subject:(Cpk )

Universidad de Extremadura

1. Moreno Carbonell, Valentín. Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina .

Degree: 2016, Universidad de Extremadura

URL: http://hdl.handle.net/10662/4767

► Las estatinas actualmente constituyen un pilar fundamental en el tratamiento hipolipemiante siendo uno de los fármacos más consumidos. No obstante, el tratamiento con estatinas no… (more)

Subjects/Keywords: Rabdomiolisis; Estatinas; CPK; Rhabdomyolysis; Statins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moreno Carbonell, V. (2016). Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina . (Thesis). Universidad de Extremadura. Retrieved from http://hdl.handle.net/10662/4767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moreno Carbonell, Valentín. “Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina .” 2016. Thesis, Universidad de Extremadura. Accessed March 05, 2021. http://hdl.handle.net/10662/4767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moreno Carbonell, Valentín. “Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina .” 2016. Web. 05 Mar 2021.

Vancouver:

Moreno Carbonell V. Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina . [Internet] [Thesis]. Universidad de Extremadura; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10662/4767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moreno Carbonell V. Elaboración de un sistema analítico-clínico de detección de reacciones adversas musculares por medicación hipolipemiante tipo estatina . [Thesis]. Universidad de Extremadura; 2016. Available from: http://hdl.handle.net/10662/4767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Chang, Saemin. Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms.

Degree: 2013, University of Nevada – Reno

URL: http://hdl.handle.net/11714/3162

► Calcium-dependent protein kinases (CPKs) are Ser/Thr protein kinases that are present in plants, ciliates and apicomplexan parasites. CPKs have a novel structure in which the… (more)

▼ Calcium-dependent protein kinases (CPKs) are Ser/Thr protein kinases that are present in plants, ciliates and apicomplexan parasites. CPKs have a novel structure in which the kinase domain is connected to a calcium-sensing calmodulin-like domain (CaM-LD). The kinase and CaM-LD are connected via an auto-inhibitory junction sequence that can block the enzyme's active site. Like calmodulin, the CaM-LD for a typical CPK contains four calcium-binding EF-hands. The kinase is activated when Ca2+ binding to the CaM-LD changes the enzymes conformation. This conformational change is proposed to either directly disengage the auto-inhibitor from a pseudo-substrate competitive binding interaction with the active site (model-1), or disrupt a non-competitive inhibitory structure that alters access to, or conformation of, the active site (model-2). Here we engineered each of the four EF-hands with Ala substitutions designed to disrupt key Ca2+-binding ligand interactions at positions-1 and -12 within each EF hand. The mutant enzymes were expressed and purified from Escherichia. coli, and then used for in vitro kinase assays with Syntide-2 as a substrate. All four EF-hand mutants showed a 2-fold increase in the amount of Ca2+ required for activation, as well as a more than 2-fold decrease in their maximum activity. These results are consistent with a model in which each EF-hand mutation created a partially inhibited enzyme that was unable to fully disengage from their auto-inhibited conformation. Interestingly, peptide substrate KM determinations indicated that the partially autoinhibited conformations were not equivalent for all four EF-hand mutants. For EF 1 and -2 mutants, the peptide substrate KM for Syntide-2 was 3-fold weaker compared to WT. This is consistent with model-1 in which the auto-inhibitor can function as a competitive inhibitor with respect to a peptide substrate. In contrast, EF3 and 4 mutants showed KM's comparable to WT (only about 1.3-fold weaker), suggesting that these enzymes are still partially inhibited through a non-competitive mechansim. This study provides biochemical evidence that auto-inhibition in a CPK results from a combination of competitive and non-competitive mechanisms, with the N- and C-terminal lobes having kinetically distinct functions. Additional substitutions were made in EF2 to separately test the role of all five residues that have side chains that help coordinate calcium (residue positions-1, -3, -5, -9 and -12 in EF-loop). We found that an Ala substitution of each of the five residues significantly disrupted enzyme activation. Four of the five substitutions (all but position-3) resulted in a more than 2-fold decrease in Vmax, regardless of using high calcium concentrations. The enzymes' 50% calcium activation thresholds (K') were observed at [Ca2+] ≈ 1 μM in most cases except D420A mutant (position-3). The K' of D420A mutant was observed at [Ca2+] ≈ 83 μM, and its activity could be restored to near wild type levels at [Ca2+] ≈ 600 μM. This suggests… Advisors/Committee Members: Harper, Jeffrey F. (advisor), Cushman, John C (committee member), Courchesne, William E (committee member).

Subjects/Keywords: Arabidopsis; Calmodulin-like domain; CPK; CPK34; EF-Hand; Kinase activity assay

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chang, S. (2013). Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/3162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Saemin. “Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms.” 2013. Thesis, University of Nevada – Reno. Accessed March 05, 2021. http://hdl.handle.net/11714/3162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Saemin. “Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms.” 2013. Web. 05 Mar 2021.

Vancouver:

Chang S. Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms. [Internet] [Thesis]. University of Nevada – Reno; 2013. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11714/3162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang S. Auto-inhibition in Calcium-dependent Protein Kinase CPK34 Results from a Combination of Competitive and Non-competitive Mechanisms. [Thesis]. University of Nevada – Reno; 2013. Available from: http://hdl.handle.net/11714/3162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Fukuda, Tsuyoshi Valentim. Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos.

Degree: 2009, Universidade Federal do Amazonas

URL: http://tede.ufam.edu.br/handle/tede/3546

►

A manufatura de produtos eletr?nicos de comunica??o m?vel demanda um controle de qualidade apurado que ? atingido atrav?s de medi??es e de sintonias de cada… (more)

▼

A manufatura de produtos eletr?nicos de comunica??o m?vel demanda um controle de qualidade apurado que ? atingido atrav?s de medi??es e de sintonias de cada unidade produzida. O objetivo deste trabalho ? avaliar o uso de controle estat?stico de processo (CEP) para monitorar a qualidade dos produtos e o ?ndice Cpk de capacidade do processo. Em outras palavras, este estudo compara a sensibilidade do gr?fico de controle para detectar varia??es na m?dia e no desvio padr?o do processo. Nesse sentido, foi usada a medi??o de um par?metro cr?tico do dispositivo produzido, a pot?ncia irradiada. Neste estudo, gr?ficos de controle de Shewhart e de soma cumulativa (CUSUM) foram analisados comparativamente para encontrar o melhor CEP para garantir medi??es mais exatas e dispositivos sintonizados com menores desvios. Shewhart, neste caso, usa a m?dia e o desvio padr?o de amostras observadas num per?odo de tempo definido. Os gr?ficos de controle CUSUM, baseado em somas cumulativas, s?o ferramentas estat?sticas usadas com sucesso para avaliar processos de diferentes ind?strias. O gr?fico de Shewhart foi otimizado para monitorar o ?ndice de capacidade Cpk. De acordo com os resultados obtidos nas condi??es do experimento, o gr?fico de controle CUSUM mostrou maior sensibilidade para pequenos desvios no processo. N?o foi obsevada a efic?cia do gr?fico de Shewhart otimizado para monitorar o ?ndice de capacidade Cpk.

Manufacturing electronic mobile communication products requires high quality control, achieved through measurements and tunings of each unit produced. The goal of this publication is the evaluation of statistical process control (SPC) to monitor the quality of products and the process capability index Cpk. In other words, this study compares the sensitivity of control charts to detect variations in process mean and standard deviation. In this sense, Shewhart control charts and cumulative sum (CUSUM) control charts were comparatively analyzed to select the best SPC in order to guarantee more accurate measurements and devices tuned with lower deviations. Shewhart, in this case, uses the mean and the standard deviation of samples measured during a defined period of time. CUSUM control charts, based on cumulative sums, are statistical tools successfully used to evaluate processes in different industries. The Shewhart control chart was optimized to monitor the capability index Cpk. According to results obtained under the conditions of this experience, CUSUM control chart has higher sensibility when the process has small shifts. It was not observed efficacy of optimized Shewhart control chart to monitor Cpk.

Advisors/Committee Members: Silva, Ocileide Cust?dio da, CPF:78592267404, http://lattes.cnpq.br/6820579608406432.

Subjects/Keywords: CEP; Shewhart; CUSUM, Cpk.; SPC; Shewhart; CUSUM; Cpk.; ENGENHARIAS: ENGENHARIA DE PRODU??O

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fukuda, T. V. (2009). Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/3546

Chicago Manual of Style (16^th Edition):

Fukuda, Tsuyoshi Valentim. “Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos.” 2009. Masters Thesis, Universidade Federal do Amazonas. Accessed March 05, 2021. http://tede.ufam.edu.br/handle/tede/3546.

