subject:(Corneal nerves)

University of New South Wales

1. Mandathara Sudharman, Preeji. CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS.

Degree: Optometry & Vision Science, 2017, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/58592 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46316/SOURCE02?view=true

► This thesis aimed to evaluate changes in corneal nerves, sensitivity, tear proteins and neuropeptides and their associations with other variables such as ocular symptoms, tear… (more)

▼ This thesis aimed to evaluate changes in corneal nerves, sensitivity, tear proteins and neuropeptides and their associations with other variables such as ocular symptoms, tear osmolarity, tear volume and ocular surface health in keratoconus. Corneal sensitivity was measured with 0.08mm nylon filament of a Cochet-Bonnet aesthesiometer, corneal nerves were mapped using laser in vivo confocal microscopy and concentrations of total protein, substance P (SP), calcitonin gene related peptide (CGRP) and lactoferrin in basal tears were quantified using enzyme immuno-assays in a cross-sectional study of keratoconus subjects.This study demonstrated that corneal sensitivity and sub-basal nerve fibre density were reduced, tortuosity of nerve fibres was increased and concentrations of total tear protein and lactoferrin were reduced in keratoconus. There was an inverse relation between tear lactoferrin and neuropeptides SP and CGRP. Increased corneal sensitivity (reduced threshold) was associated with increased ocular symptoms whereas reduced corneal sensitivity was associated with increased corneal staining. Contact lens wear affected corneal sensitivity, corneal nerves and concentration of total tear protein. Epithelial dendritic cells were common in the central cornea and their density and morphology were associated with nerve tortuosity. Reduced corneal sensitivity, increased tortuosity of corneal nerves, corneal scarring and reduced concentration of tear lactoferrin were associated with better tolerance to contact lens wear.This study suggests that changes in corneal nerves and sensitivity could be responsible for changes at the ocular surface and in tear protein concentrations, which may affect the success of management options for keratoconus such as contact lens wear. The presence of mature epithelial dendritic cells in the central cornea and reduction in the anti-inflammatory tear protein lactoferrin, and a negative association between concentrations of tear lactoferrin and neuropeptides, may provide evidence for inflammation in keratoconus. Overall, these results indicate that keratoconus may show characteristics consistent with neuro-degenerative diseases where inflammation plays a significant role. While corneal collagen cross linking (CXL) may halt the progression of keratoconus, the procedure may not reverse the corneal nerve damage and biochemical changes in the tears in keratoconus subjects. The persistence of significant number of epithelial dendritic cells following CXL, suggest a chronic inflammation which may adversely impact the success of future management options such as corneal transplantation. Advisors/Committee Members: Willcox, Mark, Optometry & Vision Science, Faculty of Science, UNSW, Stapleton, Fiona, Optometry & Vision Science, Faculty of Science, UNSW.

Subjects/Keywords: Corneal sensitivity; Keratoconus; Corneal nerves; Tear neuropeptides

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APA (6^th Edition):

Mandathara Sudharman, P. (2017). CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/58592 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46316/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Mandathara Sudharman, Preeji. “CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS.” 2017. Doctoral Dissertation, University of New South Wales. Accessed March 09, 2021. http://handle.unsw.edu.au/1959.4/58592 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46316/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Mandathara Sudharman, Preeji. “CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS.” 2017. Web. 09 Mar 2021.

Vancouver:

Mandathara Sudharman P. CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS. [Internet] [Doctoral dissertation]. University of New South Wales; 2017. [cited 2021 Mar 09]. Available from: http://handle.unsw.edu.au/1959.4/58592 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46316/SOURCE02?view=true.

Council of Science Editors:

Mandathara Sudharman P. CORNEAL NERVES, SENSITIVITY AND TEAR NEUROPEPTIDES IN KERATOCONUS. [Doctoral Dissertation]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/58592 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46316/SOURCE02?view=true

University of New South Wales

2. Pebbeti, Roopa Reddy S. Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery.

Degree: Optometry & Vision Science, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/53479 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12174/SOURCE02?view=true

► In addition to their sensory role, corneal nerves serve as a protective and trophic function in the cornea. Any alterations to this structure, such as… (more)

