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University of Bath
1.
Scott, C. Daniel.
Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation.
Degree: PhD, 2020, University of Bath
URL: https://researchportal.bath.ac.uk/en/studentthesis/bridging-the-gap-in-sustainable-continuous-chemicals-manufacture-integrating-upstream-synthesis-and-downstream-crystallisation(7c98e99c-576e-49c0-a173-609b266b6dba).html 
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809723
► Continuous manufacturing (CM) is effective for sustainable chemical manufacture, but production of pharmaceuticals and fine chemicals requires complex, multi-step procedures often carried out in batch.…
(more)
▼ Continuous manufacturing (CM) is effective for sustainable chemical manufacture, but production of pharmaceuticals and fine chemicals requires complex, multi-step procedures often carried out in batch. Gaps in the CM supply chain, such as between upstream flow synthesis and downstream continuous crystallisation form a major bottleneck in the take-up of CM. The motivation for the research presented in this thesis was to demonstrate integrated CM of pharmaceuticals and multi-component complexes. The oximation of 4-hydroxyacetophenone (4HAP) to 4-hydroxyacetophenone oxime (4- HAPO) and subsequent Beckmann rearrangement of 4HAPO to paracetamol (PCM) was investigated. A one-pot method was transferred to flow using a packed bed column, but leaching into the feed limited downstream integration. A two-step approach was transferred into flow to give 4HAPO and PCM respectively. Synthesis of 4HAPO was integrated with a compact flow crystalliser with partial success, while a semi-batch approach showed 4HAPO could be directly crystallised from the flow synthesis effluent. The catalytic flow hydration of pyrazinecarbonitrile (PyCN) to the drug pyrazinamide (PZA) was integrated with the segmented flow kinetically regulated automated input crystalliser (KRAIC). A cooling step introduced controlled nucleation and resulted in a five-fold reduction in crystal size. The crystallisation technique selectively formed the γ-PZA polymorph from the aqueous solution without the need for additives. Production of multi-component complexes, 4-bromo-2-methylaniline (4Br2MA):3,5-dinitrobenzoic acid (35DNBA) and 4-iodo-2-methylaniline (4I2MA):35DNBA, was investigated using antisolvent crystallisation. Crystallisation of 4Br2MA:35DNBA was transferred into a segmented flow crystalliser and off-line isolation of the precipitate allowed characterisation of 4Br2MA:35DNBA crystals. A novel form of 4I2MA:35DNBA was isolated and characterised from batch crystallisation experiments. Thermal analysis of the thermochromic behaviour of the cocrystals showed that the single-crystal-to- single-crystal (SCSC) phase transition may be enabled by water in the bulk sample. Two flow crystallisers (a tubular mixer reactor and a periodic withdrawal, continuous stirred tank reactor (CSTR) system) were evaluated for production of a commercial active pharmaceutical ingredient (API) salt. Crystallisation in the tubular mixer reactor was effective only for short periods at high velocity flow rates. Crystallisation in the CSTRs successfully operated for twelve residence times (RTs); with a 70 % yield of the API salt. The API salt formed spherical agglomerates in flow which showed higher uniformity and lower cake resistance compared to the batch sample.
Subjects/Keywords: Continuous flow reactor; Crystallisation; Continuous crystallisation; Process development; Flow Synthesis
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APA (6th Edition):
Scott, C. D. (2020). Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation. (Doctoral Dissertation). University of Bath. Retrieved from https://researchportal.bath.ac.uk/en/studentthesis/bridging-the-gap-in-sustainable-continuous-chemicals-manufacture-integrating-upstream-synthesis-and-downstream-crystallisation(7c98e99c-576e-49c0-a173-609b266b6dba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809723
Chicago Manual of Style (16th Edition):
Scott, C Daniel. “Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation.” 2020. Doctoral Dissertation, University of Bath. Accessed January 20, 2021.
https://researchportal.bath.ac.uk/en/studentthesis/bridging-the-gap-in-sustainable-continuous-chemicals-manufacture-integrating-upstream-synthesis-and-downstream-crystallisation(7c98e99c-576e-49c0-a173-609b266b6dba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809723.
MLA Handbook (7th Edition):
Scott, C Daniel. “Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation.” 2020. Web. 20 Jan 2021.
Vancouver:
Scott CD. Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation. [Internet] [Doctoral dissertation]. University of Bath; 2020. [cited 2021 Jan 20].
Available from: https://researchportal.bath.ac.uk/en/studentthesis/bridging-the-gap-in-sustainable-continuous-chemicals-manufacture-integrating-upstream-synthesis-and-downstream-crystallisation(7c98e99c-576e-49c0-a173-609b266b6dba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809723.
Council of Science Editors:
Scott CD. Bridging the gap in sustainable continuous chemicals manufacture : integrating upstream synthesis and downstream crystallisation. [Doctoral Dissertation]. University of Bath; 2020. Available from: https://researchportal.bath.ac.uk/en/studentthesis/bridging-the-gap-in-sustainable-continuous-chemicals-manufacture-integrating-upstream-synthesis-and-downstream-crystallisation(7c98e99c-576e-49c0-a173-609b266b6dba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809723
Cornell University
2.
Opalka, Suzanne.
Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors.
Degree: PhD, Chemistry and Chemical Biology, 2012, Cornell University
URL: http://hdl.handle.net/1813/31490
► This dissertation discusses the development of complex catalytic systems in both batch and flow reactors using either organocatalysts or transition metal complexes with the future…
(more)
▼ This dissertation discusses the development of complex catalytic systems in both batch and
flow reactors using either organocatalysts or transition metal complexes with the future goal of developing multicatalyst cascade reactions. The work begins by providing a background of the various uses of multicatalyst systems in cascade reactions in both batch and
flow. The observations gleaned from the group's work on the development of a multicatalyst system using a urea catalyst and L-proline in the known [alpha]-aminoxylation reaction spurred the development of a proline derivative/urea catalyst system in the formation of not only [alpha],[beta] and [beta],[gamma] unsaturated enones, but also substituted tetrahydrofuran derivatives. The second chapter illustrates both the scope of the transformation and provides a mechanistic understanding of the system. Then, wanting to transition proline catalyzed reaction to
flow without the use of tethered catalysts or expensive soluble proline derivatives, we developed a new method for the direct use of solid proline. A soluble proline pre-catalyst was generated by passing reagents through a packed-bed of proline that was used in a downstream [alpha]-aminoxylation reaction. The final chapter extends this idea to the direct use of solid copper (I) oxide in the generation of Nheterocyclic carbene complexes. The utility of the carbene complexes was illustrated in the [beta]-borlyation of [alpha],[beta] unsaturated esters.
Advisors/Committee Members: Collum, David B (chair), Coates, Geoffrey (committee member), Dichtel, William Robert (committee member), McQuade, David Tyler (committee member).
Subjects/Keywords: Continuous-flow chemistry; Organocatalysis; packed-bed microreactor
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APA (6th Edition):
Opalka, S. (2012). Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/31490
Chicago Manual of Style (16th Edition):
Opalka, Suzanne. “Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors.” 2012. Doctoral Dissertation, Cornell University. Accessed January 20, 2021.
http://hdl.handle.net/1813/31490.
MLA Handbook (7th Edition):
Opalka, Suzanne. “Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors.” 2012. Web. 20 Jan 2021.
Vancouver:
Opalka S. Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors. [Internet] [Doctoral dissertation]. Cornell University; 2012. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/1813/31490.
Council of Science Editors:
Opalka S. Development Of Catalytic Systems In Batch And Flow Using Dual Organocatalysts And Solid Packed-Bed Reactors. [Doctoral Dissertation]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/31490
University of Ottawa
3.
Plouffe, Patrick.
Micro-Reactor Design for Fast Liquid-Liquid Reactions
.
Degree: 2015, University of Ottawa
URL: http://hdl.handle.net/10393/32875
► Continuous operation presents multiple advantages over batch chemistry, yet its usage in the fine chemical and pharmaceutical industry remains limited due to its complexity. A…
(more)
▼ Continuous operation presents multiple advantages over batch chemistry, yet its usage in the fine chemical and pharmaceutical industry remains limited due to its complexity.
A holistic tool-box approach for process development is presented to facilitate technology transfer. Reaction kinetics and reacting phases were taken into consideration for the selection of the most appropriate reactor module and operating conditions.
A micro-reactor was then more specifically developed for fast liquid-liquid reactions. The effect of physical properties was investigated in a serpentine micro-reactor using a reactive liquid-liquid extraction and different organic solvents (n-butanol, n-hexanol, MTBE and toluene). The generated droplets yielded a specific interfacial area of 104-105 m2/m3, compared to ~102 m2/m3 with conventional equipment. Two models were developed to predict the mass transfer rates for other reactive systems.
Further, the effect of geometry was investigated with five different micro-reactors using either curvature-based or obstacle-based micro-mixers. Curvature-based micro-mixers promoted the undesired parallel flow pattern due to stabilizing centrifugal forces, while obstacle-based micro-mixers avoided it.
A scale-up approach was finally proposed on a micro-reactor using an optimized micro-mixer. The mass transfer coefficients in a small-scale (1.5-15 mL/min) and a large-scale (12.5-125 mL/min) systems were compared and demonstrated its validity.
The obtained results allowed the prediction, the optimization, and the scaling of performance for liquid-liquid systems in the context of process development from molecular discovery to clinical trials and pilot scale production.
Subjects/Keywords: Micro-Reactor;
Multiphase;
Continuous Flow;
Pharmaceutical
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APA (6th Edition):
Plouffe, P. (2015). Micro-Reactor Design for Fast Liquid-Liquid Reactions
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/32875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Plouffe, Patrick. “Micro-Reactor Design for Fast Liquid-Liquid Reactions
.” 2015. Thesis, University of Ottawa. Accessed January 20, 2021.
http://hdl.handle.net/10393/32875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Plouffe, Patrick. “Micro-Reactor Design for Fast Liquid-Liquid Reactions
.” 2015. Web. 20 Jan 2021.
Vancouver:
Plouffe P. Micro-Reactor Design for Fast Liquid-Liquid Reactions
. [Internet] [Thesis]. University of Ottawa; 2015. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/10393/32875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Plouffe P. Micro-Reactor Design for Fast Liquid-Liquid Reactions
. [Thesis]. University of Ottawa; 2015. Available from: http://hdl.handle.net/10393/32875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
York University
4.
Chen, Xia.
Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation.
Degree: PhD, Chemistry, 2019, York University
URL: http://hdl.handle.net/10315/35799
► Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization,…
(more)
▼ Continuous microfluidic technology has proven to be a potential competitor with established batch systems for facilitating chemical synthesis and purification, and more amenable to miniaturization, integration, and automation. Nevertheless, combining synthesis, purification and analysis remains a challenge due to the lack of development in efficient
continuous flow purification techniques. An emerging
continuous-
flow purification technique is magnetophoresis, which utilizes surface-functionalized magnetic particles to selectively capture target molecules through specific binding, followed by manipulating the migration of particles through external magnetic force.
This dissertation explores the synthesis of monodisperse core-shell functionalized magnetic nanoparticles composed of a single-core structure, and their application in magnetic manipulation for capture and isolation of targets in the
continuous flow. First, single-cored magnetic nanoparticles with surface functionalities were prepared by coating functional triethoxysilanes onto iron oxide nanoparticles. The morphology, size, and colloidal stability of the resulting functionalized magnetic nanoparticles can be predicted and controlled. Second, a microfluidic device was fabricated from poly(dimethylsiloxane)(PDMS), consisting of two major components, a mixer and a separator (a diagram shown below). In the mixer, target molecules were captured by functionalized magnetic nanoparticles in a T-shape microchannel. Then the magnetic bead-target complex is directed into the separator, where the captured target molecules are magnetically steered out of the matrix while passing through a laminar co-
flow profile. For proof of concept, we used a mixture of toluidine blue O (TBO) and sodium fluorescein as a model target and nontarget, respectively, and carboxyl functionalized magnetic beads as a receptor, leading to the selective complexation of TBO and magnetic beads via electrostatic binding. The device allowed for complete separation of the target from the nontarget molecules with high separation selectivity and efficiency as well as excellent reliability and flexibility.
