subject:(Chronic Kidney Disease)

Mississippi State University

1. Grant, Joshua. The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification.

Degree: MS, Agricultural and Biological Engineering, 2015, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;

► Cardiovascular disease is most deadly medical condition in the United States. Medial vascular calcification is a disease that often precedes other more serious cardiovascular… (more)

Subjects/Keywords: Chronic Kidney Disease; Osteogenic Differentiation

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APA (6^th Edition):

Grant, J. (2015). The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;

Chicago Manual of Style (16^th Edition):

Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification.” 2015. Masters Thesis, Mississippi State University. Accessed April 17, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.

MLA Handbook (7^th Edition):

Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification.” 2015. Web. 17 Apr 2021.

Vancouver:

Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification. [Internet] [Masters thesis]. Mississippi State University; 2015. [cited 2021 Apr 17]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.

Council of Science Editors:

Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on in vitro calcification. [Masters Thesis]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;

2. Alderson, Helen. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086

► Chronic Kidney Disease (CKD) is common and is associated with increased risk of progression to end stage renal disease, cardiovascular disease and death. CKD is… (more)

▼ Chronic Kidney Disease (CKD) is common and is associated with increased risk of progression to end stage renal disease, cardiovascular disease and death. CKD is a heterogeneous condition and accurately predicting an individual’s risk for adverse outcomes remains a challenge. Over the past decade there has been a focus on the identification of novel biomarkers that may help improve risk stratification and the prediction of clinical endpoints in this population.The overall aim of this research project was to investigate a series of novel biomarkers in patients from the Chronic Renal Insufficiency Standards Implementation Study (CRISIS), a prospective observational study of outcome in all cause non-dialysis dependent CKD 3-5. The biomarkers selected for this project were Anti-Apolipoprotein A-1 (Anti-apoA-1 IgG), fetuin-A, fibroblast growth factor-23 (FGF23), high sensitivity cardiac troponin T (HS-cTnT), kidney injury molecule-1 (KIM-1), N-terminal pro-brain natriuretic peptide (NT-proBNP), neutrophil gelatinase associated lipocalin (NGAL) and osteoprotegerin (OPG). These biomarkers were chosen to address the three clinical endpoints of progression, cardiovascular disease and death with biomarkers considered both individually and as groups of related markers.The first aim of this project was to examine associations between the novel biomarkers and the clinical characteristics of the CRISIS population. The second aim was to investigate the associations between novel biomarkers and the study endpoints. In the case of FGF23 longitudinal measurements were analysed and in all other cases associations between baseline levels of the markers and clinical outcomes were considered. The third aim was to consider whether the biomarkers investigated in this project actually improve parameters of risk stratification and model discrimination, thereby demonstrating a potential to improve the prediction of outcome events in the CKD population.Many of the biomarkers were independently associated with one or all of the clinical outcomes considered. Despite these associations, it was more difficult to demonstrate clear improvement in risk classification or the prediction of clinical endpoints. Baseline models of standard biochemical and clinical parameters performed very well so even biomarkers that were strongly associated with clinical outcomes resulted in only small incremental improvements in the prediction of outcome events. It is now important to focus on defining how biomarkers may fit into clinical decision pathways. Advisors/Committee Members: MIDDLETON, RACHEL RJ, Kalra, Philip, Middleton, Rachel.

Subjects/Keywords: Biomarkers; Chronic Kidney Disease; Outcomes

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APA (6^th Edition):

Alderson, H. (2017). Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086

Chicago Manual of Style (16^th Edition):

Alderson, Helen. “Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.” 2017. Doctoral Dissertation, University of Manchester. Accessed April 17, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086.

MLA Handbook (7^th Edition):

Alderson, Helen. “Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.” 2017. Web. 17 Apr 2021.

Vancouver:

Alderson H. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Apr 17]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086.

Council of Science Editors:

Alderson H. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086

Queens University

3. McCabe, Kristin. The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease .

Degree: Pharmacology and Toxicology, 2015, Queens University

URL: http://hdl.handle.net/1974/12694

► Chronic kidney disease (CKD) affects approximately 3 million Canadians and these patients have a markedly increased risk of developing cardiovascular disease. CKD patients have abnormal… (more)

▼ Chronic kidney disease (CKD) affects approximately 3 million Canadians and these patients have a markedly increased risk of developing cardiovascular disease. CKD patients have abnormal mineral metabolism and vitamin K status; dysfunctions that can accelerate the rate of vascular calcification. Matrix Gla protein (MGP) is a key tissue based inhibitor of calcification and is dependent on vitamin K for activity. In this thesis, an adenine-induced rat model of CKD was used to characterize quantitatively and temporally the impact of changing vitamin K status on the susceptibility of vessels to calcification. Treatment with the vitamin K antagonist warfarin, at therapeutic levels, significantly increased vessel calcification and the attendant circulatory consequences (higher pulse pressure and pulse wave velocity) whereas treatment with dietary vitamin K attenuated the pathogenesis. Vitamin K (K1) treatment increased the tissue levels of both forms of vitamin K (K1 and MK-4) in all the tissues studied. Vitamin K metabolism was clearly altered by CKD, in that there was a shift to lower K1 and higher MK-4 tissue content, resulting in an increased MK-4:K1 ratio. Although somewhat paradoxical, a decrease in the expression level of the MK-4 synthesizing enzyme UBIAD1 and the vitamin K recycling enzyme VKOR was found. This latter finding suggests that increased MK-4 was not due to an increase in production but rather to a decrease in utilization of MK-4. Patients with CKD are also known to be deficient in calcitriol. In this thesis the impact of two doses of calcitriol (20 ng/kg and 80 ng/kg), in the presence of low or high vitamin K status, on CKD-induced vascular calcification was assessed. Both calcitriol doses increased the severity of calcification regardless of vitamin K status. That is, contrary to the hypothesis, high dietary vitamin K1 was unable to attenuate the pro-calcification stimulus of calcitriol, and furthermore, warfarin treatment did not worsen it. The basis for these unanticipated findings points to the obese phenotype of the animals used potentially masking the potential benefits of calcitriol treatments, although this concept requires further study. Although several unexpected findings occurred, this thesis still fills some key gaps in knowledge pertaining to the role of vitamin K status in the development of vascular calcification during CKD and as a therapeutic intervention.

Subjects/Keywords: Chronic Kidney Disease ; Vascular Calcification

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APA (6^th Edition):

McCabe, K. (2015). The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCabe, Kristin. “The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease .” 2015. Thesis, Queens University. Accessed April 17, 2021. http://hdl.handle.net/1974/12694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCabe, Kristin. “The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease .” 2015. Web. 17 Apr 2021.

Vancouver:

McCabe K. The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease . [Internet] [Thesis]. Queens University; 2015. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1974/12694.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCabe K. The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease . [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/12694

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

4. Seyed Shobeiri, Navid. The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments .

Degree: Pharmacology and Toxicology, 2013, Queens University

URL: http://hdl.handle.net/1974/8498

► Vascular calcification (VC) is accelerated in patients with chronic kidney disease (CKD), resulting in increased risk of cardiovascular disease and mortality. Although the consequences of… (more)

▼ Vascular calcification (VC) is accelerated in patients with chronic kidney disease (CKD), resulting in increased risk of cardiovascular disease and mortality. Although the consequences of VC are associated with elevated pulse wave velocity (PWV) and left ventricular hypertrophy (LVH), the temporal impact on blood pressure changes is unknown. Mineral imbalance in CKD greatly contributes to the development of VC, and elevated serum phosphate is a major risk factor. Magnesium, which plays an important role in bone regulation, has been recently shown to be a modifier of VC, but whether magnesium inhibits calcification in CKD is unknown. A modified adenine model of CKD was developed in rats, characterized by mineral imbalance and progressive VC. During the development of VC, pulse pressure increased, which was driven by a drop in diastolic blood pressure, rather than systolic hypertension. Continuous pressure recordings in conscious rats using radiotelemetry revealed a significant increase in systolic variability associated with development of VC. Regional VC was associated with regional changes in the hemodynamic profile of the CKD rats. For example, only thoracic aortic calcification was associated with elevated PWV and pulse pressure. In contrast, the presence of abdominal and thoracic calcification differentially affected proximal and distal arterial pressure wave forms. CKD animals exhibited LVH, which was further increased by the presence of VC. In addition, fibroblast growth factor 23, which regulates renal excretion of phosphate, was elevated in CKD animals at every time point and was associated with LVH independently from VC. Development of VC was characterized in an in vitro organ model. Phosphate elevation in vitro caused VC in aortas. In vitro, magnesium supplementation inhibited initiation and progression of VC. CKD animals given a magnesium diet also demonstrated attenuated development of VC. In patients with stage 3-5 CKD (excluding dialysis), dietary phosphate was associated with the progression of coronary artery calcification even after adjusting for use of phosphate binders, total dietary energy and total dietary protein. Given the serious negative outcomes associated with development of VC, these findings fill key gaps in knowledge regarding the detection, management, prevention and treatment of VC in CKD.

