subject:(Circadian Rhythm)

1. 伊藤, 太一. Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析.

Degree: 博士（理学）, 2013, Kyushu University / 九州大学

URL: http://hdl.handle.net/2324/21714 ; http://dx.doi.org/10.15017/21714

► ATP-binding cassette transporters (ABC transporters) are a kind of membrane proteins, which bind ATP and use the energy to drive the transport of various molecules… (more)

Subjects/Keywords: Drosophila; circadian rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

伊藤, �. (2013). Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析. (Thesis). Kyushu University / 九州大学. Retrieved from http://hdl.handle.net/2324/21714 ; http://dx.doi.org/10.15017/21714

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

伊藤, 太一. “Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析.” 2013. Thesis, Kyushu University / 九州大学. Accessed April 11, 2021. http://hdl.handle.net/2324/21714 ; http://dx.doi.org/10.15017/21714.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

伊藤, 太一. “Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析.” 2013. Web. 11 Apr 2021.

Vancouver:

伊藤 �. Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析. [Internet] [Thesis]. Kyushu University / 九州大学; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2324/21714 ; http://dx.doi.org/10.15017/21714.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

伊藤 �. Behavioral and molecular studies on membrane-bound transporters implicated in the circadian rhythm of Drosophila melanogaster. : ショウジョウバエ概日時計に関与する膜タンパク質の行動分子遺伝学的解析. [Thesis]. Kyushu University / 九州大学; 2013. Available from: http://hdl.handle.net/2324/21714 ; http://dx.doi.org/10.15017/21714

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

2. Timothy, Joseph. Circadian rhythms in the neuorbiology of bipolar disorder.

Degree: PhD, 2015, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/circadian-rhythms-in-the-neuorbiology-of-bipolar-of-bipolar-disorder(8d7f6f92-b7cd-4835-8e53-d15334c2dfe3).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644509

► Daily rhythms of physiology and behaviour in mammals are orchestrated by a hierarchical network of cellular oscillators. The master pacemaker that defines local and systemic… (more)

▼ Daily rhythms of physiology and behaviour in mammals are orchestrated by a hierarchical network of cellular oscillators. The master pacemaker that defines local and systemic timing across the brain and body are the suprachiasmatic nuclei of the hypothalamus (SCN). Disruption to the timing of sleep and daily behavioural activity can manifest in a range of pathologies including neuropsychiatric disorders. Bipolar disorder (BPD) is once such neurological condition that exhibits profound associations with altered circadian rhythm generation and whose toolkit of pharmacological interventions impact upon circadian rhythm generation. Currently it is unclear exactly how changes to rhythmic physiology contribute to the aetiology and pathology of BPD. In recent years, rodent models possessing lesions within genes that make up the basic cellular oscillator are widely reported to exhibit concomitant changes in affective behaviours, namely mania-like phenotypes. Recently a mouse model possessing a mutation within the neuron-specific Na+/K+-ATPase (NKA) alpha3 subunit, known as Myshkin, was described as a model of the manic phase of BPD. The NKA alpha3 is not reported as a critical element of the circadian oscillator and we used this opportunity to characterise the behavioural and physiological circadian system of these animals. Under wheel-running paradigms Myk/+ animals exhibited a broad array of behavioural deficits including lengthened, low amplitude and labile free-running rhythms, altered phase re-setting and elevated metabolic activity. Physiological characterisation of the SCN revealed deficits in amplitude of electrical output and changes to post-synaptic signalling although the ex vivo molecular pacemaking of the SCN remained intact. Myshkin animals therefore represent a novel model in which changes to central output arise independently of changes to basic molecular pacemaking. Despite this seemingly distinct mechanism Myshkin animals share many mood and circadian phenotypes with other clock gene models of affective behaviours highlighting that changes to pacemaking output of the SCN may be a critical factor across animal models exhibiting circadian and mood deficits. In addition, the impact of the mood stabiliser lithium, commonly prescribed in BPD, on cellular pathways within the SCN was investigated. Lithium consistently lengthens the period of cellular and behavioural rhythms in mammals although the mechanism of this action is yet undefined. Glycogen synthase kinase 3β (GSK3β) and inositol monophosphatase (IMPase) are the major biochemical targets of lithium at therapeutic concentrations. GSK3β is known to shorten rhythms and this study targeted IMPase and inositol phosphate turnover in the period lengthening effects of lithium. We reveal that although inhibition of IMPase dampens SCN molecular rhythms, the period of oscillations remains unchanged and therefore lithium acts upon distinct cellular pathways within the SCN to exert effects on period.

Subjects/Keywords: 616.89; Circadian; Bipolar Disorder; Lithium; Circadian Rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Timothy, J. (2015). Circadian rhythms in the neuorbiology of bipolar disorder. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/circadian-rhythms-in-the-neuorbiology-of-bipolar-of-bipolar-disorder(8d7f6f92-b7cd-4835-8e53-d15334c2dfe3).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644509

Chicago Manual of Style (16^th Edition):

Timothy, Joseph. “Circadian rhythms in the neuorbiology of bipolar disorder.” 2015. Doctoral Dissertation, University of Manchester. Accessed April 11, 2021. https://www.research.manchester.ac.uk/portal/en/theses/circadian-rhythms-in-the-neuorbiology-of-bipolar-of-bipolar-disorder(8d7f6f92-b7cd-4835-8e53-d15334c2dfe3).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644509.

MLA Handbook (7^th Edition):

Timothy, Joseph. “Circadian rhythms in the neuorbiology of bipolar disorder.” 2015. Web. 11 Apr 2021.

Vancouver:

Timothy J. Circadian rhythms in the neuorbiology of bipolar disorder. [Internet] [Doctoral dissertation]. University of Manchester; 2015. [cited 2021 Apr 11]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/circadian-rhythms-in-the-neuorbiology-of-bipolar-of-bipolar-disorder(8d7f6f92-b7cd-4835-8e53-d15334c2dfe3).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644509.

Council of Science Editors:

Timothy J. Circadian rhythms in the neuorbiology of bipolar disorder. [Doctoral Dissertation]. University of Manchester; 2015. Available from: https://www.research.manchester.ac.uk/portal/en/theses/circadian-rhythms-in-the-neuorbiology-of-bipolar-of-bipolar-disorder(8d7f6f92-b7cd-4835-8e53-d15334c2dfe3).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644509

3. Timothy, Joseph. Circadian rhythms in the neuorbiology of bipolar of bipolar disorder.

Degree: 2015, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:260119

► Daily rhythms of physiology and behaviour in mammals are orchestrated by a hierarchical network of cellular oscillators. The master pacemaker that defines local and systemic… (more)

▼ Daily rhythms of physiology and behaviour in mammals are orchestrated by a hierarchical network of cellular oscillators. The master pacemaker that defines local and systemic timing across the brain and body are the suprachiasmatic nuclei of the hypothalamus (SCN). Disruption to the timing of sleep and daily behavioural activity can manifest in a range of pathologies including neuropsychiatric disorders. Bipolar disorder (BPD) is once such neurological condition that exhibits profound associations with altered circadian rhythm generation and whose toolkit of pharmacological interventions impact upon circadian rhythm generation. Currently it is unclear exactly how changes to rhythmic physiology contribute to the aetiology and pathology of BPD. In recent years, rodent models possessing lesions within genes that make up the basic cellular oscillator are widely reported to exhibit concomitant changes in affective behaviours, namely mania-like phenotypes. Recently a mouse model possessing a mutation within the neuron-specific Na+/K+-ATPase (NKA) alpha3 subunit, known as Myshkin, was described as a model of the manic phase of BPD. The NKA alpha3 is not reported as a critical element of the circadian oscillator and we used this opportunity to characterise the behavioural and physiological circadian system of these animals. Under wheel-running paradigms Myk/+ animals exhibited a broad array of behavioural deficits including lengthened, low amplitude and labile free-running rhythms, altered phase re-setting and elevated metabolic activity. Physiological characterisation of the SCN revealed deficits in amplitude of electrical output and changes to post-synaptic signalling although the ex vivo molecular pacemaking of the SCN remained intact. Myshkin animals therefore represent a novel model in which changes to central output arise independently of changes to basic molecular pacemaking. Despite this seemingly distinct mechanism Myshkin animals share many mood and circadian phenotypes with other clock gene models of affective behaviours highlighting that changes to pacemaking output of the SCN may be a critical factor across animal models exhibiting circadian and mood deficits. In addition, the impact of the mood stabiliser lithium, commonly prescribed in BPD, on cellular pathways within the SCN was investigated. Lithium consistently lengthens the period of cellular and behavioural rhythms in mammals although the mechanism of this action is yet undefined. Glycogen synthase kinase 3β (GSK3β) and inositol monophosphatase (IMPase) are the major biochemical targets of lithium at therapeutic concentrations. GSK3β is known to shorten rhythms and this study targeted IMPase and inositol phosphate turnover in the period lengthening effects of lithium. We reveal that although inhibition of IMPase dampens SCN molecular rhythms, the period of oscillations remains unchanged and therefore lithium acts upon distinct cellular pathways within the SCN to exert effects on period. Advisors/Committee Members: BROOMHEAD, DAVID DS, MONTEMURRO, MARCELO M, Piggins, Hugh, Broomhead, David, Montemurro, Marcelo.

Subjects/Keywords: Circadian; Bipolar Disorder; Lithium; Circadian Rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Timothy, J. (2015). Circadian rhythms in the neuorbiology of bipolar of bipolar disorder. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:260119

Chicago Manual of Style (16^th Edition):

Timothy, Joseph. “Circadian rhythms in the neuorbiology of bipolar of bipolar disorder.” 2015. Doctoral Dissertation, University of Manchester. Accessed April 11, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:260119.