Advisors/Committee Members: Pietro, William (advisor), Organ, Michael (advisor).
Subjects/Keywords: Chemistry; Magnetic nanoparticles; Continuous flow purification; Microfluidics
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APA (6th Edition):
Chen, X. (2019). Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation. (Doctoral Dissertation). York University. Retrieved from http://hdl.handle.net/10315/35799
Chicago Manual of Style (16th Edition):
Chen, Xia. “Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation.” 2019. Doctoral Dissertation, York University. Accessed January 20, 2021.
http://hdl.handle.net/10315/35799.
MLA Handbook (7th Edition):
Chen, Xia. “Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation.” 2019. Web. 20 Jan 2021.
Vancouver:
Chen X. Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation. [Internet] [Doctoral dissertation]. York University; 2019. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/10315/35799.
Council of Science Editors:
Chen X. Facile Controlled Preparation of Multifunctional Core-Shell Magnetic Nanoparticles and Their Use in Microfluidic Separation. [Doctoral Dissertation]. York University; 2019. Available from: http://hdl.handle.net/10315/35799
University of Manitoba
5.
Devlin, Tanner.
Development of a continuous flow reactor for aerobic granular sludge.
Degree: Civil Engineering, 2019, University of Manitoba
URL: http://hdl.handle.net/1993/34064
► Aerobic granular sludge is an advanced biological process that provides sustainable wastewater treatment. Compared to conventional wastewater treatment processes, aerobic granular sludge exhibits better settling,…
(more)
▼ Aerobic granular sludge is an advanced biological process that provides sustainable wastewater treatment. Compared to conventional wastewater treatment processes, aerobic granular sludge exhibits better settling, higher volumetric loading, reduced chemical and electrical requirements, and less biosolids production. Currently, aerobic granular sludge is only available as a sequencing batch reactor process. Sequencing batch reactors, however, would not be suitable for retrofit at most existing wastewater treatment facilities. Therefore, many facilities would not be able to realize the benefits of aerobic granular sludge unless significant changes to existing infrastructure were made. A more compatible technology, being a
continuous flow reactor, would facilitate the implementation of aerobic granular sludge into existing facilities that would otherwise struggle with sequencing batch reactors.
Thus, the goal of these studies was to develop a
continuous flow reactor for aerobic granular sludge that would be suitable for retrofit into existing wastewater treatment facilities. To attain the goal, several items had to be addressed, including: 1) the suitability of aerobic granular sludge to treat low-strength, municipal wastewater; 2) the importance of hydrodynamic shear force for aerobic granular sludge stability; 3) the role of organic loading rate on aerobic granular sludge stability and performance; 4) the impact of selective wasting on granulation in
continuous flow; and 5) the impact of reactor configuration on granulation in
continuous flow. For more general items, such as suitability for low-strength wastewater and the role of hydrodynamic shear force, lab-scale sequencing batch reactors were used. The remaining tests were carried out in lab- and pilot-scale
continuous flow reactors. Based on the results, design and operational parameters for an aerobic granular sludge-
continuous flow reactor were developed and confirmed to be feasible for the treatment of low-strength, municipal wastewater.
Advisors/Committee Members: Oleszkiewicz, Jan (Civil Engineering) (supervisor), Sears, Keith (Civil Engineering).
Subjects/Keywords: Aerobic granular sludge; Continuous flow; Wastewater treatment
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APA (6th Edition):
Devlin, T. (2019). Development of a continuous flow reactor for aerobic granular sludge. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34064
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Devlin, Tanner. “Development of a continuous flow reactor for aerobic granular sludge.” 2019. Thesis, University of Manitoba. Accessed January 20, 2021.
http://hdl.handle.net/1993/34064.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Devlin, Tanner. “Development of a continuous flow reactor for aerobic granular sludge.” 2019. Web. 20 Jan 2021.
Vancouver:
Devlin T. Development of a continuous flow reactor for aerobic granular sludge. [Internet] [Thesis]. University of Manitoba; 2019. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/1993/34064.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Devlin T. Development of a continuous flow reactor for aerobic granular sludge. [Thesis]. University of Manitoba; 2019. Available from: http://hdl.handle.net/1993/34064
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
6.
Pearce, Benjamin.
Nonthermal plasma synthesis of aluminum nanoparticles.
Degree: M.S.M.E., Mechanical Engineering, 2017, University of Minnesota
URL: http://hdl.handle.net/11299/191241
► Aluminum nanoparticles are an intriguing material because of their high reactivity and high energy density, making them ideal for propellant materials such as rocket fuel.…
(more)
▼ Aluminum nanoparticles are an intriguing material because of their high reactivity and high energy density, making them ideal for propellant materials such as rocket fuel. In addition, nanoaluminum is also a promising abundant, low cost material for plasmonic applications with a plasmonic response that can extend from the visible region of the light spectrum down to ultraviolet wavelengths of light. Nonthermal plasmas are a promising tool for synthesizing nanocrystalline materials without the need for high temperatures or solvents. Their ability to add electrons to the surface of nanoparticles within the plasma helps reduce agglomeration and form aerosols with tighter size distributions than other competing aerosol synthesis techniques. Nanoparticles containing crystalline elemental aluminum were synthesized using a nonthermal plasma containing trimethylaluminum (TMA) vapor, argon and hydrogen gases. The percentage of hydrogen flowing with respect to total gas flow was required to be at least 70% in order to form crystalline aluminum. In addition the ratio of H2 to TMA flow rates needed to be a minimum of 60. 7% of the nanoparticles' aluminum atoms were in elemental aluminum form with the remaining ones in the form of alumina (Al2O3) or an aluminum hydroxide according characterization by air-free X-ray photoelectron spectroscopy. Air-free X-ray diffraction of the nanoparticles indicated the average crystallite size of the elemental aluminum in the particles was on the other of a few nanometers.
Subjects/Keywords: Aluminum nanoparticles; Continuous flow reactor; Nonthermal plasma
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APA (6th Edition):
Pearce, B. (2017). Nonthermal plasma synthesis of aluminum nanoparticles. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/191241
Chicago Manual of Style (16th Edition):
Pearce, Benjamin. “Nonthermal plasma synthesis of aluminum nanoparticles.” 2017. Masters Thesis, University of Minnesota. Accessed January 20, 2021.
http://hdl.handle.net/11299/191241.
MLA Handbook (7th Edition):
Pearce, Benjamin. “Nonthermal plasma synthesis of aluminum nanoparticles.” 2017. Web. 20 Jan 2021.
Vancouver:
Pearce B. Nonthermal plasma synthesis of aluminum nanoparticles. [Internet] [Masters thesis]. University of Minnesota; 2017. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/11299/191241.
Council of Science Editors:
Pearce B. Nonthermal plasma synthesis of aluminum nanoparticles. [Masters Thesis]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/191241
University of St. Andrews
7.
Duque, Ruben.
Supported ionic liquid phase catalysis in continuous supercritical flow
.
Degree: 2013, University of St. Andrews
URL: http://hdl.handle.net/10023/3387
► The separation of the expensive catalysts from the solvent and reaction products remains one of the major disadvantages of homogeneous catalytic reactions, which are otherwise…
(more)
▼ The separation of the expensive catalysts from the solvent and reaction products remains one of the major disadvantages of homogeneous catalytic reactions, which are otherwise advantageous because of their high activity, tuneable selectivity and ease of study.
Ideally, the homogeneous reactions would be carried out in
continuous flow mode with the catalyst remaining in the reactor at all times, whilst the substrates and products
flow over the catalyst.
The system we have been studying is one where the catalyst is dissolved in a thin film of an ionic liquid, and this is supported within the pores of a microporous silica. This supported ionic liquid phase (SILP) catalyst is then placed in a tubular
flow reactor, similar to that used for heterogeneous reactions. The raw materials are then injected into the rig, pass through the reactor and the products and the raw materials that have not reacted are collected at the other end of the rig. Supercritical CO₂ is used to transport the raw materials and products along the catalyst bed, allowing a
continuous flow mode with low leaching for both the catalyst and the ionic liquid.
We have applied this procedure first to alkene metathesis catalysed by a ruthenium complex that has been especially designed to dissolve in 1-butyl-3-methyimidazolium triflamide (BMIM NTf₂), which was used as ionic liquid. Activity is observed for the ring closing metathesis of diethyl 2,2-diallylmalonate, but the catalyst is not stable, only allowing about 300 turnovers. This instability is attributed to the formation of Ru=CH₂ moieties, which dimerise to an inactive species. More success is achieved with internal alkenes such as 2-octene and especially methyl oleate. Self metathesis of methyl oleate continues for >10.000 turnovers over 10 h, with only small decreases in activity. The cross metathesis of methyl oleate with dimethyl maleate has also been studied. Cross metathesis dominates in the early stages of the reaction but the cross metathesis products diminish with time. Surprisingly, the catalyst does not deactivate since self metathesis of methyl oleate continues. The phase behaviour of the reaction was monitored and gave us an insight into the reasons for this change in selectivity.
Methoxycarbonylation reactions in
continuous flow proved to be a much more difficult process than the previous metathesis reactions. Higher catalyst loading was needed to reduce the reaction times. The first
continuous flow reactions showed conversion predominantly, if not exclusive, of 1-octene isomerised products. The presence of ionic liquid (IL) in the SILP system was essential, otherwise the catalyst leached out of the reactor very quickly. Batch reactions showed that none of the studied parameters (absence of presence of either BMIM NTf₂, OMIM NTf₂, silica or CO₂) had any influence on the reaction, but when observing the results it was noticed that the reactions that gave the best results were performed in a close range of pressures between 55 and 70 bar, indicating that the reaction might be pressure…
Advisors/Committee Members: Cole-Hamilton, D. J. (David John) (advisor).
Subjects/Keywords: Ionic liquids;
Supercritical CO₂;
Continuous flow;
Catalysis
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APA ·
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Manager
APA (6th Edition):
Duque, R. (2013). Supported ionic liquid phase catalysis in continuous supercritical flow
. (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/3387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Duque, Ruben. “Supported ionic liquid phase catalysis in continuous supercritical flow
.” 2013. Thesis, University of St. Andrews. Accessed January 20, 2021.
http://hdl.handle.net/10023/3387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Duque, Ruben. “Supported ionic liquid phase catalysis in continuous supercritical flow
.” 2013. Web. 20 Jan 2021.
Vancouver:
Duque R. Supported ionic liquid phase catalysis in continuous supercritical flow
. [Internet] [Thesis]. University of St. Andrews; 2013. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/10023/3387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Duque R. Supported ionic liquid phase catalysis in continuous supercritical flow
. [Thesis]. University of St. Andrews; 2013. Available from: http://hdl.handle.net/10023/3387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Colorado State University
8.
Salvi, Niketa.
Two-step coding theorem in the nearly continuous category.
Degree: PhD, Mathematics, 2013, Colorado State University
URL: http://hdl.handle.net/10217/80173
► In measurable dynamics, one studies the measurable properties of dynamical systems. A recent surge of interest has been to study dynamical systems which have both…
(more)
▼ In measurable dynamics, one studies the measurable properties of dynamical systems. A recent surge of interest has been to study dynamical systems which have both a measurable and a topological structure. A nearly
continuous Z-system consists of a Polish space X with a non-atomic Borel probability measure μ and an ergodic measure-preserving homeomorphism T on X . Let ƒ : X → R be a positive, nearly
continuous function bounded away from 0 and ∞. This gives rise to a
flow built over T under the function ƒ in the nearly
continuous category. Rudolph proved a representation theorem in the 1970's, showing that any measurable
flow, where the function ƒ is only assumed to be measure-preserving on a measurable Z-system, can be represented as a
flow built under a function where the ceiling function takes only two values. We show that Rudolph's theorem holds in the nearly
continuous category.
Advisors/Committee Members: Shipman, Patrick (advisor), Şahin, Ayşe (advisor), Dangelmayr, Gerhard (committee member), Oprea, Iuliana (committee member), Wang, Haonan (committee member).
