p= 0.055) and MnCr group of cortex (CX)
(p=0.051). Heme oxygenase-1 (HMX-1) in the Mn group of SN showed a
statistical trend for increased gene expression (p= 0.072) when
compared to CN, and GP showed a statistical trend towards an
increased HMX-1 expression in Mn group (p = 0.08) when compared to
MnCr group. Finally, brain cytosolic
creatine kinase gene
expression was significantly lowered in the MnCr group of SN when
compared to CN. Our study suggests that subchronic waterborne
exposure to Mn does not cause significant changes on markers of
oxidative stress and
creatine treatment exerts some neuroprotection
overall.;
Creatine, Manganese, Neuroprotection, Neuroprotective,
Neurotoxicity, Parkinson
Advisors/Committee Members: Keith Erikson (advisor).
Subjects/Keywords: Creatine – Therapeutic use – Effectiveness; Manganese – Toxicology
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APA (6th Edition):
Farah, S. I. (2011). Creatine as a neuroprotective agent in manganese-induced
neurotoxicity. (Masters Thesis). University of North Carolina – Greensboro. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8117
Chicago Manual of Style (16th Edition):
Farah, Shatha I. “Creatine as a neuroprotective agent in manganese-induced
neurotoxicity.” 2011. Masters Thesis, University of North Carolina – Greensboro. Accessed March 04, 2021.
http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8117.
MLA Handbook (7th Edition):
Farah, Shatha I. “Creatine as a neuroprotective agent in manganese-induced
neurotoxicity.” 2011. Web. 04 Mar 2021.
Vancouver:
Farah SI. Creatine as a neuroprotective agent in manganese-induced
neurotoxicity. [Internet] [Masters thesis]. University of North Carolina – Greensboro; 2011. [cited 2021 Mar 04].
Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8117.
Council of Science Editors:
Farah SI. Creatine as a neuroprotective agent in manganese-induced
neurotoxicity. [Masters Thesis]. University of North Carolina – Greensboro; 2011. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=8117
Virginia Tech
16.
Brenner, Megan Lindsay III.
The effects of creatine supplementation on performance and body composition of female athletes.
Degree: MS, Human Nutrition, Foods, and Exercise, 1997, Virginia Tech
URL: http://hdl.handle.net/10919/36985
► The purpose of this investigation was to determine the effects of five weeks of creatine monohydrate ingestion on body composition, blood metabolite, and muscular performance…
(more)
▼ The purpose of this investigation was to determine the effects of
five weeks of
creatine monohydrate ingestion on body composition,
blood metabolite, and muscular performance measures in 16 female NCAA
Division1 lacrosse players. Subjects were randomly divided into
placebo (P,n=9) and
creatine supplement (C,n=7) groups. The supplement
group was administered 20g/d of
creatine monohydrate in capsule form
for 7 d and 2g/d thereafter for five weeks during which time the
subjects were engaged in a pre-season conditioning program. Pre-and
post-testing consisted of a three-site skinfold analysis, bioelectric
impedence (BIA) measurements, hydrostatic weighing, isokinetic knee
extension muscle endurance test (5 sets of 30 repetitions at 180
degrees/sec.), blood lactate response to the performance test
(pre-test and 3 minutes post-test), a 1RM bench press and 1RM leg
extension test. Pre-,mid-, and post- values of blood parameters (BUN
and GPT) were measured in order to ensure the safety of the subjects.
Data was analyzed using two-way ANOVA with repeated measures, and
values are presented as mean+/-SEM for C and P groups,
respectively. Testing revealed that 1RM bench press significantly
increased in both groups (mean increase both groups: 4.5kg), and the C
group improved significantly more than the P group (6.17+/-1.96 and
2.84+/-1.84 kg ). Percent body fat by skinfold also decreased
significantly in both groups over time (0.52%), and the C group
decreased their body fat significantly more than the P group (1.2+0.92
and +0.29+0.81%). Percent body water by BIA also decreased
significantly in both groups over time (2.0%), and the C group
decreased their percent body water significantly more than the P group
(3.0+/-1.06 and 1.0+/-0.92 %). There was a trend for body fat measured
by hydrostatic weighing to decrease for for both groups over the 5
weeks. Although no significant differences between groups were found
in all other measures, significant time effects across groups were
noted (values are absolute mean increase for both groups) for body
weight (0.49+/-3.2kg), 1RM leg extension (1.36+/-4.1kg), BUN
(0.07+/-0.03mmol/L), total work across 5 bouts of isokinetic knee
extension (283.5+/-387.3Watts), and fat-free mass by skinfold
(0.70+/-1.18kg). These data indicate that a regimen of dietary
creatine supplementation designed to increase total muscle Cr content
significantly improved the 1RM bench press strength, and decreased the
percent body fat as assessed by skinfold and the percent body water as
assessed by BIA of a supplemented group more than a placebo group when
all female subjects are engaged in a common resistance training
program. Furthermore, chronic
creatine supplementation appears to
have no detrimental effect on blood metabolites which indicate kidney
and liver function.
Advisors/Committee Members: Rankin, Janet L. Walberg (committeechair), Sebolt, Don R. (committee member), Cross, Lawrence H. (committee member).
Subjects/Keywords: creatine; female athletes
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APA (6th Edition):
Brenner, M. L. I. (1997). The effects of creatine supplementation on performance and body composition of female athletes. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/36985
Chicago Manual of Style (16th Edition):
Brenner, Megan Lindsay III. “The effects of creatine supplementation on performance and body composition of female athletes.” 1997. Masters Thesis, Virginia Tech. Accessed March 04, 2021.
http://hdl.handle.net/10919/36985.
MLA Handbook (7th Edition):
Brenner, Megan Lindsay III. “The effects of creatine supplementation on performance and body composition of female athletes.” 1997. Web. 04 Mar 2021.
Vancouver:
Brenner MLI. The effects of creatine supplementation on performance and body composition of female athletes. [Internet] [Masters thesis]. Virginia Tech; 1997. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10919/36985.