Subjects/Keywords: Vascular Calcification ; Chronic Kidney Disease

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APA (6^th Edition):

Seyed Shobeiri, N. (2013). The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8498

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seyed Shobeiri, Navid. “The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments .” 2013. Thesis, Queens University. Accessed April 17, 2021. http://hdl.handle.net/1974/8498.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seyed Shobeiri, Navid. “The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments .” 2013. Web. 17 Apr 2021.

Vancouver:

Seyed Shobeiri N. The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments . [Internet] [Thesis]. Queens University; 2013. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1974/8498.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seyed Shobeiri N. The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments . [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8498

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

5. Cobrin, Allison. Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2013, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534

► Canine chronic kidney disease (CKD) is estimated to have a prevalence of 0.5-7%, and improved methods for the detection and monitoring of CKD are needed.… (more)

Subjects/Keywords: biomarkers; canine; chronic kidney disease

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APA (6^th Edition):

Cobrin, A. (2013). Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534

Chicago Manual of Style (16^th Edition):

Cobrin, Allison. “Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease.” 2013. Doctoral Dissertation, University of Guelph. Accessed April 17, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534.

MLA Handbook (7^th Edition):

Cobrin, Allison. “Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease.” 2013. Web. 17 Apr 2021.

Vancouver:

Cobrin A. Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease. [Internet] [Doctoral dissertation]. University of Guelph; 2013. [cited 2021 Apr 17]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534.

Council of Science Editors:

Cobrin A. Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease. [Doctoral Dissertation]. University of Guelph; 2013. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534

University of California – San Francisco

6. Low, Erik. In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.

Degree: Oral and Craniofacial Sciences, 2015, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/3rb9d6wp

► Purpose: The aim of this study is to investigate, in a population of patients with compromised renal function, is there a correlation in periodontal status… (more)

Subjects/Keywords: Dentistry; Chronic kidney disease; Periodontics

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APA (6^th Edition):

Low, E. (2015). In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/3rb9d6wp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Low, Erik. “In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.” 2015. Thesis, University of California – San Francisco. Accessed April 17, 2021. http://www.escholarship.org/uc/item/3rb9d6wp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Low, Erik. “In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.” 2015. Web. 17 Apr 2021.

Vancouver:

Low E. In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2021 Apr 17]. Available from: http://www.escholarship.org/uc/item/3rb9d6wp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Low E. In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/3rb9d6wp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

7. Hannan, Mary. Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.

Degree: 2019, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23705

► Introduction: Chronic kidney disease (CKD) is a common disease in older adults that is associated with numerous complications, including cognitive impairment and vascular dysfunction. Additionally,… (more)

▼ Introduction: Chronic kidney disease (CKD) is a common disease in older adults that is associated with numerous complications, including cognitive impairment and vascular dysfunction. Additionally, older adults have lifestyle factors that can negatively influence their health, including being sedentary. The purpose of this dissertation was to examine cognitive function, physical inactivity levels, and vascular function in older adults with and without CKD and to explore the relationships between these factors. Additionally, the relationship between cognitive function and vascular compliance and whether level of physical inactivity moderated this relationship was explored. Methods: Utilizing a cross-sectional design, 48 older adults (24 with CKD, 24 without CKD) were evaluated for performance on a cognitive test of global cognition and executive function, vascular compliance via tonometry and ultrasound (carotid compliance and endothelial function), and physical inactivity with actigraphy. Data was analyzed utilizing OLS regression, Pearson’s correlations, and regression moderation analysis. Results: Older adults with CKD had different levels of cognitive impairment, vascular dysfunction, and physical inactivity than older adults without CKD. In regression models including CKD and relevant covariates, the variance of cognitive function, indicators of regional arterial stiffness, some indicators of carotid compliance, and sedentary time per day were significantly explained. With exploration, global cognitive function was found to be significantly correlated with carotid-femoral pulse wave velocity and an indicator of carotid artery compliance. Executive function scores were not found to be significantly correlated with vascular compliance in older adults with CKD. There was exploration into the potential moderating influence of sedentary time on the relationship between vascular compliance and cognitive function in older adults. Conclusion: Cognitive impairment, some indicators of vascular function, and sedentary time appear to be different between older adults with and without CKD. With exploration, there was support of a potential relationship between vascular compliance and global cognitive function. Further investigation is needed into the moderating influence of sedentary time on the relationship between vascular function and cognitive impairment. There is a need for further exploration into the relationships between cognitive function, physical inactivity levels, and vascular function in older adults with and without CKD. Advisors/Committee Members: Bronas, Ulf G (advisor), Collins, Eileen G (committee member), Phillips, Shane A (committee member), Quinn, Lauretta (committee member), Steffen, Alana (committee member), Bronas, Ulf G (chair).

Subjects/Keywords: Chronic kidney disease; Cognitive function

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APA (6^th Edition):

Hannan, M. (2019). Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hannan, Mary. “Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.” 2019. Thesis, University of Illinois – Chicago. Accessed April 17, 2021. http://hdl.handle.net/10027/23705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hannan, Mary. “Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.” 2019. Web. 17 Apr 2021.

Vancouver:

Hannan M. Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/10027/23705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hannan M. Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. [Thesis]. University of Illinois – Chicago; 2019. Available from: http://hdl.handle.net/10027/23705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kansas State University

8. Vaske, Heather. Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet.

Degree: MS, Department of Clinical Sciences, 2015, Kansas State University

URL: http://hdl.handle.net/2097/35273

► Hyperthyroidism is the most common endocrinopathy of geriatric cats and has physiologic effects on almost every organ in the body. It specifically affects the kidneys… (more)

Subjects/Keywords: Hyperthyroidism; Chronic kidney disease

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APA (6^th Edition):

Vaske, H. (2015). Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/35273

Chicago Manual of Style (16^th Edition):

Vaske, Heather. “Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet.” 2015. Masters Thesis, Kansas State University. Accessed April 17, 2021. http://hdl.handle.net/2097/35273.

MLA Handbook (7^th Edition):

Vaske, Heather. “Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet.” 2015. Web. 17 Apr 2021.

Vancouver:

Vaske H. Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet. [Internet] [Masters thesis]. Kansas State University; 2015. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/2097/35273.

Council of Science Editors:

Vaske H. Assessment of renal function in hyperthyroid cats managed with a controlled iodine diet. [Masters Thesis]. Kansas State University; 2015. Available from: http://hdl.handle.net/2097/35273

University of Minnesota

9. Leither, Maxwell. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.

Degree: MS, Clinical Research, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/198958

► Introduction: Limited data exist regarding outcomes of patients with outpatient acute kidney injury (AKI). To determine whether outpatient AKI is associated with increased mortality and… (more)

Subjects/Keywords: acute kidney injury; chronic kidney disease; nephrology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leither, M. (2017). Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198958

Chicago Manual of Style (16^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Masters Thesis, University of Minnesota. Accessed April 17, 2021. http://hdl.handle.net/11299/198958.

MLA Handbook (7^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Web. 17 Apr 2021.

Vancouver:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Internet] [Masters thesis]. University of Minnesota; 2017. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/11299/198958.

Council of Science Editors:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Masters Thesis]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/198958

University of Edinburgh

10. MacIntyre, Iain McGregor. Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/10032

► Chronic kidney disease (CKD) is an important independent risk factor in the development of cardiovascular disease (CVD). Indeed, patients with CKD are far more likely… (more)

▼ Chronic kidney disease (CKD) is an important independent risk factor in the development of cardiovascular disease (CVD). Indeed, patients with CKD are far more likely to die from CVD than reach end stage renal disease. Conventional cardiovascular risk factors and co-morbidity contribute to this increased risk of CVD. However, emerging evidence suggests other novel factors including inflammation, oxidative stress, and a shift in the balance of the vasodilator nitric oxide and vasoconstrictor endothelin system, are also important contributors. Despite increasing evidence that the endothelin system plays an important role in the development of CKD and CVD, there has been little research examining possible therapeutic benefits of its modification in patients with CKD. The overall aims of the work presented within this thesis were to examine CVD risk in patients with renal impairment and then to see what impact chronic inhibition of the endothelin system would have on risk factors for CVD and CKD progression. In the first two studies I examined markers of arterial stiffness (AS) and endothelial function in a cohort of patients with immune-mediated renal disease. I was able to show in the acute setting that improvement in renal function following treatment for these conditions leads to significant improvements in AS. Interestingly, in patients who were in remission from their renal disease, only classical cardiovascular risk factors appear to be linked to AS. In the next study I was able to prove that sitaxsentan, a selective oral ETA antagonist, did not cause functional blockade of the ETB receptor in man. This was the first study of its kind to confirm that a “selective” endothelin antagonist truly is selective in vivo: a finding that will allow more accurate mechanistic investigation of the ET system. In the final studies, I showed that in subjects with stable non-diabetic proteinuric CKD, chronic selective ETA receptor antagonism reduces blood pressure and AS, and that these systemic benefits are associated with an increase in renal blood flow and reduction in proteinuria. The reduction in proteinuria is most likely haemodynamic and linked to a fall in GFR and filtration fraction, similar to what is seen with ACE inhibitors. Importantly, these benefits were seen in patients already taking maximally tolerated renin-angiotensin aldosterone system blockade, suggesting that chronic endothelin antagonism could be an important future therapy in the management of CKD. In summary, I have shown that renal impairment can directly affect markers of arterial function and by inference increase the risk of CVD. Chronic antagonism of the endothelin system with ETA receptor blockers would appear to improve many of these biomarkers, including reductions in BP, AS and proteinuria. There were no adverse effects reported in these studies, suggesting that selective ETA antagonism may be safe enough for clinical development in CKD patients. Further larger clinical trials are warranted.

