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You searched for subject:(Chitosan AND thiolated chitosan). Showing records 1 – 2 of 2 total matches.

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1. Narayanan, Deepa. Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -.

Degree: Engineering, 2014, Amrita Vishwa Vidyapeetham (University)

None

References p.103-130, appendix p. 131-132

Advisors/Committee Members: Chennazhi, Krishna Prasad.

Subjects/Keywords: Chitosan; Nanoparticles; Pegylated; Thiolated

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Narayanan, D. (2014). Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/36934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Narayanan, Deepa. “Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -.” 2014. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed July 16, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/36934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Narayanan, Deepa. “Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -.” 2014. Web. 16 Jul 2019.

Vancouver:

Narayanan D. Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2014. [cited 2019 Jul 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/36934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Narayanan D. Pegylated and thiolated chitosan nanoparticles for oral delivery of pth 1 34; -. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/36934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Universitat Ramon Llull

2. Oh, Sejin. Development of mucus permeating nanoparticles-based drug delivery systems.

Degree: 2016, Universitat Ramon Llull

Mucus penetrating nanoparticle-based delivery systems of macromolecular drugs are currently receiving increasing attention in both academic and industrial research. Synthetic delivery systems provide highly suitable and tunable platform for the delivery of the macromolecules. However, a highly viscoelastic and adhesive mucus layer generally traps and rapidly removes most foreign substance from the mucosal surfaces, thereby limiting effectiveness of these nanocarriers. This Thesis is addressed to the development of engineering DNA delivery systems capable of high stability and transfection efficiency with low toxicity, and quickly crossing the mucus layer. Moreover, this Thesis is focused on design and development of methods and techniques in vitro in order to select more efficient delivery systems. A simple and efficient method, based on the use of the quartz crystal microbalance with dissipation (QCM-D) technique, is developed and evaluated the interaction of the polymers and nanoparticles with the mucin layer, resulting in the development of nanoparticle-based delivery systems to mucosal tissue. This highly sensitive technique also offers to evaluate the two opposing properties, needed for the design of efficient mucous permeation systems: mucoadhesion vs mucus penetration. Poly(β-amino ester)s (PBAEs) are currently considered of great interest as biodegradable polymeric carriers of DNA delivery, but they present limited stability in physiological conditions and the inability to penetrate the mucus layer. In this Thesis, we describe a novel surface-modified formulation of DNA delivery systems consisting of PBAE/DNA complexes and the coating agents, including: i) sugars (sucrose, trehalose or mannitol), ii) unmodified chitosan with a 22 kDa (CS) and a with a 60-120 kDa (CSM), iii) chitosan-thioglycolic acid (CS-TGA), and iv) poly(acrylic acid)-bromelain (PAA-BRO) conjugates. All novel formulations formed with different amounts of the coating agents are evaluated the physicochemical properties. The influence of coating agents on transfection efficiency and cytotoxicity is evaluated in COS-7 cells. Particle diffusion through porcine intestinal mucus (PImucus) is assessed by either rotating silicone tube technique or multiple particle tracking (MPT). The results highlight the superior stability, transfection efficiency and mucus permeability of the novel nanoparticle-based drug delivery systems. The effect of the amount of coating agents is also discussed. Advisors/Committee Members: Universitat Ramon Llull. IQS - Bioenginyeria, [email protected] (authoremail), true (authoremailshow), Borrós i Gómez, Salvador (director), true (authorsendemail).

Subjects/Keywords: Mucosal drug delivery systems; Mucus; Mucin; Mucoadhesion; Mucus-permeating; Poly(beta-amino ester)s; Sugar and its derivatives; Chitosan and thiolated chitosan; Bromelain; QCM-D; Ciències; 547; 57; 62

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Oh, S. (2016). Development of mucus permeating nanoparticles-based drug delivery systems. (Thesis). Universitat Ramon Llull. Retrieved from http://hdl.handle.net/10803/382626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Oh, Sejin. “Development of mucus permeating nanoparticles-based drug delivery systems.” 2016. Thesis, Universitat Ramon Llull. Accessed July 16, 2019. http://hdl.handle.net/10803/382626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Oh, Sejin. “Development of mucus permeating nanoparticles-based drug delivery systems.” 2016. Web. 16 Jul 2019.

Vancouver:

Oh S. Development of mucus permeating nanoparticles-based drug delivery systems. [Internet] [Thesis]. Universitat Ramon Llull; 2016. [cited 2019 Jul 16]. Available from: http://hdl.handle.net/10803/382626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oh S. Development of mucus permeating nanoparticles-based drug delivery systems. [Thesis]. Universitat Ramon Llull; 2016. Available from: http://hdl.handle.net/10803/382626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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