Council of Science Editors:
Brenner MLI. The effects of creatine supplementation on performance and body composition of female athletes. [Masters Thesis]. Virginia Tech; 1997. Available from: http://hdl.handle.net/10919/36985
Virginia Tech
17.
DiLorenzo, Frank Michael.
The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout.
Degree: MS, Human Nutrition, Foods, and Exercise, 2012, Virginia Tech
URL: http://hdl.handle.net/10919/43760
► Aim: The purpose of this study was to investigate the influence of docosahexaenoic acid (DHA) on muscle damage and inflammation following an acute eccentric exercise…
(more)
▼ Aim: The purpose of this study was to investigate the influence of docosahexaenoic acid (DHA) on muscle damage and inflammation following an acute eccentric exercise bout. Methods: A double-blind placebo-controlled, study was performed using 41 healthy, untrained males aged 18-28 y who consumed either 2 g/d DHA or placebo (PL, corn oil) for 32 days. Supplements were consumed for 28 days prior to exercise. Participants completed an eccentric exercise procedure of the elbow flexors at 140% of 1-RM (6 sets x 10 repetitions). The time under tension (TUT) for each set of eccentric contractions was recorded manually from the investigators voice commands. Fasted blood samples for prostaglandin E2 (PGE2), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL1-ra), C-reactive protein and
creatine kinase (CK) were assessed on days 1, 2 and 4. Fasted serum DHA was measured at baseline (day -28) and on day 1. Peak isometric strength of the elbow flexors, delayed-onset muscle soreness, and range of motion were measured on day 1 prior to exercise and days 2, 3, and 4 following exercise. Results: DHA significantly reduced natural log of CK (p<0.05) response over 4 d. Additionally, IL-6 area under the curve (AUC) was reduced for DHA compared to PL (3.6 ± 2.5 pg/mL vs. 5.3 ± 2.7 pg/mL) (p<0.05). TUT/set was higher in the DHA group compared to placebo (p<0.05). There were no other significant differences between treatments. Conclusion: DHA supplementation produced lower indicators of muscle damage (CK) and inflammation (IL-6 AUC). DHA supplementation resulted in greater TUT/set.
Advisors/Committee Members: Rankin, Janet L. Walberg (committeechair), Grange, Robert W. (committee member), Newton, William E. (committee member).
Subjects/Keywords: IL-6; DOMS; DHA; Creatine Kinase
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APA (6th Edition):
DiLorenzo, F. M. (2012). The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/43760
Chicago Manual of Style (16th Edition):
DiLorenzo, Frank Michael. “The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout.” 2012. Masters Thesis, Virginia Tech. Accessed March 04, 2021.
http://hdl.handle.net/10919/43760.
MLA Handbook (7th Edition):
DiLorenzo, Frank Michael. “The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout.” 2012. Web. 04 Mar 2021.
Vancouver:
DiLorenzo FM. The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout. [Internet] [Masters thesis]. Virginia Tech; 2012. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10919/43760.
Council of Science Editors:
DiLorenzo FM. The Effects of Dha Supplementation on Markers of Inflammation and Muscle Damage Following an Acute Eccentric Exercise Bout. [Masters Thesis]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/43760
Michigan State University
18.
Shields, Robert Pierce, 1932-.
The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats.
Degree: PhD, Department of Pathology, 1972, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:19020
Subjects/Keywords: Creatine; Rats – Physiology
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APA (6th Edition):
Shields, Robert Pierce, 1. (1972). The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:19020
Chicago Manual of Style (16th Edition):
Shields, Robert Pierce, 1932-. “The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats.” 1972. Doctoral Dissertation, Michigan State University. Accessed March 04, 2021.
http://etd.lib.msu.edu/islandora/object/etd:19020.
MLA Handbook (7th Edition):
Shields, Robert Pierce, 1932-. “The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats.” 1972. Web. 04 Mar 2021.
Vancouver:
Shields, Robert Pierce 1. The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats. [Internet] [Doctoral dissertation]. Michigan State University; 1972. [cited 2021 Mar 04].
Available from: http://etd.lib.msu.edu/islandora/object/etd:19020.
Council of Science Editors:
Shields, Robert Pierce 1. The effects of feeding B-guanidinoproprionic acid on creatine metabolism and skeletal muscle function and structure of rats. [Doctoral Dissertation]. Michigan State University; 1972. Available from: http://etd.lib.msu.edu/islandora/object/etd:19020
The Ohio State University
19.
Kim, Sangsin.
The histochemistry of creatine kinase.
Degree: PhD, Graduate School, 1972, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486735029378093
Subjects/Keywords: Health Sciences; Creatine
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APA (6th Edition):
Kim, S. (1972). The histochemistry of creatine kinase. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486735029378093
Chicago Manual of Style (16th Edition):
Kim, Sangsin. “The histochemistry of creatine kinase.” 1972. Doctoral Dissertation, The Ohio State University. Accessed March 04, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1486735029378093.
MLA Handbook (7th Edition):
Kim, Sangsin. “The histochemistry of creatine kinase.” 1972. Web. 04 Mar 2021.
Vancouver:
Kim S. The histochemistry of creatine kinase. [Internet] [Doctoral dissertation]. The Ohio State University; 1972. [cited 2021 Mar 04].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486735029378093.
Council of Science Editors:
Kim S. The histochemistry of creatine kinase. [Doctoral Dissertation]. The Ohio State University; 1972. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486735029378093
University of Cincinnati
20.
Abdulla, Zuhair I.
Evaluating a lack of creatine in the monoaminergic
neurotransmitter system.