MLA Handbook (7^th Edition):

Timothy, Joseph. “Circadian rhythms in the neuorbiology of bipolar of bipolar disorder.” 2015. Web. 11 Apr 2021.

Vancouver:

Timothy J. Circadian rhythms in the neuorbiology of bipolar of bipolar disorder. [Internet] [Doctoral dissertation]. University of Manchester; 2015. [cited 2021 Apr 11]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:260119.

Council of Science Editors:

Timothy J. Circadian rhythms in the neuorbiology of bipolar of bipolar disorder. [Doctoral Dissertation]. University of Manchester; 2015. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:260119

Texas A&M University

4. Han, Yuyan. The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation.

Degree: PhD, Medical Sciences, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/154094

► Cholangiocarcinoma (CCA) is a devastating tumor characterized by late presentation of symptoms with limited treatment options. Disruption of circadian rhythm is associated with cancer development… (more)

▼ Cholangiocarcinoma (CCA) is a devastating tumor characterized by late presentation of symptoms with limited treatment options. Disruption of circadian rhythm is associated with cancer development and progression. MicroRNAs (miRNAs) are a class of small noncoding RNAs that trigger mRNA translation, repression or degradation. The aim of the study was to evaluate the role of deregulated circadian rhythm and related microRNAs in CCA growth. Human intra- and extrahepatic CCA cells and non-malignant (H69) human cholangiocytes were serum starved for 48 hours before stimulation with 50% serum for 2 hours. The 24-hours rhythmic expression of core clock genes, such as Per1/2/3, CLOCK, Bmal1, Cry1/2 and two clock-controlled genes (CCGs) WEE1 and DBP, was evaluated in the selected CCA cells and H69 controls by real-time PCR. To further evaluate the role of Per1, we overexpressed Per1 by transfecting Mz-ChA-1 CCA cells with Per1 or empty vector. In parallel studies, we silenced miR-34a expression with anti-miR-34a inhibitor. Then, we measured: (i) cell proliferation by MTS assays and PCNA immunoblots; (ii) cell cycle; (iii) apoptosis; and (iv) cell migration and. We used luciferase assay to demonstrate whether Per1 acts as a direct target of miR-34a. Finally, we maintained CCA xenograft nude mice in complete dark or light/dark cycle for up to 40 days before evaluating tumor growth. We found the 24-hours rhythmical expression of Per1 was abolished in all CCA cell lines. The rhythmic expression of Bmal1, CLOCK, Per2/3, Cry1/2, WEE1 and DBP was also lost in some of the CCA cell lines tested. After overexpression of Per1, Mz-ChA-1 showed: (i) reduced cell proliferation; (ii) higher G0/G1 arrest and lower G2/M arrest and (iii) enhanced apoptosis. miR-34a was rhythmically expressed in CCA cell lines and H69. Moreover, the inhibition of miR-34a decreased proliferation, migration and invasion in the selected CCA cell lines. Per1 was verified as a target of miR-34a. However, prolonged darkness therapy did not inhibit the CCA xenograft growth in vivo. Summary and conclusions: Disruption of circadian rhythms contributes to the malignant phenotypes of human CCA, and may serve as novel prognostic or therapeutic targets for CCA. Advisors/Committee Members: Alpini, Gianfranco (advisor), Meininger, Cynthia J. (committee member), Glaser, Shannon (committee member), Meng, Fanyin (committee member), Greene, John (committee member).

Subjects/Keywords: Circadian Rhythm; Cholangiocarcinoma; microRNA; Per1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Han, Y. (2014). The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/154094

Chicago Manual of Style (16^th Edition):

Han, Yuyan. “The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation.” 2014. Doctoral Dissertation, Texas A&M University. Accessed April 11, 2021. http://hdl.handle.net/1969.1/154094.

MLA Handbook (7^th Edition):

Han, Yuyan. “The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation.” 2014. Web. 11 Apr 2021.

Vancouver:

Han Y. The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1969.1/154094.

Council of Science Editors:

Han Y. The Effect of Disrupted Circadian Rhythm and Associated microRNA on Biliary Injury and Malignant Transformation. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/154094

University of Manchester

5. Otto, Sarah. The role of circadian rhythm in the immune response to Trichuris muris.

Degree: PhD, 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603124

► Circadian rhythms have been implicated in severity and outcome of infection and disease. Commonly, LPS and bacterial infection have been used to identify the mechanisms… (more)

▼ Circadian rhythms have been implicated in severity and outcome of infection and disease. Commonly, LPS and bacterial infection have been used to identify the mechanisms behind the difference in immune responses depending on the time of day of the challenge. In this thesis, the colon dwelling nematode parasite Trichuris muris, which elicits a Th2 immune response in resistant mice, was used to identify if circadian rhythms influence infection outcome 3 weeks post infection. C57BL/6 mice infected with 200 eggs of T. muris at ZT0 (7am, lights on) expelled the parasite more efficiently than mice infected at ZT12 (7pm, lights off), which expelled with a delay of several days compared to ZT0 infected mice. Analysis of cell infiltration into the colon during the first days of infection suggested that there was no visible difference in the local immune response. There also were no differences in macrophage and dendritic cell numbers in colon tissue of naïve mice at ZT0 or ZT12. Further experiments examined immunomodulation of the immune response to T. muris by pushing the immune response towards a Th1, by low dose infection, or a Th2 response, by vaccination with excretory/secretory antigen. In both cases any circadian influence was overwritten. Mice infected at ZT0 or ZT12 with only 40 eggs of T. muris were equally susceptible to infection and mice infected at ZT3 10 days after vaccination at ZT0 or ZT12 were equally resistant to infection. Mice food restricted to mid-light phase and infected at ZT0 were not significantly delayed in their worm expulsion or polarised more towards a Th1 immune response compared to ZT0 infected mice fed during the dark phase. Therefore it is unlikely that feeding behaviour during the first days of infection is able to polarise towards a Th1 response and lead to delayed worm expulsion. Transgenic mice were used to dissect the mechanism underlying the delay in worm expulsion in ZT12 infected mice. mPer2::luc mice were used to confirm rhythmic Per2 expression in colon tissue and dendritic cells. Infection of mPer2::luc mice at ZT0 or ZT12 with T. muris showed similar worm expulsion, antibody and cytokine production when infected at ZT0 or ZT12. Bmal1floxLysMcre mice, which lack rhythmic clock gene expression in macrophages and granulocytes, produced a stronger Th2 antibody response in a primary infection at ZT3 than wild-type littermate controls. Newly generated mPer2::lucBmal1floxCD11ccre mice showed the no difference in worm burden and parasite specific antibody production between ZT0 and ZT12 infected mice. Only IL-10 and IL-6 levels were significantly lower in ZT12 infected mPer2::LucBmal1floxCD11ccre mice compared to ZT12 infected wild-type littermates. Confirmation of removal of exon 8 of the Bmal1 gene was not achieved; therefore it is not clear if circadian rhythm in dendritic cells has any impact on the immune response to T. muris or if the mPer2::LucBmal1floxCD11ccre mice and littermate controls both contain circadian rhythm in dendritic cells and therefore cannot be used to identify the…

Subjects/Keywords: 616.07; Trichuris muris; Circadian rhythm

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APA (6^th Edition):

Otto, S. (2013). The role of circadian rhythm in the immune response to Trichuris muris. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603124

Chicago Manual of Style (16^th Edition):

Otto, Sarah. “The role of circadian rhythm in the immune response to Trichuris muris.” 2013. Doctoral Dissertation, University of Manchester. Accessed April 11, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603124.

MLA Handbook (7^th Edition):

Otto, Sarah. “The role of circadian rhythm in the immune response to Trichuris muris.” 2013. Web. 11 Apr 2021.

Vancouver:

Otto S. The role of circadian rhythm in the immune response to Trichuris muris. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Apr 11]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603124.

Council of Science Editors:

Otto S. The role of circadian rhythm in the immune response to Trichuris muris. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603124

6. Tokuyama, Takehito. Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある.

Degree: 博士(医学), 2014, Hiroshima University / 広島大学

URL: http://ir.lib.hiroshima-u.ac.jp/00040615

► Aims: Abnormal sympathetic innervation triggers ventricular fibrillation (VF). We examined the circadianvariation of autonomic nervous system and its relevance to risk stratification of VF in… (more)

Subjects/Keywords: Ventricular fibrillation; Circadian rhythm; Autonomic nervous system

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APA (6^th Edition):

Tokuyama, T. (2014). Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある. (Thesis). Hiroshima University / 広島大学. Retrieved from http://ir.lib.hiroshima-u.ac.jp/00040615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tokuyama, Takehito. “Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある.” 2014. Thesis, Hiroshima University / 広島大学. Accessed April 11, 2021. http://ir.lib.hiroshima-u.ac.jp/00040615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tokuyama, Takehito. “Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある.” 2014. Web. 11 Apr 2021.

Vancouver:

Tokuyama T. Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある. [Internet] [Thesis]. Hiroshima University / 広島大学; 2014. [cited 2021 Apr 11]. Available from: http://ir.lib.hiroshima-u.ac.jp/00040615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tokuyama T. Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation : ブルガダ症候群における心拍変動の日内変動の低下が心室細動発生機序に寄与している可能性がある. [Thesis]. Hiroshima University / 広島大学; 2014. Available from: http://ir.lib.hiroshima-u.ac.jp/00040615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

7. Morganti, Carol Jean Gruenewald. The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;.

Degree: MS;, Nursing;, 1983, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/957/rec/1365

► This study was an attempt to correlate biorhythm theory to outcomes of pregnancy, such as, labor onset, time of delivery, complications, and subjective experience. Sixty-nine… (more)

Subjects/Keywords: Nursing; Circadian Rhythm

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APA (6^th Edition):

Morganti, C. J. G. (1983). The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/957/rec/1365

Chicago Manual of Style (16^th Edition):

Morganti, Carol Jean Gruenewald. “The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;.” 1983. Masters Thesis, University of Utah. Accessed April 11, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/957/rec/1365.