Subjects/Keywords: 616.6; endothelin; chronic kidney disease; cardiovascular disease

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APA (6^th Edition):

MacIntyre, I. M. (2014). Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/10032

Chicago Manual of Style (16^th Edition):

MacIntyre, Iain McGregor. “Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed April 17, 2021. http://hdl.handle.net/1842/10032.

MLA Handbook (7^th Edition):

MacIntyre, Iain McGregor. “Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.” 2014. Web. 17 Apr 2021.

Vancouver:

MacIntyre IM. Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1842/10032.

Council of Science Editors:

MacIntyre IM. Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/10032

University of Newcastle

11. Boudville, Neil. Outcomes following living kidney donation.

Degree: 2018, University of Newcastle

URL: http://hdl.handle.net/1959.13/1385432

►

Higher Doctorate - Doctor of Medicine (DMed)

The research that forms the content of this thesis has been performed over the last 14 years and… (more)

Subjects/Keywords: chronic kidney disease; kidney transplantation; living kidney transplantation; living donor

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APA (6^th Edition):

Boudville, N. (2018). Outcomes following living kidney donation. (Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1385432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boudville, Neil. “Outcomes following living kidney donation.” 2018. Thesis, University of Newcastle. Accessed April 17, 2021. http://hdl.handle.net/1959.13/1385432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boudville, Neil. “Outcomes following living kidney donation.” 2018. Web. 17 Apr 2021.

Vancouver:

Boudville N. Outcomes following living kidney donation. [Internet] [Thesis]. University of Newcastle; 2018. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1959.13/1385432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boudville N. Outcomes following living kidney donation. [Thesis]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1385432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

12. Tracey De-Yi, Ying. Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches .

Degree: 2019, University of Sydney

URL: http://hdl.handle.net/2123/20927

► Background: Clinicians face considerable uncertainty in the management of common complications related to kidney transplantation including cardiovascular disease, cancer and rejection. A well-designed randomised controlled… (more)

▼ Background: Clinicians face considerable uncertainty in the management of common complications related to kidney transplantation including cardiovascular disease, cancer and rejection. A well-designed randomised controlled trial (RCT) is the ideal study type to help answer questions in areas of clinical equipoise. The deficiencies of nephrology RCTs are well known to the nephrology community. Together with the known issues of logistics, cost and lack of infrastructure, kidney transplantation trials face unique challenges that impact study design, trial feasibility and ascertainment of trial outcomes. Given current failure to improve long-term outcomes for kidney transplant recipients, there is a need to enhance trial design and feasibility by making trials more efficient and more focussed on what matters to patients and clinicians. Methods: This thesis utilises novel approaches to trial design in kidney transplantation and is presented as a thesis of published works. Various clinical research methods were used to test the hypothesis that improvements in trial design can lead to the generation of new data, at lower cost and greater efficiency to improve patient outcomes. The first section, presented in Chapters 2 and 3 of the thesis, reports on the trial design considerations and implementation of the Canadian-Australasian RCT of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK). Trial procedures were incorporated into routine care, improving recruitment feasibility and complete outcome ascertainment. A pretrial Markov microsimulation model was also constructed using clinical, costs and utility estimates derived from published literature to estimate the benefits (e.g. survival) and trade-offs (e.g. costs and complications) of the two interventions being tested from a health systems perspective. The pre-trial model defined areas of evidence uncertainty in to help inform data collection for the trial. The second section of the thesis, presented in Chapters 4 and 5, describes a novel method for long-term outcome ascertainment of hard outcomes of kidney transplantation trials. Participant outcomes from five multi-centre RCTs of everolimus-based immunosuppression were linked to the Australian and New Zealand Dialysis and Transplant (ANZDATA) Registry. Meta-analyses using individual participant data were performed to ascertain long term cancer incidence, graft function and patient survival. The third section, chapter 6, presents a systematic review and meta-analysis of controlled trials in the treatment of antibody-mediated rejection (AMR). The risk of bias for all studies and the quality of evidence (for graft survival) were analysed for each treatment regimen, highlighting the deficiencies in existing data, and exemplifying the challenges facing kidney transplantation trials. Results: New data were generated from each of the studies. The CARSK trial was rolled out at 12 Australasian sites, achieving 525 (48%) of the Australasian recruitment target over 2.5 years. Recruitment remains on-going at…

Subjects/Keywords: Kidney transplantation; chronic kidney disease; coronary artery disease; clinical trails

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APA (6^th Edition):

Tracey De-Yi, Y. (2019). Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20927

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tracey De-Yi, Ying. “Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches .” 2019. Thesis, University of Sydney. Accessed April 17, 2021. http://hdl.handle.net/2123/20927.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tracey De-Yi, Ying. “Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches .” 2019. Web. 17 Apr 2021.

Vancouver:

Tracey De-Yi Y. Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches . [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/2123/20927.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tracey De-Yi Y. Clinical Trials in Kidney Transplantation: Design Considerations and Novel Approaches . [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/20927

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

13. Jonge, A.J. de. De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/259972

► Primary hyperaldosteronism is seen in middle-aged and older cats. The zona glomerulosa of the adrenal gland produces the mineralocorticoïd aldosterone. An excess of production of… (more)

▼ Primary hyperaldosteronism is seen in middle-aged and older cats. The zona glomerulosa of the adrenal gland produces the mineralocorticoïd aldosterone. An excess of production of aldosterone in primary hyperaldosteronism originates from tumorous or non-tumorous adrenal tissue. Increase of retention of sodium and excretion of potassium in the kidney can result in systemic arterial hypertension which can cause loss of vision due to retinal detachment and intraocular hemorrhage. Development of hypokalemia may lead to decreased neuromuscular function which shows in episodes of muscle weakness and paresis with typical ventroflexion of the neck. Through thrombosis and fibrosis primary hyperaldosteronism in the cat may progress renal failure. In this study the prevalence of primary hyperaldosteronism was determined amongst a group of eleven cats with chronic kidney disease. Based on plasma creatinine levels of >164 μmol/L cats were selected. Systolic blood pressure was measured with Doppler technique, and eye examination was performed through ophthalmoscopy. Urine and bloodsamples were analyzed. Plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were measured and the PAC to PRA ratio (ARR) was calculated. Primary hyperaldosteronism was diagnosed in one of eleven cats based on ARR (9%). A significant correlation was found between ARR and plasma creatinin. In four cats the systolic bloodpressure was ≥ 185 mmHg, one cat had leasions of the fundus. Hypokalemia was found in three cats, one of them had signs of muscle weakness. To diagnose primary hyperaldosteronism with a higher reliability repeated and complementary measurements are needed. Nevertheless, the disease seems to play an important role in cats with chronic kidney disease. Only a small number of cats were evaluated. More research is required to obtain more data and reliable results concerning the prevalence of primary hyperaldosteronism in cats. Advisors/Committee Members: Kooistra, H.S., Djajadiningrat-Laanen, S.C..

Subjects/Keywords: Diergeneeskunde; primary, hyperaldosteronism, chronic kidney disease, cat

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APA (6^th Edition):

Jonge, A. J. d. (2010). De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/259972

Chicago Manual of Style (16^th Edition):

Jonge, A J de. “De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed April 17, 2021. http://dspace.library.uu.nl:8080/handle/1874/259972.

MLA Handbook (7^th Edition):

Jonge, A J de. “De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden.” 2010. Web. 17 Apr 2021.

Vancouver:

Jonge AJd. De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Apr 17]. Available from: http://dspace.library.uu.nl:8080/handle/1874/259972.

Council of Science Editors:

Jonge AJd. De prevalentie van primair hyperaldosteronisme bij katten met chronisch nierlijden. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/259972

14. Matsuo, Koji. Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる.

Degree: 博士（医学）, 2016, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/41923

►

学位の種類: 博士（医学）. 報告番号: 甲第4124号. 学位記番号: 新大院博（医）甲第691号. 学位授与年月日: 平成28年3月23日

Toxins. 2015, 7(8), 3155-3166.