MLA Handbook (7^th Edition):

Fukuda, Tsuyoshi Valentim. “Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos.” 2009. Web. 05 Mar 2021.

Vancouver:

Fukuda TV. Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2009. [cited 2021 Mar 05]. Available from: http://tede.ufam.edu.br/handle/tede/3546.

Council of Science Editors:

Fukuda TV. Controle estat?stico de processo aplicado ? produ??o de dispositivos eletr?nicos. [Masters Thesis]. Universidade Federal do Amazonas; 2009. Available from: http://tede.ufam.edu.br/handle/tede/3546

4. Fukuda, Tsuyoshi Valentim. Controle estatístico de processo aplicado à produção de dispositivos eletrônicos.

Degree: 2009, Universidade Federal do Amazonas

URL: http://tede.ufam.edu.br/handle/tede/3546

►

A manufatura de produtos eletrônicos de comunicação móvel demanda um controle de qualidade apurado que é atingido através de medições e de sintonias de cada… (more)

▼

A manufatura de produtos eletrônicos de comunicação móvel demanda um controle de qualidade apurado que é atingido através de medições e de sintonias de cada unidade produzida. O objetivo deste trabalho é avaliar o uso de controle estatístico de processo (CEP) para monitorar a qualidade dos produtos e o índice Cpk de capacidade do processo. Em outras palavras, este estudo compara a sensibilidade do gráfico de controle para detectar variações na média e no desvio padrão do processo. Nesse sentido, foi usada a medição de um parâmetro crítico do dispositivo produzido, a potência irradiada. Neste estudo, gráficos de controle de Shewhart e de soma cumulativa (CUSUM) foram analisados comparativamente para encontrar o melhor CEP para garantir medições mais exatas e dispositivos sintonizados com menores desvios. Shewhart, neste caso, usa a média e o desvio padrão de amostras observadas num período de tempo definido. Os gráficos de controle CUSUM, baseado em somas cumulativas, são ferramentas estatísticas usadas com sucesso para avaliar processos de diferentes indústrias. O gráfico de Shewhart foi otimizado para monitorar o índice de capacidade Cpk. De acordo com os resultados obtidos nas condições do experimento, o gráfico de controle CUSUM mostrou maior sensibilidade para pequenos desvios no processo. Não foi obsevada a eficácia do gráfico de Shewhart otimizado para monitorar o índice de capacidade Cpk.

Manufacturing electronic mobile communication products requires high quality control, achieved through measurements and tunings of each unit produced. The goal of this publication is the evaluation of statistical process control (SPC) to monitor the quality of products and the process capability index Cpk. In other words, this study compares the sensitivity of control charts to detect variations in process mean and standard deviation. In this sense, Shewhart control charts and cumulative sum (CUSUM) control charts were comparatively analyzed to select the best SPC in order to guarantee more accurate measurements and devices tuned with lower deviations. Shewhart, in this case, uses the mean and the standard deviation of samples measured during a defined period of time. CUSUM control charts, based on cumulative sums, are statistical tools successfully used to evaluate processes in different industries. The Shewhart control chart was optimized to monitor the capability index Cpk. According to results obtained under the conditions of this experience, CUSUM control chart has higher sensibility when the process has small shifts. It was not observed efficacy of optimized Shewhart control chart to monitor Cpk.

Advisors/Committee Members: Silva, Ocileide Custodio da, CPF:78592267404, http://lattes.cnpq.br/6820579608406432.

Subjects/Keywords: CEP; Shewhart; CUSUM, Cpk.; SPC; Shewhart; CUSUM; Cpk.; ENGENHARIAS: ENGENHARIA DE PRODUÇÃO

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fukuda, T. V. (2009). Controle estatístico de processo aplicado à produção de dispositivos eletrônicos. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/3546

Chicago Manual of Style (16^th Edition):

Fukuda, Tsuyoshi Valentim. “Controle estatístico de processo aplicado à produção de dispositivos eletrônicos.” 2009. Masters Thesis, Universidade Federal do Amazonas. Accessed March 05, 2021. http://tede.ufam.edu.br/handle/tede/3546.

MLA Handbook (7^th Edition):

Fukuda, Tsuyoshi Valentim. “Controle estatístico de processo aplicado à produção de dispositivos eletrônicos.” 2009. Web. 05 Mar 2021.

Vancouver:

Fukuda TV. Controle estatístico de processo aplicado à produção de dispositivos eletrônicos. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2009. [cited 2021 Mar 05]. Available from: http://tede.ufam.edu.br/handle/tede/3546.

Council of Science Editors:

Fukuda TV. Controle estatístico de processo aplicado à produção de dispositivos eletrônicos. [Masters Thesis]. Universidade Federal do Amazonas; 2009. Available from: http://tede.ufam.edu.br/handle/tede/3546

Brno University of Technology

5. Kluz, David. Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES).

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/27216

► This thesis analyzes the company Hyundai Dymos English due to the awareness of management of the production status. During the work are identified important production… (more)

Subjects/Keywords: GMES; Pest analýza; Porter analýza; Analýza 7s; SWOT analýza; Kvalitativní ukazatele; CP; CPK; C#; Android.; GMES; Pest analysis; Porter analysis; Analysis 7s; SWOT analysis; Qualitative indicators; CP; CPK; C#; Android.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kluz, D. (2019). Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES). (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/27216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kluz, David. “Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES).” 2019. Thesis, Brno University of Technology. Accessed March 05, 2021. http://hdl.handle.net/11012/27216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kluz, David. “Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES).” 2019. Web. 05 Mar 2021.

Vancouver:

Kluz D. Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES). [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11012/27216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kluz D. Systém pro snadné sledování a vyhodnocování výrobních procesů (GMES): System for Easy Monitoring and Evaluating Production Processes (GMES). [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/27216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. 飴野, 節子. 血清CPKに関する外傷法医学的研究.

Degree: 博士（医学）, 1982, Okayama University / 岡山大学

URL: http://ousar.lib.okayama-u.ac.jp/1827

Subjects/Keywords: 血清CPK; 外傷法医学

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

飴野, �. (1982). 血清CPKに関する外傷法医学的研究. (Thesis). Okayama University / 岡山大学. Retrieved from http://ousar.lib.okayama-u.ac.jp/1827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

飴野, 節子. “血清CPKに関する外傷法医学的研究.” 1982. Thesis, Okayama University / 岡山大学. Accessed March 05, 2021. http://ousar.lib.okayama-u.ac.jp/1827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

飴野, 節子. “血清CPKに関する外傷法医学的研究.” 1982. Web. 05 Mar 2021.

Vancouver:

飴野 �. 血清CPKに関する外傷法医学的研究. [Internet] [Thesis]. Okayama University / 岡山大学; 1982. [cited 2021 Mar 05]. Available from: http://ousar.lib.okayama-u.ac.jp/1827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

飴野 �. 血清CPKに関する外傷法医学的研究. [Thesis]. Okayama University / 岡山大学; 1982. Available from: http://ousar.lib.okayama-u.ac.jp/1827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

7. Bering, Thomas P.K. Software Profiling of Rogue Events in High-Volume Gauging.

Degree: PhD, 2013, McMaster University

URL: http://hdl.handle.net/11375/13116

►

Customers are placing ever increasing demands on automotive part manufacturers for high quality parts at low cost. Increasingly, the demand is for zero defects… (more)

▼

Customers are placing ever increasing demands on automotive part manufacturers for high quality parts at low cost. Increasingly, the demand is for zero defects or defect rates in the less than one part per billion. This creates a significant challenge for manufacturers as to how to achieve these low defect levels economically while producing large volumes of parts. Importantly, the presence of infrequent process and measurement (gauge) events can adversely affect product quality. This thesis uses a statistical mixture model that allows one to assume a main production process that occurs most of the time, and secondary rogue events that occur infrequently. Often the rogue events correspond to necessary operator activity, like equipment repairs and tooling replacement. The mixture model predicts that some gauge observations will be influenced by combinations of these rogue events. Certain production applications, like those involving feedback or high-reliability gauging, are heavily influenced by rogue events and combinations of rogue events. A special runtime software profiler was created to collect information about rogue events, and statistical techniques (rogue event analysis) were used to estimate the waste generated by these rogue events. The value of these techniques was successfully demonstrated in three different industrial automotive part production applications. Two of these systems involve an automated feedback application with Computer Numerically Controlled (CNC) machining centers and Coordinate Measuring Machine (CMM) gauges. The third application involves a high-reliability inspection system that used optical, camera-based, machine-vision technology. The original system accepted reject parts at a rate of 98.7 part per million (ppm), despite multiple levels of redundancy. The final system showed no outgoing defects on a 1 million part factory data sample, and a 100 million part simulated data sample. It is expected that the final system reliability will meet the 0.001 ppm specification, which represents a huge improvement.

