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Addis Ababa University
1.
Selamawit, Adugna.
Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
.
Degree: 2010, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/6709 
► Using a combination of qualitative and quantitative methods, this study identify the challenges of and opportunities from Access to ICTs from a gender perspective on…
(more)
▼ Using a
combination of qualitative and quantitative methods, this study identify the
challenges of and opportunities from Access to ICTs from a gender perspective on
selected residents of Arada Sub-city of Addis Ababa Administration. To this end, the
study investigated the situation regarding access to computer and internet, frequency
of using them, experience in using these technologies and place of use. The study
involved 140 (122 for questionnaire and 18 for interview) participants who were
selected from residents of Arada sub-city using convenience and purposive sampling
techniques. The result of the study has indicated that ICT is affected by different sociocultural
and economic status and there is a gender gap in having access to ICT as a
reflection of the gender disparity appears in the society. The study also find out
challenges in having access to computer and internet technology the majority of the
research respondents have indicated that access, experience, frequency, place and
purpose of using computer and internet technology is affected by gender, educational
attainment, income and age. Women have less access to computer and internet
technology due to many barriers, women have less economical power than the of
male, have less computer skill, have lots of responsibilities at home, shortage of time,
less connected to technologies, unawareness on ICT’s relevance to their life and not
know the benefit out of these technologies are the major findings from the survey and
the interview. In addition the participants notify that ICT’s bring a new opportunity in
their in their in their educational, social and professional life.
Advisors/Committee Members: Dr vijaya subramaniyam (advisor).
Subjects/Keywords: combination of qualitative
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APA (6th Edition):
Selamawit, A. (2010). Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/6709
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Selamawit, Adugna. “Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
.” 2010. Thesis, Addis Ababa University. Accessed July 19, 2019.
http://etd.aau.edu.et/dspace/handle/123456789/6709.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Selamawit, Adugna. “Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
.” 2010. Web. 19 Jul 2019.
Vancouver:
Selamawit A. Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
. [Internet] [Thesis]. Addis Ababa University; 2010. [cited 2019 Jul 19].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/6709.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Selamawit A. Challenges of and Opportunities from Access to Information and Communication Technology– A Gender Perspective Analysis on Arada Sub City, Addis Ababa
. [Thesis]. Addis Ababa University; 2010. Available from: http://etd.aau.edu.et/dspace/handle/123456789/6709
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Guelph
2.
Pal, Ritika.
The Combination Problem for Panpsychism and its Possible Solutions
.
Degree: 2019, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15942
► In this thesis I will talk about the combination problem of panpsychism and some possible solutions to it. A reductive approach (Dennett 1993, Churchland 2013)…
(more)
▼ In this thesis I will talk about the
combination problem of panpsychism and some possible solutions to it. A reductive approach (Dennett 1993, Churchland 2013) toward a theory of consciousness has not yielded satisfactory results because it fails to address the hard problem of consciousness (Chalmers 1995). A nonreductive approach acknowledges the hard problem and claims that consciousness is a property of the universe. Panpsychism is one such nonreductive approach to consciousness. However, a major roadblock for panpsychism is the
combination problem. My thesis will discuss the
combination problem and two possible solutions to it called the phenomenal bonding relation (Goff 2016) and the Space-Time-Qualia Complex (Skrbina 2011). I conclude that Skrbina’s Space-Time-Qualia Complex answers the
combination problem in a much better way than the phenomenal bonding solution and that is why it is an avenue worth exploring.
Advisors/Committee Members: Bailey, Andrew (advisor).
Subjects/Keywords: combination problem;
panpsychism
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APA (6th Edition):
Pal, R. (2019). The Combination Problem for Panpsychism and its Possible Solutions
. (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15942
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pal, Ritika. “The Combination Problem for Panpsychism and its Possible Solutions
.” 2019. Thesis, University of Guelph. Accessed July 19, 2019.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15942.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pal, Ritika. “The Combination Problem for Panpsychism and its Possible Solutions
.” 2019. Web. 19 Jul 2019.
Vancouver:
Pal R. The Combination Problem for Panpsychism and its Possible Solutions
. [Internet] [Thesis]. University of Guelph; 2019. [cited 2019 Jul 19].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15942.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pal R. The Combination Problem for Panpsychism and its Possible Solutions
. [Thesis]. University of Guelph; 2019. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15942
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Sathiyabama, S.
An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system.
Degree: Computer Science, 2014, Periyar University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/20615
► Recently mining from data streams has become an important and newlinechallenging task for many realworld applications The classification of large data set newlineis an important…
(more)
▼ Recently mining from data streams has become an
important and newlinechallenging task for many realworld
applications The classification of large data set newlineis an
important problem in data mining Noone classification technique is
always newlinesuperior to the others in terms of classification
accuracy In recent years some multiple newlineclassifier
combination techniques were proposed to improve the performance of
newlineclassifiers Multiple classifier
combination is a technique
of combining the decisions of newlinedifferent classifiers which
are trained to solve the same problem but make different
newlineerrors A proper
combination of multiple classifiers should
produce more reliable newlinerecognition of results than any of the
individual classifiers Hence multiple newlineindependent approaches
can be applied to a classification problem each yielding its
newlineown prediction The results of these techniques can then be
combined In the proposed newlinemethod the Decision tree classifier
K Nearest Neighbor and the Neural network newlineclassifiers are
constructed using a new technique known as Resampling based on
newlinethreshold RST These classifiers are combined based on the
newly proposed method newlineknown as Dynamic
Combination of
Multiple Classifiers system DCMCS to classify newlinea test
instance at run time newlineWhen constructing individual
classifiers the new technique RST has been newlineused to improve
the performance of classifier The databases considered for the
newlineanalysis are the Adult database and the Earthquake database
For both the databases newlinethe probability of occurrences of
every class for the entire training data set has been
newlineestimated Based on RST thresholds have been fixed for all
the classes When the data newlineset have been selected randomly
the probabilities of the classes have been checked newlineagainst
the thresholds If it does not satisfy the threshold Resampling is
performed newlineThe study made on three different classifiers
shows that the data set which satisfies the newlinethreshold for
all the classes produces better performance than the one which
doesnt newlinesatisfy the threshold The classifiers constructed
using the ran
Advisors/Committee Members: Duraiswamy, K.
Subjects/Keywords: DYNAMIC COMBINATION; MULTIPLE CLASSIFIERS
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APA (6th Edition):
Sathiyabama, S. (2014). An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system. (Thesis). Periyar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/20615
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sathiyabama, S. “An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system.” 2014. Thesis, Periyar University. Accessed July 19, 2019.
http://shodhganga.inflibnet.ac.in/handle/10603/20615.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sathiyabama, S. “An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system.” 2014. Web. 19 Jul 2019.
Vancouver:
Sathiyabama S. An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system. [Internet] [Thesis]. Periyar University; 2014. [cited 2019 Jul 19].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/20615.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sathiyabama S. An efficient implementation of re sampling technique for
the dynamic combination of multiple classifiers system. [Thesis]. Periyar University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/20615
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
4.
Zhang, Qinrong.
A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment.
Degree: 2017, University of Waterloo
URL: http://hdl.handle.net/10012/11272
► Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers, including ovarian…
(more)
▼ Cisplatin is the first and most widely used platinum-based chemotherapy drug and is the cornerstone agent in treating a broad spectrum of cancers, including ovarian cancer, testicular cancer, cervical cancer, bladder cancer, lung cancer, head and neck cancer, lymphoma, and brain tumors. It is one of the few curative anti-cancer agents; however, its clinical application is often limited by severe toxic side effects and resistance possessed by some cancers.
Our group has recently, through the femtomedicine approach, unraveled a new molecular mechanism of Cisplatin. It has been found that Cisplatin is extremely effective for the dissociative electron transfer (DET) reaction with weakly-bound electrons to produce reactive radicals that cause DNA strand breaks, apoptosis, and final clonogenic cell kill.
Based on this DET mechanism, it is proposed that Cisplatin may be administered in combination with a biological electron donor to enhance its chemotherapeutic efficacy. We have tried a few combinations of Cisplatin and electron-donating compounds. In this thesis, we show results of the combination: Cisplatin and Rhodamine-B, the one with the greatest potential as demonstrated in both in vitro assays and in vivo xenograft mouse cancer models. This thesis begins with an introduction to cancer and cancer therapies in Chapter 1, where the theory, objective, and scope of this thesis are introduced. Chapter 2 focuses on some new understandings of Cisplatin-induced DNA damage. In vitro and in vivo experiment results on the effectiveness of the combination of Cisplatin and Rhodamine-B are presented in Chapter 3 and Chapter 4, respectively. In Chapter 5, time-resolved femtosecond laser spectroscopic studies on the reaction between Cisplatin and Rhodamine-B are shown. Chapter 6 as the last Chapter summarizes results obtained in this project and proposes some possible future research.
In vitro experiments confirm the potential of this proposed combination of Cisplatin and Rhodamine-B to treat cancer. From cell survival tests, by applying MTT assays and clonogenic assays, it has been shown that our proposed combination significantly enhances the cell-killing efficacy in cancer cells; but surprisingly, not in normal cells. Besides, plasmid DNA gel electrophoresis and γ-H2AX staining in treated cells indicate that more double-strand breaks can be induced using our combination, compared to Cisplatin only. In addition, measurements on Caspase 3/7 activation and Annexin V-FITC labeling flow cytometry experiments clearly show a significant enhancement in the population of apoptotic cells using our combination. To further verify the effectiveness of the combination of Cisplatin and Rhodamine-B, in vivo xenograft mouse models have been developed. Our combination greatly enhances the tumor growth inhibition and even tumor shrinkage in three different mouse models. Acute toxicity analysis and body weight measurements do not show additional side effects induced by the addition of Rhodamine-B. Lastly, spectroscopic measurements…
Subjects/Keywords: Cancer; Combination Therapy; Cisplatin
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Manager
APA (6th Edition):
Zhang, Q. (2017). A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/11272
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Qinrong. “A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment.” 2017. Thesis, University of Waterloo. Accessed July 19, 2019.
http://hdl.handle.net/10012/11272.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Qinrong. “A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment.” 2017. Web. 19 Jul 2019.
Vancouver:
Zhang Q. A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment. [Internet] [Thesis]. University of Waterloo; 2017. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/10012/11272.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang Q. A Novel Combination Therapy of Cisplatin with a Molecular Promoter for Cancer Treatment. [Thesis]. University of Waterloo; 2017. Available from: http://hdl.handle.net/10012/11272
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Southern California
5.
