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1. Burstein, Gayle Diane. An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1).

Degree: PhD, Biochemistry, 2014, University of Texas – Austin

Nitric oxide synthases (NOS) are responsible for the production of nitric oxide (NO), an essential cell-signaling molecule, in mammals. There are three isoforms of NOS with widely different tissue distribution. The overproduction of NO is marked in many human disease states and cancers, however due to the similarities of the enzyme isoforms, targeting NOS for inhibition has proven challenging. Endogenously, the methylated arginines, N[superscript ω]-monomethyl-L-arginine (NMMA) and asymmetric N[superscript ω], N[superscript ω]-dimethyl-L-arginine (ADMA), inhibit NOS. N[superscript ω], N[superscript ω]-Dimethylarginine dimethylaminohydrolase (DDAH1) metabolizes these methylated arginines and thus relieves NOS inhibition. The role of DDAH1 in the regulation of diseases such as cancer and septic shock is still being elucidated. It is thought that targeting DDAH1 for inhibition rather than NOS may circumvent many of the current problems with the treatment of NO overproduction such as isoform selectivity. My PhD studies focus on the synthesis of a series of irreversible inhibitors of DDAH1, an extensive study of their in vitro mode of inhibition, a comparison of analytical fitting methods, and the viability and efficacy of the inactivators in a human cell line. I also studied a potential endogenous inactivator of DDAH1, nitroxyl (HNO), a one-electron reduction product of NO. Advisors/Committee Members: Fast, Walter L. (advisor), Whitman, Christian (committee member), Zhang, Yan (committee member), Iverson, Brent (committee member), Hoffman , David (committee member).

Subjects/Keywords: Enzymology; Dimethylarginine; Nitric oxide; Covalent inhibition; Drug design; DDAH1; Nitroxyl; ADMA; Chloroacetamidine

…that 2- chloroacetamidine irreversibly inactivates PaDDAH (78). Using this small… …superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase. Biochemistry… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Burstein, G. D. (2014). An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1). (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/31281

Chicago Manual of Style (16th Edition):

Burstein, Gayle Diane. “An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1).” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed October 16, 2019. http://hdl.handle.net/2152/31281.

MLA Handbook (7th Edition):

Burstein, Gayle Diane. “An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1).” 2014. Web. 16 Oct 2019.

Vancouver:

Burstein GD. An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1). [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2019 Oct 16]. Available from: http://hdl.handle.net/2152/31281.

Council of Science Editors:

Burstein GD. An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1). [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/31281

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