Doctor of Philosophy (PhD)

Advisors/Committee Members: Veldhuis, Stephen C., Macdonald, Peter D.M., Bone, Gary, Mechanical Engineering.

Subjects/Keywords: Profiling; Mixture Models; Gauge; Reliability; Automotive; Production; GR&R; Cpk; Applied Statistics; Manufacturing; Mechanical Engineering; Applied Statistics

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bering, T. P. K. (2013). Software Profiling of Rogue Events in High-Volume Gauging. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/13116

Chicago Manual of Style (16^th Edition):

Bering, Thomas P K. “Software Profiling of Rogue Events in High-Volume Gauging.” 2013. Doctoral Dissertation, McMaster University. Accessed March 05, 2021. http://hdl.handle.net/11375/13116.

MLA Handbook (7^th Edition):

Bering, Thomas P K. “Software Profiling of Rogue Events in High-Volume Gauging.” 2013. Web. 05 Mar 2021.

Vancouver:

Bering TPK. Software Profiling of Rogue Events in High-Volume Gauging. [Internet] [Doctoral dissertation]. McMaster University; 2013. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11375/13116.

Council of Science Editors:

Bering TPK. Software Profiling of Rogue Events in High-Volume Gauging. [Doctoral Dissertation]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/13116

8. Bourdenet, Gwladys. Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway.

Degree: Docteur es, Aspects moleculaires et cellulaires de la biologie, 2017, Normandie

URL: http://www.theses.fr/2017NORMR062

►

Les myopathies inflammatoires (MI) représentent un groupe hétérogène de maladies caractérisépar une faiblesse musculaire chronique et symétrique associée à une augmentation du taux sérique decréatine… (more)

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Les myopathies inflammatoires (MI) représentent un groupe hétérogène de maladies caractérisépar une faiblesse musculaire chronique et symétrique associée à une augmentation du taux sérique decréatine phosphokinase (CPK). Les MI sont actuellement subdivisées en 5 entitées : les dermatomyosites,les myopathies nécrosantes auto-immunes, la myosite à inclusion, la polymyosite et les myosites dechevauchement. A ce jour, le diagnostic des MI repose sur l’association de signes cliniques, decaractéristiques anatomopathologiques sur la biopsie musculaire et la présence d’auto-anticorps (aAc). Eneffet, la découverte d’aAc spécifiques et/ou associés aux myosites (MSA/MAA) a considérablementamélioré le diagnostic et le pronostic de la maladie. Cependant, un nombre non négligeable de patientsatteints de MI sont séronégatifs pour les MSA/MAA connus. Par ailleurs, la biopsie musculaire nécessaireau diagnostic est parfois guidée par imagerie par résonance magnétique (IRM), bien qu’il n’ait pas étéprouvé que les données d’imagerie soient corrélées aux signes histologiques. Enfin, le traitement des MIrepose sur l’utilisation d’immunosuppresseurs systémiques, une approche non spécifique de laphysiopathologie de la maladie. Les modèles animaux de MI les plus utilisés sont induits et nonspontanés : ils reposent principalement sur l’immunisation d’animaux contre des protéines telles que lamyosine, la protéine C ou l’histidyl-tRNA synthétase.Les souris NOD (non obese diabetic) sont le modèle classique d’étude du diabète de type 1.Lorsque ces souris sont invalidées pour la voie de costimulation lymphocytaire ICOS/ICOSL, les souris nedéveloppent plus de diabète mais présentent alors une atteinte musculaire. Dans ce travail, nous avonsétudié le phénotype et caractérisé l’atteinte musculaire des souris NOD Icos-/- et NOD Icosl-/-. Nous avonsainsi établi le 1er modèle murin spontané de MI, dont la physiopathologie est médiée par leslymphocytes T CD4+ et la sécrétion d’IFN-γ. Par ailleurs, ces souris présentent un déficit en lymphocytes Trégulateurs. Nous avons également identifié 4 auto-antigènes (aAg) candidats cibles d’aAc chez ces souris.La recherche des aAc correspondants aux aAg orthologues dans le sérum des patients atteints de MI apermis d’identifier, pour l’un d’entre eux, une minorité d’individus séropositifs grâce au développementd’un nouveau test ALBIA (addressable laser bead immunoassay). Il pourrait donc s’agir d’un nouveaubiomarqueur. Dans la perspective de nouvelles évaluations thérapeutiques, nous avons établi desdonnées préliminaires montrant que l’interleukine 2 à faibles doses permet de retarder l’apparition de lamaladie. Enfin, nous avons mis à profit ce modèle et démontré la corrélation entre les données généréespar IRM et par analyse histologique de l’inflammation, confortant le rôle de cette technique d’imagerie àla fois pour le diagnostic et le suivi des MI.

Inflammatory Myopathies (IM) are a heterogeneous group of diseases characterized bychronic and symmetrical muscle weakness associated to increased creatine…

Advisors/Committee Members: Boyer, Olivier (thesis director), Martinet, Jérémie (thesis director).

Subjects/Keywords: Myopathies inflammatoires; Physiopathologie; Auto-anticorps; Biomarqueurs; Costimulation; ICOS/ICOSL; IRM musculaire; Inflammatory Myopathies (IM); Muscle weakness; Creatine phosphokinase (CPK); 616.74

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bourdenet, G. (2017). Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway. (Doctoral Dissertation). Normandie. Retrieved from http://www.theses.fr/2017NORMR062

Chicago Manual of Style (16^th Edition):

Bourdenet, Gwladys. “Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway.” 2017. Doctoral Dissertation, Normandie. Accessed March 05, 2021. http://www.theses.fr/2017NORMR062.

MLA Handbook (7^th Edition):

Bourdenet, Gwladys. “Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway.” 2017. Web. 05 Mar 2021.

Vancouver:

Bourdenet G. Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway. [Internet] [Doctoral dissertation]. Normandie; 2017. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2017NORMR062.

Council of Science Editors:

Bourdenet G. Étude physiopathologique de la myopathie auto-immune des souris NOD invalidées pour la voie de costimulation ICOS/ICOSL. : Physiopathological study of autoimmune myopathy in disabled NOD mice for the ICOS/ICOSL costimulation pathway. [Doctoral Dissertation]. Normandie; 2017. Available from: http://www.theses.fr/2017NORMR062

Ohio University

9. Datar, Satyajit V. Hypothesis Testing for the Process Capability Ratio.

Degree: MS, Industrial and Manufacturing Systems Engineering (Engineering), 2002, Ohio University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040054409

► Process Capability Indices are used in the industry as decision making tools. The values of the indices are estimated from a sample and should… (more)

Subjects/Keywords: Statistics; Hypothesis Test; Process Capability Ratio; Cp and Cpk

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APA (6^th Edition):

Datar, S. V. (2002). Hypothesis Testing for the Process Capability Ratio. (Masters Thesis). Ohio University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040054409

Chicago Manual of Style (16^th Edition):

Datar, Satyajit V. “Hypothesis Testing for the Process Capability Ratio.” 2002. Masters Thesis, Ohio University. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040054409.

MLA Handbook (7^th Edition):

Datar, Satyajit V. “Hypothesis Testing for the Process Capability Ratio.” 2002. Web. 05 Mar 2021.

Vancouver:

Datar SV. Hypothesis Testing for the Process Capability Ratio. [Internet] [Masters thesis]. Ohio University; 2002. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040054409.

Council of Science Editors:

Datar SV. Hypothesis Testing for the Process Capability Ratio. [Masters Thesis]. Ohio University; 2002. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040054409

Mid Sweden University

10. Östmalm, Josefin. Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?.

