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Oregon State University
1.
Trenkel-Amoroso, Jan.
Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer.
Degree: MS, Materials Science, 2009, Oregon State University
URL: http://hdl.handle.net/1957/10193
► This study looks at the properties of glycerol/citric acid as they are affected by the length and temperature of the bake used to facilitate the…
(more)
▼ This study looks at the properties of glycerol/
citric acid as they are affected by the
length and temperature of the bake used to facilitate the condensation reaction that creates
the polymer. In particular, the length of time required for the polymer to break down in
the presence of water, both humidity and submersion, was examined. Given the degradable
nature of the glycerol/
citric acid it was examined for suitability as a replacement for
Bitusize (emulsified asphalt) in the making of degradable flower pots. It was found that the
Bitusize did not act as a binder in the flower pots, but as a water repellant, thus the
glycerol/
citric acid polymer was not a suitable replacement material.
Advisors/Committee Members: Rochefort, Willie E (Skip) (advisor), Hackleman, David (committee member).
Subjects/Keywords: Citric Acid; Citric acid
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APA (6th Edition):
Trenkel-Amoroso, J. (2009). Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/10193
Chicago Manual of Style (16th Edition):
Trenkel-Amoroso, Jan. “Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer.” 2009. Masters Thesis, Oregon State University. Accessed January 16, 2021.
http://hdl.handle.net/1957/10193.
MLA Handbook (7th Edition):
Trenkel-Amoroso, Jan. “Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer.” 2009. Web. 16 Jan 2021.
Vancouver:
Trenkel-Amoroso J. Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer. [Internet] [Masters thesis]. Oregon State University; 2009. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1957/10193.
Council of Science Editors:
Trenkel-Amoroso J. Synthesis, degradation and practical applications of a glycerol/citric acid condensation polymer. [Masters Thesis]. Oregon State University; 2009. Available from: http://hdl.handle.net/1957/10193

University of Adelaide
2.
Alkhaldi, Mohammed.
Reaction of citric acid with calcite.
Degree: 2010, University of Adelaide
URL: http://hdl.handle.net/2440/61968
► This study is the first one to examine the reaction of citric acid with calcite over a wide range of parameters. Its main focus is…
(more)
▼ This study is the first one to examine the reaction of
citric acid with calcite over a wide range of parameters. Its main focus is to study the effects of different parameters such as initial
citric acid concentration and temperature on the
citric-calcite reaction.
A rotating disk apparatus was used to study the reaction of calcite (CaC0₃) with
citric acid. Using the rotating disk theory, the calcite dissolution rates in
citric acid solutions were evaluated as a function of rotating speed, initial concentration of
citric acid, concentration of magnesium (Mg²⁺) & Iron (Fe³⁺) ions, temperature, and pressure. In addition, Scanning Electron Microscopy (SEM) technique was used to explore the precipitation mechanism of calcium citrate during the reaction of
citric acid with calcite. Using this technique, several factors affecting the precipitation of calcium citrate were identified.
In this research,
citric acid was found to be an effective stimulation fluid at pH values < 4, rotational speeds of (100-1,000 rpm), initial
citric acid concentration of 1-7.5 wt%, pressure values of 1,000-1,500 psi, and temperatures of 25-50 °C. However, SEM analysis has shown that calcium citrate precipitation occurred during the reaction at the calcite disk. The precipitation of calcium citrate was found be function of disk rotational speed, initial
citric acid concentration, and the concentration of both Mg²⁺ and Fe³⁺ ions. More calcium citrate precipitated at high rotational speeds and high initial
citric acid concentration. The presence of both Mg²⁺ and Fe³⁺ ions minimized the precipitation of calcium citrate.
The rate of calcite dissolution in
citric acid was found to be mainly dependent on the rotational speed. In general, at low rotational speeds, below 500 rpm, the calcite dissolution is mainly governed by the mass-transfer rate, while at high rotational speed, above 500 rpm, it is controlled by the surface-reaction rate. The mass-transfer and the surface-reaction mechanism were investigated thoroughly.
Using the rotating disk theory, the overall mass transfer coefficient was determined at various rotational speeds, initial
citric acid concentrations, and temperature values. The effective diffusion coefficient of
citric as was determined at various
citric acid concentrations and various temperature values. In addition, the apparent activation energy of calcite dissolution in mass-transfer regime was found to be 37.9 kJ/mol. Finally, a simplified expression was developed to model the reaction kinetics of
citric acid with calcite. The model parameters: reaction order, and activation energy were found to be 0.833 and 63.1 kJ/mol, respectively.
This study highlights the importance of the initial
acid concentration, temperature, and calcium citrate precipitation on the
citric acid reaction with calcite. Another important outcome is the effect of various key parameters on the performance of
citric acid as a stand-alone stimulation fluid at conditions similar to those present in a typical field case.
Findings based on this work…
Advisors/Committee Members: Australian School of Petroleum (school).
Subjects/Keywords: citric acid; calcite; Citric acid.; Calcite.
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Alkhaldi, M. (2010). Reaction of citric acid with calcite. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/61968
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alkhaldi, Mohammed. “Reaction of citric acid with calcite.” 2010. Thesis, University of Adelaide. Accessed January 16, 2021.
http://hdl.handle.net/2440/61968.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alkhaldi, Mohammed. “Reaction of citric acid with calcite.” 2010. Web. 16 Jan 2021.
Vancouver:
Alkhaldi M. Reaction of citric acid with calcite. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2440/61968.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alkhaldi M. Reaction of citric acid with calcite. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/61968
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University
3.
Andotra, Gautam.
Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes.
Degree: MS, Petroleum Engineering, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/153620
► Mud acid, a mixture of HCl and HF, has been frequently used for stimulating sandstone reservoirs. However, using HCl in such environments can be problematic,…
(more)
▼ Mud
acid, a mixture of HCl and HF, has been frequently used for stimulating sandstone reservoirs. However, using HCl in such environments can be problematic, especially at higher temperatures. Some of the most common problems are the following: clay sensitivity, secondary/tertiary reactions, and precipitation of salts and corrosion. To combat these problems mixtures of HF have been developed along with organic acids and chelating agents such as
citric acid, acetic
acid, EDTA, HEDTA, GLDA etc. Compared to HCl, these chelating agents offer lower corrosion, no mineral sensitivity issues, stability at high temperatures (˂ 200 °F) and bio-degradability.
This thesis explores the use of two chelating agents,
citric acid and a newly developed sodium salt of L-Glutamic
acid N,N-Di Acetic
Acid (Na-GLDA). Experiments were conducted to find out the aluminosilicates dissolution and chelation capabilities of these chelating agents. The first set of experiments were clay dissolution experiments, conducted using different concentrations of
citric acid (1 wt%, 3 wt%, and 5 wt%) added to regular 9:1 mud
acid. This was done to study and analyze its clay dissolution properties, as well as its chelation abilities to reduce precipitation. For comparison purposes, experiments were also completed using regular 9:1 mud
acid to compare its results to that of using
citric acid along with 9:1 mud
acid. The results suggest that using 1 wt%
citric acid along with 9:1 mud
acid provided the best results, both in terms of clay dissolution as well as reducing precipitate formation.
The next set of experiments investigated the use of Na-GLDA along with HF for sandstone acidizing purposes. First, compatibility experiments were conducted to find out the optimum
acid mixture between Na-GLDA and HF that causes no incompatibilities. Following the compatibility test, coreflood experiments were run on Bandera and Berea cores using the optimum
acid mixture formulation found in the preceding experiment. Coreflood results showed the good chelation ability of Na-GLDA to iron, calcium and magnesium. But very low concentrations of any aluminosilicates were found in the ICP samples indicating either the lack of dissolution of aluminosilicates or the precipitation of aluminosilicates within the core.
In conclusion, the experimental results suggest that adding 1 wt%
citric acid to 9:1 mud
acid provides better dissolution and precipitation results. But factoring in the cost of
citric acid makes it a financially unfavorable formulation, especially since regular 9:1 mud
acid performed almost as well as 9:1 mud
acid with 1 wt%
citric acid added to it. Also, the newly developed Na-GLDA is compatible with HF at certain concentrations of both. The optimum
acid mixture formulation was found to be 20 wt% Na-GLDA + 1 wt% HF. Coreflood results show that Na-GLDA added to HF is able to keep cations such as iron, calcium and magnesium in solution at higher temperatures, but it is unable to properly dissolve and chelate to aluminosilicates and its damaging salts.
Advisors/Committee Members: Nasr-El-Din, Hisham A (advisor), Lane, Robert H (advisor), El-Halwagi, Mahmoud (committee member).
Subjects/Keywords: Sandstone Acidizing; GLDA; Citric Acid
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Andotra, G. (2014). Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153620
Chicago Manual of Style (16th Edition):
Andotra, Gautam. “Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes.” 2014. Masters Thesis, Texas A&M University. Accessed January 16, 2021.
http://hdl.handle.net/1969.1/153620.
MLA Handbook (7th Edition):
Andotra, Gautam. “Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes.” 2014. Web. 16 Jan 2021.
Vancouver:
Andotra G. Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1969.1/153620.
Council of Science Editors:
Andotra G. Investigating the Use of Chelating Agents for Clay Dissolution and Sandstone Acidizing Purposes. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153620