MLA Handbook (7^th Edition):

Morganti, Carol Jean Gruenewald. “The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;.” 1983. Web. 11 Apr 2021.

Vancouver:

Morganti CJG. The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;. [Internet] [Masters thesis]. University of Utah; 1983. [cited 2021 Apr 11]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/957/rec/1365.

Council of Science Editors:

Morganti CJG. The effects of biorhythm cycles on labor onset, time of delivery and outcome of pregnancy;. [Masters Thesis]. University of Utah; 1983. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/957/rec/1365

8. Josephine, S. Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;.

Degree: 2014, Manonmaniam Sundaranar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/23345

►

The purpose of the study was to find out the effects of circadian rhythm on selected factors related to sports performance of sprinters and swimmers… (more)

Subjects/Keywords: Circadian Rhythm; Sports performance; Sprinters; swimmers; temperature

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APA (6^th Edition):

Josephine, S. (2014). Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/23345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Josephine, S. “Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;.” 2014. Thesis, Manonmaniam Sundaranar University. Accessed April 11, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/23345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Josephine, S. “Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;.” 2014. Web. 11 Apr 2021.

Vancouver:

Josephine S. Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2014. [cited 2021 Apr 11]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Josephine S. Effects of circadian rhythm on selected factors related to performance of swimmers and Sprinters;. [Thesis]. Manonmaniam Sundaranar University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

9. Dejong, Hannah. An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia.

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:239157

► The thesis presents a series of papers exploring catatonic symptoms and circadian rest-activity levels in autistic spectrum disorders (ASD). The thesis is presented in paper-based… (more)

Subjects/Keywords: autistic spectrum disorders; catatonia; actigraphy; circadian rhythm

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APA (6^th Edition):

Dejong, H. (2014). An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:239157

Chicago Manual of Style (16^th Edition):

Dejong, Hannah. “An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia.” 2014. Doctoral Dissertation, University of Manchester. Accessed April 11, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:239157.

MLA Handbook (7^th Edition):

Dejong, Hannah. “An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia.” 2014. Web. 11 Apr 2021.

Vancouver:

Dejong H. An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Apr 11]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:239157.

Council of Science Editors:

Dejong H. An investigation of circadian rest-activity levels in adolescents with autistic spectrum disorders, and a systematic review of treatments for autistic catatonia. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:239157

Texas A&M University

10. Huang, He. The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa.

Degree: MS, Biology, 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2885

► Circadian clocks are present in most eukaryotes and some prokaryotes and control rhythms in behavior, physiology and gene expression. One well-characterized circadian clock is that… (more)

Subjects/Keywords: circadian rhythm; neurospora

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APA (6^th Edition):

Huang, H. (2009). The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2885

Chicago Manual of Style (16^th Edition):

Huang, He. “The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa.” 2009. Masters Thesis, Texas A&M University. Accessed April 11, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2885.

MLA Handbook (7^th Edition):

Huang, He. “The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa.” 2009. Web. 11 Apr 2021.

Vancouver:

Huang H. The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa. [Internet] [Masters thesis]. Texas A&M University; 2009. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2885.

Council of Science Editors:

Huang H. The light mutant oscillator (LMO); a novel circadian oscillator in Neurospora crassa. [Masters Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2885

University of Texas Southwestern Medical Center

11. Spencer, Sade Monique. The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model.

Degree: 2012, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1006

► Mice with a mutation in the circadian gene Clock (Clockdelta19) display a behavioral profile which parallels a euphoric manic-like state including hyperactivity, disrupted activity rhythms,… (more)

▼ Mice with a mutation in the circadian gene Clock (Clockdelta19) display a behavioral profile which parallels a euphoric manic-like state including hyperactivity, disrupted activity rhythms, increased substance abuse vulnerability, and decreases in anxiety and depression-related behavior. The molecular clock has significant cross-talk with many of the brain’s neurotransmitter systems. The purpose of this dissertation is to characterize the role of CLOCK in regulating dopamine transmission in mood and reward-related circuits. We present a mechanism by which CLOCK regulates dopaminergic activity in the mesoaccumbens circuit and contributes to anxiety-related behavior. In vivo recording of ventral tegmental area (VTA) dopamine cells throughout the 24 hour cycle revealed that firing and bursting was elevated in Clockdelta19 mutants with the most significant deviations early in the light cycle. Mimicking this increase in dopaminergic activity using optogenetic targeting resulted in decreased anxiety-related behavior similar to the Clockdelta19 phenotype. Consistent with the electrophysiological findings, tyrosine hydroxylase (TH) mRNA and protein was elevated in the VTA in a daytime-specific manner leading to increased dopamine synthesis in the nucleus accumbens. CLOCK binding was detected at E-box elements within the TH promoter with greater enrichment observed during the light phase when TH expression is low. These results suggest a negative regulation of TH by CLOCK. To examine alterations in the nigrostriatal dopamine circuit, HPLC measurements of dopamine and metabolites were performed in the dorsal striatum revealing significant increases in DOPAC and HVA. Dopamine receptor agonists and antagonists were used to pharmacologically probe dopamine receptor function. An enhancement of the locomotor suppressing response to dopamine antagonists in Clockdelta19 mice suggested increased dopaminergic tone. Clockdelta19 mice were insensitive to the locomotor stimulating effects of a D1 agonist, but displayed increased levels of D1DR protein. Conversely, the Clockdelta19 mutants displayed enhanced locomotor suppression to a D2 agonist and a coincident increase in D2DR protein. Forskolin stimulation of cAMP resulted in blunted molecular responses in the Clockdelta19 mutants consistent with impairments in D1 signaling and/or enhancements in D2 signaling. In summary, normal CLOCK function appears to be involved in the regulation of dopamine transmission in the striatum. Advisors/Committee Members: McClung, Colleen A..

Subjects/Keywords: Circadian Rhythm; CLOCK Proteins; Bipolar Disorder; Dopamine

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APA (6^th Edition):

Spencer, S. M. (2012). The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spencer, Sade Monique. “The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model.” 2012. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/1006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spencer, Sade Monique. “The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model.” 2012. Web. 11 Apr 2021.

Vancouver:

Spencer SM. The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/1006.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spencer SM. The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model. [Thesis]. University of Texas Southwestern Medical Center; 2012. Available from: http://hdl.handle.net/2152.5/1006

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

12. Falcón-Morales, Edgardo. Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward.

Degree: 2012, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/995

► Disruptions in circadian rhythms are associated with neuropsychiatric disorders, including drug addiction. Indeed, mounting evidence reveals a role for the circadian clock in the regulation… (more)

▼ Disruptions in circadian rhythms are associated with neuropsychiatric disorders, including drug addiction. Indeed, mounting evidence reveals a role for the circadian clock in the regulation of drug reward and reward-related behaviors. Conversely, drugs of abuse are known to dysregulate circadian-associated processes and entrain locomotor behavior. The circadian clock is governed by a master pacemaker in the Suprachiasmatic Nucleus(SCN) of the anterior hypothalamus. However, the components of this circadian clock machinery are expressed throughout the brain and body, allowing for the occurrence of SCN-dependent or independent peripheral oscillators. One such brain circuit in which circadian genes are expressed is the mesolimbic dopaminergic pathway, containing brain regions such as the Nucleus Accumbens(NAc) and the Caudate Putamen (CP), among others. We set out to investigate how repeated cocaine exposure regulates core clock circadian genes in striatal regions and conversely, how core clock circadian genes regulate cocaine’s rewarding effects. Additionally, the potential regulation of rhythmic dopamine receptor expression directly by clock components and how their rhythmic expression is altered by repeated cocaine exposure was assessed. Chapter 3 determined circadian gene regulation in both the NAc and CP by cocaine. Not only did chronic cocaine upregulated a number of circadian genes at a specific timepoint, like Npas2 and the Per genes, but also altered or disrupted 24-hr rhythmic expression of these genes. Chapter 4 investigated the role of core circadian clock genes in cocaine reward, as measured by conditioned place preference. Npas2 mutant mice exhibited a decreased preference for cocaine, an effect that was recapitulated by viral-mediated Npas2 knockdown specifically in the NAc. Per mutant mice displayed an increase in cocaine preference. Knockdown of mPer1 and mPer2 in the NAc led to a trend towards increased preference. Chapter 5 identified a potential role for NPAS2 in the regulation of dopamine receptor rhythmic expression in the NAc, and that chronic cocaine disrupts this rhythmicity. These findings suggest an important role for Npas2 as mediator of cocaine responses in the NAc. Moreover, they further elucidate the bidirectional interactions between the circadian and reward systems, implicating the circadian control of the dopaminergic system in this interplay. Advisors/Committee Members: McClung, Colleen A..

Subjects/Keywords: Suprachiasmatic Nucleus; Circadian Rhythm; Substance-Related Disorders

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APA (6^th Edition):

Falcón-Morales, E. (2012). Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Falcón-Morales, Edgardo. “Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward.” 2012. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Falcón-Morales, Edgardo. “Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward.” 2012. Web. 11 Apr 2021.