Degree: Information Systems and Technology, 2018, Mid Sweden University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35799

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The aim of this study was to research which Lean principles that could be incorporated in a small company. Lean is a more and… (more)

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The aim of this study was to research which Lean principles that could be incorporated in a small company. Lean is a more and more common expression that has become popular among companies that strive to find new ways of improvement and creating ways to compete on the market. Lean as whole can be viewed as methods to increase the effectiveness of ones working processes through handling waste and increasing customer value. The company that was chosen for this study was Lundqvist Trävaru AB, a small family company located in the city of Piteå in northern parts of Sweden. Their main product is to create wall blocks that can be assembled into garages, cottages and storage units. The study was constructed in physical visits to the company while conducting participatory interviews and observations. A theory study was also conducted to find information important to carry on studying and analyzing the subject. The collected data was compiled into value stream maps and spaghetti diagrams covering the work in the factory of the company, then a MUDA-analysis was made to locate different types of waste and suggestions of improvements to eliminate this waste. To quantify the study a capacity process index (Cp) and specific capacity index (Cpk) was calculated and compared to the numbers in theory. The results showed that there are good possibilities to implements Lean principles into the company. The Cp and Cpk -index that was calculated gave an unclear result, this probably as a result of it being a difficult process to demonstrate this type of calculation. The conclusion of the study is that it has given a result and that there are possibilities to conduct further studies on the subject.

Studien har syftat på att undersöka vilka Leanprinciper som skulle kunna inkorporeras i ett mindre företag. Lean är ett uttryck som blir allt mer vanligt bland företag som strävar efter att finna nya sätt att förbättra sig och bli mer konkurrenskraftiga på marknaden. Lean som helhet kan ses som metoder till att effektivisera arbetsprocesserna i en verksamhet genom att minska spill och öka kundvärdet. Företaget som undersöks i studien är Lundkvist Trävaru AB, ett mindre företag lokaliserat i Piteå, i norra Sverige. Deras huvudprodukt är att bygga väggblock som sedan kan monteras ihop till bland annat garage, fritidshus och förråd. Studien genomfördes med besök på företaget för deltagande observationer och intervjuer samt genomfördes en teoristudie för att hitta den information som ansågs väsentlig för att studera och analysera ämnet. Data sammanställdes därefter i form av värdeflödeskartor och spagettidiagram över processen i företagets fabrik. En MUDA-analys genomfördes över den större delen av verksamheten för att lokalisera vart det kan uppkomma spill och vilka förbättringar som skulle kunna genomföras för att motverka detta spill. Ett kapacitetprocessindex (Cp) och ett specifikt kapacitetsprocessindex (Cpk) togs fram för att jämföras mot de siffror som finns i teorin. Resultatet visade att det finns goda möjligheter…

Subjects/Keywords: Lean production; MUDA; Cp-index; Cpk-index; Value Stream Mapping; participatory observations.; Lean production; MUDA; Cp-index; Cpk-index; värdeflödeskartor; deltagande observationer.; Other Engineering and Technologies not elsewhere specified; Övrig annan teknik

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Östmalm, J. (2018). Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?. (Thesis). Mid Sweden University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Östmalm, Josefin. “Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?.” 2018. Thesis, Mid Sweden University. Accessed March 05, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Östmalm, Josefin. “Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?.” 2018. Web. 05 Mar 2021.

Vancouver:

Östmalm J. Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?. [Internet] [Thesis]. Mid Sweden University; 2018. [cited 2021 Mar 05]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Östmalm J. Effektivisering med hjälp av Lean : Hur kan principerna om Lean appliceras för att förbättra arbetsprocesserna i en organisation?. [Thesis]. Mid Sweden University; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Western Kentucky University

11. Austin, Andrew. Process Capability in a Computer Integrated Manufacturing Cell.

Degree: MS, Department of Architectural and Manufacturing Sciences, 2014, Western Kentucky University

URL: https://digitalcommons.wku.edu/theses/1322

► With the rise of automation in traditional manufacturing processes, more companies are beginning to integrate computer integrated manufacturing (CIM) cells on their production floors.… (more)

▼ With the rise of automation in traditional manufacturing processes, more companies are beginning to integrate computer integrated manufacturing (CIM) cells on their production floors. Through CIM cell integration, companies have the ability to reduce process time and increase production. One of the problems created with CIM cell automation is caused by the dependency the sequential steps have on one another. Dependency created by the previous step increases the probability that a process error could occur due to previous variation. One way to eliminate this dependency is through the use of an in-process measuring device such as a Renishaw spindle probe used in conjunction with a computer numerical control (CNC) milling machine. Western Kentucky University (WKU) utilizes a CIM cell in the Senator Mitch McConnell Advanced Manufacturing and Robotics laboratory. The laboratory is located in the Architectural and Manufacturing Sciences department and gives students the opportunity to learn how automated systems can be integrated. The CIM cell consists of three Mitsubishi six-axis robots, a Haas Mini-mill, a Haas GT-10 lathe, an AXYZ, Inc. CNC router table, 120 watt laser engraver, an Automated Storage and Retrieval System (ASRS), material handling conveyor, and vision station. The CIM cell functions throughout the curriculum as a means for applied learning and research. The researcher used this CIM cell in order to determine if an in-process measuring device, such as the Renishaw spindle probe, had the ability to affect process capability. The researcher conducted the study to see if an in-process measuring device can be integrated into the CIM cell located in the Senator Mitch McConnell Advanced Manufacturing and Robotics laboratory to eliminate compounding variation. The researcher discovered that through the use of a Renishaw 40-2 spindle probe used in conjunction with a CNC Haas Mini Mill, process capability has the potential to be improved in a CIM cell by accounting for compounding variation present in the process. Advisors/Committee Members: Greg Arbuckle (Director), Mark Doggett, Bryan Reaka.

Subjects/Keywords: Manufacturing; Computer Numerical Control (CNC); Variation; Cp; Cpk; Computer Integrated Manufacturing Systems; Engineering Design- Data Processing; Computer-Aided Engineering and Design; Electro-Mechanical Systems; Engineering; Manufacturing; Mechanical Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Austin, A. (2014). Process Capability in a Computer Integrated Manufacturing Cell. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/1322

Chicago Manual of Style (16^th Edition):

Austin, Andrew. “Process Capability in a Computer Integrated Manufacturing Cell.” 2014. Masters Thesis, Western Kentucky University. Accessed March 05, 2021. https://digitalcommons.wku.edu/theses/1322.

MLA Handbook (7^th Edition):

Austin, Andrew. “Process Capability in a Computer Integrated Manufacturing Cell.” 2014. Web. 05 Mar 2021.

Vancouver:

Austin A. Process Capability in a Computer Integrated Manufacturing Cell. [Internet] [Masters thesis]. Western Kentucky University; 2014. [cited 2021 Mar 05]. Available from: https://digitalcommons.wku.edu/theses/1322.

Council of Science Editors:

Austin A. Process Capability in a Computer Integrated Manufacturing Cell. [Masters Thesis]. Western Kentucky University; 2014. Available from: https://digitalcommons.wku.edu/theses/1322

12. Ronzier, Elsa. Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?.

Degree: Docteur es, Biologie Intégrative des Plantes, 2013, Montpellier, SupAgro

URL: http://www.theses.fr/2013NSAM0021

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Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress… (more)

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Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? Les canaux potassiques de la famille Shaker sont des voies majeures du transport de K+ à travers la membrane plasmique. Ces canaux sont impliqués dans l'absorption du potassium depuis le sol et dans sa redistribution dans les parties aériennes de la plante. Ils sont également impliqués dans les mouvements stomatiques et sont pour cela finement régulés. Ils peuvent subir des modifications post-traductionnelles telle que la phosphorylation par des protéines kinases. L'objectif principal de ce travail de thèse s'inscrit dans ce contexte et a pour but d'évaluer l'implication des CPKs dans la régulation post-traductionnelle des canaux Shaker. Les mécanismes d'action de deux CPKs (CPK13 et CPK6) sur la sous-unité entrante KAT2 sont plus spécifiquement étudiés. La première partie du travail de thèse avait pour but de mettre en place le matériel nécessaire pour l'étude en réalisant les clonages, la production des protéines recombinantes et leur caractérisation et testant les premiers effets des CPKs sur l'activité des canaux en expression hétérologue. La seconde partie concerne l'étude du rôle de CPK13 dans la régulation stomatique via la sous-unité KAT2. Nous montrons que la sur-expression de CPK13 dans les lignées transgéniques induit, à court terme, un défaut dans l'ouverture stomatique et également, à long terme, un défaut dans la croissance de la plante. L'existence d'une interaction physique à la membrane plasmique entre CPK13 et KAT2 est montrée à l'aide de la technique de FRET-FLIM. et la phosphorylation de la sous-unité KAT2 par la protéine recombinante CPK13 est montrée in vitro à l'aide de puces à peptides. Enfin, il est montré par voltage-clamp en ovocyte de xénope que CPK13 inhibe l'activité de KAT2 de plus de 60%. Dans la dernière partie, nous présentons un ensemble de résultats qui suggèrent un rôle de CPK6 dans la tolérance au stress salin via son action sur KAT2. Il est en effet connu qu'en cas de stress salin, l'activité des canaux responsables de l'influx de potassium est stimulée, ce qui contribue au maintien d'un faible ratio Na+/K+ dans les cellules. Or, nous montrons un effet activateur de la CPK6 sur l'activité de KAT2, à l'aide de la technique de voltage-clamp. Nous montrons que l'expression du gène CPK6 est très augmentée en réponse à un stress salin et que ceci est concomitant avec le déclenchement d'une vague calcique en réponse à ce même stress. L'utilisation de lignées GUS a permis de vérifier que les patrons d'expression des gènes CPK6 et KAT2 sont identiques chez Arabidopsis thaliana. Enfin, nous montrons une interaction physique entre le canal KAT2 et la protéine CPK6 (FRET-FLIM) et la phosphorylation de KAT2 par CPK6 (puces à peptides).

Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana: a role in adaptive response to…

Advisors/Committee Members: Thibaud, Jean-Baptiste (thesis director), Xiong, Tou Cheu (thesis director).

Subjects/Keywords: Arabidopsis thaliana; Signalisation calcique; CPKs; Canaux Shaker; Modification post-Traducionelle; Adaptation au stress; Arabidopsis thaliana; Calcium signaling; Cpk; Shaker channels; Post-Translational regulation; Stress adaptation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ronzier, E. (2013). Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?. (Doctoral Dissertation). Montpellier, SupAgro. Retrieved from http://www.theses.fr/2013NSAM0021

Chicago Manual of Style (16^th Edition):

Ronzier, Elsa. “Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?.” 2013. Doctoral Dissertation, Montpellier, SupAgro. Accessed March 05, 2021. http://www.theses.fr/2013NSAM0021.

MLA Handbook (7^th Edition):

Ronzier, Elsa. “Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?.” 2013. Web. 05 Mar 2021.

Vancouver:

Ronzier E. Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?. [Internet] [Doctoral dissertation]. Montpellier, SupAgro; 2013. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2013NSAM0021.

Council of Science Editors:

Ronzier E. Régulation post-traductionnelle des canaux potassiques par les CPKs (Protéines Kinases Dépendantes du Calcium) chez Arabidopsis thaliana : un rôle dans la réponse adaptative aux stress environnementaux ? : Post-translational regulation of potassium channels by CPKs (Calcium-dependent Protein Kinases) in Arabidopsis thaliana : a role in adaptive response to environmental stresses ?. [Doctoral Dissertation]. Montpellier, SupAgro; 2013. Available from: http://www.theses.fr/2013NSAM0021

Freie Universität Berlin

13. Liese, Anja. Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction.

Degree: 2013, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11067

► Calcium-dependent protein kinases (CDPKs) are implicated in the perception of stress- and developmental stimuli-induced changes in Ca2+ concentrations and their respective translation into specific phosphorylation… (more)

▼ Calcium-dependent protein kinases (CDPKs) are implicated in the perception of stress- and developmental stimuli-induced changes in Ca2+ concentrations and their respective translation into specific phosphorylation patterns for signal transduction. This PhD thesis investigates the role of the homologous Arabidopsis thaliana CDPKs CPK21 and CPK23 in abiotic stress and abscisic acid (ABA) signal transduction. For the first time CDPKs were analysed in parallel for rapid ABA signal transduction using transient expression in protoplasts and for long term adaption to abiotic stress using stable transgenic lines. Seedlings of the T-DNA insertion line cpk21-1 (SALK_029412) were shown to be more tolerant to growth under hyper-osmotic conditions. This indicates the influence of CPK21 on the regulation of long term adaption to osmotic stress. Even in the absence of any exposure to stress, an increased abiotic stress response with respect to abiotic stress and also ABA-induced marker gene expression was demonstrated for both T-DNA insertion lines cpk21-1 and cpk23-1 (SALK_007958). The role of the in vivo function of CPK21 and CPK23 in rapid ABA signal transduction was addressed in A. thaliana leaf mesophyl protoplasts using pRD29B::LUC as molecular read-out. These assays allowed the identification of CPK21 and CPK23 as negative regulators of the rapid abiotic stress and ABA signal transduction. In in vivo interaction and phosphorylation studies with components of the ABA signal transduction pathways for e.g. anion channels, in vivo targets and interactors could be identified. A second key aspect is the Ca2+-dependent regulation of CPK21 and CPK23 protein kinase activity. No Ca2+-dependency of CPK23 kinase activity could be observed in contrast to a high Ca2+-dependency for CPK21 kinase activity. Thus CPK23 could be identified as the first Ca2+ independent CDPK, leading to the question of amino acid variations in highly homologous proteins. Two crucial amino acids could be identified in CPK23: I. -Q393- The Ca2+-binding loop of the EF-hand1 of CPK23 did not match the Ca2+-binding consensus motif. Therefore a more specific Ca2+-binding site via reversion of Q393 to E was generated. II. -S362- Via comparison of the pseudosubstrate segment of CPKs serine (S362) in CPK23 could be identified in place of the CPK consensus isoleucin. Mutation of this serine to isoleucine and the amino acid exchange in EF-hand 1 form Q393 to E resulted to a regain of Ca2+-dependency of kinase activity. For the first time CDPKs could be characterised starting from enzyme activity, based on single crucial amino acids, leading to their function in the rapid ABA signal transduction and in the long term adaption to abiotic stress. Advisors/Committee Members: w (gender), Prof. Wolfgang Schuster (inspector), Dr. Claus-Peter Witte (inspector), Dr. Britta Ehlert (inspector), Prof.Tina Romeis (firstReferee), Prof. Rupert Mutzel (furtherReferee).

Subjects/Keywords: CPK; EF-hand; signal transduction; ABA; abiotic stress; calcium-dependent regulation; kinase activity; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liese, A. (2013). Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liese, Anja. “Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction.” 2013. Thesis, Freie Universität Berlin. Accessed March 05, 2021. https://refubium.fu-berlin.de/handle/fub188/11067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liese, Anja. “Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction.” 2013. Web. 05 Mar 2021.

Vancouver:

Liese A. Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Mar 05]. Available from: https://refubium.fu-berlin.de/handle/fub188/11067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liese A. Regulation and function of AtCPK21 and AtCPK23 in abiotic stress response and ABA signal transduction. [Thesis]. Freie Universität Berlin; 2013. Available from: https://refubium.fu-berlin.de/handle/fub188/11067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Bundó Barberà, Mireia. Calcium-dependent protein kinases in the stress signaling cascades of rice plants.

Degree: Departament de Bioquímica i Biologia Molecular, 2015, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/319699

► Calcium-dependent protein kinases (CDPKs or CPKs) are signaling components in many aspects of plant biology, from developmental processes to stress responses. This thesis addresses the… (more)

▼ Calcium-dependent protein kinases (CDPKs or CPKs) are signaling components in many aspects of plant biology, from developmental processes to stress responses. This thesis addresses the identification and functional characterization of the OsCPK isoforms mediating the rice defense response to pathogens, as well as their contribution to other signaling pathways. These studies are important to understand the interactions between different stress signaling pathways and the development process in rice plants. A better understanding of these crosstalks among signaling pathways, as well as the identification of the signaling components mediating them, are relevant to develop strategies to improve plant stress tolerance. All these studies apply to rice plants, an economical and social important crop worldwide. The work of this thesis is divided in three chapters. The first chapter focuses on the identification of OsCPK genes involved in the defense response to the rice blast fungal pathogen Magnaporthe oryzae by global expression analysis. These studies complemented with specific expression profile analyses which identified OsCPK4 and OsCPK10 as upregulated genes in response to M. oryzae fungal infection, although the OsCPK5 and OsCPK13 genes were also responding to fungal elicitors. The second chapter addresses the functional characterization of the OsCPK4 gene in the rice defense response to the M. oryzae pathogen. The overexpression of the OsCPK4 gene conferred enhanced resistance to M. oryzae infection in rice plants by potentiating their defense responses, including the production of reactive oxygen species, callose deposition, and defense gene expression, associated to an increased accumulation of conjugated salicylic acid in leaves without compromising rice yield. Given that OsCPK4 overexpression was known to confer also salt and drought tolerance in rice, these results demonstrate that OsCPK4 acts as a convergence component that positively modulates both biotic and abiotic signaling pathways in rice. The functional characterization of the OsCPK10 gene is presented in the third chapter. These studies demonstrate that OsCPK10 is also a positive modulator of both the defense response to M. oryzae infection and the drought stress response in rice plants. The constitutive accumulation of OsCPK10 conferred the rice plants with an improved tolerance to oxidative stress by increasing their antioxidant capacity. This improved capacity to scavenge the produced toxic hydrogen peroxide upon desiccation is due in part to an increased accumulation of the Catalase A, which leads to a reduction in lipid peroxidation and preservation of the cellular membrane integrity, and as a result drought stress tolerance. All together, the results of this thesis identify the OsCPK4 and the OsCPK10 proteins as convergence components that positively modulate both biotic and abiotic signaling pathways, suggesting they are good molecular targets to improve tolerance to different stresses in rice plants. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Coca, María (director), Llugany, Mercè (tutor), true (authorsendemail).