University of Saskatchewan
4.
Mohanty, Sidhartha.
Effect of citric acid on hydrotreating activity of NiMo catalysts.
Degree: 2011, University of Saskatchewan
URL: http://hdl.handle.net/10388/ETD-2011-12-276
► With depleting reserves of sweet crude oil, there is an increasing demand world over to process heavy crudes. Canada’s Athabasca oil sands basin is a…
(more)
▼ With depleting reserves of sweet crude oil, there is an increasing demand world over to process heavy crudes. Canada’s Athabasca oil sands basin is a rich source of this heavy feedstock derived from bitumen. However, the heavy gas oil feedstock derived from this bitumen has very high quantities of S (4 wt %) and N (0.4 wt %). In order to meet today’s strict environmental regulations, design of hydrotreating catalysts with increased active site density and improved intrinsic catalytic activity per site is critical. This work, in the first phase deals with the modification of the Al2O3 support to increase its acidity and in subsequent phases,
citric acid has been used as an additive to enhance the formation of Type II NiMoS sites.
Mesostructured alumino-silicate (MAS) materials were synthesized from ZSM-5 nanoclusters and used as catalysts supports for the hydrotreatment of a model compound and real feed stock. The alumino-silicate materials exhibited different
acid strengths and textural properties depending on the duration of hydrothermal treatment of the zeolite seeds. The acidity of the MAS materials were found significantly higher than Al-SBA-15 and Al2O3 materials. The activity of NiMo catalysts supported on MAS materials were evaluated using the hydrodesulfurization of dibenzothiophene (DBT). The NiMo catalyst supported on mesoporous alumino silicate obtained after 16 hrs of hydrothermal treatment of the ZSM-5 precursors was found to be the most active in the HDS of DBT. Similarly, hydrotreating tests revealed that the composite made of 5 wt % MAS-16 and 95 wt % γ-Al2O3 was best suited for hydrotreating reactions with real feedstock. This support showed optimum acidity and excellent dispersion of the active species and was selected as the support of choice for all further hydrotreating reactions with real feed stock.
In the second stage of this work
citric acid (CA) in varying ratios was used to prepare NiMo catalysts supported on a composite of γ-Al2O3 and mesoporous alumino-silicates.
Citric acid was found to form a complex with both Ni and Mo simultaneously. However, the promoting effect of
citric acid in the hydrotreating was observed mostly due to the formation of a stable nickel-citrate complex. The hydrotreating activity of the synthesized catalysts is evaluated using heavy gas oil (HGO) derived from Athabasca bitumen, in a trickle bed continuous reactor. The Mo loading, Ni loading and the
citric acid to nickel molar ratios were optimized on the basis of hydrodesulfurization (HDS) and hydrodenitrogenation (HDN) activity of HGO. The best performing catalyst for the hydrotreating of heavy gas oil was obtained for a Mo loading of 13 wt %, Ni loading of 7 wt % and CA/Ni molar ratio of 1. The sulfur and nitrogen conversions for the best catalyst were found to be 93 wt % and 74 wt % respectively.
Advisors/Committee Members: Dalai, Ajay, Adjaye, John, Hu, Yongfeng, Wang, Hui, Urquhart, Stephen.
Subjects/Keywords: Hydrotreating; Citric acid; XAS; NiMoS
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mohanty, S. (2011). Effect of citric acid on hydrotreating activity of NiMo catalysts. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2011-12-276
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mohanty, Sidhartha. “Effect of citric acid on hydrotreating activity of NiMo catalysts.” 2011. Thesis, University of Saskatchewan. Accessed January 16, 2021.
http://hdl.handle.net/10388/ETD-2011-12-276.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mohanty, Sidhartha. “Effect of citric acid on hydrotreating activity of NiMo catalysts.” 2011. Web. 16 Jan 2021.
Vancouver:
Mohanty S. Effect of citric acid on hydrotreating activity of NiMo catalysts. [Internet] [Thesis]. University of Saskatchewan; 2011. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10388/ETD-2011-12-276.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mohanty S. Effect of citric acid on hydrotreating activity of NiMo catalysts. [Thesis]. University of Saskatchewan; 2011. Available from: http://hdl.handle.net/10388/ETD-2011-12-276
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University
5.
Dawson, Mark William.
A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger.
Degree: PhD, Biotechnology, 1986, Massey University
URL: http://hdl.handle.net/10179/2307
► The aim of this work was to obtain detailed information on the production of citric acid during submerged fermentation by Aspergillus niger, in an attempt…
(more)
▼ The aim of this work was to obtain detailed information on the production of citric acid during submerged fermentation by Aspergillus niger, in an attempt to understand and optimize the process. Initial experiments were performed to determine the effect of interruptions to aeration on citric acid production. Unless the value of the Dissolved Oxygen Tension (DOT) of the culture fell below the DOT crit. (20% of saturation), no gross effect was observed. When the DOT value fell to zero, citric acid production ceased. Production however, recovered after recommencement of aeration, albeit after a delay. Experiments were performed in batch fermentation using various non-carbohydrate medium components as the growth-limiting nutrient. Nitrogen-, phosphate- or sulphate-limited cultures resulted in strong citric acid production. The most significant observation during these fermentations was that the maximum citric acid production rate occurred prior to the exhaustion of the limiting nutrient, i.e. when the organism was at a positive growth rate. Chemostat experiments were performed in order to determine the effect of the growth rate and the culture DOT on citric acid production. Maximum citric acid production rates and yields were achieved at low growth rate (u = 0.017 h-1 ) and high DOT (90% of saturation) values. The specific citric acid production rate was twice the maximum observed in batch fermentation, and the product yield was increased by 23%. The information regarding growth rate and DOT gained from the chemostat experiments was applied to a continuous fed-batch fermentation using nitrogen as the growth-limiting nutrient. The overall fermenter productivity attained was double that of the batch fermentation, resulting in a halving of the fermentation period. This is the first reported use of the continuous fed-batch technique for citric acid production. In all three fermentation modes (batch, chemostat and fed-batch), nitrogen limitation was superior to phosphate limitation in terms of citric acid production rates and yields. A double nitrogen/phosphate limitation gave results almost identical to a nitrogen limitation. The evidence suggests that the nitrogen nutrient exerts a form of catabolite repression on citric acid accumulation.
Subjects/Keywords: Citric acid
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dawson, M. W. (1986). A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/2307
Chicago Manual of Style (16th Edition):
Dawson, Mark William. “A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger.” 1986. Doctoral Dissertation, Massey University. Accessed January 16, 2021.
http://hdl.handle.net/10179/2307.
MLA Handbook (7th Edition):
Dawson, Mark William. “A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger.” 1986. Web. 16 Jan 2021.
Vancouver:
Dawson MW. A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger. [Internet] [Doctoral dissertation]. Massey University; 1986. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10179/2307.
Council of Science Editors:
Dawson MW. A study of citric acid production by submerged aerobic fermentation using the fungus Aspergillus niger. [Doctoral Dissertation]. Massey University; 1986. Available from: http://hdl.handle.net/10179/2307

University of Manchester
6.
Elshukri, Omsaad.
The effects of carbonated fluids on the human cortical swallowing motor system.
Degree: Thesis (M.D.), 2013, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-carbonated-fluids-on-the-human-cortical-swallowing-motor-system(770f0e3e-795c-4e5c-b1d0-8a8ae1ba06bb).html
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574296
► Swallowing is a complex neurophysiological process involving the activation of several components of the central nervous system with bilateral but asymmetric representations of swallowing musculature…
(more)
▼ Swallowing is a complex neurophysiological process involving the activation of several components of the central nervous system with bilateral but asymmetric representations of swallowing musculature in the motor cortex. Difficulty in swallowing (dysphagia) in stroke patients has been reported by up to 50% of victims, and can increase morbidity and mortality in this population due to the development of aspiration pneumonia and malnutrition. One of the common factors that predispose patients to dysphagia after a stroke is believed to be the reduced sensory awareness in the oropharyngeal area, which affects the swallowing process. The uses of diet modification to reduce thin liquid aspiration have gained interest but are often unpalatable or have limited success. Carbonated liquid have shown some beneficial effects in swallowing behaviour. However, there is very little evidence to support this intervention. Therefore, the aim of this thesis is to investigate the neurophysiological and behavioural effects of carbonated liquids on swallowing in healthy volunteers.The effects of carbonated solutions on swallowing performance compared to non-carbonated solutions (still water) was investigated in a pilot study and (still water and citric acid) in the main study using reaction time task (chapter 2). Carbonation appears to alter swallowing performance compared to other liquids by improving complex tasks. In addition, beneficial neurophysiological effects of carbonated liquids were evident after 10 minutes of carbonated liquid swallowing compared to still water and citric acid solution in healthy volunteers (chapter 3).In chapter 4, the response of the healthy swallowing motor cortex to carbonated liquids following application of a virtual lesion compared to still water and saliva swallowing, was investigated. Carbonated liquids were able to reverse the inhibitory effect induced by 1 Hz rTMS to the dominant pharyngeal motor representation. Moreover, the beneficial effects of carbonated liquids on swallowing performance, measured with a swallowing reaction times task after application of a virtual lesion was observed in a pilot investigation in healthy volunteers (chapter 5). These data demonstrate that carbonated liquids have beneficial neurophysiological and swallowing performance effects and support notion that the chemical properties of carbonated liquids may provide the required peripheral sensory information that alter the brain swallowing function, which leads to an improvement in the swallowing performance of stroke dysphagic patients. These data lay the foundation for considering the use of carbonation as facilitating stimuli in dysphagic patients.
Subjects/Keywords: 616.323; Carbonated; Citric acid; TMS; rTMS
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Elshukri, O. (2013). The effects of carbonated fluids on the human cortical swallowing motor system. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-carbonated-fluids-on-the-human-cortical-swallowing-motor-system(770f0e3e-795c-4e5c-b1d0-8a8ae1ba06bb).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574296
Chicago Manual of Style (16th Edition):
Elshukri, Omsaad. “The effects of carbonated fluids on the human cortical swallowing motor system.” 2013. Doctoral Dissertation, University of Manchester. Accessed January 16, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-carbonated-fluids-on-the-human-cortical-swallowing-motor-system(770f0e3e-795c-4e5c-b1d0-8a8ae1ba06bb).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574296.
MLA Handbook (7th Edition):
Elshukri, Omsaad. “The effects of carbonated fluids on the human cortical swallowing motor system.” 2013. Web. 16 Jan 2021.
Vancouver:
Elshukri O. The effects of carbonated fluids on the human cortical swallowing motor system. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Jan 16].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-carbonated-fluids-on-the-human-cortical-swallowing-motor-system(770f0e3e-795c-4e5c-b1d0-8a8ae1ba06bb).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574296.
Council of Science Editors:
Elshukri O. The effects of carbonated fluids on the human cortical swallowing motor system. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-effects-of-carbonated-fluids-on-the-human-cortical-swallowing-motor-system(770f0e3e-795c-4e5c-b1d0-8a8ae1ba06bb).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574296

Michigan State University
7.
Tishel, Moshe.
Accumulation of citric acid in fruit.
Degree: PhD, Department of Food Science, 1967, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:24963
Subjects/Keywords: Citric acid; Fruit
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tishel, M. (1967). Accumulation of citric acid in fruit. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:24963
Chicago Manual of Style (16th Edition):
Tishel, Moshe. “Accumulation of citric acid in fruit.” 1967. Doctoral Dissertation, Michigan State University. Accessed January 16, 2021.
http://etd.lib.msu.edu/islandora/object/etd:24963.
MLA Handbook (7th Edition):
Tishel, Moshe. “Accumulation of citric acid in fruit.” 1967. Web. 16 Jan 2021.
Vancouver:
Tishel M. Accumulation of citric acid in fruit. [Internet] [Doctoral dissertation]. Michigan State University; 1967. [cited 2021 Jan 16].
Available from: http://etd.lib.msu.edu/islandora/object/etd:24963.
Council of Science Editors:
Tishel M. Accumulation of citric acid in fruit. [Doctoral Dissertation]. Michigan State University; 1967. Available from: http://etd.lib.msu.edu/islandora/object/etd:24963