One of the possible causes of enhanced atherosclerosis in patients with chronic kidney… (more)

Subjects/Keywords: indoxyl sulfate; macrophage; chronic kidney disease; atherosclerosis

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APA (6^th Edition):

Matsuo, K. (2016). Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/41923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matsuo, Koji. “Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる.” 2016. Thesis, Niigata University / 新潟大学. Accessed April 17, 2021. http://hdl.handle.net/10191/41923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matsuo, Koji. “Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる.” 2016. Web. 17 Apr 2021.

Vancouver:

Matsuo K. Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる. [Internet] [Thesis]. Niigata University / 新潟大学; 2016. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/10191/41923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matsuo K. Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. : インドキシル硫酸はマクロファージの炎症反応を促進し、ABCG1を減少させることにより脂質引き抜き能を低下させる. [Thesis]. Niigata University / 新潟大学; 2016. Available from: http://hdl.handle.net/10191/41923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

15. Johnson, Matthew Adam. Influence of dietary fiber on c-reactive protein in dialysis patients.

Degree: MS;, Nutrition;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642

► Chronic kidney disease (CKD) rates continue to rise in the United States. Cardiovascular disease (CVD) accounts for half of all deaths in patients with end… (more)

Subjects/Keywords: Chronic kidney disease; CRP; Dialysis; Fiber

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APA (6^th Edition):

Johnson, M. A. (2010). Influence of dietary fiber on c-reactive protein in dialysis patients. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642

Chicago Manual of Style (16^th Edition):

Johnson, Matthew Adam. “Influence of dietary fiber on c-reactive protein in dialysis patients.” 2010. Masters Thesis, University of Utah. Accessed April 17, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642.

MLA Handbook (7^th Edition):

Johnson, Matthew Adam. “Influence of dietary fiber on c-reactive protein in dialysis patients.” 2010. Web. 17 Apr 2021.

Vancouver:

Johnson MA. Influence of dietary fiber on c-reactive protein in dialysis patients. [Internet] [Masters thesis]. University of Utah; 2010. [cited 2021 Apr 17]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642.

Council of Science Editors:

Johnson MA. Influence of dietary fiber on c-reactive protein in dialysis patients. [Masters Thesis]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642

University of Alberta

16. Harwood, Lori E. Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage.

Degree: PhD, Faculty of Nursing, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/ww72bf12w

► Abstract People with Chronic Kidney Disease (CKD) are asked to make important decisions about if, where and how they will receive dialysis. As the population… (more)

Subjects/Keywords: Critical Realism; Chronic Kidney Disease; Dialysis

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APA (6^th Edition):

Harwood, L. E. (2014). Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ww72bf12w

Chicago Manual of Style (16^th Edition):

Harwood, Lori E. “Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage.” 2014. Doctoral Dissertation, University of Alberta. Accessed April 17, 2021. https://era.library.ualberta.ca/files/ww72bf12w.

MLA Handbook (7^th Edition):

Harwood, Lori E. “Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage.” 2014. Web. 17 Apr 2021.

Vancouver:

Harwood LE. Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Apr 17]. Available from: https://era.library.ualberta.ca/files/ww72bf12w.

Council of Science Editors:

Harwood LE. Conceptualizing Chronic Kidney Disease Dialysis Modality Decision-Making and Home-Dialysis Service Usage. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/ww72bf12w

McMaster University

17. Sekercioglu, Nigar. METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE.

Degree: PhD, 2016, McMaster University

URL: http://hdl.handle.net/11375/20773

► Background and objectives: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic condition defined by an increase in cardiovascular calcifications and bone fragility. The… (more)

▼ Background and objectives: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic condition defined by an increase in cardiovascular calcifications and bone fragility. The condition is diagnosed by abnormal serum concentrations of calcium, phosphorus, parathyroid hormone and vitamin D. These biochemical abnormalities have been linked to abnormal bone metabolism as well as cardiovascular calcifications if left untreated. Phosphate binders are known to cause phosphate reduction through mechanisms involve the gastrointestinal route. Their relative effects remain uncertain. Controversy arises because of concerns related to systematic effects, tolerability, costs and impact on patient important outcomes. The objective of Chapters 2 and 3 was to explore the relative effectiveness of phosphate binders on patient-important outcomes and laboratory outcomes in patients with CKD-MBD using the frequentist and Bayesian approaches, respectively. The purpose of Chapter 4 was to critically appraise clinical practice guidelines addressing CKD-MBD. Methods and results Chapter 2: We performed network meta-analyses for all cause-mortality for individual agents (seven-node analysis) and conventional meta-analysis of calcium vs. non-calcium based phosphate binders (NCBPB) for all-cause mortality, cardiovascular mortality and hospitalization. Our results suggested higher mortality with calcium than either sevelamer in our network meta-analysis or NCBPB in our conventional meta-analysis. Conventional meta-analysis suggested no statistically difference in cardiovascular mortality between calcium and NCBPBs. Chapter 3: We performed Bayesian network meta-analyses to calculate the effect estimates (mean differences) and 95% credible intervals for serum levels of phosphate, calcium and parathyroid hormone. Moderate-quality evidence suggests superior effect of active treatment categories as compared to placebo for reducing serum phosphate. Our NMA results did not find statistically significant difference between active treatment categories in lowering serum phosphate. Chapter 4: We performed a systematic survey to critically appraise clinical practice guidelines addressing CKD-MBD. Most guidelines assessing CKD-MBD suffer from serious shortcomings using the Advancing Guideline Development, Reporting and Evaluation in Health Care instrument II (AGREE) criteria; a minority, however, fulfill the criteria. Limitations with respect to AGREE criteria do not, however, necessarily lead to inappropriate recommendations. Conclusion: Given the likely mortality reduction with sevelamer versus calcium, the results suggest that higher calcium levels associated with calcium based phosphate binders may contribute to the mortality differential. We found that most clinical practice guidelines related to CKD-MBD were not satisfactory with major problems with rigor, update and implementation. Recommendations were consistent and thus unassociated with guideline quality. In other instances, however, this may not be the case, and ensuring… Advisors/Committee Members: Guyatt, Gordan, Health Research Methodology.

Subjects/Keywords: Chronic kidney disease; mineral and bone disorders

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sekercioglu, N. (2016). METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/20773

Chicago Manual of Style (16^th Edition):

Sekercioglu, Nigar. “METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE.” 2016. Doctoral Dissertation, McMaster University. Accessed April 17, 2021. http://hdl.handle.net/11375/20773.

MLA Handbook (7^th Edition):

Sekercioglu, Nigar. “METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE.” 2016. Web. 17 Apr 2021.

Vancouver:

Sekercioglu N. METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE. [Internet] [Doctoral dissertation]. McMaster University; 2016. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/11375/20773.

Council of Science Editors:

Sekercioglu N. METHODOLOGICAL ISSUES IN EVIDENCE SUMMARIES AND GUIDELINES IN MINERAL AND BONE DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE. [Doctoral Dissertation]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/20773

McMaster University

18. Nash, Danielle Marie. UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE.

Degree: PhD, 2019, McMaster University

URL: http://hdl.handle.net/11375/23816

►

Background: International guidelines provide recommendations for early chronic kidney disease care. This thesis was completed to 1) measure the quality of chronic kidney disease care… (more)

▼

Background: International guidelines provide recommendations for early chronic kidney disease care. This thesis was completed to 1) measure the quality of chronic kidney disease care and identify gaps, 2) identify reasons why patients do not receive recommended care, and 3) determine if these guideline-recommended practices are associated with better patient outcomes. Methods: Population-based cohort studies were conducted for studies 1, 3 and 4. Using consensus-based indicators, study 1 quantified the quality of care for patients with early chronic kidney disease. Study 2 was a qualitative descriptive study eliciting primary care physicians’ perceived enablers and barriers to follow-up laboratory testing to confirm chronic kidney disease. Study 3 assessed the association between non-steroidal anti-inflammatory drug (NSAID) use versus non-use and adverse clinical outcomes among older adults. Study 4 assessed whether routine serum creatinine and potassium monitoring (versus no monitoring) following angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) initiation among older adults associated with better outcomes. Results: In study 1, most recommendations were being followed; however, some care gaps were identified. For example, half of the patients with initial abnormal kidney test results did not receive follow-up tests. This finding prompted study 2, where enablers and barriers to this practice were identified. Providers were aware that they should be ordering follow-up tests and had the resources to do so. However, some providers perceived this practice as low priority. In study 3, NSAID use was associated with a higher risk of complications. In study 4, routine ACEi / ARB monitoring did not prevent adverse outcomes. Conclusions: This thesis provides a better understanding of care gaps for patients with early chronic kidney disease in Ontario, and reasons for one of these care gaps. This research also provides evidence to help strengthen guideline recommendations (NSAID avoidance) or refute them (ACEi / ARB monitoring).