Subjects/Keywords: CPK; Arròs; Arroz; Rice; Estrès; Estrés; Stress; Ciències Experimentals; 577

…Figure I.6: CPK structure and activation 22 Figure I.7: Schematic representations of the… …or CPK cv. dpi DRE DREB erd ET ETI ETS EV GA GFP GPX hpi HR JA LEA MAPK MAPKK MDA MV PAMP…

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APA (6^th Edition):

Bundó Barberà, M. (2015). Calcium-dependent protein kinases in the stress signaling cascades of rice plants. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/319699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bundó Barberà, Mireia. “Calcium-dependent protein kinases in the stress signaling cascades of rice plants.” 2015. Thesis, Universitat Autònoma de Barcelona. Accessed March 05, 2021. http://hdl.handle.net/10803/319699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bundó Barberà, Mireia. “Calcium-dependent protein kinases in the stress signaling cascades of rice plants.” 2015. Web. 05 Mar 2021.

Vancouver:

Bundó Barberà M. Calcium-dependent protein kinases in the stress signaling cascades of rice plants. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2015. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10803/319699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bundó Barberà M. Calcium-dependent protein kinases in the stress signaling cascades of rice plants. [Thesis]. Universitat Autònoma de Barcelona; 2015. Available from: http://hdl.handle.net/10803/319699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Franz, Sandra. Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana.

Degree: 2008, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12013

► Calcium-dependent protein kinases (CDPKs) are Ser/Thr protein kinases which perceive changes in cytoplasmic calcium concentrations and translate them into defined phosphorylation patterns for signaltransduction in… (more)

▼ Calcium-dependent protein kinases (CDPKs) are Ser/Thr protein kinases which perceive changes in cytoplasmic calcium concentrations and translate them into defined phosphorylation patterns for signaltransduction in a continuously changing environment. This PhD thesis addresses the role of the two closest homologs CPK21 and CPK23 from Arabidopsis thaliana in signaltransduction events upon salt - and hyperosmotic stress. Phenotypical characterisation of two T-DNA insertion lines cpk21 (SALK_029412) and cpk23 (SALK_007958) identified CPK21 and CPK23 as putative negative regulators in the salt stress response, with an unknown function in particular in response to the osmotic component of salt stress. Measurements of the sodium- and potassium content in green tissues of Col-0, cpk21 and cpk23 showed a higher K+/Na+-ratio in cpk23 compared to Col-0 after one day exposure to 100 mM NaCl. RT-PCR based expression studies showed an induction of CPK21 expression after salt – and hyperosmotic stress and ABA application. CPK23 transcript accumulation was observed in response to hyperosmotic stress and ABA application. The biochemical in vivo activation of CPK21 after ABA application, salt – and hyperosmotic stress additionally refers to a role of the enzyme in salt signaltransduction. For further biochemical characterisation of AtCPK21 the role of calcium binding for enzyme activity was investigated. Therefore different StrepII-tagged enzyme variants, with single mutations in all four EF-hands (EF1, EF2, EF3 oder EF4) and double mutations in either the C-terminal or N-terminal EF-hand pair, preventing calcium binding, were transiently expressed in N. benthamiana. After purification a kinase assay with different calcium concentrations was performed. It was shown that the N-terminal EF-hands were essential for biochemical activation of CPK21. Physiological studies using Col-0, the two T-DNA insertion lines cpk21 and cpk23 and cpk21 and cpk23, expressing the generated CPK21- and CPK23- enzyme variants under control of the 35S-promoter showed different abilities of the enzyme variants to complement the mutant phenotype dependent on their in vitro enzyme activity. This study showed for the first time a correlation between Ca2+ - dependent in vitro kinase activity and in vivo function for CDPKs. Advisors/Committee Members: n (gender), Prof. Kürsad Turgay (inspector), Prof. Wolfgang Schuster (inspector), Prof. Tina Romeis (firstReferee), Prof. Rupert Mutzel (furtherReferee), Dr. Claus-Peter Witte (furtherReferee).

Subjects/Keywords: CPK; Arabidopsis thaliana; Salzstress; EF-Hand; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

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APA (6^th Edition):

Franz, S. (2008). Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12013

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Franz, Sandra. “Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana.” 2008. Thesis, Freie Universität Berlin. Accessed March 05, 2021. http://dx.doi.org/10.17169/refubium-12013.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Franz, Sandra. “Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana.” 2008. Web. 05 Mar 2021.

Vancouver:

Franz S. Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana. [Internet] [Thesis]. Freie Universität Berlin; 2008. [cited 2021 Mar 05]. Available from: http://dx.doi.org/10.17169/refubium-12013.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Franz S. Characterisation of the CDPKs CPK21 & CPK23 from Arabidopsis thaliana. [Thesis]. Freie Universität Berlin; 2008. Available from: http://dx.doi.org/10.17169/refubium-12013

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Hansson, Jonatan. Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner.

Degree: Mechanical Engineering, 2019, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84864

► Inom industriell tillverkning har alla maskiner en teoretisk duglighet. Den skiljer sig däremot från den faktiska när den sätts i en process, där påverkas… (more)

Subjects/Keywords: Duglighet; Duglighetsstudie; Cpk; Kvalitetsutveckling; Plåtberedning; Statistisk processtyrning; Reliability and Maintenance; Tillförlitlighets- och kvalitetsteknik

…dock vanligast att beräkna duglighet m.h.a. duglighetsindexen Cp och Cpk. För att resultatet… …tar hänsyn till huruvida processens utfall ligger centrerat kring målvärdet eller inte. Cpk… …processens utfall är (Spiring 2010). Cpk utgörs av en kombination av två duglighetsindex… …figur 3. Cpk har liknande värden. Där ett Cpk-värde på 1,33 ger 63 detaljer utanför toleransen… …brukar använda värdet på Cpk ovan för att bedöma huruvida deras process är kapabel. 3.6…

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APA (6^th Edition):

Hansson, J. (2019). Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84864

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hansson, Jonatan. “Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner.” 2019. Thesis, Linnaeus University. Accessed March 05, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84864.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hansson, Jonatan. “Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner.” 2019. Web. 05 Mar 2021.

Vancouver:

Hansson J. Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner. [Internet] [Thesis]. Linnaeus University; 2019. [cited 2021 Mar 05]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84864.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hansson J. Studie av process och maskinduglighet på Electrolux Laundry Systems plåtberedningsmaskiner. [Thesis]. Linnaeus University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84864

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. ΣΙΑΦΑΚΑ, ΙΩΑΝΝΑ. ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ.

Degree: 1985, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/0388

►

IT WAS DISCOVERED FROM THE CONCLUSIONS THAT THERE IS A STATISTICALLY SIGNIFICANT DIFFERENCE IN THE MEAN RATE OF SERUM CPK BEFORE THE ANAESTHESIA ALLOWANCE, FROM… (more)

▼

IT WAS DISCOVERED FROM THE CONCLUSIONS THAT THERE IS A STATISTICALLY SIGNIFICANT DIFFERENCE IN THE MEAN RATE OF SERUM CPK BEFORE THE ANAESTHESIA ALLOWANCE, FROM THE MEAN RATE OF CPK AFTER THE ANAESTHESIA ALLOWANCE, IN BOTH KINDS OF CHILD BIRTH. IT WAS ALSO PROVED THAT THE MEAN QUANTITY OF TOTAL SERUM CPK IN THENATURAL CHILD BIRTH, IS BIGGER THAN THAT IN THE CAESARIAN SECTION REGARDLESS OF HAVING TAKEN THE BLOOD SAMPLE BEFORE OR AFTER THE ANAESTHESIA ALLOWANCE. ATLAST IT SEEMED FROM THE STUDY OF CPK ISOENZYMES THAT THE ISOENZYME WHICH WAS PREDOMINANT IN BOTH GROUPS OF WOMEN WAS THE SKELETAL MUSCLE TYPE (MM) OF 93-100%. WE PROPOSE THE MEASUREMENT OF TOTAL CPK AND ITS ISOENZYMES AS A ROUTINE METHOD FOR ALL PREGNANT WOMEN, WHO ARE GOING TO RECEIVE ANAESTHESIA, IN ORDER TO PROTECT INDIVIDUALS POSSIBLY SUCCEPTIBLE FOR MALIGNANT HYPERPUREXIA (M.H).

