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1. Petersen, Laura Esteves. A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide.

Degree: 2018, Pontifical Catholic University of Rio Grande do Sul

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

Rheumatoid Arthritis (RA) is an autoimmune and inflammatory disease which leads to premature immunosenescence and the development of articular and extra-articular manifestations, including joint damage and cognitive dysfunction, respectively. Peripheral immune system cells and the chronic inflammation, both of great importance for RA, are potentials mechanisms involved in cognitive dysfunction. In contrast, experimental studies have shown the beneficial contribution of immune cells, mainly T cells reactive to central nervous system (CNS) antigens, to neurogenesis and neuroplasticity. Previous data have shown that RA patients besides to have worse performance in cognitive tests, have significantly lower levels of B cells and higher levels of senescent T cells (CD8+CD28-). However, is not known yet which B cells subpopulations are related to poor cognitive performance, if clinical severity of disease (active and controlled disease) impacts on cognition and which factor is responsible for remodeling of peripheral immunity (immunosenescence). Hypotheses about the contribution of latent infections (Cytomegalovirus; CMV), for the development of immunosenescence (observed by telomere shortening and increase of CD28- cells) have been raised. However, it remains in discussion the CMV soroprevalence and its relation with the development of premature immunological senesce in RA. Based on this findings, in this work we have broadly assessment the cognition of RA patients with active and controlled disease, peripheral levels of lymphocytes subsets (T and B cells), neurotrophic factors, cytokines besides that CMV soroprevalence and immunosenescence profile (telomere length and CD28- cells). This work also proposed to explore the relationship between immune mediators, neurotrophic factors and cognitive performance, besides the association between CMV and immunosenescence. For this purpose, 102 RA patients (67 active and 35 controlled disease) and 30 healthy controls adjusted for age, gender and schooling were recruited. The cognitive function, levels of stress and depression were assessment by means of neurocognitive tests (Mini Mental State Examination, Logical memory, digit span, Trail Making Test, N-back, Stroop word-colors) and specific questionnaires (Beck Depression Inventory ?II for…

Advisors/Committee Members: Bauer, Mois?s Evandro.

Subjects/Keywords: Artrite Reumatoide; Cogni??o; C?lulas B; Citocinas; Fatores Neurotr?ficos; Imunossenesc?ncia Prematura; Citomegalov?rus; CIENCIAS BIOLOGICAS::BIOLOGIA GERAL

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APA (6th Edition):

Petersen, L. E. (2018). A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide. (Doctoral Dissertation). Pontifical Catholic University of Rio Grande do Sul. Retrieved from http://tede2.pucrs.br/tede2/handle/tede/7984

Chicago Manual of Style (16th Edition):

Petersen, Laura Esteves. “A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide.” 2018. Doctoral Dissertation, Pontifical Catholic University of Rio Grande do Sul. Accessed April 12, 2021. http://tede2.pucrs.br/tede2/handle/tede/7984.

MLA Handbook (7th Edition):

Petersen, Laura Esteves. “A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide.” 2018. Web. 12 Apr 2021.

Vancouver:

Petersen LE. A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide. [Internet] [Doctoral dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2018. [cited 2021 Apr 12]. Available from: http://tede2.pucrs.br/tede2/handle/tede/7984.

Council of Science Editors:

Petersen LE. A rela??o entre biomarcadores perif?ricos e fun??es cognitivas em pacientes com artrite reumat?ide. [Doctoral Dissertation]. Pontifical Catholic University of Rio Grande do Sul; 2018. Available from: http://tede2.pucrs.br/tede2/handle/tede/7984

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