Wan, Shui-Ki.
Essays on the econometrics of program evaluation.
Degree: PhD, Economics, 2010, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/331132/rec/2479
► Many empirical literature in economics, social sciences, and medical treatment studies the causal effects of programs, polices or drug effects. In the economic context, the…
(more)
▼ Many empirical literature in economics, social
sciences, and medical treatment studies the causal effects of
programs, polices or drug effects. In the economic context, the
major focus on program evaluation literature is to measure the
impact of a particular treatment on a set of individuals, regions,
or countries that exposed to such a treatment. It is of particular
importance to policy makers, medical practitioners and others. In
order to evaluate the effect of the treatment, Rubin (1974)
proposed the interpretation of causal statements as comparisons of
the so-called potential outcomes, which is de
fined as a pair of
outcomes associated to a particular individual given different
levels of exposure to the treatment with only one of the outcomes
observed by researchers. Models are developed for this pair of
potential outcomes one for the treated state, another for the
control state. In this thesis, a panel data methodology is proposed
under the potential outcomes framework to measure the average
treatment effect. This methodology is applied to measure the impact
of two major Hong Kong polices on the Hong Kong s' economy. Due to
the model uncertainty involved in forming the counterfactual,
forecast
combination methods are proposed as a way to reduce this
uncertainty. Various existing methods together with some new
proposed methods are evaluated in a small scale Monte Carlo studies
and two applications.
Advisors/Committee Members: Hsiao, Cheng (Committee Chair), Dekle, Robert (Committee Member), Luo, Lan (Committee Member).
Subjects/Keywords: program evaluation; forecast combination
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APA (6th Edition):
Wan, S. (2010). Essays on the econometrics of program evaluation. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/331132/rec/2479
Chicago Manual of Style (16th Edition):
Wan, Shui-Ki. “Essays on the econometrics of program evaluation.” 2010. Doctoral Dissertation, University of Southern California. Accessed July 19, 2019.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/331132/rec/2479.
MLA Handbook (7th Edition):
Wan, Shui-Ki. “Essays on the econometrics of program evaluation.” 2010. Web. 19 Jul 2019.
Vancouver:
Wan S. Essays on the econometrics of program evaluation. [Internet] [Doctoral dissertation]. University of Southern California; 2010. [cited 2019 Jul 19].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/331132/rec/2479.
Council of Science Editors:
Wan S. Essays on the econometrics of program evaluation. [Doctoral Dissertation]. University of Southern California; 2010. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/331132/rec/2479
Northeastern University
6.
Costa, Daniel Ferreira Gomes.
Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy.
Degree: PhD, School of Pharmacy, 2018, Northeastern University
URL: http://hdl.handle.net/2047/D20293411
► Conventional drugs have for long been investigated as potential therapeutic agents for the treatment of cancer, one of the leading causes of death worldwide. Recently,…
(more)
▼ Conventional drugs have for long been investigated as potential therapeutic agents for the treatment of cancer, one of the leading causes of death worldwide. Recently, combination of these drugs with small non-coding RNAs has become a promising strategy to overcome the development of drug resistance. Additionally, the use of stimuli-sensitive drug delivery systems has emerged as a strategy to improve targeting of diseased tissues and reduce the damage to non-targeted organs.; The general aim of this study was to develop, characterize and test a pharmaceutical preparation whose action is triggered by the enzymatic activity and redox conditions typical of tumor microenvironments. We hypothesized that overexpression of matrix metalloproteinase 2 (MMP2) and glutathione (GSH) in the tumor would guarantee a targeted delivery of Doxorubicin (Dox) and miRNA-34a, increasing bioavailability of both therapeutic agents and reducing off-target effects.; A Dox prodrug and lipid-modified miRNA-34a were successfully synthesized and incorporated into mixed micelles (MM). The stimuli-sensitivity of both components was demonstrated in monolayer and spheroid models of cell culture in vitro. The level of MMP2 expression was a key factor to determine the localization of the Dox prodrug in the cytoplasm or cell nuclei. The cytotoxic effect in a monolayer model of soft tissue sarcoma was as high as 80%. The prodrug was also effective against breast adenocarcinoma and glioblastoma. The treatment with MMP2-sensitive MM significantly reduced cell motility and migration when compared to group control.; GSH-sensitive MM lowered mRNA levels of survivin (» 55%), Bcl2 (» 65%) and notch1 (» 45%) in soft tissue sarcoma cells. Combination therapy with Dox prodrug and miRNA-34a inhibited over 90% of Bcl2 production. Dual stimuli-sensitive MM killed 2.4 to 3.6 times more cells compared to the single treatments by arresting the cells in S phase of their cell cycle.; In vivo trials in tumor-bearing mice significantly inhibited growth of soft tissue sarcoma and glioblastoma xenografts and avoided weight loss caused by free Dox.
Subjects/Keywords: combination therapy; doxorubicin; micelles; miRNA
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APA (6th Edition):
Costa, D. F. G. (2018). Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20293411
Chicago Manual of Style (16th Edition):
Costa, Daniel Ferreira Gomes. “Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy.” 2018. Doctoral Dissertation, Northeastern University. Accessed July 19, 2019.
http://hdl.handle.net/2047/D20293411.
MLA Handbook (7th Edition):
Costa, Daniel Ferreira Gomes. “Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy.” 2018. Web. 19 Jul 2019.
Vancouver:
Costa DFG. Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy. [Internet] [Doctoral dissertation]. Northeastern University; 2018. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/2047/D20293411.
Council of Science Editors:
Costa DFG. Multi-targeted stimuli-sensitive mixed micelles as a strategy for cancer therapy. [Doctoral Dissertation]. Northeastern University; 2018. Available from: http://hdl.handle.net/2047/D20293411
University of KwaZulu-Natal
7.
Ngubane, Thandazile Iris.
Teachers teaching multi-grade classes in a rural setting.
Degree: M. Ed., Education, 2011, University of KwaZulu-Natal
URL: http://hdl.handle.net/10413/9223
► This study aims to explore the experiences of teaching foundation phase multi-grade classes in rural settings. I am interested in understanding how teachers teach multi-grade…
(more)
▼ This study aims to explore the experiences of teaching foundation phase multi-grade classes in rural settings. I am interested in understanding how teachers teach multi-grade classes so that I am able to make sense of the challenges and opportunities that they encounter. This is a qualitative case study and is guided by the interpretive paradigm. Purposeful sampling was used to select participants.
I collected data by using qualitative research methods including interviews and observations. Interviews were audio-taped, transcribed and interpreted through an open coding process. Data was synthesised and resulted in the formulation of five themes.
The findings show that teachers were faced with challenges which include lack of proper training, insufficient support from stakeholders, no workshops organised for multi-grade teachers, lack of resources at school which makes teaching and learning difficult, conditions of the school and the community that are not conducive to effective teaching and learning. Recommendations include that multi-grade teachers need to receive ongoing support from stakeholders. They also need to be given pre- and in-service training so that they are aware of strategies they can use to overcome challenges that they encounter when teaching. The Department of Education needs to provide relevant support for the benefit of the learners and the community.
Advisors/Committee Members: Ramrathan, Prevanand (advisor).
Subjects/Keywords: Education.; Combination of grades.; Education – Curricula.
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APA (6th Edition):
Ngubane, T. I. (2011). Teachers teaching multi-grade classes in a rural setting. (Masters Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/9223
Chicago Manual of Style (16th Edition):
Ngubane, Thandazile Iris. “Teachers teaching multi-grade classes in a rural setting.” 2011. Masters Thesis, University of KwaZulu-Natal. Accessed July 19, 2019.
http://hdl.handle.net/10413/9223.
MLA Handbook (7th Edition):
Ngubane, Thandazile Iris. “Teachers teaching multi-grade classes in a rural setting.” 2011. Web. 19 Jul 2019.
Vancouver:
Ngubane TI. Teachers teaching multi-grade classes in a rural setting. [Internet] [Masters thesis]. University of KwaZulu-Natal; 2011. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/10413/9223.
Council of Science Editors:
Ngubane TI. Teachers teaching multi-grade classes in a rural setting. [Masters Thesis]. University of KwaZulu-Natal; 2011. Available from: http://hdl.handle.net/10413/9223
University of Georgia
8.
Al-Husein, Belal Abdelaziz Abdeljalil.
Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo.
Degree: PhD, Pharmacy, 2013, University of Georgia
URL: http://purl.galileo.usg.edu/uga_etd/al-husein_belal_a_201305_phd
► Prostate cancer is a leading killer in the United States. Lack of understanding of mechanisms of disease proliferation, progression and metastasis is a major hindrance…
(more)
▼ Prostate cancer is a leading killer in the United States. Lack of understanding of mechanisms of disease proliferation, progression and metastasis is a major hindrance in the proper management of this disease. Statins are drugs with known pleiotropy that could justify their introduction into various clinical conditions. Many clinical studies showed beneficial effects of statins in reducing prostate cancer progression and, to a lesser extent, development. In this research, the effect of simvastatin, a potent lipophilic statin, and the mechanism of its effect on prostate cancer cells is studied in vitro and in vivo. Results show promising effects of simvastatin on human prostate cancer proliferation, colony formation and migration, in both androgen-dependent and –independent disease. Effects were tested in vivo and showed a reduction of tumor size in simvastatin treated nude mice compared to controls. Mechanism of effect of simvastatin on cancer cell micrometastasis was also studied using ECIS, gene arrays,
adhesion assays immunocytochemistry and western blotting and showed its effect on integrin αvβ3 activation and consequently adhesion, as well as impairment of tumor secreted factor effect, in addition to stabilization of endothelial barrier. In this research we also studied the effect of
combination on proliferation and migration in vitro as well as on tumor growth in vivo and showed promising effect with a highly significant reduction of proliferation, migration and tumor growth compared to controls. In conclusion, our pre-clinical research shows beneficial effect of simvastatin alone or in
combination with docetaxel in the management of prostate cancer and prevention of micrometastasis.
Advisors/Committee Members: Somanath Shenoy.
Subjects/Keywords: STATINS; SIMVASTATIN; PROSTATE CANCER; MICROMETASTASIS; DOCETAXEL; COMBINATION.
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APA (6th Edition):
Al-Husein, B. A. A. (2013). Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/al-husein_belal_a_201305_phd
Chicago Manual of Style (16th Edition):
Al-Husein, Belal Abdelaziz Abdeljalil. “Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo.” 2013. Doctoral Dissertation, University of Georgia. Accessed July 19, 2019.
http://purl.galileo.usg.edu/uga_etd/al-husein_belal_a_201305_phd.