▼ In addition to their sensory role, corneal nerves serve as a protective and trophic function in the cornea. Any alterations to this structure, such as those occurring during refractive surgery, may have significant implications for the maintenance of a healthy cornea. This study aimed to investigate 1) the morphological and functional changes in the cornea at two different locations (central and temporal), 2) symptomatology and 3) the possible relationship between specific neuroproteins detected in tears, and changes in structure and functional factors of the corneal nerves after various refractive surgery techniques including LASIK Mechanical Microkeratome (MM), LASIK FemtoSecond (FS), Photorefractive Keratectomy. Comparisons were made with age and gender matched controls. All subjects were followed for up to 3 months.Corneal nerve morphology and its function were severely altered after the surgery and these changes were evident in both central and temporal regions of the cornea. In all the surgical groups, corneal mechanical sensitivity recovered to pre-operative levels after three months whereas corneal nerve morphology did not return to its baseline values. This may suggest a degree of redundancy in the corneal sub epithelial nerve plexus. There was no difference between LASIK with MM and LASIK with FS in terms of the amount of nerve regeneration and its function. Most of the subjects exhibited increased symptoms of discomfort at three months after the surgery and there was an association between the signs and symptoms of ocular discomfort. In addition, differences were demonstrated in the clinical signs of ocular discomfort among various surgical groups, with patients undergoing PRK exhibiting fewer clinical signs of discomfort. This difference might be attributed in part to the higher expression of NGF levels measured after PRK in this study. All together, the evidence obtained during the course of this study suggests that there is a connection between alterations in the corneal nerve structure, persisting corneal staining, increased neurotrophic effect of NGF, and increased ocular discomfort three months after surgery. The processes underlying the increased symptoms of discomfort following refractive surgery might be influenced by changes in tear film such as modulation of NGF, changes in corneal epithelial integrity and altered nerve fibre density. Advisors/Committee Members: Prof. Deborah, Sweeney, University of Western Sydney, Dr. Eric B, Papas, Optometry & Vision Science, Faculty of Science, UNSW.

Subjects/Keywords: Neuroproteins; Corneal Nerves; Refractive Surgery; Corneal Sensitivity

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APA (6^th Edition):

Pebbeti, R. R. S. (2012). Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53479 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12174/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Pebbeti, Roopa Reddy S. “Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery.” 2012. Doctoral Dissertation, University of New South Wales. Accessed March 09, 2021. http://handle.unsw.edu.au/1959.4/53479 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12174/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Pebbeti, Roopa Reddy S. “Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery.” 2012. Web. 09 Mar 2021.

Vancouver:

Pebbeti RRS. Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2021 Mar 09]. Available from: http://handle.unsw.edu.au/1959.4/53479 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12174/SOURCE02?view=true.

Council of Science Editors:

Pebbeti RRS. Morphological and Functional Factors of Corneal Nerves Following Refractive Surgery. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/53479 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12174/SOURCE02?view=true

University of Manchester

3. Kalteniece, Alise. ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY.

Degree: 2020, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323415

► Corneal confocal microscopy (CCM) has been utilised to study corneal nerves, epithelium, stroma and the endothelium in a variety of normal and disease states and… (more)

Subjects/Keywords: corneal confocal microscopy; corneal nerves; diabetic peripheral neuropathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kalteniece, A. (2020). ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323415

Chicago Manual of Style (16^th Edition):

Kalteniece, Alise. “ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 09, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323415.

MLA Handbook (7^th Edition):

Kalteniece, Alise. “ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY.” 2020. Web. 09 Mar 2021.

Vancouver:

Kalteniece A. ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 09]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323415.

Council of Science Editors:

Kalteniece A. ESTABLISHING CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE ASSESSMENT OF DIABETIC PERIPHERAL NEUROPATHY. [Doctoral Dissertation]. University of Manchester; 2020. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323415

Queensland University of Technology

4. Pritchard, Nicola. Corneal nerve structure and function as markers of diabetic neuropathy.

Degree: 2012, Queensland University of Technology

URL: https://eprints.qut.edu.au/52722/

► Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation.… (more)

▼ Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation. The accurate detection, characterisation and quantification of this condition are important in order to define at-risk patients, anticipate deterioration, monitor progression and assess new therapies. This thesis evaluates novel corneal methods of assessing diabetic neuropathy. Over the past several years two new non-invasive corneal markers have emerged, and in cross-sectional studies have demonstrated their ability to stratify the severity of this disease. Corneal confocal microscopy (CCM) allows quantification of corneal nerve parameters and non-contact corneal aesthesiometry (NCCA), the presumed functional correlate of corneal structure, assesses the sensitivity of the cornea. Both these techniques are quick to perform, produce little or no discomfort for the patient, and with automatic analysis paradigms developed, are suitable for clinical settings. Each has advantages and disadvantages over established techniques for assessing diabetic neuropathy. New information is presented regarding measurement bias of CCM images, and a unique sampling paradigm and associated accuracy determination method of combinations is described. A novel high-speed corneal nerve mapping procedure has been developed and application of this procedure in individuals with neuropathy has revealed regions of sub-basal nerve plexus that dictate further evaluation, as they appear to show earlier signs of damage than the central region of the cornea that has to date been examined. The discriminative capacity of corneal sensitivity measured by NCCA is revealed to have reasonable potential as a marker of diabetic neuropathy. Application of these new corneal markers for longitudinal evaluation of diabetic neuropathy has the potential to reduce dependence on more invasive, costly, and time-consuming assessments, such as skin biopsy.