The Ohio State University
8.
Chi, Yuan.
The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films.
Degree: MS, Food Science and Technology, 2019, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1563494987482215
► This study investigated the impact of selected treatments on crosslinking in starch edible films. The treatment investigated were citric acid as the crosslinking agent, glycerol…
(more)
▼ This study investigated the impact of selected
treatments on crosslinking in starch edible films. The treatment
investigated were
citric acid as the crosslinking agent, glycerol
as a plasticizer, and the pH of the film-forming solution. To
determine the influence of these treatments on the films, the
thermal, mechanical, and morphological properties were measured and
compared with native starch as a control. The first section
(Chapter 2) of this study focused on the effect of
citric acid
concentrations on the properties of the films. For this analysis,
aqueous film-forming solutions containing 5% tapioca starch, 2.2%
glycerol and 0, 1, 3, 5, 7 and 9 % (w/w of tapioca)
citric acid
were prepared. These were gelatinized and cast into Teflon plates
and dried at 45 °C for 12 hours. To understand the nature of the
crosslinking that formed between the starch polymeric chains, an
Attenuated Total Reflection Fourier Transformation Infrared
Spectroscopy (ATR-FTIR) analysis was performed on all samples. To
understand the impact of the treatments on the morphology of the
films, the crystallinity of the samples was analyzed by X-Ray
Diffraction (XRD). A thermal gravimetric analysis (TGA) was used to
investigate the behavior of the films to temperatures ranging from
25 to 600 °C.To correlate the influence of the treatments on the
mechanical properties of the film samples, the tensile profile
analysis (TPA) provided an opportunity to measure the tensile
strength, percent elongation and modulus of elasticity of the films
exposed to the various treatments. In the second section (Chapter
3) the influence of the plasticizer concentration on the film
properties is reported. The edible films were formed by dissolving
5% tapioca starch, 3%
citric acid (w/w of tapioca), and 2.1, 2.3,
2.5, 2.7 and 2.9% glycerol into a film-forming solution. The films
were formed as described above. The film properties were analyzed
by the same methods described in the paragraph above. In the third
section (Chapter 4) the influence of different levels of pH’s the
properties of the films was investigated. The edibles films were
formed by dissolving 5% tapioca, 2.2% glycerol and 3%
citric acid
(w/w of tapioca) at pH levels of 3, 5, 7, 9 and 11. The films were
formed as described above. The film properties were analyzed by the
same methods described in the paragraph above. The FTIR results
indicated that the crosslinking was facilitated by ester linkages
at peak location of 1520 cm-1. It also showed that the degree of
crosslinking was be optimized by 9%
citric acid, 2.5 % glycerol,
and at a pH level of 7. The XRD results showed that 3% critic
acid,
2.3% glycerol, and pH 3 provided the starch with the lowest
crystallinity. The 9%
citric acid, 2.9% glycerol, and pH 11provided
the cornstarch with the highest level of crystallinity. The TGA
results showed that in general, the physical decomposition
temperatures of the crosslinked starch films were lower than that
of the native starch film, while the thermal stability of
crosslinked starches was higher than the native…
Advisors/Committee Members: Pascall, Melvin (Advisor).
Subjects/Keywords: Food Science; Crosslink, starch, citric acid, glycerol
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Chicago ·
MLA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Chi, Y. (2019). The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1563494987482215
Chicago Manual of Style (16th Edition):
Chi, Yuan. “The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films.” 2019. Masters Thesis, The Ohio State University. Accessed January 16, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1563494987482215.
MLA Handbook (7th Edition):
Chi, Yuan. “The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films.” 2019. Web. 16 Jan 2021.
Vancouver:
Chi Y. The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films. [Internet] [Masters thesis]. The Ohio State University; 2019. [cited 2021 Jan 16].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1563494987482215.
Council of Science Editors:
Chi Y. The Influence of Citric Acid, Glycerol and pH on
Crosslinking and Their Effects on the Morphology, Mechanical and
Thermal Properties of Tapioca Starch Films. [Masters Thesis]. The Ohio State University; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1563494987482215

Michigan State University
9.
Katz, Sidney.
The fluorometric determination of citrate.
Degree: MS, 1946, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:8863
Subjects/Keywords: Citric acid; Fluorescence
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APA (6th Edition):
Katz, S. (1946). The fluorometric determination of citrate. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:8863
Chicago Manual of Style (16th Edition):
Katz, Sidney. “The fluorometric determination of citrate.” 1946. Masters Thesis, Michigan State University. Accessed January 16, 2021.
http://etd.lib.msu.edu/islandora/object/etd:8863.
MLA Handbook (7th Edition):
Katz, Sidney. “The fluorometric determination of citrate.” 1946. Web. 16 Jan 2021.
Vancouver:
Katz S. The fluorometric determination of citrate. [Internet] [Masters thesis]. Michigan State University; 1946. [cited 2021 Jan 16].
Available from: http://etd.lib.msu.edu/islandora/object/etd:8863.
Council of Science Editors:
Katz S. The fluorometric determination of citrate. [Masters Thesis]. Michigan State University; 1946. Available from: http://etd.lib.msu.edu/islandora/object/etd:8863

Rutgers University
10.
Fong, Stephanie Kay.
The genetics of organic acids variation in cranberry fruit.
Degree: PhD, Plant Biology, 2019, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/60677/
► American cranberry (Vaccinium macrocarpon Ait.) fruit are renowned for two traits; extreme sourness and their abundance of health-promoting compounds. Extreme sourness in cranberry fruit is…
(more)
▼ American cranberry (Vaccinium macrocarpon Ait.) fruit are renowned for two traits; extreme sourness and their abundance of health-promoting compounds. Extreme sourness in cranberry fruit is due to the high levels of malic, citric, and quinic acids, which together contribute to titratable acidity (TA). Commercially grown cranberries have a TA of 2.3-3.0%, well over two times the amount in most edible fruits. Thus, considerable amounts of ‘added-sugar’ are necessary for palatability. In addition to citric, malic, and quinic acids, cranberry fruit also have high levels benzoic acid. While benzoic acid does not statistically contribute to TA, but has health promoting benefits.
To ascertain the variation found in organic acids in existing breeding populations, four bi-parental crosses were phenotyped for malic, citric, quinic, and benzoic acids. Generally, the four organic acids displayed transgressive segregation to the parents. Genotyping by sequencing (GBS) was then used to map genetic diversity within the populations. A total of 61 QTLs were identified for the four organic acids.
In addition to the variation in organic acids in breeding populations, there were two accessions with unique genotypes from the germplasm collection with significantly lower citric acid (≈ 2 mg/g) (cita) and malic acid (≈ 2 mg/g) (mala). A series of crosses utilizing these accessions revealed that cita and mala are independently segregating Mendelian loci. A bulked segregant approach with simple sequence repeats (SSRs), then a QTL identification approach with single nucleotide polymorphisms (SNPs) generated through GBS was used to fine map these two traits. Two SSR markers and one SNP marker were identified for the cita locus while two SNP markers were identified for the mala locus.
The cita trait had multiple alleles contributing to differential levels of citric acid concentrations depending on the parent, e.g. Stevens or35. Both the cita and mala traits exhibit partial dominance. In two dihybrid crosses with both cita and mala, an epistatic effect was between these two traits. There was a significant effect of the cita alleles on increasing malic acid concentration while the presence of mala alleles reduced both citric and malic acid concentrations. This work determined the inheritance and variation of organic acids as well as developed molecular markers linked with low citric and low malic acid traits. These markers will be used for marker assisted selection to accelerate the breeding process of cranberry.
Advisors/Committee Members: Vorsa, Nicholi (chair), White, James (internal member), Gallavotti, Andrea (internal member), Mardekian, Jack (outside member), School of Graduate Studies.
Subjects/Keywords: Cranberries – Genetics; Malic acid; Citric acid; Quinic acid
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Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Fong, S. K. (2019). The genetics of organic acids variation in cranberry fruit. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/60677/
Chicago Manual of Style (16th Edition):
Fong, Stephanie Kay. “The genetics of organic acids variation in cranberry fruit.” 2019. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/60677/.
MLA Handbook (7th Edition):
Fong, Stephanie Kay. “The genetics of organic acids variation in cranberry fruit.” 2019. Web. 16 Jan 2021.
Vancouver:
Fong SK. The genetics of organic acids variation in cranberry fruit. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Jan 16].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60677/.
Council of Science Editors:
Fong SK. The genetics of organic acids variation in cranberry fruit. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60677/