Subjects/Keywords: flow built under a function; two step flow; nearly continuous
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APA (6th Edition):
Salvi, N. (2013). Two-step coding theorem in the nearly continuous category. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/80173
Chicago Manual of Style (16th Edition):
Salvi, Niketa. “Two-step coding theorem in the nearly continuous category.” 2013. Doctoral Dissertation, Colorado State University. Accessed January 20, 2021.
http://hdl.handle.net/10217/80173.
MLA Handbook (7th Edition):
Salvi, Niketa. “Two-step coding theorem in the nearly continuous category.” 2013. Web. 20 Jan 2021.
Vancouver:
Salvi N. Two-step coding theorem in the nearly continuous category. [Internet] [Doctoral dissertation]. Colorado State University; 2013. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/10217/80173.
Council of Science Editors:
Salvi N. Two-step coding theorem in the nearly continuous category. [Doctoral Dissertation]. Colorado State University; 2013. Available from: http://hdl.handle.net/10217/80173
University of Louisville
9.
Ising, Mickey S.
RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study.
Degree: M. Eng., 2011, University of Louisville
URL: 10.18297/etd/660
;
https://ir.library.louisville.edu/etd/660
► Purpose: Continuous flow (CF) left ventricular assist devices (LVAD) support diminishes vascular pressure pulsatility. Despite its recent clinical success and reliability, CF LVAD support has…
(more)
▼ Purpose:
Continuous flow (CF) left ventricular assist devices (LVAD) support diminishes vascular pressure pulsatility. Despite its recent clinical success and reliability, CF LVAD support has been associated with adverse events including gastrointestinal bleeding, aortic valve insufficiency, and hemorrhagic strokes. To overcome these limitations, we have developed
flow/RPM modulation algorithms to provide vascular pulsatility using a CF LVAD. Methods: The effects of timing and synchronizing the CF LVAD
flow/RPM modulation to the native ventricle, modulation amplitude, and modulation widths were studied on the native ventricle and vasculature using computer simulation, mock loop, and animal model studies. A total of over 100 combinations of
flow modulation algorithms to modulate CF LVAD
flow/RPM were tested for partial and full LVAD support modes. Results: Modulation of CF LVAD
flow/RPM resulted in an increased arterial pressure pulsatility of up to 50 mmHg during asynchronous modulation and 20 mmHg during synchronous modulation. Synchronous CF LVAD RPM modulation allowed for a range of reduced left ventricular external work (LVEW) as compared to un-modulated CF LVAD support conditions. Full support co-pulsation (high RPM during systole, low RPM during diastole) created greater pulse pressures as compared to counter pulsation (high RPM during diastole, low RPM during systole). However, all full support modulation timings yielded higher pulse pressure than normal full support CF LVAD
flow at low ventricular contractilities. Importantly, reduction in LVEW and increase in pulsatility may be adjusted to user-defined values while maintaining the same average CF LVAD
flow rate. Conclusions: These LVAD
flow/RPM modulations may reduce the incidence of adverse events associated with the CF LVAD therapy by increasing vascular pulsatility and reducing vascular impedance. Further, these methods of CF LVAD
flow/RPM modulation may enable tailored unloading of the native ventricle to provide rest and rehabilitation (maximal unloading to rest followed by gradual reloading to wean), which may promote sustainable myocardial recovery.
Advisors/Committee Members: Giridharan, Guruprasad Anapathur.
Subjects/Keywords: Ventricular assist device; Pulsatile flow; Vasculature pulsatility; Cardiovascular modeling; Continuous flow
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APA (6th Edition):
Ising, M. S. (2011). RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/660 ; https://ir.library.louisville.edu/etd/660
Chicago Manual of Style (16th Edition):
Ising, Mickey S. “RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study.” 2011. Masters Thesis, University of Louisville. Accessed January 20, 2021.
10.18297/etd/660 ; https://ir.library.louisville.edu/etd/660.
MLA Handbook (7th Edition):
Ising, Mickey S. “RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study.” 2011. Web. 20 Jan 2021.
Vancouver:
Ising MS. RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study. [Internet] [Masters thesis]. University of Louisville; 2011. [cited 2021 Jan 20].
Available from: 10.18297/etd/660 ; https://ir.library.louisville.edu/etd/660.
Council of Science Editors:
Ising MS. RPM and flow modulation for a continuous flow left ventricular assist device to increase vascular pulsatility : a computer simulation, mock circulation, and in-vivo animal study. [Masters Thesis]. University of Louisville; 2011. Available from: 10.18297/etd/660 ; https://ir.library.louisville.edu/etd/660
NSYSU
10.
Wu, Jia-Lin.
Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips.
Degree: Master, Computer Science and Engineering, 2017, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0023117-100523
► Due to the advances in micro-electromechanical systems (MEMS), the lab-on-a-chip (LOC) has been developed. There are many applications of lab-on-a-chip devices, including point-of-care disease diagnostics,…
(more)
▼ Due to the advances in micro-electromechanical systems (MEMS), the lab-on-a-chip (LOC) has been developed. There are many applications of lab-on-a-chip devices, including point-of-care disease diagnostics, medicine analysis and drugs discovery.
The
flow-based microfluidic biochip is one kind of lab-on-a-chips. On microfluidic biochip platform, digital microfluidic biochip and
flow-based microfluidic biochip are the two major categories of implementation. On digital microfluidic biochip platform, the droplets are manipulated on an array of electrodes. However, there are many microchannels on
flow-based microfluidic biochip and the reactants are manipulated in these closed microchannels. Our proposed microfluidic chip design
flow is on the
flow-based microfluidic biochip platform.
The design procedures of lab-on-a-chip today are by manual owing to lack of computer-aided design tools. Manual design procedures are time consuming and make the developments less efficient. There may be human errors as the designs become complex.
This research proposes a systematic design procedure for the control layer of
flow-based microfluidic biochip. The designers would find the solutions more efficient and prevent human errors through the proposed design procedure. This research mainly considers the skew, matching rate and control pin numbers during the design process. Compared to previous works, our proposed method gets 18.5X improvement in skew, 41% improvement in latency and 49% improvement in matching rate.
Advisors/Committee Members: Tsung-Yi Ho (chair), Wei-Kuang Lai (chair), Shu-Min Li (committee member), Chung-Nan Lee (chair).
Subjects/Keywords: biochip; lab-on-a-chip; continuous flow; routing; microfluidic
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APA (6th Edition):
Wu, J. (2017). Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0023117-100523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wu, Jia-Lin. “Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips.” 2017. Thesis, NSYSU. Accessed January 20, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0023117-100523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wu, Jia-Lin. “Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips.” 2017. Web. 20 Jan 2021.
Vancouver:
Wu J. Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Jan 20].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0023117-100523.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wu J. Simultaneously Optimized Control Pins Placement and Channels Routing of Control-Layer in Flow-Based Microfluidic Biochips. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0023117-100523
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
11.
Ragsdale, Victoria Elizabeth.
Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device.
Degree: MS, Mechanical Engineering, 2012, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/640/rec/2741
► Polymerase Chain Reaction (PCR) is a process which amplifies a specific segment of DNA through a thermal cycling protocol. PCR is largely used in diagnostics,but…
(more)
▼ Polymerase Chain Reaction (PCR) is a process which
amplifies a specific segment of DNA through a thermal cycling
protocol. PCR is largely used in diagnostics,but also has
applications in the defense industry and many others. The PCR
industry is shifting its focus towards micro-scale devices, and
away from macro-scale systems due to i) the micro-scale sample size
requiring less blood from patients, ii) total reaction times on the
order of minutes opposed to hours and iii) the cost advantages as
many microfluidic devices are manufactured from inexpensive
polymers. In general, polymers have many advantages including
minimal microfabrication processes during manufacturing, wide
availability and low cost.This work presents the manufacturing
process as well as simulations and testing results of a disposable
polycarbonate (PC) device capable of achieving PCR in less than 7
minutes by thermally cycling the sample through an established
temperature gradient in aserpentine channel. This device also
features a unique laser manufacturing process eliminating the need
for a microfabrication facility. Two-dimensional (2D) and
three-dimensional (3D) simulations were created to analyze the heat
transfer and fluid dynamics throughout the device. Simulations were
created both in the flow plane, to analyze the reaction
temperatures occurring in each bend of the serpentine channel, and
the out of flow plane, to observe the amount of heat leaving the
system. Although the 2D simulations did not produce the same values
as the 3D models, the same trends wereexhibited so qualitative
observations could still be made. Experiments were performed to
validate the simulations by comparing the measured device surface
temperature from an IR camera to those values from the 3D
simulations. It was found that the device producesfluid temperature
results within the reaction limits for several flow rates with
specific heater temperature settings. An end point PCR melting
analysis was also completed on reactants to determine if PCR was
achieved. These results were unsuccessful, due tohighly
inconsistent flow rates observed during the experiments. Although
PCR was not achieved, with slight changes to increase flow rate
accuracy, PCR is expected to be successful since the IR images
suggest that the fluid is reaching the reaction
temperatures.
Subjects/Keywords: Heat transfer; PCR; Continuous-flow; Polymerase chain reaction device
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APA (6th Edition):
Ragsdale, V. E. (2012). Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/640/rec/2741
Chicago Manual of Style (16th Edition):
Ragsdale, Victoria Elizabeth. “Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device.” 2012. Masters Thesis, University of Utah. Accessed January 20, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/640/rec/2741.
MLA Handbook (7th Edition):
Ragsdale, Victoria Elizabeth. “Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device.” 2012. Web. 20 Jan 2021.
Vancouver:
Ragsdale VE. Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device. [Internet] [Masters thesis]. University of Utah; 2012. [cited 2021 Jan 20].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/640/rec/2741.
Council of Science Editors:
Ragsdale VE. Three-dimensional heat transfer analysis of a disposable,
continuous-flow polymerase chain reaction device. [Masters Thesis]. University of Utah; 2012. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/640/rec/2741
University of Alberta
12.
Corkum, Elizabeth G.
The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions.
Degree: PhD, Department of Chemistry, 2013, University of Alberta
URL: https://era.library.ualberta.ca/files/j67314798
► The development of immobilized asymmetric catalysts is of vital importance as it would allow for easy catalyst recovery from the reaction mixture and reuse. One…
(more)
▼ The development of immobilized asymmetric catalysts is
of vital importance as it would allow for easy catalyst recovery
from the reaction mixture and reuse. One strategy for
immobilization involves the synthesis of insoluble
polymer-supported catalysts. Most polymeric catalysts are made by
polymerizing a chiral ligand, or grafting the ligand to a polymer
support, followed by metallation of the ligand sites. The resulting
catalysts are often plagued by poor activity and reusability due to
incomplete metallation, limited access to catalytic active sites
and metal leaching. The Bergens group developed a method where a
ruthenium metal-containing monomer (MCM) is directly polymerized by
alternating ring-opening metathesis polymerization (altROMP) and
deposited on insoluble barium salts. The resulting catalyst-organic
frameworks (COFs) exhibited remarkable reuse with no drop in
activity or selectivity and no detectable ruthenium leaching. This
dissertation describes the extension of the altROMP methodology to
rhodium-BINAP containing catalysts and their use in the
intramolecular cycloisomerization of 1,6-enynes, solvent-free
allylic alcohol isomerizations and continuous-flow olefin
hydrogenations. The altROMP of MCMs
[RhCl((R)-5,5ʹ-dinorimido-BINAP)]2 (I) and
[Rh(NBD)((R)-5,5ʹ-dinorimido-BINAP)](SbF6) (II), with cyclooctene
as a spacer monomer, and with RuCl2(CHPh)(PCy3)2 as the ROMP
catalyst, gave two novel rhodium-BINAP COFs, Ia and IIa
respectively, that were subsequently deposited on BaSO4 or
Ba-L-tartrate. Framework Ia sustained up to six reuses and provided
the highest TONs to date (up to 890), with no drop in
enantioselectivity (95-99.9% ee), in the cycloisomerization of
1,6-enynes. As well, a key intermediate in the production of
pharmaceutical (+)-pilocarpine was afforded in >99.9% ee.