Vancouver:

Falcón-Morales E. Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Falcón-Morales E. Regulation of Circadian Genes by Cocaine in Striatal Regions and Their Role in Drug Reward. [Thesis]. University of Texas Southwestern Medical Center; 2012. Available from: http://hdl.handle.net/2152.5/995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston

13. Burfield, Hannah. Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults.

Degree: MS, Physiological Optics and Vision Science, 2019, University of Houston

URL: http://hdl.handle.net/10657/4663

► Purpose: Evidence suggests that diurnal rhythms and light exposure patterns may influence the development of refractive error. This study investigated diurnal variations in anterior and… (more)

▼ Purpose: Evidence suggests that diurnal rhythms and light exposure patterns may influence the development of refractive error. This study investigated diurnal variations in anterior and posterior segment biometry and assessed differences between myopic and emmetropic adults. Ocular and systemic diurnal rhythms were also examined in relation to objectively measured light exposure and refractive error. Methods: Healthy subjects (n = 42, 23-41 years old) underwent biometry and spectral domain optical coherence tomography imaging (SD-OCT) every 4 hours (h) for 24 h. Subjects were in darkness from 11:00 pm to 7:00 am. Central corneal thickness, corneal power, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were measured. Thicknesses of the total retina, photoreceptor outer segments + retinal pigment epithelium (RPE), photoreceptor inner segments, and choroid for a 3mm and 6mm annulus were determined. Additional measurements taken at each time point included blood pressure, heart rate, body temperature, and intraocular pressure (IOP). Mean ocular perfusion pressure (MOPP) was calculated. Saliva was collected for melatonin and cortisol analysis. Subjects wore a light, sleep, and activity monitor for one week prior to measurements. Acrophase and amplitude for each parameter were compared between refractive error groups and relationship to light exposure was examined. Results: All ocular and systemic parameters except anterior chamber depth demonstrated significant diurnal variations. Amplitude of axial length variation (35.71 ± 19.40 μm) was in antiphase to choroid variation (25.65 ± 2.01 μm, P < 0.001). The central 1 mm retina underwent variation of 5.03 ± 0.23 μm with a peak at 12 h (p < 0.001), while photoreceptor outer segment + RPE thickness peaked at 4 h and inner segment thickness peaked at 16 h. Diurnal variations in retina and choroid were observed in the 3 and 6 mm annuli. Melatonin increased following light offset with a peak at 3.19 h, while cortisol peaked after light onset at 8.86 h. IOP peaked at 11.24 h, with a variation of 4.92 ± 1.57 of mmHg, in anti-phase with MOPP, which peaked at 22.02 h. No parameter demonstrated a difference in diurnal rhythm between refractive error groups except for body temperature and MOPP. Conclusion: Ocular and systemic diurnal rhythms were observed over 24 hours in adults. While differences in baseline parameters were found between refractive error groups, diurnal rhythms were not significantly different between myopes and emmetropes, except for body temperature and MOPP. Amplitudes of daily variations were not correlated with light exposure. Advisors/Committee Members: Ostrin, Lisa A. (advisor), Berntsen, David A. (committee member), Patel, Nimesh B. (committee member).

Subjects/Keywords: Myopia; Circadian rhythm; Choroid; Ocular biometry

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APA (6^th Edition):

Burfield, H. (2019). Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults. (Masters Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/4663

Chicago Manual of Style (16^th Edition):

Burfield, Hannah. “Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults.” 2019. Masters Thesis, University of Houston. Accessed April 11, 2021. http://hdl.handle.net/10657/4663.

MLA Handbook (7^th Edition):

Burfield, Hannah. “Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults.” 2019. Web. 11 Apr 2021.

Vancouver:

Burfield H. Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults. [Internet] [Masters thesis]. University of Houston; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10657/4663.

Council of Science Editors:

Burfield H. Ocular and Systemic Diurnal Rhythms in Emmetropic and Myopic Adults. [Masters Thesis]. University of Houston; 2019. Available from: http://hdl.handle.net/10657/4663

14. Ivy, Jessica Ruth. Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control.

Degree: PhD, 2016, University of Edinburgh

URL: http://hdl.handle.net/1842/22902

► Reabsorbing ~7% of the sodium load, the distal convoluted tubule plays key roles in blood pressure (BP) homeostasis. Here, Na-Cl co-transport (NCC) is the major… (more)

▼ Reabsorbing ~7% of the sodium load, the distal convoluted tubule plays key roles in blood pressure (BP) homeostasis. Here, Na-Cl co-transport (NCC) is the major route for apical Na entry making thiazide diuretics (NCC inhibitors) a mainstay hypertension treatment. Predictive adaptations of sodium excretory rhythms are supported by an intrinsic renal clock, which regulates transporter activity according to physiological need. Peripheral clocks can be influenced by glucocorticoids, which also have a circadian rhythm. We therefore hypothesized that NCC’s diurnal rhythm is regulated by glucocorticoids. C57BL6 mice were kept on a 12h light cycle with subjective day starting at 7am. Urine was collected in 12h periods and kidneys harvested at 1am (night) and 1pm (day). Slc12a3 (NCC encoding gene) mRNA and NCC protein abundance were similar between day and night but NCC phosphorylation at threonine 53 was significantly higher at night compared to day. Plasma and urinary corticosterone levels were elevated at night. Glucocorticoid inducible leucine zipper (GILZ) and serum and glucocorticoid inducible kinase (SGK1) transcripts also increased at night. Chronic corticosterone infusion flattened the plasma corticosterone rhythm within an intermediate physiological range. The diurnal rhythm of pT53 NCC was dampened in these mice but not in vehicle-treated mice. Blood pressure was monitored in the mice by radiotelemetry. After 2 weeks of baseline measurements mice received chronic corticosterone or vehicle for 3weeks, during the last 10 days of which they received ~80 mg/kg hydrochlorothiazide in their drinking water. At night systolic BP (SBP) was unaffected by any treatment whereas during the day SBP significantly increased following corticosterone but was unaffected by vehicle. Cosinor analysis of SBP in corticosterone and vehicle treated mice showed a marked reduction in rhythmicity, increased MESOR and reduced amplitude. In animals receiving corticosterone HCTZ partially rescued daytime SBP. This manoeuvre also improved SBP rhythmicity, reduced MESOR and increased amplitude. These data indicate that NCC phosphorylation has a diurnal rhythm that is in part regulated by glucocorticoids. They also show that alteration of the glucocorticoid rhythm affects the blood pressure rhythm in part through its effect on NCC phosphorylation. These findings may be clinically relevant in the pathogenesis of hypertension in conditions associated with elevated glucocorticoid levels such as metabolic syndrome and chronic stress.

Subjects/Keywords: 616.1; circadian rhythm; renal; hypertension; cardiovascular disease

11 more images…

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APA (6^th Edition):

Ivy, J. R. (2016). Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/22902

Chicago Manual of Style (16^th Edition):

Ivy, Jessica Ruth. “Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control.” 2016. Doctoral Dissertation, University of Edinburgh. Accessed April 11, 2021. http://hdl.handle.net/1842/22902.

MLA Handbook (7^th Edition):

Ivy, Jessica Ruth. “Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control.” 2016. Web. 11 Apr 2021.

Vancouver:

Ivy JR. Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control. [Internet] [Doctoral dissertation]. University of Edinburgh; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1842/22902.

Council of Science Editors:

Ivy JR. Glucocorticoids and the diurnal rhythm of NCC phosphorylation : implications for blood pressure control. [Doctoral Dissertation]. University of Edinburgh; 2016. Available from: http://hdl.handle.net/1842/22902

University of Washington

15. Speed, Andrea. Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing.

Degree: 2016, University of Washington

URL: http://hdl.handle.net/1773/35085

► Given that seniors today are more active, living longer, and have a wider variety of needs, the composition of a senior living residence should likewise… (more)

Subjects/Keywords: circadian rhythm; housing; neurogenesis; senior; Architecture; architecture

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APA (6^th Edition):

Speed, A. (2016). Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/35085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Speed, Andrea. “Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing.” 2016. Thesis, University of Washington. Accessed April 11, 2021. http://hdl.handle.net/1773/35085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Speed, Andrea. “Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing.” 2016. Web. 11 Apr 2021.

Vancouver:

Speed A. Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing. [Internet] [Thesis]. University of Washington; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1773/35085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Speed A. Neural Networks and Neighborhood Inclusion: A Paradigm Shift in Senior Housing. [Thesis]. University of Washington; 2016. Available from: http://hdl.handle.net/1773/35085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

16. Liang, Xue. Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota.

Degree: 2015, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/1845

► Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, antipyretic, and anti-inflammatory effects. However, NSAIDs commonly induce gastrointestinal toxicity by mechanisms that are incompletely… (more)

▼ Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, antipyretic, and anti-inflammatory effects. However, NSAIDs commonly induce gastrointestinal toxicity by mechanisms that are incompletely understood, and the efficacy and side effects of these drugs exhibit significant inter-individual variability, which is partially explained by pharmacogenetics. The vertebrate intestinal microbiota have a highly diverse enzymatic system and hence have been implicated in the metabolism of various xenobiotics, including clinically important drugs. The composition of intestinal microbiota exhibits considerable inter-individual differences, and dysbiosis has been associated with the pathogenesis of many diseases. The present study is designed to elucidate the interactions between the microbiota and indomethacin, an NSAID that inhibits cyclooxygenases (COX) -1 and 2. At a dose that caused small intestinal damage, orally administered indomethacin was distributed in the circulation and in the intestinal tract, and suppressed the production of both COX-1 and COX-2 derived prostaglandins in vivo. Deep sequencing analysis showed that indomethacin altered the composition and diversity of the large intestinal and fecal microbiota, shifting it towards a pro-inflammatory phenotype. Depletion of the intestinal microbiota by antibiotic treatment increased indomethacin elimination, and decreased its half-life and volume of distribution. This involves the de-glucuronidation mediated by the β-glucuronidase-expressing bacteria in the intestinal microbiota. Therefore, the intestinal microbiota may be a potential source of inter-individual variability in the pharmacokinetics and/or pharmacodynamics of indomethacin. This study also found that the total fecal microbial load, as well as the relative abundances of Bacteroidetes and Firmicutes oscillated during the light-dark cycle. This oscillation requires a functional host circadian clock, since deletion of Bmal1, a gene encoding a core molecular clock component, abolished this rhythmicity. The fecal microbiota composition was also altered by Bmal1-deletion. In addition, the relative abundances of several β-glucuronidase-expressing bacteria oscillate diurnally, suggesting the involvement of intestinal microbiota in the chronopharmacology of indomethacin. The indomethacin-microbiota interactions described here provide candidate mechanisms for pathogenesis of GI toxicity, individualized drug responses, as well as the circadian variation of drug kinetics and effects.