Iowa State University
11.
Bradley, William.
Developing green processes for the conversion of biobased materials into pyrones.
Degree: 2019, Iowa State University
URL: https://lib.dr.iastate.edu/etd/17649
► The work disclosed in this dissertation implements bio-based material for new synthetic applications. The synthetic applications are corrosion inhibitors, plasticizers, and block copolymers. Triacetic Acid…
(more)
▼ The work disclosed in this dissertation implements bio-based material for new synthetic applications. The synthetic applications are corrosion inhibitors, plasticizers, and block copolymers. Triacetic Acid Lactone (TAL) is a bio-based molecule fermented from Saccharmyces cerevisiae. In the first chapter, we discuss the conversion of triacetic acid lactone to corrosion inhibitors. The synthesis utilizes a nucleophilic heterocycle undergoing conjugate addition with brominated TAL producing a corrosion inhibitor. Successful corrosion inhibitors were synthesized in moderate to good yields. The highest corrosion inhibitor efficiency was 88% for newly developed corrosion inhibitors.
In the second chapter we developed a methodology to generate -pyrones. This moiety was formed by a [3+3] reaction between a 1,3 dicarbonyl and dihaloacryloyl chloride. Bicyclic -pyrones could be transformed into 5-hydroxychomones by aromatization in good yields.
In the third chapter, we found new applications for citric and malic acid mixtures (similar to those found in fruit) by converting them into plasticizers. Citric and malic acid could be reacted together to form an -pyrone diacid in 76% yield. The reaction was conducted in concentrated sulfuric acid. The esters of citric and malic acid could also be reacted together to afford the diester pyrone.
In the fourth chapter, we combined anionic polymerization with reversible addition fragmentation chain transfer RAFT polymerization by the development of macro-chain transfer agent. The conversion of anionic polystyrene to block acrylic copolymers had an efficiency as high as 97%. This was completed by coupling -bromoisobutryl bromide, followed by atom-transfer radical addition fragmentation transfer with bis(thiobenzyl)disulfide to add the chain transfer agent functionality. The methodology of combining anionic polymerization with RAFT polymerization gave the highest blocking efficiency known in the literature.
Subjects/Keywords: Anionic; Citric acid; Corrosion Inhibitors; Malic Acid; Pyrones; Organic Chemistry
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MLA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Bradley, W. (2019). Developing green processes for the conversion of biobased materials into pyrones. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bradley, William. “Developing green processes for the conversion of biobased materials into pyrones.” 2019. Thesis, Iowa State University. Accessed January 16, 2021.
https://lib.dr.iastate.edu/etd/17649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bradley, William. “Developing green processes for the conversion of biobased materials into pyrones.” 2019. Web. 16 Jan 2021.
Vancouver:
Bradley W. Developing green processes for the conversion of biobased materials into pyrones. [Internet] [Thesis]. Iowa State University; 2019. [cited 2021 Jan 16].
Available from: https://lib.dr.iastate.edu/etd/17649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bradley W. Developing green processes for the conversion of biobased materials into pyrones. [Thesis]. Iowa State University; 2019. Available from: https://lib.dr.iastate.edu/etd/17649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University
12.
Liddle, John Raymond.
Nickel (II)-citric acid complex formation in aqueous solution.
Degree: MS, Chemistry, 1979, Massey University
URL: http://hdl.handle.net/10179/12904
► Titrimetric analysis of solutions of nickel(II) chloride and citric acid, H 3 L, has led to the characterization of four complexes in the acidic pH…
(more)
▼ Titrimetric analysis of solutions of nickel(II) chloride and citric acid, H
3
L, has led to the characterization of four complexes in the acidic pH range NiL
-
, NiHL, NiH
2
L
+
, and Nil
4-
2
. Equilibrium constants for the formation of these complexes are reported. Results from a visible spectrophotometric study are analysed in terms of these four complexes. The stability and possible structures of the complexes are discussed and compared with other nickel-carboxylic acid complexes.
Subjects/Keywords: Nickel;
Nickel compounds;
Citric acid;
Citric acid compounds
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APA (6th Edition):
Liddle, J. R. (1979). Nickel (II)-citric acid complex formation in aqueous solution. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/12904
Chicago Manual of Style (16th Edition):
Liddle, John Raymond. “Nickel (II)-citric acid complex formation in aqueous solution.” 1979. Masters Thesis, Massey University. Accessed January 16, 2021.
http://hdl.handle.net/10179/12904.
MLA Handbook (7th Edition):
Liddle, John Raymond. “Nickel (II)-citric acid complex formation in aqueous solution.” 1979. Web. 16 Jan 2021.
Vancouver:
Liddle JR. Nickel (II)-citric acid complex formation in aqueous solution. [Internet] [Masters thesis]. Massey University; 1979. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10179/12904.
Council of Science Editors:
Liddle JR. Nickel (II)-citric acid complex formation in aqueous solution. [Masters Thesis]. Massey University; 1979. Available from: http://hdl.handle.net/10179/12904