Subjects/Keywords: repeatability; corneal nerves; diabetes; neuropathy; non-contact corneal aesthesiometry; corneal sensitivity; neuropathy disability score; ophthalmic markers; corneal confocal microscopy; corneal markers; diabetic neuropathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pritchard, N. (2012). Corneal nerve structure and function as markers of diabetic neuropathy. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/52722/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pritchard, Nicola. “Corneal nerve structure and function as markers of diabetic neuropathy.” 2012. Thesis, Queensland University of Technology. Accessed March 09, 2021. https://eprints.qut.edu.au/52722/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pritchard, Nicola. “Corneal nerve structure and function as markers of diabetic neuropathy.” 2012. Web. 09 Mar 2021.

Vancouver:

Pritchard N. Corneal nerve structure and function as markers of diabetic neuropathy. [Internet] [Thesis]. Queensland University of Technology; 2012. [cited 2021 Mar 09]. Available from: https://eprints.qut.edu.au/52722/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pritchard N. Corneal nerve structure and function as markers of diabetic neuropathy. [Thesis]. Queensland University of Technology; 2012. Available from: https://eprints.qut.edu.au/52722/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

5. Meyer, Jenna. Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/19491

► INTRODUCTION: The cornea forms the anterior-most barrier of the eye, consisting of a non-keratinized pseudostratified squamous epithelium, a collagen-based stroma, and an endothelium. It is… (more)

▼ INTRODUCTION: The cornea forms the anterior-most barrier of the eye, consisting of a non-keratinized pseudostratified squamous epithelium, a collagen-based stroma, and an endothelium. It is completely avascular, yet the most densely innervated structure in the human body. The sensory nerves project from the ophthalmic branch of the trigeminal cranial nerve into the limbal/stromal interface. From there, the nerves branch and ascend into Bowman’s membrane, a basal lamina delineating the epithelium from the stroma, and project into the epithelium as free nerve endings. Injury to the corneal epithelium can potentially lead to impaired vision if the wound healing process is not properly initiated. Immediately after injury, nucleotides such as ATP are released and bind to purinergic receptors known to be located in epithelial cell membranes, thereby initiating epithelial cell migration to close the wound. Malfunctions in the interactions between the corneal nerves and their epithelial counterparts during the wound healing process are thought to contribute to the attenuated wound healing characteristic of diabetes. However, the precise nature of these interactions, how they facilitate wound healing, and how they are impaired in diabetes, is not well understood. OBJECTIVES: Previously, our lab has shown that a member of purinergic family receptors (P2X7) is localized in the basal epithelial cells and becomes relocated to the leading edge of the wound after injury. When the relocation is inhibited, migration is attenuated. Additionally, it is known that diabetic mouse models display slower wound healing rates. The present study has three aims: (1) to replicate the characteristic sub-basal whorl organization of the corneal nerves in organ-cultured corneas; (2) to elucidate the connections between patterns of corneal innervation and purinergic receptor expression; and (3) to understand how these patterns interact to facilitate normal wound healing and how these interactions are disrupted in a diabetic model. METHODS: Our approach was to use immunohistochemistry of dissected mouse and to visualize the tissue using confocal microscopy. Sensory innervation profiles from diet induced obesity (DIO) mouse corneas and their wildtype C57Bl6 counterparts were compared in unwounded and wounded tissue. To image the nerves a methanol fixation protocol was optimized to examine the sub-basal plexus and the apical nerves. Corneas were dissected, stained with beta III-tubulin, which identifies nerves, and with an antibody to the P2X7 purinergic receptor, which is expressed in the epithelium and nerves. Trephine induced epithelial abrasion injuries were made on separate DIO and control models to compare re-epithelialization and re-innervation between the diseased and healthy states. Corneas were imaged using a Zeiss LSM 700 laser scanning confocal microscope and optical images were taken through the cornea over a distance averaging 115 microns. Corneas were imaged using a macro tiling plugin, stitching 3x3 optical z-stacks into composite…

Subjects/Keywords: Biochemistry; P2X7; Cornea; Corneal nerves; Epithelium; Purinergic receptor; Wound healing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meyer, J. (2016). Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19491

Chicago Manual of Style (16^th Edition):

Meyer, Jenna. “Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes.” 2016. Masters Thesis, Boston University. Accessed March 09, 2021. http://hdl.handle.net/2144/19491.