Subjects/Keywords: circadian rhythm; indomethacin; intestinal microbiota; pharmacokinetics; Pharmacology

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APA (6^th Edition):

Liang, X. (2015). Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/1845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liang, Xue. “Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota.” 2015. Thesis, University of Pennsylvania. Accessed April 11, 2021. https://repository.upenn.edu/edissertations/1845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liang, Xue. “Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota.” 2015. Web. 11 Apr 2021.

Vancouver:

Liang X. Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota. [Internet] [Thesis]. University of Pennsylvania; 2015. [cited 2021 Apr 11]. Available from: https://repository.upenn.edu/edissertations/1845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liang X. Bidirectional Interactions Between Indomethacin and the Murine intestinal Microbiota. [Thesis]. University of Pennsylvania; 2015. Available from: https://repository.upenn.edu/edissertations/1845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

York University

17. Firoozi, Ghazaleh. Characterization of PRD-1 Mutation in Neurospora crassa.

Degree: MSc -MS, Biology, 2014, York University

URL: http://hdl.handle.net/10315/27621

► In Neurospora crassa, rhythmic conidiation is controlled by several oscillators such as FRQ/WCC and FLO. The frequency (frq) gene and white collar genes (WC-1 and… (more)

Subjects/Keywords: Biology; Prd-1 gene; Circadian rhythm; Neurospora

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APA (6^th Edition):

Firoozi, G. (2014). Characterization of PRD-1 Mutation in Neurospora crassa. (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/27621

Chicago Manual of Style (16^th Edition):

Firoozi, Ghazaleh. “Characterization of PRD-1 Mutation in Neurospora crassa.” 2014. Masters Thesis, York University. Accessed April 11, 2021. http://hdl.handle.net/10315/27621.

MLA Handbook (7^th Edition):

Firoozi, Ghazaleh. “Characterization of PRD-1 Mutation in Neurospora crassa.” 2014. Web. 11 Apr 2021.

Vancouver:

Firoozi G. Characterization of PRD-1 Mutation in Neurospora crassa. [Internet] [Masters thesis]. York University; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10315/27621.

Council of Science Editors:

Firoozi G. Characterization of PRD-1 Mutation in Neurospora crassa. [Masters Thesis]. York University; 2014. Available from: http://hdl.handle.net/10315/27621

University of Texas Southwestern Medical Center

18. Lee, Ivan T. Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/4106

► Behavioral circadian rhythms in mammals are controlled by highly heterogeneous populations of neurons located in the suprachiasmatic nucleus (SCN). Lesion and transplantation studies have established… (more)

▼ Behavioral circadian rhythms in mammals are controlled by highly heterogeneous populations of neurons located in the suprachiasmatic nucleus (SCN). Lesion and transplantation studies have established that the SCN is both necessary and sufficient for the generation of daily rhythms in locomotion. It remains uncertain, however, whether this pacemaking property of the SCN is limited to certain subsets of cells or intrinsic to all neurons within the SCN. To dissect out the cellular properties of circadian rhythms, we utilized a BAC transgenic mouse line in which Cre recombinase (iCre) is driven by the promoter of neuromedin S (Nms), a neuropeptide that has restricted expression in ~40% of cells within the SCN. Using this cell-type specific driver, we genetically altered the molecular oscillation of Nms-positive cells by overexpressing the ClockΔ19 or the Period2 transgene. ClockΔ19 is a semi-dominant mutation that leads to lengthened behavioral circadian periods when expressed in the majority of SCN cells. Likewise, Period2, when overexpressed in all or almost all of the SCN neurons, lead to the loss of behavioral circadian rhythms. We found that, intriguingly, the transgenic expression of ClockΔ19 only in Nms-positive neurons leads to a lengthened period in circadian rhythms while the overexpression of Per2 in Nms-expressing neurons causes the loss of daily rhythms altogether, suggesting that behavioral rhythms can be controlled by the molecular oscillation of Nms-positive cells. Next, to ascertain whether Nms-expressing neurons are required for normal behavioral circadian rhythms, we utilized a tetanus toxin-based technology that permits the inducible and reversible inhibition of neurotransmission. Surprisingly, this genetic manipulation revealed that synaptic neurotransmission from Nms neurons is essential for the generation of behavioral circadian rhythms. Taken together, these results indicate that Nms marks a specialized subgroup of neurons that is both necessary and sufficient for the production of circadian rhythms in behavior. Advisors/Committee Members: Elmquist, Joel, Russell, David W., Greene, Robert W., Yanagisawa, Masashi, Takahashi, Joseph.

Subjects/Keywords: Circadian Clocks; Circadian Rhythm; Neurons; Neuropeptides; Suprachiasmatic Nucleus

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APA (6^th Edition):

Lee, I. T. (2013). Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/4106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Ivan T. “Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/4106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Ivan T. “Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus.” 2013. Web. 11 Apr 2021.

Vancouver:

Lee IT. Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/4106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee IT. Cellular Basis of Behavioral Circadian Rhythms in Mammals: The Role of Neuromedin S (Nms)-Producing Cells in the Suprachiasmatic Nucleus. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/4106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

19. Dixon, Laura Evelyn. Investigation of light inputs into plant circadian clocks.

Degree: PhD, 2011, University of Edinburgh

URL: http://hdl.handle.net/1842/5266

► Circadian clocks are biological signalling networks which have a period of ~24 hours under constant environmental conditions. They have been identified in a wide range… (more)

▼ Circadian clocks are biological signalling networks which have a period of ~24 hours under constant environmental conditions. They have been identified in a wide range of organisms, from cyanobacteria to mammals and through the temporal co-ordination of biological processes are believed to increase individual fitness. The mechanisms which generate these self-sustained rhythms, the pathways of entrainment and the target outputs of the clock are all areas of great interest to circadian biologists. The plant circadian clock is believed to comprise of interlocking feedback loops of transcription and translation. The morning MYB-transcription factors CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) bind to the promoter of TIMING OF CAB2 1 (TOC1) and repress its expression, as well as their own. As levels of CCA1 and LHY fall, TOC1 is expressed and activates the expression of its repressors. This is a simplified version of the known clock components and the current model contains this core loop as well as an interlocked morning and evening loop, which also incorporates some post-translational modification (Chapter 1). Understanding the plant circadian network and its entrainment are the topics of this thesis. The study has focused on two plant species, the land plant Arabidopsis thaliana and the picoeukaryotic marine algae Ostreococcus tauri. In both of these species light-mediated entrainment of the clock has been investigated (Chapter 8), as well as the core circadian mechanism. In A. thaliana the role of a circadian associated gene, EARLY FLOWERING 3 has been a particular focus for investigation, through both experimentation and mathematical models (Chapters 4 and 5). In O. tauri the responses to light signals have been tested, as have the circadian responses to pharmacological manipulation (Chapters 6, 7 and 8). The work presented identifies a role for ELF3 in the repression of circadian genes and also links it with the regulation of protein stability. Likewise, in O. tauri the regulation of protein stability is identified to be a key mechanism for sustaining circadian rhythms. As well as investigating the clock in plants, certain photoreceptors have been characterised in S. cerevisiae with the aim of linking them to a synthetic oscillator. Together the work presented in this thesis provides evidence for the circadian community to aid with the understanding of circadian rhythms in plants, and possibly other organisms.

Subjects/Keywords: 571.2; circadian rhythm; circadian clock; TOC1; light-mediated entrainment; ELF3

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APA (6^th Edition):

Dixon, L. E. (2011). Investigation of light inputs into plant circadian clocks. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/5266

Chicago Manual of Style (16^th Edition):

Dixon, Laura Evelyn. “Investigation of light inputs into plant circadian clocks.” 2011. Doctoral Dissertation, University of Edinburgh. Accessed April 11, 2021. http://hdl.handle.net/1842/5266.

MLA Handbook (7^th Edition):

Dixon, Laura Evelyn. “Investigation of light inputs into plant circadian clocks.” 2011. Web. 11 Apr 2021.

Vancouver:

Dixon LE. Investigation of light inputs into plant circadian clocks. [Internet] [Doctoral dissertation]. University of Edinburgh; 2011. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1842/5266.

Council of Science Editors:

Dixon LE. Investigation of light inputs into plant circadian clocks. [Doctoral Dissertation]. University of Edinburgh; 2011. Available from: http://hdl.handle.net/1842/5266

East Tennessee State University

20. Crain, Shae. Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock.

Degree: MS, Biology, 2019, East Tennessee State University

URL: https://dc.etsu.edu/etd/3673

► This study examines locomotor activity in samples of Frontinella pyramitela collected over its active season (April-October) to investigate whether seasonality and/or age may help… (more)

Subjects/Keywords: circadian rhythm; seasonality; behavioral rhythm; aging; clock; spiders; Biology

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APA (6^th Edition):

Crain, S. (2019). Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock. (Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/3673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crain, Shae. “Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock.” 2019. Thesis, East Tennessee State University. Accessed April 11, 2021. https://dc.etsu.edu/etd/3673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crain, Shae. “Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock.” 2019. Web. 11 Apr 2021.