MLA Handbook (7th Edition):
Al-Husein, Belal Abdelaziz Abdeljalil. “Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo.” 2013. Web. 19 Jul 2019.
Vancouver:
Al-Husein BAA. Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo. [Internet] [Doctoral dissertation]. University of Georgia; 2013. [cited 2019 Jul 19].
Available from: http://purl.galileo.usg.edu/uga_etd/al-husein_belal_a_201305_phd.
Council of Science Editors:
Al-Husein BAA. Molecular mechanisms regulating simvastatin-mediated inhibition of prostate cancer cellular functions in vitro and tumor growth in vivo. [Doctoral Dissertation]. University of Georgia; 2013. Available from: http://purl.galileo.usg.edu/uga_etd/al-husein_belal_a_201305_phd
9.
Slezák Ondřej.
Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
.
Degree: 2012, Czech University of Technology
URL: http://hdl.handle.net/10467/13343
Self-navigation of laser beams on IFE targets using SBS PCM; Self-navigation of laser beams on IFE targets using SBS PCM
Advisors/Committee Members: Kálal Milan (advisor).Subjects/Keywords: Brillouin scattering; laser fusion; laser beam combination
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APA (6th Edition):
Ondřej, S. (2012). Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
. (Thesis). Czech University of Technology. Retrieved from http://hdl.handle.net/10467/13343
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ondřej, Slezák. “Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
.” 2012. Thesis, Czech University of Technology. Accessed July 19, 2019.
http://hdl.handle.net/10467/13343.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ondřej, Slezák. “Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
.” 2012. Web. 19 Jul 2019.
Vancouver:
Ondřej S. Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
. [Internet] [Thesis]. Czech University of Technology; 2012. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/10467/13343.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ondřej S. Self-navigation of laser beams on injected IFE targets using SBS PCM technology: conceptual design of the method
. [Thesis]. Czech University of Technology; 2012. Available from: http://hdl.handle.net/10467/13343
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
10.
Agah, Shima.
Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation.
Degree: PhD, Food Science and Technology, 2016, Texas A&M University
URL: http://hdl.handle.net/1969.1/156860
► Sorghum and cowpea contain structurally distinct flavonoids that may provide complementary bioactive properties. This study investigated the interactive effects of combining sorghum and cowpea flavonoids…
(more)
▼ Sorghum and cowpea contain structurally distinct flavonoids that may provide complementary bioactive properties. This study investigated the interactive effects of combining sorghum and cowpea flavonoids on inflammation and reactive oxygen species (ROS) generation in non-malignant colon myofibroblasts (CCD-18Co). The effect of sorghum-cowpea flavonoid combinations on ATP binding cassette (ABC) transporter proteins in Caco-2 cell model was also investigated.
The White sorghum-white cowpea extract combinations at (0.1 ?g/mL) synergistically (1.5-2 times) attenuated LPS-induced ROS generation as well as LPS-induced inflammation in non-cancer CCD-18Co cells by inhibiting the activation of NF-?B and related downstream targets such as IL-6, IL-8 and TNF-? at both mRNA and protein levels.
Combination of pure apigenin (dominant flavonoid in white sorghum) and quercetin (prevalent flavonoid in white cowpea) demonstrated similar enhanced action (1.5-2 times) in protecting the CCD-18Co cells against ROS generation and inflammation at 0.1 ?M, indicating the flavones and flavonols in sorghum-cowpea mixtures may be responsible for the observed synergistic effect. The magnitude of synergy was strongly dependent on the relative ratios of sorghum-cowpea and apigenin-quercetin mixtures, which suggests different mechanisms of action for the flavones and flavonols.
The White sorghum-white cowpea as well as apigenin-quercetin combinations synergistically modified the activity of efflux transporters in Caco-2 cell monolayers by inhibiting the expression of apically located ABC transporters including BCRP, MRP2, MRP3 and MDR1 at both mRNA and protein levels. These results suggest that synergistic down-regulation of efflux transporter proteins could be a mechanism for enhanced action sorghum-cowpea
combination against inflammation.
Overall findings from these studies suggest that consuming sorghum and cowpea together may favorably influence health outcomes beyond what can be predicted from individual commodity. This is important because cereal and legumes are usually consumed together; strategic cereal and legume combinations might be formulated for optimized benefits in chronic disease prevention.
Further in vivo studies with sorghum-cowpea diets are required to assess the physiological effects of sorghum-cowpea flavonoids mixtures on biomarkers of inflammation and chronic disease.
Advisors/Committee Members: Awika, Joseph M (advisor), Talcott, Susanne U (committee member), Murano, Peter S (committee member), Patil, Bhimanagouda (committee member).
Subjects/Keywords: enhanced action; sorghum and cowpea; combination; inflammation
Record Details
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APA (6th Edition):
Agah, S. (2016). Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156860
Chicago Manual of Style (16th Edition):
Agah, Shima. “Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation.” 2016. Doctoral Dissertation, Texas A&M University. Accessed July 19, 2019.
http://hdl.handle.net/1969.1/156860.
MLA Handbook (7th Edition):
Agah, Shima. “Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation.” 2016. Web. 19 Jul 2019.
Vancouver:
Agah S. Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/1969.1/156860.
Council of Science Editors:
Agah S. Enhanced Action of Sorghum and Cowpea Flavonoid Mixtures Against Inflammation. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/156860
Texas A&M University
11.
Brandt, Alex Lamar.
In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials.
Degree: 2011, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7520
► Listeria monocytogenes is a foodborne pathogenic bacterium responsible for ~500 deaths and a financial burden of ~$2.3 billion each year in the United States. Though…
(more)
▼ Listeria monocytogenes is a foodborne pathogenic bacterium responsible for ~500
deaths and a financial burden of ~$2.3 billion each year in the United States. Though a zero
tolerance policy is enforced with regard to its detection in cooked ready-to-eat foods, additional
preemptive control alternatives are required for certain products. Among these alternatives are
strategies permitting the usage of food antimicrobial combinations to control the pathogen.
Research on antimicrobial combinations can provide insight into more efficient control of the
pathogen, but is currently lacking.
The purpose of this study was to evaluate the in vitro inhibition of L. monocytogenes
exposed to the antimicrobials e-Poly-L-Lysine (EPL), lauric arginate ester (LAE), and sodium
lactate (SL) at pH 7.3, octanoic acid (OCT) at pH 5.0, and nisin (NIS) and acidic calcium sulfate
(ACS) at both pH 5.0 and 7.3. A broth dilution assay was used to determine single antimicrobial
minimum inhibitory and bactericidal concentrations for L. monocytogenes Scott A, 310, NADC
2783, and NADC 2045. Optical density differences (delta<0.05 at 630 nm) were used to denote
inhibition. Concentrations producing population decreases of greater than or equal to 3.0 log10 CFU/ml after incubation
were considered bactericidal.
Inhibition resulting from combinations of antimicrobials (NIS+ACS, EPL+ACS,
SL+ACS, NIS+LAE, OCT+ACS, and OCT+NIS) was assessed using a checkerboard assay, and fractional inhibitory concentrations (FIC) were determined. FIC values were plotted on
isobolograms and were used to create FIC indices (FICI). Isobologram curvature was used to
classify combinations as synergistic, additive, or antagonistic. From FIC indices, interactions
were defined as antagonistic (FICI >1.0), additive (FICI =1.0), or synergistic (FICI <1.0).
Strain-dependent factors had a bearing on MIC and MBC values for NIS and EPL. At
pH 7.3, NIS+ACS displayed synergistic inhibition, NIS+LAE and EPL+ACS demonstrated
additive-type interactions, and the SL+ACS pairing was unable to be defined. At pH 5.0,
interpretation of the OCT+NIS interaction also presented challenges, while the OCT+ACS
combination resulted in synergistic behavior.
Additional studies are needed to validate in vitro findings on surfaces of ready-to-eat
meats. Future in vivo studies should investigate the ability of synergistic combinations
(NIS+ACS and OCT+ACS) to control the pathogen. Better characterizations of inhibitory
mechanisms should also be performed.
Advisors/Committee Members: Taylor, Thomas M. (advisor), Hardin, Margaret D. (committee member), Keeton, Jimmy T. (committee member).
Subjects/Keywords: Listeria monocytogenes; antimicrobial; in vitro; combination; synergistic
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CSE |
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APA (6th Edition):
Brandt, A. L. (2011). In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7520
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Brandt, Alex Lamar. “In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials.” 2011. Thesis, Texas A&M University. Accessed July 19, 2019.
http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7520.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Brandt, Alex Lamar. “In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials.” 2011. Web. 19 Jul 2019.
Vancouver:
Brandt AL. In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials. [Internet] [Thesis]. Texas A&M University; 2011. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7520.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Brandt AL. In Vitro Inhibition of Listeria Monocytogenes by Novel Combinations of Food Antimicrobials. [Thesis]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7520
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
12.
Miller, Daniel Evan.
A Combined Skeleton Model.
Degree: 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/154163
► Skeleton representations are a fundamental way of representing a variety of solid models. They are particularly important for representing certain biological models and are often…
(more)
▼ Skeleton representations are a fundamental way of representing a variety of solid models. They are particularly important for representing certain biological models and are often key to visualizing such data. Several methods exist for extracting skeletal models from 3D data sets. Unfortunately, there is usually not a single correct definition for what makes a good skeleton, and different methods will produce different skeletal models from a given input. Furthermore, for many scanned data sets, there also is inherent noise and loss of data in the scanning process that can reduce ability to identify a skeleton.
In this document, I propose a method for combining multiple algorithms' skeleton results into a single composite skeletal model. This model leverages various aspects of the geometric and topological information contained in the different input skeletal models to form a single result that may limit the error introduced by particular inputs by means of a confidence function. Using such an uncertainty based model, one can better understand, refine, and de-noise/simplify the skeletal structure. The following pages describe methods for forming this composite model and also examples of applying it to some real-world data sets.
Advisors/Committee Members: Keyser, John (advisor), Choe, Yoonsuck (committee member), Schaefer, Scott (committee member), Abbott, Louise (committee member).
Subjects/Keywords: skeleton; uncertainty; similarity estimation; geometric combination
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Export
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Manager
APA (6th Edition):
Miller, D. E. (2014). A Combined Skeleton Model. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/154163
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Miller, Daniel Evan. “A Combined Skeleton Model.” 2014. Thesis, Texas A&M University. Accessed July 19, 2019.
http://hdl.handle.net/1969.1/154163.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Miller, Daniel Evan. “A Combined Skeleton Model.” 2014. Web. 19 Jul 2019.