Framework Ia also provided the highest TONs to date (up to 38,000)
for the rhodium catalyzed isomerization of secondary allylic
alcohols with catalyst loadings as low as 0.0025 mol%. In both
cases, the COF proved to be more active and selective than the
parent homogeneous catalyst. Framework IIa proved to be highly
active in the continuous-flow hydrogenation of a variety of
olefin-containing substrates and sustained up to 55,700 TOs over a
period of 30 days in the H-Cube® continuous-flow reactor. As well,
in a preliminary study, >99.9% ee was obtained in the
continuous-flow hydrogenation of itaconic acid by framework
Ia.
Subjects/Keywords: Catalysis; BINAP; Heterogeneous; Hydrogenation; Isomerization; Rhodium; Continuous-Flow
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APA ·
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Manager
APA (6th Edition):
Corkum, E. G. (2013). The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/j67314798
Chicago Manual of Style (16th Edition):
Corkum, Elizabeth G. “The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions.” 2013. Doctoral Dissertation, University of Alberta. Accessed January 20, 2021.
https://era.library.ualberta.ca/files/j67314798.
MLA Handbook (7th Edition):
Corkum, Elizabeth G. “The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions.” 2013. Web. 20 Jan 2021.
Vancouver:
Corkum EG. The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Jan 20].
Available from: https://era.library.ualberta.ca/files/j67314798.
Council of Science Editors:
Corkum EG. The Synthesis of Rhodium Catalyst-Organic Frameworks for
Isomerization and Continuous-Flow Hydrogenation Reactions. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/j67314798
University of Tasmania
13.
Gstoettenmayr, D.
Development of a continuous flow interface for stacking in capillary electrophoresis.
Degree: 2016, University of Tasmania
URL: https://eprints.utas.edu.au/23050/1/Gstoettenmayr_whole_thesis.pdf
► The main purpose of the present work was to develop and optimize a continuous flow interface to improve the poor concentration detection limits of capillary…
(more)
▼ The main purpose of the present work was to develop and optimize a continuous flow
interface to improve the poor concentration detection limits of capillary electrophoresis
which are one of its main limitations. The question was how the flow rate, applied voltage,
interface and capillary dimensions and conductivities of background electrolyte and sample
solution affect the electrokinetic sample injection in a continuous sample flow interface.
Optimizing these parameters has the potential to perform near quantitative injection from
large sample volumes in a short time. This can lead to the improvement of a variety of
existing techniques that aim at lowering the concentration detection limits of CE.
The injection voltage and flow rate have been optimized and their effect on the injected
sample amount has been investigated using a tee connector in a commercial capillary
electrophoresis instrument. The effect of sample injection from both flowing and static
sample volumes was investigated. Using a tee connector interface with flowing sample
injection, four times more analyte could be injected into the capillary than in a static system.
Theoretical simulations along with experiments were performed to investigate the effect of
flow rate and injection voltage on the injected sample. The results confirmed that more
analyte could be injected into the capillary in a flowing sample interface due to depletion of
the ions from the flowing stream indicating near quantitative injection of all of the ions.
Significant enhancement in the proportion of sample ions that are injected when injecting
from a flowing sample stream has been demonstrated and this work is the only to compare
electrokinetic injection of the same sample volume, under the same conditions with the only
difference being whether the sample stream was flowing or static.
After having established the influence of the flow rate and injection voltage on the injected
sample amount a mathematical model of the continuous sample flow interface was developed. The aim was to investigate the influence of the interface dimensions on the
depletion flow rate, which is the maximum flow rate at a given voltage at which > 90% of all
sample ions are being injected. Besides this the influence of the capillary dimensions and the
conductivity ratio of the sample and backgroundelectrolyte on the depletion flow rate were
investigated. The mathematical model proposed that the total applied voltage, the
electrophoretic sample mobility and the conductivity ratio between the liquid in the interface
and the capillary should be as high as practically possible to give high depletion flow rates.
The conductivity ratio and the electrophoretic sample mobility are determined by the chosen
stacking method and analyte of interest in an experimental setup. High currents pose a
practical limitation to the total voltage that can be applied. The results proposed further that
there is an optimum interface diameter and length at which the depletion flow rate reaches a
…
Subjects/Keywords: continuous flow interface; capillary electrophoresis; stacking; preconcentration; fundamental
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Manager
APA (6th Edition):
Gstoettenmayr, D. (2016). Development of a continuous flow interface for stacking in capillary electrophoresis. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/23050/1/Gstoettenmayr_whole_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gstoettenmayr, D. “Development of a continuous flow interface for stacking in capillary electrophoresis.” 2016. Thesis, University of Tasmania. Accessed January 20, 2021.
https://eprints.utas.edu.au/23050/1/Gstoettenmayr_whole_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gstoettenmayr, D. “Development of a continuous flow interface for stacking in capillary electrophoresis.” 2016. Web. 20 Jan 2021.
Vancouver:
Gstoettenmayr D. Development of a continuous flow interface for stacking in capillary electrophoresis. [Internet] [Thesis]. University of Tasmania; 2016. [cited 2021 Jan 20].
Available from: https://eprints.utas.edu.au/23050/1/Gstoettenmayr_whole_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gstoettenmayr D. Development of a continuous flow interface for stacking in capillary electrophoresis. [Thesis]. University of Tasmania; 2016. Available from: https://eprints.utas.edu.au/23050/1/Gstoettenmayr_whole_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Penn State University
14.
Lanas Medina, Vanessa Alexandra.
Examination of brush anode sizes and packing densities on microbial fuel cell performance.
Degree: 2013, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/18781
► The performance and cost of electrodes are critical to the design of microbial fuel cells (MFCs). Scaling-up MFC technologies for practical purposes requires compact architectures…
(more)
▼ The performance and cost of electrodes are critical to the design of microbial fuel cells (MFCs). Scaling-up MFC technologies for practical purposes requires compact architectures and operation under
continuous flow conditions. In this study, two types of single-chamber air-cathode reactors were used: cubic (28 mL) and rectangular (170 mL) cells. Different carbon-brush anode configurations were evaluated for these two architectures. The anodic configurations differed from each other in Ti wire (current collector) gauge, carbon fiber diameter, number of brushes connected in parallel, and electrode spacing. MFC performance was assessed in terms of power generation, charge, COD removal, coulombic efficiency and internal resistance.
Multi-brush cubic MFCs had power densities, coulombic efficiencies and COD removals similar to single-brush systems, regardless of large differences in total specific surface areas of the brushes. The use of smaller Ti wire diameters did not affect power generation, reducing material use and costs. Electrode loading into the cell (orientation, electrode spacing, projected area anode/cathode) proved to be the most important aspect in overall MFC performance.
The rectangular vertical reactors were operated in both fed-batch and
continuous mode. Electrode spacing between the cathode and the center of mass of the anode, located in the central axis of the brushes, was the most important factor affecting power production. When all multi-anode systems were maintained at the same electrode distance, larger brush diameters (R3) produced as much as twice the power density than smaller ones (R8) in both operational regimes. Additionally, power generation decreased to half when operation was switched from batch to
continuous flow. However, when the multi-anode system with the smallest brush diameters were placed closer to the cathode, having the smallest electrode spacing based on center of mass, this configuration (R8C) produced the largest power densities. These results show that compact MFC designs can provide high performance, being ideal for scale up purposes.
Advisors/Committee Members: Bruce Ernest Logan, Thesis Advisor/Co-Advisor, John Michael Regan, Thesis Advisor/Co-Advisor, William D Burgos, Thesis Advisor/Co-Advisor.
Subjects/Keywords: Microbial fuel cells; biolectrochemistry; anode; continuous flow; renewable energy; wastewater treatment
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APA (6th Edition):
Lanas Medina, V. A. (2013). Examination of brush anode sizes and packing densities on microbial fuel cell performance. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/18781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lanas Medina, Vanessa Alexandra. “Examination of brush anode sizes and packing densities on microbial fuel cell performance.” 2013. Thesis, Penn State University. Accessed January 20, 2021.
https://submit-etda.libraries.psu.edu/catalog/18781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lanas Medina, Vanessa Alexandra. “Examination of brush anode sizes and packing densities on microbial fuel cell performance.” 2013. Web. 20 Jan 2021.
Vancouver:
Lanas Medina VA. Examination of brush anode sizes and packing densities on microbial fuel cell performance. [Internet] [Thesis]. Penn State University; 2013. [cited 2021 Jan 20].
Available from: https://submit-etda.libraries.psu.edu/catalog/18781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lanas Medina VA. Examination of brush anode sizes and packing densities on microbial fuel cell performance. [Thesis]. Penn State University; 2013. Available from: https://submit-etda.libraries.psu.edu/catalog/18781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
15.
Moon, Sooyeon.
Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation.
Degree: 2020, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-27453
► Kohlenhydrate sind die am weitesten verbreiteten Biomoleküle auf der Erde. Diese Moleküle können von einem einzigen Monomer wie Glucose, welche als grundlegende Energiequelle für Pflanzen…
(more)
▼ Kohlenhydrate sind die am weitesten verbreiteten Biomoleküle auf der Erde. Diese Moleküle können von einem einzigen Monomer wie Glucose, welche als grundlegende Energiequelle für Pflanzen und Tiere dient, bis hin zu Hunderten oder Tausenden Monomeren reichen, welche riesige Polymerstrukturen wie Zellulose bilden, die das strukturelle Rückenrad der pflanzlichen Zellwand darstellen. Kohlenhydrate sind neben den Funktionen als Energielieferant und Strukturelement auch in grundlegende biologische Funktionen wie zelluläre Signale, Zellerkennung und Signalwege involviert. Die Gewinnung von Kohlenhydraten aus der Natur ist ein langwieriger, komplizierter biochemischer Prozess und führt sehr oft zu einer Mischung von Verbindungen. Die chemische Synthese von Kohlenhydraten bietet die Möglichkeit, eine definierte chemische Struktur von hoher Reinheit
zu erhalten, was es ermöglicht, die einzelnen biologischen Funktionsbeziehungen zu verstehen und den Bereich der Kohlenhydratforschung weiter zu entwickeln.
Das Kontrollieren der Glykosylierung, der Reaktion die zwei Zuckerbausteine unter Bildung einer glykosidischen Bindung verknüpft, und damit der Stereoselektivität ist eine der Herausforderungen in der modernen organischen Chemie, und basiert auf den bahnbrechenden Erkenntnissen von Emil Fischer im Jahr 1893. Viele Faktoren wie Temperatur, Lösungsmittel, Wassergehalt, Reaktionszeit und Stöchiometrie beeinflussen die Ausbeute der Reaktion und die stereochemische Zusammensetzung des Produkts. Bisher wurden keine umfassenden systematischen Untersuchungen aller dieser Faktoren durchgeführt. Eine große Herausforderung ist die Reproduzierbarkeit der Glykosylierung, die auf die Sensibilität der Reaktion und mangelnde Kontrolle über die Reaktionsbedingungen durch den Experimentator zurückzuführen ist. Durchflusschemie und Automatisierung bieten hier erhebliche Möglichkeiten die Kontrolle und damit die Reproduzierbarkeit chemischer Reaktionen zu optimieren.
Daher wurde in dieser Dissertation eine vollautomatische durchflusschemische Plattform für die umfassende Untersuchung von Glykosylierungsreaktionen entwickelt, in der systematisch die Reaktionsbedingungen variiert und deren Einfluss auf Ausbeute und stereochemischen Zusammensetzung des Produkts untersucht werden können. In dieser sechs Kapitel umfassenden Arbeit werden die Herausforderungen beim Verständnis des Glykosylierungsmechanismus vorgestellt, und die zur Bewältigung verwendeten Werkzeuge beschrieben. Dazu gehören die automatisierte durchflusschemische Plattform zur Untersuchung der chemischen Glykosylierung und die Entwicklung eines zufälligen „Random Forest“ basierten Modells für maschinelles Lernen, das der Vorhersage der stereochemischen Zusammensetzung des Produkts dient.
Kapitel 1 erörtert die Herausforderungen beim Verständnis des Glykosylierungs-mechanismus, und die verschiedenen Faktoren, die das Ergebnis der Glykosylierung beeinflussen, um damit im durchflusschemischen Ansatz eine größere Kontrolle über die Reaktion erhalten zu können. Kapitel 2 stellt…
Advisors/Committee Members: female (gender), Seeberger, Peter (firstReferee), Pagel, Kevin (furtherReferee).