Degree: PhD, Medicine: Neuroscience/Medical Science Scholars
Interdisciplinary, 2019, University of Cincinnati
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573225385280837
► The creatine (Cr)/phosphoCr (PCr) shuttle acts as an ATP buffer for cells with a high energy demand. This shuttle uses Cr kinases to catalyze the…
(more)
▼ The
creatine (Cr)/phosphoCr (PCr) shuttle acts as an
ATP buffer for cells with a high energy demand. This shuttle uses
Cr kinases to catalyze the conversion of ADP to ATP using the
phosphate group from PCr. Cr’s buffering capacity decreases
reliance on slow energy generating processes by maintaining ATP
levels. Its importance to neurological function is made clear by
cerebral
creatine deficiency syndromes (CCDS), disorders caused by
an absence of Cr. The primary symptoms of CCDS are neurological,
the most prominent being intellectual disability (ID). Cr
transporter (Crt) deficiency (CTD) is the most common CCDS, itself
accountable for ~2% of all X-linked ID. CTD is caused by mutations
in SLC6A8, rendering the Crt dysfunctional, resulting in an absence
of brain Cr. Approximately 50% of patients also have attentional
deficits and/or hyperactivity and motoric impairments are also
observed. It is unknown how the lack of cellular Cr causes this
disorder. Crt knockout mice (Slc6a8-/y) have cognitive deficits,
lack brain Cr, and are a high-fidelity model of CTD. Slc6a8-/y mice
have spatial learning and memory, object recognition, and fear
memory deficits. Aside from the phenotype of CCDSs, little else is
known about brain Cr function. This dissertation aims to further
characterize the behavioral effects of Cr deficiency. Decreased
brain Cr concentrations are observed in several psychiatric
disorders, including depression, schizophrenia, and anxiety. In
rats and mice, Cr increased coping behaviors in the forced-swim
test and the tail-suspension test (TST). As an adjunct to
serotonergic antidepressants in humans, Cr improves depressive
symptoms faster and to a greater degree than antidepressants alone.
Relatedly, Slc6a8-/y mice have increased 5-hydroxyindoleacetic acid
and serotonin (5-HT), indicating an abnormal serotonergic system.
These data suggest that Slc6a8-/y mice would have an altered
affective phenotype. Slc6a8-/y and female mice heterozygous for
Slc6a8 mutation (Slc6a8+/-) were tested in elevated zero maze
(EZM), TST, and learned helplessness. EZM and TST performance did
not differ from wild type controls, but Slc6a8-/y and Slc6a8+/-
mice were resilient to learned helplessness, indicating that Cr may
be important in induced-depressive like behaviors. Brain Cr
reductions are also common in motor disorders tied to dopaminergic
impairment. Cr protects against toxins used to model motor
impairments in rodents. To assess Cr’s role in motor activity, we
created mice lacking Crt in dopamine neurons (dCrt-/y). Motor
ability was assessed monthly from postnatal day (P) 90 until P360
in dCrt-/y mice using the challenging beam, spontaneous activity,
and overnight locomotor assays. While no motor deficits emerged,
dCrt-/y mice are persistently hyperactive. Finally, it is unknown
why Cr deficiencies cause cognitive deficits. Slc6a8-/y mice have
serotonergic abnormalities, and 5-HT is involved in cognition.
Serotonergic drugs (i.e. MDMA and citalopram) causes lasting
cognitive deficits in developing rats. Serotonergic…
Advisors/Committee Members: Gross, Christina (Committee Chair).
Subjects/Keywords: Neurology; Creatine; Monomamines; Dopamine; Serotonin; Affect; energy
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APA (6th Edition):
Abdulla, Z. I. (2019). Evaluating a lack of creatine in the monoaminergic
neurotransmitter system. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573225385280837
Chicago Manual of Style (16th Edition):
Abdulla, Zuhair I. “Evaluating a lack of creatine in the monoaminergic
neurotransmitter system.” 2019. Doctoral Dissertation, University of Cincinnati. Accessed March 04, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573225385280837.
MLA Handbook (7th Edition):
Abdulla, Zuhair I. “Evaluating a lack of creatine in the monoaminergic
neurotransmitter system.” 2019. Web. 04 Mar 2021.
Vancouver:
Abdulla ZI. Evaluating a lack of creatine in the monoaminergic
neurotransmitter system. [Internet] [Doctoral dissertation]. University of Cincinnati; 2019. [cited 2021 Mar 04].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573225385280837.
Council of Science Editors:
Abdulla ZI. Evaluating a lack of creatine in the monoaminergic
neurotransmitter system. [Doctoral Dissertation]. University of Cincinnati; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573225385280837
21.
Almeida, L.S.
Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes.
Degree: 2006, NARCIS
URL: https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d
;
urn:nbn:nl:ui:31-1871/10848
;
c8727583-5a04-4e24-952c-99f5e1e2dc4d
;
1871/10848
;
urn:isbn:9086590438
;
urn:nbn:nl:ui:31-1871/10848
;
https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d
Subjects/Keywords: creatine; diagnosis; syndromes
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APA (6th Edition):
Almeida, L. S. (2006). Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d ; urn:nbn:nl:ui:31-1871/10848 ; c8727583-5a04-4e24-952c-99f5e1e2dc4d ; 1871/10848 ; urn:isbn:9086590438 ; urn:nbn:nl:ui:31-1871/10848 ; https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d
Chicago Manual of Style (16th Edition):
Almeida, L S. “Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes.” 2006. Doctoral Dissertation, NARCIS. Accessed March 04, 2021.
https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d ; urn:nbn:nl:ui:31-1871/10848 ; c8727583-5a04-4e24-952c-99f5e1e2dc4d ; 1871/10848 ; urn:isbn:9086590438 ; urn:nbn:nl:ui:31-1871/10848 ; https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d.
MLA Handbook (7th Edition):
Almeida, L S. “Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes.” 2006. Web. 04 Mar 2021.
Vancouver:
Almeida LS. Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes. [Internet] [Doctoral dissertation]. NARCIS; 2006. [cited 2021 Mar 04].
Available from: https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d ; urn:nbn:nl:ui:31-1871/10848 ; c8727583-5a04-4e24-952c-99f5e1e2dc4d ; 1871/10848 ; urn:isbn:9086590438 ; urn:nbn:nl:ui:31-1871/10848 ; https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d.