Clemson University
13.
Simpkins, Laura.
INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE.
Degree: MS, Environmental Engineering and Science, 2011, Clemson University
URL: https://tigerprints.clemson.edu/all_theses/1187
► Understanding plutonium geochemical behavior is imperative to the development of schemes for remediation of plutonium environmental contamination and accurate assessment of risks posed by the…
(more)
▼ Understanding plutonium geochemical behavior is imperative to the development of schemes for remediation of plutonium environmental contamination and accurate assessment of risks posed by the disposal of plutonium bearing wastes. The primary mechanism of plutonium mobility in the environment is subsurface transport. The mobility of plutonium is significantly influenced by redox and complexation reactions. Although the effects of surface mediated redox reactions on plutonium's subsurface mobility have been previously documented, little has been done to determine the impact of organic materials on sorption behavior and oxidation states. To adequately predict the behavior of plutonium in the environment, the influence of natural organic matter on plutonium geochemical behavior must be understood. This work primarily investigates the sorption of plutonium to gibbsite in the presence of organic material with the goal of accurately modeling the sorption behavior over the pH range 3-9. Sorption of plutonium to gibbsite in the presence of Suwannee River Fulvic
Acid Standard I, desferrioxamine B (DFOB),
citric acid, and Leonardite humic
acid was examined to determine the influence of organic ligand character on plutonium sorption. These organic materials are ubiquitous in the environment, and their presence generally drives plutonium to the tetravalent oxidation state in surface and ground waters. Batch sorption experiments involving ternary systems containing plutonium, gibbsite, and one of the studied organic materials at a concentration of 5 or 50 mg C/L have revealed a definite impact of the organic materials when compared with the binary system containing only plutonium and gibbsite. In the binary system, greater than 90% of the plutonium sorbed to the gibbsite. However, the addition of organic ligands altered the sorption behavior, dependent on the pH of the system. Using a surface complexation model, aqueous stability constants, and assuming the formation of ternary surface complexes, the results of the batch sorption experiments were modeled. The data and models achieved in this study will allow for more adequate predictions of the movement of plutonium in the environment when incorporated into geochemical models.
Advisors/Committee Members: Powell, Brian A, Finneran , Kevin, Schlautman , Mark.
Subjects/Keywords: citric acid; fulvic acid; humic acid; natural organic matter; plutonium; sorption; Environmental Engineering
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Simpkins, L. (2011). INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/1187
Chicago Manual of Style (16th Edition):
Simpkins, Laura. “INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE.” 2011. Masters Thesis, Clemson University. Accessed January 16, 2021.
https://tigerprints.clemson.edu/all_theses/1187.
MLA Handbook (7th Edition):
Simpkins, Laura. “INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE.” 2011. Web. 16 Jan 2021.
Vancouver:
Simpkins L. INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE. [Internet] [Masters thesis]. Clemson University; 2011. [cited 2021 Jan 16].
Available from: https://tigerprints.clemson.edu/all_theses/1187.
Council of Science Editors:
Simpkins L. INFLUENCE OF NATURAL ORGANIC MATTER ON PLUTONIUM SORPTION TO GIBBSITE. [Masters Thesis]. Clemson University; 2011. Available from: https://tigerprints.clemson.edu/all_theses/1187
14.
⼤森, 裕⼦.
Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発.
Degree: 博士(歯学), 2016, Osaka Dental University / 大阪歯科大学
URL: http://id.nii.ac.jp/1392/00000069/
► Various techniques for preparing ceramic nanoparticles have been developed; however, most of them start from a preparation of precursor nanoparticles that are generally amorphous or…
(more)
▼ Various techniques for preparing ceramic nanoparticles have been developed; however, most of them start from a preparation of precursor nanoparticles that are generally amorphous or in poorly crystallized phases. Thermal treatments used to obtain crystalline phases typically result in the sintering of the products into large polycrystals. In this study, we developed a process to fabricate dispersible hydroxyapatite (HAp; Ca10(PO4)6(OH)2) nanocrystals via a modified Pechini method, which is a sol-gel like solid-state synthesis method for the preparation of multicomponent oxides. We demonstrated that the HAp nanocrystals sintered into large polycrystals ranging in size from several tens to several hundreds of microns via a conventional Pechini method using the stoichiometric Ca/P molar ratio of 1.67. When the Ca/P molar ratio in the precursor was >1.67, a mixture of HAp nanocrystals and removable CaO matrix was obtained. The HAp nanocrystals were dispersed in aqueous media mostly in the form of nanoparticles when the amount of CaO matrix was sufficiently greater than the amount of HAp.
2014年度
Subjects/Keywords: Acrylic Resins; Citric Acid; Ethylene Glycol; Hydroxyapatites; Nanoparticles; Nanotechnology; Particle Size
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APA (6th Edition):
⼤森, . (2016). Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000069/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
⼤森, 裕⼦. “Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed January 16, 2021.
http://id.nii.ac.jp/1392/00000069/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
⼤森, 裕⼦. “Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発.” 2016. Web. 16 Jan 2021.
Vancouver:
⼤森 . Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Jan 16].
Available from: http://id.nii.ac.jp/1392/00000069/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
⼤森 . Fabrication of dispersible calcium phosphate nanocrystals via a modified Pechini method under non-stoichiometric conditions : 改良 Pechini 法による分散性リン酸カルシウムナノ粒⼦の開発. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000069/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
15.
Paulino, Carmen Emilia Caba.
Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura.
Degree: Mestrado, Reabilitação Oral, 2014, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-13102014-152339/
;
► A biomodificação radicular empregando ácido cítrico tem sido utilizada visando à reinserção dos tecidos periodontais a raízes expostas à doença periodontal. Entretanto, a grande diversidade…
(more)
▼ A biomodificação radicular empregando ácido cítrico tem sido utilizada visando à reinserção dos tecidos periodontais a raízes expostas à doença periodontal. Entretanto, a grande diversidade metodológica entre os estudos ainda não possibilitou o estabelecimento de um protocolo amplamente aceito quanto à concentração e tempo de aplicação do ácido. Assim, 32 dentes extraídos por doença periodontal avançada forneceram 63 fragmentos radiculares que, após raspagem manual, foram divididos nos seguintes grupos de tratamento: Grupo AC-10-90: desmineralização com ácido cítrico a 10% em pH 1, durante 90 segundos; Grupo AC-10-120: desmineralização com ácido cítrico a 10% em pH 1, durante 120 segundos; Grupo AC-10-180: desmineralização com ácido cítrico a 10% em pH 1, durante 180 segundos; Grupo AC-50-90: desmineralização com ácido cítrico a 50% em pH 1, durante 90 segundos; Grupo AC-50-120: desmineralização com ácido cítrico a 50% em pH 1, durante 120 segundos; Grupo AC-50-180: desmineralização com ácido cítrico a 50% em pH 1, durante 180 segundos; Grupo C (controle): lavagem com soro fisiológico. Sobre as superfícies tratadas foram cultivados fibroblastos do ligamento periodontal humano por 24, 48 e 72 horas. A ampliação dos túbulos dentinários, morfologia celular e a porcentagem das superfícies radiculares recobertas por células foram avaliadas em microscopia eletrônica de varredura. As imagens microscópicas das superfícies recobertas por células foram comparadas pelo teste não paramétrico de Kruskal-Wallis seguido pelo teste de Dunn e na ampliação dos túbulos pelo teste de variância a dois critérios (ANOVA) complementado pelo teste de Tukey, em 5% de significância, ambos realizados por um programa computadorizado comparando os resultados entre os grupos. A Com exceção do grupo C, em todos os grupos houve aumento crescente da cobertura da superfície radicular por fibroblastos com o tempo. A maior área de cobertura foi apresentada pelo grupo AC-10-90 (98,82±2,57%) às 24 horas e essa diferença foi significante (p<0,001) em comparação aos grupos AC-50-90 (64,94±20,60%), AC-50-180 (56,59±35,42%) e C (0,06±0,24%). Nas demais comparações de tempo de aplicação e tempo de cultura, predominou a superioridade dos grupos tratados por ácido cítrico a 10% sobre os de 50%, porém, sem significância estatística. Todos os grupos teste foram significantemente superiores aos controle em todos os tempos de cultura. O menor valor médio para o diâmetro dos túbulos dentinários expostos pelos tratamentos foi apresentado pelo grupo AC-10-90 (4,55±0,69 μm) que diferiu significantemente (p<0,001) dos grupos AC-10-120 (5,33±0,95 μm), AC-10-180 (5,54±1,56 μm) e AC-50-180 (5,56±1,22 μm). Esse último apresentou a maior ampliação, porém sem diferença significante em relação aos demais grupos. Os fibroblastos apresentaram-se mais espalhados, achatados e com menor definição de limites nos grupos tratados com ácido cítrico a 10% do que nos de 50%, cujas células apresentavamse fusiformes e arredondadas. Concluiu-se que o ácido cítrico a…
Advisors/Committee Members: Rezende, Maria Lucia Rubo de.
Subjects/Keywords: Ácido cítrico; Citric acid; Doença periodontal; Fibroblastos; Fibroblasts; Periodontal disease
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APA ·
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APA (6th Edition):
Paulino, C. E. C. (2014). Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/25/25146/tde-13102014-152339/ ;
Chicago Manual of Style (16th Edition):
Paulino, Carmen Emilia Caba. “Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura.” 2014. Masters Thesis, University of São Paulo. Accessed January 16, 2021.
http://www.teses.usp.br/teses/disponiveis/25/25146/tde-13102014-152339/ ;.
MLA Handbook (7th Edition):
Paulino, Carmen Emilia Caba. “Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura.” 2014. Web. 16 Jan 2021.
Vancouver:
Paulino CEC. Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Jan 16].
Available from: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-13102014-152339/ ;.
Council of Science Editors:
Paulino CEC. Efeito do protocolo de desmineralização por ácido cítrico na área de superfície radicular recoberta por fibroblastos do ligamento periodontal humano: estudo à microscopia eletrônica de varredura. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-13102014-152339/ ;
16.
Franklin, D S.
Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;.
Degree: 2015, Manonmaniam Sundaranar University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/38355
► Hydrogels are three dimensional polymeric structure with segments of newlinehydrophilic groups stimuli responsive hydrogels placed an attractive role towards newlinethe various researchers due to slight…
(more)
▼ Hydrogels are three dimensional polymeric structure
with segments of newlinehydrophilic groups stimuli responsive
hydrogels placed an attractive role towards newlinethe various
researchers due to slight modification of environment causes large
newlineabrupt change in their properties especially swelling
behaviour of hydrogels the newlinepresent investigation was aimed
to synthesis a series of citric acid based ph newlinesensitive
biopolymeric hydrogels using a solventless green approach via
newlinecondensation polymerization in the presence of acidic medium
the addition of newlineacrylic acid or methacrylic acid added into
pre polyester system resulted newlinebiopolymeric hydrogels
incorporation of ha has been prepared from waste newlineeggshells
resulted in biocomposite hydrogels the formation hydrogels and
their newlinecomposites were confirmed using various spectral
investigations newline newline
Advisors/Committee Members: Guhanathan, S.
Subjects/Keywords: biopolymeric; citric acid; green approach; Investigation; ph sensitive
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Franklin, D. S. (2015). Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/38355
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Franklin, D S. “Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;.” 2015. Thesis, Manonmaniam Sundaranar University. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/38355.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Franklin, D S. “Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;.” 2015. Web. 16 Jan 2021.
Vancouver:
Franklin DS. Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2015. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38355.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Franklin DS. Investigation on citric acid based ph sensitive
biopolymeric hydrogels and composites a solventless green
approach;. [Thesis]. Manonmaniam Sundaranar University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38355
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mahatma Gandhi University
17.
Sasi, P V.
Studies on chiral catalysis employing optically active
hydroxycitric acids;.
Degree: Chemistry, 2014, Mahatma Gandhi University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/25743
newline
Bibliography p. i-xii
Advisors/Committee Members: Ibnusaud, I.
Subjects/Keywords: Catalysis; Chirals; Hydroxy citric acid
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sasi, P. V. (2014). Studies on chiral catalysis employing optically active
hydroxycitric acids;. (Thesis). Mahatma Gandhi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/25743
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sasi, P V. “Studies on chiral catalysis employing optically active
hydroxycitric acids;.” 2014. Thesis, Mahatma Gandhi University. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/25743.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sasi, P V. “Studies on chiral catalysis employing optically active
hydroxycitric acids;.” 2014. Web. 16 Jan 2021.
Vancouver:
Sasi PV. Studies on chiral catalysis employing optically active
hydroxycitric acids;. [Internet] [Thesis]. Mahatma Gandhi University; 2014. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/25743.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sasi PV. Studies on chiral catalysis employing optically active
hydroxycitric acids;. [Thesis]. Mahatma Gandhi University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/25743
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Goss, Dale Mark.
Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions.
Degree: MSc, Biomedical Sciences, 2018, Stellenbosch University
URL: http://hdl.handle.net/10019.1/103288
► ENGLISH ABSTRACT: Various studies have sought to determine the typical versus optimal abstinence period after which semen samples should be collected, and many have been…
(more)
▼ ENGLISH ABSTRACT: Various studies have sought to determine the typical versus optimal abstinence period after which semen samples should be collected, and many have been found to be contradictory. Several factors influence the semen microenvironment and subsequent sperm basic and functional parameters. In this study we focused on important biomarkers of prostate, seminal vesicle and epididymal secretion. Furthermore, extensive proteomic analysis of seminal plasma was performed for a more comprehensive understanding of the observations. Semen samples were obtained from normozoospermic donors (n = 16) after 4 days and 4 hours of ejaculatory abstinence (EA) and standard semen analysis was performed with the assistance of computer aided sperm analysis (CASA), while the seminal plasma citric acid, neutral alpha-glucosidase and fructose concentrations were measured photometrically with commercially available assay kits. Protein identification was performed using advanced mass spectrometric techniques and pathways were analysed on both Reactome and String databases.
Results of this study displayed significant decreases in semen volume, sperm concentration, total sperm count, and pH after 4 hours of ejaculatory abstinence when compared to 4 days. Furthermore, increases in total sperm motility and progressive motility after short EA periods were observed, accompanied by significant reductions in all epididymal and accessory sex gland biomarker concentrations. However, due to the decreased sperm number, these concentrations translated to a significant increase in citric acid and a decrease in fructose available per spermatozoon, which, along with the effects on semen pH, could more than likely be responsible for increased metabolic function and subsequent increase in the available energy for sperm motility.
Proteomic analysis identified 22 differentially expressed seminal plasma proteins, with 18 proteins upregulated after 4 days of EA and 3 upregulated after 4 hours of EA. Of the proteins differentially expressed, 5 proteins from 4 days of EA and 2 proteins from 4 hours of EA, were identified to be related to sperm function and thus selected for pathway analysis.
proteins were found to be prominent components of cellular processes including metabolism, apoptosis and cell process regulation, which can be linked directly and indirectly to sperm motility parameters. To conclude, the mechanisms by which very short EA improves sperm motility depends on seminal plasma composition thereby affecting metabolic function and protein interactions.
AFRIKAANSE OPSOMMING: Verskeie studies het probeer om die tipiese versus optimale onthoudingsperiode te bepaal waarna semenmonsters versamel moet word, maar heelwat teenstrydighede is gevind. Verskeie faktore beïnvloed die semen mikro-omgewing en daaropvolgende sperm-basiese en funksionele parameters. In die huidige studie is daar gefokus op belangrike biomerkers in sekresies afkomstig vanaf die prostaat, seminale vesikels en epididimis. Uitgebreide proteomiese analises is ook op die…
Advisors/Committee Members: Du Plessis, Stefan S., Van der Horst, Gerhard, Stellenbosch University. Faculty of Health Sciences. Dept. of Biomedical Sciences : Medical Physiology..
Subjects/Keywords: Sexual abstinence; Citric acid; Fructose; Proteomics; Seminal plasma proteins; Sperm; UCTD
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Goss, D. M. (2018). Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/103288
Chicago Manual of Style (16th Edition):
Goss, Dale Mark. “Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions.” 2018. Masters Thesis, Stellenbosch University. Accessed January 16, 2021.
http://hdl.handle.net/10019.1/103288.
MLA Handbook (7th Edition):
Goss, Dale Mark. “Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions.” 2018. Web. 16 Jan 2021.
Vancouver:
Goss DM. Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions. [Internet] [Masters thesis]. Stellenbosch University; 2018. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10019.1/103288.
Council of Science Editors:
Goss DM. Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions. [Masters Thesis]. Stellenbosch University; 2018. Available from: http://hdl.handle.net/10019.1/103288