Subjects/Keywords: Chemical Glycosylation; Automation; Machine Learning; Carbohydrate; Continuous Flow; Microreactor; ddc:547
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APA (6th Edition):
Moon, S. (2020). Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27453
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moon, Sooyeon. “Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation.” 2020. Thesis, Freie Universität Berlin. Accessed January 20, 2021.
http://dx.doi.org/10.17169/refubium-27453.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moon, Sooyeon. “Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation.” 2020. Web. 20 Jan 2021.
Vancouver:
Moon S. Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Jan 20].
Available from: http://dx.doi.org/10.17169/refubium-27453.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moon S. Using Automation, Theory and Machine Learning to Gain Mechanistic Understanding of Chemical Glycosylation. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27453
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
16.
Corbin, Joel Christopher.
Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei.
Degree: 2011, University of Toronto
URL: http://hdl.handle.net/1807/27332
► Ice crystals in clouds frequently form upon a subset of aerosol particles called ice nuclei (IN). IN influence cloud ice crystal concentrations, consequently affecting cloud…
(more)
▼ Ice crystals in clouds frequently form upon a subset of aerosol particles called ice nuclei (IN). IN influence cloud ice crystal concentrations, consequently affecting cloud lifetime and reflectivity. The present understanding of these effects on climate is hindered by limited data on the global distribution of IN.
This thesis presents measurements of deposition-mode IN concentrations under conditions relevant to mid-level clouds, 238 K and 138% RHi. at two Canadian sites: Toronto, a major city, and Whistler, a pristine coniferous rainforest.
In Toronto, chemically-resolved surface areas were estimated by single-particle mass spectrometry and regressed against IN concentrations to identify a significant relationship between IN concentrations and both carbonaceous aerosols (EC and/or OC) and dust. In Whistler, IN concentrations during a biogenic secondary organic aerosol (SOA) event did not increase from background levels (0.1 /L), suggesting that biogenic SOA particles do not nucleate ice under these conditions.
MAST
Advisors/Committee Members: Abbatt, Jonathan P. D., Evans, Greg J., Chemical Engineering and Applied Chemistry.
Subjects/Keywords: Ice nucleation; Continuous Flow Diffusion Chamber; IN; Toronto; Whistler; ATOFMS; 0542
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APA (6th Edition):
Corbin, J. C. (2011). Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/27332
Chicago Manual of Style (16th Edition):
Corbin, Joel Christopher. “Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei.” 2011. Masters Thesis, University of Toronto. Accessed January 20, 2021.
http://hdl.handle.net/1807/27332.
MLA Handbook (7th Edition):
Corbin, Joel Christopher. “Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei.” 2011. Web. 20 Jan 2021.
Vancouver:
Corbin JC. Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/1807/27332.
Council of Science Editors:
Corbin JC. Development and Deployment of a Continuous-flow Diffusion Chamber for the Field Measurement of Atmospheric Ice Nuclei. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/27332
University of Bath
17.
Al Badran, Firas.
Reactor design : compact and catalytic for speciality chemicals.
Degree: PhD, 2011, University of Bath
URL: https://researchportal.bath.ac.uk/en/studentthesis/reactor-design-compact-and-catalytic-for-speciality-chemicals(e6dbdcc1-e46a-48ff-9ddc-aa10991c7c56).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545331
► When speciality chemicals are manufactured within the pharmaceutical industry, they are often produced in stirred batch/semi-batch reactors. A ‘methodology’ was explored, to help with the…
(more)
▼ When speciality chemicals are manufactured within the pharmaceutical industry, they are often produced in stirred batch/semi-batch reactors. A ‘methodology’ was explored, to help with the development of continuous fixed-bed catalytic reactors for this sector. This was tested on two different types of model reactions: (a) In the first, the viability of producing tertiary amines via ‘borrowing hydrogen’ was explored, and the reaction of morpholine and benzyl alcohol was studied, on Ru and Pt catalysts. This provided an opportunity for an early involvement in small-scale batch testing of catalysts, and then experiments were performed with the catalyst supported on granules in a packed bed (i.d. = 7 mm, length = 300 mm). Although it was shown that continuous processing is viable, and that high conversions (e.g. 73 to 98%, at 150 ºC) could be achieved, unfortunately further work was necessary to identify a more robust catalyst system, before moving on to pilot-scale trials. (b) In the second, the partial oxidation of benzyl alcohol to benzaldehyde was studied, using a Pt catalyst on a carbon support. This proved to be successful, and the reaction was finally demonstrated at pilot-scale. Carbon monoliths were used as catalyst supports (monolith o.d. = 19 mm; length = 50 mm long; square 0.7 mm x 0.7 mm channels; catalyst loading 2.5 and 2.7 wt% Pt). With a liquid flow of 1 L h-1 and a reactant concentration of ~1 mol L-1, operating at 110 ºC, conversion ranged from 80 to 90% and selectivity from 65 to 99%. The catalyst system was tested for 160 h of operation, and retained its performance. While testing the 2nd reaction, a pilot-scale reactor was also developed, which could be used for a variety of novel reactions. The design was flexible and it was easy to insert and remove the catalytic monoliths.
Subjects/Keywords: 660.2832; Continuous flow reactor; pharmaceutical industry; N-Alkylation; oxidation
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Manager
APA (6th Edition):
Al Badran, F. (2011). Reactor design : compact and catalytic for speciality chemicals. (Doctoral Dissertation). University of Bath. Retrieved from https://researchportal.bath.ac.uk/en/studentthesis/reactor-design-compact-and-catalytic-for-speciality-chemicals(e6dbdcc1-e46a-48ff-9ddc-aa10991c7c56).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545331
Chicago Manual of Style (16th Edition):
Al Badran, Firas. “Reactor design : compact and catalytic for speciality chemicals.” 2011. Doctoral Dissertation, University of Bath. Accessed January 20, 2021.
https://researchportal.bath.ac.uk/en/studentthesis/reactor-design-compact-and-catalytic-for-speciality-chemicals(e6dbdcc1-e46a-48ff-9ddc-aa10991c7c56).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545331.
MLA Handbook (7th Edition):
Al Badran, Firas. “Reactor design : compact and catalytic for speciality chemicals.” 2011. Web. 20 Jan 2021.
Vancouver:
Al Badran F. Reactor design : compact and catalytic for speciality chemicals. [Internet] [Doctoral dissertation]. University of Bath; 2011. [cited 2021 Jan 20].
Available from: https://researchportal.bath.ac.uk/en/studentthesis/reactor-design-compact-and-catalytic-for-speciality-chemicals(e6dbdcc1-e46a-48ff-9ddc-aa10991c7c56).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545331.
Council of Science Editors:
Al Badran F. Reactor design : compact and catalytic for speciality chemicals. [Doctoral Dissertation]. University of Bath; 2011. Available from: https://researchportal.bath.ac.uk/en/studentthesis/reactor-design-compact-and-catalytic-for-speciality-chemicals(e6dbdcc1-e46a-48ff-9ddc-aa10991c7c56).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545331
18.
Miao, Wenfeng.
Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult.
Degree: Design and Engineering, 2011, Mälardalen University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12878
► The objective of this project is to improve productivity and efficiency for the inbound material handling operations in the warehouse of DC Älmhult. After…
(more)
▼ The objective of this project is to improve productivity and efficiency for the inbound material handling operations in the warehouse of DC Älmhult. After three weeks pre-study in place of the distribution center, the authors have observed several problems existing in the current production, among which three types of wastes are found and analyzed by using VSM that are pick and drop, operator waiting time and inefficient transport.
Two typical cases chosen from the inbound production are analyzed to reflect the current process and address problems. Fish-bone tool is used to identify wastes and roots.
To eliminate or reduce the wastes, recommendations and solutions are developed by creating continuous flow combining with internal transport optimization. Future-state VSMs are drawn based on the suggested changes in line with continuous flow.
Different productions models are simulated by elaborately developed excel sheets. A „distance table‟ is developed by using Microsoft Excel to help the loading or unloading leaders with the gate steering function so as to minimize internal transport distance. A new layout of the conveyor system is also suggested to lower the idle transport rate.
Subjects/Keywords: IKEA DC Älmhult; Warehouse; VSM; Waste; Continuous Flow; Internal Transport
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APA (6th Edition):
Miao, W. (2011). Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult. (Thesis). Mälardalen University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12878
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Miao, Wenfeng. “Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult.” 2011. Thesis, Mälardalen University. Accessed January 20, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12878.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Miao, Wenfeng. “Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult.” 2011. Web. 20 Jan 2021.
Vancouver:
Miao W. Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult. [Internet] [Thesis]. Mälardalen University; 2011. [cited 2021 Jan 20].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12878.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Miao W. Creating Continuous Flow and Internal Transport Optimization at IKEA Distribution Center, Älmhult. [Thesis]. Mälardalen University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12878
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Delft University of Technology
19.
Roy, Mrinal (author).
Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water.
Degree: 2019, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:5f6fc199-1141-4f84-991c-e6ea4ec53d81
► Human exposure to the toxic element arsenic due to consumption of arsenic contaminated water is still a global issue worldwide. Conventional treatment techniques are not…
(more)
▼ Human exposure to the toxic element arsenic due to consumption of arsenic contaminated water is still a global issue worldwide. Conventional treatment techniques are not very efficient at removing arsenite, which is the predominant species of arsenic in raw groundwater. Biological oxidation of arsenite by arsenic oxidizing bacteria (AsOB) has shown potential to effectively oxidize arsenite to arsenate without use of any chemicals. Arsenite is then effectively removed by adsorption or separation technologies. Iron Electrocoagulation (Fe-EC) is also emerging as an influential technique for arsenic removal that involves in-situ generation of iron coagulants using iron electrodes by electrolytic oxidation of anode. The main advantage of Fe-EC is that it does not require dosage of chemical coagulants so can be beneficial to communities with better access to electricity than chemicals. This research work is done to combine the two techniques: biological oxidation of arsenite and Fe-EC, for better removal of arsenite from water. Batch studies on Fe-EC were performed in the laboratory to investigate the effects of charge dosage, charge dosage rate, initial arsenic concentration, arsenic oxidation state and different water matrices on the rate and extent of arsenic removal. Also, growth of AsOB on suitable bio-carrier was performed by continuous dosing of 150 μg/L arsenite-spiked water over a period of 49 days. The AsOB grown on the bio-carriers performed 90 % oxidation of 150 μg/L arsenite after a period of 35 days. Finally, two continuous flow system were developed one containing arsenite oxidation step by AsOB followed by Fe-EC and rapid sand filtration whereas the other contained only Fe-EC and rapid sand filtration. The system containing biological oxidation followed by Fe- EC removed arsenite below the WHO standard (10 μg/L ) from an initial arsenite concentration of 150 μg/L at a low iron dosage compared to the system where only Fe-EC was applied.
Environmental Biotechnology
Advisors/Committee Members: Rietveld, Luuk (mentor), van Halem, Doris (mentor), Spanjers, H. (mentor), van Genuchten, Case (mentor), Delft University of Technology (degree granting institution).
Subjects/Keywords: Arsenite Removal; Iron Electrocoagulation; Biological Oxidation; Continuous Flow System
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APA (6th Edition):
Roy, M. (. (2019). Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:5f6fc199-1141-4f84-991c-e6ea4ec53d81
Chicago Manual of Style (16th Edition):
Roy, Mrinal (author). “Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water.” 2019. Masters Thesis, Delft University of Technology. Accessed January 20, 2021.
http://resolver.tudelft.nl/uuid:5f6fc199-1141-4f84-991c-e6ea4ec53d81.
MLA Handbook (7th Edition):
Roy, Mrinal (author). “Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water.” 2019. Web. 20 Jan 2021.
Vancouver:
Roy M(. Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Jan 20].
Available from: http://resolver.tudelft.nl/uuid:5f6fc199-1141-4f84-991c-e6ea4ec53d81.
Council of Science Editors:
Roy M(. Integrating Biological Oxidation of Arsenite with Iron Electrocoagulation: A Novel In-line Technique for Enhanced Removal of Arsenite from Water. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:5f6fc199-1141-4f84-991c-e6ea4ec53d81
University of Melbourne
20.