Vancouver:
Miller DE. A Combined Skeleton Model. [Internet] [Thesis]. Texas A&M University; 2014. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/1969.1/154163.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Miller DE. A Combined Skeleton Model. [Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/154163
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
13.
Vasuki S.
BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;.
Degree: Physiology, 2007, Sri Ramachandra University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/32010
► Diabetes mellitus is currently one of the most costly and burdensome chronic newlinediseases and is a condition that is increasing in epidemic proportions throughout the…
(more)
▼ Diabetes mellitus is currently one of the most
costly and burdensome chronic newlinediseases and is a condition
that is increasing in epidemic proportions throughout the
newlineworld (King et al., 1998). The diabetes pandemic mostly
affects the developing newlinecountries like India. India now
stands second, next to china with the largest number newlineof
diabetic patients in the world. newlineAccording to the
International Diabetes Federation (IDF) Diabetes Atlas
newline(2011), there were an estimated 61.3 million persons with
diabetes in India and this newlinenumber is predicted to rise to
almost 101.2 million persons by 2030. The studies on newlineIndian
population (Gupta, 2008) showed that the major risk factor for high
prevalence newlineof type 2 diabetes mellitus are, genetic
predisposition, insulin resistance, obesity, newlinecentral obesity
(greater abdominal adiposity), urbanisation with change in diet
habits newlineand sedentary life style. Rapid urbanisation and
industrialisation in developing newlinecountries such as India have
resulted in dramatic lifestyle changes leading to lifestyle
newlinerelated diseases. Certain unique clinical and biochemical
characteristics of this ethnic newlinegroup collectively called as
the Asian Indian phenotype is considered to be one of newlinethe
major factors contributing to the increased predilection towards
diabetes and it is newlineestimated that every fifth person with
diabetes will be an Indian (Mohan et al., 2007). newlineDiabetes is
one of the world s leading chronic diseases and has serious social
newlineand economic consideration. Billions of dollars are spent
every year by healthcare newlinesystem for treating diabetes and
its complications. International Diabetes Federation newline(IDF)
Diabetes atlas (2011) reported that the prevalence of diabetes
worldwide has newlineraised and the number would rise from 244.2
million in 2011 to 363 million in 2030. newline
Summary, p. 1-7 Reference p. 1-22 Appendix,
1-9
Advisors/Committee Members: Subhashini A S Dr.
Subjects/Keywords: ANTIDIABETIC PROPERTIES; EFFICACY AND SAFETY; POLYHERBAL COMBINATION
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APA (6th Edition):
S, V. (2007). BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;. (Thesis). Sri Ramachandra University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/32010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
S, Vasuki. “BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;.” 2007. Thesis, Sri Ramachandra University. Accessed July 19, 2019.
http://shodhganga.inflibnet.ac.in/handle/10603/32010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
S, Vasuki. “BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;.” 2007. Web. 19 Jul 2019.
Vancouver:
S V. BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;. [Internet] [Thesis]. Sri Ramachandra University; 2007. [cited 2019 Jul 19].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/32010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
S V. BIOLOGY GUIDED VALIDATION OF A POLYHERBAL COMBINATION
WITH ANTIDIABETIC PROPERTIES FOR EFFICACY AND SAFETY;. [Thesis]. Sri Ramachandra University; 2007. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/32010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Nelson Mandela Metropolitan University
14.
Subramanien, Brenda.
Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation.
Degree: MEd, Faculty of Education, 2013, Nelson Mandela Metropolitan University
URL: http://hdl.handle.net/10948/d1021039
► This interpretive exploratory case study investigated the challenges and barriers to the multi-grade context in general, as well as to Information and Communication Technology (ICT)…
(more)
▼ This interpretive exploratory case study investigated the challenges and barriers to the multi-grade context in general, as well as to Information and Communication Technology (ICT) implementation in a multi-grade context. Possible solutions based on teacher perceptions were generated inductively within a three-level typology. The research took place in three phases. Pre-training data were gathered in the first phase, using an open-ended questionnaire (all participants: n=20); personal interviews (n=9); and two focus group interviews, which consisted of three participants per focus group. Training on the Intel® Teach ICT programme and the provision of laptops (one per teacher) constituted the second phase. The third phase included post-training data generation using an open-ended questionnaire (all participants) and two focus group interviews, which consisted of three participants per focus group, to elicit teacher perceptions of the training programme and their use of the laptops in the classroom after the training. The findings suggest that first order (school or meso level) challenges pertaining to multi-grade teaching relate to the lack of resources; curriculum challenges; learner related challenges; isolation, impact on communication and teaching; time constraints; and a work overload as a result of the multiple roles. Second order challenges (self or micro level) related to the perceived uncaring attitude of the Department of Basic Education that left teachers feeling hurt and neglected; the unpreparedness for the multi-grade context which demotivated teachers; and the negative perceptions the teachers had about their learners. Third order challenges (system level, beyond the school level or micro level) were related to the lack of Departmental support from officials; the lack of curriculum training for the multi-grade context; and the lack of support on various fronts. Regarding ICT related challenges, the findings suggest that first order barriers related to the lack of suitable infrastructure for ICT implementation; lack of peer support; lack of access to appropriate hardware and software; and lack of time. Second order barriers related to the negative beliefs in the self; negative perceptions about the learners’ ability to use the laptop; and negative beliefs related to teaching and learning. The third order barriers were related to the lack of support and assistance from the Department of Basic Education for ICT implementation. The findings suggest that the participants viewed the provisioning of enabling programmes for parents as an important solution to first order challenges, and a change in mindset as the most important solution for second order problems. Third order solutions included a “multi-grade Renaissance” towards a new model for multi-grade teaching; re-thinking the curriculum requirements regarding multi-grade teaching by the Department of Basic Education; increased support and training from the Department; incentives to teach with ICT in the multi-grade context; encouraging further research…
Advisors/Committee Members: Du Plessis, André Dr.
Subjects/Keywords: Combination of grades; Information technology projects
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APA (6th Edition):
Subramanien, B. (2013). Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation. (Masters Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1021039
Chicago Manual of Style (16th Edition):
Subramanien, Brenda. “Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation.” 2013. Masters Thesis, Nelson Mandela Metropolitan University. Accessed July 19, 2019.
http://hdl.handle.net/10948/d1021039.
MLA Handbook (7th Edition):
Subramanien, Brenda. “Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation.” 2013. Web. 19 Jul 2019.
Vancouver:
Subramanien B. Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation. [Internet] [Masters thesis]. Nelson Mandela Metropolitan University; 2013. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/10948/d1021039.
Council of Science Editors:
Subramanien B. Exploring teachers' perceptions of the barriers and solutions to using one teacher laptop per class in a multi-grade context : the case of Intel®Teach-ICT implementation. [Masters Thesis]. Nelson Mandela Metropolitan University; 2013. Available from: http://hdl.handle.net/10948/d1021039
Durham University
15.
Davidson, Oliver Geoffrey.
The interpretation of noun noun compounds.
Degree: 1996, Durham University
URL: http://etheses.dur.ac.uk/5301/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337937
► This thesis looks at conceptual combination, in particular it investigates how noun noun compounds are interpreted. Several themes run throughout the work. Real compounds (e.g.…
(more)
▼ This thesis looks at conceptual combination, in particular it investigates how noun noun compounds are interpreted. Several themes run throughout the work. Real compounds (e.g. coat hanger, crab apple) are compared to novel ones (e.g. banjo cactus, zip violin). Also, compounds are examined in each of the possible permutations of artefacts (A) (e.g. coat, banjo) and natural kinds (N) (e.g. crab, cactus), (AA, AN, NA and NN).Experiments 1 - 4 examine noncompositionality in noun noun compounds. Possible sources of noncompositionality are investigated using both feature listing and feature rating tasks. Although some differences were found, results were similar between different types of compound, evidence of noncompositionality being found in each. The results also confirm that most of the meaning of a noun noim compound is derived from the second constituent (noun2).Experiments 5 and 6 look at two different types of compoimd interpretation - slot filling and property mapping. In experiment 5, slot filling is found to be the preferred interpretation type overall, but property mapping is more common in compounds composed of two natural kinds (NN). Experiment 6 examines possible factors influencing the choice between slot filling and property mapping interpretations. It was found that constituent similarity plays an important role, and also that this interacts with whether or not the constituents have important properties which clash. Experiment 7 looks at compound identification. Results suggest that the first constituent (nounl) may be critical in such tasks. Experiment 8 compares the importance of nounl and noun2 in determining the type of interpretation given to a compound. Neither position is found to be more influential than the other, although relational information does seem to be associated with specific nouns in each position. Throughout the thesis findings are related to current theories of conceptual combination, such as prototype models, the concept specialisation model and theories of compound interpretation by analogy.
Subjects/Keywords: 150; Concept combination
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APA (6th Edition):
Davidson, O. G. (1996). The interpretation of noun noun compounds. (Doctoral Dissertation). Durham University. Retrieved from http://etheses.dur.ac.uk/5301/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337937
Chicago Manual of Style (16th Edition):
Davidson, Oliver Geoffrey. “The interpretation of noun noun compounds.” 1996. Doctoral Dissertation, Durham University. Accessed July 19, 2019.
http://etheses.dur.ac.uk/5301/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337937.
MLA Handbook (7th Edition):
Davidson, Oliver Geoffrey. “The interpretation of noun noun compounds.” 1996. Web. 19 Jul 2019.
Vancouver:
Davidson OG. The interpretation of noun noun compounds. [Internet] [Doctoral dissertation]. Durham University; 1996. [cited 2019 Jul 19].
Available from: http://etheses.dur.ac.uk/5301/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337937.
Council of Science Editors:
Davidson OG. The interpretation of noun noun compounds. [Doctoral Dissertation]. Durham University; 1996. Available from: http://etheses.dur.ac.uk/5301/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337937
Universiteit Utrecht
16.
Smit, B.C.M.
Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten.