ΜΕΛΕΤΗΘΗΚΑΝ ΔΥΟ ΟΜΑΔΕΣ ΕΓΚΥΩΝ ΓΥΝΑΙΚΩΝ. ΣΤΗ ΠΡΩΤΗ ΟΜΑΔΑ ΟΙ ΓΥΝΑΙΚΕΣ ΓΕΝΝΗΣΑΝ ΜΕ ΦΥΣΙΟΛΟΓΙΚΟ ΤΟΚΕΤΟ, ΕΝΩ ΣΤΗ ΔΕΥΤΕΡΗ ΟΜΑΔΑ, Ο ΤΟΚΕΤΟΣ ΕΓΙΝΕ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ. ΚΑΙ ΣΤΙΣ ΔΥΟ ΟΜΑΔΕΣ ΜΕΤΡΗΘΗΚΕΕ Η ΟΛΙΚΗ CPK ΑΙΜΑΤΟΣ ΚΑΙ ΤΑ ΙΣΟΕΝΖΥΜΑ ΤΗΣ ΠΡΙΝΤΗ ΧΟΡΗΓΗΣΗ ΑΝΑΙΣΘΗΣΙΑΣ ΣΤΗ ΑΡΧΗ ΤΟΥ ΤΟΚΕΤΟΥ ΚΑΘΩΣ ΚΑΙ ΜΕΤΑ ΤΗ ΧΟΡΗΓΗΣΗ ΑΝΑΙΣΘΗΣΙΑΣ ΟΤΑΝ ΤΕΛΕΙΩΝΕ Ο ΤΟΚΕΤΟΣ. Η ΜΕΤΡΗΣΗ ΤΗΣ CPK ΕΓΙΝΕ ΜΕ ΚΙΝΗΤΙΚΗ ΜΕΘΟΔΟ ΜΕ ΤΟ ΑΝΤΙΔΡΑΣΤΗΡΙΟ ΤΗΣ S.KI ΕΝΩ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΕ Η ΗΛΕΚΤΡΟΦΟΡΗΤΙΚΗ ΜΕΘΟΔΟΣ ΤΗΣ HELENA. ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΒΡΕΘΗΚΕ ΟΤΙ ΥΠΑΡΧΕΙ ΣΤΑΤΙΣΤΙΚΑ ΣΗΜΑΝΤΙΚΗ ΔΙΑΦΟΡΑ ΣΤΗ ΜΕΣΗ ΤΙΜΗ CPK ΟΡΟΥ ΠΡΙΝ ΤΗ ΧΟΡΗΓΗΣΗ ΑΝΑΙΣΘΗΣΙΑΣ, ΑΠΟ ΤΗ ΜΕΣΗ ΤΙΜΗ CPK ΜΕΤΑ ΤΗ ΧΟΡΗΓΗΣΗ ΑΝΑΙΣΘΗΣΙΑΣ ΚΑΙ ΣΤΑΔΥΟ ΕΙΔΗ ΤΟΥ ΤΟΚΕΤΟΥ. ΕΠΙΣΗΣ ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ Η ΜΕΣΗ ΠΟΣΟΤΗΤΑ ΟΛΙΚΗΣ CPK ΟΡΟΥ ΣΤΟΝ ΦΥΣΙΟΛΟΓΙΚΟ ΑΥΤΟΜΑΤΟ ΤΟΚΕΤΟ ΕΙΝΑΙ ΜΕΓΑΛΥΤΕΡΗ ΑΠΟ ΕΚΕΙΝΗ ΣΤΗ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ, ΑΝΕΞΑΡΤΗΤΑ ΤΟΥ ΕΑΝ ΕΙΧΑΜΕ ΠΑΡΕΙ ΤΟ ΔΕΙΓΜΑ ΑΙΜΑΤΟΣ ΠΡΙΝ 'Η ΜΕΤΑ ΤΗ ΧΟΡΗΓΗΣΗΑΝΑΙΣΘΗΣΙΑΣ. ΤΕΛΟΣ ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ CPK ΦΑΝΗΚΕ ΟΤΙ ΤΟ ΙΣΟΕΝΖΥΜΟ ΠΟΥ ΕΠΙΚΡΑΤΟΥΣΕ ΚΑΙ ΣΤΙΣ ΔΥΟ ΟΜΑΔΕΣ ΤΩΝ ΓΥΝΑΙΚΩΝ ΗΤΑΝ ΤΟ ΙΣΟΕΝΖΥΜΟ ΣΚΕΛΕΤΙΚΟΥ ΜΥΙΚΟΥ ΤΥΠΟΥ (ΜΜ) ΣΕ ΠΟΣΟΣΤΟ 93- 100%. ΤΗ ΜΕΤΡΗΣΗ ΟΛΙΚΗΣ CPK ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΠΡΟΤΕΙΝΟΥΜΕ ΣΑΝ ΜΕΘΟΔΟ ΡΟΥΤΙΝΑΣ Σ'ΟΛΕΣ ΤΙΣ ΕΓΚΥΕΣ ΓΥΝΑΙΚΕΣ ΠΟΥ ΠΡΟΚΕΙΤΑΙ ΝΑ ΤΟΥΣ ΧΟΡΗΓΗΘΕΙ ΑΝΑΙΣΘΗΣΙΑ, ΜΕ ΣΚΟΠΟ ΝΑ ΠΡΟΦΥΛΑΞΟΥΜΕ ΑΤΟΜΑ ΠΙΘΑΝΩΣ ΕΥΑΙΣΘΗΤΑ ΓΙΑ ΚΑΚΟΗΘΗ ΥΠΕΡΠΥΡΕΞΙΑ (Μ.Η).

Subjects/Keywords: Εγκυμοσύνη; Ισοένζυμα; Καισαρική τομή; ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗ ΟΡΟΥ; ΤΟΚΕΤΟΙ; CAESARIUM SECTION; CPK SERUM; Delivery; Isoenzymes; Pregnancy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ΣΙΑΦΑΚΑ, . �. (1985). ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/0388

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ΣΙΑΦΑΚΑ, ΙΩΑΝΝΑ. “ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ.” 1985. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 05, 2021. http://hdl.handle.net/10442/hedi/0388.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ΣΙΑΦΑΚΑ, ΙΩΑΝΝΑ. “ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ.” 1985. Web. 05 Mar 2021.

Vancouver:

ΣΙΑΦΑΚΑ �. ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 1985. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10442/hedi/0388.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ΣΙΑΦΑΚΑ �. ΜΕΤΑΒΟΛΕΣ ΤΗΣ ΟΛΙΚΗΣ ΚΡΕΑΤΙΝΟΦΩΣΦΟΚΙΝΑΣΗΣ ΟΡΟΥ ΚΑΙ ΤΩΝ ΙΣΟΕΝΖΥΜΩΝ ΤΗΣ ΥΠΟ ΤΗΝ ΕΠΙΔΡΑΣΗ ΑΝΑΙΣΘΗΣΙΟΛΟΓΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΦΥΣΙΟΛΟΓΙΚΟΥ ΤΟΚΕΤΟΥ ΚΑΙ ΤΟΥ ΤΟΚΕΤΟΥ ΜΕ ΚΑΙΣΑΡΙΚΗ ΤΟΜΗ. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 1985. Available from: http://hdl.handle.net/10442/hedi/0388

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade de Brasília

18. Ana Luisa Miranda-Vilela. Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB).

Degree: 2009, Universidade de Brasília

URL: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=4788

► O consumo diário de antioxidantes naturais protege contra danos oxidativos causados por espécies reativas de oxigênio (ERO) e pode reduzir o risco de câncer, aterosclerose… (more)