Johnson, Brian A.
Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches.
Degree: 2011, University of Melbourne
URL: http://hdl.handle.net/11343/36699
► The histrionicotoxins are a family of alkaloids, originally isolated from the skin extracts of the amphibian Dendrobatidae histrionicus, that display non-competitive inhibition of the nicotinic…
(more)
▼ The histrionicotoxins are a family of alkaloids, originally isolated from the skin extracts of the amphibian Dendrobatidae histrionicus, that display non-competitive inhibition of the nicotinic acetylcholine receptor. The biological activity of these compounds, combined with a protected natural source, has given rise to considerable interest from a synthetic chemistry standpoint.
This manuscript describes the synthesis of 6,6,5-isoxazolidine scaffolds of the histrionicotoxin spirocycles, from bis-α,β-unsaturated nitrile intermediates of well defined stereochemistry, using both conventional batch-type and continuous flow techniques.
A library of both racemic and enantiomeric examples of perhydrohistrionicotoxin and its conformationally restricted precursors has been synthesised. Additionally, analogues of perhydrohistrionicotoxin, one example bearing an epimeric centre and other species furnished with pendant side chains of increased length have been synthesised.
Subjects/Keywords: alkaloids; histrionicotoxin; analogues; continuous flow; synthesis; nitrone dipolar cycloadditions
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APA (6th Edition):
Johnson, B. A. (2011). Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/36699
Chicago Manual of Style (16th Edition):
Johnson, Brian A. “Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches.” 2011. Doctoral Dissertation, University of Melbourne. Accessed January 20, 2021.
http://hdl.handle.net/11343/36699.
MLA Handbook (7th Edition):
Johnson, Brian A. “Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches.” 2011. Web. 20 Jan 2021.
Vancouver:
Johnson BA. Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches. [Internet] [Doctoral dissertation]. University of Melbourne; 2011. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/11343/36699.
Council of Science Editors:
Johnson BA. Synthesis of histrionicotoxin analogues using coventional and continuous flow approaches. [Doctoral Dissertation]. University of Melbourne; 2011. Available from: http://hdl.handle.net/11343/36699
21.
Vicens, Jim.
Continuous Zeolite Crystallization in Micro-Batch Segmented Flow.
Degree: MS, 2018, Worcester Polytechnic Institute
URL: etd-042518-160129
;
https://digitalcommons.wpi.edu/etd-theses/1307
► Zeolites are porous aluminosilicates that occur both naturally and synthetically, having numerous applications in catalysis, adsorption and separations. Despite over a half century of characterization…
(more)
▼ Zeolites are porous aluminosilicates that occur both naturally and synthetically, having numerous applications in catalysis, adsorption and separations. Despite over a half century of characterization and synthetic optimization of hundreds of frameworks, the exact mechanism of synthesis remains highly contested, with crystallization typically occurring under transport-limited regimes. In this work, a microcrystallization reactor working under segmented oscillatory
flow has been designed to produce a semi-
continuous flow of zeolite A. The fast injection of the reactants in a mixing section forms droplets of aqueous precursors in a stream of paraffin, dispersing microdroplets and avoiding any clog from occurring in the system. The crystallization occurred in the system at atmospheric pressure and isothermal conditions (65ºC). This allowed for a rather slow crystallization kinetics which was important to study and highlight the different crystallization mechanisms between
flow and batch synthesis. The morphology, size distributions, crystallinity, and porosity were examined by ex-situ characterization of the samples by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, and N2 Physisorption to support the conclusions drawn. The size distribution of the particles achieved in the
flow reactor was conclusively narrower than the distribution achieved in the batch reactor. The average size of the crystals for both synthesis methods is reported as 400 nm and the crystallinity achieved was comparable between the two. However, the morphology was quite different between the two systems, the
flow products having a much higher mesoporosity due to the presence of crystal aggregates at high crystallinity when compared to the batch crystals. Finally, extended crystallization times leads to a decline of the crystallinity of the product, which might be explained by the metastable state of zeolites in solution.
Advisors/Committee Members: Andrew R. Teixeira, Advisor, Michael T. Timko, Committee Member, John A. Bergendahl, Committee Member.
Subjects/Keywords: continuous synthesis; flow crystallization; Heterogeneous catalysis; LTA NaA; microfluidic; zeolites
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APA (6th Edition):
Vicens, J. (2018). Continuous Zeolite Crystallization in Micro-Batch Segmented Flow. (Thesis). Worcester Polytechnic Institute. Retrieved from etd-042518-160129 ; https://digitalcommons.wpi.edu/etd-theses/1307
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vicens, Jim. “Continuous Zeolite Crystallization in Micro-Batch Segmented Flow.” 2018. Thesis, Worcester Polytechnic Institute. Accessed January 20, 2021.
etd-042518-160129 ; https://digitalcommons.wpi.edu/etd-theses/1307.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vicens, Jim. “Continuous Zeolite Crystallization in Micro-Batch Segmented Flow.” 2018. Web. 20 Jan 2021.
Vancouver:
Vicens J. Continuous Zeolite Crystallization in Micro-Batch Segmented Flow. [Internet] [Thesis]. Worcester Polytechnic Institute; 2018. [cited 2021 Jan 20].
Available from: etd-042518-160129 ; https://digitalcommons.wpi.edu/etd-theses/1307.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vicens J. Continuous Zeolite Crystallization in Micro-Batch Segmented Flow. [Thesis]. Worcester Polytechnic Institute; 2018. Available from: etd-042518-160129 ; https://digitalcommons.wpi.edu/etd-theses/1307
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
22.
Woodham, Wesley H.
Introducing Sustainability into Industrial Homogeneous Catalysis.
Degree: PhD, Chemical and Biomolecular Engineering, 2015, Georgia Tech
URL: http://hdl.handle.net/1853/56216
► This thesis describes four projects focused on the implementation of green chemistry and engineering in an industrial context. The first project describes efforts to transition…
(more)
▼ This thesis describes four projects focused on the implementation of green chemistry and engineering in an industrial context. The first project describes efforts to transition Meerwein-Ponndorf-Verley reduction technology from a batch-wise production framework to a
continuous-
flow framework. This work was done in the context of improving the synthesis of HIV-protease inhibitor intermediates. The second project describes a similar transfer of hydropyridoindole synthesis technology from batch processing to
continuous-
flow processing. In particular, a tandem synthetic pathway was developed for conducting cyclopropanation and ring-opening cyclization reactions in series. The third project describes the development of a novel catalyst separation process incorporating the use of sulfur-containing additives and Organic-Aqueous Tunable Solvents. Specifically, this process is demonstrated on palladium catalysts that have been employed in Suzuki coupling reaction mixtures. The fourth project describes the development of a recyclable catalytic system for use in Suzuki coupling reaction processes. The technology described incorporates the use of water-soluble ligands to generate hydrophilic palladium species that can be recovered via Organic-Aqueous Tunable Solvents and reintroduced as an active catalyst species.
Advisors/Committee Members: Liotta, Charles (advisor), Meredith, Carson (committee member), Sievers, Carsten (committee member), Walton, Krista (committee member), Fisk, Jason (committee member).
Subjects/Keywords: Homogeneous catalysis; continuous-flow; smart solvents; tunable solvents
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Manager
APA (6th Edition):
Woodham, W. H. (2015). Introducing Sustainability into Industrial Homogeneous Catalysis. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/56216
Chicago Manual of Style (16th Edition):
Woodham, Wesley H. “Introducing Sustainability into Industrial Homogeneous Catalysis.” 2015. Doctoral Dissertation, Georgia Tech. Accessed January 20, 2021.
http://hdl.handle.net/1853/56216.
MLA Handbook (7th Edition):
Woodham, Wesley H. “Introducing Sustainability into Industrial Homogeneous Catalysis.” 2015. Web. 20 Jan 2021.
Vancouver:
Woodham WH. Introducing Sustainability into Industrial Homogeneous Catalysis. [Internet] [Doctoral dissertation]. Georgia Tech; 2015. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/1853/56216.
Council of Science Editors:
Woodham WH. Introducing Sustainability into Industrial Homogeneous Catalysis. [Doctoral Dissertation]. Georgia Tech; 2015. Available from: http://hdl.handle.net/1853/56216
University of Louisville
23.
Baumann, Daniel.
Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media.
Degree: M. Eng., 2012, University of Louisville
URL: 10.18297/etd/84
;
https://ir.library.louisville.edu/etd/84
► Wounds care and management is one of the most basic needs in the medical setting. Burn wounds, trauma wounds, pressure ulcers and bedsores are…
(more)
▼ Wounds care and management is one of the most basic needs in the medical setting. Burn wounds, trauma wounds, pressure ulcers and bedsores are just some of the many types of wounds that need to be treated quickly and efficiently. Take for instance pressure ulcers, there at least 3 million reported cases of chronic ulcers and bedsores reported in the U.S. each year alone. Each ulcer can takes weeks to months to fully heal, leading to extended hospital stays and decreased quality of life in patients. Current treatment seeks to protect and keep the wound clean, manage cellular exudates, and in general reduce wound area. This is done by packing antibiotic gels into the wound bed, which have a bolus drug release profile, and covering the area with commercially available bandages. There are many studies documenting bolus drug release profiles and their effects on wounds, but what is distinctly absent are studies which investigate the effects of
continuous drug delivery on wound healing. Here it is hypothesized that applying a
continuous flow of fresh drugs into the wound bed will speed up the often lengthy wound healing process. To examine this hypothesis, human umbilical vein endothelial cells (HUVEC) and adult human dermal fibroblasts (HDFa) cell culture models were used to mimic the wound healing process. Results were characterized by the rate of cell migration and proliferation (wound closure) into a simulated wound channel created in the middle of nearly confluent HUVEC and HDFa cell culture models. Both cell types were exposed to static or
continuous flow conditions with and without drug infused media. For the HUVEC cells testing indicates a significant difference between the average rate of closure for
flow versus no
flow conditions (0.0628 versus 0.0232 percent closure per minute, p = 0.00165). For the HDFa cells testing indicates a significant difference between the average rate of closure for
flow versus no
flow conditions (0.0595 versus 0.0392 percent closure per minute, p = 0.01606). The research suggests that positive growth rate occurs in HDF and HUVEC when
continuous low
flow conditions are applied to the cells.
Advisors/Committee Members: Ehringer, William D..
Subjects/Keywords: Flow effects; HUVEC; Continuous perfusion; HDFa; Wound closure
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APA (6th Edition):
Baumann, D. (2012). Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/84 ; https://ir.library.louisville.edu/etd/84
Chicago Manual of Style (16th Edition):
Baumann, Daniel. “Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media.” 2012. Masters Thesis, University of Louisville. Accessed January 20, 2021.
10.18297/etd/84 ; https://ir.library.louisville.edu/etd/84.
MLA Handbook (7th Edition):
Baumann, Daniel. “Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media.” 2012. Web. 20 Jan 2021.
Vancouver:
Baumann D. Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media. [Internet] [Masters thesis]. University of Louisville; 2012. [cited 2021 Jan 20].
Available from: 10.18297/etd/84 ; https://ir.library.louisville.edu/etd/84.
Council of Science Editors:
Baumann D. Effect of flow on human endothelial cell and dermal cell growth rates supplemented with drug infused media. [Masters Thesis]. University of Louisville; 2012. Available from: 10.18297/etd/84 ; https://ir.library.louisville.edu/etd/84
Colorado School of Mines
24.
Lesak, Mark C.
Odometry for autonomous navigation in GPS denied environments.