Vancouver:

Crain S. Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock. [Internet] [Thesis]. East Tennessee State University; 2019. [cited 2021 Apr 11]. Available from: https://dc.etsu.edu/etd/3673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crain S. Age and Seasonal Change in the Chronobiology of a Spider with an Exceptionally Long-Period Circadian Clock. [Thesis]. East Tennessee State University; 2019. Available from: https://dc.etsu.edu/etd/3673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

21. Salfer, Isaac. NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE.

Degree: 2019, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/16717ijs5089

► Dairy cows exhibit well-characterized daily patterns of feed intake and milk synthesis. These patterns may represent circadian rhythms, endogenous repeating cycles of approximately 24 h… (more)

▼ Dairy cows exhibit well-characterized daily patterns of feed intake and milk synthesis. These patterns may represent circadian rhythms, endogenous repeating cycles of approximately 24 h that govern most physiological processes. Circadian rhythms are controlled by a set of ‘clock’ transcription factors that oscillate over 24 h and govern gene expression across the day. There is an increasing body of evidence demonstrating a role of nutrient intake in modifying circadian rhythms in peripheral tissues. However, this effect has not been well-characterized in dairy cattle. In addition to a daily rhythms of milk synthesis, dairy cows display seasonal changes of milk production that are not well understood. The objective of this dissertation was to examine the factors affecting daily and annual rhythms of milk synthesis. Specifically, we wanted to examine the effects of nutrient intake on the daily rhythms of milk synthesis, and the relationships between cow-level and environmental factors and the annual rhythms of milk production. To accomplish these objectives, 6 experiments were conducted, with the first 4 examining the role of nutrient intake on the daily rhythms of milk synthesis, and the final 2 characterizing factors influencing annual rhythms of milk production. First, the effect of time-restricted feeding on the daily patterns of milk synthesis and plasma hormones and metabolites was examined in an experiment where feed was temporally restricted to cows for 16 h/d either during the day (0700 to 2300 h) or at night (1900 to 1100 h). This experiment demonstrated that night restricted feeding shifted the peak of milk yield from morning to evening, while shifting the peak of milk fat and protein concentration from evening to morning. Moreover, the daily rhythms of plasma glucose, nonesterified fatty acids, plasma urea nitrogen, and insulin were shifted about 8 h by night-restricted feeding. The objective of the second experiment was to investigate if the changes in daily patterns of milk synthesis during time-restricted feeding were caused by changes in the molecular circadian clock of the mammary gland. This experiment compared a control group with feed available continuously to cows under night-restricted feeding (feed available for 16 h/d from 2000 h to 1200 h). Results demonstrated that night-restricted feeding altered the daily rhythms of expression of clock genes circadian locomoter output cycles kaput, cryptochrome 1 and REV-ERBα, suggesting that nutrients entrain the molecular circadian clock of the mammary gland. The final two experiments examined the role of specific nutrients on the daily rhythms of milk synthesis. In one experiment, a high C18:1 oil was abomasally infused either 24 h/d or for 8 h during the day (0900 to 1700 h) or the night (from 2100 to 0500). Day-infusion increased the amplitudes of milk and milk fat and protein yield while reducing the amplitudes of milk fat and protein concentration. However, treatment had little influence on the phase of the rhythms, suggesting that the timing of fatty… Advisors/Committee Members: Kevin John Harvatine, Dissertation Advisor/Co-Advisor, Kevin John Harvatine, Committee Chair/Co-Chair, Paul Allen Bartell, Committee Member, William Burton Staniar, Committee Member, Connie Jo Rogers, Outside Member.

Subjects/Keywords: Biological rhythm; milk synthesis; daily rhythm; annual rhythm; circadian; dairy cattle; food entrainment

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APA (6^th Edition):

Salfer, I. (2019). NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/16717ijs5089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salfer, Isaac. “NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE.” 2019. Thesis, Penn State University. Accessed April 11, 2021. https://submit-etda.libraries.psu.edu/catalog/16717ijs5089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salfer, Isaac. “NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE.” 2019. Web. 11 Apr 2021.

Vancouver:

Salfer I. NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE. [Internet] [Thesis]. Penn State University; 2019. [cited 2021 Apr 11]. Available from: https://submit-etda.libraries.psu.edu/catalog/16717ijs5089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salfer I. NUTRITIONAL AND ENVIRONMENTAL FACTORS REGULATING BIOLOGICAL RHYTHMS OF MILK SYNTHESIS IN DAIRY CATTLE. [Thesis]. Penn State University; 2019. Available from: https://submit-etda.libraries.psu.edu/catalog/16717ijs5089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Sarout, Bruna Nunes Marsiglio. Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth.

Degree: 2017, Brazil

URL: http://hdl.handle.net/10183/164375

►

As tecnologias baseadas em sensores estão cada vez mais disponíveis e podem ser usadas para coletar informações detalhadas sobre o comportamento animal. Com esta informação… (more)

▼

As tecnologias baseadas em sensores estão cada vez mais disponíveis e podem ser usadas para coletar informações detalhadas sobre o comportamento animal. Com esta informação é possível avaliar o ritmo circadiano de variáveis comportamentais e monitorar sua resposta. A identificação de variações na resposta deste ritmo tem o potencial de detectar problemas de saúde e questões de bem-estar animal. O objetivo deste trabalho foi estudar os ritmos circadianos comportamentais como uma nova abordagem para monitorar ovelhas em sistemas extensivos e estudar a emissão de metano, eficiência alimentar e crescimento de novilhos de corte. Este trabalho foi composto por dois experimentos (ovinos e bovinos). Foram utilizados cochos automatizados e sensores de atividade baseados em acelerômetro para coletar informações detalhadas do comportamento ingestivo (bovinos) e do comportamento de atividade (ovinos e bovinos), juntamente com as características de desempenho animal. Estes dados foram utilizados para calcular a percentagem de comportamento cíclico harmônico/sincronizado a cada período de 24 h. Essa porcentagem é chamada de grau de acoplamento funcional (DFC) e é calculada com uso de um período móvel de sete dias. No experimento com ovinos, um total de 29 ovelhas Scottish Blackface foram monitoradas por quatro semanas em cada estação do ano, em sistema extensivo nas terras altas da Escócia. Dados meteorológicos foram coletados diariamente. Modelos estatísticos de regressão com efeito aleatório foram utilizados para avaliar a variação da resposta entre indivíduos. Houve uma forte dinâmica criada pelas estações do ano e pelo ciclo produtivo/fisiológico das ovelhas. Durante a primavera e o verão, o desvio padrão do DFC foi um melhor estimador do ganho de peso quando comparado ao índice de moção. A combinação da análise do DFC e o agrupamento de indivíduos com base em sua resposta às variáveis ambientais oferece potencial para obter informações relevantes para o manejo do rebanho. O experimento de bovinos foi conduzido com duas dietas contrastantes (volumoso: concentrado 8:92 e 50:50) e duas raças (40 mestiços Charolês e 40 Luing). Os padrões diurnos de ingestão e atividade foram altamente sincronizados. O ritmo circadiano da atividade foi importante para explicar as diferentes emissões de metano entre indivíduos, independente da raça ou dieta, e também teve ligação com a eficiência alimentar e o crescimento dos novilhos. Este trabalho mostra a importância dos ritmos circadianos comportamentais e como essas abordagens podem melhorar a qualidade e o significado dos dados provenientes de sensores automatizados.

Sensor-based technologies are becoming increasingly available and can be used to gather detailed information about animal behaviour. With this information it is possible to assess animal behavioural circadian rhythm and monitor its response. Identifying breakdowns of this rhythm has the potential to detect health problems and animal welfare issues. The aim of this work was to study the behavioural circadian rhythms as a novel…

Advisors/Committee Members: Poli, Cesar Henrique Espirito Candal.

Subjects/Keywords: Ovelha; Bovino; Comportamento animal; Comportamento ingestivo; Metano; Animal behaviour; Circadian rhythm; Circadian rhythm; Methane emission; Phenotypic plasticity; Precision livestock farming; Sensors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sarout, B. N. M. (2017). Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth. (Doctoral Dissertation). Brazil. Retrieved from http://hdl.handle.net/10183/164375

Chicago Manual of Style (16^th Edition):

Sarout, Bruna Nunes Marsiglio. “Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth.” 2017. Doctoral Dissertation, Brazil. Accessed April 11, 2021. http://hdl.handle.net/10183/164375.

MLA Handbook (7^th Edition):

Sarout, Bruna Nunes Marsiglio. “Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth.” 2017. Web. 11 Apr 2021.

Vancouver:

Sarout BNM. Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth. [Internet] [Doctoral dissertation]. Brazil; 2017. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10183/164375.

Council of Science Editors:

Sarout BNM. Behavioural circadian rhythms : a novel approach to monitor sheep in extensive systems and study the differences between beef steers for methane emission, feed efficiency and growth. [Doctoral Dissertation]. Brazil; 2017. Available from: http://hdl.handle.net/10183/164375

Vanderbilt University

23. Wenzler, Marta Elise. Progress Toward the Total Synthesis of Upenamide.

Degree: PhD, Chemistry, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/15332

► Upenamide is a marine alkaloid natural product isolated in 2000 from the marine sponge Echinochalina sp. Protolithospongia. Spectral analysis of the marine alkaloid by the… (more)

Subjects/Keywords: Formal [4+2] Addition; Diels-Alder Cycloaddition; Upenamide; Phenazine; Circadian Clock; Staudinger Cyclization; Circadian Rhythm

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APA (6^th Edition):

Wenzler, M. E. (2015). Progress Toward the Total Synthesis of Upenamide. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15332

Chicago Manual of Style (16^th Edition):

Wenzler, Marta Elise. “Progress Toward the Total Synthesis of Upenamide.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed April 11, 2021. http://hdl.handle.net/1803/15332.

MLA Handbook (7^th Edition):

Wenzler, Marta Elise. “Progress Toward the Total Synthesis of Upenamide.” 2015. Web. 11 Apr 2021.

Vancouver:

Wenzler ME. Progress Toward the Total Synthesis of Upenamide. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1803/15332.