Penn State University
19.
Kalaba, Srdan Ha.
The Use of Citrate-Based Biomaterials for Hernia Repair.
Degree: 2016, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/28897
► The construction of physiologically suitable biomaterial prostheses for successful hernia repair remains a significant challenge within the field of tissue-engineering. Ideal prosthetic biomaterials should provide…
(more)
▼ The construction of physiologically suitable biomaterial prostheses for successful hernia repair remains a significant challenge within the field of tissue-engineering. Ideal prosthetic biomaterials should provide biomechanical stability to the abdominal wall, promote adequate tissue infiltration, decrease the risk of infection and scar tissue formation, and prevent intestinal adhesion development. In this study, we employed a novel approach to promote wound healing within the abdominal wall by creating layered, hierarchically porous tissue scaffolds using a soft, elastic, citrate based biodegradable photo-luminescent polymer (BPLP). These scaffolds were designed to provide a mechanical barrier for abdominal wall hernias while accelerating the tissue regeneration within the wound site. BPLP hernia scaffolds contain a unique three layer (wound, middle, protective) construction with varying porosities and pore sizes within each layer. The goal of this porosity gradient is to encourage cell in-growth, migration, and proliferation, while gradually transferring mechanical loads from prosthesis to newly generated tissues. Three different biodegradable photo-luminescent polymers, BPLP-Cys, BPLP-Cys-PEG (10%), and BPLP –Cys-MDEA (10%), were synthesized to fabricate scaffolds with ranging degradation rates. The design for each materials scaffold was identical and contained 80%, 60%, and 30% porosities for the wound adjacent, middle, and protective layers, respectively. The pore sizes for each layer starting with the wound layer and moving outward are 250µm, 100µm, and 10µm, respectively. Polymers were mechanically mixed with salt of varying sizes and concentrations combined with salt leaching post crosslinking to fabricate the porous nature of the tested scaffolds.
Additionally, the in vivo compliance of citrate based BPLP-Cys polymer coatings was tested on two commercially available hernia meshes, BardSoft® and DualMesh®. Coated and non-coated meshes were compared in order to determine potential benefits of citrate based biomaterials for hernia applications. Overall, the results of these studies suggest that the use of citrate based biomaterials for hernia repair may provide significant advantages over conventional permanent prostheses. In general, citrate based biomaterials appear to demonstrate more cytocompatible behavior by mitigating foreign body response, promoting cell infiltrations, and preventing intestinal adhesion formation.
Advisors/Committee Members: Jian Yang, Thesis Advisor/Co-Advisor.
Subjects/Keywords: Hernia repair; Hernia mesh; Hernia prosthesis; Hernia; Citric Acid; Citrate; Biomaterials
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kalaba, S. H. (2016). The Use of Citrate-Based Biomaterials for Hernia Repair. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/28897
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kalaba, Srdan Ha. “The Use of Citrate-Based Biomaterials for Hernia Repair.” 2016. Thesis, Penn State University. Accessed January 16, 2021.
https://submit-etda.libraries.psu.edu/catalog/28897.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kalaba, Srdan Ha. “The Use of Citrate-Based Biomaterials for Hernia Repair.” 2016. Web. 16 Jan 2021.
Vancouver:
Kalaba SH. The Use of Citrate-Based Biomaterials for Hernia Repair. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Jan 16].
Available from: https://submit-etda.libraries.psu.edu/catalog/28897.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kalaba SH. The Use of Citrate-Based Biomaterials for Hernia Repair. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/28897
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center
20.
Chen, Jun.
Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling.
Degree: 2017, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/7202
► The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, yeast mutants lacking…
(more)
▼ The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino
acid insufficiency. In glucose medium, yeast mutants lacking the function of this complex grow poorly in the absence of amino
acid supplementation, despite hallmarks of increased TORC1 signaling. Such mutants perceive they are amino
acid-replete and thus repress metabolic activities that are important for achieving this state. I find that npr2∆ mutants have defective mitochondrial TCA cycle activity and retrograde response. Supplementation of glutamine, and especially aspartate, which are nitrogen-containing forms of TCA cycle intermediates, rescue growth of npr2∆ mutants. These amino acids are then consumed in biosynthetic pathways that require nitrogen to support proliferative metabolism. Our findings reveal that negative regulators of TORC1 such as GATOR1/SEACIT regulate the cataplerotic synthesis of these amino acids from the TCA cycle in tune with the amino
acid and nitrogen status of cells.
Advisors/Committee Members: Liu, Yi, Tu, Benjamin, Phillips, Margaret A., Goodman, Joel M..
Subjects/Keywords: Citric Acid Cycle; Mitochondria; Multiprotein Complexes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, J. (2017). Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/7202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Jun. “Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling.” 2017. Thesis, University of Texas Southwestern Medical Center. Accessed January 16, 2021.
http://hdl.handle.net/2152.5/7202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Jun. “Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling.” 2017. Web. 16 Jan 2021.
Vancouver:
Chen J. Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2152.5/7202.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen J. Insights into the Metabolic Regulation by GATOR1 in Response to Amino Acid Signaling. [Thesis]. University of Texas Southwestern Medical Center; 2017. Available from: http://hdl.handle.net/2152.5/7202
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University
21.
HAILEMARIAM, FELEKE.
SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
.
Degree: 2012, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/294
► Citric acid is used in the food, beverage, pharmaceutical, chemical, cosmetic and other industries for applications such as acidulation, anti oxidation, flavour enhancement, preservation, and…
(more)
▼ Citric acid is used in the food, beverage, pharmaceutical, chemical, cosmetic and other industries
for applications such as acidulation, anti oxidation, flavour enhancement, preservation, and as a
synergistic agent. It is used to flavour the drinks, jams and jellies, candies, water ice and wines.
In recent years, a great deal of attention is given to alternative methods for
citric acid production
using agro-industrial residues. A
citric acid producing Aspergillus niger isolate designated as
ASGS was isolated from the Faculty of science Addis Ababa University green house soil. The
isolate produced
citric acid in solid state fermentation (SSF) using different agricultural products
and by products (Maize, Rice and wheat bran) as substrates. Out of the three substrates, rice(R)
was found to be better followed by the combination of wheat bran and rice (WR). The highest
level of
citric acid (110.6g/kg DR) was produced in Rice, with Rice-to- moisture ratio of 1:4
(w/v) at 30 °C and 72 hr. The weakest substrate for citrate fermentation was wheat bran with only
7g/kg citrate production. Maximum growth of the isolate was shown at 30◦c, it also showed
growth and biomass accumulation at 35◦c. Wrinkled, dense, white mycelium was observed in
the flask at 30◦c while at 25◦c was not shown. Citrate accumulation increased exponentially after
48hrs of fermentation and the maximum
citric acid (82.6g/kg DR) was obtained at 72hr which
declined gradually. Initial rice moisture content had a considerable effect on
citric acid
production by ASGS. A maximum
citric acid production (91g/kg DR) was obtained with 80%
moisture content. Citrate accumulation also increased significantly with increase in temperature
from 25 to 30◦c and production slightly declined up to 35◦c. The highest value of
citric acid
concentration (98g/kg DR) was achieved at an initial pH of 4.5. Recovery trial yielded 1.2g
citric
acid from 10g of dry rice substrate which was white and solid crystalline.
Advisors/Committee Members: Dr. Dawit Abate (advisor).
Subjects/Keywords: Citric acid;
Solid state fermentation;
Aspergillus niger strain
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
HAILEMARIAM, F. (2012). SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/294
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
HAILEMARIAM, FELEKE. “SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
.” 2012. Thesis, Addis Ababa University. Accessed January 16, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/294.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
HAILEMARIAM, FELEKE. “SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
.” 2012. Web. 16 Jan 2021.
Vancouver:
HAILEMARIAM F. SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
. [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Jan 16].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/294.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
HAILEMARIAM F. SMALL-SCALE CITRIC ACID PRODUCTION ON SOLID-STATE FERMENTATION USING ASPERGILLUS NIGER
. [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/294
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
22.
Zhong, Shuping.
Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
.
Degree: 2015, University of Ottawa
URL: http://hdl.handle.net/10393/32204
► The methylotrophic yeast Pichia pastoris has become an efficient expression system for heterologous protein production. Different methods have been studied to enhance cell growth as…
(more)
▼ The methylotrophic yeast Pichia pastoris has become an efficient expression system for heterologous protein production. Different methods have been studied to enhance cell growth as well as the production of products of interest. Two of the major strategies for improving the product or biomass yields are optimizing bioprocess controls and cultivation conditions. In this work, the characteristics of this yeast system and of its different promoters are discussed, and the effect of operational strategies on cell growth and recombinant protein expression is also studied. The effect of different feeding strategies were studied and optimized for pGAP (glyceraldehyde-3-phosphate dehydrogenase)-regulated phytase production in P. pastoris. Alternative carbon sources were screened and the feasibility of using citric acid as a carbon source for recombinant protein production was also investigated. The effects of parameters such as the carbon source concentration and culture pH were studied using shake-flasks, and the effect of different feeding profiles on bioreactor performance was also investigated. Three feeding strategies, Stepwise feeding, Exponential feeding and DO-stat feeding were tested and DO-stat was found to be more efficient and led to a high phytase activity. A modified DO-stat method was investigated to overcome the oxygen limited condition in the standard DO-stat method. For the carbon source, citric acid showed promise in improving phytase expression. Further experiments in bioreactors performed with the
presence of certain amount of citric acid showed that less glycerol could be used to achieve the same level of phytase activity.
Subjects/Keywords: Pichia pastoris;
Yeast;
Carbon source;
Citric acid;
Fermentation;
Feeding strategy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhong, S. (2015). Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/32204
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhong, Shuping. “Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
.” 2015. Thesis, University of Ottawa. Accessed January 16, 2021.
http://hdl.handle.net/10393/32204.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhong, Shuping. “Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
.” 2015. Web. 16 Jan 2021.
Vancouver:
Zhong S. Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
. [Internet] [Thesis]. University of Ottawa; 2015. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10393/32204.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhong S. Study of Operational Strategies and Carbon Source Selection for the Production of Phytase using Pichia pastoris
. [Thesis]. University of Ottawa; 2015. Available from: http://hdl.handle.net/10393/32204
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape
23.
Motsoeneng, Khothatso Patricia.
The toxicity of silver nanoparticles
.
Degree: 2012, University of the Western Cape
URL: http://hdl.handle.net/11394/4700
► Unavailability and contamination of available water resources are major factors contributing to adverse health conditions worldwide. AgNPs present a potential strategy for water purification; however,…
(more)
▼ Unavailability and contamination of available water resources are major factors contributing to adverse health conditions worldwide. AgNPs present a potential strategy for water purification; however, their ability to accumulate in organs such as the kidneys, lungs and spleen is a possible source of toxicity. This study investigates the toxicity of AgNPs to Saccharomyces cerevisiae (S. cerevisiae). S. cerevisiae is an excellent model organism for assessing toxic compounds that affect eukaryotic organisms due to their ease of cultivation. AgNPs were prepared by photo-reduction of silver nitrate with OSRAM Vitalux lamp (300 W and 230 V) in the presence of stabilizing agents such as polyvinylpyrrolidone and
citric acid, yielding AgNPs. The effects of varying the concentration of the stabilizing agent, time of exposure to the light source, and pH were investigated. The formation of AgNPs was analysed by ultra-violet spectroscopy (UV-Vis) and transmission electron microscope techniques. The results showed that the AgNPs absorbed ultra-violet radiation between 400 and 500 nm and TEM images showed the particles to be both spherical and needle-like in shape. The shapes of the AgNPs were largely dependent on the synthesis method applied. The toxicity of AgNPs was assessed using metabolic activity of yeast cells as biomarker andmonitored with of the chromogenic assay, XTT. S. cerevisiae was introduced into different concentrations of AgNPs and incubated at 37 °C for 72 h. After the incubation, XTT assay was performed to assess the cell viability. The XTT results showed that high concentration of AgNPs (100 µg/mL) inhibited the growth of S. cerevisiae. The synthesis of AgNPs and theassessment of their toxicity on S. cerevisiae was thus undertaken and established in this work.
Advisors/Committee Members: Pool, Edmund J (advisor), Petrik, Leslie (advisor).
Subjects/Keywords: Silver nanoparticles;
Water purification;
Citric acid;
Chromogenic assay
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APA (6th Edition):
Motsoeneng, K. P. (2012). The toxicity of silver nanoparticles
. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4700
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Motsoeneng, Khothatso Patricia. “The toxicity of silver nanoparticles
.” 2012. Thesis, University of the Western Cape. Accessed January 16, 2021.
http://hdl.handle.net/11394/4700.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Motsoeneng, Khothatso Patricia. “The toxicity of silver nanoparticles
.” 2012. Web. 16 Jan 2021.
Vancouver:
Motsoeneng KP. The toxicity of silver nanoparticles
. [Internet] [Thesis]. University of the Western Cape; 2012. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11394/4700.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Motsoeneng KP. The toxicity of silver nanoparticles
. [Thesis]. University of the Western Cape; 2012. Available from: http://hdl.handle.net/11394/4700
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University
24.
Johnson, Heather Enid.
Natural products as potential herbicide adjuvants : citric acid esters and quercetin.
Degree: MS, Department of Crop and Soil Sciences, 2000, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:32031
Subjects/Keywords: Herbicides; Citric acid; Quercetin
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Johnson, H. E. (2000). Natural products as potential herbicide adjuvants : citric acid esters and quercetin. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:32031
Chicago Manual of Style (16th Edition):
Johnson, Heather Enid. “Natural products as potential herbicide adjuvants : citric acid esters and quercetin.” 2000. Masters Thesis, Michigan State University. Accessed January 16, 2021.
http://etd.lib.msu.edu/islandora/object/etd:32031.
MLA Handbook (7th Edition):
Johnson, Heather Enid. “Natural products as potential herbicide adjuvants : citric acid esters and quercetin.” 2000. Web. 16 Jan 2021.
Vancouver:
Johnson HE. Natural products as potential herbicide adjuvants : citric acid esters and quercetin. [Internet] [Masters thesis]. Michigan State University; 2000. [cited 2021 Jan 16].
Available from: http://etd.lib.msu.edu/islandora/object/etd:32031.
Council of Science Editors:
Johnson HE. Natural products as potential herbicide adjuvants : citric acid esters and quercetin. [Masters Thesis]. Michigan State University; 2000. Available from: http://etd.lib.msu.edu/islandora/object/etd:32031