Degree: MS(M.S.), Mechanical Engineering, 2019, Colorado School of Mines
URL: http://hdl.handle.net/11124/173044
► The mining industry is dangerous and puts human lives at risk daily, including hazardous environments such as: poor air quality due to gas leaks and…
(more)
▼ The mining industry is dangerous and puts human lives at risk daily, including hazardous environments such as: poor air quality due to gas leaks and dust, unstable structural mine adits after controlled detonations or natural disasters, and possible entrapment. Robots that can safely navigate into underground mining environments can conduct reconnaissance to inspect these hazardous environments reducing the risk to human lives. This thesis presents methods to enable autonomous navigation in underground mines, to include: 1) the system design for a flying platform, 2) computer vision techniques to extract the real-time pose of a moving robot, and 3) a Map Free LiDAR Odometry (MFLO) method. The flying platform system design focused on autonomously navigating in an underground mine. The complete system incorporates multiple sensors, an on-board embedded system, electrical connections, cabling, and an on-board power management system. Software was developed that integrates the sensors and fuses the measurements to be utilized for real-time odometry, obstacle avoidance, and control updates. A health monitor node was expanded to further ensure the safety of the aircraft. Computer vision strategies were developed to calculate the real-time pose of a moving robot with respect to a known static robot's position. The methods are: 1) ArUco Marker Identification, and 2) LED marker identification. Results are captured for both ArCuo and LED marker identification methods. Lastly, a real-time method to extract 3D ego-motion using a range
flow constraint equation was developed. The method is map free, computationally light-weight, and reliable. MFLO is designed to operate in GPS-denied and light-deficient environments, making it ideal for small autonomous systems operating in underground mines. The range
flow approach presented here performs up to 0.46% position accuracy for an underground mine environment with a computation time of 20 – 96\,ms, depending on sensor resolution.
Advisors/Committee Members: Petruska, Andrew J. (advisor), Zhang, Hao (committee member), Zhang, Xiaoli (committee member).
Subjects/Keywords: ego-motion estimation; odometry; robotics; LiDAR; continuous-time; Range Flow
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APA (6th Edition):
Lesak, M. C. (2019). Odometry for autonomous navigation in GPS denied environments. (Masters Thesis). Colorado School of Mines. Retrieved from http://hdl.handle.net/11124/173044
Chicago Manual of Style (16th Edition):
Lesak, Mark C. “Odometry for autonomous navigation in GPS denied environments.” 2019. Masters Thesis, Colorado School of Mines. Accessed January 20, 2021.
http://hdl.handle.net/11124/173044.
MLA Handbook (7th Edition):
Lesak, Mark C. “Odometry for autonomous navigation in GPS denied environments.” 2019. Web. 20 Jan 2021.
Vancouver:
Lesak MC. Odometry for autonomous navigation in GPS denied environments. [Internet] [Masters thesis]. Colorado School of Mines; 2019. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/11124/173044.
Council of Science Editors:
Lesak MC. Odometry for autonomous navigation in GPS denied environments. [Masters Thesis]. Colorado School of Mines; 2019. Available from: http://hdl.handle.net/11124/173044
Johannes Gutenberg Universität Mainz
25.
Oberbillig, Thomas.
Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen.
Degree: 2012, Johannes Gutenberg Universität Mainz
URL: http://ubm.opus.hbz-nrw.de/volltexte/2013/3414/
► Zur Entwicklung einer selektiven Tumorimmuntherapie wurden im Rahmen dieser Dissertation potentielle Vakzine dargestellt. Als Leitstruktur für die Impfstoffkandidaten diente das Oberflächenglycoprotein MUC1, das durch fehlregulierte…
(more)
▼ Zur Entwicklung einer selektiven Tumorimmuntherapie wurden im Rahmen dieser Dissertation potentielle Vakzine dargestellt. Als Leitstruktur für die Impfstoffkandidaten diente das Oberflächenglycoprotein MUC1, das durch fehlregulierte Enzymaktivitäten auf malignen Zellen strukturell verändert überexprimiert wird. Hierbei wurde insbesondere der Einfluss von Fluorsubstituenten in der Glycanseitenkette auf die Immunogenität und die Spezifität der Vakzine untersucht. Dazu wurde ein dreifach fluoriertes Analogon an Tetanus Toxoid (TTox) als Trägerprotein angebunden und in Immunisierungsstudien an transgenen Mäusen konnten hohe Selektivitäten und starke Immunantworten nachgewiesen werden. Die Darstellung des 20 Aminosäuren umfassenden Glycopeptides erfolgte an der festen Phase, wobei unterschiedlich fluorierte Thomsen-Friedenreich-Antigenanaloga anstelle eines Threonins in die Sequenz eingebaut wurden. Diese Bausteine wurden durch Glycosylierungsreaktionen fluorierter Donoren sowie Akzeptoren hergestellt, wobei Letztere durch nachträgliche Fluorierungen der Glycosylaminosäure erhalten wurden. Darüber hinaus wurde die Durchführung der komplexen Glycosylierungsreaktionen in Mikroreaktoren am Beispiel zweier fluorierter Glycosylaminosäuren untersucht. Neben der raschen Optimierung der Reaktionsparameter in Durchflussreaktoren konnte die direkte Umsetzung in einem mikrostrukturierten Reaktor in den präparativen Maßstab demonstriert werden.
In the present thesis the preparation of potential vaccines for the development of a tumor-immune therapy is described whereas the MUC1-glycoproteine has been used as leading structure. On malignant cells this glycopeptide is overexpressed and due to incorrect enzyme activities its structure differs from healthy cells. In detail, the influence of fluorine as substituent in the carbohydrate side chains on selectivity an immunogenicity of such a vaccine candidate has been investigated. The use of a conjugate of a threefold fluorinated MUC1-analogue and tetanus toxoid (TTox) as carrier protein in immunization studies on transgenic mice lead to strong immune responses and simultaneously to high selectivity. The syntheses of the 20 amino acids comprising glycopeptides were carried out in a solid phase reactor whereas variably fluorinated Thomsen-Friedenreich antigen analogues were installed in the sequence instead of a threonine. These building blocks have been synthesized by glycosylation reactions of different fluorinated glycosyl donors and acceptors. Regarding the preparation of the latter the fluorination was done after the glycosyl amino acids have been synthesized. In addition the application of microreactors as a tool for the complex glycosylation reactions was investigated for two different fluorinated glycosyl amino acids. The possibility of a fast optimization of reaction parameters as well as the easy transfer into a preparative process have been demonstrated.
Subjects/Keywords: Glycopeptide; Mikroreaktor; fluorierte Kohlenhydrate; Continuous Flow; Vakzin; Tumorimmuntherapie; glycopetides; microreactor; fluorinated carbohydrates; continuous flow; vaccine; tumour immuno therapy; Chemistry and allied sciences
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APA (6th Edition):
Oberbillig, T. (2012). Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen. (Doctoral Dissertation). Johannes Gutenberg Universität Mainz. Retrieved from http://ubm.opus.hbz-nrw.de/volltexte/2013/3414/
Chicago Manual of Style (16th Edition):
Oberbillig, Thomas. “Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen.” 2012. Doctoral Dissertation, Johannes Gutenberg Universität Mainz. Accessed January 20, 2021.
http://ubm.opus.hbz-nrw.de/volltexte/2013/3414/.
MLA Handbook (7th Edition):
Oberbillig, Thomas. “Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen.” 2012. Web. 20 Jan 2021.
Vancouver:
Oberbillig T. Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen. [Internet] [Doctoral dissertation]. Johannes Gutenberg Universität Mainz; 2012. [cited 2021 Jan 20].
Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3414/.
Council of Science Editors:
Oberbillig T. Synthese mehrfach fluorierter MUC1-Glycopeptide für die Entwicklung tumorselektiver Vakzine und Untersuchung Mikroreaktor-unterstützter Bausteinsynthesen. [Doctoral Dissertation]. Johannes Gutenberg Universität Mainz; 2012. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3414/
26.
Barestrand, Henrik.
Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters.
Degree: Engineering Sciences and Mathematics, 2016, Luleå University of Technology
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-59847
► The current demands on Swedish steel industry to produce low quantity batches of specialized products requires research on steel casting processes. There are several…
(more)
▼ The current demands on Swedish steel industry to produce low quantity batches of specialized products requires research on steel casting processes. There are several physical processes that need be taken into account for this problem to be viewed in full light such as thermal-processes, solidification and fluid dynamics. This work focuses on the fluid-dynamics part; more specifically, the dependence of flow quality within the caster on nozzle and mould geometry. The simulations are carried out using a scale-resolving method, in specific LES (Large Eddy Simulation) which is coupled with a DPM (Discrete Phase Model) to model Argon behaviour. The results of these simulations are presented and validated against physical experiment and data from industrial trials. Conclusions are drawn regarding optimal nozzle types in respect to different mould geometries. The mould eigenfrequencies are shown to exhibit a connection with the casting velocity. This results in so called sweet spots in casting velocity where flow irregularities due to sloshing is minimal. It is shown that the mountain type nozzle is preferable for smaller geometries whilst comparatively larger geometries benefit from a cup type.
FLOWFLEX CC
Subjects/Keywords: numerical modelling; physical modelling; fluid flow; continuous casting; casting; mould flow; fluid dynamics; flexible operation of continuous casters; LES; DPM; large eddy simulation; Computational Mathematics; Beräkningsmatematik; Physical Sciences; Fysik
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APA (6th Edition):
Barestrand, H. (2016). Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters. (Thesis). Luleå University of Technology. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-59847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Barestrand, Henrik. “Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters.” 2016. Thesis, Luleå University of Technology. Accessed January 20, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-59847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Barestrand, Henrik. “Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters.” 2016. Web. 20 Jan 2021.
Vancouver:
Barestrand H. Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters. [Internet] [Thesis]. Luleå University of Technology; 2016. [cited 2021 Jan 20].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-59847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Barestrand H. Numerical & physical modelling of fluid flow in a continuous casting mould : Flow dynamics studies for flexible operation of continuous casters. [Thesis]. Luleå University of Technology; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-59847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Priscila Lane Lemos Teixeira.
GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
.
Degree: Master, 2012, Universidade Federal do Ceará
URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8937
;
► Como o processo de gaseificaÃÃo do glicerol adquire um balanÃo energÃtico desfavorÃvel, Ã sugerida a operaÃÃo de um gaseificador como dispositivo de heat recovery. Nesse…
(more)
▼ Como o processo de gaseificaÃÃo do glicerol adquire um balanÃo energÃtico desfavorÃvel, Ã sugerida a operaÃÃo de um gaseificador como dispositivo de heat recovery. Nesse contexto,
um reator de leito fixo à operado com gases de exaustÃo a uma temperatura de 820ÂC como fonte de energia e injeÃÃo eletrÃnica contÃnua de glicerol e Ãgua. O reator de leito fixo foi
construÃdo com aÃo inox AISI 310 e com capacidade volumÃtrica de 3,73 litros e como material poroso do leito a alumina com 1,5 mm de diÃmetro. O experimento utilizou termopar do tipo K, sensor de pressÃo piezoresistivo e controle de vazÃo mÃssica com sensor de alta precisÃo do tipo Coriolis. A composiÃÃo dos gases do produto, a demanda energÃtica da
gaseificaÃÃo e a eficiÃncia global do processo foram analisadas em funÃÃo da temperatura variando de 600 a 800 ÂC e a percentagem de glicerol na mistura variando de 30 a 90%. Para
determinar a viabilidade do projeto foi realizado um estudo energÃtico do processo utilizando o software EES (Engineering Equation Solver). Apesar de o reator ter sido construÃdo com
pequenas dimensÃes o objetivo do trabalho à obter resultados qualitativos para a gaseificaÃÃo do glicerol com praticidade, sem variÃveis de risco e dificuldades envolvidas em sistemas de
grande porte. O experimento mostrou uma boa conversÃo dos produtos em hidrogÃnio com valores acima de 50% em 750ÂC e proporÃÃo de 70% de glicerol em Ãgua e um gasto energÃtico de 36 MJ/g com uma eficiÃncia do processo prÃxima a 100%.
As the gasification process of glycerol acquires an unfavorable energy balance, the operation of a gasifier in heat recovery mode is suggested. In this context, a fixed bed reactor was operated with exhaust gases at a temperature of 820ÂC as energy source and continuous
electronic injection of glycerol and water. The fixed bed reactor was build with AISI 310 stainless steel and counted with a volumetric capacity of 3,713 liters and alumina with 1,5mm of diameter as the material of the porous bed. The experiments used K type thermocouples, piezoresistive pressure sensors and mass flow control based on a high
precision Coriolis sensor. The exhaust gases composition, the energy demand for gasification and the overall efficiency of the process were analyzed in a temperature range from 600 to 800ÂC and a glycerol percentage at the mixture ranging from 30 to 90%. To determine the
viability of the project, an energy study of the process was performed using the software EES (Engineering Equation Solver). Although the reactor was built using small dimensions, the objective of this work is to obtain qualitative results for the gasification of glycerol with
practicality, without risk variables and difficulties involved in large systems. The experiment showed a good conversion of products in hydrogen, presenting a conversion above 50% at a temperature of 750ÂC and with a proportion of 70% of glycerol in water and an energy waste of 36MJ/g with gasification efficiency nearby 100%.