Council of Science Editors:
Almeida LS. Molecular and Biochemical Diagnosis of Cerebral Creatine Deficiency Syndromes. [Doctoral Dissertation]. NARCIS; 2006. Available from: https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d ; urn:nbn:nl:ui:31-1871/10848 ; c8727583-5a04-4e24-952c-99f5e1e2dc4d ; 1871/10848 ; urn:isbn:9086590438 ; urn:nbn:nl:ui:31-1871/10848 ; https://research.vu.nl/en/publications/c8727583-5a04-4e24-952c-99f5e1e2dc4d
22.
Ferreira, Lucas Guimarães.
Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos.
Degree: Mestrado, Fisiologia Humana, 2008, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-150716/
;
► A creatina (Cr) é uma reserva de fosfato de alta energia, sendo a fonte mais rápida de restauração do ATP intracelular. O hormônios tireoideano participa…
(more)
▼ A creatina (Cr) é uma reserva de fosfato de alta energia, sendo a fonte mais rápida de restauração do ATP intracelular. O hormônios tireoideano participa de forma importante na manutenção da taxa metabólica, aumentando a síntese e consumo de ATP, por meio da regulação de diferentes genes-alvo. Neste sentido, avaliamos o efeitos do HT sobre a expressão gênica do transportador de Cr nos músculos esqueléticos e cardíaco de ratos. O tratamento com o hormônio regula estes processos, porém de forma distinta nos diferentes tipos de músculos.
Creatine (Cr) is a high-energy phosphate reservoir and the fastest source for intracellular ATP regeneration. The thyroid hormone plays a key role on the maintenance of basal metabolic rate, increasing the synthesis and the degradation of ATP through regulation of target-genes. In this study, we explore the effects of thyroid hormone on Cr transporter gene expression and regulation of intracellular pool of Cr in skeletal and cardiac muscles in rats. The hormone can regulate these processes in distinct ways in different muscle types.
Advisors/Committee Members: Nunes, Maria Tereza.
Subjects/Keywords: Cardiac muscle; Creatina; Creatine; Creatine transporter; Hormônios tireoideanos; Músculo cardíaco; Músculo esquelético; Skeletal muscle; Thyroid hormones; Transportador de creatina
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APA (6th Edition):
Ferreira, L. G. (2008). Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-150716/ ;
Chicago Manual of Style (16th Edition):
Ferreira, Lucas Guimarães. “Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos.” 2008. Masters Thesis, University of São Paulo. Accessed March 04, 2021.
http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-150716/ ;.
MLA Handbook (7th Edition):
Ferreira, Lucas Guimarães. “Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos.” 2008. Web. 04 Mar 2021.
Vancouver:
Ferreira LG. Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 04].
Available from: http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-150716/ ;.
Council of Science Editors:
Ferreira LG. Efeito do hormônio tireoideano sobre a expressão gênica do transportador de creatina (SLC6A8: CreaT) na musculatura esquelética e cardíaca de ratos. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-150716/ ;
University of Cape Town
23.
Shapiro, B G.
Studies in the physiology of creatine and creatinine.
Degree: Doctoral, Division of Physiological Sciences, 1935, University of Cape Town
URL: http://hdl.handle.net/11427/31872
► The studies recorded in this thesis cover a wide portion of the field of creatine-creatinine metabolism. They involve a consideration of the problem of the…
(more)
▼ The studies recorded in this thesis cover a wide portion of the field of creatine-creatinine metabolism. They involve a consideration of the problem of the origin of creatine, of the endocrine factors controlling its metabolism, and of the function of creatine and creatinine in the body. In order to obtain a true perspective of the place of these investigations in relation to the physiology of creatine as a whole, it is first necessary to review briefly what is known of the metabolism
and function of the two substances. And, in view of the light they throw on these questions, consideration
must also be given to the chemical constitution and distribution of creatine and creatinine.
Subjects/Keywords: creatinine; physiology of creatine; creatine-creatinine metabolism
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APA (6th Edition):
Shapiro, B. G. (1935). Studies in the physiology of creatine and creatinine. (Doctoral Dissertation). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31872
Chicago Manual of Style (16th Edition):
Shapiro, B G. “Studies in the physiology of creatine and creatinine.” 1935. Doctoral Dissertation, University of Cape Town. Accessed March 04, 2021.
http://hdl.handle.net/11427/31872.
MLA Handbook (7th Edition):
Shapiro, B G. “Studies in the physiology of creatine and creatinine.” 1935. Web. 04 Mar 2021.
Vancouver:
Shapiro BG. Studies in the physiology of creatine and creatinine. [Internet] [Doctoral dissertation]. University of Cape Town; 1935. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/11427/31872.
Council of Science Editors:
Shapiro BG. Studies in the physiology of creatine and creatinine. [Doctoral Dissertation]. University of Cape Town; 1935. Available from: http://hdl.handle.net/11427/31872
24.
松尾, 尚志.
心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について.
Degree: 博士(医学), 医学, 1991, Hokkaido University
URL: http://hdl.handle.net/2115/51147
creatine kinase（CK）系は細胞内で高エネルギー燐酸の運搬に関与している。ミトコンドリアで産生されたATPはミトコンドリアCKによりcreatine燐酸に変えられエネルギー消費系である細胞質内へ運搬される。ミトコンドリアCKの異常はATP輸送障害をひきおこし、細胞質内でATPの減少をもたらす。このことが心機能障害につながることが推測される。今回、われわれは心筋症ハムスター（BIO14.6，BIO53.58）の心室筋を用い、BIO14.6では第5，20，50，62週齢で、BIO53.58では第5，20週齢でcreatine kinaseシステムを検討した。その結果、肥大型心筋症モデルであるBIO14.6では第20週齢からミトコンドリア分画CK活性の低下が存在し、第50週齢以後ではcytoplasmic CKのCK-BBへのシフトが認められた。また、拡張型心筋症モデルであるBIO53.58では、生後早期からミトコンドリアCK活性の異常とcytoplasmic CKのCK-BBへのシフトが認められた。このように、心筋症ハムスターではミトコンドリアCKの異常が存在し、細胞内高エネルギー燐酸輸送が障害されていると考えられた。これが、心筋症ハムスターの心機能障害をおこす一因と推定された。
Subjects/Keywords: Mitochondrial creatine kinase Cardiomyopathy; Creatine kinase; Hamster
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APA (6th Edition):
松尾, . (1991). 心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について. (Doctoral Dissertation). Hokkaido University. Retrieved from http://hdl.handle.net/2115/51147
Chicago Manual of Style (16th Edition):
松尾, 尚志. “心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について.” 1991. Doctoral Dissertation, Hokkaido University. Accessed March 04, 2021.
http://hdl.handle.net/2115/51147.