University of Arkansas
25.
Stackhouse, Ryan.
Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef.
Degree: MS, 2016, University of Arkansas
URL: https://scholarworks.uark.edu/etd/1752
► In two experiments, dark-cutting (DC) beef strip loins were used to test the effects of citric acid-enhancement pH on visual and instrumental color of…
(more)
▼ In two experiments, dark-cutting (DC) beef strip loins were used to test the effects of
citric acid-enhancement pH on visual and instrumental color of fresh and cooked steaks. Dark cutting and normal pH strip loin were injected to 111% of raw product weight with pH 3.5, 4.0, 4.5, or 5.0 solutions by mixing
citric acid in either 0.05% phosphate solution or tap water (Exp 1), or with pH 2.0, 2.5, 3.0, and 3.5 solutions made by mixing
citric acid in either a 0.5% orthophosphate solution (PO4) or a 0.5% tripolyphosphate solution (STP) (Exp2). Loin sections were cut into 2.5-cm-thick steaks and assigned to either simulated retail display for five days or cooked. Post-enhancement pH of enhanced DC steaks did not (P ≥ 0.180) differ from that of non-enhanced DC steaks, regardless of solution pH (Exp 1); however, decreased linearly (P < 0.001) as solution pH decreased from 3.5 to 2.0, and the proportions of free and bound moisture of DC steaks enhanced with pH 2.5 solution were comparable (P ≥ 0.141) to that of CH (Exp 2). On d 1 and 3 of display, fresh color scores of enhanced DC steaks were greater (P < 0.001) than untreated DC (Exp 1), but color scores of CH steaks were greater (P < 0.001) than enhanced DC steaks (Exp 1 and 2). Conversely, in experiment 1, degree of doneness scores increased linearly (indicating greater doneness; P = 0.032) as solution pH increased from 3.5 to 5.0, and steaks enhanced with pH 4.0 and 4.5 solutions received lower (more red; quadratic, P = 0.012) cooked color scores than non-enhanced DC steaks, but neither score was comparable (P < 0.001) to those for CH steaks. While in experiment 2 enhancing DC sections with pH 2.5 solutions produced cooked color and degree of doneness scores that were similar (P ≥ 0.113) to non-enhanced CH steaks. Thus, enhancement with pH 2.5
citric acid solutions can effectively eliminate the persistent red cooked color typically associated with DC beef; however,
citric acid enhancement failed to improve the fresh color of DC beef comparable to that of CH beef.
Advisors/Committee Members: Jason K. Apple, Casey M. Owens-Hanning, Steven C. Seideman.
Subjects/Keywords: Biological sciences; Citric acid enhancement; Color; Dark-cutting beef; Meat Science
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Stackhouse, R. (2016). Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef. (Masters Thesis). University of Arkansas. Retrieved from https://scholarworks.uark.edu/etd/1752
Chicago Manual of Style (16th Edition):
Stackhouse, Ryan. “Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef.” 2016. Masters Thesis, University of Arkansas. Accessed January 16, 2021.
https://scholarworks.uark.edu/etd/1752.
MLA Handbook (7th Edition):
Stackhouse, Ryan. “Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef.” 2016. Web. 16 Jan 2021.
Vancouver:
Stackhouse R. Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef. [Internet] [Masters thesis]. University of Arkansas; 2016. [cited 2021 Jan 16].
Available from: https://scholarworks.uark.edu/etd/1752.
Council of Science Editors:
Stackhouse R. Effects of Enhancement Solution pH on Fresh and Cooked Color of Dark-Cutting Beef. [Masters Thesis]. University of Arkansas; 2016. Available from: https://scholarworks.uark.edu/etd/1752

Massey University
26.
Nutter, Anne-Marie.
Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant.
Degree: M. Phil., Food Technology, 1997, Massey University
URL: http://hdl.handle.net/10179/12411
► Citric acid production from yeasts has been studied widely owing to the short duration of fermentation, the broad choice of carbon source and the better…
(more)
▼ Citric acid production from yeasts has been studied widely owing to the short duration of fermentation, the broad choice of carbon source and the better yields obtained when compared to the currently used submerged or surface fermentation with Aspergillus niger. In this work two strains of Candida guilliermondii were compared for their citric acid-producing capabilities, these being parent strain Candida guilliermondii NRRL Y-448, and mutant strain Candida guilliermondii IMK1. The mutant was previously selected for its ability to produce much higher concentrations of citric acid than the parent. These strains were grown under various nutrient limitations to determine if nutrient limitation had an effect on the amount of citric acid produced. Several differences were observed between the non-citric acid-producing parent and the citric acid-producing mutant. The mutant generally consumed less glucose (g.g-1), produced less biomass (g.L-1) and produced much higher levels of citric acid – the best production (7.34 g.g-1) seen from the culture grown under phosphorus-limited (0.15 mM) conditions. Upon assessment of enzyme activities it was found that the mutant also exhibited reduced activity of the enzyme NAD-ICDH (NAD-dependent isocitrate dehydrogenase), a recognised control point for the over-production of citric acid. NAD-ICDH is inhibited by increased concentrations of ATP - these are associated with the accumulation of citric acid in the cell in the stationary phase of growth. This reduction in NAD-ICDH activity correlated with a dramatic increase in the activity of NADP-ICDH (NADP-specific isocitrate dehydrogenase), the activity of which was thought to compensate for the loss of activity of NAD-ICDH. However, in a subsequent experiment, the mutant was found to have reverted - losing its ability to produce citric acid. This loss of productivity occurred before the levels of adenine nucleotides in the cell could be assessed, meaning that the suggested inhibition of NAD-ICDH by elevated levels of ATP could not be confirmed. Upon analysis of the revertant, it was found that glucose consumption (grams per gram of cells) had increased, as had the production of biomass (g.L-1). Even though the revertant failed to consume as much glucose as the parent, in many instances it produced higher levels of biomass. Upon analysis of enzyme activity, it was found that the activity of NAD-ICDH had increased, so reducing the accumulation of citric and isocitric acids. The activity of NADP-ICDH had decreased somewhat, but activity of this enzyme remained at significant levels. It is proposed that the activity of NADP-ICDH in the revertant was responsible for the increased efficiency of biomass production. In conclusion, it is suggested that overproduction of citric acid in Candida guilliermondii IMK1 was due to the consumption of lowered levels of glucose combined with the reduced activity of the enzyme NAD-ICDH, which it is speculated was due to elevated concentrations of ATP in the cell.
Subjects/Keywords: Citric acid;
Yeast;
Candida guilliermondii
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nutter, A. (1997). Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/12411
Chicago Manual of Style (16th Edition):
Nutter, Anne-Marie. “Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant.” 1997. Masters Thesis, Massey University. Accessed January 16, 2021.
http://hdl.handle.net/10179/12411.
MLA Handbook (7th Edition):
Nutter, Anne-Marie. “Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant.” 1997. Web. 16 Jan 2021.
Vancouver:
Nutter A. Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant. [Internet] [Masters thesis]. Massey University; 1997. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10179/12411.
Council of Science Editors:
Nutter A. Citric acid production from yeasts : comparison of a parent and a mutant strain of Candida guilliermondii, and subsequent reversion of the mutant. [Masters Thesis]. Massey University; 1997. Available from: http://hdl.handle.net/10179/12411