Degree: 2016, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/328809
► Introductie In dit onderzoek is het verband tussen persoonlijkheid en conflict in broer/zus-relaties onderzocht en of er een verschil is tussen homogene en heterogene paren.…
(more)
▼ Introductie In dit onderzoek is het verband tussen persoonlijkheid en conflict in broer/zus-relaties onderzocht en of er een verschil is tussen homogene en heterogene paren. Verwacht werd dat positieve persoonlijkheidskenmerken (vriendelijkheid, emotionele stabiliteit, zorgvuldigheid en openheid voor ideeën) zouden samenhangen met minder conflict. Meer negatieve of ambigue persoonlijkheidkenmerken (extraversie) zouden samenhangen met meer conflict. Methode Er hebben 886 brugklassers (N=427 jongens en N=459 meisjes), vragenlijsten ingevuld met vragen over hun persoonlijkheid (QBF) en over de mate van conflict (SRQ) in hun broer/zus-relaties. Resultaten De vijf persoonlijkheidskenmerken verklaarden samen 8,5% van het conflict in broer/zus-relaties. Tegen de verwachting in hing extraversie niet significant samen met conflict. Vriendelijkheid, zorgvuldigheid en emotionele stabiliteit bleken alle drie persoonlijkheidskenmerken die, volgens de verwachtingen, een negatief verband hadden met conflict. Tegen de verwachting in bleek openheid van ideeën positief samen te hangen met conflict. Om te onderzoeken of er een verschil is tussen homogene en heterogene broer/zus-paren zijn er interactie-effecten toegevoegd aan de regressieanalyse. Tegen de verwachting in werd het verband tussen persoonlijkheidskenmerken en conflict niet significant gemodereerd door seksecombinatie. Discussie Verschillende verklaringen worden gegeven voor het vinden van de resultaten. Voor een meer efficiënte preventie en begeleiding is deze kennis van deze voorspellers van conflict in de broer/zus-relatie van adolescenten van belang.
Advisors/Committee Members: Buist, K. L..
Subjects/Keywords: personality traits; Big Five; Conflict; gender combination
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APA (6th Edition):
Smit, B. C. M. (2016). Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/328809
Chicago Manual of Style (16th Edition):
Smit, B C M. “Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten.” 2016. Masters Thesis, Universiteit Utrecht. Accessed July 19, 2019.
http://dspace.library.uu.nl:8080/handle/1874/328809.
MLA Handbook (7th Edition):
Smit, B C M. “Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten.” 2016. Web. 19 Jul 2019.
Vancouver:
Smit BCM. Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten. [Internet] [Masters thesis]. Universiteit Utrecht; 2016. [cited 2019 Jul 19].
Available from: http://dspace.library.uu.nl:8080/handle/1874/328809.
Council of Science Editors:
Smit BCM. Persoonlijkheid en Conflict in Broer/Zus–Relaties van Adolescenten. [Masters Thesis]. Universiteit Utrecht; 2016. Available from: http://dspace.library.uu.nl:8080/handle/1874/328809
17.
趙, 茗.
Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義.
Degree: 博士（医学）, 2013, Kyushu University / 九州大学
URL: http://hdl.handle.net/2324/26344
;
http://dx.doi.org/10.15017/26344
► In this study, we examined the cytotoxic effects of combination therapy with zoledronic acid (ZOL) and gemcitabine (GEM) on pancreatic cancer cells in vitro and…
(more)
▼ In this study, we examined the cytotoxic effects of
combination therapy with zoledronic acid (ZOL) and gemcitabine (GEM) on pancreatic cancer cells in vitro and in vivo. Four human pancreatic cancer cell lines were treated with ZOL, GEM or a
combination of both, and the effects of the respective drug regimens on cell proliferation, invasion and matrix metalloproteinase (MMP) expression were examined. A pancreatic cancer cell line was also intrasplenically or orthotopically implanted into athymic mice and the effects of these drugs on tumor metastasis and growth in vivo were evaluated by histologic and immunohistochemical analyses.
Combination treatment with low doses of ZOL and GEM efficiently inhibited the proliferation (P < 0.001) and invasion (P < 0.001) of pancreatic cancer cells in vitro. Western blotting assay revealed that MMP-2 and MMP-9 expression levels were decreased after ZOL treatment. In vivo, combined treatment significantly inhibited tumor growth (P < 0.05) and the development of liver metastasis (P < 0.05). These data revealed that, when used in
combination, ZOL and GEM have significant antitumor, anti-metastatic and anti-angiogenic effects on pancreatic cancer cells. In the present study, we first reported the significance of the
combination treatment of ZOL and GEM in pancreatic cancer using an in vivo model. These data show promise for the future application of this drug regimen in patients with pancreatic cancer.
Advisors/Committee Members: 岩本, 幸英, 田中, 雅夫.
Subjects/Keywords: combination therapy; zoledronic acid; gemcitabine; pancreatic cancer
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APA (6th Edition):
趙, . (2013). Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義. (Thesis). Kyushu University / 九州大学. Retrieved from http://hdl.handle.net/2324/26344 ; http://dx.doi.org/10.15017/26344
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
趙, 茗. “Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義.” 2013. Thesis, Kyushu University / 九州大学. Accessed July 19, 2019.
http://hdl.handle.net/2324/26344 ; http://dx.doi.org/10.15017/26344.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
趙, 茗. “Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義.” 2013. Web. 19 Jul 2019.
Vancouver:
趙 . Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義. [Internet] [Thesis]. Kyushu University / 九州大学; 2013. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/2324/26344 ; http://dx.doi.org/10.15017/26344.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
趙 . Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer : 膵癌におけるゾレドロン酸及びゲムシタビン併用療法の意義. [Thesis]. Kyushu University / 九州大学; 2013. Available from: http://hdl.handle.net/2324/26344 ; http://dx.doi.org/10.15017/26344
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Kent State University
18.
Zhang, Huiying.
Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid.
Degree: MS, College of Arts and Sciences / Department of
Chemistry, 2010, Kent State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335
► Resveratrol, a naturally occurring polyphenol found in grapevines and other plants, has been shown to have anti-cancer, anti-viral, and other activities. The specific aim of…
(more)
▼ Resveratrol, a naturally occurring polyphenol found in
grapevines and other plants, has been shown to have anti-cancer,
anti-viral, and other activities. The specific aim of this thesis
research was to evaluate and compare the antitumor activities of
resveratrol alone and in
combination with ascorbate against a panel
of two human tumor cell lines (DU145 and MDAH) using a
micro-tetrazolium (MTT) assay. Triplicate samples were assayed 12,
24, 48, and 72 hours after continuous treatments, with twelve
concentrations of resveratrol and three or five
combination ratios
tested per time point. The FIC index, which is a marker of
synergism, was calculated. Results indicated that resveratrol and
ascorbate acted synergistically, reducing the time and
concentrations of each component necessary to achieve an effective
cytotoxicity level in hormone-independent cancer cell lines. The
systematic studies and analyses of resveratrol-ascorbate
combinations presented in this study have clinical significance for
the evaluation and development of
combination chemotherapy for the
treatment of various cancer diseases.
Advisors/Committee Members: Tsai, Chun-che (Committee Chair).
Subjects/Keywords: Biochemistry; Pharmaceuticals; Pharmacology; resveratrol; ascorbate; combination therapy
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Manager
APA (6th Edition):
Zhang, H. (2010). Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid. (Masters Thesis). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335
Chicago Manual of Style (16th Edition):
Zhang, Huiying. “Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid.” 2010. Masters Thesis, Kent State University. Accessed July 19, 2019.
http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335.
MLA Handbook (7th Edition):
Zhang, Huiying. “Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid.” 2010. Web. 19 Jul 2019.
Vancouver:
Zhang H. Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid. [Internet] [Masters thesis]. Kent State University; 2010. [cited 2019 Jul 19].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335.
Council of Science Editors:
Zhang H. Anticancer Activities of Resveratrol Alone and in
Combination with Ascorbic Acid. [Masters Thesis]. Kent State University; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335
University of Sydney
19.
Mohammad, Abdul Salam.
Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/16330
► Hypertension is a leading public health problem globally, particularly in low- and middle-income countries. The current approach to pharmacological management of hypertension has limitations and…
(more)
▼ Hypertension is a leading public health problem globally, particularly in low- and middle-income countries. The current approach to pharmacological management of hypertension has limitations and may contribute to poor hypertension control. A strategy of early use of lowdose combination therapy may improve outcomes but there is uncertainty about its potential effects.
Methods
Epidemiology of hypertension in India and Sri Lanka was described. Systematic reviews and meta-analyses were conducted to quantify the dose-related efficacy and safety of combination BP lowering drugs. Data from qualitative interviews of providers and patients were analysed to explore barriers to use of preventive drugs for CVD and acceptability of combination therapy as a solution to key barriers. Data from a large study in rural India were analysed to model the potential benefits of early use of low-dose triple combination therapy at a population level.
Results
The prevalence of uncontrolled hypertension among adults in India and Sri Lanka is currently estimated to be >70%. Meta-analyses of RCTs showed that compared to placebo, initial therapy with low-dose dual combination reduced BP by 10.1/5.9 mm Hg, whereas low-dose triple combination, tested as replacement therapy in only one trial, reduced BP by 17.9/9.8 mm Hg. Low-dose triple combination therapy vs. one std. dose monotherapy reduced BP by about 10/4 mm Hg. While there was no clear difference in tolerability between low-dose dual or triple combination therapies compared to placebo, data were sparse. From a patient and provider perspective, complex regimens and cost of drugs are major barriers to use of prescribed drugs. The use of combination therapy to simplify drug regimens and reduce cost was highly acceptable. The protocol for a new trial to address relevant evidence gaps is described. If the anticipated effects of this trial were applied at a population level the strategy of early use of low-dose combination therapy compared to the stepped care therapy can reduce BP by 7.8/3.5 mm Hg and improve BP control by 11%.
Conclusion
A strategy of early use of low-dose triple combination therapy has large potential to improve hypertension control safely and effectively, and is likely to be cost-effective whilst being acceptable to patients and providers. However, current data are insufficient and the ongoing TRIUMPH study will provide more definitive evidence.
Subjects/Keywords: blood pressure;
hypertension;
antihypertensive drugs;
combination therapy
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APA (6th Edition):
Mohammad, A. S. (2016). Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mohammad, Abdul Salam. “Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
.” 2016. Thesis, University of Sydney. Accessed July 19, 2019.
http://hdl.handle.net/2123/16330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mohammad, Abdul Salam. “Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
.” 2016. Web. 19 Jul 2019.
Vancouver:
Mohammad AS. Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/2123/16330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mohammad AS. Improving hypertension control with a strategy of early use of lowdose combination of blood pressure lowering drugs
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/16330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
20.
Alam, Md. Nur.
Studies on novel palladiums alone and in combination with phytochemicals in tumour models
.