MLA Handbook (7th Edition):
松尾, 尚志. “心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について.” 1991. Web. 04 Mar 2021.
Vancouver:
松尾 . 心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について. [Internet] [Doctoral dissertation]. Hokkaido University; 1991. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/2115/51147.
Council of Science Editors:
松尾 . 心筋症ハムスターにおけるミトコンドリア creatine kinase 活性の異常について. [Doctoral Dissertation]. Hokkaido University; 1991. Available from: http://hdl.handle.net/2115/51147
University of Cape Town
25.
Bold, Antoinette.
The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training.
Degree: Image, MRC/UCT RU for Exercise and Sport Medicine, 1996, University of Cape Town
URL: http://hdl.handle.net/11427/26974
► Oral creatine supplementation has been shown to increase skeletal muscle total creatine (TCr) content, and in some cases improve performance in high-intensity short duration exercise.…
(more)
▼ Oral
creatine supplementation has been shown to increase skeletal muscle total
creatine (TCr) content, and in some cases improve performance in high-intensity short duration exercise. A variety of factors related to an enhanced efficacy of adenine nucleotide metabolism have been demonstrated as partly responsible for this ergogenic effect. Also, there is evidence that high-intensity sprint training results in a decrease in muscle total adenine nucleotide (TAN) and/or ATP stores. This placebo controlled double-blind study examined whether an oral
creatine supplementation regimen would 1) increase muscle TCr content, 2) attenuate any loss in TAN or ATP during intermittent sprint training, and 3) have an ergogenic effect on performance after sprint training. Thirteen male endurance trained cyclists ingested 20 g of
creatine monohydrate supplement or placebo per day for 7 days, after which they ingested a maintenance dose of 2 g
creatine or placebo per day for the remainder of the trial (15d). While on the maintenance dose, subjects performed intermittent sprint training (ST) on a cycle ergometer (10 x 10 s sprints with 140 s active recovery) for 6 consecutive days and a 7th day after one day of rest. Performance tests were performed before and after ST, and metabolic tests were performed on the 1st and 7th day of ST. TCr increased significantly with
creatine supplementation (
creatine group pre: 121 ± 4, post: 147 ± 9; vs. placebo group pre: 122 ± 4, post: 125 ± 4 mmol/kg dm; mean± SEM; p<0.05). The increase in TCr correlated with the percentage Type IIB fibres (r=0.95, p<0.005). By day 7 of ST, TCr content was no longer significantly higher than pre-supplementation levels despite the maintenance dose of
creatine. ST resulted in a significant decrease in resting muscle TAN and ATP content in both groups (ATP content in
creatine group pre: 24.1 ± 0.8, post: 17.2 ± 0.5; and placebo group pre: 26.5 ± 1.1, post: 18.0 ± 0.6 mmol/kg dm; p<0.001). During and in recovery from ST on day 7, both groups had lower plasma ammonia (p<0.05), hypoxanthine (p<0.001) and urate (p<0.001) accumulation than on day 1 of ST. There was no improvement in 1-hr cycle distance performance after ST, but peak sustained power output increased in the
creatine group and not in the placebo group after ST (p<0.05). Peak and mean power during a 30 s Wingate test increased significantly (p<0.05) after ST but there was no additional ergogenic effect of
creatine supplementation. In conclusion, this study shows that 1) the efficacy of muscle
creatine uptake was dependent on the percentage of Type IIB fibres, 2)
creatine supplementation and maintenance (2 g/d) did not attenuate ATP or TAN loss during 7 days of ST, 3) ST decreased the accumulation of plasma products of adenine nucleotide degradation and improved 30 s sprint performance, and 4)
creatine supplementation and ST did not improve I-hr cycle distance performance.
Advisors/Committee Members: Myburgh, Kathryn Helen (advisor).
Subjects/Keywords: Exercise Science; Creatine; Creatine - metabolism; Exertion - physiology
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APA (6th Edition):
Bold, A. (1996). The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/26974
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bold, Antoinette. “The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training.” 1996. Thesis, University of Cape Town. Accessed March 04, 2021.
http://hdl.handle.net/11427/26974.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bold, Antoinette. “The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training.” 1996. Web. 04 Mar 2021.
Vancouver:
Bold A. The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training. [Internet] [Thesis]. University of Cape Town; 1996. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/11427/26974.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bold A. The effects of prior oral creatine supplementation on performance and metabolism after 7 days of sprint cycle training. [Thesis]. University of Cape Town; 1996. Available from: http://hdl.handle.net/11427/26974
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
Riesberg, Lisa A.
The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant.