MLA Handbook (7^th Edition):

Meyer, Jenna. “Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes.” 2016. Web. 09 Mar 2021.

Vancouver:

Meyer J. Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2144/19491.

Council of Science Editors:

Meyer J. Eye-solating corneal innervation profiles to examine epithelial wound healing in a model of type II diabetes. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19491

University of New South Wales

6. Tummanapalli, Shyam Sunder. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.

Degree: Optometry & Vision Science, 2020, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

► Background: Corneal nerve fibers express diffusible, trophic neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) into tears in response to neurogenic inflammation. Impaired… (more)

▼ Background: Corneal nerve fibers express diffusible, trophic neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) into tears in response to neurogenic inflammation. Impaired corneal nerve fibers have been proposed as early indicators of diabetic peripheral neuropathy (DPN). However, the changes that occur in the concentration of these neuropeptides and their relationship with peripheral neuropathy in the diabetic cohort has not been explored.Aim: To demonstrate the changes the concentrations of substance P and CGRP in tears as a result of corneal denervation in diabetes and their association with severity of DPN. Methods: The concentrations of substance P and CGRP in flush tears were measured by enzyme-linked immunosorbent assay. Corneal nerve fibers were assessed using corneal confocal microscopy. Motor nerve axonal excitability tests were conducted to assess axonal function.Results: Age was identified as a confounding factor and controlled in all subsequent studies. Corneal nerve fiber loss was associated with early markers of axonal dysfunction and severity of neuropathy in type 1 diabetes, suggesting that corneal nerve loss is a generalized neuropathic process. There was a significant reduction in the concentration of substance P in tears in people with type 1 diabetic neuropathy. The concentration of substance P in tears was associated with corneal nerve loss and with the severity of peripheral neuropathy in type 1 diabetes. In type 2 diabetes, there was no difference in neuropeptides between groups, regardless of neuropathic status. In both type 1 and type 2 diabetes, corneal nerve parameters were significantly decreased in DPN. Corneal confocal microscopy had a better diagnostic performance than the nerve excitability measures for detecting DPN in a cohort of participants with type 1 and type 2 diabetes. Tear film substance P concentration had a relatively good diagnostic efficiency in the assessment of DPN and may be used as a potential proxy marker for peripheral neuropathy in type 1 diabetes, but not in type 2 diabetes. The co-existence of renal dysfunction with diabetes does have an added detrimental effect on corneal small nerve fibers.Conclusion: The ocular surface can indeed be a useful means to detect peripheral neuropathic status in diabetes. The measurement of tear film substance P offers significant promise in the detection of DPN. Advisors/Committee Members: Markoulli, Maria, Optometry & Vision Science, Faculty of Science, UNSW, Willcox, Mark, Optometry & Vision Science, Faculty of Science, UNSW, Poynten, Ann, Department of Endocrinology, Prince of Wales Hospital, Sydney.

Subjects/Keywords: Tear neuropeptide; Diabetic peripheral neuropathy; Corneal confocal microscopy; Total neuropathy score; Type 2 diabetes; Tear film; Corneal nerves; Nerve excitability studies; Substance P; Calcitonin gene-related peptide; Chronic kidney disease; Flush tears; Inferior whorl; Fractal dimension; Type 1 diabetes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tummanapalli, S. S. (2020). Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Doctoral Dissertation, University of New South Wales. Accessed March 09, 2021. http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Tummanapalli, Shyam Sunder. “Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy.” 2020. Web. 09 Mar 2021.

Vancouver:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Internet] [Doctoral dissertation]. University of New South Wales; 2020. [cited 2021 Mar 09]. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true.

Council of Science Editors:

Tummanapalli SS. Evaluation of corneal nerves and tear neuropeptides in diabetic peripheral neuropathy. [Doctoral Dissertation]. University of New South Wales; 2020. Available from: http://handle.unsw.edu.au/1959.4/65060 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:63698/SOURCE02?view=true

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