Degree: 2018, University of Sydney
URL: http://hdl.handle.net/2123/18856
► Although platinum drugs cisplatin, carboplatin and oxaliplatin are routinely used in the clinic to treat various cancers including testicular, ovarian, head and neck, and colorectal…
(more)
▼ Although platinum drugs cisplatin, carboplatin and oxaliplatin are routinely used in the clinic to treat various cancers including testicular, ovarian, head and neck, and colorectal cancers, problems of drug resistance and side effects would limit their use. Thus thousands of cisplatin analogues have been prepared by changing nature of the leaving groups and carrier ligands with the aim of reducing the side effects and widening the spectrum of activity. It has been possible to reduce side effects by changing the nature of the leaving groups e.g. carboplatin that has bicarboxylate leaving group as against chloride in cisplatin is less toxic than cisplatin. Changing the carrier ligands has impacted activity to the compounds and types of cancer that is successfully targeted. For example, oxaliplatin which has DACH (1R, 2R)-(-)-1, 2-diaminecyclohexane) carrier ligand as against ammonia in cisplatin, is active against colorectal cancer while cisplatin and carboplatin are not. Substantial resemblance between chemistry of palladium (II) and platinum (II) has prompted studies of Pd(II) complexes as potential anticancer drugs.
Combining drugs with different modes of action can synergize their effects, where a combination therapy comprised of different mechanisms often provide distinct advantages over monotherapy. Much research is currently done on the combination of targeted therapy with phytochemicals. In this study, six novel palladium compounds (NH1, NH2, NH3, NH4, NH5 and NH6) have been synthesized using bulky planaramine ligands: quinoline, benzimidazole, 8-hydroxyquinoline and imidazo(1,2-α)pyridine. Moreover five tumour active phytochemicals: curcumin, EGCG, emetine, patulin and 6-shogaol have been combined with commonly used Pt based drugs as well as designed palladium compounds with the aim of providing a means of overcoming cisplatin resistance in ovarian and colorectal cancers.
All of the designed palladiums have been characterized by elemental microanalysis, IR spectroscopy, 1H-NMR spectroscopy, Mass spectroscopy. Moreover, three of the compounds (NH3, NH4 and NH6) have been characterized by single x-ray crystallography. Anticancer activity of the compounds were tested against eight different human cancer cell lines (ovarian cancer: A2780, A2780cisR and A2780ZDO473R; colorectal cancer: HT-29 and CACO-2; breast cancer: MCF-7; cervical cancer: Hela) by MTT reduction assay. NH3 has shown 10 to 96 times greater activity than cisplatin against all tested cell lines while NH1 has shown comparable activity. In binary combination with curcumin and EGCG, NH3 has shown sequence and concentration dependent synergism against ovarian and colorectal cancer models. 6-shogaol and curcumin in combination with NH1 have also shown synergism in many instances. Cisplatin in combination with emetine and patulin shows strong synergistic effect in A2780 and A2780cisR cell lines. Similarly oxaliplatin in combination with patulin has produced synergism in HT-29 cell line. DNA damage, cellular accumulation and metalDNA binding study…
Subjects/Keywords: Antieaneer;
Palladium drug;
Phytochemical;
Combination Study
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APA (6th Edition):
Alam, M. N. (2018). Studies on novel palladiums alone and in combination with phytochemicals in tumour models
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18856
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alam, Md Nur. “Studies on novel palladiums alone and in combination with phytochemicals in tumour models
.” 2018. Thesis, University of Sydney. Accessed July 19, 2019.
http://hdl.handle.net/2123/18856.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alam, Md Nur. “Studies on novel palladiums alone and in combination with phytochemicals in tumour models
.” 2018. Web. 19 Jul 2019.
Vancouver:
Alam MN. Studies on novel palladiums alone and in combination with phytochemicals in tumour models
. [Internet] [Thesis]. University of Sydney; 2018. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/2123/18856.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alam MN. Studies on novel palladiums alone and in combination with phytochemicals in tumour models
. [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/18856
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Rayes, Leila.
The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District.
Degree: Life Sciences, 2009, Södertörn University College
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2641
► The intention of the study is to evaluate the risk of artemisinin in early pregnancy through the use of a qualitative research approach, with…
(more)
▼ The intention of the study is to evaluate the risk of artemisinin in early pregnancy through the use of a qualitative research approach, with a focus on rural women in Babati District, Manyara Region, Tanzania. Artemisinin-Based Combination Therapy (ACT) is the most effective and recommended antimalarial treatment at the present. Artemisinin compounds are extracted from Artemisia annua, a plant which has been used as an herbal medical treatment in China for 2000 years. Except few side-effects, there have not been any reports on medical problems due to artemisinin intake during pregnancy. On the other hand, artemisinin tested on animals have revealed that complications such as death of embryos are possible during pregnancy, why more research is needed concerning artemisinin safety in first trimester of pregnancy. However, evaluating the risk of artemisinin in pregnancy is referred as complex, when numerous factors could contribute to e.g. fetal loss, abnormalities, or wrong medication. Cultural and economical aspects have to be considered when designing a monitoring system, to enable effective registration of drug quality and drug intake, and follow-up study of mother and child. Accessibility, affordability, possibility and knowledge, are other significant related aspects that have to be managed to eliminate the risk of artemisinin in early pregnancy.
Subjects/Keywords: malaria; combination therapy; traditional medicine; fetus
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Export
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APA (6th Edition):
Rayes, L. (2009). The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District. (Thesis). Södertörn University College. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rayes, Leila. “The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District.” 2009. Thesis, Södertörn University College. Accessed July 19, 2019.
http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rayes, Leila. “The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District.” 2009. Web. 19 Jul 2019.
Vancouver:
Rayes L. The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District. [Internet] [Thesis]. Södertörn University College; 2009. [cited 2019 Jul 19].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rayes L. The Risk of Artemisinin in Early Pregnancy : A Case-Study from Babati District. [Thesis]. Södertörn University College; 2009. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat de Valencia
22.
Deladriere, Coralie.
Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
.
Degree: 2013, Universitat de Valencia
URL: http://hdl.handle.net/10550/30243
► 1. Objetivos de la Investigación. Los conjugados poliméricos son nanoconstrucciones multicomponente presentes actualmente en clínica como terapia anticancerígena, tanto como agentes únicos, como formando parte…
(more)
▼ 1. Objetivos de la Investigación.
Los conjugados poliméricos son nanoconstrucciones multicomponente presentes actualmente en clínica como terapia anticancerígena, tanto como agentes únicos, como formando parte de combinaciones. Estos nanoconjugados tienen el potencial de mejorar farmacológicamente el tratamiento de tumores sólidos, debido a una acumulación pasiva en el tumor (efecto ‘EPR’) y a un diferente mecanismo de internalización celular y posterior liberación del fármaco(s). La transferencia de conjugados polímero-proteína a uso clínico rutinario, y el desarrollo clínico de conjugados polímero-fármaco anticancerígeno sitúa a los conjugados poliméricos como una de las primeras clases de nanomedicinas con potencial terapéutico antitumoral ya demostrado. La experiencia obtenida con los primeros nanoconjugados en clínica, ha proporcionado las bases para el desarrollo de polímeros conjugados más sofisticados de segunda generación con propiedades terapéuticas mejoradas. El desarrollo de nuevos portadores poliméricos biodegradables con propiedades mejoradas, la utilización de terapia de combinación o el diseño de conjugados dirigidos a nuevas dianas moleculares son algunas de las aproximaciones a seguir para conseguir conjugados más específicos y efectivos considerados de segunda generación. La propiedad de multivalencia que poseen los polímeros nos permite la conjugación de varios compuestos activos en el mismo esqueleto polimérico, la combinación del modulador activo con un citotóxico, otra sustancia activa o un residuo dirigente puede aumentar marcadamente el valor terapéutico de estas macromoléculas. En este sentido, el punto de partida de la presente propuesta es un nuevo concepto establecido por nosotros en 2005 con el desarrollo de HPMA copolimero-AGM-Dox, basado en la terapia de combinación (terapia endocrina + quimioterapia dentro de la misma matriz polimérica) para el tratamiento de cáncer de mama hormono-dependiente (Vicente et al., 2005). El valor terapéutico de esta nueva estrategia ha sido previamente demostrado en modelos celulares, lo que implicaría una clara aplicación potencial en el tratamiento de tumores hormono-dependientes en mujeres postmenopáusicas.
En el presente proyecto, se plantea corroborar la actividad antitumoral del nanoconjugado de combinación HPMA copolimero-AGM-Dox utilizando modelos in vivo, así como elucidar las bases moleculares responsables de su destacada actividad anticancerígena. La comprensión del mecanismo de acción molecular nos permitirá el diseño futuro de nanoconjugados de combinación con propiedades mejoradas. En una segunda etapa se propone mejorar el valor terapéutico de esta nueva terapia de combinación mediante la utilización de un polímero biodegradable como portador, ácido poli-L-glutámico (PGA), desarrollando un nuevo conjugado de combinación PGA-AGM-Dox y evaluando su actividad antitumoral en modelos in vitro e in vivo. La etapa final de la presente tesis doctoral consiste en el desarrollo de un cribado farmacológico utilizando 5 quimio agentes y 3 agentes de…
Advisors/Committee Members: Vicent Docón, María Jesús (advisor).
Subjects/Keywords: polymer therapeutics;
breast cancer;
combination therapy
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Deladriere, C. (2013). Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
. (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/30243
Chicago Manual of Style (16th Edition):
Deladriere, Coralie. “Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
.” 2013. Doctoral Dissertation, Universitat de Valencia. Accessed July 19, 2019.
http://hdl.handle.net/10550/30243.
MLA Handbook (7th Edition):
Deladriere, Coralie. “Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
.” 2013. Web. 19 Jul 2019.
Vancouver:
Deladriere C. Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
. [Internet] [Doctoral dissertation]. Universitat de Valencia; 2013. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/10550/30243.
Council of Science Editors:
Deladriere C. Polymer-drug conjugates as platforms for combination therapy in the treatment of hormone-dependent breast cancer
. [Doctoral Dissertation]. Universitat de Valencia; 2013. Available from: http://hdl.handle.net/10550/30243
University of Oregon
23.
Gibbs, Christopher.
Heterogeneous Expectations, Forecast Combination, and Economic Dynamics.