Council of Science Editors:

Wenzler ME. Progress Toward the Total Synthesis of Upenamide. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/15332

24. Zhang, Yuan. Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein.

Degree: Docteur es, Immunologie, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLS422

► BMAL1, une protéine centrale de l'horloge circadienne.L’inactivation de BMAL1 (BMAL1-KO) entraîne une perte complète de la rythmicité dans les horloges central et périphérique. Le travail… (more)

▼ BMAL1, une protéine centrale de l'horloge circadienne.L’inactivation de BMAL1 (BMAL1-KO) entraîne une perte complète de la rythmicité dans les horloges central et périphérique. Le travail de ma thèse se concentre sur le rôle du gène BMAL1 dans la développement et le traitement des cancers du sein et du côlon.1. Pharmacodynamique in vitro de l’Everolimus en fonction du temps d’administration malgré une horloge circadienne défectueuse ((Zhang et al., 2018) (Zhang, Levi and Chang, 2018)L’everolimus (EV) est un inhibiteur de la mTOR chez les mammifères et il est utilisé pour traiter le cancer du sein positif aux oestrogènes (ER+). Nous avons focalisé nos recherches sur la chronopharmacologie de l’Everolimus administré sur des cellules MCF-7 (ER+). Les MCF-7 présentent une oscillation circadienne de l’activité de mTOR sans mise en évidence d’une oscillation des gènes d’horloge. L’oscillation d’activité de mTOR induirait une oscillation de synthèse et/ou de phosphorylation de protéines importantes dans la progression de la phase G1, notamment la Cycline D1 et RB phosphorylée. Ces variations rythmiques des MCF-7 synchronisées expliquent la chrono-efficacité de l’Everolimus selon des temps différents d’administration.Ce travail a révélé que même dans un système de cellules cancéreuses dont l’horloge était perturbée, l'intégration d'autres rythmes cellulaires dans la chronothérapie pouvait augmenter l'efficacité du médicament. Ce principe peut être appliqué à des traitements du cancer pour optimiser la chronothérapie du cancer.2. Le Knockdown BMAL1 a déclenché différents destins de cellules du carcinome du côlon (CRC) en modifiant l'équilibre délicat entre les voies AKT / mTOR et P21 / P53 (Article soumis)Premièrement, nos résultats ont révélé que le knockdown BMAL1 par le shRNA (BMAL1-KD) avait déclenché une activation plus évidente de l’AKT / mTOR dans deux lignées cellulaires primaires (HCT116 et SW480) que une lignée métastatique de CRC, SW620. De plus, bien que les deux lignées cellulaires primaires de CRC aient présenté une augmentation significative de l'activité de l'AKT/mTOR, elles avaient des statuts différents de P53 (WT ou mutant). Dans ce contexte, les cellules SW480 BMAL1-KD avec P53 mutant présentaient une sénescence accrue, mais les cellules HCT116 BMAL1-KD avec P53 WT présentaient d’abord une apoptose transitoire, puis un taux de prolifération plus élevé.Ainsi, nos travaux ont révélé le rôle crucial de BMAL1 pour équilibrer un régulateur central du métabolisme AKT / mTOR et une voie de réponse au stress P53 / P21 dans des lignées cellulaires de CRC, ce qui met en évidence l’importance de BMAL1 dans le développement de CRC et la progression du vieillissement.3. BMAL1 renforce les propriétés épithéliales et diminue la chimiorésistance des cellules du CRC (article en préparation)La transition épithélo-mésenchymateuse (EMT) est un événement critique dans l'invasion et la métastase des carcinomes, y compris le CRC.Dans ce travail, nous avons étudié comment BMAL1 knockdown (Bmal1-KD) altère l’équilibre délicat… Advisors/Committee Members: Chang, Yunhua (thesis director), Dulong, Sandrine (thesis director).

Subjects/Keywords: Rythme circadien; Gènes circadiens; Bmal1; Carcinome; Chronothérapie; Circadian Rhythm; Circadian Genes; Bmal1; Carcinoma; Chronotherapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, Y. (2019). Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS422

Chicago Manual of Style (16^th Edition):

Zhang, Yuan. “Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed April 11, 2021. http://www.theses.fr/2019SACLS422.

MLA Handbook (7^th Edition):

Zhang, Yuan. “Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein.” 2019. Web. 11 Apr 2021.

Vancouver:

Zhang Y. Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Apr 11]. Available from: http://www.theses.fr/2019SACLS422.

Council of Science Editors:

Zhang Y. Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment : L’horloge circadienne et le cancer : L'implication de BMAL1 dans le développement et le traitement du carcinome colorectal et du sein. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS422

University of Texas Southwestern Medical Center

25. Fu, Jingjing. Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function.

Degree: 2018, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/8798

► Most amino acids are encoded by two to six synonymous genetic codons. Synonymous codons are not used with the same frequency in all organisms, and… (more)

▼ Most amino acids are encoded by two to six synonymous genetic codons. Synonymous codons are not used with the same frequency in all organisms, and every organism has its own preferred codon usage bias. Codon usage bias has been shown to positively correlate with tRNA abundance, thus optimal codons are thought to be translated more efficiently and accurately. Consistent with this, strong codon usage biases have been shown to be important for the expression of highly expressed genes in different organisms, and codon optimization has been widely used to enhance heterologous protein expression. Therefore, codon usage can be an important determinant in gene expression. In addition, codon usage has been shown to influence translation elongation rate and protein structure by affecting the co-translational folding process in E. coli, fungi, and insects. In addition to its role in regulating protein translation, codon usage also has a major role in determining the level of gene expression through transcriptional and post-transcriptional processes. As such, gene codon usage has been proposed to be a code within the genetic code that can determine both gene expression levels and protein structures and therefore activity. However, the effects of codon usage in multi-tissue organisms, for example, animals and humans, are not clear. In the first part of the thesis, by codon-optimizing open reading frame of Drosophila period gene, I showed that dper codon usage is critical for its circadian clock function. Optimization of dper codon usage resulted in conformational changes of dPER protein, altered dPER phosphorylation profile and stability, and impaired dPER repressor function in the circadian negative feedback loop. In the second part of the thesis, I reported that changing rare codons to common in KRAS increased translation and mRNA levels. Regulation of mRNA levels is a major mechanism affecting KRAS levels, but the effect was not a product of mRNA stability, but instead transcriptional. Moreover, codon usage also had an impact on the structure of KRAS. Thus, the rare codon bias of KRAS effects more aspects of protein production and function than previously appreciated, which has important implications for other rare codon enriched mammalian genes. Advisors/Committee Members: Jiang, Jin, Liu, Yi, Cobb, Melanie H., Green, Carla B..

Subjects/Keywords: Circadian Rhythm; Codon Usage; Drosophila; Period Circadian Proteins; Proto-Oncogene Proteins p21(ras)

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APA (6^th Edition):

Fu, J. (2018). Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/8798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fu, Jingjing. “Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function.” 2018. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/8798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fu, Jingjing. “Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function.” 2018. Web. 11 Apr 2021.

Vancouver:

Fu J. Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2018. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/8798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fu J. Code Within Codes: Codon Usage Regulate Protein Expression, Structure, and Function. [Thesis]. University of Texas Southwestern Medical Center; 2018. Available from: http://hdl.handle.net/2152.5/8798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

26. Marković, Vladimir M., 1985-. Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola.

Degree: Fakultet za fizičku hemiju, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:7450/bdef:Content/get

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Fizička hemija - biofizička hemija i dinamika neravnotežnih procesa / Physical chemistry - Biophysical chemistry and dynamics of non-equilibrium processes

Hipotalamo-hipofizno-adrenalna (eng. hypothalamic-pituitary-adrenal, HPA) osa… (more)

▼

Fizička hemija - biofizička hemija i dinamika neravnotežnih procesa / Physical chemistry - Biophysical chemistry and dynamics of non-equilibrium processes

Hipotalamo-hipofizno-adrenalna (eng. hypothalamic-pituitary-adrenal, HPA) osa predstavlja složen neuroendokrini sistem koji učestvuje u održavanju optimalnog dinamičkog stanja živog sistema (homeostaze). Bilo da je u osnovnom (bazalnom) ili nekom pobuđenom stanju pod dejstvom stresa, takav složeni nelinearni sistem je uvek daleko od termodinamičke ravnoteže i poseduje povratnu spregu. Zato hormone koji ga čine nalazimo u različitim dinamičkim stanjima. U osnovnom stanju, tzv. bazalnoj fiziologiji, koncentracija hormona kortizola, krajnjeg produkta i glavnog efektornog hormona HPA sistema čoveka, ispoljava složenu oscilatornu evoluciju u vremenu, sa unutardnevnim (ultradijalnim) oscilacijama superponiranim na dnevne (cirkadijalne) oscilacije. Na osnovu sve većeg broja dokaza postalo je očigledno da je odgovarajuća oscilatorna dinamika HPA sistema nepohodan preduslov za normalno funkcionosanje i zdravlje organizma, s obzirom na to da su promene u dinamičkom ponašanju HPA sistema povezane sa mnogim metaboličkim i psihijatrijskim poremećajima. Stoga je potrebno sveobuhvatnije ispitivanje dinamičkih svojstava HPA ose, koje obuhvata ne samo eksperimentalne studije, već i modeliranje i predviđanje na bazi numeričkih simulacija. U tom cilju je u skorije vreme razvijen priličan broj matematičkih modela koji mogu da simuliraju različite dinamičke karakteristike HPA ose u njenim osnovnim kao i u patološkim stanjima. Modeliranje mehanizma procesa na bazi stehiometrijskih relacija između reakcionih vrsta, i osnovnih principa nelinerane dinamike se pokazalo kao koristan pristup u simuliranju različitih složenih dinamičkih stanja koji se javljaju u mnogim sistemima, uključujući oscilatorno ponašanje HPA sistema. Glavni cilj ove doktorske disertacije je modeliranje dinamičkih stanja HPA sistema čoveka i koncentracije kortizola kao reprezentativnog hormona za prikazivanje tih stanja, koja se mogu javiti pod različitim fiziološkim uslovima ili usled delovanja perturbatora HPA sistema, kao što su akutni i hronični stres. Taj cilj je postignut upotrebom stehiometrijskog modela aktivnosti HPA ose, formulisanog od strane Jelić i saradnika (2005) kao polazne osnove. U ovoj tezi, navedeni model je postepeno razvijan unapređivanjem i usklađivanjem njegovog mehanizma sa poznatim in vivo eksperimentalnim podacima. U toku istraživanja je pokazano da ovakvo modeliranje na bazi stehiometrijskih relacija između vrsta poseduje značajan potencijal za proučavanje kompleksnih nelinearnih reakcionih procesa koji se nalaze u stanjima udaljenim od termodinamičke ravnoteže, kao što su procesi koji se odigravaju u neuroendokrinom HPA sistemu...