Degree: PhD, Medical Microbiology and Immunology (graduate program), 2017, Creighton University
URL: http://hdl.handle.net/10504/112907
► Creatine (CR) is an ergogenic agent used to enhance anaerobic exercise performance by increasing phosphocreatine stores and free CR to increase adenosine triphosphate (ATP) turnover…
(more)
▼ Creatine (CR) is an ergogenic agent used to enhance anaerobic exercise performance by increasing phosphocreatine stores and free CR to increase adenosine triphosphate (ATP) turnover in the muscles, therefore increasing muscle mass and reducing muscle recovery time following a strenuous workout. CR hydrolyzes into creatinine (CRN) rapidly. Previous work from the laboratory has shown in vitro that CRN has some immunomodulatory properties. To further delineate the immunomodulatory properties of CRN, we used real time-polymerase chain reaction and immunohistochemical staining to determine the mRNA and protein expression of tumor necrosis factor-α (TNF-α), a potent pro-inflammatory mediator, following exposure to CRN in mouse and human macrophages and human T cells. These studies demonstrated a significant reduction in TNF-α mRNA and protein in CRN-treated cells compared to control-treated cells. The majority of TNF-α is generated by the nucelar factor-kappa B pathway (NF-κB), the translocation of the p65 subunit of NF-κB was reduced in CRN-treated cells. We extended these studies in vivo using human subjects. A double-blind study was performed using CR monohydrate and placebo. Subjects consumed the supplement in a manner consistent with standard loading (4 x 5 g for 5 d) and maintenance (5 g for 28 d) regimens. Blood was collected at the end of the loading and maintenance periods as well as prior to supplementation. Analysis of TNF-α mRNA levels revealed that subjects supplementing with CR had reduced levels of TNF-α mRNA in their white blood cells compared to placebo supplemented subjects after the loading phase. Given the results of the in vitro study and the fast hydrolysis of CR to CRN, we postulate that the observed results in vivo are attributed to the increased CRN levels in the CR-supplemented subjects. Finally, the antioxidant properties of CRN were assessed in mouse macrophages against three oxidative agents – hydrogen peroxide, tert-butyl hydroperoxide (tert-BuOOH), and 3-morpholinosydnonimine chloride (SIN-1). CRN was observed to provide cellular protection against cell death mediated by hydrogen peroxide and SIN-1, but not tert-BuOOH. Together, these data suggest that both CR and CRN act as immune modulators by inhibiting pro-inflammatory cytokine TNF-α, and it has been hypothesized that CR supplementation may decrease the ability of the host to respond rapidly to pathogens due to increased CRN levels. Furthermore, the data suggest that many of the properties attributed to CR may actually be due the effects of CRN. The anti-inflammatory and antioxidant qualities of CRN provide novel potential therapeutic roles for CRN which is largely thought to be a waste product.
Advisors/Committee Members: Drescher, Kristen M. (advisor), Riesberg, Lisa A. (cuauthor).
Subjects/Keywords: Creatine – pharmacology.; Muscle Strength – drug effects; Anti-Inflammatory Agents – pharmacology
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APA (6th Edition):
Riesberg, L. A. (2017). The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant. (Doctoral Dissertation). Creighton University. Retrieved from http://hdl.handle.net/10504/112907
Chicago Manual of Style (16th Edition):
Riesberg, Lisa A. “The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant.” 2017. Doctoral Dissertation, Creighton University. Accessed March 04, 2021.
http://hdl.handle.net/10504/112907.
MLA Handbook (7th Edition):
Riesberg, Lisa A. “The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant.” 2017. Web. 04 Mar 2021.
Vancouver:
Riesberg LA. The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant. [Internet] [Doctoral dissertation]. Creighton University; 2017. [cited 2021 Mar 04].
Available from: http://hdl.handle.net/10504/112907.
Council of Science Editors:
Riesberg LA. The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant. [Doctoral Dissertation]. Creighton University; 2017. Available from: http://hdl.handle.net/10504/112907
27.
Funari, Sabrina.
Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro.
Degree: Mestrado, Nutrição e Produção Animal, 2011, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29082012-160647/
;
► O exercício de enduro é caracterizado por um esforço aeróbico prolongado, de intensidade variável em que o cavalo é submetido a um trabalho permanente o…
(more)
▼ O exercício de enduro é caracterizado por um esforço aeróbico prolongado, de intensidade variável em que o cavalo é submetido a um trabalho permanente o qual exige dos sistemas orgânicos a manutenção da homeostasia. A habilidade dos músculos em gerar energia rapidamente via produção de lactato, é essencial para o desempenho em exercícios de elevada intensidade. Entretanto, a produção de lactato pode também suprimir muitos dos processos vitais necessários pra sustentar a atividade muscular. A associação de lactato com a fadiga muscular tem levado à busca de suplementos alimentares que reduzem o acúmulo de lactato. N,N-Dimetilglicina (DMG), um intermediário do metabolismo da colina, é um suplemento atualmente comercializado, porém não há dados consistentes na literatura sobre sua eficácia para equinos atletas. Objetivando avaliar o efeito da DMG, utilizou-se 12 animais em treinamento para provas de enduro, dos quais seis receberam suplementação oral; utilizou-se delineamento inteiramente casualizado, com medidas repetidas no tempo. Foram coletadas amostras de sangue em sete tempos diferentes, a cada 15 dias; dessas amostras obteve-se valores das enzimas creatina quinase e aspartato aminotransferase e também valores de glicose e lactato, além de medições de freqüência cardíaca e respiratória. Após 30 dias da última amostragem, realizaram-se coletas de sangue em intervalos curtos de tempo, após exercício, a fim de se realizar uma curva de lactato, e também comparar dados analisados em laboratório com analisados via lactímetro. Dos dados analisados, houve interação entre tempo e aumento da enzima creatina quinase, o que pode ser justificado pelo aumento da demanda muscular durante exercício físico constante. A enzima aspartato aminotransferase diminuiu com o passar do tempo, em ambos os grupos, porém oscilou dentro da normalidade, o que pode caracterizar baixa permeabilidade da membrana celular, comum em animais condicionados. A alteração da glicose foi a mesma ao longo do tempo para ambos os grupos. As médias de lactato não diferiram no grupo suplementado, mas sua variação dentro do grupo não suplementado sugere que a suplementação com DMG pode influenciar na manutenção da integridade muscular. Em comparação entre as formas de dosagem do lactato plasmático, pode-se concluir que o lactímetro é uma ferramenta eficaz na obtenção de dados a campo, pois suas médias não diferiram das médias de lactato obtidas através de análise laboratorial. A suplementação oral com dimetilglicina não influenciou o desempenho atlético de cavalos em treinamento para enduro equestre.
The exercise endurance is characterized by a prolonged aerobic work, of varying intensity in which the horse is subjected to a permanent job which requires organ systems maintain homeostasis. The ability of muscles to generate energy quickly via production of lactate is essential for the performance of high intensity exercise. However, the production of lactate may also suppress many of the vital processes necessary to sustain muscle activity. The combination of…
Advisors/Committee Members: Gobesso, Alexandre Augusto de Oliveira.