Thesis

Doctor of Philosophy (PhD)

Chronic kidney disease is a medical condition where a person’s kidney function is permanently reduced. Family doctors are responsible for the care of patients with early chronic kidney disease. However, many patients may not be receiving the right treatments from their family doctors to keep their kidneys healthy. This research used Ontario healthcare data to identify care gaps for patients with early chronic kidney disease. Interviews were then done with family doctors to identify reasons for one of these care gaps; specifically, why doctors do not always repeat blood and urine tests to confirm if patients have chronic kidney disease. Finally, this research looked at whether providing certain treatments led to better patient outcomes. This information can be used to update current guidelines and to inform strategies which help patients with chronic kidney disease receive the best possible care.

Advisors/Committee Members: Garg, Amit X, Health Research Methodology.

Subjects/Keywords: Chronic kidney disease; Quality of care

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APA (6^th Edition):

Nash, D. M. (2019). UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/23816

Chicago Manual of Style (16^th Edition):

Nash, Danielle Marie. “UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE.” 2019. Doctoral Dissertation, McMaster University. Accessed April 17, 2021. http://hdl.handle.net/11375/23816.

MLA Handbook (7^th Edition):

Nash, Danielle Marie. “UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE.” 2019. Web. 17 Apr 2021.

Vancouver:

Nash DM. UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE. [Internet] [Doctoral dissertation]. McMaster University; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/11375/23816.

Council of Science Editors:

Nash DM. UNDERSTANDING AND IMPROVING THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH CHRONIC KIDNEY DISEASE. [Doctoral Dissertation]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/23816

McMaster University

19. Mehta, Neel. Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease.

Degree: PhD, 2019, McMaster University

URL: http://hdl.handle.net/11375/24942

► Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting more than 10% of the world’s population. CKD is associated with excessive… (more)

▼ Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting more than 10% of the world’s population. CKD is associated with excessive renal fibrosis, which leads to declining kidney function and eventual kidney failure. In CKD, glomerular mesangial cells (MC), resident fibroblasts and tubular epithelial cells undergo phenotypic activation and transition in response to profibrotic and proinflammatory cytokines such as transforming growth factor β1 (TGFβ1). These activated renal cells excessively produce extracellular matrix (ECM) proteins that replace functional renal tissue and lead to renal fibrosis. Caveolae are small omega-shaped invaginations of the plasma membrane that mediate signaling transduction events. Formation of caveolae require the protein caveolin-1 (cav-1). We have previously shown that the ability of MC to produce matrix proteins is dependent on cav-1 expression. Unfortunately, clinically targeting cav-1 within the kidneys, specifically within MC, is technically challenging and as of yet unfeasible. Thus, to better understand how cav-1 deletion is protective, we carried out a microarray screen comparing cav-1 wild-type (WT) and knockout (KO) MC. Here, we discovered significant up-regulation of a TGFβ superfamily inhibitory protein, follistatin (FST). FST specifically targets and neutralizes activin A (ActA) but not TGFβ1. TGFβ1 and ActA both belong to the TGFβ superfamily of cytokines and growth factors. While TGFβ1 itself is a known key mediator of renal fibrosis, therapies aimed at directly inhibiting TGFβ1 in kidney diseases have not been successful due to opposing profibrotic and anti-inflammatory effects. ActA has been shown to act as a strong profibrotic and proinflammatory agent in various organs, including the lungs and liver. We along with others have observed elevated levels of ActA within the kidneys and serum of mice and humans with CKD. Functionally, ActA has been shown to contribute to ECM production in the kidneys. Hence, we hypothesized that ActA inhibition through FST could prove beneficial in CKD. In this thesis, our first study elucidated a novel molecular pathway by which cav-1 regulates expression of the FST in MC. Our results indicate that FST is negatively regulated by cav-1 through a PI3K/PKC zeta/Sp1 transcriptional pathway. Our second study expands on these findings and tests whether exogenous FST administration protects against the progression of CKD in a surgical mouse model of CKD. Here, we discovered that FST acts as a reactive oxygen species (ROS) scavenger and that exogenous administration of FST protects against the development of CKD through the inhibition of renal fibrosis and oxidative stress. Lastly, our third study determined whether microRNAs (miRNAs) are implicated in post-transcriptionally regulating FST through cav-1 and whether these FST-targeting miRNAs can be utilized therapeutically to protect against the development and progression of CKD. Here, we determined that a FST-targeting miRNA, microRNA299a-5p, is significantly… Advisors/Committee Members: Krepinsky, Joan, Medical Sciences.

Subjects/Keywords: Renal Fibrosis; Activin; Follistatin; Chronic Kidney Disease

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APA (6^th Edition):

Mehta, N. (2019). Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/24942

Chicago Manual of Style (16^th Edition):

Mehta, Neel. “Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease.” 2019. Doctoral Dissertation, McMaster University. Accessed April 17, 2021. http://hdl.handle.net/11375/24942.

MLA Handbook (7^th Edition):

Mehta, Neel. “Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease.” 2019. Web. 17 Apr 2021.

Vancouver:

Mehta N. Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease. [Internet] [Doctoral dissertation]. McMaster University; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/11375/24942.

Council of Science Editors:

Mehta N. Molecular Regulation of Follistatin by Caveolin-1 in Glomerular Mesangial Cells and its Therapeutic Potential in Chronic Kidney Disease. [Doctoral Dissertation]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24942

University of Tasmania

20. Gheewala, PA. Early detection and prevention of chronic kidney disease.

Degree: 2018, University of Tasmania

URL: https://eprints.utas.edu.au/28542/1/Gheewala_whole_thesis.pdf

► The global burden of chronic kidney disease (CKD) is significant, and largely fuelled by the epidemics of diabetes and hypertension. CKD is a major risk… (more)

▼ The global burden of chronic kidney disease (CKD) is significant, and largely fuelled by the epidemics of diabetes and hypertension. CKD is a major risk factor for end-stage kidney disease (ESKD), cardiovascular disease (CVD) and premature death. In Australia, data on the prevalence of CKD are limited, and the best available evidence to estimate the CKD burden is drawn from renal replacement therapy (RRT) data. At the end of 2015, the number of patients receiving RRT was 968 per million population and continuing to rise. Evidence suggests that progression and adverse outcomes of CKD can be prevented or delayed by detecting and treating the disease in its initial stages. Unfortunately, CKD is asymptomatic until the kidney function declines by up to 90%; this makes it essential to detect the disease early. Hence, many clinical practice guidelines recommend that individuals with risk factors should be screened for CKD. In light of this evidence, globally, several targeted screening programs have been implemented in various community settings. However, the overall success of these programs is uncertain. Therefore, the aim of Project I was to conduct a systematic review of the literature to determine whether targeted screening programs are effective in identification of early stages of CKD. Despite advancements in the early detection and prevention of CKD, availability of clinical practice guidelines, and development of risk stratification tools, 17% of new patients were referred late to nephrologists for the management of ESKD in Australia. Pharmacists are highly accessible and in a good position to engage people within the community who are not aware of their risks and less likely to access general practice care. Thus, a pharmacist-initiated CKD risk assessment service could help to identify at-risk patients and refer them to general practitioners (GP) for further evaluation and management. Therefore, the aim of Project II was to implement and evaluate a CKD risk assessment service in community pharmacies. Public awareness of CKD is an important determinant of the uptake of screening programs, which may help to address the CKD burden. However, there is a lack of understanding amongst the Australian community about the preventability of major health conditions. Additionally, even amongst sub-group of Australian cohorts with the greatest risk of CKD, the knowledge of CKD risk factors and the recall of kidney function testing were found to be limited. Hence, a final Project III to determine the Australian public knowledge about CKD was conducted. Aim of the thesis The overall aim of this thesis was to identify and implement strategies that could help to improve the early detection and management of CKD in Australia. Methods Project I All observational studies of targeted screening programs implemented in any community-based setting were systematically identified and analysed. The main outcome measures were the percentage of participants with positive screening results and diagnosed with CKD at follow-up, and…

Subjects/Keywords: Chronic kidney disease; screening; community pharmacy; pharmacist

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gheewala, P. (2018). Early detection and prevention of chronic kidney disease. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/28542/1/Gheewala_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gheewala, PA. “Early detection and prevention of chronic kidney disease.” 2018. Thesis, University of Tasmania. Accessed April 17, 2021. https://eprints.utas.edu.au/28542/1/Gheewala_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gheewala, PA. “Early detection and prevention of chronic kidney disease.” 2018. Web. 17 Apr 2021.