Advisors/Committee Members: Kolar-Anić, Ljiljana, 1947-.

Subjects/Keywords: HPA; SNA; oscillatory states; ultradian rhythm; circadian rhythm; cortisol; cholesterol; stress; nonlinear dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marković, Vladimir M., 1. (2015). Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:7450/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marković, Vladimir M., 1985-. “Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola.” 2015. Thesis, Univerzitet u Beogradu. Accessed April 11, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:7450/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marković, Vladimir M., 1985-. “Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola.” 2015. Web. 11 Apr 2021.

Vancouver:

Marković, Vladimir M. 1. Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2021 Apr 11]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7450/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marković, Vladimir M. 1. Modeliranje dinamičkih stanja hipotalamo-hipofizno-adrenalnog sistema i koncentracije kortizola. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7450/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

York University

27. Saroiu, Tudor. A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera).

Degree: MSc -MS, Biology, 2014, York University

URL: http://hdl.handle.net/10315/27612

► Circadian clocks are central to physiology. In animals, clocks are distributed in cells and tissues throughout the organism. The specific role of these clocks in… (more)

Subjects/Keywords: Biology; Endocrinology; Physiology; Slave oscillator; Fat body; Circadian rhythm; PER; Clock; Ecdysteroids; Endocrine rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saroiu, T. (2014). A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera). (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/27612

Chicago Manual of Style (16^th Edition):

Saroiu, Tudor. “A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera).” 2014. Masters Thesis, York University. Accessed April 11, 2021. http://hdl.handle.net/10315/27612.

MLA Handbook (7^th Edition):

Saroiu, Tudor. “A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera).” 2014. Web. 11 Apr 2021.

Vancouver:

Saroiu T. A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera). [Internet] [Masters thesis]. York University; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10315/27612.

Council of Science Editors:

Saroiu T. A Steroid Driven Peripheral Oscillator in Fat Body Cells of Rhodnius prolixus (Hemiptera). [Masters Thesis]. York University; 2014. Available from: http://hdl.handle.net/10315/27612

Louisiana State University

28. Chiragh, Imran. Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein.

Degree: MSChE, Chemical Engineering, 2011, Louisiana State University

URL: etd-04282011-152449 ; https://digitalcommons.lsu.edu/gradschool_theses/530

► Biological rhythms control many temporal behaviors of organism, such as the sleep cycle, hearts rhythms, seasonal animal migrations etc. Understanding these rhythms would provide insight… (more)

▼ Biological rhythms control many temporal behaviors of organism, such as the sleep cycle, hearts rhythms, seasonal animal migrations etc. Understanding these rhythms would provide insight into the temporal process of living organisms. Saccharomyces cerevisiae, a budding yeast, is an ideal model organism to study biological rhythms in eukaryotic cells because of its sequenced genome and discerned processes. By characterizing the biological rhythm in budding yeast, insight can be gained into more complex organisms. Previous studies have exhibited oscillatory behavior of oxygen consumption and determined that deletion of the GTS1 gene dissipates this rhythm. However, to further understand the specific behavior of this gene, GTS1 needs to be simultaneous monitored as it is expressed. In this study to monitor this ultradian rhythm regulating gene, a promoter-reporter construct was inserted through homologous recombination to track the expression of GTS1 in a diploid yeast strain, BY 4743. The promoter-reporter construct replaced one copy of the GTS1. As the GTS1 was expressed, the construct was expressed and detected by its reporter gene, green fluorescent protein (GFP). Synchronization of the cell cycle and ultradian rhythm was achieved by addition of hydroxyurea and nocodazole to the growth media. GFP levels were quantified by flow cytometry, with samples taken every 10 minutes. The results showed GFP expression level from the transformed yeast strain exhibiting a 3.33-fold increase relative to the non-transformed yeast strain. GFP expression yielded a biological rhythm with two identifiable periods, each with a 70 minute period. The first oscillation began at time zero and had a GFP expression maximum of 2.96 times the control level and a minimum of 2.62. The second oscillation began at 70 minutes had a GFP expression maximum of 3.09 times the control and a minimum of 2.76. The biological rhythm observed was shorter than its own cell cycle, roughly 111 minutes. Oscillatory behavior was observed as long as the culture remained synchronous. This study characterized the behavior of GTS1, an ultradian rhythm gene. By characterizing the behavior of this gene in S. cerevisiae, homologous genes in more complex organisms such as rodents or humans can be better understood. By extrapolating temporal behavior in yeast to humans, a cost effective drug prescreening can be implemented to evaluate possible biological rhythmic changes.

Subjects/Keywords: ultradian rhythm; saccharomyces cerevisiae; reporter gene; green fluorescent protein; yeast; budding yeast; circadian rhythm; biological rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chiragh, I. (2011). Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein. (Masters Thesis). Louisiana State University. Retrieved from etd-04282011-152449 ; https://digitalcommons.lsu.edu/gradschool_theses/530

Chicago Manual of Style (16^th Edition):

Chiragh, Imran. “Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein.” 2011. Masters Thesis, Louisiana State University. Accessed April 11, 2021. etd-04282011-152449 ; https://digitalcommons.lsu.edu/gradschool_theses/530.

MLA Handbook (7^th Edition):

Chiragh, Imran. “Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein.” 2011. Web. 11 Apr 2021.

Vancouver:

Chiragh I. Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein. [Internet] [Masters thesis]. Louisiana State University; 2011. [cited 2021 Apr 11]. Available from: etd-04282011-152449 ; https://digitalcommons.lsu.edu/gradschool_theses/530.

Council of Science Editors:

Chiragh I. Developing a tool to characterize the ultradian rhythm in diploid Saccharomyces cervisiae using the reporter gene green fluorescent protein. [Masters Thesis]. Louisiana State University; 2011. Available from: etd-04282011-152449 ; https://digitalcommons.lsu.edu/gradschool_theses/530

29. Beal, Douglas. A validation study of the short assessment of morningness-eveningness in an HIV-affected population.

Degree: MS, 1994, Oregon Health Sciences University

URL: doi:10.6083/M4DV1H4J ; http://digitalcommons.ohsu.edu/etd/2814

Subjects/Keywords: Acquired Immunodeficiency Syndrome; Circadian Rhythm

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Beal, D. (1994). A validation study of the short assessment of morningness-eveningness in an HIV-affected population. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4DV1H4J ; http://digitalcommons.ohsu.edu/etd/2814

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Beal, Douglas. “A validation study of the short assessment of morningness-eveningness in an HIV-affected population.” 1994. Thesis, Oregon Health Sciences University. Accessed April 11, 2021. doi:10.6083/M4DV1H4J ; http://digitalcommons.ohsu.edu/etd/2814.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Beal, Douglas. “A validation study of the short assessment of morningness-eveningness in an HIV-affected population.” 1994. Web. 11 Apr 2021.

Vancouver:

Beal D. A validation study of the short assessment of morningness-eveningness in an HIV-affected population. [Internet] [Thesis]. Oregon Health Sciences University; 1994. [cited 2021 Apr 11]. Available from: doi:10.6083/M4DV1H4J ; http://digitalcommons.ohsu.edu/etd/2814.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beal D. A validation study of the short assessment of morningness-eveningness in an HIV-affected population. [Thesis]. Oregon Health Sciences University; 1994. Available from: doi:10.6083/M4DV1H4J ; http://digitalcommons.ohsu.edu/etd/2814

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Horneck, Victoria J. A Validation study of the short assessment of morningness-eveningness.

Degree: MS, 1992, Oregon Health Sciences University

URL: doi:10.6083/M44T6GGP ; http://digitalcommons.ohsu.edu/etd/1748

Subjects/Keywords: Wakefulness; Circadian Rhythm; Sleep

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Horneck, V. J. (1992). A Validation study of the short assessment of morningness-eveningness. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M44T6GGP ; http://digitalcommons.ohsu.edu/etd/1748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Horneck, Victoria J. “A Validation study of the short assessment of morningness-eveningness.” 1992. Thesis, Oregon Health Sciences University. Accessed April 11, 2021. doi:10.6083/M44T6GGP ; http://digitalcommons.ohsu.edu/etd/1748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Horneck, Victoria J. “A Validation study of the short assessment of morningness-eveningness.” 1992. Web. 11 Apr 2021.

Vancouver:

Horneck VJ. A Validation study of the short assessment of morningness-eveningness. [Internet] [Thesis]. Oregon Health Sciences University; 1992. [cited 2021 Apr 11]. Available from: doi:10.6083/M44T6GGP ; http://digitalcommons.ohsu.edu/etd/1748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Horneck VJ. A Validation study of the short assessment of morningness-eveningness. [Thesis]. Oregon Health Sciences University; 1992. Available from: doi:10.6083/M44T6GGP ; http://digitalcommons.ohsu.edu/etd/1748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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