Subjects/Keywords: Creatina; Creatine; Equine; Equino; Exercício; Exercise; Lactate; Lactato
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APA (6th Edition):
Funari, S. (2011). Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29082012-160647/ ;
Chicago Manual of Style (16th Edition):
Funari, Sabrina. “Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro.” 2011. Masters Thesis, University of São Paulo. Accessed March 04, 2021.
http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29082012-160647/ ;.
MLA Handbook (7th Edition):
Funari, Sabrina. “Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro.” 2011. Web. 04 Mar 2021.
Vancouver:
Funari S. Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2021 Mar 04].
Available from: http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29082012-160647/ ;.
Council of Science Editors:
Funari S. Avaliação da suplementação com dimetilglicina sobre o desempenho atlético de cavalos de enduro. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29082012-160647/ ;
28.
Silva, Renato Barroso da.
Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida.
Degree: Mestrado, Biodinâmica do Movimento Humano, 2007, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-14082008-145538/
;
► A realização de uma sessão com ações excêntricas provoca dano na estrutura muscular. Durante o processo de recuperação, essa estrutura sofre adaptações que a protegem…
(more)
▼ A realização de uma sessão com ações excêntricas provoca dano na estrutura muscular. Durante o processo de recuperação, essa estrutura sofre adaptações que a protegem da ocorrência de dano nas sessões subseqüentes. Essas adaptações são chamadas de Efeito da Carga Repetida (ECR). Esse efeito foi estudado com a realização de apenas duas sessões de exercícios. A velocidade da ação excêntrica também pode contribuir para a variabilidade do dano induzido. O objetivo desse estudo foi investigar através da análise dos indicadores indiretos, creatina quinase (CK), força, dor, circunferência e amplitude de movimento (ADM), o dano induzido por diferentes velocidades da ação excêntrica e o efeito da carga repetida com a realização das diferentes velocidades (60ºs-1 (Exc60) e 180ºs-1 (Exc180)); e verificar se o efeito da carga repetida seria maior com a realização de três sessões de exercícios. Os resultados dos indicadores analisados tiveram alterações semelhantes nos grupos Exc60 e Exc180, sugerindo que as diferentes velocidades parecem não interferir na magnitude do dano induzido. O ECR não foi diferente entre as velocidades, pois o comportamento das variáveis analisadas foi semelhante entre os dois grupos nas duas sessões iniciais. A realização da terceira sessão de exercícios excêntricos não promove o aumento do efeito protetor, visto que não houve diferenças significantes entre a segunda e a terceira sessão. Indicando que o ECR advém principalmente da realização da primeira sessão
Performing a bout of eccentric exercise causes muscle damage. During recovery, some adaptations occur that can protect muscle structure. These adaptations are known as Repeated Bout Effect. However, this phenomenon has been studied with two bouts. Velocity of eccentric action has been referred as one possible factor which can affect the extension of muscle damage. The aim of this study was to investigate muscle damage induced by different velocities, the repeated bout effect with different velocities and to verify if the repeated bout effect could be larger if three bouts of eccentric exercise were performed. Results of indirect markers of muscle damage (CK, DOR, upper-arm circumference, maximal isometric force) showed similar alterations in groups Exc60 and Exc180, suggesting that different velocities do not affect the extension of muscle damage. Repeated bout effect is not different between velocities, because changes in markers were comparable in both groups after the first two bouts. After performing a third bout of eccentric exercise, there was not any significant differences between second and third bouts. It indicates that the first bout is responsible for the adaptations of the repeated bout effect
Advisors/Committee Members: Tricoli, Valmor Alberto Augusto.
Subjects/Keywords: Creatina quinase; Creatine kinase; Dano muscular; Eccentric; Excêntrico; Muscle damage
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APA (6th Edition):
Silva, R. B. d. (2007). Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/39/39132/tde-14082008-145538/ ;
Chicago Manual of Style (16th Edition):
Silva, Renato Barroso da. “Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida.” 2007. Masters Thesis, University of São Paulo. Accessed March 04, 2021.
http://www.teses.usp.br/teses/disponiveis/39/39132/tde-14082008-145538/ ;.
MLA Handbook (7th Edition):
Silva, Renato Barroso da. “Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida.” 2007. Web. 04 Mar 2021.
Vancouver:
Silva RBd. Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida. [Internet] [Masters thesis]. University of São Paulo; 2007. [cited 2021 Mar 04].
Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-14082008-145538/ ;.
Council of Science Editors:
Silva RBd. Respostas musculares à realização de ações excêntricas em diferentes velocidades e sua influência no efeito da carga repetida. [Masters Thesis]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-14082008-145538/ ;
Universidade Estadual de Campinas
29.
Jerônimo, Diego Pereira, 1983-.
Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue.
Degree: 2016, Universidade Estadual de Campinas
URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/305350
► Abstract: Although it is widely known the ergogenic effects of creatine as much caffeine we have no sufficient scientific evidence on reconciling the two ergogenic…
(more)
▼ Abstract: Although it is widely known the ergogenic effects of
creatine as much caffeine we have no sufficient scientific evidence on reconciling the two ergogenic on physical performance. Faced with this question the present study investigated the action of
creatine and caffeine supplementation on neuromuscular activation, fatigue and torque. We selected the 16 physically active, healthy subjects aged between 18 and 30 years, the study was performed in two stages (experiment 1) individuals were supplemented with caffeine (6 mg / kg) (Caf) for 3 days,
creatine (3g / day) (Cre 3) for 7 days and combination of caffeine and
creatine (CrCaf) (experiment 2) the participants were supplemented with
creatine (20g / day) (Cr higt) for 7 days, combination of caffeine and
creatine (CrCaf higt) and placebo supplementation (Pla). After the supplementation periods underwent knee extension test in isokinetic dynamometer which was monitored electromyographic (EMG) activity of the muscles. The test protocol consisted of 45 repetitions of extension and knee flexion angle at a constant speed of 1200 / s in isokinetic dynamometer Biodex, Where was monitored torque to the extent of making and the EMG activity of the vastus lateralis (VL), vastus (VM) and rectus femoris (RF). We can observe CrCaf groups and CrCaf Higt a lower activation MUs through the RMS values (p <0.05), which agrees with the values of MDF that had these same groups 5.67% for values less fatigue (p <0.05) and total torque increased 7.47% (p <0.05). Given these results
creatine and caffeine proved association help improve the total torque and delay the onset of fatigue which can directly influence the performance of high-intensity exercise in a variety of sports
Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Moraes, Antonio Carlos de, 1960- (advisor), Universidade Estadual de Campinas. Faculdade de Educação Física (institution), Programa de Pós-Graduação em Educação Física (nameofprogram), Borin, João Paulo (committee member), Altimari, Leandro Ricardo (committee member), Martins, Luiz Eduardo Barreto (committee member), Marques, Martim Francisco Bottaro (committee member).