Vancouver:

Gheewala P. Early detection and prevention of chronic kidney disease. [Internet] [Thesis]. University of Tasmania; 2018. [cited 2021 Apr 17]. Available from: https://eprints.utas.edu.au/28542/1/Gheewala_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gheewala P. Early detection and prevention of chronic kidney disease. [Thesis]. University of Tasmania; 2018. Available from: https://eprints.utas.edu.au/28542/1/Gheewala_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Miami

21. Singh, Saurav. Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease.

Degree: PhD, Molecular Cell and Developmental Biology (Medicine), 2016, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/1682

► Chronic kidney disease (CKD) is a global health problem that affects 10-15% of the adult population worldwide and significantly increases the risk of death. Patients… (more)

▼ Chronic kidney disease (CKD) is a global health problem that affects 10-15% of the adult population worldwide and significantly increases the risk of death. Patients with CKD develop marked elevations in circulating levels of the phosphaturic hormone, fibroblast growth factor 23 (FGF23), which correlate with the stage of disease, and are associated with higher risk of mortality. Chronic inflammation is a hallmark of CKD. Circulating levels of inflammatory cytokines, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) are significantly elevated in CKD patients and increase with disease progression. This inflammatory burden has been suggested to be a significant contributor to the high mortality rate in CKD. Furthermore, recent clinical studies have demonstrated that in CKD elevated serum levels of FGF23 are independently associated with higher circulating levels of inflammatory cytokines, which can stimulate FGF23 production in osteocytes. These correlative studies suggest a causative role of FGF23 in the development of systemic inflammation in CKD; however, the sources of inflammation and precise molecular mechanisms underlying the pathological interrelationship between deterioration of renal function, elevated FGF23 production and amplification of the inflammatory state are unknown. This thesis project explores the direct effects of FGF23 on the liver. Our data indicate that FGF23 can directly stimulate hepatocytes to produce inflammatory cytokines in the absence of α- klotho, which is the FGF23 co-receptor in the kidney that is not expressed by hepatocytes. By activating FGF receptor isoform 4 (FGFR4), FGF23 stimulates phospholipase Cγ (PLCγ)/calcineurin/nuclear factor of activated T cells (NFAT) signaling in hepatocytes, which increases expression and secretion of inflammatory cytokines, including CRP. We show that the elevation of serum FGF23 levels increases hepatic and circulating levels of CRP in wild-type mice, but not in FGFR4 knockout mice. Furthermore, administration of an isoform-specific FGFR4 blocking antibody reduces hepatic and circulating levels of CRP in the 5/6 nephrectomy rat model of CKD. By demonstrating that FGF23 can directly stimulate hepatic secretion of inflammatory cytokines, our findings suggest a novel mechanism of chronic inflammation in patients with CKD. We postulate that FGFR4 blockade might have therapeutic anti-inflammatory effects in CKD. Advisors/Committee Members: Christian Faul, Pedro Salas, Barry Hudson, Ramiro Verdun.

Subjects/Keywords: Chronic Kidney Disease; FGF23; Inflammation; Liver; FGFR4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Singh, S. (2016). Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1682

Chicago Manual of Style (16^th Edition):

Singh, Saurav. “Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease.” 2016. Doctoral Dissertation, University of Miami. Accessed April 17, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/1682.

MLA Handbook (7^th Edition):

Singh, Saurav. “Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease.” 2016. Web. 17 Apr 2021.

Vancouver:

Singh S. Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease. [Internet] [Doctoral dissertation]. University of Miami; 2016. [cited 2021 Apr 17]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1682.

Council of Science Editors:

Singh S. Fibroblast Growth Factor 23 Directly Targets Hepatocytes to Promote Inflammation in Chronic Kidney Disease. [Doctoral Dissertation]. University of Miami; 2016. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1682

Boston University

22. Alousi, Faisal Fahd. The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease.

Degree: MS, Medical Sciences, 2017, Boston University

URL: http://hdl.handle.net/2144/26653

► The increased risk of atherothrombosis in chronic kidney disease (CKD) has been under extensive examination for decades now. However, a treatment tailored for CKD patients… (more)

Subjects/Keywords: Medicine; Thrombosis; Chronic kidney disease; Indoxyl sulfate

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APA (6^th Edition):

Alousi, F. F. (2017). The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/26653

Chicago Manual of Style (16^th Edition):

Alousi, Faisal Fahd. “The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease.” 2017. Masters Thesis, Boston University. Accessed April 17, 2021. http://hdl.handle.net/2144/26653.

MLA Handbook (7^th Edition):

Alousi, Faisal Fahd. “The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease.” 2017. Web. 17 Apr 2021.

Vancouver:

Alousi FF. The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/2144/26653.

Council of Science Editors:

Alousi FF. The role of indoxyl sulfate in the increased incidence of thrombosis formation in chronic kidney disease. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/26653

University of Manitoba

23. Bourque, Kirsten. Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician.

Degree: Community Health Sciences, 2017, University of Manitoba

URL: http://hdl.handle.net/1993/32529

► Chronic kidney disease (CKD) and its care are not evenly distributed across Canada, and individuals living in rural and remote locations across the country do… (more)

Subjects/Keywords: Chronic kidney Disease; Rural Health Care Delivery

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APA (6^th Edition):

Bourque, K. (2017). Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32529

Chicago Manual of Style (16^th Edition):

Bourque, Kirsten. “Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician.” 2017. Masters Thesis, University of Manitoba. Accessed April 17, 2021. http://hdl.handle.net/1993/32529.

MLA Handbook (7^th Edition):

Bourque, Kirsten. “Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician.” 2017. Web. 17 Apr 2021.

Vancouver:

Bourque K. Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician. [Internet] [Masters thesis]. University of Manitoba; 2017. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1993/32529.

Council of Science Editors:

Bourque K. Managing chronic kidney disease in Northern Manitoba: an innovative model of care using telehealth and a northern based nurse-clinician. [Masters Thesis]. University of Manitoba; 2017. Available from: http://hdl.handle.net/1993/32529

University of Illinois – Chicago

24. Lederer, Swati. Promoting Patient Centered Care in Veterans with Chronic Kidney Disease.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21884

► Background: Patients with chronic kidney disease (CKD) commonly have unmet information needs. Greater patient participation in healthcare discussions can address these needs and improve health… (more)

▼ Background: Patients with chronic kidney disease (CKD) commonly have unmet information needs. Greater patient participation in healthcare discussions can address these needs and improve health outcomes. We developed a patient-centered question prompt sheet (QPS) to engage CKD patients in healthcare conversations. Methods: We conducted a two phase, mixed-methods, cross-sectional study involving semi-structured telephone interviews. Patients with an estimated glomerular filtration rate (eGFR) <60ml/min/1.73m2, on dialysis, or with a kidney transplant were recruited from one Veterans Affairs (VA) nephrology clinic. Phase 1 interviews included open-ended questions assessing patients' CKD-related information needs and generated a preliminary 67-item QPS. Phase 2 interview participants rated the importance of asking each question on a 5-point Likert scale and provided open-ended feedback. All participants rated their willingness to use a CKD-QPS. Input from patient ratings, a multidisciplinary team, and from members of the National Kidney Disease Education Program (NKDEP) Coordinating Panel helped to shorten and refine the QPS. A qualitative thematic approach was used to analyze open-ended responses. Quantitative data were analyzed for means and proportions. Results: Eighty-five patients participated. Most were male (97%), non-Hispanic white (71%), and mean age was 67 years. Patients desired more information about CKD, particularly dialysis/transplant, and the relationship between CKD and comorbid medical conditions. The final QPS included 31-questions divided into 7 CKD subtopics. Most patients (88%) reported being 'completely' or 'very' willing to use a CKD-QPS in future doctor visits. Conclusions: CKD patients have unmet information needs. We developed a QPS to engage CKD patients in healthcare discussions and to facilitate patient-centered care. Future research should assess whether the CKD-QPS addresses patients' information needs, enhances doctor-patient communication, and improves health outcomes. Advisors/Committee Members: Zwanziger, Jack (advisor), Fischer, Michael J (committee member), Gordon, Elisa J (committee member), Gordon, Howard S (committee member), Zwanziger, Jack (chair).

Subjects/Keywords: chronic kidney disease patient-provider communication

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APA (6^th Edition):

Lederer, S. (2017). Promoting Patient Centered Care in Veterans with Chronic Kidney Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lederer, Swati. “Promoting Patient Centered Care in Veterans with Chronic Kidney Disease.” 2017. Thesis, University of Illinois – Chicago. Accessed April 17, 2021. http://hdl.handle.net/10027/21884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lederer, Swati. “Promoting Patient Centered Care in Veterans with Chronic Kidney Disease.” 2017. Web. 17 Apr 2021.