Advisors/Committee Members: Paulo Alexandre Costa Rocha, Andrà Valente Bueno, Daniel Albiero.
Subjects/Keywords: ENGENHARIA MECANICA; Energia alternativa; Biodiesel; BiocombustÃvel; BalanÃo energÃtico; gasification; glycerol; reactor; continuous flow; energy balance
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APA (6th Edition):
Teixeira, P. L. L. (2012). GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8937 ;
Chicago Manual of Style (16th Edition):
Teixeira, Priscila Lane Lemos. “GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
.” 2012. Masters Thesis, Universidade Federal do Ceará. Accessed January 20, 2021.
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8937 ;.
MLA Handbook (7th Edition):
Teixeira, Priscila Lane Lemos. “GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
.” 2012. Web. 20 Jan 2021.
Vancouver:
Teixeira PLL. GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
. [Internet] [Masters thesis]. Universidade Federal do Ceará 2012. [cited 2021 Jan 20].
Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8937 ;.
Council of Science Editors:
Teixeira PLL. GaseificaÃÃo do Glicerol a Vapor em Leito Fixo e Meio Poroso NÃo CatalÃtico e CÃlculo do BalanÃo EnergÃtico
. [Masters Thesis]. Universidade Federal do Ceará 2012. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8937 ;
Temple University
28.
Newell, Mary Kathleen.
Effects of Movement Instruction on Children's Singing Achievement Scores.
Degree: PhD, 2013, Temple University
URL: http://digital.library.temple.edu/u?/p245801coll10,226345
► Music Education
The purpose of this research was to investigate the effects of movement instruction on children's singing achievement scores. When controlling for age, four…
(more)
▼ Music Education
The purpose of this research was to investigate the effects of movement instruction on children's singing achievement scores. When controlling for age, four overarching questions and nine sub-questions were asked. First, when controlling for age, how do pitch achievement scores at the outset compare to pitch achievement scores after movement instruction? 1) Is there a significant main effect of type of instruction on children's pitch achievement scores (between subjects)? 2) Is there a significant main effect of time on children's pitch achievement scores (within subjects)? 3) Is there a significant instruction and time interaction? Second, when controlling for age, how do rhythm achievement scores at the outset compare to rhythm achievement scores after movement instruction? 4) Is there a significant main effect of type of instruction on children's rhythmic achievement scores? 5) Is there a significant main effect of time on children's rhythmic achievement scores? 6) Is there a significant instruction and time interaction? Third, when controlling for age, how do singing voice development scores at the outset compare to scores after movement instruction? 7) Is there a significant main effect of type of instruction on children's singing voice development scores? 8) Is there a significant main effect of time on children's singing voice development scores? 9) Is there a significant instruction and time interaction? Fourth, descriptively, what is the effect of gender on students' pretest and posttest pitch achievement scores, rhythm achievement scores, and singing voice development measure scores? Second, third, and fourth grade students (N = 143) participated in the study. Subjects were randomly assigned to one of three treatment groups receiving different instruction: steady beat movement, continuous fluid movement, or a control group receiving no movement instruction. A researcher-designed criterion song was used as a pretest and posttest measure. Pitch and rhythm achievement scores were assessed using Praat Software. Three raters assessed singing performances using Rutkowski's Singing Voice Development Measure. Three split-plot Analyses of Covariance were run on the data. Results indicated that there was a significant interaction between treatment and time on pitch achievement scores. Post hoc analyses revealed no significant differences among treatment groups for pitch achievement scores. Results indicated that there was a significant interaction between treatment and time for Singing Voice Development Measure scores. Post hoc analyses revealed that the treatment group receiving continuous fluid movement significantly outscored the treatment group receiving steady beat movement. No significant differences were found on rhythm achievement scores. Descriptively, females outscored males on pitch, rhythm, and singing voice development measure scores for both pretest and posttest measures.
Temple University – Theses
Advisors/Committee Members: Reynolds, Alison M.;, Wright, Maurice, Sheldon, Deborah A., Dilworth, Rollo A., Cromley, Jennifer.
Subjects/Keywords: Music education; Music; Education;
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APA (6th Edition):
Newell, M. K. (2013). Effects of Movement Instruction on Children's Singing Achievement Scores. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,226345
Chicago Manual of Style (16th Edition):
Newell, Mary Kathleen. “Effects of Movement Instruction on Children's Singing Achievement Scores.” 2013. Doctoral Dissertation, Temple University. Accessed January 20, 2021.
http://digital.library.temple.edu/u?/p245801coll10,226345.
MLA Handbook (7th Edition):
Newell, Mary Kathleen. “Effects of Movement Instruction on Children's Singing Achievement Scores.” 2013. Web. 20 Jan 2021.
Vancouver:
Newell MK. Effects of Movement Instruction on Children's Singing Achievement Scores. [Internet] [Doctoral dissertation]. Temple University; 2013. [cited 2021 Jan 20].
Available from: http://digital.library.temple.edu/u?/p245801coll10,226345.
Council of Science Editors:
Newell MK. Effects of Movement Instruction on Children's Singing Achievement Scores. [Doctoral Dissertation]. Temple University; 2013. Available from: http://digital.library.temple.edu/u?/p245801coll10,226345
Universidade Estadual de Campinas
29.
Galaverna, Renan de Souza, 1989-.
Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry.
Degree: 2019, Universidade Estadual de Campinas
URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334868
► Abstract: This Ph.D. thesis aimed to evaluate the synthesis of high-added value compounds from biomass under continuous flow conditions. Among the works that will be…
(more)
▼ Abstract: This Ph.D. thesis aimed to evaluate the synthesis of high-added value compounds from biomass under
continuous flow conditions. Among the works that will be discussed, it was evaluated the synthesis of 5-(hydroxymethyl)furfural (5-HMF) using D-fructose as starting material in both batch (71%) and
continuous flow conditions (95%). In addition, both processes were evaluated by the Design of Experiment (DoE) and, for
flow process, online monitoring using a
flow FT-IR cell. In a second study, it was reported the coupling between the
continuous flow system with an ultra-compact and low-cost analytical technique (microNIR, $ 2,500) for the online monitoring of an organic transformation. For this purpose, a well-established reaction in our research group (5-HMF synthesis) was used in this application and demonstrated the robustness/reproducibility of the
flow-microNIR coupled system. In another study, it was also demonstrated an application using 5-HMF as starting material for the synthesis of a green resin (derived from biomass), in which it can be used as a heterogeneous acid catalyst for organic reactions. Continuing our interest in the field of biomass valorization, two libraries of terpene-based monomers were synthesized in
flow and such monomers were used for the production of green polyesters and polyamides. During the Ph.D., the student had an accepted scholarship in the CNPq program called Sandwich Doctorate Abroad (SWE). In that way, Cardiff University (UK) was chosen as abroad university and the student worked for 10 months under the supervision of Prof. Dr. Duncan L. Browne. During this period, the student was involved with the generation and application of reactive acylketene species for the synthesis of dioxinones, 1,3-dicarbonyl compounds, oxazine-diones, and coumarins in the
continuous flow process. In view of the foregoing, in general, this Ph.D. thesis focus on three major aspects of chemistry, which are; Green Chemistry,
Continuous Flow Chemistry, and Biomass Valorisation
Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Pastre, Júlio Cezar, 1979- (advisor), Universidade Estadual de Campinas. Instituto de Química (institution), Programa de Pós-Graduação em Química (nameofprogram), Coelho, Fernando Antonio Santos (committee member), Lucca Júnior, Emilio Carlos de (committee member), Oliveira, Kleber Thiago de (committee member), Burtoloso, Antonio Carlos Bender (committee member).
Subjects/Keywords: Fluxo contínuo; Química verde; Monômeros; Biomassa; Continuous flow regime; Green chemistry; Monomers; Biomass
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APA (6th Edition):
Galaverna, Renan de Souza, 1. (2019). Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/334868
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Galaverna, Renan de Souza, 1989-. “Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry.” 2019. Thesis, Universidade Estadual de Campinas. Accessed January 20, 2021.
http://repositorio.unicamp.br/jspui/handle/REPOSIP/334868.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Galaverna, Renan de Souza, 1989-. “Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry.” 2019. Web. 20 Jan 2021.
Vancouver:
Galaverna, Renan de Souza 1. Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry. [Internet] [Thesis]. Universidade Estadual de Campinas; 2019. [cited 2021 Jan 20].
Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334868.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Galaverna, Renan de Souza 1. Explorando os benefícios da química em fluxo contínuo na síntese de compostos oriundos de biomassa e na química de cetenos: Exploring the benefits of continuous flow chemistry in the synthesis of compounds from biomass and ketene chemistry. [Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334868
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
30.
Yang, Xi.
Tempered Fractional Derivative: Application to Linear Flow.
Degree: MS, Petroleum Engineering, 2018, Texas A&M University
URL: http://hdl.handle.net/1969.1/173986
► Hydraulic fracturing has become the dominant completion method in unconventional shale oil and gas reservoirs. The fluid flow inside unconventional shale reservoirs is different compared…
(more)
▼ Hydraulic fracturing has become the dominant completion method in unconventional shale oil and gas reservoirs. The fluid
flow inside unconventional shale reservoirs is different compared to conventional reservoirs. The importance of understanding anomalous diffusion of unconventional reservoir starts to appear. Traditional Darcy’s law is not appropriate to describe sub-diffusion behavior. In order to analytically model the sub-diffusion behavior,
continuous time random walk (CTRW) theory is introduced in some literature. Fractional derivative method is used to apply CTRW theory to the flux law and thus modelling sub-diffusion behavior. For
flow into fracture in unconventional reservoir, linear
flow regime is suitable not only for transient period but also for late-time period. Applying fractional derivative to the flux law successfully describes the sub-diffusion behavior in transient period. However, the flux law using fractional derivative causes inaccurate result for late-time period. In order to ameliorate the problem, we introduce a tempering factor into the fractional derivative. Then, tempering fractional derivative is applied to the flux law. This flux law is applied to linear
flow diffusivity equation and transferred into Laplace domain for solution. Real time domain solutions are obtained using GWR numerical inversion. In our study, model for single fracture is successfully created for two different boundary conditions. After verifying our model with numerical model and fractional linear
flow model, we are generating type curves for various fractional parameter and tempering factor parameter pairs. Furthermore, we analyze production data from three oil wells in Eagle Ford shale play using our tempered fractional linear
flow model.
Advisors/Committee Members: Valko, Peter (advisor), Blasingame, Thomas A. (committee member), Wu, Kan (committee member).
Subjects/Keywords: Linear Flow; Anomalous Diffusion; Sub-Diffusion; Unconventional Reservoir; Continuous Time Random Walk; Type Curve
Record Details
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Cite
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yang, X. (2018). Tempered Fractional Derivative: Application to Linear Flow. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173986
Chicago Manual of Style (16th Edition):
Yang, Xi. “Tempered Fractional Derivative: Application to Linear Flow.” 2018. Masters Thesis, Texas A&M University. Accessed January 20, 2021.
http://hdl.handle.net/1969.1/173986.
MLA Handbook (7th Edition):
Yang, Xi. “Tempered Fractional Derivative: Application to Linear Flow.” 2018. Web. 20 Jan 2021.
Vancouver:
Yang X. Tempered Fractional Derivative: Application to Linear Flow. [Internet] [Masters thesis]. Texas A&M University; 2018. [cited 2021 Jan 20].
Available from: http://hdl.handle.net/1969.1/173986.
Council of Science Editors:
Yang X. Tempered Fractional Derivative: Application to Linear Flow. [Masters Thesis]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173986
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Open Access Theses and Dissertations