Subjects/Keywords: Creatina; Cafeína; Suplementos dieteticos; Dinamometro; Creatine; Caffeine; Dietary supplements; Dynamometer
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APA (6th Edition):
Jerônimo, Diego Pereira, 1. (2016). Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/305350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jerônimo, Diego Pereira, 1983-. “Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue.” 2016. Thesis, Universidade Estadual de Campinas. Accessed March 04, 2021.
http://repositorio.unicamp.br/jspui/handle/REPOSIP/305350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jerônimo, Diego Pereira, 1983-. “Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue.” 2016. Web. 04 Mar 2021.
Vancouver:
Jerônimo, Diego Pereira 1. Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Mar 04].
Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/305350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jerônimo, Diego Pereira 1. Influência da suplementação de creatina e cafeina sobre a fadiga neuromuscular: Influence of creatine and caffeine supplementation on neuromuscular fatigue. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/305350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Ricardo Teixeira Goldfeder.
Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo.
Degree: 2010, Universidade do Estado de Santa Catarina
URL: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=1990
► Introdução: A concentração sérica de Creatina Kinase (CK) é importante para o diagnóstico de algumas doenças e avaliação clínica de atletas, mas há contradições na…
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▼ Introdução: A concentração sérica de Creatina Kinase (CK) é importante para o diagnóstico de algumas doenças e avaliação clínica de atletas, mas há contradições na literatura sobre a influência de características individuais nesta concentração. Além disso, os valores de referência podem não ser adequados para atletas Objetivo: Comparar os níveis de CK de triatletas com os valores de referência atuais, e verificar a influência do peso, massa magra, idade, gênero e tempo de esforço na concentração sérica de CK após o exercício Metodologia: Foram convidados a participar do estudo triatletas inscritos nas provas de Ironman, em Florianópolis/SC, de 2003 a 2007. De 2003 a 2006, a amostra foi aleatória, e os atletas tiveram o sangue coletado 2 dias antes da competição e logo após completar a mesma. No ano de 2007, a amostra foi constituída por atletas de uma equipe de Florianópolis/SC, que tiveram o sangue coletado em 5 momentos: 14 dias e 2 dias antes da competição; logo após; 8 e 15 dias depois. Em 2007, além de sangue, foram coletadas as medidas de peso corporal e dobras cutâneas. Não puderam participar do estudo os indivíduos utilizando medicamentos da classe das estatinas. Resultados: Participaram de todas as etapas da pesquisa 96 atletas, sendo 83 do sexo masculino. Estes apresentaram CK antes da prova (CK1) 184 + 104,4 U/L e após a prova (CK2) 2473 + 2181,7 U/L. As mulheres apresentaram CK1 128 + 49,2 U/L e CK2 1728 + 923,7 U/L.Todos os outros marcadores bioquímicos avaliados aumentaram significativamente após a prova: CK-MB, uréia, creatinina, LDH, mioglobina e hematócrito. Na análise de 2007, constatamos que apenas após a prova a CK era diferente entre os 5 momentos de coleta. As análises de correlação mostraram correlação significativa (p<0,05) da CK2 apenas com CK1 e mioglobina pós-prova, e não houve correlação significativa com peso corporal, massa magra, tempo de prova e idade. Conclusão: Os valores de referência para a população não são adequados para a avaliação de triatletas em repouso, e por isso devem ser revistos. A idade, massa magra, peso e tempo de prova não são determinantes nos níveis de CK, e níveis elevados não podem ser justificados por hemoconcentração ou disfunção renal, na maior parte dos atletas. Com relação ao gênero, as mulheres apresentaram níveis mais baixos de CK antes da competição, mas após a competição esta diferença não foi significativa.
Introduction: The serum concentration of creatine kinase (CK) is important for the diagnosis of certain diseases and clinical evaluation of athletes, but there are contradictory studies about the influence of individual characteristics in this concentration. Furthermore, the benchmarks may not be suitable for athletes Objective: To compare the CK levels of triathletes with the current benchmarks, and the influence of weight, lean mass, age, gender and exercise time in serum CK after exercise Methodology: They were invited to participate in the study triathletes entered in Ironman events, Florianópolis / SC, from 2003 to 2007. From 2003 to 2006,…
Advisors/Committee Members: Tales de Carvalho.
Subjects/Keywords: EDUCACAO FISICA; Ironman; triathlon; creatine kinase; Ironman; exercise; creatina kinase; exercício
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APA (6th Edition):
Goldfeder, R. T. (2010). Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo. (Thesis). Universidade do Estado de Santa Catarina. Retrieved from http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=1990
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Goldfeder, Ricardo Teixeira. “Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo.” 2010. Thesis, Universidade do Estado de Santa Catarina. Accessed March 04, 2021.
http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=1990.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Goldfeder, Ricardo Teixeira. “Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo.” 2010. Web. 04 Mar 2021.
Vancouver:
Goldfeder RT. Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo. [Internet] [Thesis]. Universidade do Estado de Santa Catarina; 2010. [cited 2021 Mar 04].
Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=1990.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Goldfeder RT. Comportamento da creatina kinase em participantes de provas de triatlo Ironman; triatlo. [Thesis]. Universidade do Estado de Santa Catarina; 2010. Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=1990
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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