▼ O consumo diário de antioxidantes naturais protege contra danos oxidativos causados por espécies reativas de oxigênio (ERO) e pode reduzir o risco de câncer, aterosclerose e outras doenças degenerativas. O treinamento físico induz adaptações benéficas, mas exercícios extenuantes ou com frequência de treinamento muito elevada aumentam a geração de ERO, resultando em danos oxidativos no DNA e nos tecidos. O pequi (Caryocar brasiliense Camb.) é uma fruta típica do Cerrado Brasileiro, bem conhecida na culinária regional e usada na medicina popular para tratar várias enfermidades. Sua polpa contém diversos antioxidantes como carotenóides, vitamina C e compostos fenólicos, e sua composição de ácidos graxos é representada principalmente pelos ácidos oléico (51,37 a 55,87%) e palmítico (35,17 a 46,79%). O objetivo deste estudo foi investigar os efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do pequi, através de estudos in vivo em camundongos e atletas humanos (corredores de rua). Os testes pré-clínicos e toxicológicos em camundongos mostraram que os extratos não tiveram efeito clastogênico ou genotóxico sobre as células e ambos protegeram os animais contra danos oxidativos no DNA induzidos por bleomicina ou ciclofosfamida, dois fármacos antineoplásicos. Entretanto, o efeito protetor dependeu da dose. O teste de TBARS, usado para avaliar a atividade antioxidante, mostrou que, nas doses testadas, o extrato aquoso elevou a peroxidação lipídica nos camungongos de ambos os sexos, especialmente nos machos; o extrato orgânico aumentou a peroxidação lipídica apenas nos machos, sem efeitos nas fêmeas. O extrato orgânico (óleo de pequi) foi escolhido para investigar os efeitos antioxidantes contra danos oxidativos induzidos pelo exercício em atletas corredores de rua. Para avaliar se os efeitos antioxidantes do óleo de pequi foram influenciados pelos genótipos das enzimas antioxidantes e da haptoglobina (Hp), foram investigados os polimorfismos dos genes Mn-SOD (��Val9Ala), CAT (��21A/T), GPX1 (Pro198Leu) e Hp. As avaliações foram feitas após corridas ao ar livre em terreno plano, antes e depois da ingestão de 400mg de óleo de pequi em cápsulas durante 14 dias. A pressão arterial dos voluntários foi checada antes das corridas. Após as duas corridas, foram colhidas amostras de sangue e essas foram submetidas ao teste do cometa, teste TBARS, hemograma, lipidograma pós-prandial e análises bioquímicas de creatina-fosfoquinase (CPK), transaminase glutâmica-oxalacética (TGO), transaminase glutâmica-pirúvica (TGP), proteína Creativa ultra-sensível (PCR-US). Os resultados dos testes de TGO, TGP e cometa indicaram influência do sexo, e uma redução significativa de danos após o tratamento com óleo de pequi foi observada no grupo de mulheres para TGO e TGP e em ambos os sexos para o teste do cometa. Para esses marcadores, também houve influência do genótipo Mn-SOD, cuja frequência mais alta de heterozigotos foi relacionada a menores danos no DNA e nos tecidos, além de exibirem melhor… Advisors/Committee Members: Silviene Fabiana de Oliveira, Luzitano Brandão Ferreira, César Koppe Grisólia, Dâmaris Silveira, Elza Tiemi Sakamoto Hojo.

Subjects/Keywords: efeito antigenotóxico; �; postprandial lipid profile; efeito antioxidante; hemograma; índices hematimétricos (VCM, HCM, MHCM e RDW); creatina-fosfoquinase (CPK); transaminase glutâmicaoxalacética (TGO); transaminase glutâmica-pirúvica (TGP); proteína C-reativa ultra-sensível (PCRUS); teste de TBARS; �; CIENCIAS BIOLOGICAS; Caryocar brasiliense Camb.; antioxidant effect; comet assay; hemogram; Caryocar brasiliense Camb.; 21A/T), GPX1 (Pro198Leu) e haptoglobina; hematimetric indexes (MCV, MCH, MCHC and RDW); Mn-SOD (�; TBARS assay; �; antigenotoxic effect; creatine phosphokinase (CPK), glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), high sensitivity C-reactive protein (hs-CRP); Val9Ala), CAT (�; �; 21A/T), GPX1 (Pro198Leu) and haptoglobin genes polymorphisms; efeito cardioprotetor; teste do cometa; perfil lipídico pós-prandial; Val9Ala), CAT (�; polimorfismos dos genes Mn-SOD (�; protective cardiovascular effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miranda-Vilela, A. L. (2009). Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB). (Thesis). Universidade de Brasília. Retrieved from http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=4788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Miranda-Vilela, Ana Luisa. “Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB).” 2009. Thesis, Universidade de Brasília. Accessed March 05, 2021. http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=4788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Miranda-Vilela, Ana Luisa. “Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB).” 2009. Web. 05 Mar 2021.

Vancouver:

Miranda-Vilela AL. Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB). [Internet] [Thesis]. Universidade de Brasília; 2009. [cited 2021 Mar 05]. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=4788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miranda-Vilela AL. Avaliação dos efeitos antigenotóxicos, antioxidantes e farmacológicos de extratos da polpa do fruto do pequi (Caryocar brasiliense CAMB). [Thesis]. Universidade de Brasília; 2009. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=4788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

19. Valmonte, Gardette. Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members .

Degree: AUT University

URL: http://hdl.handle.net/10292/10577

► Agricultural productivity and food security are declining globally, because of factors such as climate change, crop disease, natural calamities, population growth and pollution. Research on… (more)

▼ Agricultural productivity and food security are declining globally, because of factors such as climate change, crop disease, natural calamities, population growth and pollution. Research on how to improve plant stress tolerance, disease resistance and crop productivity is paramount in preparing for future agro-environmental difficulties brought about by a changing world. Calcium-dependent protein kinases (CPKs) are plant proteins that directly bind calcium ions before phosphorylating substrates involved in osmosis, hormone response, stress and pathogen signalling pathways. CPKs are considered as ‘hubs’ in plant signalling; members of this large multigene family may function redundantly or complementarily to multiple stresses and stimuli. This research project aimed to answer three questions about the functional diversification and specificity of CPKs. Firstly, how did CPKs diversify and what is the most conserved CPK group in plants? Secondly, what is the role of the most conserved CPKs in plant stress and pathogen responses? Lastly, what influences CPK functional specificity? A comprehensive genome-wide phylogenetic analysis of CPKs from algae to higher plants showed that CPKs diversified in parallel with the transition of plants into terrestrial life, possibly providing support to plants in response to the stress of this transition; and that the most conserved members of this gene family in plants are those that belong to Group IIb. In Arabidopsis, CPKs that belong to this group are AtCPK3, 17 and 34. AtCPK3 and its orthologues (Group IIb.1) in rice and kiwifruit change in transcript accumulation in response to most abiotic stresses and pathogens such as Botrytis cinerea, Pseudomonas syringae, and various plant viruses, as inferred from meta-analysis of publicly available transcript data and as validated from biological experiments carried out in this project. Knocking out or overexpressing AtCPK3 in Arabidopsis and AcCPK16 in kiwifruit appeared to change the way the limited number of experimental plants respond to stress and pathogens. In Arabidopsis, overexpressors were slightly more tolerant to drought, bacterial, fungal and viral infections, whereas knockouts had little difference or were slightly more susceptible to WT. In kiwifruit, overexpressors were slightly more tolerant to drought and more susceptible to fungal infections, whereas knockouts had little difference or were slightly more susceptible to WT. AtCPK17 and 34 and their orthologues in rice and kiwifruit (Group IIb.2) were only expressed in floral tissue and mainly function in pollen development. Gene structure and predicted protein structure analysis of Group IIb CPKs in Arabidopsis and rice identified promoter regions and several protein motifs correlated to CPK function. Seed and pollen germination assays showed some degree of similarity in responses among AtCPK3 and AtCPK34 single overexpressors, suggesting that tissue localisation influences CPK gene function. Gene structure, several protein motifs and tissue localisation, all… Advisors/Committee Members: Higgins, Colleen (advisor), MacDiarmid, Robin (advisor).

Subjects/Keywords: Calcium signalling; plant stress; biotic and abiotic stress; plant pathogens; plant pathogen interactions; molecular indicators; CPK gene family; Calcium-dependent protein kinases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valmonte, G. (n.d.). Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/10577

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valmonte, Gardette. “Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members .” Thesis, AUT University. Accessed March 05, 2021. http://hdl.handle.net/10292/10577.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valmonte, Gardette. “Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members .” Web. 05 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Valmonte G. Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members . [Internet] [Thesis]. AUT University; [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10292/10577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Valmonte G. Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members . [Thesis]. AUT University; Available from: http://hdl.handle.net/10292/10577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

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