Vancouver:

Lederer S. Promoting Patient Centered Care in Veterans with Chronic Kidney Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/10027/21884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lederer S. Promoting Patient Centered Care in Veterans with Chronic Kidney Disease. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Bristol

25. Rao, Anirudh. Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly.

Degree: PhD, 2019, University of Bristol

URL: http://hdl.handle.net/1983/637def45-b206-4fb7-baec-2af05ab41e1e

► Introduction: Observational studies play a valuable role in nephrology and have informed clinical practice. A significant challenge to observational research is external validity. Threats to… (more)

▼ Introduction: Observational studies play a valuable role in nephrology and have informed clinical practice. A significant challenge to observational research is external validity. Threats to generalisability can occur at the design stage due to selective inclusion criteria, at the recruitment stage due to non-participation of specific groups, and finally at the reporting stage due to poor reporting. Methods: The PhD thesis was a mixed method study of convergent parallel/ triangulation design, embedded into European QUALity Study on treatment in advanced chronic kidney disease (EQUAL). The thesis involved three studies: quantitative, qualitative and systematic review to understand more fully the various factors that could affect a study's generalisability at the design, recruitment and reporting stages respectively. The quantitative arm was a retrospective observational study comparing patients in primary and secondary care meeting the same inclusion criteria as EQUAL. The qualitative arm involved semi-structured interviews with patients who agreed and did not agree to participate in EQUAL. The systematic review assessed the quality of reporting of cohort studies before (1/1/2002-31/12/2007) and after (1/10/2008-31/12/2013) the publication of the STROBE statement. Results: The quantitative arm of the thesis showed that patients in EQUAL were more likely to be younger, male and from an urban setting compared to the primary and secondary care cohort patients. Overall lesser co-morbidity of EQUAL patients meant that they were more likely to be alive at one year or to be admitted to hospital for illnesses. In the qualitative arm of the thesis, patients who agreed to participate in research reported being activated in their healthcare, and this seemed to relate to their decision to take part in research. Altruistic morals had a strong influence on participation in EQUAL study. The issue of caring responsibility and transportation were the main reasons causing inconvenience and negatively influenced participation. The systematic review showed that there had been an improvement in the overall reporting quality of CKD cohort studies particularly in the latter three years of the post-STROBE period. Conclusion: The mixed methods approach of this PhD thesis aided a breadth and depth of understanding of some of the issues affecting generalisability with corroboration of the results from the quantitative and qualitative arms of the study. Sustained efforts of researchers are required to improve the generalisability of research findings at every stage of observational research.

Subjects/Keywords: Generalisability; Cohort studies; validity; Chronic Kidney Disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rao, A. (2019). Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly. (Doctoral Dissertation). University of Bristol. Retrieved from http://hdl.handle.net/1983/637def45-b206-4fb7-baec-2af05ab41e1e

Chicago Manual of Style (16^th Edition):

Rao, Anirudh. “Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly.” 2019. Doctoral Dissertation, University of Bristol. Accessed April 17, 2021. http://hdl.handle.net/1983/637def45-b206-4fb7-baec-2af05ab41e1e.

MLA Handbook (7^th Edition):

Rao, Anirudh. “Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly.” 2019. Web. 17 Apr 2021.

Vancouver:

Rao A. Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly. [Internet] [Doctoral dissertation]. University of Bristol; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1983/637def45-b206-4fb7-baec-2af05ab41e1e.

Council of Science Editors:

Rao A. Understanding generalisability, and issues of recruitment in cohort studies : the example of advanced CKD in the elderly. [Doctoral Dissertation]. University of Bristol; 2019. Available from: http://hdl.handle.net/1983/637def45-b206-4fb7-baec-2af05ab41e1e

University of Gothenburg / Göteborgs Universitet

26. Kashioulis, Pavlos. Cardiac abnormalities in chronic kidney disease.

Degree: 2019, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/60819

► Chronic kidney disease (CKD) is a global health problem associated with increased risk of mortality and development of end-stage renal disease (ESRD). Cardiovascular diseases are… (more)

▼ Chronic kidney disease (CKD) is a global health problem associated with increased risk of mortality and development of end-stage renal disease (ESRD). Cardiovascular diseases are the leading cause of morbidity and mortality even before the development of ESRD. The main purpose of this thesis is to elucidate pathophysiological mechanisms causing cardiac injury in patients with CKD. The specific aims were: 1) To examine the effects of two weeks of high NaCl diet on left ventricular (LV) morphology and serum levels of cardiac troponin-T (cTnT) in rats with adenine-induced chronic renal failure (ACRF). 2) To determine the effects of ACRF on cardiac morphology and function and to examine mechanisms causing cardiac abnormalities. 3) To identify early, sub-clinical, cardiac abnormalities by echocardiography in patients with CKD stages 3 and 4 and to investigate mechanisms that might cause these alterations. Paper 1. Rats with ACRF showed statistically significant increases in arterial pressure (AP), LV weight and fibrosis, and serum cTnT levels compared to controls. Two weeks of high-NaCl intake augmented the increases in AP, LV weight, fibrosis, and serum cTnT concentrations only in ACRF rats and produced LV injury with cardiomyocyte necrosis, scarring, and fibrinoid necrosis of small arteries. Paper 2. Cardiac function was assessed both by echocardiography and by LV catheterization. ACRF rats developed LV hypertrophy and showed signs of LV diastolic dysfunction but systolic function and cardiac output were preserved. Paper 3. In a cohort of patients with CKD stages 3 and 4, and matched controls, we performed comprehensive investigations including echocardiography and assessment of coronary flow velocity reserve (CFVR) in response to adenosine. CKD patients had normal systolic function but showed signs of LV diastolic dysfunction without fulfilling criteria for heart failure with preserved ejection fraction. In addition, CKD patients had significantly reduced CFVR versus controls suggestive of coronary microvascular dysfunction (CMD) In conclusion, ACRF rats developed LV hypertrophy and diastolic dysfunction while systolic performance was preserved. High-NaCl diet in rats with ACRF produced severe LV injury and aggravated increases in serum cTnT levels, presumably by causing hypertension-induced small artery lesions leading to myocardial ischemia. These results support the hypothesis that a high dietary intake of NaCl has deleterious effects on LV integrity in patients with kidney failure. Patients with CKD stages 3 and 4, without a diagnosis of heart disease, showed signs of LV diastolic dysfunction and a relatively large proportion had CMD suggesting that microvascular abnormalities may have a pathogenic role in the development of heart failure in this patient group.

Subjects/Keywords: cardiovascular; chronic kidney disease; diastolic dysfunction

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APA (6^th Edition):

Kashioulis, P. (2019). Cardiac abnormalities in chronic kidney disease. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/60819

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kashioulis, Pavlos. “Cardiac abnormalities in chronic kidney disease.” 2019. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 17, 2021. http://hdl.handle.net/2077/60819.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kashioulis, Pavlos. “Cardiac abnormalities in chronic kidney disease.” 2019. Web. 17 Apr 2021.

Vancouver:

Kashioulis P. Cardiac abnormalities in chronic kidney disease. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/2077/60819.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kashioulis P. Cardiac abnormalities in chronic kidney disease. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. Available from: http://hdl.handle.net/2077/60819

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

27. Robinson-Cohen, Cassianne. Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease.

Degree: PhD, 2013, University of Washington

URL: http://hdl.handle.net/1773/21906

► Background: Physical activity promotes diverse metabolic benefits that may counteract the toxic biochemical environment of chronic kidney disease (CKD). We tested the hypotheses that greater… (more)

▼ Background: Physical activity promotes diverse metabolic benefits that may counteract the toxic biochemical environment of chronic kidney disease (CKD). We tested the hypotheses that greater physical activity levels are associated with lower kidney disease progression, cardiovascular outcomes, and death in a prospective cohort study of stage III-IV CKD patients. Design and setting: We studied 304 participants from the Seattle Kidney Study, a Nephrology clinic-based study of CKD, who had an estimated glomerular filtration rate (eGFR) of 15 to 59 mL/min/1.73 m2. Participants completed questionnaires regarding the frequency and duration of physical activity, and we converted these responses to minutes/week. We used generalized estimating equations and proportional hazards models to quantify associations of physical activity with relative annual decline in eGFR, defined using longitudinal serum cystatin C, and time to clinical outcomes, respectively. Results: Mean eGFR at baseline was 38 mL/min/1.73 m2, mean age was 62 years and mean relative annual change in eGFR was -7%. After adjustment for potential confounders, greater physical activity levels were associated with statistically slower rates of kidney function decline. Each one-category increase in physical activity group was associated with a 1.9% per year slower decline in kidney function (p=0.031). During a median 3.3 years of follow-up, 54 participants died, 48 participants were hospitalized for heart failure and 28 participants developed a component of the composite cardiovascular outcome (incidence rates: 60, 52 and 13 per 1000 person-years, respectively). Our investigation found no association between either the presence or the duration of physical activity with all-cause mortality. On the other hand, we found associations of any physical activity with hospitalized heart failure and with a composite cardiovascular outcome after adjustment for established cardiovascular risk factors. Conclusions: Even moderate levels of physical activity may be sufficient to confer health benefits among CKD patients. Physical activity is emerging as one of few modifiable risk factors for major adverse health outcomes in this high-risk patient population. Advisors/Committee Members: Littman, Alyson (advisor).

