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You searched for subject:(Clodronato). One record found.

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Universitat Autònoma de Barcelona

1. García Torralbo, Eva Mª. Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental.

Degree: Departament de Cirurgia, 2005, Universitat Autònoma de Barcelona

Study Objective: 1) To compare the bacterial translocation in a traumatic experimental model, between animals with or without macrophage elimination. 2) To study the systemic toxicity differences between animals with or without macrophage elimination. 3) To compare the mortality rates between the two groups. Design: Experimental study, prospective and randomized. Animals were introduced into a politraumatic machine to reproduce an experimental traumatism. The animals were randomized into two groups, with or without injection of dichloromethylene-diphosphonate-containing liposomes that produces macrophage elimination. Measurements: Testing for bacterial translocation to mesenteric lymph nodes, liver spleen and lung, systemic toxicity control and mortality. Key words: Traumatism. Multiple organ failure. Macrophage elimination. OBJECTIVE: The central question tested in this study was whether dichloromethylene-diphosphonate (CL2MDP) liposome-mediated elimination of hepatic and splenic macrophages would influence zymosan-induced bacterial translocation and the zymosan-induced generalized inflammatory response. SUMMARY BACKGROUND DATA: Both an uncontrolled activation of macrophages and the loss of intestinal barrier function have been implicated in the development of adult respiratory distress syndrome and multiple organ failure. METHODS: Macrophage elimination was accomplished by intravenous injection of 200 microL of CL2MDP-liposome suspension. Control mice received an intravenous injection of 200 microL of phosphate-buffered saline. Two days later, the animals were challenged intraperitoneally with zymosan suspended in paraffin to determine a dose-response curve (0.1, 0.5, or 1.0 mg/g body weight). Twenty-four hours after zymosan challenge, signs of systemic stress were determined, and bacterial translocation to the mesenteric lymph node, liver, spleen, and blood was measured. A separate mortality study was performed with a dose of 1.0 mg/g of zymosan suspension. RESULTS: The incidence of the systemic spread of bacteria was significantly increased in the macrophage-depleted mice. Although systemic bacterial translocation was promoted by macrophage elimination, the systemic toxic response was significantly decreased in all macrophage-depleted groups (p < or = 0.01). The 12-day mortality rate was 0% in the macrophage-depleted groups and 27% in the control group (p = 0.05). CONCLUSIONS: The lethal and toxic effects of zymosan appear to be related more to the excessive activation of macrophages than to the systemic spread of bacteria. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Sánchez Ortega, José Manuel (director), Navarro Soto, Salvador (director).

Subjects/Keywords: Clodronato; Fracaso multiorgánico; Traumatismo; Ciències de la Salut; 61

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APA (6th Edition):

García Torralbo, E. M. (2005). Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/4285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

García Torralbo, Eva Mª. “Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental.” 2005. Thesis, Universitat Autònoma de Barcelona. Accessed April 24, 2019. http://hdl.handle.net/10803/4285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

García Torralbo, Eva Mª. “Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental.” 2005. Web. 24 Apr 2019.

Vancouver:

García Torralbo EM. Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2005. [cited 2019 Apr 24]. Available from: http://hdl.handle.net/10803/4285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

García Torralbo EM. Modulación del Fracaso Multiorgánico mediante depleción macrofágica en un modelo de politraumatismo experimental. [Thesis]. Universitat Autònoma de Barcelona; 2005. Available from: http://hdl.handle.net/10803/4285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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