Degree: 2013, University of Oregon
URL: http://hdl.handle.net/1794/13279
► This dissertation examines the forecast model selection problem in economics in both theoretical and empirical settings. The forecast model selection problem is that there often…
(more)
▼ This dissertation examines the forecast model selection problem in economics in both theoretical and empirical settings. The forecast model selection problem is that there often exists a menu of different suitable models to forecast the same economic variable of interest. The theoretical portion of this dissertation considers agents who face this problem in two distinct scenarios. The first scenario considers the case where agents possess a menu of different forecast techniques which includes rational expectations but where the selection of rational expectations is costly. The assumptions that are necessary to include rational expectations as a choice are characterized and the equilibrium dynamics of a model under the appropriate assumptions is studied and shown to exhibit chaotic dynamics. The second scenario considers agents who possess a menu of econometric forecast models and examines the equilibrium outcomes when agents combine the different forecasts using strategies suggested by the forecasting literature. The equilibrium outcomes under these forecasting assumptions are shown to exhibit time-varying volatility and endogenous structural breaks, which are common features of macroeconomic data.
The empirical portion of the dissertation proposes a new dynamic
combination strategy for the forecast model selection problem to forecast inflation. The procedure builds on recent research on inflation persistence in the U.S. and on explanations for the efficacy of simple
combination strategies, often referred to as the forecast
combination puzzle. The new
combination strategy is shown to forecast well in real-time out-of-sample forecasting exercises.
Advisors/Committee Members: Evans, George (advisor).
Subjects/Keywords: Expectations; Forecast combination; Heterogeneous agents; Learning
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APA (6th Edition):
Gibbs, C. (2013). Heterogeneous Expectations, Forecast Combination, and Economic Dynamics. (Thesis). University of Oregon. Retrieved from http://hdl.handle.net/1794/13279
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gibbs, Christopher. “Heterogeneous Expectations, Forecast Combination, and Economic Dynamics.” 2013. Thesis, University of Oregon. Accessed July 19, 2019.
http://hdl.handle.net/1794/13279.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gibbs, Christopher. “Heterogeneous Expectations, Forecast Combination, and Economic Dynamics.” 2013. Web. 19 Jul 2019.
Vancouver:
Gibbs C. Heterogeneous Expectations, Forecast Combination, and Economic Dynamics. [Internet] [Thesis]. University of Oregon; 2013. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/1794/13279.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gibbs C. Heterogeneous Expectations, Forecast Combination, and Economic Dynamics. [Thesis]. University of Oregon; 2013. Available from: http://hdl.handle.net/1794/13279
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Columbia University
24.
Jacunski, Alexandra.
Using interspecies biological networks to guide drug therapy.
Degree: 2017, Columbia University
URL: https://doi.org/10.7916/D85149JB
► The use of drug combinations (DCs) in cancer therapy can prevent the development of drug resistance and decrease the severity and number of side effects.…
(more)
▼ The use of drug combinations (DCs) in cancer therapy can prevent the development of drug resistance and decrease the severity and number of side effects. Synthetic lethality (SL), a genetic interaction wherein two nonessential genes cause cell death when knocked out simultaneously, has been suggested as a method of identifying novel DCs. A combination of two drugs that mimic genetic knockout may cause cellular death through a synthetic lethal pathway. Because SL can be context-specific, it may be possible to find DCs that target SL pairs in tumours while leaving healthy cells unscathed.
However, elucidating all synthetic lethal pairs in humans would take more than 200 million experiments in a single biological context – an unmanageably large search space. It is thus necessary to develop computational methods to predict human SL.
In this thesis, we develop connectivity homology, a novel measure of network similarity that allows for the comparison of interspecies protein-protein interaction networks. We then use this principle to develop Species-INdependent TRAnslation (SINaTRA), an algorithm that allows us to predict SL between species using protein-protein interaction networks. We validate it by predicting SL in S. pombe from S. cerevisiae, then generate over 100 million SINaTRA scores for putative human SL pairs. We use these data to predict new areas of cancer combination therapy, and then test fifteen of these predictions across several cell lines. Finally, in order to better understand synergy, we develop DAVISS (Data-driven Assessment of Variability In Synergy Scores), a novel way to statistically evaluate the significance of a drug interaction.
Subjects/Keywords: Bioinformatics; Combination drug therapy; Drug interactions
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APA (6th Edition):
Jacunski, A. (2017). Using interspecies biological networks to guide drug therapy. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D85149JB
Chicago Manual of Style (16th Edition):
Jacunski, Alexandra. “Using interspecies biological networks to guide drug therapy.” 2017. Doctoral Dissertation, Columbia University. Accessed July 19, 2019.
https://doi.org/10.7916/D85149JB.
MLA Handbook (7th Edition):
Jacunski, Alexandra. “Using interspecies biological networks to guide drug therapy.” 2017. Web. 19 Jul 2019.
Vancouver:
Jacunski A. Using interspecies biological networks to guide drug therapy. [Internet] [Doctoral dissertation]. Columbia University; 2017. [cited 2019 Jul 19].
Available from: https://doi.org/10.7916/D85149JB.
Council of Science Editors:
Jacunski A. Using interspecies biological networks to guide drug therapy. [Doctoral Dissertation]. Columbia University; 2017. Available from: https://doi.org/10.7916/D85149JB
University of New South Wales
25.
Ehteda, Anahid.
Improving the anti-tumour efficacy of Albendazole.
Degree: Clinical School - St George Hospital, 2011, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/51821
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10488/SOURCE02?view=true
► Albendazole (ABZ) is a benzamidazole derivative that binds to β-tubulin and inhibits the polymerisation of microtubules. ABZ has a remarkable activity against a variety of…
(more)
▼ Albendazole (ABZ) is a benzamidazole derivative that binds to β-tubulin and inhibits the polymerisation of microtubules. ABZ has a remarkable activity against a variety of tumour cell lines including colorectal, liver, and ovarian cancer cells. In pre-clinical models, ABZ has been shown to have both anti-tumour and anti-angiogenic activities. Nevertheless, poor aqueous solubility of ABZ limits its absorption, and as a result, its efficacy. Therefore, the first aim of this project was to improve the aqueous solubility of ABZ. Using a combination of ionisation with acid and complexation with hydroxypropyl-β-cyclodextrin (HPβCD), a relatively high concentration of ABZ in solution was achieved. Comparison of pharmacokinetic profiles of ABZ/HPβCD with a conventional formulation of ABZ in hydroxypropyl methylcellulose (ABZ/HPMC) in nude mice revealed that complexation with HPβCD results in a significantly higher peak plasma concentration (Cmax) and area under the curve (AUC) of ABZ and its metabolites. Moreover, in mice-bearing human colorectal cancer cells, HCT-116, ABZ/HPβCD treatment led to a significant delay in tumour growth with increase in survival of animals as compared with vehicle and ABZ/HPMC treatments.The second aim of this research was to improve the efficacy of ABZ using combination therapy. To this end, the interaction between ABZ and different chemotherapeutic agents were assessed using the Sulforhodamine B assay (SRB) and quantified by median effect analysis method. Among the tested agents, a synergistic anti-proliferative effect was observed with the combination of ABZ and 2-methoxyestradiol (2ME) in HCT-116 and DU145. Of interest, 2ME, a microtubule targeting agent binds to similar colchicine-binding site of β-tubulin as ABZ and inhibits microtubules polymerisation. Synergistic interaction of ABZ and 2ME was accompanied with the activation of extrinsic pathway of apoptosis.In vivo, the combination of low concentration of ABZ with 2ME resulted in an increase in the survival rate of mice-bearing HCT-116 tumours. This effect was accompanied by a decrease in plasma and tumour vascular endothelial growth factor (VEGF) as well as a reduction in microvessel density. In addition, combination therapy led to a significant decrease in proliferation rate of the tumour and an increase in apoptosis. Noticeably, high concentration of ABZ, in combination with 2ME, resulted in an antagonistic effect on tumour growth and survival of the animals. Taken together, the solubility and anti-tumour efficacy of ABZ was highly increased by complexation with HPβCD, leading to the conclusion that the formulation may be suitable for parenteral administration. Moreover, combination of ABZ and 2ME has shown promising results in pre-clinical model. Additionally, the finding that the combination of two microtubule-binding agents that share the same binding site can act synergistically in vitro and in vivo may lead to the development of new therapeutic strategies in cancer treatment.
Subjects/Keywords: Combination Therapy; Albendazole; Formulation; 2-Methoxyestradiol
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APA (6th Edition):
Ehteda, A. (2011). Improving the anti-tumour efficacy of Albendazole. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51821 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10488/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Ehteda, Anahid. “Improving the anti-tumour efficacy of Albendazole.” 2011. Doctoral Dissertation, University of New South Wales. Accessed July 19, 2019.
http://handle.unsw.edu.au/1959.4/51821 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10488/SOURCE02?view=true.
MLA Handbook (7th Edition):
Ehteda, Anahid. “Improving the anti-tumour efficacy of Albendazole.” 2011. Web. 19 Jul 2019.
Vancouver:
Ehteda A. Improving the anti-tumour efficacy of Albendazole. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2019 Jul 19].
Available from: http://handle.unsw.edu.au/1959.4/51821 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10488/SOURCE02?view=true.
Council of Science Editors:
Ehteda A. Improving the anti-tumour efficacy of Albendazole. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51821 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10488/SOURCE02?view=true
University of Windsor
26.
McAuley, Tara.
Examining Semantic Effects in Conceptual Combination.
Degree: MA, Psychology, 2018, University of Windsor
URL: https://scholar.uwindsor.ca/etd/7542
► Conceptual combination is a cognitive process that produces complex concepts (e.g., adjective-noun pairs) from simple concepts. The Selective Modification Model (SMM; Smith, Osherson, Rips, &…
(more)
▼ Conceptual
combination is a cognitive process that produces complex concepts (e.g., adjective-noun pairs) from simple concepts. The Selective Modification Model (SMM; Smith, Osherson, Rips, & Keane, 1988) postulates that simple adjective-noun combinations (e.g., red apple) are understood by the modifier red selecting the colour attribute of the head noun apple. Theories of conceptual
combination have not extended to fulfill our understanding of how complex adjective-noun pairs (e.g., empty dream) are processed. This exploratory study had two main objectives: to determine which semantic variables best captured the processing of complex adjective-noun pairs and to examine the semantic effects of conceptual
combination to extend current theories. Adjective-noun combinations were manipulated based on subjective ratings (i.e., concreteness and plausibility; see the preliminary study) or objective measures (i.e., age of acquisition and semantic distance) and compared. Two hundred and ninety-three participants were randomly assigned to complete one of three computerized tasks that differentially engaged semantic processing from shallow to deep, including the non-pronounceable double lexical decision task (Experiment 1), the pronounceable double lexical decision task (Experiment 2), and the meaningfulness task (Experiment 3). Across all tasks, the subjective model outperformed the objective model in reaction time and accuracy analyses. Adjective-noun processing was facilitated by concrete, early acquired head nouns, as well as adjective-noun pairs that were rated as plausible and situated close in semantic space. Interestingly, adjectives paired with abstract head nouns were difficult to process across tasks regardless of how plausible the pair was. In conclusion, semantic variables rated by participants are valuable and may better capture how the mental lexicon is organized and accessed, and further research should pursue innovative ways of examining how abstract head nouns are processed to incorporate into existing theories.