Massey University
27.
Leangon, Sirichom.
Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation.
Degree: PhD, Process and Environmental Technology, 1996, Massey University
URL: http://hdl.handle.net/10179/2844
► The main purpose of this work was to study the mechanism of citric acid accumulation in solid state fermentation of Aspergillus niger. Two strains, Yang…
(more)
▼ The main purpose of this work was to study the mechanism of citric acid accumulation in solid state fermentation of Aspergillus niger. Two strains, Yang No.2 and MH 15-15, represented the high-accumulating organisms from which the low-accumulating mutants, SL-1 and SL-2, were generated by ultraviolet treatment. Comparative solid state fermentations, with a starch-containing material as the substrate, were conducted in petri-dishes, a technique which conferred a major advantage in allowing recovery of metabolically active mycelia for biochemical assays. Apart from the decreased citric acid accumulation, the selected mutants displayed lower starch consumption and enhanced production of oxalic acid, while their growth were generally equal to that of their respective parents. Evidence on elevated levels of free glucose in the cultures of the mutants, despite there being no alteration of α- amylase and glucoamylase from their parents, has prompted a hypothesis that the mutants were defective in the rates of glucose uptake. The biochemical work started with the primary steps of carbon assimilation, viz measurement of glucose uptake and activity assay of hexokinase. The results confirmed the reduced glucose uptake rates by the mutants and a hypothesis that this is caused by some defects in certain components of the glucose transport mechanism, but not at membrane ATPase, has been proposed. In addition, hexokinase showed higher in vitro activities in the parents and, presumably, their glycolytic fluxes were greater than those of their mutants. Investigation of activities of some selected TCA cycle enzymes and other metabolic steps in vitro strongly indicated the decreased activity of 2-oxoglutarate dehydrogenase and, possibly, NAD-and NADP-specific isocitrate dehydrogenases in the parents. Although most other enzymes decreased their activities during the later phase of cultivation, there was no definite difference between each parent and its mutant. However, oxaloacetate hydrolase, for oxalate formation, was at higher activity in the mutants than in the parents. Measurements of intracellular concentrations of products of certain enzymes and adenine nucleotides were conducted in order to assess the in vivo catalytic function of the enzymes of interest. It was concluded that internal accumulation of citrate or oxalate is an immediate cause of its excretion. Supplemented by evidence from the ratio of ATP/AMP in the cells, a complete hypothesis describing citrate accumulation in A.niger Yang No.2 and MH 15-15 is proposed. Hence, the rate by which glucose is taken up into the cells is the primary trigger determining the capacity of glycolytic metabolism and it is proposed that the primary cause of citric acid accumulation in the high-accumulating strains is the deregulation of glucose uptake. When the glucose supply exceeds the requirement of the cells, i.e. when growth is slow, the TCA cycle is balanced by allosteric deactivation of isocitrate dehydrogenases by ATP which is excessively generated via the active glycolysis. The…
Subjects/Keywords: Citric acid;
Aspergillus niger;
Fermentation
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leangon, S. (1996). Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/2844
Chicago Manual of Style (16th Edition):
Leangon, Sirichom. “Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation.” 1996. Doctoral Dissertation, Massey University. Accessed January 16, 2021.
http://hdl.handle.net/10179/2844.
MLA Handbook (7th Edition):
Leangon, Sirichom. “Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation.” 1996. Web. 16 Jan 2021.
Vancouver:
Leangon S. Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation. [Internet] [Doctoral dissertation]. Massey University; 1996. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10179/2844.
Council of Science Editors:
Leangon S. Mechanism of citric acid accumulation by Aspergillus niger in solid state fermentation. [Doctoral Dissertation]. Massey University; 1996. Available from: http://hdl.handle.net/10179/2844

Massey University
28.
Lu, Minyuan.
Citric acid production using Aspergillus niger by solid substrate fermentation.
Degree: PhD, Process and Environmental Technology, 1995, Massey University
URL: http://hdl.handle.net/10179/2965
► The aim of this work was to investigate solid substrate fermentation for citric acid production using Aspergillus niger, in an attempt to provide systematic information…
(more)
▼ The aim of this work was to investigate solid substrate fermentation for citric acid production using Aspergillus niger, in an attempt to provide systematic information and an understanding of the process. Initial experiments were performed to select an appropriate substrate and organism. Thus, kumara and a strain of Aspergillus niger, Yang No.2 were found favourable for citric acid production, while potato was a poor substrate due to its excessive nitrogen content. The fermentations were earned out under various conditions, i.e. inoculum size, moisture content and particle size of the substrate to optimize these parameters. Inoculum sizes between 10 4 and 10 6 spores/40 g kumara, moisture contents between 65 and 71% and particle sizes between 4 and 6 mm were optimal for citric acid production. It was found that the organism takes up nutrient by penetrating into the substrate, thus the fermentation had a direct relationship with the available surface area. The solid substrate was found to have the potential ability to overcome the adverse effect of high concentrations of metal ions. Addition of 150 mg/kg substrate of Fe2+, 25 mg/kg substrate of Cu2+, 75 mg/kg substrate of Zn2+ and 150 mg/kg substrate of Mn2+ had slightly stimulatory effects on citric acid production rather than inhibitory effects. Based on the optimized conditions, the kinetics of the solid substrate fermentation in flasks were studied. The maximum observed gravimetric rate, maximum observed specific rate and overall productivity of citric acid production were 1.5 g/kg.h, 122 mg/g.biomass.h and 0.48 g/kg.h, respectively. To develop the solid substrate fermentation process, experiments were performed in different types of reactors, including a gas-solid fluidized bed, a gas-liquid-solid fluidized bed, a rotating drum and a packed bed. Except for the packed bed reactor, these systems were found to be unsuitable for the fermentation, due to harsh conditions of abrasion, friction, low moisture supply, or combinations of these factors. The fermentation in the packed bed reactor was optimized with respect to air flow rate, bed loading and particle size. Based on these optimized conditions, the kinetics were studied, and it was determined that the fermentation allowed much higher rates of citric acid production than were observed in flasks, i.e. a maximum observed gravimetric rate of 1.9 g/kg.h and an overall productivity of 0.82 g/kg.h. In an attempt to understand mass and heat transfer in the solid substrate fermentation, experiments were conducted in a multi-layer packed bed reactor. However, because of the complexity of mass transfer in solid substrate fermentation, the understanding of this aspect in this process was rather limited. Nevertheless, the multi-layer packed bed reactor improved the mass transfer considerably compared with the single layer packed bed with the same bed loading, and allowed precise measurement of the gradients for gases, citric acid, biomass and starch. The results suggest that the multi-layer packed bed reactor is a suitable…
Subjects/Keywords: Citric acid;
Fermentation;
Aspergillus niger
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lu, M. (1995). Citric acid production using Aspergillus niger by solid substrate fermentation. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/2965
Chicago Manual of Style (16th Edition):
Lu, Minyuan. “Citric acid production using Aspergillus niger by solid substrate fermentation.” 1995. Doctoral Dissertation, Massey University. Accessed January 16, 2021.
http://hdl.handle.net/10179/2965.
MLA Handbook (7th Edition):
Lu, Minyuan. “Citric acid production using Aspergillus niger by solid substrate fermentation.” 1995. Web. 16 Jan 2021.
Vancouver:
Lu M. Citric acid production using Aspergillus niger by solid substrate fermentation. [Internet] [Doctoral dissertation]. Massey University; 1995. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10179/2965.
Council of Science Editors:
Lu M. Citric acid production using Aspergillus niger by solid substrate fermentation. [Doctoral Dissertation]. Massey University; 1995. Available from: http://hdl.handle.net/10179/2965

University of British Columbia
29.
Gillespie, Douglas Charles.
Metabolic studies on ASPERGILLUS NIGER 72-4.
Degree: MS- MSc, Animal Science, 1951, University of British Columbia
URL: http://hdl.handle.net/2429/40854
► Recent data on the effect of trace elements on the production of citric acid by Aspergillus niger 72-4 suggested that at last a firm basis…
(more)
▼ Recent data on the effect of trace elements on the production of citric acid by Aspergillus niger 72-4 suggested that at last a firm basis had been established for studies on the mechanism of production. Citric acid production is an important commercial process and most research had been directed toward obtaining high yields of the acid. The small amount of information on mechanisms is invalidated by the new knowledge of the importance of trace minerals in citric acid synthesis. The attempt at elucidating a system was approached by studying the distribution of organic phosphates in the mats and by manometric experiments. By using the Umbreit fractionation method combined with chromatographic analysis none of the phosphorylated intermediates present in the Embden-Meyerhof system could be identified. Evidence for a pentose and a ketose phosphate is presented. The manometric studies on still cultures were unsatisfactory due to a high endogenous rate and to difficulties in handling the mat. Shake cultures grown for four days and then depleted for 24 hours in the medium minus sucrose and manganese were shown to be a workable method for manometric studies. Using this method evidence for the presence of most of the enzymes required for the oxidation of the Krebs cycle intermediates is presented. A survey of the literature on cell preparations was made. Attempts to prepare active cell preparations failed since enzyme activity seems to be associated with the structural integrity of the mycelium.
Subjects/Keywords: Aspergillus niger.; Citric acid.
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gillespie, D. C. (1951). Metabolic studies on ASPERGILLUS NIGER 72-4. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/40854
Chicago Manual of Style (16th Edition):
Gillespie, Douglas Charles. “Metabolic studies on ASPERGILLUS NIGER 72-4.” 1951. Masters Thesis, University of British Columbia. Accessed January 16, 2021.
http://hdl.handle.net/2429/40854.
MLA Handbook (7th Edition):
Gillespie, Douglas Charles. “Metabolic studies on ASPERGILLUS NIGER 72-4.” 1951. Web. 16 Jan 2021.
Vancouver:
Gillespie DC. Metabolic studies on ASPERGILLUS NIGER 72-4. [Internet] [Masters thesis]. University of British Columbia; 1951. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2429/40854.
Council of Science Editors:
Gillespie DC. Metabolic studies on ASPERGILLUS NIGER 72-4. [Masters Thesis]. University of British Columbia; 1951. Available from: http://hdl.handle.net/2429/40854

Michigan State University
30.
Sinha, Dineshwar Prasad.
Evaluation of citric acid as a possible treatment for streptcoccic mastitis.
Degree: MS, Dept. of Surgery and Medicine, 1964, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:13065
Subjects/Keywords: Udder – Diseases; Citric acid
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Sinha, D. P. (1964). Evaluation of citric acid as a possible treatment for streptcoccic mastitis. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:13065
Chicago Manual of Style (16th Edition):
Sinha, Dineshwar Prasad. “Evaluation of citric acid as a possible treatment for streptcoccic mastitis.” 1964. Masters Thesis, Michigan State University. Accessed January 16, 2021.
http://etd.lib.msu.edu/islandora/object/etd:13065.
MLA Handbook (7th Edition):
Sinha, Dineshwar Prasad. “Evaluation of citric acid as a possible treatment for streptcoccic mastitis.” 1964. Web. 16 Jan 2021.
Vancouver:
Sinha DP. Evaluation of citric acid as a possible treatment for streptcoccic mastitis. [Internet] [Masters thesis]. Michigan State University; 1964. [cited 2021 Jan 16].
Available from: http://etd.lib.msu.edu/islandora/object/etd:13065.
Council of Science Editors:
Sinha DP. Evaluation of citric acid as a possible treatment for streptcoccic mastitis. [Masters Thesis]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:13065
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