Subjects/Keywords: chronic kidney disease; physical activity; Epidemiology; Epidemiology

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APA (6^th Edition):

Robinson-Cohen, C. (2013). Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/21906

Chicago Manual of Style (16^th Edition):

Robinson-Cohen, Cassianne. “Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease.” 2013. Doctoral Dissertation, University of Washington. Accessed April 17, 2021. http://hdl.handle.net/1773/21906.

MLA Handbook (7^th Edition):

Robinson-Cohen, Cassianne. “Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease.” 2013. Web. 17 Apr 2021.

Vancouver:

Robinson-Cohen C. Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease. [Internet] [Doctoral dissertation]. University of Washington; 2013. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1773/21906.

Council of Science Editors:

Robinson-Cohen C. Physical Activity and Clinical Outcomes in the Setting of Chronic Kidney Disease. [Doctoral Dissertation]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21906

28. Alderson, Helen. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.

Degree: PhD, 2017, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-chronic-kidney-disease-related-biomarkers-in-association-with-clinical-characteristics-and-outcomes-in-a-large-prospective-ckd-cohort(de946dd2-b3b6-4466-a8f4-9d5f212d81e2).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703023

► Chronic Kidney Disease (CKD) is common and is associated with increased risk of progression to end stage renal disease, cardiovascular disease and death. CKD is… (more)

▼ Chronic Kidney Disease (CKD) is common and is associated with increased risk of progression to end stage renal disease, cardiovascular disease and death. CKD is a heterogeneous condition and accurately predicting an individual’s risk for adverse outcomes remains a challenge. Over the past decade there has been a focus on the identification of novel biomarkers that may help improve risk stratification and the prediction of clinical endpoints in this population. The overall aim of this research project was to investigate a series of novel biomarkers in patients from the Chronic Renal Insufficiency Standards Implementation Study (CRISIS), a prospective observational study of outcome in all cause non-dialysis dependent CKD 3-5. The biomarkers selected for this project were Anti-Apolipoprotein A-1 (Anti-apoA-1 IgG), fetuin-A, fibroblast growth factor-23 (FGF23), high sensitivity cardiac troponin T (HS-cTnT), kidney injury molecule-1 (KIM-1), N-terminal pro-brain natriuretic peptide (NT-proBNP), neutrophil gelatinase associated lipocalin (NGAL) and osteoprotegerin (OPG). These biomarkers were chosen to address the three clinical endpoints of progression, cardiovascular disease and death with biomarkers considered both individually and as groups of related markers. The first aim of this project was to examine associations between the novel biomarkers and the clinical characteristics of the CRISIS population. The second aim was to investigate the associations between novel biomarkers and the study endpoints. In the case of FGF23 longitudinal measurements were analysed and in all other cases associations between baseline levels of the markers and clinical outcomes were considered. The third aim was to consider whether the biomarkers investigated in this project actually improve parameters of risk stratification and model discrimination, thereby demonstrating a potential to improve the prediction of outcome events in the CKD population. Many of the biomarkers were independently associated with one or all of the clinical outcomes considered. Despite these associations, it was more difficult to demonstrate clear improvement in risk classification or the prediction of clinical endpoints. Baseline models of standard biochemical and clinical parameters performed very well so even biomarkers that were strongly associated with clinical outcomes resulted in only small incremental improvements in the prediction of outcome events. It is now important to focus on defining how biomarkers may fit into clinical decision pathways.

Subjects/Keywords: 616.6; Biomarkers; Chronic Kidney Disease; Outcomes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alderson, H. (2017). Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-chronic-kidney-disease-related-biomarkers-in-association-with-clinical-characteristics-and-outcomes-in-a-large-prospective-ckd-cohort(de946dd2-b3b6-4466-a8f4-9d5f212d81e2).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703023

Chicago Manual of Style (16^th Edition):

Alderson, Helen. “Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.” 2017. Doctoral Dissertation, University of Manchester. Accessed April 17, 2021. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-chronic-kidney-disease-related-biomarkers-in-association-with-clinical-characteristics-and-outcomes-in-a-large-prospective-ckd-cohort(de946dd2-b3b6-4466-a8f4-9d5f212d81e2).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703023.

MLA Handbook (7^th Edition):

Alderson, Helen. “Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort.” 2017. Web. 17 Apr 2021.

Vancouver:

Alderson H. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Apr 17]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-chronic-kidney-disease-related-biomarkers-in-association-with-clinical-characteristics-and-outcomes-in-a-large-prospective-ckd-cohort(de946dd2-b3b6-4466-a8f4-9d5f212d81e2).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703023.

Council of Science Editors:

Alderson H. Investigation of chronic kidney disease related biomarkers in association with clinical characteristics and outcomes in a large prospective CKD cohort. [Doctoral Dissertation]. University of Manchester; 2017. Available from: https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-chronic-kidney-disease-related-biomarkers-in-association-with-clinical-characteristics-and-outcomes-in-a-large-prospective-ckd-cohort(de946dd2-b3b6-4466-a8f4-9d5f212d81e2).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703023

University of Georgia

29. Dickerson, Vanna Marie. Surgical models of renal interstitial fibrosis in cats.

Degree: 2017, University of Georgia

URL: http://hdl.handle.net/10724/36700

► Surgical renal ischemia (RI) has been extensively studied in other species for its utility in modeling kidney disease. The purpose of this work was to… (more)

Subjects/Keywords: Feline; Renal; Ischemia; Fibrosis; Chronic Kidney Disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dickerson, V. M. (2017). Surgical models of renal interstitial fibrosis in cats. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dickerson, Vanna Marie. “Surgical models of renal interstitial fibrosis in cats.” 2017. Thesis, University of Georgia. Accessed April 17, 2021. http://hdl.handle.net/10724/36700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dickerson, Vanna Marie. “Surgical models of renal interstitial fibrosis in cats.” 2017. Web. 17 Apr 2021.

Vancouver:

Dickerson VM. Surgical models of renal interstitial fibrosis in cats. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/10724/36700.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dickerson VM. Surgical models of renal interstitial fibrosis in cats. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36700

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

30. Howarth, Amelia Rose. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.

Degree: PhD, 2020, University of Edinburgh

URL: http://hdl.handle.net/1842/36788

► Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late… (more)

▼ Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late stages of disease. As rates of CKD rise, it is increasingly evident that novel drug targets are required for intervention before these late stages are reached. The purinergic receptor sub-type 7 (P2X7) may represent such a drug target. P2X7, an ATP-gated ion channel, is part of the purinergic signalling pathway and antagonists are safe and well-tolerated in clinical trials as a treatment for inflammatory disease. These trials did not show therapeutic benefit, but recent findings suggest that vascular, rather than immune, functions of P2X7 may be important for renal disease. This project aimed to investigate the expression and role of P2X7 in the renal vasculature in both normal and hypertensive mice. A mouse model of multi-hit renal vascular injury was established and characterised through the administration of angiotensin II (ANGII), deoxycorticosterone (DOCA) and a high salt diet (ANGII DOCA salt model). ANGII DOCA salt mice exhibited mild hypertension, moderate albuminuria, vascular dysfunction, perivascular fibrosis, and a marked increase in renal injury markers in both whole kidney and urine, compared to sham-operated (Sham) littermates. A systematic immunofluorescence study localised P2X7 to the endothelium of renal vessels and glomerular capillaries in both Sham and ANGII DOCA salt mice, as well as localising to areas of injury in ANGII DOCA salt mouse kidneys. The P2X7 antagonist A438079 was able to inhibit ATP-stimulated release of IL-1B in LPS-primed mouse macrophages and was therefore used to assess vascular function in isolated aorta by wire myography. These studies found that activation of P2X7 via agonist BzATP led to vasoconstriction in both mouse groups, an effect that was amplified upon P2X7 inhibitions. Following these findings, it is possible that this is due to a shift in the expression of different P2X7 isoforms with potentially opposing vasoactivity in ANGII DOCA salt mice, compared to Sham mice. This is supported by the observation of differential expression of P2X7 according to the tissue used, the method of detection used, and the disease model investigated. This thesis highlights the importance of considering splice variation under normo- and pathophysiological conditions, both their expressional and functional differences.

Subjects/Keywords: chronic kidney disease; CKD; P2X7; P2X7 isoforms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Howarth, A. R. (2020). The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/36788

Chicago Manual of Style (16^th Edition):

Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed April 17, 2021. http://hdl.handle.net/1842/36788.

MLA Handbook (7^th Edition):

Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Web. 17 Apr 2021.

Vancouver:

Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1842/36788.

Council of Science Editors:

Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: http://hdl.handle.net/1842/36788

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