Advisors/Committee Members: Buchanan, Lori.
Subjects/Keywords: conceptual combination; language comprehension; semantic effects
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APA (6th Edition):
McAuley, T. (2018). Examining Semantic Effects in Conceptual Combination. (Masters Thesis). University of Windsor. Retrieved from https://scholar.uwindsor.ca/etd/7542
Chicago Manual of Style (16th Edition):
McAuley, Tara. “Examining Semantic Effects in Conceptual Combination.” 2018. Masters Thesis, University of Windsor. Accessed July 19, 2019.
https://scholar.uwindsor.ca/etd/7542.
MLA Handbook (7th Edition):
McAuley, Tara. “Examining Semantic Effects in Conceptual Combination.” 2018. Web. 19 Jul 2019.
Vancouver:
McAuley T. Examining Semantic Effects in Conceptual Combination. [Internet] [Masters thesis]. University of Windsor; 2018. [cited 2019 Jul 19].
Available from: https://scholar.uwindsor.ca/etd/7542.
Council of Science Editors:
McAuley T. Examining Semantic Effects in Conceptual Combination. [Masters Thesis]. University of Windsor; 2018. Available from: https://scholar.uwindsor.ca/etd/7542
University of Minnesota
27.
Wei, Xiaoqiao.
Robust combinations of statistical procedures.
Degree: PhD, Statistics, 2010, University of Minnesota
URL: http://purl.umn.edu/101344
► Alternative to model selection, model combination gives a combined result from the individual candidate models to share their strengths. Yang (2001, 2004) proposed square-loss-based combining…
(more)
▼ Alternative to model selection, model combination gives a combined result from the individual candidate models to share their strengths. Yang (2001, 2004) proposed square-loss-based combining methods for regression analysis and forecast combinations. In this work, we propose robust combinations of statistical procedures. The theoretical properties of the robust combination methods are obtained, which show that the combined procedure automatically performs as well as the best one among the candidate models in estimation or prediction. Systematic simulations and data examples show that the robust methods outperform the square-loss-based combining methods when outliers are likely to occur and perform similarly to them when there are no outliers.
Subjects/Keywords: Model combination; Model selection; Robust combinations; Statistics
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APA (6th Edition):
Wei, X. (2010). Robust combinations of statistical procedures. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/101344
Chicago Manual of Style (16th Edition):
Wei, Xiaoqiao. “Robust combinations of statistical procedures.” 2010. Doctoral Dissertation, University of Minnesota. Accessed July 19, 2019.
http://purl.umn.edu/101344.
MLA Handbook (7th Edition):
Wei, Xiaoqiao. “Robust combinations of statistical procedures.” 2010. Web. 19 Jul 2019.
Vancouver:
Wei X. Robust combinations of statistical procedures. [Internet] [Doctoral dissertation]. University of Minnesota; 2010. [cited 2019 Jul 19].
Available from: http://purl.umn.edu/101344.
Council of Science Editors:
Wei X. Robust combinations of statistical procedures. [Doctoral Dissertation]. University of Minnesota; 2010. Available from: http://purl.umn.edu/101344
University of Newcastle
28.
Davey, Ryan James.
Examining the expression of nucleotide excision repair genes in melanoma tumours.
Degree: PhD, 2017, University of Newcastle
URL: http://hdl.handle.net/1959.13/1337722
► Research Doctorate - Doctor of Philosophy (PhD)
Melanoma is an aggressive form of cancer characterised by poor prognosis and resistance to treatment. Despite recent advances…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Melanoma is an aggressive form of cancer characterised by poor prognosis and resistance to treatment. Despite recent advances in melanoma treatment, patient outcomes continue to be underwhelming. After these new therapies showed initial promise; resistance and poor duration of response have limited their effectiveness as monotherapies. We are currently at the forefront of a wave of research into the underlying mechanisms of melanoma characteristics. It is now understood that for effective treatments to be developed, we must have a greater understanding of the genetic mechanisms of melanoma’s treatment resistance and abnormally aggressive phenotype. Ultraviolet radiation (UVR) has continually been intrinsically linked to melanoma development. In addition to this, resistance to traditional DNA-damaging chemotherapy drugs such as cisplatin remains a hallmark of melanoma cells. Nucleotide excision repair (NER) orchestrates the repair of helix distorting DNA damage, induced by both ultraviolet radiation (UVR) and cisplatin. There is evidence that the global genome repair (GGR) arm of NER is dysfunctional in melanoma and it is known to have limited induction in melanoma cell lines after cisplatin treatment. To further investigate the links between NER and melanoma, we examined the expression of multiple key genes involved in the NER pathway function and regulation, in a cohort of melanoma tumours. The expression of these transcripts was then compared to clinical parameters. In addition to this, expression of GGR damage recognition protein, XPC, was also quantified in melanoma tumours.
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Science and Pharmacy.
Subjects/Keywords: melanoma; treatment; targeted therapy; immunotherapy; combination therapy
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APA (6th Edition):
Davey, R. J. (2017). Examining the expression of nucleotide excision repair genes in melanoma tumours. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1337722
Chicago Manual of Style (16th Edition):
Davey, Ryan James. “Examining the expression of nucleotide excision repair genes in melanoma tumours.” 2017. Doctoral Dissertation, University of Newcastle. Accessed July 19, 2019.
http://hdl.handle.net/1959.13/1337722.
MLA Handbook (7th Edition):
Davey, Ryan James. “Examining the expression of nucleotide excision repair genes in melanoma tumours.” 2017. Web. 19 Jul 2019.
Vancouver:
Davey RJ. Examining the expression of nucleotide excision repair genes in melanoma tumours. [Internet] [Doctoral dissertation]. University of Newcastle; 2017. [cited 2019 Jul 19].
Available from: http://hdl.handle.net/1959.13/1337722.
Council of Science Editors:
Davey RJ. Examining the expression of nucleotide excision repair genes in melanoma tumours. [Doctoral Dissertation]. University of Newcastle; 2017. Available from: http://hdl.handle.net/1959.13/1337722
Rochester Institute of Technology
29.
Aher, Sheetal.
Determining the optimal stockpile level for combination vaccines.
Degree: MS, Industrial and Systems Engineering, 2017, Rochester Institute of Technology
URL: https://scholarworks.rit.edu/theses/9613
► By 2015, vaccine shortages still remained one of the major problems around the globe, as described in the annual secretariat report of the Global…
(more)
▼ By 2015, vaccine shortages still remained one of the major problems around the globe, as described in the annual secretariat report of the Global Vaccine Action Plan (GVAP). Despite multiple initiatives to reduce vaccine shortages, supply interruptions are unexpected and unavoidable. To mitigate the risk of such interruptions, vaccine stockpiles have traditionally been the tool of choice. However, the models used to determine vaccine stockpile levels have only considered the use of monovalent vaccines, which provide protection against a single disease. This study aims to determine optimal stockpile levels for
combination vaccines, which provide protection against multiple diseases. First, through discrete event simulation, we explore the effect on antigen shortages while maintaining stockpiles of multiple vaccines from multiple suppliers with different reliability conditions. We consider policies that mimic those of a decision maker that can either use vaccines with the most or the least reliable supply to set up the safety stockpile. Second, we propose a stochastic tractable safety stock model that considers the availability of a pool of monovalent and
combination vaccines in the stockpile. Finally, we contrast the recommendations from the simulation with those from the stochastic safety stock model, and we analyze the effect of having a mix of
combination and monovalent vaccines to mitigate the shortage risks for any given antigen.
Advisors/Committee Members: Ruben Proano, Ehsan Rashedi.
Subjects/Keywords: Combination vaccines; Pediatric vaccines; Safety stock; Stockpiles
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APA (6th Edition):
Aher, S. (2017). Determining the optimal stockpile level for combination vaccines. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/9613
Chicago Manual of Style (16th Edition):
Aher, Sheetal. “Determining the optimal stockpile level for combination vaccines.” 2017. Masters Thesis, Rochester Institute of Technology. Accessed July 19, 2019.
https://scholarworks.rit.edu/theses/9613.
MLA Handbook (7th Edition):
Aher, Sheetal. “Determining the optimal stockpile level for combination vaccines.” 2017. Web. 19 Jul 2019.
Vancouver:
Aher S. Determining the optimal stockpile level for combination vaccines. [Internet] [Masters thesis]. Rochester Institute of Technology; 2017. [cited 2019 Jul 19].
Available from: https://scholarworks.rit.edu/theses/9613.
Council of Science Editors:
Aher S. Determining the optimal stockpile level for combination vaccines. [Masters Thesis]. Rochester Institute of Technology; 2017. Available from: https://scholarworks.rit.edu/theses/9613
University of North Texas
30.
Yan, Zhishan.
Shear and Compression Strength of Cold-formed Steel Clip Angles Subjected to Different Screw Patterns.
Degree: 2017, University of North Texas
URL: https://digital.library.unt.edu/ark:/67531/metadc1062892/
► This thesis presents experiments and numerical analysis of the cold-formed steel clip angle in three different limit states which are shear, compression, and combination of…
(more)
▼ This thesis presents experiments and numerical analysis of the cold-formed steel clip angle in three different limit states which are shear, compression, and
combination of the screw connection. A previous cold-formed steel clip angle test program (which is Phase 1) developed design methods for clip angle. Therefore, the object of this thesis is to further investigate the behavior and design methods of loading-bearing cold-formed steel clip angles under different screw pattern. For each limit state, a test program was conducted to investigate the behavior, strength, and deflection of the clip angle. The test result were compared with previous CFS clip angle design method. Amending existing CFS clip angle method were developed by each of the four limit states studied in this project.
Advisors/Committee Members: Yu, Cheng, Nasrazadani, Seifollah, Bostanci, Huseyin.
Subjects/Keywords: Clip angles; shear; compression; combination; strength
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◁ [1] [2] [3] [4] [5] … [24] ▶
. 
Open Access Theses and Dissertations
